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St. John wort

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https://www.readbyqxmd.com/read/28700248/comparative-benefits-and-harms-of-complementary-and-alternative-medicine-therapies-for-initial-treatment-of-major-depressive-disorder-systematic-review-and-meta-analysis
#1
Gary N Asher, Gerald Gartlehner, Bradley N Gaynes, Halle R Amick, Catherine Forneris, Laura C Morgan, Emmanuel Coker-Schwimmer, Erin Boland, Linda J Lux, Susan Gaylord, Carla Bann, Christiane Barbara Pierl, Kathleen N Lohr
OBJECTIVES: To report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). DESIGN: Systematic review and meta-analysis. SETTINGS: Outpatient clinics. SUBJECTS: Adults, aged 18 years and older, with MDD receiving an initial treatment attempt with SGA. INTERVENTIONS: Any CAM or exercise intervention compared with an SGA...
July 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28683711/-decreased-everolimus-blood-concentration-associated-with-consumption-of-st-john-s-wort-hypericum-perforatum-extract-sweets
#2
Héctor Cristóbal Gutiérrez, Virginia Martínez Callejo, Ana María García de la Paz, David Gómez Gómez, María Ochagavía Sufrategui, Marta Valero Domínguez, M ª de Las Mercedes Colorado Araujo, Elena Vejo Puente
No abstract text is available yet for this article.
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28669795/downstream-processing-of-hyperforin-from-hypericum-perforatum-root-cultures
#3
Paul Haas, Mariam Gaid, Ajmal Zarinwall, Ludger Beerhues, Stephan Scholl
Hyperforin is a major metabolite of the medicinal plant Hypericum perforatum (St. John's Wort) and has recently been found in hormone induced root cultures. The objective of this study is to identify a downstream process for the production of a hyperforin-rich extract with maximum extraction efficiency and minimal decomposition. The maximum extraction time was found to be 60min. The comparison of two equipment concepts for the extraction and solvent evaporation was performed employing two different solvents...
June 29, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28653745/st-john-s-wort-for-depression-scoping-review-about-perceptions-and-use-by-general-practitioners-in-clinical-practice
#4
Kirsty Forsdike, Marie Pirotta
BACKGROUND: Extracts of Hypericum perforatum, more commonly known as St John's wort (SJW), have good evidence for treating depression. The herb is easily accessible and widely used by consumers, although it has potential for interaction with other medicines. Consumers' use of SJW is often not discussed with their general practitioners (GPs). It is unclear how GPs perceive use of SJW in practice and the implications for consumers and pharmacists. OBJECTIVE: Explore GPs' perception of SJW use in practice...
June 27, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28579821/opioid-analgesics-related-pharmacokinetic-drug-interactions-from-the-perspectives-of-evidence-based-on-randomized-controlled-trials-and-clinical-risk-management
#5
REVIEW
Xiu-Qin Feng, Ling-Ling Zhu, Quan Zhou
BACKGROUND: Multimorbidity results in complex polypharmacy which may bear a risk of drug interactions. A better understanding of opioid analgesics combination therapy used for pain management could help warrant medication safety, efficacy, and economic relevance. Until now there has been no review summarizing the opioid analgesics-related pharmacokinetic drug interactions from the perspective of evidence based on randomized controlled trials (RCTs). METHOD: A literature search was performed using PubMed, MEDLINE, and the Cochrane Library, using a PRISMA flowchart...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28560741/method-development-for-the-determination-of-elements-in-hypericum-perforatum-l-st-john-s-wort-herb-and-preparations-using-inductively-coupled-plasma-optical-emission-spectroscopy-and-microwave-digestion
#6
Jade D Owen, Sara J Evans, Amira Guirguis, Kathryn Kellett, Jacqueline L Stair
OBJECTIVES: A method was developed to analyze St John's wort (Hypericum perforatum L.) herb and preparations using inductively coupled plasma-optical emission spectroscopy (ICP-OES) to determine the quantity of 11 elements (Al, B, Ba, Ca, Cu, Fe, Mg, Mn, Ni, Sr and Zn). METHODS: This study includes the evaluation of digestion acids and calibration methods, as well as instrumental parameters such as choice of nebulizer and emission wavelength. KEY FINDINGS: Two nebulizers (Conikal and SeaSpray) performed similarly for most elements, and two optimum wavelengths were determined for each element...
May 31, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28542667/-ign-complementary-alternative-medicine-in-adolescents-with-attention-deficit-hyperactivity-disorder-and-mood-disorders
#7
María Pilar Pérez Carmona
The Complementary/Alternative Medicine (CAM) have been increasingly used by patients such as children and adolescents. The Ministry of Health in Chile (MINSAL) has recognized and regulated some CAM, although there is still unknown their effectiveness and safety of these. OBJECTIVE: Review the available evidence regarding the use of CAM in adolescents with the attention deficit hyperactivity syndrome (ADHD) and mood disorders. METHODOLOGY: A review of the related literature about this topic on PubMed, focus on the last 10 years and using as a keywords Complementary/Alternative Medicine/Therapies, Attention deficit disorder with hyperactivity, Mood disorders, and Children/Adolescents...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28502251/st-john-s-wort-hypericum-perforatum-induced-psychosis-a-case-report
#8
Maria Ferrara, Francesco Mungai, Fabrizio Starace
BACKGROUND: St John's wort (Hypericum perforatum) has been known for centuries for its therapeutic properties and its efficacy as an antidepressant has been confirmed by a growing body of evidence. During the last two decades it has also come to prominence with a wider public, due to advertising efforts across Europe and United States of America. However, its availability without prescription, as an over-the-counter medication, raises some concern regarding its clinical management and unsupervised administration to individuals with psychopathological risks...
May 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28472287/optimized-and-validated-hplc-analysis-of-st-john-s-wort-extract-and-final-products-by-simultaneous-determination-of-major-ingredients
#9
Konstantina Zeliou, Nikos I Kontaxis, Evangelia Margianni, Christos Petrou, Fotini N Lamari
Aim of this work was to develop a validated high performance liquid chromatography method for the analysis of extracts and final products of St. John's wort, according to international guidelines for bioanalytical method validation. Chromatographic separation was performed on a C18 column with a combination of gradient and isocratic steps; the mobile phase composed of ammonium acetate solution (pH 4.5; 10 mM), acetonitrile and methanol. Quantification and method validation was performed using extract spiked with external reference standards of chlorogenic acid, rutin, hyperoside, isoquercitrin, quercetin and hypericin...
May 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28465563/comparative-authentication-of-hypericum-perforatum-herbal-products-using-dna-metabarcoding-tlc-and-hplc-ms
#10
Ancuta Cristina Raclariu, Ramona Paltinean, Laurian Vlase, Aurélie Labarre, Vincent Manzanilla, Mihael Cristin Ichim, Gianina Crisan, Anne Krag Brysting, Hugo de Boer
Many herbal products have a long history of use, but there are increasing concerns over product efficacy, safety and quality in the wake of recent cases exposing discrepancies between labeling and constituents. When it comes to St. John's wort (Hypericum perforatum L.) herbal products, there is limited oversight, frequent off-label use and insufficient monitoring of adverse drug reactions. In this study, we use amplicon metabarcoding (AMB) to authenticate 78 H. perforatum herbal products and evaluate its ability to detect substitution compared to standard methods using thin-layer chromatography (TLC) and high performance liquid chromatography coupled with mass spectrometry (HPLC-MS)...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28454189/assessment-of-the-authenticity-of-herbal-dietary-supplements-comparison-of-chemical-and-dna-barcoding-methods
#11
Rahul S Pawar, Sara M Handy, Raymond Cheng, Nicole Shyong, Erich Grundel
About 7 % of the U. S. population reports using botanical dietary supplements. Increased use of such supplements has led to discussions related to their authenticity and quality. Reports of adulteration with substandard materials or pharmaceuticals are of concern because such substitutions, whether inadvertent or deliberate, may reduce the efficacy of specific botanicals or lead to adverse events. Methods for verifying the identity of botanicals include macroscopic and microscopic examinations, chemical analysis, and DNA-based methods including DNA barcoding...
April 28, 2017: Planta Medica
https://www.readbyqxmd.com/read/28450246/hypericum-perforatum-incorporated-chitosan-films-as-potential-bioactive-wound-dressing-material
#12
Seda Güneş, Funda Tıhmınlıoğlu
Recent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25-1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films...
September 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28445039/tricyclic-polyprenylated-acylphloroglucinols-from-st-john-s-wort-hypericum-perforatum
#13
Yi Guo, Na Zhang, Chunmei Chen, Jinfeng Huang, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Qingyi Tong, Jinwen Zhang, Zengwei Luo, Yongbo Xue, Yonghui Zhang
The new polyprenylated acylphloroglucinol derivatives 1-15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh2(OCOCF3)4-induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicyclo[3.3.1]nonane core...
April 26, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28444161/odor-perception-by-dogs-evaluating-two-training-approaches-for-odor-learning-of-sniffer-dogs
#14
Carola Fischer-Tenhagen, Dorothea Johnen, Wolfgang Heuwieser, Roland Becker, Kristin Schallschmidt, Irene Nehls
In this study, a standardized experimental set-up with various combinations of herbs as odor sources was designed. Two training approaches for sniffer dogs were compared; first, training with a pure reference odor, and second, training with a variety of odor mixtures with the target odor as a common denominator. The ability of the dogs to identify the target odor in a new context was tested. Six different herbs (basil, St. John's wort, dandelion, marjoram, parsley, ribwort) were chosen to produce reference materials in various mixtures with (positive) and without (negative) chamomile as the target odor source...
June 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28414068/modulation-of-anthraquinones-and-phloroglucinols-biosynthesis-in-hypericum-spp-by-cryogenic-treatment
#15
Katarína Bruňáková, Eva Čellárová
Beside the high post-cryogenic recovery rate, a reinstated scale of secondary metabolites in recovered plant tissues represents another inevitable aspect of an effective cryopreservation protocol for medicinal plants. The current study was aimed at evaluation of the elicitation potential of cryogenic treatment on secondary metabolism of some Hypericum species. In agreement with our assumption, the cold stimuli applied during the pre-cryogenic phase increased the tolerance to low temperatures (-196°C) in H...
April 13, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28377273/biotechnological-production-of-hyperforin-for-pharmaceutical-formulation
#16
REVIEW
Mariam Gaid, Eline Biedermann, Jendrik Füller, Paul Haas, Sönke Behrends, Rainer Krull, Stephan Scholl, Ute Wittstock, Christel Müller-Goymann, Ludger Beerhues
Hyperforin is a major active constituent of Hypericum perforatum (St. John's wort). It has amazing pharmacological activities, such as antidepressant properties, but it is labile and difficult to synthesize. Its sensitivity and lipophilicity are challenges for processing and formulation. Its chemical complexity provokes approaches of biotechnological production and modification. Dedifferentiated H. perforatum cell cultures lack appropriate storage sites and hence appreciable hyperforin levels. Shoot cultures are capable of forming hyperforin but less suitable for biomass up-scaling in bioreactors...
April 2, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28293192/indole-alkaloids-from-plants-as-potential-leads-for-antidepressant-drugs-a-mini-review
#17
Hazrulrizawati A Hamid, Aizi N M Ramli, Mashitah M Yusoff
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28279159/changes-in-prevalence-of-psychotropic-drug-use-and-alcohol-consumption-among-the-elderly-in-germany-results-of-two-national-health-interview-and-examination-surveys-1997-99-and-2008-11
#18
Ingrid-Katharina Wolf, Yong Du, Hildtraud Knopf
BACKGROUND: Psychotropic drug use and alcohol consumption among older adults need to be monitored over time as their use or combined use bears risks of harms. Representative data on changes in prevalence, patterns and co-relates of substance use are lacking in Germany. METHODS: Participants were older adults (60-79 years) from two German National Health Surveys: 1997-99 (GNHIES98, N = 1,606) and 2008-11 (DEGS1, N = 2,501). Included were drugs acting on the nervous system used during the last 7 days...
March 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28266019/quality-control-of-hypericum-perforatum-l-analytical-challenges-and-recent-progress
#19
REVIEW
Anastasia Agapouda, Anthony Booker, Tivadar Kiss, Judit Hohmann, Michael Heinrich, Dezső Csupor
OBJECTIVES: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches. KEY FINDINGS: Biologically active components of H. perforatum are chemically diverse; therefore, different chromatographic and detection methods are required for the comprehensive analysis of St. John's wort extracts. Naphthodianthrones, phloroglucinols and flavonoids are the most widely analysed metabolites of this plant...
March 7, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28216196/hypericum-perforatum-st-john-s-wort-beyond-depression-a-therapeutic-perspective-for-pain-conditions
#20
REVIEW
Nicoletta Galeotti
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae), popularly called St. John's wort (SJW), has a rich historical background being one of the oldest used and most extensively investigated medicinal herbs. Many bioactivities and applications of SJW are listed in popular and in scientific literature, including antibacterial, antiviral, anti-inflammatory. In the last three decades many studies focused on the antidepressant activity of SJW extracts. However, several studies in recent years also described the antinociceptive and analgesic properties of SJW that validate the traditional uses of the plant in pain conditions...
March 22, 2017: Journal of Ethnopharmacology
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