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St. John wort

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https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#1
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27864112/polar-extracts-from-the-berry-like-fruits-of-hypericum-androsaemum-l-as-a-promising-ingredient-in-skin-care-formulations
#2
Fabiana Antognoni, Mariacaterina Lianza, Ferruccio Poli, Michela Buccioni, Claudia Santinelli, Giovanni Caprioli, Romilde Iannarelli, Giulio Lupidi, Elisabetta Damiani, Daniela Beghelli, Alessia Alunno, Filippo Maggi
ETHNOPHARMACOLOGICAL RELEVANCE: The top flowering aerial parts of the Hypericum species are traditionally used to prepare ointments to heal cuts and burns. Sometimes even the fruits are used for these purposes. Hypericum androsaemum L., commonly known as tutsan or shrubby St. John's Wort, is a Mediterranean medicinal plant which has been traditionally used to prepare an ointment for treating cuts and wounds. AIM OF THE STUDY: To evaluate the extracts obtained from H...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27780755/st-john-s-wort-extract-and-hyperforin-inhibit-multiple-phosphorylation-steps-of-cytokine-signaling-and-prevent-inflammatory-and-apoptotic-gene-induction-in-pancreatic-%C3%AE-cells
#3
Michela Novelli, Marta Menegazzi, Pascale Beffy, Svetlana Porozov, Alex Gregorelli, Daniela Giacopelli, Vincenzo De Tata, Pellegrino Masiello
The extract of the herbaceous plant St. John's wort (SJW) and its phloroglucinol component hyperforin (HPF) were previously shown to inhibit cytokine-induced STAT-1 and NF-κB activation and prevent damage in pancreatic β cells. To further clarify the mechanisms underlying their protective effects, we evaluated the phosphorylation state of various factors of cytokine signaling pathways and the expression of target genes involved in β-cell function, inflammatory response and apoptosis induction. In the INS-1E β-cell line, exposed to a cytokine mixture with/without SJW extract (2-5μg/ml) or HPF (1-5μM), protein phosphorylation was assessed by western blotting and expression of target genes by real-time quantitative PCR...
October 22, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27688309/st-john-s-wort-potentiates-anti-nociceptive-effects-of-morphine-in-mice-models-of-neuropathic-pain
#4
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
OBJECTIVE:  In this study, we compared the efficacy of a combination of PKC-blocker St. John's Wort (SJW) and morphine in mice with painful antiretroviral (2,3-dideoxycitidine [ddC]) and chemotherapic (oxaliplatin) neuropathy. METHODS:  Morphine (1 and 5 mg/Kg i.p.), SJW (1 and 5 mg/Kg o.s.), or their combination was administered by systemic injection, and antinociception was determined by using the hot and cold plate tests. RESULTS:  Here we demonstrate the ability of SJW to relieve neuropathic pain in mice neuropathic models and a potentiation of morphine antinociception in thermal pain...
September 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27589952/a-systematic-review-of-st-john-s-wort-for-major-depressive-disorder
#5
Eric A Apaydin, Alicia R Maher, Roberta Shanman, Marika S Booth, Jeremy N V Miles, Melony E Sorbero, Susanne Hempel
BACKGROUND: This systematic review evaluated St. John's wort (SJW) for the treatment of Major Depressive Disorder (MDD). The objectives of this review are to (1) evaluate the efficacy and safety of SJW in adults with MDD compared to placebo and active comparator and (2) evaluate whether the effects vary by severity of MDD. METHODS: We searched PubMed, CINAHL, PsycINFO, CENTRAL, Embase, AMED, MANTIS, Web of Science, and ICTRP and existing reviews to November 2014...
September 2, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27583423/complementary-integrative-therapies-that-work-a-review-of-the-evidence
#6
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27516347/caco-2-cells-expression-regulation-and-function-of-drug-transporters-compared-to-human-jejunal-tissue
#7
S Brueck, J Strohmeier, D Busch, M Drozdzik, S Oswald
BACKGROUND: Induction or inhibition of drug transporting proteins by concomitantly administered drugs can cause serious drug-drug interactions (DDIs). However, in vitro assays currently available are mostly for studying the inhibitory potential of drugs on intestinal transporter proteins, rather than induction. Therefore, in this study we investigated the suitability of the frequently used intestinal Caco-2 cell line to predict transporter-mediated DDIs as caused by induction via activation of nuclear receptors...
August 12, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27486153/canadian-network-for-mood-and-anxiety-treatments-canmat-2016-clinical-guidelines-for-the-management-of-adults-with-major-depressive-disorder-section-5-complementary-and-alternative-medicine-treatments
#8
Arun V Ravindran, Lynda G Balneaves, Guy Faulkner, Abigail Ortiz, Diane McIntosh, Rachel L Morehouse, Lakshmi Ravindran, Lakshmi N Yatham, Sidney H Kennedy, Raymond W Lam, Glenda M MacQueen, Roumen V Milev, Sagar V Parikh
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses...
September 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27470545/review-on-mechanisms-and-interactions-in-concomitant-use-of-herbs-and-warfarin-therapy
#9
Paula Mendonça Leite, Maria Auxiliadora Parreiras Martins, Rachel Oliveira Castilho
The effectiveness of warfarin, an oral anticoagulant originally derived from a plant, is strongly affected by patient's characteristics such as the age, presence of comorbidities, and concomitant use of another drug. Warfarin has the potential to interact with many drugs, medicinal plants, and food, which increases the risk of adverse events. A critical analysis of scientific literature was conducted to assess the interferences of medicinal plants with blood haemostasis and then with warfarin anticoagulation...
June 17, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27468236/a-meta-analysis-on-the-efficacy-and-safety-of-st-john-s-wort-extract-in-depression-therapy-in-comparison-with-selective-serotonin-reuptake-inhibitors-in-adults
#10
Yong-Hua Cui, Yi Zheng
OBJECTIVE: The aim of the study was to investigate the efficacy and safety of St John's wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. METHODS: Databases were searched for studies comparing efficacy and/or safety of St John's wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis. RESULTS: Twenty-seven studies met the study entry criteria...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27467225/celery-root-extract-as-an-inducer-of-mania-induction-in-a-patient-on-venlafaxine-and-st-john-s-wort
#11
Zaira Khalid, Ferdnand C Osuagwu, Bilal Shah, Nikita Roy, James E Dillon, Ronald Bradley
Celery root belongs to a group of plants classified as the umbelliferous family, which contains phytoestrogens. Phytoestrogens are structurally similar to estrogen as they share a pair of hydroxyl groups and phenolic ring, which enables them to bind to estrogen receptors directly, making them a herbal remedy for low estrogen states such as menopause. We present a case of a female patient with depression who was stabilized on venlafaxine and St John's Wort, and who developed a manic episode due to elevated serum venlafaxine levels after she started taking celery extracts for menopausal related issues...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27467196/u-s-medical-eligibility-criteria-for-contraceptive-use-2016
#12
Kathryn M Curtis, Naomi K Tepper, Tara C Jatlaoui, Erin Berry-Bibee, Leah G Horton, Lauren B Zapata, Katharine B Simmons, H Pamela Pagano, Denise J Jamieson, Maura K Whiteman
The 2016 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC) comprises recommendations for the use of specific contraceptive methods by women and men who have certain characteristics or medical conditions. These recommendations for health care providers were updated by CDC after review of the scientific evidence and consultation with national experts who met in Atlanta, Georgia, during August 26-28, 2015. The information in this report updates the 2010 U.S. MEC (CDC. U.S. medical eligibility criteria for contraceptive use, 2010...
2016: MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports
https://www.readbyqxmd.com/read/27462333/neuroprotective-activity-of-hypericum-perforatum-and-its-major-components
#13
REVIEW
Ana I Oliveira, Cláudia Pinho, Bruno Sarmento, Alberto C P Dias
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. John's wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27454708/estrogenic-activity-of-hyperforin-in-mcf-7-human-breast-cancer-cells-transfected-with-estrogen-receptor
#14
Joseph Kwon, Kyung Seo Oh, Se-Young Cho, Mi Ae Bang, Hwan Seon Kim, Bipin Vaidya, Duwoon Kim
Hyperforin, a major active compound of St. John's wort extract, affects estrogenic activity. In this study, the compound evoked estrogen response element-dependent luciferase activity and cell proliferation in MCF-7 cells. Hyperforin-induced cell proliferation was significantly inhibited by the estrogen receptor antagonist ICI 182,780. These results suggested that hyperforin had estrogenic and cell proliferation activities, which were stimulated via the estrogen receptor. Compared to 17β-estradiol, hyperforin showed significantly lower estrogenic activity and cell proliferation...
July 25, 2016: Planta Medica
https://www.readbyqxmd.com/read/27446112/a-perspective-on-hypericum-perforatum-genetic-transformation
#15
REVIEW
Weina Hou, Preeti Shakya, Gregory Franklin
Hypericum perforatum (St John's wort) is a reservoir of diverse classes of biologically active and high value secondary metabolites, which captured the interest of both researchers and the pharmaceutical industry alike. Several studies and clinical trials have shown that H. perforatum extracts possess an astounding array of pharmacological properties. These properties include antidepressant, anti-inflammatory, antiviral, anti-cancer, and antibacterial activities; and are largely attributed to the naphtodianthrones and xanthones found in the genus...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27444983/co-administration-of-st-john-s-wort-and-hormonal-contraceptives-a-systematic-review
#16
Erin N Berry-Bibee, Myong-Jin Kim, Naomi K Tepper, Halley E M Riley, Kathryn M Curtis
OBJECTIVES: St. John's wort (SJW) is a known strong inducer of the cytochrome P450 (CYP) 3 A4 enzyme, and both the ethinyl estradiol and progestin components of hormonal contraceptives are substrates of CYP3A4. This systematic review examined whether the co-administration of SJW and hormonal contraceptives leads to significant safety or efficacy concerns. STUDY DESIGN: Systematic review. METHODS: PubMed and Cochrane Library databases were searched for articles of any comparative study design (clinical or pharmacokinetic) that examined potential interactions between SJW and hormonal contraceptives in women of reproductive age...
July 18, 2016: Contraception
https://www.readbyqxmd.com/read/27421270/new-pharmacological-agents-to-aid-smoking-cessation-and-tobacco-harm-reduction-what-has-been-investigated-and-what-is-in-the-pipeline
#17
REVIEW
Emma Beard, Lion Shahab, Damian M Cummings, Susan Michie, Robert West
A wide range of support is available to help smokers to quit and to aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications with (1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and (2) 24 alternative products: cytisine (novel outside Central and Eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e...
October 2016: CNS Drugs
https://www.readbyqxmd.com/read/27343017/st-john-s-wort-versus-counterfeit-st-john-s-wort-an-hptlc-study
#18
Débora A Frommenwiler, Eike Reich, Sidney Sudberg, Maged H M Sharaf, Anton Bzhelyansky, Ben Lucas
Hypericum perforatum L. is the most commonly used herb for treating depression. Due to the popularity of this botanical, there is a potential for economically driven adulteration of St. John's wort (SJW) products. The goal of this study was to investigate SJW ingredients suspected to be adulterated based on simple preliminary HPTLC tests. Commercial samples were analyzed by HPTLC following the United States Pharmacopeia (USP) monograph methodology, with additional visualization under white light. A number of these samples presented odd methanolic solution colors and unconventional HPTLC fingerprints, suggesting the presence of other species and/or extraneous polar additives...
September 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27340114/warfarin-st-john-s-wort-and-inr
#19
COMMENT
Angela Cattanach, Siboniso Sibindi
No abstract text is available yet for this article.
April 2016: Australian Prescriber
https://www.readbyqxmd.com/read/27316629/oral-antineoplastic-agent-interactions-with-medicinal-plants-and-food-an-issue-to-take-into-account
#20
REVIEW
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Rosa Romero-Jiménez, Irene Iglesias-Peinado, Ana Herranz-Alonso, María Sanjurjo-Sáez
OBJECTIVE: To review interactions between oral antineoplastic agents (OAAs) for the treatment of solid and hematological tumors and common food and medicinal plants. MATERIALS AND METHODS: All potential interactions between OAAs, medicinal plants and food were reviewed. OAAs were considered to be drugs for oral administration that have direct antitumor activity and were approved by the European Medicines Agency in April 2015. We performed the literature search in Pubmed(®) considering only medicinal plants and food...
November 2016: Journal of Cancer Research and Clinical Oncology
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