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https://www.readbyqxmd.com/read/27903803/the-human-cytomegalovirus-ie1-protein-antagonizes-pml-nuclear-body-mediated-intrinsic-immunity-via-the-inhibition-of-pml-de-novo-sumoylation
#1
Eva-Maria Schilling, Myriam Scherer, Nina Reuter, Johannes Schweininger, Yves A Muller, Thomas Stamminger
: PML nuclear bodies (NBs) are accumulations of cellular proteins embedded in a scaffold-like structure built by SUMO-modified PML/TRIM19. PML and other NB proteins act as cellular restriction factors against human cytomegalovirus (HCMV), however, this intrinsic defense is counteracted by the immediate-early protein 1 (IE1) of HCMV. IE1 directly interacts with the PML coiled-coil domain via its globular core region and disrupts NB foci by inducing a loss of PML SUMOylation. Here, we demonstrate that IE1 acts via abrogating the de novo SUMOylation of PML...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27895727/deficiency-of-sumo-specific-protease-1-induces-arsenic-trioxide-mediated-apoptosis-by-regulating-xbp1-activity-in-human-acute-promyelocytic-leukemia
#2
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin, Xi Mo
Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxide (As2O3) could induce the upregulation of endoplasmic reticulum (ER) stress, resulting in the apoptosis of NB4 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27807322/-influence-of-hmgb1-mapk-m-tor-signaling-pathway-on-cell-autophagy-and-chemotherapy-resistance-in-k562-cells
#3
Liying Liu, Fei Gao, Yanqiong Ye, Zhiheng Chen, Yunpeng Dai, Ping Zhao, Guotao Guan, Mingyi Zhao
To observe the effect of high-mobility group box 1 (HMGB1) on autophagy and chemotherapy resistance in human leukemiacell line (K562) cells, and to explore the underlying mechanisms.
 Methods: The K562 cells were cultured in vitro and divided into 6 groups: a chemotherapeutic group, a chemotherapeutic control group, a HMGB1 preconditioning group, a HMGB1 preconditioning control group, a HMGB1 siRNA group and a siRNA control group. The chemotherapeutic group was further divided into a vincristine (VCR) group, an etoposide (VP-16) group, a cytosine arabinoside (Ara-C) group, a adriamycin (ADM) group and a arsenic trioxide (As2O3) group...
October 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27784354/-effect-of-decitabine-in-combination-with-arsenic-trioxide-on-prolife-ration-and-apoptosis-of-human-acute-myeloid-leukemia-mv4-11-cells
#4
Si-Si Chen, Yan-Ping Zhao, Wen-Zhong Wu, Tie-Liang Ma, Su-Ning Chen
OBJECTIVE: To investigate the effect of decitabine (DAC) alone or in combination with arsenic trioxide (As2O3) on the proliferation and apoptosis of human acute myeloid leukemia (AML) MV4-11 cells, so as to find an effective method for treating AML with MLL rearrangements. METHODS: The inhibitory effect of DAC and As2O3 alone, as well as in a combination of less than 50% inhibitory concentration (IC50) of DAC, and with less than 20% inhibitory concentration (IC20) As2O3 on MV4-11 cell proliferation were detected by CCK-8 methed; and the apoptosis inducing effect was determined by flow cytometry...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27769816/arsenic-trioxide-induces-cell-cycle-arrest-and-alters-dna-methylation-patterns-of-cell-cycle-regulatory-genes-in-colorectal-cancer-cells
#5
Haniyeh Eyvani, Farima Moghaddaskho, Majid Kabuli, Ali Zekri, Majid Momeny, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
AIMS: Cell cycle dysregulation is important in tumorigenesis. Transcriptional silencing of cell cycle regulatory genes, due to DNA methylation, is a common epigenetic event in malignancies. As2O3 has been shown to induce cell cycle arrest and also to be a potential hypomethylating agent. Our study aimed to investigate DNA methylation patterns of cell cycle regulatory genes promoters, the effects of Arsenic trioxide (As2O3) on the methylated genes and cell cycle distribution in colorectal cancer (CRC) cell lines...
October 18, 2016: Life Sciences
https://www.readbyqxmd.com/read/27750169/arsenic-and-fluoride-induce-apoptosis-inflammation-and-oxidative-stress-in-cultured-human-umbilical-vein-endothelial-cells
#6
Yanqin Ma, Zhenhua Ma, Shuqin Yin, Xiaoyan Yan, Jundong Wang
Excessive amount of inorganic arsenic (iAs) and fluoride (F) coexist in drinking water in many regions, which is associated with high risk of vascular diseases. However, the underlying mechanisms are not well studied. The present study was to evaluate the effects of iAs and F individual or combined exposure on endothelial activation and apoptosis in vitro. Primary human umbilical vein endothelial cells (HUVECs) were exposed to 5 μM As2O3 and/or 1 mM NaF. Changes in endothelial cell apoptosis, inflammation, oxidative stress and nitric oxide (NO) production were analyzed...
October 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27748945/survivint34a-increases-the-therapeutic-efficacy-of-arsenic-trioxide-in-mouse-hepatocellular-carcinoma-models
#7
Anliang Huang, Dan Yue, Danying Liao, Liuliu Cheng, Jinhu Ma, Yuquan Wei, Aiping Tong, Ping Cheng
Arsenic trioxide (ATO) has demonstrated clinical efficacy in acute promyelocytic leukemia (APL) and in vitro activity in various solid tumors. As2O3 as single agent exhibits poor efficacy for treatment of hepatocellular carcinoma (HCC) in phase II trial, suggesting that new modalities of treatment with enhanced therapeutic effect and alleviated toxicity are needed for application of As2O3 on patients with HCC. Survivin is the strongest inhibitor of apoptosis protein over-expressed in tumors, which has been proposed as an attractive target for new anticancer interventions...
October 11, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27747491/influence-of-waterborne-arsenic-on-nutritive-and-potentially-harmful-elements-in-gilthead-seabream-sparus-aurata
#8
Carmen Pérez-Sirvent, Maria José Martínez-Sánchez, Salvadora Martínez López, Maria Del Carmen Gómez Martínez, Francisco A Guardiola, María Ángeles Esteban
Fish are an important source of nutrients in human nutrition. Although arsenic (As) is considered potentially carcinogenic for human being, very little is known about its toxicity in fish biology. To increase our knowledge of the effect of exposure to waterborne As on fish, gilthead seabream (Sparus aurata) were exposed to 5 μM As2O3 and the bioaccumulation of macronutrients (Ca, K, Mg, Na, P), micronutrients (Fe, Mn, Zn) and Potentially Harmful Elements (As, Cd) was determined using spectrometric techniques...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27736677/differential-modulation-of-cellular-antioxidant-status-in-zebrafish-liver-and-kidney-exposed-to-low-dose-arsenic-trioxide
#9
Shuvasree Sarkar, Sandip Mukherjee, Ansuman Chattopadhyay, Shelley Bhattacharya
Zebrafish were exposed to a nonlethal dose (1/350LC50; 50µg/L) of As2O3 and sampled at 7, 15, 30, 60 and 90 days of treatment. The oxidative stress response was assessed in terms of time-dependent histopathological changes, lipid peroxidation, GSH status, activities of detoxification enzymes and expression of antioxidant genes in liver and kidney. As2O3 treatment enhanced lipid peroxidation except at day 90 in liver and day 30 in kidney. Glutathione depleted significantly in the liver except on day 30; whereas in kidney, it increased initially but thereafter depleted significantly...
October 10, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27713174/protective-effects-of-oxymatrine-against-arsenic-trioxide-induced-liver-injury
#10
Li Li, Qinghai Liu, Long Fan, Wei Xiao, Lei Zhao, Yu Wang, Weiguang Ye, Fei Lan, Bin Jia, Hua Feng, Changman Zhou, Xiuqin Yue, Guogang Xing, Tianlong Wang
Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As2O3)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As2O3-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As2O3 intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As2O3 treatment...
October 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27704487/chemical-composition-of-nanoporous-layer-formed-by-electrochemical-etching-of-p-type-gaas
#11
Youcef A Bioud, Abderraouf Boucherif, Ali Belarouci, Etienne Paradis, Dominique Drouin, Richard Arès
We have performed a detailed characterization study of electrochemically etched p-type GaAs in a hydrofluoric acid-based electrolyte. The samples were investigated and characterized through cathodoluminescence (CL), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). It was found that after electrochemical etching, the porous layer showed a major decrease in the CL intensity and a change in chemical composition and in the crystalline phase. Contrary to previous reports on p-GaAs porosification, which stated that the formed layer is composed of porous GaAs, we report evidence that the porous layer is in fact mainly constituted of porous As2O3...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27697713/neurotoxicity-induced-by-arsenic-in-gallus-gallus-regulation-of-oxidative-stress-and-heat-shock-protein-response
#12
Panpan Zhao, Ying Guo, Wen Zhang, Hongliang Chai, Houjuan Xing, Mingwei Xing
Arsenic, a naturally occurring heavy metal pollutant, is one of the functioning risk factors for neurological toxicity in humans. However, little is known about the effects of arsenic on the nervous system of Gallus Gallus. To investigate whether arsenic induce neurotoxicity and influence the oxidative stress and heat shock proteins (Hsps) response in chickens, seventy-two 1-day-old male Hy-line chickens were treated with different doses of arsenic trioxide (As2O3). The histological changes, antioxidant enzyme activity, and the expressions of Hsps were detected...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27677289/arsenic-trioxide-inhibits-lung-metastasis-of-mouse-colon-cancer-via-reducing-the-infiltration-of-regulatory-t-cells
#13
Lei Wang, Xiang Hu, Yingxin Xu, Zhong Liu
The purpose of this study was to investigate the effects of arsenic trioxide (As2O3) on the infiltration of regulatory T cells (Tregs) in the local lung metastasis of mouse colon cancer in vivo and the regulation of Tregs in cytokine-induced killer cells (CIKs) in vitro. A high Tregs infiltration mouse colon cancer lung metastasis model was established by intravenous injection of CT26 murine colon carcinoma cells. Tumor-bearing mice were randomly divided into three groups: control group, low-dose As2O3 group, and high-dose As2O3 group...
September 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27671604/endothelial-to-mesenchymal-transition-contributes-to-arsenic-trioxide-induced-cardiac-fibrosis
#14
Yong Zhang, Xianxian Wu, Yang Li, Haiying Zhang, Zhange Li, Ying Zhang, Longyin Zhang, Jiaming Ju, Xin Liu, Xiaohui Chen, Peter V Glybochko, Vladimir Nikolenko, Philipp Kopylov, Chaoqian Xu, Baofeng Yang
Emerging evidence has suggested the critical role of endothelial to mesenchymal transition (EndMT) in fibrotic diseases. The present study was designed to examine whether EndMT is involved in arsenic trioxide (As2O3)-induced cardiac fibrosis and to explore the underlying mechanisms. Cardiac dysfunction was observed in rats after exposure to As2O3 for 15 days using echocardiography, and the deposition of collagen was detected by Masson's trichrome staining and electron microscope. EndMT was indicated by the loss of endothelial cell markers (VE-cadherin and CD31) and the acquisition of mesenchymal cell markers (α-SMA and FSP1) determined by RT-PCR at the mRNA level and Western blot and immunofluorescence analysis at the protein level...
September 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27665715/arsenic-trioxide-and-triptolide-synergistically-induce-apoptosis-in-the-skm%C3%A2-1-human-myelodysplastic-syndrome-cell-line
#15
Hai-Ying Hua, Hua-Qiang Gao, Ai-Ning Sun, Jian-Nong Cen, Li-Li Wu
Although certain combination therapies comprising arsenic trioxide (As2O3) with other agents exist for the treatment of several types of human cancer, few As2O3 combination therapies are clinically effective for myelodysplastic syndromes (MDS). Triptolide (TL) may be an effective therapeutic agent for the treatment of MDS. However, to date, there is no combination therapy for MDS with As2O3 and TL. Therefore, the aim of the present study was to investigate this combination therapy on the apoptosis of MDS SKM‑1 cells...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27608960/differential-mechanistic-investigation-of-protective-effects-from-imperatorin-and-sec-o-glucosylhamaudol-against-arsenic-trioxide-induced-cytotoxicity-in-vitro
#16
Liufang Hu, Jianhui Sun, Hongmei Li, Lifang Wang, Yuna Wei, Ying Wang, Yaying Zhu, Hairu Huo, Yuqing Tan
BACKGROUND AND PURPOSE: The clinical use of arsenic trioxide (As2O3) for treating acute promyelocytic leukemia (APL) is limited due to its severe cardiotoxicity. The possible mechanisms of As2O3-induced cardiotoxicity include DNA fragmentation, reactive oxygen species (ROS) generation, cardiac ion channel changes and apoptosis. The present study is designed to investigate the protective effects of imperatorin and sec-O-glucosylhamaudol and to explore their mechanistic involvement in As2O3-induced cytotoxicity...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27561292/activation-of-the-nrf2-signaling-pathway-involving-klf9-plays-a-critical-role-in-allicin-resisting-against-arsenic-trioxide-induced-hepatotoxicity-in-rats
#17
Daqian Yang, Zhanjun Lv, Haili Zhang, Biying Liu, Huijie Jiang, Xiao Tan, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang
Arsenic trioxide (As2O3) is both the most prevalent, naturally occurring inorganic arsenical threatening human health and an efficient therapeutic for acute promyelocytic leukemia. Regretfully, As2O3-treated cancer patients often suffer from hepatotoxicity. While effective antioxidant and anticarcinogenic actions of allicin have previously been demonstrated, studies indicating how allicin affects As2O3-induced hepatotoxicity and arsenic accumulation are lacking. Our study, for the first time, elaborates potential details of the hepatoprotective mechanisms of allicin against As2O3-induced liver injury...
August 25, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27522209/simultaneous-analysis-26-mineral-element-contents-from-highly-consumed-cultured-chicken-overexposed-to-arsenic-trioxide-by-inductively-coupled-plasma-mass-spectrometry
#18
Ying He, Bonan Sun, Siwen Li, Xiao Sun, Ying Guo, Hongjing Zhao, Yu Wang, Guangshun Jiang, Mingwei Xing
This study assessed the impacts of dietary arsenic trioxide (As2O3) on 26 mineral element contents in the liver and kidney of chicken. A total of 100 male Hy-line cocks were randomly divided into 2 groups (50 chickens in each group), including an arsenic-treated group (basic diet supplemented with As2O3 at 30 mg/kg) and a control group (basal diet). The feeding experiment lasted for 90 days and the experimental animals were given free access to feed and water. We determined 26 mineral elements in the liver and kidney by inductively coupled plasma mass spectrometry (ICP-MS)...
August 13, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27498627/runx3-plays-an-important-role-in-as2o3%C3%A2-induced-apoptosis-and-allows-cells-to-overcome-msc%C3%A2-mediated-drug-resistance
#19
Guo-Zheng Pan, Feng-Xian Zhai, Yin Lu, Zhi-Gang Fang, Rui-Fang Fan, Xiang-Fu Liu, Dong-Jun Lin
The interaction between bone marrow stromal cells and leukemia cells is critical for the persistence and progression of leukemia, and this interaction may account for residual disease. However, the link between leukemia cells and their environment is still poorly understood. In our study, runt‑related transcription factor 3 (RUNX3) was identified as a novel target gene affected by As2O3 and involved in mesenchymal stem cell (MSC)‑mediated protection of leukemia cells from As2O3‑induced apoptosis. We observed induction of RUNX3 expression and the translocation of RUNX3 into the nucleus after As2O3 treatment in leukemia cells...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27382405/a-meta-analysis-of-arsenic-trioxide-combined-with-transcatheter-arterial-chemoembolization-for-treatment-of-primary-hepatic-carcinoma
#20
Ling He, Qingyun Xu, Liguo Chen, Ruixue Chen
Primary hepatic carcinoma (PHC) is one of the most common malignant tumours in the world. More and more research has shown that As2O3 combined with TACE has a good curative effect in treating PHC. The objectives of this study were to evaluate the therapeutic efficacy and safety of As2O3 combined with TACE in treating PHC. The CNKI, VIP, Wanfang, PubMed, and Cochrane databases were searched from their inception until December 2015. Randomized controlled trials (RCTs) comparing As2O3 combined with TACE versus TACE alone in treating PHC were identified...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
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