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ascher's syndrome

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https://www.readbyqxmd.com/read/26631379/lst4-the-yeast-fnip1-2-orthologue-is-a-denn-family-protein
#1
Angela Pacitto, David B Ascher, Louise H Wong, Beata K Blaszczyk, Ravi K Nookala, Nianshu Zhang, Svetlana Dokudovskaya, Tim P Levine, Tom L Blundell
The folliculin/Fnip complex has been demonstrated to play a crucial role in the mechanisms underlying Birt-Hogg-Dubé (BHD) syndrome, a rare inherited cancer syndrome. Lst4 has been previously proposed to be the Fnip1/2 orthologue in yeast and therefore a member of the DENN family. In order to confirm this, we solved the crystal structure of the N-terminal region of Lst4 from Kluyveromyces lactis and show it contains a longin domain, the first domain of the full DENN module. Furthermore, we demonstrate that Lst4 through its DENN domain interacts with Lst7, the yeast folliculin orthologue...
December 2015: Open Biology
https://www.readbyqxmd.com/read/26515861/blepharochalasis-with-double-lip-a-case-of-ascher-syndrome
#2
Vishal Gupta, Sujay Khandpur
No abstract text is available yet for this article.
November 2015: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26087089/blepharochalasis-with-double-lip-a-case-of-ascher-syndrome
#3
Vishal Gupta, Sujay Khandpur
No abstract text is available yet for this article.
June 18, 2015: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26032011/the-sticky-platelet-syndrome-during-carotid-endarterectomy
#4
Ahmad A Alsheekh, Alessandra Puggioni, Anil P Hingorani, Natalie Marks, Enrico Ascher
The sticky platelet syndrome is a congenital disorder, characterized by abnormal platelet aggregation in response to epinephrine and/or adenosine phosphate. We present a case of intraoperative carotid artery thrombosis, after patch angioplasty. The successful repair was only feasible on administration of antiplatelet therapy. Presence of sticky platelet syndrome should be considered during vascular operative interventions, and load of antiplatelet agents should be given in patients with unexplained repeated thrombosis of arterial repair, as we described and reported this case...
August 2015: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/26000088/ascher-syndrome-report-of-a-case-with-early-manifestations
#5
Santiago Molina, Pablo Medard, Marcelo Galdeano
Ascher syndrome is a disease of unknown etiology first described in 1920 by Ascher, an ophthalmologist from Prague. It presents with recurrent edema of the lip and upper eyelid resulting in double lip and blepharochalasis. In 10% of cases the idiopathic nontoxic thyroid enlargement also occurs. Because of its rarity, it is often undiagnosed. A case of early onset is presented with its respective surgical treatment and outcome.
June 2015: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/25971175/ascher-s-syndrome-a-rare-case-report
#6
Shivcharan Lal Chandravanshi, Vinay Mishra
An 18-year-old Indian girl with upper lip deformity presented with on and off painless swelling of her both upper eyelids for 3 years. Clinical evaluation revealed bilateral blepharochalasis, narrowing of horizontal palpebral fissure, decreased outer intercanthal distance, iris coloboma, cleft soft palate, bifid uvula, sensorineural deafness and double upper lip. Clinical examination of the thyroid, thyroid hormone assay and ultrasonography revealed normal thyroid gland structure and function. Ascher's syndrome was diagnosed...
March 2015: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/25792835/efficacy-safety-and-impact-on-hospitalizations-of-paliperidone-palmitate-in-recent-onset-schizophrenia
#7
Fan Zhang, Tianmei Si, Chiun-Fang Chiou, Anthony Wf Harris, Chang Yoon Kim, Padmashree Jahagirdar, Steve Ascher
OBJECTIVE: To evaluate the efficacy, safety, and impact on hospitalizations of long-acting injectable paliperidone palmitate (PP) treatment, in patients with recent-onset schizophrenia who had not responded satisfactorily to oral antipsychotics. METHODS: In this 18-month, open-label, Phase-IIIb study from Asia-Pacific region, patients (18-50 years) with recent-onset (≤5 years) schizophrenia unsatisfactorily treated with previous oral antipsychotics were initiated on PP 150 mg eq on day 1, 100 mg eq on day 8, followed by flexible once monthly maintenance doses of 50-150 mg eq...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25576821/the-effect-of-maternal-sleep-disordered-breathing-on-the-infant-s-neurodevelopment
#8
Riva Tauman, Luba Zuk, Shimrit Uliel-Sibony, Jessica Ascher-Landsberg, Shlomit Katsav, Mira Farber, Yakov Sivan, Haim Bassan
OBJECTIVE: We sought to examine the effect of maternal sleep-disordered breathing (SDB) on infant general movements (GMs) and neurodevelopment. STUDY DESIGN: Pregnant women with uncomplicated full-term pregnancies and their offspring were prospectively recruited from a community and hospital low-risk obstetric surveillance. All participants completed a sleep questionnaire on second trimester and underwent ambulatory sleep evaluation (WatchPAT; Itamar Medical, Caesarea, Israel)...
May 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24781441/comparison-of-olanzapine-long-acting-injection-and-oral-olanzapine-a-2-year-randomized-open-label-study-in-outpatients-with-schizophrenia
#9
RANDOMIZED CONTROLLED TRIAL
Holland C Detke, Peter J Weiden, Pierre-Michel Llorca, Moutaz Choukour, Susan B Watson, Elizabeth Brunner, Haya Ascher-Svanum
We compared long-term treatment effectiveness of monthly olanzapine long-acting injection (LAI) with that of oral olanzapine. Outpatients with 2 or more episodes of psychotic worsening in the past 24 months with Positive and Negative Syndrome Scale total score of lower than 70 were randomized to 405 mg/4 weeks of olanzapine LAI (n = 264) or 10 mg/d of oral olanzapine (n = 260) for 2 years of open-label treatment. Dosing thereafter was flexible (150-405 mg/4 weeks of LAI vs 5-20 mg/d of oral). Primary outcome was time to all-cause discontinuation...
August 2014: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/24283222/the-longitudinal-interplay-between-negative-and-positive-symptom-trajectories-in-patients-under-antipsychotic-treatment-a-post-hoc-analysis-of-data-from-a-randomized-1-year-pragmatic-trial
#10
RANDOMIZED CONTROLLED TRIAL
Lei Chen, Joseph A Johnston, Bruce J Kinon, Virginia Stauffer, Paul Succop, Tiago R Marques, Haya Ascher-Svanum
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about the longitudinal pattern of negative symptoms and their linkage with the positive symptoms. This study assessed the temporal interplay between these two symptom domains and evaluated whether the improvements in these symptoms were inversely correlated or independent with each other...
2013: BMC Psychiatry
https://www.readbyqxmd.com/read/23996518/olive-oil-attenuates-the-cholesterol-induced-development-of-nonalcoholic-steatohepatitis-despite-increased-insulin-resistance-in-a-rodent-model
#11
R Buettner, M Ascher, E Gäbele, C Hellerbrand, R Kob, T Bertsch, L C Bollheimer
It is indefinite whether nonalcoholic steatohepatitis (NASH) results as by-product from general metabolic perturbations and adipokine dysregulations or whether defined dietary factors also play a pathogenetic role. Here, we examine the effects of a modification of dietary lipids in a NASH inducing diet on metabolic changes as well as hepatic steatosis, inflammation, and fibrosis in rats. Male Wistar rats were fed with variations of the atherogenic diet (AD), which induces pathophysiological changes resembling human NASH...
October 2013: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/23960483/congenital-double-upper-lip-a-case-report-and-review-of-the-literature
#12
John Spencer M Daniels
Congenital double lip is a rare developmental anomaly which usually involves the upper lip more than the lower lip. It may occur in isolation or as a part of Ascher's syndrome. Sometimes upper and lower double lips occur simultaneously. The occurrence of double lip may result in facial deformity especially when the patient attempts to talk, smile or even show the teeth. It may also interfere with speech or mastication. Although surgery may be undertaken to facilitate speech and mastication, the majority of cases are operated for cosmetic reasons...
July 2010: Saudi Dental Journal
https://www.readbyqxmd.com/read/23807848/movement-disorder-profile-and-treatment-outcomes-in-a-one-year-study-of-patients-with-schizophrenia
#13
Lei Chen, Haya Ascher-Svanum, Anthony Lawson, Virginia L Stauffer, Allen Nyhuis, Virginia Haynes, Kory Schuh, Bruce J Kinon
BACKGROUND: This study identified subgroups of patients with schizophrenia who differed on their movement disorder profile and compared their treatment outcomes. METHODS: Data from a randomized, open-label, one-year study of patients with schizophrenia who were treated with antipsychotics in usual clinical care settings were analyzed (n = 640). Five measures of movement disorder were incorporated into a single Movement Disorder Index (MDI). Subgroups that differed in their movement disorder profile over the one-year study period were compared on clinical and functional outcomes...
2013: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/23601002/ex-vivo-split-liver-transplantation-the-true-right-left-split
#14
Parsia A Vagefi, Justin Parekh, Nancy L Ascher, John P Roberts, Chris E Freise
BACKGROUND: Successful left lateral segment (sectionectomy) and right trisegmentectomy (trisectionectomy) split-liver transplantation (SLT) have been achieved. However, there are few reports of the use of true right/left splitting in SLT. METHODS: A single-centre retrospective review of true right/left ex vivo split-liver transplants performed during the period 1993-2010 was conducted. Nine cadaveric liver grafts underwent splitting and the resultant 18 allografts were used in transplants performed at the study centre...
March 2014: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/23447523/left-hepatectomy-versus-right-hepatectomy-for-living-donor-liver-transplantation-shifting-the-risk-from-the-donor-to-the-recipient
#15
REVIEW
Garrett R Roll, Justin R Parekh, William F Parker, Mark Siegler, Elizabeth A Pomfret, Nancy L Ascher, John Paul Roberts
Living donor liver transplantation (LDLT), originally used in children with left lateral segment grafts, has been expanded to adults who require larger grafts to support liver function. Most adult LDLT procedures have been performed with right lobe grafts, and this means a significant risk of morbidity for the donors. To minimize the donor risk for adults, there is renewed interest in smaller left lobe grafts. The smaller graft size increases the recipient risk in the form of small-for-size syndrome (SFSS) and essentially transfers the risk from the donor to the recipient...
May 2013: Liver Transplantation
https://www.readbyqxmd.com/read/23446198/early-perception-of-medication-benefit-predicts-subsequent-antipsychotic-response-in-schizophrenia-the-consumer-has-a-point-revisited
#16
RANDOMIZED CONTROLLED TRIAL
Haya Ascher-Svanum, Peter Weiden, Allen W Nyhuis, Douglas E Faries, Virginia Stauffer, Sara Kollack-Walker, Bruce J Kinon
BACKGROUND: An easy-to-administer tool for predicting response to antipsychotic treatment could improve the acute management of patients with schizophrenia. We assessed whether a patient's perception of medication benefit early in treatment could predict subsequent response or nonresponse to continued use of the same treatment. METHOD: This post hoc analysis used data from a randomized, open-label trial of antipsychotics for treatment of schizophrenia in which attitudes about medication adherence were assessed after two weeks of antipsychotic treatment using the Rating of Medication Influences (ROMI) scale...
July 2014: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/23216976/long-term-healthcare-costs-and-functional-outcomes-associated-with-lack-of-remission-in-schizophrenia-a-post-hoc-analysis-of-a-prospective-observational-study
#17
Virginia S Haynes, Baojin Zhu, Virginia L Stauffer, Bruce J Kinon, Michael D Stensland, Lei Xu, Haya Ascher-Svanum
BACKGROUND: Little is known about the long-term outcomes for patients with schizophrenia who fail to achieve symptomatic remission. This post-hoc analysis of a 3-year study compared the costs of mental health services and functional outcomes between individuals with schizophrenia who met or did not meet cross-sectional symptom remission at study enrollment. METHODS: This post-hoc analysis used data from a large, 3-year prospective, non-interventional observational study of individuals treated for schizophrenia in the United States conducted between July 1997 and September 2003...
2012: BMC Psychiatry
https://www.readbyqxmd.com/read/23172481/management-of-an-unusual-presentation-of-ascher-syndrome
#18
Adson Andrade de Figuerêdo, Victor Diniz de Pochat, Thaís Fagundes Barreto, Rogério Silva Mendes, Nivaldo Alonso, José Valber Meneses
Ascher syndrome is defined by the association between double lip, blepharochalasis, and nontoxic goiter. Because it is a rare disease, it is most often misdiagnosed, despite its implications for quality of life. We report a variation of an incomplete type of Ascher syndrome affecting the upper lip, upper eyelids, and lateral canthi of a young male patient. The surgical management, follow-up, and a brief overview of the syndrome are described. The results presented show an aesthetic and functional improvement of the facial deformities...
November 2012: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/22974273/construct-validity-of-2-measures-to-assess-reasons-for-antipsychotic-discontinuation-and-continuation-from-patients-and-clinicians-perspectives-in-a-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Douglas Faries, Haya Ascher-Svanum, Glenn Phillips, Allen W Nyhuis, Tomoko Sugihara, Virginia Stauffer, Bruce J Kinon
BACKGROUND: Little is known about the specific reasons for antipsychotic discontinuation or continuation from patients' or clinicians' perspectives. This study aimed to assess the construct validity of 2 new measures of the Reasons for Antipsychotic Discontinuation/Continuation (RAD): RAD-I (a structured interview assessing the patient's perspective) and RAD-Q (a questionnaire assessing the clinician's perspective). METHODS: Data were used from a 12-week antipsychotic trial of schizophrenia patients in which the RAD was administered at study entry and at study completion (or discontinuation)...
2012: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/22879738/validation-of-a-patient-interview-for-assessing-reasons-for-antipsychotic-discontinuation-and-continuation
#20
Louis S Matza, Glenn A Phillips, Dennis A Revicki, Haya Ascher-Svanum, Karen G Malley, Andrew C Palsgrove, Douglas E Faries, Virginia Stauffer, Bruce J Kinon, A George Awad, Richard Se Keefe, Dieter Naber
INTRODUCTION: The Reasons for Antipsychotic Discontinuation Interview (RAD-I) was developed to assess patients' perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct effects of the medication. METHODS: Data were collected from patients with schizophrenia or schizoaffective disorder and their treating clinicians...
2012: Patient Preference and Adherence
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