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St. John wort

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https://www.readbyqxmd.com/read/29751080/prenylated-%C3%AE-diketones-two-new-additions-to-the-family-of-biologically-active-hypericum-perforatum-l-hypericaceae-secondary-metabolites
#1
Niko S Radulović, Marija S Genčić, Nikola M Stojanović, Pavle J Randjelović, Nicolas Baldovini, Vanya Kurteva
Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant Hypericum perforatum L. The structures of β-diketones A and B were corroborated by syntheses (4 steps starting from methyl acetoacetate, overall yields 30% and 23%, respectively). In solution, these β-diketones predominantly exist as two rapidly interconverting β-keto-enol tautomers. The structures of A and B show some common fragments with the molecules of hyperforin and adhyperforin, respectively, the acknowledged multi-target secondary metabolites from St...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29730986/-%C3%A2-decreased-everolimus-blood-concentration-associated-with-consumption-of-st-john-s-wort-hypericum-perforatum-extract-sweets%C3%A2
#2
Héctor Cristóbal Gutiérrez, Virginia Martínez-Callejo, Ana María García de la Paz, David Gómez-Gómez, María Ochagavía-Sufrategui, Marta Valero-Domínguez, M ª de Las Mercedes Colorado-Araujo, Elena Vejo-Puente
No abstract text is available yet for this article.
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29708295/the-safety-of-st-john-s-wort-hypericum-perforatum-in-pregnancy-and-lactation-a-systematic-review-of-rodent-studies
#3
REVIEW
Catharine Avila, Dawn Whitten, Sue Evans
Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Hence, animal studies often inform clinical decisions. The objective of this study is to systematically review rodent studies assessing the safety of SJW during the perinatal period. A literature search to November 10, 2017, identified 10 rodent studies that met a priori inclusion criteria...
April 30, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#4
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29665654/hypericin-affects-cancer-side-populations-via-competitive-inhibition-of-bcrp
#5
Jana Vargová, Jaromír Mikeš, Rastislav Jendželovský, Lucia Mikešová, Barbora Kuchárová, Ľubomír Čulka, Radek Fedr, Ján Remšík, Karel Souček, Alois Kozubík, Peter Fedoročko
OBJECTIVE: Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP assay relies on the elevated activity of ABC transporters that, in turn, can be modulated by hypericin (HYP), a photosensitizer and bioactive compound of St. John's Wort (Hypericum perforatum), a popular over-the-counter antidepressant. Here we aimed to comprehensively characterize the SP phenotype of cancer cells and to determine the impact of HYP on these cells...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29600756/potential-pharmacokinetic-herb-drug-interactions-have-we-overlooked-the-importance-of-human-carboxylesterases-1-and-2
#6
Jing Xu, Jin-Chun Qiu, Xing Ji, Hong-Li Guo, Xuan Wang, Bo Zhang, Tengfei Wang, Feng Chen
Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2...
March 30, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29575228/herbal-medicines-in-the-treatment-of-psychiatric-disorders-10-year-updated-review
#7
REVIEW
Jerome Sarris
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders...
March 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29570671/st-john-s-wort-regulates-proliferation-and-apoptosis-in-mcf-7-human-breast-cancer-cells-by-inhibiting-ampk-mtor-and-activating-the-mitochondrial-pathway
#8
Mi-Kyoung You, Hwa-Jin Kim, Ji Hyun Kook, Hyeon-A Kim
St. John's Wort (SJW) has been used as an estrogen agonist in the systems affected by menopause. Also, hypericin, a bioactive compound of SJW, has been used as a photosensitizer in photodynamic therapy. In the present study, we investigate the anti-proliferative and pro-apoptotic effects of SJW to demonstrate the chemo-preventive effect in human breast cancer cells. MCF-7 cells were cultured with DMSO or various concentrations of SJW ethanol extract (SJWE). Cell viability, proliferation, apoptosis, the expression of proteins involved in cell growth and apoptosis, and caspase-3/7 activity were examined...
March 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29557312/-a-multi-arm-placebo-controlled-study-with-glutamic-acid-conducted-in-rostock-in-1953-1954
#9
Frank Häßler, Steffen Weirich
A Multi-arm Placebo-controlled Study with Glutamic Acid Conducted in Rostock in 1953/1954 Glutamic acid was commonly used in the treatment of intellectually disabled children in the 50s. Koch reported first results of an observation of 140 children treated with glutamic acid in 1952. In this line is the multi-arm placebo-controlled study reported here. The original study protocols were available. 58 children with speech problems who attending a school of special needs received glutamic acid, or vitamin B, or St...
September 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29541484/acute-on-chronic-subdural-hematoma-in-a-patient-taking-red-clover-herbal-supplement-a-case-report
#10
Samuel Hall, Eleanor Walshe, Claudia Ajayi, Kevin Boyle, Colin Griffith
Background: Herbal supplements are commonly used, however, their side-effect profiles are poorly understood and not subject to the same scrutiny as prescribed medications. Some herbal supplements such as St Johns' Wort are accepted to interfere with clotting pathways, however others, including Red Clover have theoretical bleeding risks based on coumarin content with very little underlying evidence. Case Description: This case reports a 65-year-old woman who suffered a spontaneous acute-on-chronic subdural hemorrhage with a significant postoperative re-hemorrhage...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29523613/flupirtine-drug-induced-liver-injury-in-a-patient-developing-acute-liver-failure
#11
David Noiva Perdigoto, Pedro Amaro, Manuela Ferreira, Luis Tomé
A patient is admitted with complaints of recent onset nausea, discomfort, jaundice and blood tests that reveal severe hepatitis. At the time, she had been taking medication with Hypericum perforatum (St John's wort) for 6 months, and 6 weeks before this event, she took flupirtine maleate. A few days after being admitted, she developed encephalopathy progressing to acute liver failure (ALF) requiring unsuccessful liver transplantation. The patient was ultimately diagnosed with drug-induced liver injury (DILI)...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29499586/hyperforin-and-miquelianin-from-st-john-s-wort-attenuate-gene-expression-in-neuronal-cells-after-dexamethasone-induced-stress
#12
Sheela Verjee, Anna Weston, Christiane Kolb, Heba Kalbhenn-Aziz, Veronika Butterweck
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis plays an important part in the development of depressive symptoms. In this study, the effects of a commercial St. John's wort extract (STW3-VI), hyperforin, miquelianin, and the selective serotonin reuptake inhibitor citalopram on the expression of genes relevant to HPA axis function were investigated in human neuronal cells. SH-SY5Y cells were treated with STW3-VI (20 µg/mL), hyperforin (1 µM), miquelianin (10 µM), or citalopram (10 µM) in the presence of the glucocorticoid receptor agonist dexamethasone (DEX,10 µM) for 6 h and 48 h, respectively...
March 2, 2018: Planta Medica
https://www.readbyqxmd.com/read/29496168/st-john-s-wort-hypericum-perforatum-products-an-assessment-of-their-authenticity-and-quality
#13
Anthony Booker, Anastasia Agapouda, Débora A Frommenwiler, Francesca Scotti, Eike Reich, Michael Heinrich
BACKGROUND: St John's wort products (Hypericum perforatum L.) are widely available for sale in many countries including the UK via the internet. In the UK, these products are required to hold either a marketing authorisation or Traditional herbal registration (THR) to be sold legally. The THR and other regulatory schemes help to ensure product safety and quality providing an example of best practice but there is a risk if both regulated and un-regulated products continue to be available to consumers...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29489494/mineralocorticoid-receptor-related-markers-and-outcome-of-major-depression-focus-on-blood-pressure-and-electrolytes
#14
Harald Murck, Michael Ploch, Stuart Montgomery
A close association between vegetative regulation and affect is common knowledge. Recently, the role of aldosterone and the activity of its receptor [mineralocorticoid receptor (MR)] in the clinical outcome for treatment with standard antidepressants has been shown including low systolic blood pressure and a low concentration of plasma sodium (Na), both of which appear to be related to therapy resistance to standard antidepressants. We carried out a retrospective analysis of a double-blind placebo-controlled trial of St John's wort extract LI160 in 247 outpatients with major depression...
February 27, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29478534/activation-of-membrane-located-ca-2-channels-by-hop-beta-acids-and-their-tricyclic-transformation-products
#15
Carolin Schulz, Nikolas Fritz, Thomas Sommer, Karel Krofta, Kristina Friedland, Monika Pischetsrieder
Beta-bitter acids of hops (lupulones) revealed sedative and antidepressant-like effects in animal studies. Transformation of β-acids during beer brewing leads to the formation of tricyclic transformation products, which have a close structural analogy to hyperforin. The latter compound is responsible for the antidepressant activity of St. John's wort by activation of TRPC6 cation channels in neuronal-like cells leading to Ca2+ influx. In this study, nortricyclolupones, dehydrotricyclolupones, and tricyclolupones were isolated from a wort-boiling model and their structures were elucidated by UHPLC-DAD, UHPLC-ESI- -MS/MS and 1D/2D-NMR spectroscopy...
June 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29442047/comprehensive-phytochemical-characterization-of-st-john-s-wort-hypericum-perforatum-l-oil-macerates-obtained-by-different-extraction-protocols-via-analytical-tools-applicable-in-routine-control
#16
M Heinrich, R Daniels, F C Stintzing, D R Kammerer
The aim of the present study was to investigate the impact of crucial process parameters, i.e. of light and temperature conditions, during the preparation of St. John's wort (SJW, Hypericum perforatum L.) Arachis oil macerates. Extracts were prepared according to a standardized protocol over a period of 28 days. For this purpose, flowering tops of H. perforatum were macerated with Arachis oil (drug extract ratio, DERnative 1:4) under different light and temperature conditions. Spectrophotometric measurements were carried out to quantitate naphthodianthrones and to characterize extract color in the CIE L*C*h° system...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29411879/understanding-drug-interactions-with-st-john-s-wort-hypericum-perforatum-l-impact-of-hyperforin-content
#17
REVIEW
Sigrun Chrubasik-Hausmann, Julia Vlachojannis, Andrew J McLachlan
OBJECTIVE: The aim of this study was to review herb-drug interaction studies with St John's wort (Hypericum perforatum L.) with a focus on the hyperforin content of the extracts used in these studies. METHODS: PUBMED was systematically searched to identify studies describing pharmacokinetic interactions involving St John's wort. Data on study design and the St John's wort extract or product were gathered to extract hyperforin content and daily dose used in interaction studies...
February 7, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29389584/the-time-dependent-effects-of-st-john-s-wort-on-cytochrome-p450-uridine-diphosphate-glucuronosyltransferase-glutathione-s-transferase-and-nad-p-h-quinone-oxidoreductase-in-mice
#18
Jin-Fu Yang, Yue-Rong Liu, Chiung-Chiao Huang, Yune-Fang Ueng
Hypericum perforatum [St. John's wort (SJW)] is known to cause a drug interaction with the substrates of cytochrome P450 (P450, CYP) isoforms, mainly CYP3A. This study aims to determine the dose response and time course of the effects of SJW extract on P450s, UDP-glucuronosyltransferase (UGT), glutathione S-transferase (GST), and NAD(P)H-quinone oxidoreductase (NQO) in mice. The oral administration of SJW extract to male mice at 0.6 g/kg/d for 21 days increased hepatic oxidation activity toward a Cyp3a substrate nifedipine...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29353203/the-water-extract-of-tutsan-hypericum-androsaemum-l-red-berries-exerts-antidepressive-like-effects-and-in-vivo-antioxidant-activity-in-a-mouse-model-of-post-stroke-depression
#19
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Giovanni Caprioli, Romilde Iannarelli, Arold Jorel Tsetegho Sokeng, Nady Braidy, Sedigheh Khanjani, Akbar Hajizadeh Moghaddam, Atanas G Atanasov, Maria Daglia, Filippo Maggi
Hypericum androsaemum L., commonly known as 'tutsan' or 'shrubby St. John's Wort', is a member of the Hypericum genus found growing spontaneously in the Mediterranean area and is cultivated extensively as an ornamental plant due to the showy color variation in its fresh berry-like capsules, which turn from red to shiny black as they ripen. Tutsan has also been used in Portuguese and Spanish folk medicine to treat depression. In this study, we assessed the beneficial role of the water extract of H. androsaemum red berries (WE) in an experimental animal model of post-stroke depression...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29344343/the-role-of-selective-serotonin-reuptake-inhibitors-in-preventing-relapse-of-major-depressive-disorder
#20
REVIEW
Steven S Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, Waguih William IsHak
The objective of this review was to evaluate the efficacy of selective serotonin reuptake inhibitors (SSRIs) and SSRIs compared with other treatment modalities in preventing relapse after an episode of major depressive disorder (MDD). An Ovid MEDLINE and PsycINFO search (from 1987 to August 2017) was conducted using the following terms: selective serotonin reuptake inhibitors, antidepressants, depression, prevention, prophylaxis, relapse and MDD. Using predefined criteria, two authors independently selected and reached consensus on the included studies...
January 2018: Therapeutic Advances in Psychopharmacology
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