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https://www.readbyqxmd.com/read/29352739/determination-of-protein-oligomeric-structure-from-small-angle-x-ray-scattering
#1
REVIEW
David A Korasick, John J Tanner
Small-angle X-ray scattering (SAXS) is useful for determining the oligomeric states and quaternary structures of proteins in solution. The average molecular mass in solution can be calculated directly from a single SAXS curve collected on an arbitrary scale from a sample of unknown protein concentration, without the need for beamline calibration or protein standards. The quaternary structure in solution can be deduced by comparing the experimental SAXS curve to theoretical curves calculated from proposed models of the oligomer...
January 20, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29352717/should-we-use-cell-of-origin-and-dual-protein-expression-in-treating-dlbcl
#2
REVIEW
Peter A Riedell, Sonali M Smith
Treatment outcomes in diffuse large B-cell lymphoma (DLBCL) following standard R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy is highly variable and dependent on a number of clinical, biologic, and genetic features. The identification of molecular heterogeneity via gene expression profiling dichotomizes patients based on the cell of origin (COO) model into germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subsets, with ABC-DLBCL having a worse outcome...
December 24, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29352711/gold-cleaning-methods-for-preparation-of-cell-culture-surfaces-for-self-assembled-monolayers-of-zwitterionic-oligopeptides
#3
Junko Enomoto, Tatsuto Kageyama, Dina Myasnikova, Kisaki Onishi, Yuka Kobayashi, Yoko Taruno, Takahiro Kanai, Junji Fukuda
Self-assembled monolayers (SAMs) have been used to elucidate interactions between cells and material surface chemistry. Gold surfaces modified with oligopeptide SAMs exhibit several unique characteristics, such as cell-repulsive surfaces, micropatterns of cell adhesion and non-adhesion regions for control over cell microenvironments, and dynamic release of cells upon external stimuli under culture conditions. However, basic procedures for the preparation of oligopeptide SAMs, including appropriate cleaning methods of the gold surface before modification, have not been fully established...
January 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29352668/the-effect-of-single-and-repeated-prefrontal-intermittent-theta-burst-stimulation-on-cortical-reactivity-and-working-memory
#4
Sung Wook Chung, Nigel C Rogasch, Kate E Hoy, Paul B Fitzgerald
BACKGROUND: With an increasing interest in the use of theta burst stimulation (TBS) as a cognitive enhancer and a potential therapeutic tool for psychiatric disorders, there is a need to identify optimal parameters of TBS in the prefrontal cortex. OBJECTIVE/HYPOTHESIS: This study examined the effect of two blocks of prefrontal intermittent TBS (iTBS) on cortical reactivity and working memory performance, compared to one block of iTBS and sham stimulation. We hypothesized that greater cortical effects would be obtained with two blocks of iTBS...
January 8, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29352624/anesthetic-management-of-two-parturients-with-cerebral-palsy-and-prior-selective-dorsal-rhizotomy
#5
C M Aiudi, E E Sharpe, K W Arendt, J J Pasternak, H P Sviggum
Selective dorsal rhizotomy is a surgical spine procedure used to reduce spasticity in patients with upper motor neuron dysfunction caused by conditions such as cerebral palsy. The optimal anesthetic approach for obstetric patients who have undergone a selective dorsal rhizotomy is unknown. The use and efficacy of neuraxial anesthesia in these patients has not been described. We describe the use of neuraxial anesthesia in two patients with prior selective dorsal rhizotomy. Unless contraindicated for other reasons, a neuraxial anesthetic approach appears to be an effective option in patients with a history of a selective dorsal rhizotomy...
December 15, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29352612/biogeographical-patterns-of-bacterial-and-archaeal-communities-from-distant-hypersaline-environments
#6
M Del R Mora-Ruiz, A Cifuentes, F Font-Verdera, C Pérez-Fernández, M E Farias, B González, A Orfila, R Rosselló-Móra
Microorganisms are globally distributed but new evidence shows that the microbial structure of their communities can vary due to geographical location and environmental parameters. In this study, 50 samples including brines and sediments from Europe, Spanish-Atlantic and South America were analysed by applying the operational phylogenetic unit (OPU) approach in order to understand whether microbial community structures in hypersaline environments exhibited biogeographical patterns. The fine-tuned identification of approximately 1000 OPUs (almost equivalent to "species") using multivariate analysis revealed regionally distinct taxa compositions...
December 21, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29352594/systematic-review-of-uterine-artery-embolisation-practice-guidelines-are-all-the-guidelines-on-the-same-page
#7
H T Chen, S Athreya
AIM: To evaluate the degree of concordance amongst the currently available guidelines informing the use of uterine artery embolisation (UAE), and identify any inconsistencies present. MATERIALS AND METHODS: Standards of practice and quality improvement guidelines were retrieved through a search of PubMed and EMBASE. Additional sets of guidelines were retrieved directly from the websites of known obstetrics and gynaecology and radiological associations. RESULTS: Eleven guidelines were retrieved from organisations located in Europe, North America, and Australia...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29352588/pulmonary-reinterventions-after-complete-unifocalization-and-repair-in-infants-and-young-children-with-tetralogy-of-fallot-with-major-aortopulmonary-collaterals
#8
Holly Bauser-Heaton, Alejandro Borquez, Ritu Asija, Lisa Wise-Faberowski, Yulin Zhang, Laura Downey, Stanton B Perry, Andrew Koth, Lynn F Peng, Claudia A Algaze, Frank L Hanley, Doff B McElhinney
BACKGROUND: Our institutional approach to tetralogy of Fallot (TOF) with major aortopulmonary collaterals (MAPCAs) emphasizes unifocalization and augmentation of the reconstructed pulmonary arterial (PA) circulation and complete intracardiac repair in infancy, usually in a single procedure. This approach yields a high rate of complete repair with excellent survival and low right ventricular (RV) pressure. However, little is known about remodeling of the unifocalized and reconstructed pulmonary circulation or about reinterventions on the reconstructed PAs or the RV outflow tract conduit...
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29352586/the-impact-of-enhanced-recovery-after-surgery-eras-protocol-compliance-on-morbidity-from-resection-for-primary-lung-cancer
#9
Luke J Rogers, David Bleetman, David E Messenger, Natasha A Joshi, Lesley Wood, Neil J Rasburn, Timothy J P Batchelor
OBJECTIVE: The adoption of Enhanced Recovery After Surgery programs in thoracic surgery is relatively recent with limited outcome data. This study aimed to determine the impact of an Enhanced Recovery After Surgery pathway on morbidity and length of stay in patients undergoing lung resection for primary lung cancer. METHODS: This prospective cohort study collected data on consecutive patients undergoing lung resection for primary lung cancer between April 2012 and June 2014 at a regional referral center in the United Kingdom...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29352575/double-plication-for-spring-mediated-intestinal-lengthening-of-a-defunctionalized-roux-limb
#10
Genia Dubrovsky, Nhan Huynh, Anne-Laure Thomas, Shant Shekherdimian, James C Y Dunn
BACKGROUND: Spring-mediated distraction enterogenesis has been shown to increase the length of an intestinal segment. The goal of this study is to use suture plication to confine a spring within an intestinal segment while maintaining luminal patency to the rest of the intestine. METHODS: Juvenile mini-Yucatan pigs underwent placement of nitinol springs within a defunctionalized Roux limb of jejunum. A 20 French catheter was passed temporarily, and sutures were used to plicate the intestinal wall around the catheter at both ends of the encapsulated spring...
December 26, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#11
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
INTRODUCTION: Post Vasectomy Pain Syndrome (PVPS) is an uncommon urologic problem that remains a challenge to manage. We aim to evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for PVPS at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon from March 2002 to October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients and success was defined as NRS ≤1 for >4 hours...
January 20, 2018: BJU International
https://www.readbyqxmd.com/read/29352514/an-integrative-review-exploring-the-physical-and-psychological-harm-inherent-in-using-restraint-in-mental-health-inpatient-settings
#12
Pauline Cusack, Frank Patrick Cusack, Sue McAndrew, Mick McKeown, Joy Duxbury
In Western society, policy and legislation seeks to minimize restrictive interventions, including physical restraint; yet research suggests the use of such practices continues to raise concerns. Whilst international agreement has sought to define physical restraint, diversity in the way in which countries use restraint remains disparate. Research to date has reported on statistics regarding restraint, how and why it is used, and staff and service user perspectives about its use. However, there is limited evidence directly exploring the physical and psychological harm restraint may cause to people being cared for within mental health inpatient settings...
January 19, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29352461/clinical-and-microbiological-evaluation-of-the-effect-of-lactobacillus-reuteri-in-the-treatment-of-mucositis-and-peri-implantitis-a-triple-blind-randomized-clinical-trial
#13
M Galofré, D Palao, M Vicario, J Nart, D Violant
BACKGROUND AND OBJECTIVE: Oral probiotics appear to improve the treatment of periodontal diseases but there is limited evidence on their efficacy in the treatment of peri-implant diseases. The objective of the present study was to evaluate, clinically and microbiologically, the effect of the oral probiotic, Lactobacillus reuteri Prodentis, as adjuvant to non-surgical mechanical therapy in implants with mucositis or peri-implantitis, placed in patients with a history of periodontal disease...
January 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29352439/single-incision-laparoscopic-transgastric-underrunning-and-closure-of-cameron-ulcers-in-acute-gastrointestinal-bleeding
#14
Chun Han Nigel Tan, Guowei Kim, Jimmy So, Asim Shabbir
INTRODUCTION: Endoscopic therapy remains the cornerstone of hemostasis for gastrointestinal bleeding. In situations where hemostasis cannot be achieved via endoscopic or radiological methods, surgery is necessary. Traditional open surgery for bleeding gastric ulcers can be very morbid and unsuitable especially in hemodynamically unstable patients in extremis. We describe a minimally invasive, transgastric approach for underrunning and closure of Cameron ulcers. METHODS: Our patient is a 75-year-old Chinese lady, who presented to the emergency department with fresh melena...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352436/posterolateral-tibial-plateau-fractures-how-to-buttress-reversed-l-posteromedial-or-the-posterolateral-approach-a-comparative-cadaveric-study
#15
Wich Orapiriyakul, Theerachai Apivatthakakul, Chanakarn Phornphutkul
INTRODUCTION: The selection of a surgical approach for buttressing posterolateral tibial plateau fractures is controversial. OBJECTIVE: This study compared the surgical exposure area between the reversed L posteromedial approach (R-PM) and the posterolateral (PL) approach using the lateral plateau width as a metric. MATERIALS AND METHODS: Twenty lower extremities from fresh frozen cadavers were included. The R-PM approach was used first and the boundary of the posterior tibial cortex exposure was marked with metal pins...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352421/predictors-of-insulin-initiation-in-patients-with-type-2-diabetes-an-analysis-of-the-look-ahead-randomized-trial
#16
Scott J Pilla, Hsin-Chieh Yeh, Stephen P Juraschek, Jeanne M Clark, Nisa M Maruthur
BACKGROUND: The decision to initiate insulin in patients with type 2 diabetes is a challenging escalation of care that requires an individualized approach. However, the sociodemographic and clinical factors affecting insulin initiation are not well understood. OBJECTIVE: We sought to identify patient factors that were independent predictors of insulin initiation among participants in the Look AHEAD (Action for Health in Diabetes) clinical trial. DESIGN: Retrospective analysis of a randomized clinical trial...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352409/recent-perspectives-on-the-molecular-basis-of-biofilm-formation-by-pseudomonas-aeruginosa-and-approaches-for-treatment-and-biofilm-dispersal
#17
REVIEW
Sinosh Skariyachan, Vaishnavi Sneha Sridhar, Swathi Packirisamy, Supreetha Toplar Kumargowda, Sneha Basavaraj Challapilli
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread diseases in humans. This bacterium is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteriaemia especially in immunocompromised patients. The current review focuses on the recent perspectives on biofilms formation by these bacteria. Biofilms are communities of microorganisms in which cells stick to each other and often adhere to a surface. These adherent cells are usually embedded within a self-produced matrix of extracellular polymeric substance (EPS)...
January 19, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29352405/virus-particle-detection-by-convolutional-neural-network-in-transmission-electron-microscopy-images
#18
Eisuke Ito, Takaaki Sato, Daisuke Sano, Etsuko Utagawa, Tsuyoshi Kato
A new computational method for the detection of virus particles in transmission electron microscopy (TEM) images is presented. Our approach is to use a convolutional neural network that transforms a TEM image to a probabilistic map that indicates where virus particles exist in the image. Our proposed approach automatically and simultaneously learns both discriminative features and classifier for virus particle detection by machine learning, in contrast to existing methods that are based on handcrafted features that yield many false positives and require several postprocessing steps...
January 19, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29352400/project-date-smart-a-dating-violence-dv-and-sexual-risk-prevention-program-for-adolescent-girls-with-prior-dv-exposure
#19
Christie J Rizzo, Meredith Joppa, David Barker, Charlene Collibee, Caron Zlotnick, Larry K Brown
This study assessed the initial feasibility, acceptability, and efficacy of an intervention aimed at reducing dating violence and sexual risk behavior in a sample of adolescent girls (ages 14-17) with prior exposure to physical dating violence (DV). One hundred and nine girls were randomly assigned to Date SMART (Skills to Manage Aggression in Relationships for Teens) or a Knowledge-only (KO) comparison group. Both intervention arms consisted of six, weekly 2-h sessions and one "booster" session 6 weeks later...
January 20, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29352393/eco-friendly-pheromone-dispensers-a-green-route-to-manage-the-european-grapevine-moth
#20
Andrea Lucchi, Edith Ladurner, Andrea Iodice, Francesco Savino, Renato Ricciardi, Francesca Cosci, Giuseppe Conte, Giovanni Benelli
The development of environmentally sustainable control strategies to fight insect pests is a key challenge nowadays. Pheromone-mediated mating disruption (MD) is based on the release of synthetic sex attractants into a crop, interfering with mate finding of a given pest species. However, a limited number of research items have been published on the optimization of MD strategies against the European grapevine moth, Lobesia botrana, as well as on the use of biodegradable dispensers to reduce waste production in vineyards, despite the high economic importance of this pest...
January 19, 2018: Environmental Science and Pollution Research International
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