keyword
https://read.qxmd.com/read/38058676/management-and-treatment-of-children-young-people-and-adults-with-systemic-lupus-erythematosus-british-society-for-rheumatology-guideline-scope
#21
REVIEW
Md Yuzaiful Md Yusof, Eve M D Smith, Sammy Ainsworth, Kate Armon, Michael W Beresford, Morgan Brown, Lindsey Cherry, Christopher J Edwards, Kalveer Flora, Rebecca Gilman, Bridget Griffiths, Caroline Gordon, Paul Howard, David Isenberg, Natasha Jordan, Arvind Kaul, Peter Lanyon, Philip M Laws, Liz Lightsone, Hanna Lythgoe, Christian D Mallen, Stephen D Marks, Naomi Maxwell, Elena Moraitis, Clare Nash, Ruth J Pepper, Clarissa Pilkington, Antonios Psarras, Heather Rostron, Jade Skeates, Sarah Skeoch, Dalila Tremarias, Chris Wincup, Asad Zoma, Edward M Vital
The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood...
2023: Rheumatology Advances in Practice
https://read.qxmd.com/read/38055641/nutrition-assessment-and-mash-severity-in-children-using-the-healthy-eating-index
#22
JOURNAL ARTICLE
Ajay Kumar Jain, Paula Buchannan, Katherine P Yates, Patricia Belt, Jeffrey B Schwimmer, Philip Rosenthal, Karen F Murray, Jean P Molleston, Ann Scheimann, Stavra A Xanthakos, Cynthia A Behling, Paula Hertel, Jamie Nilson, Brent A Neuschwander-Tetri, James Tonascia, Miriam B Vos
BACKGROUND: Pediatric metabolic-associated fatty liver disease (MAFLD) is a global health problem, with lifestyle modification as its major therapeutic strategy. Rigorous characterization of dietary content on MAFLD in children is lacking. We hypothesized an objectively measured healthier diet would positively modulate MAFLD. METHODS: Diet was assessed using the Nutrition Data System for Research in children enrolled from 10 tertiary clinical centers to determine the Healthy Eating Index (HEI, 0-100) and individual food components...
December 1, 2023: Hepatology Communications
https://read.qxmd.com/read/37989929/effects-of-zinc-supplementation-on-inflammatory-status-and-nonalcoholic-steatohepatitis-in-overweight-or-obese-children-a-randomized-clinical-trial
#23
JOURNAL ARTICLE
Vahidreza Ostadmohammadi, Mohammad Javad Namazi, Mahsa Rezasoltani, Davood Kheirkhah, Mohammad Rajabi, Alireza Sharif, Abbas Taghavi Ardakani, Fariba Raygan, Amelia A Assareh, Mohammad Reza Sharif
The purpose of the present clinical trial was to determine the impact of zinc supplementation on serum liver enzymes, steatosis severity, lipid profile, and inflammatory status in overweight or obese children with nonalcoholic steatohepatitis (NASH). This randomized controlled trial was conducted by enrolling 60 children with NASH, aged 10-18 years old. The participants were randomly assigned to two groups that received either 30 mg/day of elemental zinc or placebo for 16 weeks. The severity of liver steatosis was evaluated using liver ultrasonography...
November 22, 2023: Biological Trace Element Research
https://read.qxmd.com/read/37927726/non-alcoholic-fatty-liver-in-children-and-adolescents-in-saudi-arabia
#24
JOURNAL ARTICLE
Gadah Mujlli, Moeber Mahzari, Ibrahim Alslamah, Jamil Syed, Aamir Omair, Mahumoud Abulmeaty, Dara Aldisi
Objectives This study aims to describe the disease parameters of children and adolescents diagnosed with non-alcoholic fatty liver disease (NAFLD) in Saudi Arabia. It also investigates the disease's progression and compares clinical, biochemical, and radiological parameters at baseline and follow-up of patients with NAFLD. This study was done between two groups of patients: obese and those of average body weight.  Methods A retrospective cohort study was conducted between 2014 and 2018 through retrieved data from medical records...
October 2023: Curēus
https://read.qxmd.com/read/37870272/development-of-fibro-pen-a-clinical-prediction-model-for-moderate-to-severe-fibrosis-in-children-with-nonalcoholic-fatty-liver-disease
#25
JOURNAL ARTICLE
Andrew Wang, Amanda L Blackford, Cynthia Behling, Laura A Wilson, Kimberly P Newton, Stavra A Xanthakos, Mark H Fishbein, Miriam B Vos, Marialena Mouzaki, Jean P Molleston, Ajay K Jain, Paula Hertel, Kathryn Harlow Adams, Jeffrey B Schwimmer
BACKGROUND AND AIMS: Liver fibrosis is common in children with nonalcoholic fatty liver disease (NAFLD) and an important determinant of outcomes. High performing non-invasive models to assess fibrosis in children are needed. The objectives of this study were to evaluate the performance of existing pediatric and adult fibrosis prediction models and to develop a clinical prediction rule for identifying moderate-to-severe fibrosis in children with NAFLD. APPROACH AND RESULTS: We enrolled children with biopsy-proven NAFLD in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) within 90 days of liver biopsy...
October 23, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/37857476/applying-the-antecedent-behaviour-and-consequence-taxonomy-to-unintentional-firearm-injury-as-determined-by-a-collaborative-firearm-injury-database
#26
JOURNAL ARTICLE
William B Risinger, Alexis K Nickols, Alexis N Harris, Matthew V Benns, Nicholas A Nash, Matthew C Bozeman, Samuel J Pera, Jamie C Coleman, Glen A Franklin, Jason W Smith, Brian G Harbrecht, Keith R Miller
BACKGROUND: Unintentional firearm injury (UFI) remains a significant problem in the USA with respect to preventable injury and death. The antecedent, behaviour and consequence (ABC) taxonomy has been used by law enforcement agencies to evaluate unintentional firearm discharge. Using an adapted ABC taxonomy, we sought to categorise civilian UFI in our community to identify modifiable behaviours. METHODS: Using a collaborative firearm injury database (containing both a university-based level 1 trauma registry and a metropolitan law enforcement database), all UFIs from August 2008 through December 2021 were identified...
October 19, 2023: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://read.qxmd.com/read/37813178/application-habits-and-practices-of-regular-sunscreen-users-in-the-united-states-results-of-an-online-survey
#27
JOURNAL ARTICLE
Kimberly G Norman, Linda Loretz, Alexandra Kowcz, Lewis E Kaufman, Eduardo Ruvolo, Michael Traudt, Idalina Santos, Rachel RoseMansfield, J Frank Nash
A nationwide online survey assessed claimed usage of sunscreen products in 2283 self-identified regular sun protection factor (SPF) consumers (RSPFC) in the United States. Subjects applied sunscreen most frequently when spending more than 3 h in the sun. Sunscreen usage peaks during the summer, with sunny weather prompting 99% usage of beach/recreational SPF products but drops to approximately 50% and 30% on partly cloudy and cloudy days, respectively, regardless of SPF product category. About half of RSPFC augment sunscreen product usage by limiting time in the sun and wearing a hat...
October 7, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/37730290/chronic-medication-burden-after-cardiac%C3%A2-surgery-for-pediatric-medicaid%C3%A2-beneficiaries
#28
JOURNAL ARTICLE
Joyce L Woo, Katherine A Nash, Kacie Dragan, Sarah Crook, Matthew Neidell, Stephen Cook, Edward L Hannan, Marshall Jacobs, Andrew B Goldstone, Christopher J Petit, Robert Vincent, Kathleen Walsh-Spoonhower, Ralph Mosca, T K Susheel Kumar, Neil Devejian, Steven A Kamenir, George M Alfieris, Michael F Swartz, David Meyer, Erin A Paul, Jane W Newburger, John Billings, Matthew M Davis, Brett R Anderson
BACKGROUND: Congenital heart defects are the most common and resource-intensive birth defects. As children with congenital heart defects increasingly survive beyond early childhood, it is imperative to understand longitudinal disease burden. OBJECTIVES: The purpose of this study was to examine chronic outpatient prescription medication use and expenditures for New York State pediatric Medicaid enrollees, comparing children who undergo cardiac surgery (cardiac enrollees) and the general pediatric population...
September 26, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37643935/nonalcoholic-fatty-liver-disease-and-adult-growth-hormone-deficiency-an-under-recognized-association
#29
REVIEW
Yutaka Takahashi
Growth hormone (GH) plays an essential role not only in promoting growth in children, but also in many important metabolic processes in adults. One of the major metabolic functions of GH is its stimulatory effects on the liver in generating approximately 80% of circulating insulin-like growth factor 1 (IGF-1). Adult growth hormone deficiency (GHD) is an established clinical entity defined as a defect in endogenous GH secretion that is frequently associated with central obesity, loss of muscle mass, decreased bone mass, and impaired quality of life...
August 16, 2023: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/37633900/dorsal-visual-stream-and-limk1-hemideletion-haplotype-and-enduring-effects-in-children-with-williams-syndrome
#30
JOURNAL ARTICLE
J Shane Kippenhan, Michael D Gregory, Tiffany Nash, Philip Kohn, Carolyn B Mervis, Daniel P Eisenberg, Madeline H Garvey, Katherine Roe, Colleen A Morris, Bhaskar Kolachana, Ariel M Pani, Leah Sorcher, Karen F Berman
BACKGROUND: Williams syndrome (WS), a rare neurodevelopmental disorder caused by hemizygous deletion of ~ 25 genes from chromosomal band 7q11.23, affords an exceptional opportunity to study associations between a well-delineated genetic abnormality and a well-characterized neurobehavioral profile. Clinically, WS is typified by increased social drive (often termed "hypersociability") and severe visuospatial construction deficits. Previous studies have linked visuospatial problems in WS with alterations in the dorsal visual processing stream...
August 26, 2023: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/37583647/comparative-analysis-of-global-hepatic-gene-expression-in-adolescents-and-adults-with-non-alcoholic-fatty-liver-disease
#31
JOURNAL ARTICLE
Samer Gawrieh, Rebekah Karns, David E Kleiner, Michael Olivier, Todd Jenkins, Thomas H Inge, Naga P Chalasani, Stavra Xanthakos
INTRODUCTION: To gain insights into the mechanisms underlying distinct nonalcoholic fatty liver disease (NAFLD) histological phenotypes between children and adults, we compared hepatic gene expression profiles associated with NAFLD phenotypes between the two age groups. METHODS: Histological characteristics of intra-operative liver biopsies from adolescents and adults undergoing bariatric surgery were assessed by the same pathologist using the non-alcoholic steatohepatitis (NASH) Clinical Research Network scoring system...
2023: Archives of clinical and biomedical research
https://read.qxmd.com/read/37441655/mental-health-knowledge-and-classroom-experiences-of-school-teachers-in-aragon-spain
#32
JOURNAL ARTICLE
José Manuel Granada-López, Enrique Ramón-Arbués, Emmanuel Echániz-Serrano, Raúl Juárez-Vela, Ana Cobos-Rincón, Pedro José Satústegui-Dordá, Noelia Navas-Echazarreta, Iván Santolalla-Arnedo, Michael Nash
BACKGROUND: Research shows that many mental disorders begin in childhood but are sometimes not diagnosed until later years. School-age children spend much of their time in schools and have daily interactions with school teachers. AIM: Examine school teachers' experiences of mental disorders in school going children and adolescents and their associated mental health training needs. METHOD AND SAMPLE: A descriptive cross-sectional study was carried out with teachers in Infant-Primary and Secondary Education-Baccalaureate schools...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37414616/snp-chromosome-microarray-genotyping-for-detection-of-uniparental-disomy-in-the-clinical-diagnostic-laboratory
#33
JOURNAL ARTICLE
Con Ngo, Maria Baluyot, Bruce Bennetts, Johanna Carmichael, Alissa Clark, Artur Darmanian, Thet Gayagay, Luke Jones, Benjamin Nash, Melanie Clark, Ngaire Jose, Samantha Robinson, Luke St Heaps, Dale Wright
Single nucleotide polymorphism (SNP) chromosome microarray is well established for investigation of children with intellectual deficit/development delay and prenatal diagnosis of fetal malformation but has also emerged for uniparental disomy (UPD) genotyping. Despite published guidelines on clinical indications for testing there are no laboratory guidelines published for performing SNP microarray UPD genotyping. We evaluated SNP microarray UPD genotyping using Illumina beadchips on family trios/duos within a clinical cohort (n=98) and then explored our findings in a post-study audit (n=123)...
June 16, 2023: Pathology
https://read.qxmd.com/read/37353401/a-global-research-priority-agenda-to-advance-public-health-responses-to-fatty-liver-disease
#34
JOURNAL ARTICLE
Jeffrey V Lazarus, Henry E Mark, Alina M Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N Brennan, Patrizia Burra, Graciela E Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M Francque, Hannes Hagström, Terry T-K Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J Kopka, Aleksander Krag, Veronica Miller, Philip N Newsome, Mary E Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C Wendy Spearman, Emmanuel A Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jörn M Schattenberg, Vincent Wai-Sun Wong, Zobair M Younossi
BACKGROUND & AIMS: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. METHODS: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting...
September 2023: Journal of Hepatology
https://read.qxmd.com/read/37313635/a-delphi-study-exploring-the-barriers-to-dyslexia-diagnosis-and-support-a-parent-s-perspective
#35
JOURNAL ARTICLE
Sophie Harding, Maya Chauhan-Sims, Emily Oxley, Hannah M Nash
The Rose Report (Rose, Independent review of the primary curriculum (England); 2009) outlined a set of recommendations for the management of dyslexia in the United Kingdom after a range of issues were found. Despite these recommendations, recent reports indicate that issues are still prevalent in the diagnosis process and support offered for dyslexic children. The Delphi method was employed to gain parental consensus as to the most significant barriers to diagnosis and delivery of support for children with dyslexia, as well as solutions to overcoming these barriers...
June 14, 2023: Dyslexia: the Journal of the British Dyslexia Association
https://read.qxmd.com/read/37305367/noninvasive-biomarkers-in-pediatric-nonalcoholic-fatty-liver-disease
#36
REVIEW
Dulshan Jayasekera, Phillipp Hartmann
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide among children and adolescents. It encompasses a spectrum of disease, from its mildest form of isolated steatosis, to nonalcoholic steatohepatitis (NASH) to liver fibrosis and cirrhosis, or end-stage liver disease. The early diagnosis of pediatric NAFLD is crucial in preventing disease progression and in improving outcomes. Currently, liver biopsy is the gold standard for diagnosing NAFLD. However, given its invasive nature, there has been significant interest in developing noninvasive methods that can be used as accurate alternatives...
May 27, 2023: World Journal of Hepatology
https://read.qxmd.com/read/37284808/effects-of-dietary-sugar-restriction-on-hepatic-fat-in-youth-with-obesity
#37
JOURNAL ARTICLE
Johanna K Distefano, Glenn S Gerhard
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children. Like adults, children can develop the progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), which is characterized by hepatic inflammation, often in the presence of fibrosis. Children with NAFLD are at higher risk of liver-related complications, metabolic dysfunction, and cardiovascular disease in adulthood. Many factors contribute to the escalating prevalence of NAFLD in the pediatric population, among which are an array of dietary patterns such as overnutrition, poor diet quality, and heavy consumption of fat and sugar, including fructose...
June 7, 2023: Minerva pediatrics
https://read.qxmd.com/read/37277341/monitoring-transmission-intensity-of-trachoma-with-serology
#38
JOURNAL ARTICLE
Christine Tedijanto, Anthony W Solomon, Diana L Martin, Scott D Nash, Jeremy D Keenan, Thomas M Lietman, Patrick J Lammie, Kristen Aiemjoy, Abdou Amza, Solomon Aragie, Ahmed M Arzika, E Kelly Callahan, Sydney Carolan, Adisu Abebe Dawed, E Brook Goodhew, Sarah Gwyn, Jaouad Hammou, Boubacar Kadri, Khumbo Kalua, Ramatou Maliki, Beido Nassirou, Fikre Seife, Zerihun Tadesse, Sheila K West, Dionna M Wittberg, Taye Zeru Tadege, Benjamin F Arnold
Trachoma, caused by ocular Chlamydia trachomatis infection, is targeted for global elimination as a public health problem by 2030. To provide evidence for use of antibodies to monitor C. trachomatis transmission, we collated IgG responses to Pgp3 antigen, PCR positivity, and clinical observations from 19,811 children aged 1-9 years in 14 populations. We demonstrate that age-seroprevalence curves consistently shift along a gradient of transmission intensity: rising steeply in populations with high levels of infection and active trachoma and becoming flat in populations near elimination...
June 5, 2023: Nature Communications
https://read.qxmd.com/read/37272169/-a-cross-sectional-study-on-the-prevalence-rate-and-influencing-factors-of-non-alcoholic-fatty-liver-disease-in-overweight-obese-children
#39
JOURNAL ARTICLE
Wen Dai, Zhen-Zhen Yao, Si-Si Ou-Yang, Ning-An Xu, Hai-Xiang Zhou, Xiong-Wei Li, Yan Zhong, Jia-You Luo
OBJECTIVES: To investigate the prevalence rate of non-alcoholic fatty liver disease (NAFLD) in overweight/obese children who visit a hospital, and to explore the influencing factors of NAFLD, in order to provide a basis for the prevention of NAFLD in overweight/obese children. METHODS: Overweight/obese children who visited Hunan Children's Hospital from June 2019 to September 2021 were recruited. The prevalence rate of NAFLD was examined. Logistic regression analysis was used to explore the factors influencing the development of NAFLD [non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH)]...
May 15, 2023: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/37209059/food-insecurity-during-the-first-year-of-covid-19-employment-and-sociodemographic-factors-among-participants-in-the-chasing-covid-cohort-study
#40
JOURNAL ARTICLE
Yvette Ng, Mindy Chang, McKaylee Robertson, Christian Grov, Andrew Maroko, Rebecca Zimba, Drew Westmoreland, Madhura Rane, Chloe Mirzayi, Angela M Parcesepe, Sarah Kulkarni, William Salgado-You, Nevin Cohen, Denis Nash
OBJECTIVE: While much has been reported about the impact of the COVID-19 pandemic on food insecurity, longitudinal data and the variability experienced by people working in various industries are limited. This study aims to further characterize people experiencing food insecurity during the pandemic in terms of employment, sociodemographic characteristics, and degree of food insecurity. METHODS: The study sample consisted of people enrolled in the Communities, Households and SARS-CoV-2 Epidemiology (CHASING) COVID Cohort Study from visit 1 (April-July 2020) through visit 7 (May-June 2021)...
May 20, 2023: Public Health Reports
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