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https://www.readbyqxmd.com/read/27639644/overexpression-of-pro-gastrin-releasing-peptide-promotes-the-cell-proliferation-and-progression-in-small-cell-lung-cancer
#1
Zhiyun Gong, Renquan Lu, Suhong Xie, Minglei Jiang, Kai Liu, Ran Xiao, Jiabin Shen, Yanchun Wang, Lin Guo
Pro-gastrin releasing peptide (ProGRP) plays the role of oncogene in small cell lung cancer (SCLC). In this study, we aim to explore the biological function of ProGRP in SCLC cells and its potential mechanism. Expression of ProGRP in SCLC tissues and cell lines were detected by immunohistochemistry and western blot analysis, respectively. The transduced cell lines with ProGRP down-regulation were established using RNA interference technology. Cell viability, cologenic, apoptosis-associated assay and the biomarker levels determination for cell supernatant were performed in the transduced cells to elucidate the biological functions and mechanisms of ProGRP in SCLC cells...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27186419/quercetin-induces-bladder-cancer-cells-apoptosis-by-activation-of-ampk-signaling-pathway
#2
Qiongli Su, Mei Peng, Yuqing Zhang, Wanjun Xu, Kwame Oteng Darko, Ting Tao, Yanjun Huang, Xiaojun Tao, Xiaoping Yang
Quercetin, a natural existing polyphenol compound, has shown anticancer capacity for liver, breast, nasopharyngeal and prostate carcinoma but has not been clinically approved yet. This might be due to lack of clear mechanistic picture. Bladder cancer is one of the most common cancers of the urinary tract in the world. In China, bladder cancer has the highest rate of incidence out of all malignancies of the urinary system. The anticancer application of quercetin on bladder cancer has not been investigated either...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/26802022/high-efficacy-of-intravesical-treatment-of-metformin-on-bladder-cancer-in-preclinical-model
#3
Mei Peng, Qiongli Su, Qing Zeng, Le Li, Zhihong Liu, Lei Xue, Yan Cheng, Yanjun Huang, Ting Tao, Hongwei Lv, Xiaohui Li, Xiaojun Tao, Peng Guo, Alex F Chen, Xiaoping Yang
Anticancer potential of metformin has been extensively studied. However, its anticancer clinical use remains yet to be approved since sufficient concentration on target organs could not be achieved via conventional administration. To overcome this drawback, we aim to examine the efficiency of novel intravesical treatment of metformin on syngeneic orthotopic preclinical model. Three human and one murine bladder cancer cell lines were tested in vitro for inhibitory sensitivity by MTT and cologenic assays. AMPK pathway including AKT, Erk and S6K was examined by western blot and further explored by regulating activated levels using specific inhibitors...
February 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/25921180/sirt7-exhibits-oncogenic-potential-in-human-ovarian-cancer-cells
#4
Hong-Ling Wang, Ren-Quan Lu, Su-Hong Xie, Hui Zheng, Xue-Mei Wen, Xiang Gao, Lin Guo
BACKGROUND: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. There is some evidence that SIRT7 may function as a tumor trigger for human malignancy. Here, we aimed to explore the biological function of SIRT7 in ovarian carcinoma cells and its potential mechanism. MATERIALS AND METHODS: Expression of SIRT7 in ovarian cancer cell lines was detected by western blotting...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/24792664/isolation-and-identification-of-epithelial-and-stromal-stem-cells-from-eutopic-endometrium-of-women-with-endometriosis
#5
T Li, H He, R Liu, S-X Wang, D-M Pu
OBJECTIVE: The recent characterization of possible stem/progenitor cells in the endometrium has shed new light on the origins of ectopic endometrial tissue and the mechanism for the pathogenesis of endometriosis, but has raised new questions. Is it possible that abnormal endometrial stem/progenitor cells increase their capacity to implant and establish themselves as ectopic tissue, or that normal stem cells implant in abnormal peritoneum? This study investigated key stem cell properties in cologenic epithelial and stromal cells obtained from eutopic endometrium of women with endometriosis...
July 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/23906794/a-novel-mechanism-of-xiap-degradation-induced-by-timosaponin-aiii-in-hepatocellular-carcinoma
#6
Ning Wang, Yibin Feng, Meifen Zhu, Fung-Ming Siu, Kwan-Ming Ng, Chi-Ming Che
Inducing tumor cell death is one of the major therapeutic strategies in treating cancer. The aim of this study is to investigate the mechanism underlying the involvement of autophagy in cell death induced by timosaponin AIII (TAIII). Cell viability was determined by MTT and cologenic assay; apoptosis was determined by flow cytometry and TUNEL assay; autophagy was examined by immunoblotting and immunofluorescence; ubiquitination was detected by co-immunoprecipitation; mRNA expression was detected by real-time PCR; and determination of necrotic cell death was approached with LDH assay...
December 2013: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23881868/the-lectin-of-dolichos-biflorus-agglutinin-recognises-glycan-epitopes-on-the-surface-of-a-subset-of-cardiac-progenitor-cells
#7
Zhanfeng Chen, Man Wang, Qiang Xiang, Zhenliang Sun, Rong Zhang
The discovery of adult cardiac progenitor cells (CPCs) provides a promising way for treating heart disease; however, their surface characteristics that play a critical role in regulating their maintenance, self-renewal, migration, and differentiation have not been fully investigated. One subpopulation of Dolichos biflorus agglutinin (DBA)-positive cells was identified in the heart of adult mice. Flow cytometry showed that 3.7% of heart cells could be labeled by FITC conjugated DBA. BrdU pulse-chase showed that 55-75% of DBA(+) cells were CPCs...
November 2013: Cell Biology International
https://www.readbyqxmd.com/read/23317192/differential-protein-expression-profile-between-cd20-positive-and-negative-cells-of-the-nci-h929-cell-line
#8
COMPARATIVE STUDY
Chuan-Ying Geng, Nian Liu, Guang-Zhong Yang, Ai-Jun Liu, Yun Leng, Hui-Juan Wang, Li-Hong Li, Yin Wu, Yan-Chen Li, Wen-Ming Chen
At present, multiple myeloma (MM) remains an incurable disease and cologenic cells may be responsible for disease relapse. It has been proposed that CD20+/CD138- NCI-H929 cells could be hallmarks of MM clonogenic cells. Here, the immunology phenotype of NCI-H929 cells is described. Only a small population of CD20+/CD138- cells (<1%) was found in the NCI-H929 cell line, but CD20+/CD138- cells were not detected. We found that CD20+/CD138+ cells were able to exhibit cologenic capacity by colony formation assay and continuous passage culture...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/22158035/proyl-isomerase-pin1-facilitates-ubiquitin-mediated-degradation-of-cyclin-dependent-kinase-10-to-induce-tamoxifen-resistance-in-breast-cancer-cells
#9
P Khanal, H J Yun, S C Lim, S G Ahn, H E Yoon, K W Kang, R Hong, H S Choi
Endocrine therapies that inhibit estrogen receptor (ER)-α signaling are the most common and effective treatment for ER-α-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The aim of this study was to elucidate the mechanisms by which downregulation of CDK10 expression confers resistance to tamoxifen in breast cancer. Here, we show that peptidyl-prolyl isomerase Pin1 downregulates CDK10 protein as a result of its interaction with and ubiquitination of CDK10, thereby affecting CDK10-dependent Raf-1 phosphorylation (S338)...
August 23, 2012: Oncogene
https://www.readbyqxmd.com/read/21871295/characterization-of-novel-synthesized-small-molecular-compounds-against-non-small-cell-lung-cancer
#10
COMPARATIVE STUDY
Yunge Zhao, Mark Turlington, Damien J LaPar, David R Jones, David A Harris, Irving L Kron, Lin Pu, Christine L Lau
BACKGROUND: With the exception of surgery, the standard platinum-based chemotherapeutic agents are the preferred treatment for non-small cell lung cancer (NSCLC); however little improvement (5-year survival) has been made. Therefore it is highly desirable to develop innovative therapeutic agents for NSCLC treatment. METHODS: Highly enantioselective synthetic methods were developed and a broad compound library was established. Cell toxicity, cell sensitivity, cell proliferation, cell invasion, and three-dimensional colony formation assays were used to assess the anticancer potential of these compounds in non-small-cell lung cancer (NSCLC) cell lines...
September 2011: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/21378707/-surgical-treatment-of-chronic-coprostasis
#11
E A Dzhavadov, F S Kurbanov
Surgical treatment of 27 patients with chronic colostasis and dolichocolon was analyzed. Groups of patients with cologenic and proctogenic colostasis were defined, diagnostic criteria were formulated and optimal surgical tactics were described for each group. Short and long-term results were analyzed and proved to be excellent and satisfactory in majority of patients.
2011: Khirurgiia
https://www.readbyqxmd.com/read/21164423/-surgical-treatment-of-chronic-colostasis
#12
E A Dzhavadov, F S Kurbanov, Iu N Tkachenko
Surgical treatment of 27 patients with chronic colostasis and dolichocolon was analyzed. Groups of patients with cologenic and proctogenic colostasis were defined, diagnostic criteria were formulated and optimal surgical tactics were described for each group. Short and long-term results were analyzed and proved to be excellent and satisfactory in majority of patients.
2010: Khirurgiia
https://www.readbyqxmd.com/read/21029583/-killing-effect-of-low-intensity-ultrasound-on-human-lung-cancer-cells-in-vitro
#13
X Zhan, Y Wang, B Lai
BACKGROUND: To investigate the effects of low intensity ultrasound on human lung cancer cells. METHODS: The human small cell lung cancer cells line SM, adenocarcinoma cell line A2 and human lung fibroblast cells FB were treated with low intensity ultrasound, and the killing effects of ultrasound on the cells were detected by the trypan blue exclusion and clonogenic survival assay. RESULTS: The killing effects of low intensity ultrasound ( 0...
December 20, 2000: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/20724974/-dolichocolon-as-a-reason-of-chronic-constipation
#14
E A Dzhavadov, F S Kurbanov, Iu N Tkachenko
53 patients with dolichocolon and chronic cologenic constipations were operated on. Results of comprehensive preoperative check-up, as well as results of surgical treatment were assessed. 88,7% of patients demonstrated good and satisfactory results. Active surgical tactics in respect of these patients, such as wider use of total colectomy and ileorectostomy is suggested.
2010: Khirurgiia
https://www.readbyqxmd.com/read/20614030/rb1cc1-activates-rb1-pathway-and-inhibits-proliferation-and-cologenic-survival-in-human-cancer
#15
Tokuhiro Chano, Kaichiro Ikebuchi, Yasuko Ochi, Hitosuke Tameno, Yasuhiko Tomita, Yufen Jin, Hideo Inaji, Makoto Ishitobi, Koji Teramoto, Ichiro Nishimura, Kahori Minami, Hirokazu Inoue, Takahiro Isono, Masao Saitoh, Taketoshi Shimada, Yasuo Hisa, Hidetoshi Okabe
RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) plays a role in the enhancement of the RB1 pathway through the direct binding to a GC-rich region 201bp upstream (from the initiation ATG) of the RB1 promoter. Here, we identified hSNF5 and p53 as the binding partners of RB1CC1 by immunoprecipitation and immunofluorescence assays. Interaction between these molecules and the RB1 pathway was analyzed by the assays of chromatin immunoprecipitation, luciferase-reporter, reverse transcription-polymerase chain reaction and immunoblot...
2010: PloS One
https://www.readbyqxmd.com/read/20479004/the-prolyl-isomerase-pin1-induces-lc-3-expression-and-mediates-tamoxifen-resistance-in-breast-cancer
#16
Gwang Mo Namgoong, Prem Khanal, Hae-Guk Cho, Sung-Chul Lim, Yoon Kyeong Oh, Bong Seok Kang, Jung-Hyun Shim, Jeong-Hyun Shim, Jin-Cheol Yoo, Hong Seok Choi
Endocrine therapies, which inhibit estrogen receptor signaling, are the most common and effective treatments for estrogen receptoralpha-positive breast cancer. However, the utility of these agents is limited by the frequent development of resistance, and the precise mechanisms underlying endocrine therapy resistance remain incompletely understood. Here, we demonstrate that peptidyl-prolyl isomerase Pin1 is an important determinant of resistance to tamoxifen and show that Pin1 increases E2F-4- and Egr-1-driven expression of LC-3 as a result of an increased interaction with and phosphorylation of MEK1/2...
July 30, 2010: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/19912438/human-ribosomal-protein-s13-promotes-gastric-cancer-growth-through-down-regulating-p27-kip1
#17
Xueyan Guo, Yongquan Shi, Yawen Gou, Jipeng Li, Shuang Han, Yanqi Zhang, Jianhua Huo, Xiaoxuan Ning, Li Sun, Yu Chen, Shiren Sun, Daiming Fan
Our previous works revealed that human ribosomal protein S13 (RPS13) was up-regulated in multidrug-resistant gastric cancer cells and overexpression of RPS13 could protect gastric cancer cells from drug-induced apoptosis. The present study was designed to explore the role of RPS13 in tumorigenesis and development of gastric cancer. The expression of RPS13 in gastric cancer tissues and normal gastric mucosa was evaluated by immunohistochemical staining and Western blot analysis. It was found RPS13 was expressed at a higher level in gastric cancer tissues than that in normal gastric mucosa...
February 2011: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/19668148/-antiperistaltic-cecorectal-anastomosis-by-subtotal-colectomy
#18
COMPARATIVE STUDY
V I Pomazkin
Results of 24 subtotal colectomies with antiperistaltic cecorectal anastomosis without colon ascendens and sigmoid dislocation were analyzed. 19 patients were operated on for cologenic chronic constipation (first group) and 5 earlier colostomized patients, who comprised the second group, had simultaneous reconstructive operation with pathologically altered colon removal. No postoperative complication were registered. 11 patients complained of diarrhea a month after the operation. Within 6 months an average defecation frequency was 1...
2009: Khirurgiia
https://www.readbyqxmd.com/read/18585854/isoflavones-and-gamma-irradiation-inhibit-cell-growth-in-human-salivary-gland-cells
#19
J Katz, E Blake, T A Medrano, Y Sun, K T Shiverick
UNLABELLED: We studied the effects of isoflavones and irradiation on cell cycle in a human salivary gland cell line (HSG). Genistein and a soy isoflavone conjugate (NS) inhibited DNA synthesis. Cells deconjugated the glucoside form of isoflavones in NS to the aglycones genistein and daidzein. NS, genistein and IR increased phosphorylation of p53 and p21 CIP1 at serine 15 (phos-p53). Irradiation and NS also increased levels of p21 CIP1. In a cologenic survival assay, cells in log phase growth had high radio-sensitivity with 2 Gy causing a reduction in survival (SF2=0...
October 18, 2008: Cancer Letters
https://www.readbyqxmd.com/read/17044997/-exogenous-pten-enhances-apoptosis-in-pancreas-cancer-cell-line-aspc-1-induced-by-hypoxia
#20
Jian-jun Li, Hong-yu Li, Yan-zhi Chen, Guang Li, Yan Xin
OBJECTIVE: To investigate the effect of exogenous phosphatase and tensin homologue deleted on chromosome ten (PTEN) on cell cycle, the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) proteins, and cellular proliferation ability in human pancreas cancer cell line (ASPC-1) exposed to normal oxygen or hypoxia 1% for 24 h were determined. METHODS: ASPC-1 cells were transfected in vitro with an eukaryotic expression plasmid (pEAK8) containing PTEN or not by lipofectin...
May 2006: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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