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https://www.readbyqxmd.com/read/28437960/wind-ranging-and-velocimetry-with-low-peak-power-and-long-duration-modulated-laser
#1
Eiichi Yoshikawa, Tomoo Ushio
A novel approach to simultaneous wind ranging and velocimetry using low peak power, long-duration modulated laser pulse transmissions is proposed. Received signals backscattered by aerosol particles are processed by a multi-reference matched-filter (MRMF) which performs matched filter processing between the received signal and several reference signals in parallel and outputs a range-velocity profile of received power. Ranging and velocimetry are performed simultaneously by estimating received power, radial velocity, and velocity dispersion from a velocity profile at an arbitrary range in the range-velocity profile...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437933/optical-wave-parameters-for-spatially-dispersive-and-anisotropic-nanomaterials
#2
Andriy Shevchenko, Markus Nyman, Ville Kivijärvi, Matti Kaivola
Spatial dispersion is an intriguing property of essentially all nanostructured optical media. In particular, it makes optical waves with equal frequencies and polarizations have different wavelengths, if they propagate in different directions. This can offer new approaches to control light radiation and propagation. Spatially dispersive nanomaterials, such as metamaterials, are often treated in terms of wave parameters, such as refractive index and impedance retrieved from reflection and transmission coefficients of the material at each incidence angle...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437905/amplitude-modulation-of-femtosecond-laser-pulses-in-the-megahertz-range-for-frequency-multiplexed-two-photon-imaging
#3
Dmitri Tsyboulski, Natalia Orlova, Peter Saggau
We present a frequency-multiplexed multi-site two-photon imaging method utilizing amplitude modulation of femtosecond laser pulses in the MHz range to tag each excitation beam and the corresponding fluorescence signals with specific frequencies. The frequency tags are generated with an interferometric scheme employing acousto-optic deflectors (AODs) to achieve precise spatial overlap of femtosecond laser pulses with periodically varying phase shift. Creating matching excitation beam patterns in each interferometer arm using multiple AOD driving frequencies, and subsequently overlapping these matching patterns, results in multiple encoded excitation beams with unique beat frequencies available for scanning...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437904/ray-mapping-with-surface-information-for-freeform-illumination-design
#4
Caleb Gannon, Rongguang Liang
A novel approach to incorporate surface information into the ray mapping method is proposed. This method calculates irradiance at the physical optical surface and target plane instead of the usually flat or hemispherical dummy surface, resulting in a mapping relationship which reflects the true geometry of the system. The robustness of the method is demonstrated in an extreme example (60° off axis) where the uniformity is as high as 82%.
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437868/early-mortality-and-overall-survival-of-acute-myeloid-leukemia-based-on-facility-type
#5
Vijaya R Bhatt, Valerie Shostrom, Smith Giri, Krishna Gundabolu, K M Monirul Islam, Frederick R Appelbaum, Lori J Maness
Cancer health disparities may exist based on the facility type. We aimed to determine the association between the academic status of centers and outcomes of patients with acute myeloid leukemia (AML). Using the National Cancer Data Base, we compared one-month mortality and longer-term overall survival (OS) of 60,738 patients with AML, who received first course treatment between 2003-2011 at academic or non-academic centers (community cancer program, comprehensive community cancer program, and others). Multivariate analysis was done using logistic regression for one-month mortality and Cox regression with backward elimination approach for OS...
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437853/inhibition-of-tgf-%C3%AE-signaling-promotes-expansion-of-human-epidermal-keratinocytes-in-feeder-cell-co-culture
#6
Daisuke Suzuki, Filipa Pinto, Makoto Senoo
Cultured epidermal autografts have been used worldwide since 1981 for patients with extensive third-degree burn wounds and limited skin donor sites. Despite significant progress in techniques toward improving clinical outcome of skin grafts, the long in vitro preparation time of cultured autografts has remained a major factor limiting its widespread use. Here, we show that pharmacological inhibition of TGF-β signaling promotes the expansion of human epidermal keratinocytes (HEKs) with high proliferative potential in co-cultures with both murine 3T3-J2 cells and human feeder cells, including dermal fibroblasts and preadipocytes...
April 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28437848/inferring-network-structure-in-non-normal-and-mixed-discrete-continuous-genomic-data
#7
Anindya Bhadra, Arvind Rao, Veerabhadran Baladandayuthapani
Inferring dependence structure through undirected graphs is crucial for uncovering the major modes of multivariate interaction among high-dimensional genomic markers that are potentially associated with cancer. Traditionally, conditional independence has been studied using sparse Gaussian graphical models for continuous data and sparse Ising models for discrete data. However, there are two clear situations when these approaches are inadequate. The first occurs when the data are continuous but display non-normal marginal behavior such as heavy tails or skewness, rendering an assumption of normality inappropriate...
April 24, 2017: Biometrics
https://www.readbyqxmd.com/read/28437804/-prognostic-factors-of-open-abdomen-treatment-in-visceral-surgery
#8
Martin W von Websky, Agnes Jedig, Arnulf Willms, Azin Jafari, Hanno Matthaei, Jörg C Kalff, Steffen Manekeller
Introduction In general surgery, open abdomen treatment (OAT) is used to treat abdominal compartment syndrome (ACS) and sepsis, often after a primary surgical procedure associated with complications. The results achieved in this patient population may depend on factors that are yet unknown. This study evaluates independent patient-related prognostic factors after OAT. Methods 38 clinical parameters and survival data of 165 consecutive general surgery patients after OAT were entered into a prospective database according to a defined algorithm in order to analyse the underlying surgical pathology, predictors of survival and important aspects of OAT-related morbidity...
April 24, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28437745/comparative-study-of-the-effects-of-gadolinium-chloride-and-gadolinium-based-magnetic-resonance-imaging-contrast-agent-on-freshwater-mussel-dreissena-plymorpha
#9
Houda Hanana, Patrice Turcotte, Chantale André, Christian Gagnon, François Gagné
Gadolinium (Gd), a metal of the lanthanide series used in various industrial and medical purposes is released into the aquatic environment. However, there are few aquatic toxicological studies addressing environmental effects of Gd which remains unknown in aquatic animals. Therefore, this study aimed to compare the effects of GdCl3 and a gadolinium-based MRI contrast agent (Omniscan), in zebra mussels after 28 days through a multibiomarker approach. Data revealed that after GdCl3 exposure, the mRNA level of metallothionein (MT) was modulated, those of cytochrome c oxidase (CO1) and superoxide dismutase (SOD) were increased, while gene expressions of catalase (CAT) and glutathione-S-transferase (GST) were downregulated...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437718/nontargeted-metabolomics-approach-for-the-differentiation-of-cultivation-ages-of-mountain-cultivated-ginseng-leaves-using-uhplc-qtof-ms
#10
Xiangwei Chang, Juanjuan Zhang, Dekun Li, Dazheng Zhou, Yuling Zhang, Jincheng Wang, Bing Hu, Aichun Ju, Zhengliang Ye
The adulteration or falsification of the cultivation age of mountain cultivated ginseng (MCG) has been a serious problem in the commercial MCG market. To develop an efficient discrimination tool for the cultivation age and to explore potential age-dependent markers, an optimized ultra high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS)-based metabolomics approach was applied in the global metabolite profiling of 156 MCG leaf (MGL) samples aged from 6 to 18 years...
April 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28437708/primary-secondary-and-tertiary-prevention-of-human-papillomavirus-driven-head-and-neck-cancers
#11
REVIEW
Haïtham Mirghani, Alain C Jung, Carole Fakhry
Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiological change strongly calls for preventive measures. Prophylactic HPV vaccination and screening programmes for early identification and treatment of premalignant lesions are currently being used to reduce the incidence of uterine cervical cancer, which is the paradigm of HPV-driven malignancy...
April 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28437693/an-assessment-of-the-social-cognitive-predictors-of-exclusive-breastfeeding-behavior-using-the-health-action-process-approach
#12
J L Martinez-Brockman, F M Shebl, N Harari, R Pérez-Escamilla
RATIONALE: In the United States rates of exclusive breastfeeding duration remain exceedingly low. Exclusive breastfeeding is a complex learned behavior that is influenced by social cognitive, interpersonal, and structural factors. Interventions are needed that address factors at multiple levels of the social-ecological model. This study was designed to examine the social cognitive predictors of exclusive breastfeeding behavior in a sample of low-income women attending the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) breastfeeding peer counseling program and enrolled in the Lactation Advice Through Texting Can Help (LATCH) study...
April 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28437672/eosinophilic-funiculitis-initially-diagnosed-as-irreducible-inguinal-hernia-a-case-report
#13
Kohei Yamada, Akashi Ikubo, Shota Ikeda, Satoko Koga, Yasuhiro Tsuru, Hideo Kuroki, Naohiko Koya, Ryuichiro Samejima, Masashi Sakai, Masanobu Tabuchi, Seiji Yunotani, Shinichi Kido, Kazushige Nishimura, Hiroyuki Meiri
BACKGROUND: Most groin masses are first suspected to be groin hernias. More than 80% of bulging groin lesions are reportedly diagnosed as hernias by ultrasonography. Establishment of the correct diagnosis of hernia among all differential diagnoses is not easy. We herein describe a very rare case of groin eosinophilic funiculitis that presented as an irreducible groin hernia. CASE PRESENTATION: A 59-year-old man presented to our hospital with suspicion of a right groin hernia...
April 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28437664/upscaling-of-fungal-bacterial-interactions-from-the-lab-to-the-field
#14
REVIEW
Wietse de Boer
Fungal-bacterial interactions (FBI) are an integral component of microbial community networks in terrestrial ecosystems. During the last decade, the attention for FBI has increased tremendously. For a wide variety of FBI, information has become available on the mechanisms and functional responses. Yet, most studies have focused on pairwise interactions under controlled conditions. The question to what extent such studies are relevant to assess the importance of FBI for functioning of natural microbial communities in real ecosystems remains largely unanswered...
April 21, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28437654/enhancement-of-particle-aggregation-in-the-presence-of-organic-matter-during-neutralization-of-acid-drainage-in-a-stream-confluence-and-its-effect-on-arsenic-immobilization
#15
Guillermo Arce, Mauricio Montecinos, Paula Guerra, Cristian Escauriaza, Marina Coquery, Pablo Pastén
Acid drainage (AD) is an important environmental concern that impacts water quality. The formation of reactive Fe and Al oxyhydroxides during the neutralization of AD at river confluences is a natural attenuation process. Although it is known that organic matter (OM) can affect the aggregation of Fe and Al oxyhydroxides and the sorption of As onto their surfaces, the role of OM during the neutralization of AD at river confluences has not been studied. Field and experimental approaches were used to understand this role, using the Azufre River (pH 2) - Caracarani River (pH 8...
March 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437650/indoor-to-outdoor-relationship-of-aerosol-particles-inside-a-naturally-ventilated-apartment-a-comparison-between-single-parameter-analysis-and-indoor-aerosol-model-simulation
#16
Tareq Hussein
The indoor-to-outdoor relationship of aerosol particles is affected by several mechanisms including penetration, ventilation rate, dry deposition rate and sources. Understanding the effect of these factors is essential for a deeper knowledge of the indoor-to-outdoor relationship. In real-life conditions, it is difficult to analyze these factors in a naturally ventilated environment. In this study, a naturally ventilated and an occupied apartment was used to investigate the indoor-to-outdoor relationship of aerosol particles by applying two different techniques; single-parameter analysis and indoor aerosol model simulation...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#17
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28437594/a-mesoamerican-origin-of-cherimoya-annona-cherimola-mill-implications-for-the-conservation-of-plant-genetic-resources
#18
N Larranaga, F J Albertazzi, G Fontecha, M Palmieri, H Rainer, M van Zonneveld, J I Hormaza
Knowledge on the structure and distribution of genetic diversity is a key aspect in order to plan and execute an efficient conservation and utilization of the genetic resources of any crop as well as for determining historical demographic inferences. In this work, a large data set of 1765 accessions of cherimoya (Annona cherimola Mill, Annonaceae), an underutilized fruit tree crop native to the neotropics and used as a food source by pre-Columbian cultures, was collected from 6 different countries across the American continent and amplified with 9 highly informative microsatellite markers...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437560/phylogeography-and-population-structure-analysis-reveals-diversity-by-mutations-in-lasiodiplodia-theobromae-with-distinct-sources-of-selection
#19
P H D Santos, B M Carvalho, K P Aguiar, F A S Aredes, T P S Poltronieri, J M S Vivas, V Mussi Dias, G A Bezerra, D B Pinho, M G Pereira, S F Silveira
Lasiodiplodia theobromae is a plant pathogen with a worldwide distribution, with low host specificity, causing stem cankers, dieback diseases, and fruit rot in several species of plants. In coconut, this pathogen is reported as the etiological agent of "coconut leaf blight" (CLB) disease, causing several losses in fruit production. The CLB is an important disease for this crop in Brazil. In our study, we used a phylogeographic approach through the molecular characterization of the translation elongation factor 1-α (TEF1-α) to elucidate the pathogen distribution in Brazil and other countries, besides, search information about diversity sources of this pathogen in coconut palm tree at Brazilian northern, northeast, and southeast...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437546/root-cause-analysis-and-actions-for-the-prevention-of-medical-errors-quality-improvement-and-resident-education
#20
Ryan Charles, Brandon Hood, Joseph M DeRosier, John W Gosbee, James P Bagian, Ying Li, Michelle S Caird, J Sybil Biermann, Mark E Hake
The quality of care delivered by orthopedic surgeons continues to grow in importance. Multiple orthopedic programs, organizations, and committees have been created to measure the quality of surgical care and reduce the incidence of medical adverse events. Structured root cause analysis and actions (RCA2) has become an area of interest. If performed thoroughly, RCA2 has been shown to reduce surgical errors across many subspecialties. The Accreditation Council for Graduate Medical Education has a new mandate for programs to involve residents in quality improvement processes...
April 24, 2017: Orthopedics
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