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https://www.readbyqxmd.com/read/28339671/characteristics-of-donor-specific-anti-hla-antibodies-and-outcome-in-renal-transplant-patients-treated-with-a-standardized-induction-regimen
#1
Daniel Zecher, Christian Bach, Christoph Staudner, Carsten A Böger, Tobias Bergler, Bernhard Banas, Bernd M Spriewald
Background.: Pre-transplant donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) have been associated with antibody-mediated rejection (AMR) and early kidney allograft loss. Uncertainties remain regarding the general applicability of these findings and the optimal induction therapy in DSA-positive patients. Methods.: Pre-transplant sera from 174 patients receiving a crossmatch-negative kidney transplant were retrospectively analysed for DSA using Luminex technology...
February 18, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28335030/urinary-kinetics-of-heroin-metabolites-in-pigs-shortly-after-intake
#2
Gudrun Høiseth, André Gottås, Thomas Berg, Marianne Arnestad, Per Steinar Halvorsen, Liliana C Bachs
In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin metabolites (morphine, 6-monoacetylmorphine (6-MAM) and morphine-3-glucuronide (M3G)) every 30 min until 330 min after injection of a 20 mg heroin dose in six pigs. Samples were analyzed using a previously published, fully validated liquid chromatography-tandem mass spectrometry method...
February 27, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28333952/adjuvant-treatment-with-the-bacterial-lysate-om-85-improves-management-of-atopic-dermatitis-a-randomized-study
#3
Christine Bodemer, Gerard Guillet, Frederic Cambazard, Franck Boralevi, Stefania Ballarini, Christian Milliet, Paola Bertuccio, Carlo La Vecchia, Jean-François Bach, Yves de Prost
BACKGROUND: Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. OBJECTIVE: This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children...
2017: PloS One
https://www.readbyqxmd.com/read/28333761/race-ethnicity-health-insurance-and-mortality-in-older-survivors-of-critical-illness
#4
Matthew R Baldwin, Jessica L Sell, Nina Heyden, Azka Javaid, David A Berlin, Wendy C Gonzalez, Peter B Bach, Mathew S Maurer, Gina S Lovasi, David J Lederer
OBJECTIVES: To determine whether minority race or ethnicity is associated with mortality and mediated by health insurance coverage among older (≥ 65 yr old) survivors of critical illness. DESIGN: A retrospective cohort study. SETTING: Two New York City academic medical centers. PATIENTS: A total of 1,947 consecutive white (1,107), black (361), and Hispanic (479) older adults who had their first medical-ICU admission from 2006 through 2009 and survived to hospital discharge...
March 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28326340/organ-and-tissue-level-properties-are-more-sensitive-to-age-than-osteocyte-lacunar-characteristics-in-rat-cortical-bone
#5
Nina Kølln Wittig, Fiona Linnea Bach-Gansmo, Mie Elholm Birkbak, Malene Laugesen, Annemarie Brüel, Jesper Skovhus Thomsen, Henrik Birkedal
Modeling and remodeling induce significant changes of bone structure and mechanical properties with age. Therefore, it is important to gain knowledge of the processes taking place in bone over time. The rat is a widely used animal model, where much data has been accumulated on age-related changes of bone on the organ and tissue level, whereas features on the nano- and micrometer scale are much less explored. We investigated the age-related development of organ and tissue level bone properties such as bone volume, bone mineral density, and load to fracture and correlated these with osteocyte lacunar properties in rat cortical bone...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28325273/length-of-time-between-surgery-and-return-to-sport-after-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers-does-not-predict-need-for-revision-surgery
#6
Brandon J Erickson, Peter N Chalmers, Bernard R Bach, Joshua S Dines, Nikhil N Verma, Charles A Bush-Joseph, Steven B Cohen, Anthony A Romeo
HYPOTHESIS: Pitchers who return to sport (RTS) sooner will have a higher risk of revision ulnar collateral ligament reconstruction (UCLR) than those who return later. METHODS: All professional (major and minor league) baseball pitchers who underwent UCLR between 1974 and 2016 were identified. Date of the index UCLR was recorded. The date of the first game back at any professional level after surgery and the date the pitcher returned to the same level of play (if applicable) were recorded...
April 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28324606/sample-preparation-and-choice-of-fluorophores-for-single-and-dual-color-photo-activated-localization-microscopy-palm-with-bacterial-cells
#7
Juri N Bach, Giacomo Giacomelli, Marc Bramkamp
Photo-activated localization microscopy (PALM) is one of the light microscopy techniques providing highest resolution. Single photo-activatable or photo-switchable fluorescent molecules are stochastically excited. The point spread function of this event is recorded and the exact fluorophore position is calculated. This chapter describes how bacterial samples can be prepared for PALM to achieve routinely a resolution of ≤30 nm using fluorophores such as mNeonGreen, Dendra2, and PAmCherry. It is also explained how to perform multicolor PALM and combine it with total internal reflection (TIRF) microscopy to increase resolution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323628/effects-of-bach-flower-remedies-on-menopausal-symptoms-and-sleep-pattern-a-case-report
#8
Marcele Siegler, Cristina Frange, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Context • During the postmenopausal stage, women go through many remarkable changes, including physical, emotional, and hormonal. They also experience some unwanted effects, such as vasomotor symptoms, anxiety, and insomnia. The use of Bach flower remedies has been described as a supporting therapy for those symptoms. Objectives • The investigation aimed to evaluate the effects of the supplement on sleep pattern (ie, sleep perception and objective sleep) and on menopausal symptoms. Design • The research team created a case report...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28319302/br%C3%A3-nsted-acid-catalysis-in-visible-light-induced-2-2-%C3%A2-photocycloaddition-reactions-of-enone-dithianes
#9
Christoph Brenninger, Alexander Pöthig, Thorsten Bach
1,3-Dithiane-protected enones (enone dithianes) were found to undergo an intramolecular [2+2] photocycloaddition under visible-light irradiation (λ=405 nm) in the presence of a Brønsted acid (7.5-10 mol %). Key to the success of the reaction is presumably the formation of colored thionium ions, which are intermediates of the catalytic cycle. Cyclobutanes were thus obtained in very good yields (78-90 %). It is also shown that the dithiane moiety can be reductively or oxidatively removed without affecting the photochemically constructed ring skeleton...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28319242/quality-of-cancer-surveillance-clinical-practice-guidelines-specificity-and-consistency-of-recommendations
#10
Ryan P Merkow, Deborah Korenstein, Rubaya Yeahia, Peter B Bach, Shrujal S Baxi
Importance: Primary care clinicians, who are increasingly responsible for caring for the growing population of cancer survivors, may be unfamiliar with appropriate cancer surveillance strategies. Clinical practice guidelines can inform cancer follow-up care and surveillance testing. Vague recommendations and inconsistencies among guidelines can lead to overuse and underuse of health care resources and have a negative impact on cost and quality of survivorship care. Objective: To examine the specificity and consistency of recommendations for surveillance after active treatment across cancer guidelines...
March 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28318911/cannabis-use-polysubstance-use-and-psychosis-spectrum-symptoms-in-a-community-based-sample-of-u-s-youth
#11
Jason D Jones, Monica E Calkins, J Cobb Scott, Emily C Bach, Raquel E Gur
PURPOSE: To examine how cannabis use and polysubstance use among cannabis users relate to psychosis spectrum (PS) symptoms in a large community-based sample of U.S. youth. METHODS: Four thousand one hundred seventy-one youths (aged 14-21 years; mean = 16.90 years, SD = 1.85; 55% female) from the Philadelphia Neurodevelopmental Cohort completed assessments of substance use, PS symptoms, and confounding variables (e.g., demographics, comorbid psychopathology, and trauma exposure)...
March 16, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28315133/remembering-navasard-v-karapetyan-1936-2015
#12
Nadezhda P Yurina, Vladimir O Popov, Alexander A Krasnovsky, Govindjee
Navasard Vaganovich Karapetyan (September 6, 1936-March 6, 2015) began his scientific career at the Bach Institute of Biochemistry of the Russian Academy of Sciences, Moscow, and was associated with this institute for over 56 years. He worked in the area of biochemistry and biophysics of photosynthesis and was especially known for his studies on chlorophyll a fluorescence in higher plants and cyanobacteria, molecular organization of Photosystem I, photoprotective energy dissipation, and dynamics of energy migration in the two photosystems...
March 17, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28303621/distal-skin-vasodilation-promotes-rapid-sleep-onset-in-preterm-neonates
#13
Lucile Barcat, Pauline Decima, Emilie Bodin, Stephane Delanaud, Erwan Stephan-Blanchard, Andre Leke, Jean-Pierre Libert, Pierre Tourneux, Veronique Bach
Although sleep is of paramount importance for preterm neonates, care of the latter in a neonatal intensive care unit does not favour sleep. Given that several studies in adults have described a 'vegetative preparedness to sleep' (in which distal skin vasodilation before lights-out promotes rapid sleep onset), we looked at whether or not this process operates in preterm neonates. Sleep propensity was assessed in terms of the duration of a spontaneous episode of wakefulness (W). Skin temperatures at six body sites (the abdomen, pectoral region, eye, hand, thigh and foot) were measured (using infrared thermography) during nocturnal polysomnography in 29 9-day-old preterm neonates (postmenstrual age: 209 ± 9 days)...
March 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28303363/test-retest-reliability-of-scotopic-full-field-electroretinograms-in-rabbits
#14
Jan Luebke, Alexandra Anton, Michael Bach
PURPOSE: To explore test-retest reliability of standard scotopic full-field ERG measurements in New Zealand White rabbits. The ERG is widely used for testing of retinal integrity after any ocular treatment. We here present detailed stimulus-response dependencies for single healthy and untreated animals, concentrating on test-retest reproducibility. MATERIALS AND METHODS: Five New Zealand White rabbits (aged 8-10 weeks, weight about 2.0-2.5 kg) underwent binocular ERG measurements after intramuscular anesthesia and pharmaceutical pupillary dilatation at a baseline day and 10 days later...
March 16, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28303338/blood-glucose-kinetics-and-physiological-changes-in-a-type-1-diabetic-finisher-of-the-ultraman-triathlon-a-case-study
#15
Christopher W Bach, Daniel A Baur, William S Hyder, Michael J Ormsbee
PURPOSE: To investigate the blood glucose kinetics and physiological effects experienced by a type 1 diabetic (T1D) finisher of a 3-day, multi-stage ultra endurance triathlon consisting of a 10 km swim and 144.8 km bike (stage 1), a 275.4 km bike (stage 2), and an 84.4 km run (stage 3). METHODS: The athlete self-monitored blood glucose (SMBG) levels via fingerstick blood draw and hand-held glucometer. Researchers evaluated blood glucose kinetics via a continuous glucose monitoring device...
March 16, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302366/the-cf-cares-primary-palliative-care-model-a-cf-specific-structured-assessment-of-symptoms-distress-and-coping
#16
Deborah Friedman, Rachel W Linnemann, Lily L Altstein, Suhayla Islam, Kieu-Tram Bach, Chelsea Lamb, John Volpe, Caitlin Doolittle, Anita St John, Patricia J O'Malley, Gregory S Sawicki, Anna M Georgiopoulos, Lael M Yonker, Samuel M Moskowitz
BACKGROUND: Current palliative care tools do not address distressing chronic symptoms that are most relevant to cystic fibrosis. METHODS: A CF-specific structured assessment based on a primary palliative care framework was administered to 41 adolescents and adults with CF. Descriptive and correlational analyses were conducted. RESULTS: Patients reported numerous physical and psychological symptoms (mean of 10 per patient), with psychological symptoms rated as more distressing...
March 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28301406/reply
#17
Sven R Andresen, Rikke M Hansen, Fin Biering-Sørensen, Ellen Merete Hagen, Andrew S C Rice, Flemming W Bach, Nanna B Finnerup
No abstract text is available yet for this article.
April 2017: Pain
https://www.readbyqxmd.com/read/28300384/quantitation-of-clinical-feedback-on-image-quality-differences-between-two-ct-scanner-models
#18
Steven T Bache, Paul J Stauduhar, Xinming Liu, Evelyne M Loyer, X John Rong
The aim of this work was to quantitate differences in image quality between two GE CT scanner models - the LightSpeed VCT ("VCT") and Discovery HD750 ("HD") - based upon feedback from radiologists at our institution. First, 3 yrs of daily QC images of the manufacturer-provided QC phantom from 10 scanners - five of each model - were analyzed for both noise magnitude, measured as CT-number standard deviation, and noise power spectrum within the uniform water section. The same phantom was then scanned on four of each model and analyzed for low contrast detectability (LCD) using a built-in LCD tool at the scanner console...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28298535/resistant-starch-but-not-enzymatically-modified-waxy-maize-delays-development-of-diabetes-in-zucker-diabetic-fatty-rats
#19
Mette Skou Hedemann, Kjeld Hermansen, Sven Pedersen, Knud Erik Bach Knudsen
Background: The incidence of type 2 diabetes (T2D) is increasing worldwide, and nutritional management of circulating glucose may be a strategic tool in the prevention of T2D.Objective: We studied whether enzymatically modified waxy maize with an increased degree of branching delayed the onset of diabetes in male Zucker diabetic fatty (ZDF) rats.Methods: Forty-eight male ZDF rats, aged 5 wk, were divided into 4 groups and fed experimental diets for 9 wk that contained 52.95% starch: gelatinized corn starch (S), glucidex (GLU), resistant starch (RS), or enzymatically modified starch (EMS)...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28294620/the-effect-of-antibiotics-and-diet-on-enterolactone-concentration-and-metabolome-studied-by-targeted-and-non-targeted-lc-ms-metabolomics
#20
Anne Katrine Bolvig, Natalja P Nørskov, Mette Skou Hedemann, Leslie Foldager, Brendan McCarthy-Sinclair, Maria L Marco, Helle N Lærke, Knud Erik Bach Knudsen
High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here, we investigate the link between antibiotic use and lignan metabolism in pigs using LC-MS/MS. The effect of lignan intake and antibiotic use on the gut microbial community and the pig metabolome is studied by 16S rRNA sequencing and non-targeted LC-MS...
March 15, 2017: Journal of Proteome Research
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