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St. John wort

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https://www.readbyqxmd.com/read/28064110/clinical-use-of-hypericum-perforatum-st-john-s-wort-in-depression-a-meta-analysis
#1
REVIEW
Qin Xiang Ng, Nandini Venkatanarayanan, Collin Yih Xian Ho
INTRODUCTION: St John's wort is a popular herbal remedy recommended by Traditional Chinese Medicine (TCM) practitioners and licensed and widely prescribed for depression in many European countries. However, conflicting data regarding its benefits and risks exist, and the last large meta-analysis on St John's wort use for depression was done in 2008, with no updated meta-analysis available. METHODS: Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016...
January 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28063268/evaluation-of-the-quality-of-herbal-teas-by-dart-tof-ms
#2
Jana Prchalová, František Kovařík, Aleš Rajchl
The paper focuses on the optimization, settings and validation of direct analysis in real time (DART) coupled with time of flight detector (TOF) when used for the evaluation of the quality of selected herbal teas (fennel, chamomile, nettle, linden, peppermint, thyme, lemon balm, marigold, sage, rose hip, St. John's Wort). The ionization mode, the optimal ionization temperature and the type of solvent for sample extraction were optimized. The characteristic compounds of the analysed herbal teas (glycosides, flavonoids, phenolic and terpenic substances, such as chamazulene, anethole, menthol, thymol, salviol, hypericin etc...
January 7, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28052331/computed-regioselectivity-and-conjectured-biological-activity-of-ene-reactions-of-singlet-oxygen-with-the-prenylnatural-product-hyperforin
#3
Inna Abramova, Benjamin Rudshteyn, Joel F Liebman, Alexander Greer
Hyperforin is a constituent of St. John's wort and coexists with the singlet oxygen sensitizer hypericin. Density functional theory, molecular mechanics and Connolly surface calculations show that accessibility in the singlet oxygen 'ene' reaction favors the hyperforin "southwest" and "southeast" prenyl (2-methyl-2-butenyl) groups over the northern prenyl groups. While the southern part of hyperforin is initially more susceptible to oxidation, up to 4 'ene' reactions of singlet oxygen can take place. Computational results assist in predicting the fate of adjacent hydroperoxides in hyperforin, where the loss of hydrogen atoms may lead to the formation of a hydrotrioxide and a carbonyl instead of a Russell reaction...
January 4, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28040120/a-mixture-of-st-john-s-wort-and-sea-buckthorn-oils-regresses-endometriotic-implants-and-affects-the-levels-of-inflammatory-mediators-in-peritoneal-fluid-of-the-rat-a-surgically-induced-endometriosis-model
#4
Mert İlhan, İpek Süntar, Mürşide Ayşe Demirel, Erdem Yeşilada, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVE: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oil) in the treatment of endometriosis. MATERIALS AND METHODS: The activity was assessed in surgically induced endometriosis in rats...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28011162/effect-of-st-john-s-wort-hypericum-perforatum-oily-extract-for-the-care-and-treatment-of-pressure-sores-a-case-report
#5
Ali Yücel, Yüksel Kan, Erdem Yesilada, Onat Akın
ETHNOPHARMACOLOGICAL RELEVANCE: Topical formulations such as oily extracts or ointments prepared with the flowering aerial parts of St. John's wort (Hypericum perforatum L., Hypericaceae) have been used in the management of a wide range dermatological problems including superficial wounds and burns, bruises, contusions and many others in the worldwide traditional medicines. AIM OF THE STUDY: This is the first case study reporting the beneficial effects of an oily extract of St...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28007487/effects-of-hypericum-perforatum-on-the-healing-of-xenografts-a-histomorphometric-study-in-rabbits
#6
I Damlar, O F Arpağ, U Tatli, A Altan
The aim of this study was to investigate effects of the Hypericum perforatum (St John's Wort) on bone healing in rabbit calvarium. Ten male New Zealand rabbits each had three bicortical defects made in the calvarial bones, which were filled with xenograft, xenograft+H perforatum oil extract, and autogenous graft. Four weeks postoperatively all rabbits were killed and the bony defects examined histomorphometrically. Tissue compartments including new bone (p<0.001), marrow space (p<0.001), and residual bone grafts (p=0...
December 19, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27999964/arbuscular-mycorrhizal-fungi-altered-the-hypericin-pseudohypericin-and-hyperforin-content-in-flowers-of-hypericum-perforatum-grown-under-contrasting-p-availability-in-a-highly-organic-substrate
#7
Silvia Lazzara, Marcello Militello, Alessandra Carrubba, Edoardo Napoli, Sergio Saia
St. John's Wort (Hypericum perforatum) is a perennial herb able to produce water-soluble active ingredients (a.i.), mostly in flowers, with a wide range of medicinal and biotechnological uses. However, information about the ability of arbuscular mycorrhizal fungi (AMF) to affect its biomass accumulation, flower production, and concentration of a.i. under contrasting nutrient availability is still scarce. In the present experiment, we evaluated the role of AMF on growth, flower production, and concentration of bioactive secondary metabolites (hypericin, pseudohypericin, and hyperforin) of H...
December 20, 2016: Mycorrhiza
https://www.readbyqxmd.com/read/27989965/st-john-s-wort-extract-and-hyperforin-inhibit-multiple-phosphorylation-steps-of-cytokine-signaling-and-prevent-inflammatory-and-apoptotic-gene-induction-in-pancreatic-%C3%AE-cells
#8
Michela Novelli, Marta Menegazzi, Pascale Beffy, Svetlana Porozov, Alex Gregorelli, Daniela Giacopelli, Vincenzo De Tata, Pellegrino Masiello
The extract of the herbaceous plant St. John's wort (SJW) and its phloroglucinol component hyperforin (HPF) were previously shown to inhibit cytokine-induced STAT-1 and NF-κB activation and prevent damage in pancreatic β cells. To further clarify the mechanisms underlying their protective effects, we evaluated the phosphorylation state of various factors of cytokine signaling pathways and the expression of target genes involved in β-cell function, inflammatory response and apoptosis induction. In the INS-1E β-cell line, exposed to a cytokine mixture with/without SJW extract (2-5μg/ml) or HPF (1-5μM), protein phosphorylation was assessed by Western blotting and expression of target genes by real-time quantitative PCR...
October 22, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27976229/adulteration-of-st-john-s-wort-products-how-to-identify-quality-problems
#9
D A Frommenwiler, S Sudberg, Mhm Sharaf, A Bzhelyansky, B Lucas, E Reich
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976079/in-vitro-cytoprotective-anti-inflammatory-effects-of-stw-3-vi-st-john-s-wort
#10
A Schwendler, H Abdel-Aziz, J Hüther, G A Bonaterra, A Cordes, R Kinscherf
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975976/chemically-engineered-extracts-of-st-john-s-wort-as-sources-of-polyprenylated-acylphloroglucinols-to-prevent-endothelial-dysfunction
#11
M Le Bot, N Corlay, A Michaud, S Pagie, P Richomme, B Charreau, S Derbré
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#12
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27864112/polar-extracts-from-the-berry-like-fruits-of-hypericum-androsaemum-l-as-a-promising-ingredient-in-skin-care-formulations
#13
Fabiana Antognoni, Mariacaterina Lianza, Ferruccio Poli, Michela Buccioni, Claudia Santinelli, Giovanni Caprioli, Romilde Iannarelli, Giulio Lupidi, Elisabetta Damiani, Daniela Beghelli, Alessia Alunno, Filippo Maggi
ETHNOPHARMACOLOGICAL RELEVANCE: The top flowering aerial parts of the Hypericum species are traditionally used to prepare ointments to heal cuts and burns. Sometimes even the fruits are used for these purposes. Hypericum androsaemum L., commonly known as tutsan or shrubby St. John's Wort, is a Mediterranean medicinal plant which has been traditionally used to prepare an ointment for treating cuts and wounds. AIM OF THE STUDY: To evaluate the extracts obtained from H...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27780755/st-john-s-wort-extract-and-hyperforin-inhibit-multiple-phosphorylation-steps-of-cytokine-signaling-and-prevent-inflammatory-and-apoptotic-gene-induction-in-pancreatic-%C3%AE-cells
#14
Michela Novelli, Marta Menegazzi, Pascale Beffy, Svetlana Porozov, Alex Gregorelli, Daniela Giacopelli, Vincenzo De Tata, Pellegrino Masiello
The extract of the herbaceous plant St. John's wort (SJW) and its phloroglucinol component hyperforin (HPF) were previously shown to inhibit cytokine-induced STAT-1 and NF-κB activation and prevent damage in pancreatic β cells. To further clarify the mechanisms underlying their protective effects, we evaluated the phosphorylation state of various factors of cytokine signaling pathways and the expression of target genes involved in β-cell function, inflammatory response and apoptosis induction. In the INS-1E β-cell line, exposed to a cytokine mixture with/without SJW extract (2-5μg/ml) or HPF (1-5μM), protein phosphorylation was assessed by western blotting and expression of target genes by real-time quantitative PCR...
December 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27688309/st-john-s-wort-potentiates-anti-nociceptive-effects-of-morphine-in-mice-models-of-neuropathic-pain
#15
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
OBJECTIVE:  In this study, we compared the efficacy of a combination of PKC-blocker St. John's Wort (SJW) and morphine in mice with painful antiretroviral (2,3-dideoxycitidine [ddC]) and chemotherapic (oxaliplatin) neuropathy. METHODS:  Morphine (1 and 5 mg/Kg i.p.), SJW (1 and 5 mg/Kg o.s.), or their combination was administered by systemic injection, and antinociception was determined by using the hot and cold plate tests. RESULTS:  Here we demonstrate the ability of SJW to relieve neuropathic pain in mice neuropathic models and a potentiation of morphine antinociception in thermal pain...
September 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27589952/a-systematic-review-of-st-john-s-wort-for-major-depressive-disorder
#16
Eric A Apaydin, Alicia R Maher, Roberta Shanman, Marika S Booth, Jeremy N V Miles, Melony E Sorbero, Susanne Hempel
BACKGROUND: This systematic review evaluated St. John's wort (SJW) for the treatment of Major Depressive Disorder (MDD). The objectives of this review are to (1) evaluate the efficacy and safety of SJW in adults with MDD compared to placebo and active comparator and (2) evaluate whether the effects vary by severity of MDD. METHODS: We searched PubMed, CINAHL, PsycINFO, CENTRAL, Embase, AMED, MANTIS, Web of Science, and ICTRP and existing reviews to November 2014...
September 2, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27583423/complementary-integrative-therapies-that-work-a-review-of-the-evidence
#17
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27516347/caco-2-cells-expression-regulation-and-function-of-drug-transporters-compared-to-human-jejunal-tissue
#18
S Brueck, J Strohmeier, D Busch, M Drozdzik, S Oswald
BACKGROUND: Induction or inhibition of drug transporting proteins by concomitantly administered drugs can cause serious drug-drug interactions (DDIs). However, in vitro assays currently available are mostly for studying the inhibitory potential of drugs on intestinal transporter proteins, rather than induction. Therefore, in this study we investigated the suitability of the frequently used intestinal Caco-2 cell line to predict transporter-mediated DDIs as caused by induction via activation of nuclear receptors...
August 12, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27486153/canadian-network-for-mood-and-anxiety-treatments-canmat-2016-clinical-guidelines-for-the-management-of-adults-with-major-depressive-disorder-section-5-complementary-and-alternative-medicine-treatments
#19
Arun V Ravindran, Lynda G Balneaves, Guy Faulkner, Abigail Ortiz, Diane McIntosh, Rachel L Morehouse, Lakshmi Ravindran, Lakshmi N Yatham, Sidney H Kennedy, Raymond W Lam, Glenda M MacQueen, Roumen V Milev, Sagar V Parikh
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses...
September 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27470545/review-on-mechanisms-and-interactions-in-concomitant-use-of-herbs-and-warfarin-therapy
#20
REVIEW
Paula Mendonça Leite, Maria Auxiliadora Parreiras Martins, Rachel Oliveira Castilho
The effectiveness of warfarin, an oral anticoagulant originally derived from a plant, is strongly affected by patient's characteristics such as the age, presence of comorbidities, and concomitant use of another drug. Warfarin has the potential to interact with many drugs, medicinal plants, and food, which increases the risk of adverse events. A critical analysis of scientific literature was conducted to assess the interferences of medicinal plants with blood haemostasis and then with warfarin anticoagulation...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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