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Multiple sclerosis AND pain

Geeta Shroff
BACKGROUND: The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be limited in assessing various symptoms of MS that are important. Our study aimed at evaluating the efficacy of a new scoring system, reverse nutech functional score (RNFS) as compared to EDSS in assessing patients with MS treated with human embryonic stem cell (hESC) therapy...
December 2016: Clinical and Translational Medicine
Gordon D Ko, Sara L Bober, Sean Mindra, Jason M Moreau
Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependent relationship between neuropathic pain relief and tetrahydrocannabinol - the principal psychoactive component of cannabis...
2016: Journal of Pain Research
Andres M Alvarez-Pinzon, Aizik L Wolf, Heather N Swedberg, Kory A Barkley, Juan Cucalon, Luciana Curia, Jose E Valerio
OBJECTIVE: The purpose of this retrospective study was to compare and evaluate Percutaneous Retrogasserian Balloon Compression (PBC) and Gamma Knife Radiosurgery (GKRS) for the treatment of trigeminal neuralgia (TN) in patients with multiple sclerosis (MS). METHODS: In this single-center, retrospective comparative study, 202 patients with MS and concomitant TN were evaluated. A minimum follow-up of 24 months was required. Patients with a history of microvascular decompression or previous intervention were excluded...
October 15, 2016: World Neurosurgery
Patrick Vermersch, Maria Trojano
BACKGROUND: Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM: The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD. METHODS: This was an observational, prospective, multicentre, non-interventional study. Patients with resistant MSS prescribed add-on THC:CBD oromucosal spray according to approved labelling, were followed for 3 months...
October 13, 2016: European Neurology
Shengli Ma, Xue Rui, Peiyi Qi, Gangqiong Liu, Jing Yang
BACKGROUND: Poor sleep is common in patients with multiple sclerosis (MS). This study assessed the prevalence of poor sleep and investigated the potential impact factors that influence sleep quality of patients with MS. METHODS: A cross-sectional self-report survey of 231 patients with MS and 265 sex- and age-matched controls was conducted. Good sleepers and poor sleepers were separated by their global score on the Pittsburgh Sleep Quality Index (PSQI). Sociodemographic parameters, such as age, gender, and marital status, and clinical-demographic parameters, such as excessive daytime sleepiness (measured by the Epworth Sleepiness Scale), snoring, insomnia, obstructive sleep apnea, drugs, pain, depression, fatigue, and quality of life, were registered...
October 11, 2016: Sleep & Breathing, Schlaf & Atmung
Samuel S Duffy, Chamini J Perera, Preet G S Makker, Justin G Lees, Pascal Carrive, Gila Moalem-Taylor
Pain is a widespread and debilitating symptom of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. Although central neuroinflammation and demyelination have been implicated in MS-related pain, the contribution of peripheral and central mechanisms during different phases of the disease remains unclear. In this study, we used the animal model experimental autoimmune encephalomyelitis (EAE) to examine both stimulus-evoked and spontaneous pain behaviors, and neuroinflammatory changes, over the course of chronic disease...
2016: Frontiers in Immunology
Srinivas Chivukula, Won Kim, Xiaoyi Zhuo, Stephen Tenn, Tania Kaprealian, Antonio DeSalles, Nader Pouratian
BACKGROUND: The mechanisms by which surgery and radiation elicit pain relief in trigeminal neuralgia (TN) secondary to mass lesions vary widely. We aimed to evaluate the outcomes of radiation to the nerve rather than to the lesion in the treatment of secondary TN. METHODS: We retrospectively reviewed all patients who underwent radiation at the University of California, Los Angeles for TN secondary to tumors. The Barrow Neurological Institute (BNI) pain score was used to evaluate pain outcomes...
October 1, 2016: World Neurosurgery
Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years...
October 2016: Experimental and Therapeutic Medicine
Seyde Shahrbanoo Daniali, Hossein Shahnazi, Samira Kazemi, Elnaz Marzbani
INTRODUCTION: Multiple Sclerosis (MS) is one of the most common autoimmune diseases affecting the central nervous system. The prevalence of it is increasing in our country too. The pain from disorders can affect quality of life. Several studies have pointed to the improvement of patients through educational intervention. This study attempted to evaluate the effectiveness of an educational intervention based on raising the awareness and self-efficacy for pain control among patients with multiple sclerosis during 2015 under the coverage of Isfahan MS Society (IMSS)...
July 24, 2016: Materia Socio-medica
Nora E Fritz, Snehashis Roy, Jennifer Keller, Jerry Prince, Peter A Calabresi, Kathleen M Zackowski
BACKGROUND: Multiple sclerosis (MS) is characterized by physical and mental impairments that often result in pain and reduced quality of life. OBJECTIVE: To understand the relationship of pain, quality of life, and cognition to structural measures of brain volume. METHODS: Behavioral measures were assessed in a single session using standardized questionnaires and rating scales. Brain volume measures were assessed with structural magnetic resonance imaging (MRI)...
September 27, 2016: NeuroRehabilitation
K Pateman, N Cockburn, J Campbell, P J Ford
OBJECTIVES: The symptoms of multiple sclerosis (MS) can affect oral care and access to dental services, but there is limited literature describing the oral health and perceived oral healthcare needs of people with MS. This study aimed to explore the oral health experiences, oral health behaviours and barriers to accessing dental care perceived by people living with MS in Australia. METHODS: Six focus groups were held across two metropolitan areas (Brisbane, Queensland and Melbourne, Victoria) and one regional area (Toowoomba, Queensland)...
September 28, 2016: Community Dentistry and Oral Epidemiology
Jeff Boissoneault, Janelle Letzen, Song Lai, Michael E Robinson, Roland Staud
Studies using arterial spin labelling (ASL) have shown that individuals with chronic fatigue syndrome (CFS) have decreased regional cerebral blood flow, which may be associated with changes in functional neural networks. Indeed, recent studies indicate disruptions in functional connectivity (FC) at rest in chronically fatigued patients including perturbations in static FC (sFC), that is average FC at rest between several brain regions subserving neurocognitive, motor and affect-related networks. Whereas sFC often provides information of functional network reorganization in chronic illnesses, investigations of temporal changes in functional connectivity between multiple brain areas may shed light on the dynamic characteristics of brain network activation associated with such maladies...
September 28, 2016: Clinical Physiology and Functional Imaging
Béatrice Médée, Jean-Baptiste Bouée, Olivier Remy-Neris
OBJECTIVE: Maintaining physical activity for patient with neurological disorders is recommended for patient with multiple sclerosis (MS). The main objective was to assess physical activity and rehabilitation programs in patients with multiple sclerosis and compared it to recently published recommendations. The secondary objective was to evaluate the patient self-perception of these interventions on pain, fatigue, strength and global satisfaction. MATERIALS/PATIENTS AND METHODS: A prospective multicenter study conducted in the four counties of Brittany for patients with MS attending a consultation with a neurologist in the MS network "NeuroSEP Bretagne"...
September 2016: Annals of Physical and Rehabilitation Medicine
Philippe Gallien, Benoit Nicolas, Aurelie Durufle, Claire Le-Meur, Emilie Leblong, Lucie Chochina, Sandrine Robineau, Sabine Petrilli, Jephte Houedakor
OBJECTIVE: Transit disorders are frequent in multiple sclerosis with an impact on the health related quality of life. However, just a few studies have been published on this subject. Moreover, these studies often concern patients with high EDSS. To get a more accurate view, we conducted an epidemiological study including all patients seen in PRM consultation over a given period. MATERIALS/PATIENTS AND METHODS: All MS patients having been seen in PRM consultation over a 4-month period were questioned about the existence of constipation, its consequences and its management...
September 2016: Annals of Physical and Rehabilitation Medicine
Charles Joussain, Mélanie Popoff, Véronique Phé, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Brigitte Schurch, Pierre Denys
OBJECTIVE: Intradetrusor injection of onabotulinum toxin A (IDIBA) is the third-line therapy for patients with neurogenic detrusor overactivity (NDO). There is few evidence of long-term efficacy but no study assessed reasons for failure or abandonment of IDIBA and CISC (clean intermittent self-catheterization) combined strategy. We aimed to assess its long-term outcome in NDO management, and analyze failure and discontinuation. MATERIALS/PATIENTS AND METHODS: We retrospectively reviewed medical records of patients admitted in our neurourology department between 2001 and 2013...
September 2016: Annals of Physical and Rehabilitation Medicine
Moses Rodriguez, Bharath Wootla, George Anderson
BACKGROUND: Alterations in gut microbiota, coupled to increased gut permeability are now widely recognized as having a role in the etiology, course and treatment of many medical conditions, including autoimmune and neurodegenerative disorders. METHODS: In this review, the role that such gut changes play over the course of multiple sclerosis (MS) is detailed. RESULTS: Given the wide array of biological factors and processes that have been shown to be altered in MS, including changes in the gut, this allows for a better integration of the diverse array of pathophysiological processes linked to MS...
September 15, 2016: Current Pharmaceutical Design
Patryk J Woytala, Ewa Morgiel, Anna Łuczak, Katarzyna Czesak-Woytala, Piotr Wiland
BACKGROUND: The therapeutic effects of cyclophosphamide (CP) in the treatment of systemic rheumatic diseases are related to its immune suppressive activity. However effective, the application of CP is restricted due to multiple adverse effects. OBJECTIVES: This retrospective study was conducted to determine the frequency of adverse effects attributed to CP toxicity. MATERIAL AND METHODS: The study involved 65 patients (17 male; 48 female) receiving intravenous CP between October 2007 and December 2010...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Carol Cancelliere, James Donovan, Mette Jensen Stochkendahl, Melissa Biscardi, Carlo Ammendolia, Corrie Myburgh, J David Cassidy
BACKGROUND: Work disability is a major personal, financial and public health burden. Predicting future work success is a major focus of research. OBJECTIVES: To identify common prognostic factors for return-to-work across different health and injury conditions and to describe their association with return-to-work outcomes. METHODS: Medline, Embase, PsychINFO, Cinahl, and Cochrane Database of Systematic Reviews and the grey literature were searched from January 1, 2004 to September 1, 2013...
2016: Chiropractic & Manual Therapies
Paul Wicks, Lawrence Rasouliyan, Bo Katic, Beenish Nafees, Emuella Flood, Rahul Sasané
BACKGROUND: Oral disease-modifying therapies offer equivalent or superior efficacy and greater convenience versus injectable options. OBJECTIVES: To compare patient-reported experiences of fingolimod and dimethyl fumarate. METHODS: Adult relapsing-remitting multiple sclerosis patients treated with fingolimod or dimethyl fumarate were recruited from an online patient community and completed an online survey about treatment side effects, discontinuation, and satisfaction...
2016: BMC Research Notes
Sonja Siegel, Monika Milian, Bernadette Kleist, Tsambika Psaras, Maria Tsiogka, Dagmar Führer, Maria Koltowska-Häggström, Jürgen Honegger, Oliver Müller, Ulrich Sure, Christa Menzel, Michael Buchfelder, Ilonka Kreitschmann-Andermahr
PURPOSE: Quality of life (QoL) and psychosocial well-being are substantially impaired in patients with Cushing's disease (CD), not only at the acute illness stage but also after therapy; however, the reason for these impairments remains unclear. METHODS: In this cross-sectional, patient-reported outcome study, we conducted a postal survey on psychosocial impairment and coping strategies in patients after surgical treatment of CD in three large tertiary referral centers...
September 2, 2016: Pituitary
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