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https://www.readbyqxmd.com/read/29160138/a-case-of-dedifferentiated-chondrosarcoma-arising-in-the-cricoid-cartilage-that-mimicked-an-aneurysmal-bone-cyst
#1
Lixiao Chen, Ziwei Yu, Rui Jiang, Pin Dong, Bin Shen, Yu Li
Dedifferentiated chondrosarcoma of the larynx is a rare and highly malignant tumor. We present the report of a 59-year-old man with dedifferentiated laryngeal chondrosarcoma, which was difficult to diagnose even under microscopic examination. The original diagnosis was an aneurysmal bone cyst, and the final diagnosis was established only after careful consideration of the imaging, surgical, and microscopic findings. In clinical practice, there are many similarities between dedifferentiated chondrosarcoma and aneurysmal bone cysts...
November 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29158933/squamous-cell-carcinoma-of-the-thyroid-as-a-result-of-anaplastic-transformation-from-braf-positive-papillary-thyroid-cancer
#2
Alina Basnet, Aakriti Pandita, Joseph Fullmer, Abirami Sivapiragasam
Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tumor or as a component of an anaplastic or undifferentiated carcinoma. We report a patient with TCV of PTC presenting years later with squamous transformation...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29154825/the-scf-ubiquitin-ligase-slimb-controls-nerfin-1-turnover-in-drosophila
#3
Xiaohui Lin, Feng Wang, Yuanpei Li, Chaojun Zhai, Guiping Wang, Xiaoting Zhang, Yang Gao, Tao Yi, Dan Sun, Shian Wu
The C2H2 type zinc-finger transcription factor Nerfin-1 expresses dominantly in Drosophila nervous system and plays an important role in early axon guidance decisions and preventing neurons dedifferentiation. Recently, increasing reports indicated that INSM1 (homologue to nerfin-1 in mammals) is a useful marker for prognosis of neuroendocrine tumors. The dynamic expression of Nerfin-1 is regulated post-transcriptionally by multiple microRNAs; however, its post-translational regulation is still unclear. Here we showed that the protein turnover of Nerfin-1 is regulated by Slimb, the substrate adaptor of SCF(Slimb) ubiquitin ligase complex...
November 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29153840/association-of-omics-features-with-histopathology-patterns-in-lung-adenocarcinoma
#4
Kun-Hsing Yu, Gerald J Berry, Daniel L Rubin, Christopher Ré, Russ B Altman, Michael Snyder
Adenocarcinoma accounts for more than 40% of lung malignancy, and microscopic pathology evaluation is indispensable for its diagnosis. However, how histopathology findings relate to molecular abnormalities remains largely unknown. Here, we obtained H&E-stained whole-slide histopathology images, pathology reports, RNA sequencing, and proteomics data of 538 lung adenocarcinoma patients from The Cancer Genome Atlas and used these to identify molecular pathways associated with histopathology patterns. We report cell-cycle regulation and nucleotide binding pathways underpinning tumor cell dedifferentiation, and we predicted histology grade using transcriptomics and proteomics signatures (area under curve >0...
November 13, 2017: Cell Systems
https://www.readbyqxmd.com/read/29153098/high-amplification-levels-of-mdm2-and-cdk4-correlate-with-poor-outcome-in-patients-with-dedifferentiated-liposarcoma-a-cytogenomic-microarray-analysis-of-47-cases
#5
Robert W Ricciotti, Aaron J Baraff, George Jour, McKenna Kyriss, Yu Wu, Yuhua Liu, Shao-Chun Li, Benjamin Hoch, Yajuan J Liu
Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. To this end, we studied 49 cases of DDLS in our institutional archives and performed cytogenomic microarray analysis on 47 cases. Gene copy numbers for 12 loci were evaluated and correlated with outcome data retrieved from our institutional electronic medical records...
December 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29152115/hdac-4-regulates-claudin-2-expression-in-egfr-erk1-2-dependent-manner-to-regulate-colonic-epithelial-cell-differentiation
#6
Rizwan Ahmad, Balawant Kumar, Kaichao Pan, Punita Dhawan, Amar B Singh
In normal colon, claudin-2 expression is restricted to the crypt bottom containing the undifferentiated and proliferative colonocytes. Claudin-2 expression is also upregulated in colorectal cancer (CRC) and promotes carcinogenesis. However, cellular mechanism/s regulated by increased claudin-2 expression during the CRC and mechanism/s regulating this increase remain poorly understood. Epigenetic mechanisms help regulate expression of cancer-associated genes and inhibition of Histone Deacetylases (HDACs) induces cell cycle arrest and differentiation...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146074/corrigendum-to-diagnostic-utility-of-idh1-2-mutations-to-distinguish-dedifferentiated-chondrosarcoma-from-undifferentiated-pleomorphic-sarcoma-of-bone-hum-pathol-2017-65-239-46
#7
Shaoxiong Chen, Karen Fritchie, Shi Wei, Naser Ali, Kendra Curless, Tiansheng Shen, Anna T Brini, Farida Latif, Vaiyapuri Sumathi, Gene P Siegal, Liang Cheng
No abstract text is available yet for this article.
November 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/29139652/liposarcoma-of-the-spermatic-cord-%C3%A2-a-rare-pathological-entity
#8
Nikola Radović, Arianna Bizatzki, Rajka Turner
Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Ultrasonography revealed a homogenous isodense mass measuring 4...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29137300/patz1-knockdown-enhances-malignant-phenotype-in-thyroid-epithelial-follicular-cells-and-thyroid-cancer-cells
#9
Asumi Iesato, Teruo Nakamura, Hiroto Izumi, Takeshi Uehara, Ken-Ichi Ito
This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. Immunohistochemistry on clinical specimens indicated nuclear PATZ1 expression in all normal thyroid glands and adenomatous goiter, while nuclear PATZ1 expression decreased along with the dedifferentiation of thyroid cancer. Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134785/maintenance-of-cartilaginous-gene-expression-of-serially-subcultured-chondrocytes-on-poly-2-methoxyethyl-acrylate-analogous-polymers
#10
Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka
Chondrocytes are important for cartilage tissue engineering. However, dedifferentiation during chondrocyte subculture prevents the application of cartilage tissue engineering. Therefore, prevention of this dedifferentiation is required. Here, the possibility of poly(2-methoxyethyl acrylate) (PMEA) and its analogous polymers, poly(tetrahydrofurfuryl acrylate) (PTHFA) and poly(2-(2-methoxyethoxy) ethyl acrylate-co-butyl acrylate) (PMe2A), for chondrocyte subculture without dedifferentiation is examined. Chondrocytes spread on PTHFA and polyethylene terephthalate (PET), whereas their spreading is delayed on PMEA and PMe2A...
November 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29134148/transcriptome-dynamics-along-axolotl-regenerative-development-are-consistent-with-an-extensive-reduction-in-gene-expression-heterogeneity-in-dedifferentiated-cells
#11
Carlos Díaz-Castillo
Although in recent years the study of gene expression variation in the absence of genetic or environmental cues or gene expression heterogeneity has intensified considerably, many basic and applied biological fields still remain unaware of how useful the study of gene expression heterogeneity patterns might be for the characterization of biological systems and/or processes. Largely based on the modulator effect chromatin compaction has for gene expression heterogeneity and the extensive changes in chromatin compaction known to occur for specialized cells that are naturally or artificially induced to revert to less specialized states or dedifferentiate, I recently hypothesized that processes that concur with cell dedifferentiation would show an extensive reduction in gene expression heterogeneity...
2017: PeerJ
https://www.readbyqxmd.com/read/29133142/dedifferentiated-endometrial-carcinomas-with-neuroendocrine-features-a-clinicopathologic-immunohistochemical-and-molecular-genetic-study
#12
Iñigo Espinosa, Antonio De Leo, Emanuela D'Angelo, Juan M Rosa-Rosa, Marina Corominas, Alan Gonzalez, José Palacios, Jaime Prat
Undifferentiated endometrial carcinoma is an aggressive type of uterine cancer which is occasionally associated with a low-grade endometrioid carcinoma component. This combination is referred to as "dedifferentiated endometrioid endometrial carcinoma." Neuroendocrine expression may occur in undifferentiated endometrial carcinoma but its significance in dedifferentiated endometrial carcinomas is unknown. To gain insight into the pathogenesis of these tumors we have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, b-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial carcinomas with strong and diffuse neuroendocrine expression...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29131675/dedifferentiated-chondrosarcoma-in-the-dog-and-cat-a-case-series-and-review-of-the-literature
#13
Arathi Vinayak, Deanna R Worley, Stephen J Withrow, Dustin S Adams, Barbara E Powers
This retrospective case series describes seven dogs and one cat diagnosed with dedifferentiated chondrosarcoma, an uncommon, aggressive variant of chondrosarcoma. The purpose of the study is to describe clinical, imaging, and histopathological findings of this tumor. Medical records and the diagnostic laboratory database at Colorado State University from 2000 to 2015 were reviewed and complete medical records were available for the eight animals in this report. Similar to what has been reported in people, poor long-term survival and high metastatic rate, particularly to the lungs, was observed in our case series...
November 13, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29130836/composite-3d-printed-scaffold-with-structured-electrospun-nanofibers-promotes-chondrocyte-adhesion-and-infiltration
#14
M Rampichová, E Košt'áková Kuželová, E Filová, J Chvojka, J Šafka, M Pelcl, J Daňková, E Prosecká, M Buzgo, M Plencner, D Lukáš, E Amler
Additive manufacturing, also called 3D printing, is an effective method for preparing scaffolds with defined structure and porosity. The disadvantage of the technique is the excessive smoothness of the printed fibers, which does not support cell adhesion. In the present study, a 3D printed scaffold was combined with electrospun classic or structured nanofibers to promote cell adhesion. Structured nanofibers were used to improve the infiltration of cells into the scaffold. Electrospun layers were connected to 3D printed fibers by gluing, thus enabling the fabrication of scaffolds with unlimited thickness...
November 13, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29129882/plasticity-in-glioma-stem-cell-phenotype-and-its-therapeutic-implication
#15
Yasuo Iwadate
The marked heterogeneity in glioblastoma (GBM) may be induced through dynamic differentiation and dedifferentiation process of glioma cells. The hypothesis that environmental stimuli induce these phenotypic changes, including dedifferentiation into the stem cell phenotype which contributes to the high invasiveness and resultant poor outcome in GBM patients, is recently being proven. In the process of cancer invasion and metastasis, the phenotypic change has also been described as epithelial-mesenchymal transition (EMT)...
November 13, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29121865/temporally-distinct-transcriptional-regulation-of-myocyte-dedifferentiation-and-myofiber-growth-during-muscle-regeneration
#16
Ke'ale W Louie, Alfonso Saera-Vila, Phillip E Kish, Justin A Colacino, Alon Kahana
BACKGROUND: Tissue regeneration requires a series of steps, beginning with generation of the necessary cell mass, followed by cell migration into damaged area, and ending with differentiation and integration with surrounding tissues. Temporal regulation of these steps lies at the heart of the regenerative process, yet its basis is not well understood. The ability of zebrafish to dedifferentiate mature "post-mitotic" myocytes into proliferating myoblasts that in turn regenerate lost muscle tissue provides an opportunity to probe the molecular mechanisms of regeneration...
November 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29120605/targeting-heat-shock-protein-70-to-ameliorate-c-jun-expression-and-improve-demyelinating-neuropathy
#17
Xinyue Zhang, Chengyuan Li, Stephen C Fowler, Zheng Zhang, Brian S J Blagg, Rick T Dobrowsky
Increased expression of the c-jun transcription factor occurs in a variety of human neuropathies and is critical in promoting Schwann cell (SC) dedifferentiation and loss of the myelinated phenotype. Using cell culture models, we previously identified KU-32 as a novobiocin-based C-terminal heat shock protein 90 (Hsp90) inhibitor that decreased c-jun expression and the extent of demyelination. Additional chemical optimization has yielded KU-596 as a neuroprotective novologue whose mechanistic efficacy to improve a metabolic neuropathy requires the expression of Hsp70...
November 9, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29117831/age-dependent-schwann-cell-phenotype-regulation-following-peripheral-nerve-injury
#18
Wayne A Chen, T David Luo, Jonathan C Barnwell, Thomas L Smith, Zhongyu Li
BACKGROUND: Schwann cells are integral to the regenerative capacity of the peripheral nervous system, which declines after adolescence. The mechanisms underlying this decline are poorly understood. This study sought to compare the protein expression of Notch, c-Jun, and Krox-20 after nerve crush injury in adolescent and young adult rats. We hypothesized that these Schwann cell myelinating regulatory factors are down-regulated after nerve injury in an age-dependent fashion. METHODS: Adolescent (2 months old) and young adult (12 months old) rats (n = 48) underwent sciatic nerve crush injury...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29112123/down-regulation-of-transglutaminase-2-stimulates-redifferentiation-of-dedifferentiated-chondrocytes-through-enhancing-glucose-metabolism
#19
Kyoung-Won Ko, Bogyu Choi, Sunghyun Park, Yoshie Arai, Won Chul Choi, Joong-Myung Lee, Hojae Bae, In-Bo Han, Soo-Hong Lee
Expansion of chondrocytes for repair of articular cartilage can lead to dedifferentiation, making it difficult to obtain a sufficient quantity of chondrocytes. Although previous studies have suggested that culture in a three-dimensional environment induces redifferentiation of dedifferentiated chondrocytes, its underlying mechanisms are still poorly understood in terms of metabolism compared with a two-dimensional environment. In this study, we demonstrate that attenuation of transglutaminase 2 (TG2), a multifunctional enzyme, stimulates redifferentiation of dedifferentiated chondrocytes...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29111382/innovative-approach-to-safely-induce-controlled-lipolysis-by-superparamagnetic-iron-oxide-nanoparticles-mediated-hyperthermic-treatment
#20
Maria Rosaria Marinozzi, Laura Pandolfi, Manuela Malatesta, Miriam Colombo, Veronica Collico, Patricia Marie-Jeanne Lievens, Stefano Tambalo, Chiara Lasconi, Federica Vurro, Federico Boschi, Silvia Mannucci, Andrea Sbarbati, Davide Prosperi, Laura Calderan
During last years, evidence has been provided on the involvement of overweight and obesity in the pathogenesis and aggravation of several life-threatening diseases. Here, we demonstrate that, under appropriate administration conditions, polyhedral iron oxide nanoparticles are efficiently and safely taken up by 3T3 cell line-derived adipocytes (3T3 adipocytes) in vitro. Since these nanoparticles proved to effectively produce heat when subjected to alternating magnetic field, 3T3 adipocytes were submitted to superparamagnetic iron oxide nanoparticles-mediated hyperthermia treatment (SMHT), with the aim of modulating their lipid content...
October 27, 2017: International Journal of Biochemistry & Cell Biology
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