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https://www.readbyqxmd.com/read/29051265/regulation-of-notch-signaling-by-rab7-and-rab8-requires-carboxyl-methylation-by-icmt
#1
Helen Court, Ian M Ahearn, Marc Amoyel, Erika A Bach, Mark R Philips
Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of either ICMT or NOTCH1 accelerates pancreatic neoplasia in Pdx1-Cre;LSL-Kras(G12D) mice, suggesting that ICMT is required for NOTCH signaling. We used Drosophila melanogaster wing vein and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT (ste14 in flies). We identified Rab7 and Rab8 as ICMT substrates that when silenced phenocopy ste14 deficiency...
October 19, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29049218/cardiovascular-findings-on-computed-tomography-in-patients-with-unclear-finding-situation-and-trauma-of-unknown-origin
#2
Hans-Jonas Meyer, Dominik Schramm, Andreas Gunter Bach, Anne Beeskow, Alexey Surov
Incidental cardiovascular findings are common and can be found in up to 70% of patients. Previously, several reports about incidental findings (IFs) on whole body computed tomography (CT) were published. However, no previous study investigated cardiovascular IFs in patients with unclear finding situation and trauma of unknown origin on whole body CT.The radiological database of 2 university hospitals was screened for patients with trauma of unknown origin and unclear finding situation investigated by whole body CT...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046663/reclassification-of-paenibacillus-riograndensis-as-a-genomovar-of-paenibacillus-sonchi-genome-based-metrics-improve-bacterial-taxonomic-classification
#3
Fernando H Sant'Anna, Adriana Ambrosini, Rocheli de Souza, Gabriela de Carvalho Fernandes, Evelise Bach, Eduardo Balsanelli, Valter Baura, Luciana F Brito, Volker F Wendisch, Fábio de Oliveira Pedrosa, Emanuel M de Souza, Luciane M P Passaglia
Species from the genus Paenibacillus are widely studied due to their biotechnological relevance. Dozens of novel species descriptions of this genus were published in the last couple of years, but few utilized genomic data as classification criteria. Here, we demonstrate the importance of using genome-based metrics and phylogenetic analyses to identify and classify Paenibacillus strains. For this purpose, Paenibacillus riograndensis SBR5(T), Paenibacillus sonchi X19-5(T), and their close relatives were compared through phenotypic, genotypic, and genomic approaches...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29045740/adding-vancomycin-to-perioperative-prophylaxis-decreases-deep-sternal-wound-infections-in-high-risk-cardiac-surgery-patients
#4
Sylvia Reineke, Thierry P Carrel, Verena Eigenmann, Brigitta Gahl, Urs Fuehrer, Christian Seidl, David Reineke, Eva Roost, Magi Bächli, Jonas Marschall, Lars Englberger
OBJECTIVES: Perioperative prophylaxis with cephalosporins reduces sternal wound infections (SWIs) after cardiac surgery. However, more than 50% of coagulase-negative staphylococci, an important pathogen, are cephalosporin resistant. The aim of this study was to determine the impact of adjunctive vancomycin on SWIs in high-risk patients. METHODS: We conducted a pre- and postintervention study in an academic hospital. Preintervention (2010-2011), all patients received prophylaxis with 1...
October 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29038221/prazosin-during-threat-discrimination-boosts-memory-of-the-safe-stimulus
#5
Philipp Homan, Qi Lin, James W Murrough, Laili Soleimani, Dominik R Bach, Roger L Clem, Daniela Schiller
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29037377/thermographic-imaging-in-sports-and-exercise-medicine-a-delphi-study-and-consensus-statement-on-the-measurement-of-human-skin-temperature
#6
REVIEW
Danilo Gomes Moreira, Joseph T Costello, Ciro J Brito, Jakub G Adamczyk, Kurt Ammer, Aaron J E Bach, Carlos M A Costa, Clare Eglin, Alex A Fernandes, Ismael Fernández-Cuevas, José J A Ferreira, Damiano Formenti, Damien Fournet, George Havenith, Kevin Howell, Anna Jung, Glen P Kenny, Eleazar S Kolosovas-Machuca, Matthew J Maley, Arcangelo Merla, David D Pascoe, Jose I Priego Quesada, Robert G Schwartz, Adérito R D Seixas, James Selfe, Boris G Vainer, Manuel Sillero-Quintana
The importance of using infrared thermography (IRT) to assess skin temperature (tsk) is increasing in clinical settings. Recently, its use has been increasing in sports and exercise medicine; however, no consensus guideline exists to address the methods for collecting data in such situations. The aim of this study was to develop a checklist for the collection of tsk using IRT in sports and exercise medicine. We carried out a Delphi study to set a checklist based on consensus agreement from leading experts in the field...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29035562/quantification-of-membrane-protein-detergent-complex-interactions
#7
Aaron John Wolfe, Wei Si, Zhengqi Zhang, Adam R Blanden, Yi-Ching Hsueh, Jack Fredrick Gugel, Bach Pham, Min Chen, Stewart N Loh, Sharon Rozovsky, Aleksei Aksimentiev, Liviu Movileanu
Although fundamentally significant in structural, chemical, and membrane biology, the interfacial protein-detergent complex (PDC) interactions have been modestly examined because of the complicated behavior of both detergents and membrane proteins in aqueous phase. Membrane proteins are prone to unproductive aggregation resulting from poor detergent solvation, but the participating forces in this phenomenon remain ambiguous. Here, we show that using rational membrane protein design, targeted chemical modification, and steady-state fluorescence polarization spectroscopy, the detergent desolvation of membrane proteins can be quantitatively evaluated...
October 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29034905/the-hygiene-hypothesis-in-autoimmunity-the-role-of-pathogens-and-commensals
#8
REVIEW
Jean-François Bach
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the incidence of most infectious diseases has declined. This observation gave rise to the hygiene hypothesis, which postulates that a reduction in the frequency of infections contributes directly to the increase in the frequency of autoimmune and allergic diseases. This hypothesis is supported by robust epidemiological data, but the underlying mechanisms are unclear. Pathogens are known to be important, as autoimmune disease is prevented in various experimental models by infection with different bacteria, viruses and parasites...
October 16, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29033874/testing-the-motor-simulation-account-of-source-errors-for-actions-in-recall
#9
Nicholas Lange, Timothy J Hollins, Patric Bach
Observing someone else perform an action can lead to false memories of self-performance - the observation inflation effect. One explanation is that action simulation via mirror neuron activation during action observation is responsible for observation inflation by enriching memories of observed actions with motor representations. In three experiments we investigated this account of source memory failures, using a novel paradigm that minimized influences of verbalization and prior object knowledge. Participants worked in pairs to take turns acting out geometric shapes and letters...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29031187/modelling-transitions-in-urban-water-systems
#10
W Rauch, C Urich, P M Bach, B C Rogers, F J de Haan, R R Brown, M Mair, D T McCarthy, M Kleidorfer, R Sitzenfrei, A Deletic
Long term planning of urban water infrastructure requires acknowledgement that transitions in the water system are driven by changes in the urban environment, as well as societal dynamics. Inherent to the complexity of these underlying processes is that the dynamics of a system's evolution cannot be explained by linear cause-effect relationships and cannot be predicted under narrow sets of assumptions. Planning therefore needs to consider the functional behaviour and performance of integrated flexible infrastructure systems under a wide range of future conditions...
September 22, 2017: Water Research
https://www.readbyqxmd.com/read/29029245/host-transcription-profile-in-nasal-epithelium-and-whole-blood-of-hospitalised-children-under-two-years-of-age-with-respiratory-syncytial-virus-infection
#11
Lien Anh Ha Do, Johann Pellet, H Rogier van Doorn, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Huu Mai Khanh Nguyen, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Bertrand De Meulder, Charles Auffray, Jorrit-Jan Hofstra, Jeremy Farrar, Juliet E Bryant, Menno de Jong, Martin L Hibberd
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028751/injuries-to-the-female-athlete-in-2017-part-ii-upper-and-lower-extremity-injuries
#12
Rachel M Frank, Anthony A Romeo, Charles A Bush-Joseph, Bernard R Bach
No abstract text is available yet for this article.
October 12, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/29028750/injuries-to-the-female-athlete-in-2017-part-i-general-considerations-concussions-stress-fractures-and-the-female-athlete-triad
#13
Rachel M Frank, Anthony A Romeo, Charles A Bush-Joseph, Bernard R Bach
No abstract text is available yet for this article.
October 12, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/29024130/continuity-between-dsm-5-section-ii-and-section-iii-personality-traits-for-obsessive-compulsive-personality-disorder
#14
Jacqueline Liggett, Martin Sellbom, Bo Bach
OBJECTIVE: Obsessive-compulsive personality disorder (OCPD) is formally operationalized in Section II of the DSM-5 by a heterogeneous collection of 8 categorical criteria. Section III contains an alternative model operationalizing personality disorders via dimensional personality traits and associated impairment. The extent to which the personality traits used to define OCPD in Section III correspond with the Section II operationalization of the disorder is contested. The current study aims to contribute to the evidence base necessary to solidify the optimal trait profile for this disorder via a more fine-tuned examination of OCPD...
October 11, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29022007/is-uterine-preservation-combined-with-bilateral-salpingo-oophorectomy-to-promote-subsequent-fertility-safe-in-infiltrative-mucinous-ovarian-cancer
#15
Sebastien Gouy, Marine Saidani, Amandine Maulard, Matthieu Faron, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
According to the latest World Health Organization classification (2014), mucinous ovarian cancers should be classified histologically as being either expansile or infiltrative. Compared to other epithelial cancers, both of these mucinous patterns are diagnosed, in the main, at an early stage, although they can affect relatively young patients. The infiltrative subtype is characterized by a morphologically and clinically more aggressive disease versus the expansile form. Consequently, even in young patients who would prefer fertility sparing management, the removal of both ovaries (even for a unilateral tumor) remains a common recommendation...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29021977/the-consensus-from-the-mycobacterium-avium-ssp-paratuberculosis-map-conference-2017
#16
J Todd Kuenstner, Saleh Naser, William Chamberlin, Thomas Borody, David Y Graham, Adrienne McNees, John Hermon-Taylor, Amy Hermon-Taylor, C Thomas Dow, Walter Thayer, James Biesecker, Michael T Collins, Leonardo A Sechi, Shoor Vir Singh, Peilin Zhang, Ira Shafran, Stuart Weg, Grzegorz Telega, Robert Rothstein, Harry Oken, Stephen Schimpff, Horacio Bach, Tim Bull, Irene Grant, Jay Ellingson, Heinrich Dahmen, Judith Lipton, Saurabh Gupta, Kundan Chaubey, Manju Singh, Prabhat Agarwal, Ashok Kumar, Jyoti Misri, Jagdip Sohal, Kuldeep Dhama, Zahra Hemati, William Davis, Michael Hier, John Aitken, Ellen Pierce, Nicole Parrish, Neil Goldberg, Maher Kali, Sachin Bendre, Gaurav Agrawal, Robert Baldassano, Preston Linn, Raymond W Sweeney, Marie Fecteau, Casey Hofstaedter, Raghava Potula, Olga Timofeeva, Steven Geier, Kuruvilla John, Najah Zayanni, Hoda M Malaty, Christopher Kahlenborn, Amanda Kravitz, Adriano Bulfon, George Daskalopoulos, Hazel Mitchell, Brett Neilan, Verlaine Timms, Davide Cossu, Giuseppe Mameli, Paul Angermeier, Tomislav Jelic, Ralph Goethe, Ramon A Juste, Lauren Kuenstner
On March 24 and 25, 2017 researchers and clinicians from around the world met at Temple University in Philadelphia to discuss the current knowledge of Mycobacterium avium ssp. paratuberculosis (MAP) and its relationship to human disease. The conference was held because of shared concern that MAP is a zoonotic bacterium that poses a threat not only to animal health but also human health. In order to further study this problem, the conferees discussed ways to improve MAP diagnostic tests and discussed potential future anti-MAP clinical trials...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29020996/quality-of-life-profile-of-general-vietnamese-population-using-eq-5d-5l
#17
Long Hoang Nguyen, Bach Xuan Tran, Quynh Ngoc Hoang Le, Tung Thanh Tran, Carl A Latkin
BACKGROUND: Health-related quality of life (HRQOL) is a vital benchmark to assess the effects of health interventions and policies. Measuring HRQOL of the general population is essential to establish a reference for health outcomes evaluations. However, evidence on HRQOL of general populations in low and middle income countries is very limited. This study aimed to measure HRQOL of the Vietnamese population by using the EuroQol-5 dimensions-5 levels (EQ-5D-5L) instrument and determine its associated factors...
October 11, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29018372/neurodiversity-giftedness-and-aesthetic-perceptual-judgment-of-music-in-children-with-autism
#18
Nobuo Masataka
The author investigated the capability of aesthetic perceptual judgment of music in male children diagnosed with autism spectrum disorder (ASD) when compared to age-matched typically developing (TD) male children. Nineteen boys between 4 and 7 years of age with ASD were compared to 28 TD boys while listening to musical stimuli of different aesthetic levels. The results from two musical experiments using the above participants, are described here. In the first study, responses to a Mozart minuet and a dissonant altered version of the same Mozart minuet were compared...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29018243/6e11-a-highly-selective-inhibitor-of-receptor-interacting-protein-kinase-1-protects-cells-against-cold-hypoxia-reoxygenation-injury
#19
C Delehouzé, S Leverrier-Penna, F Le Cann, A Comte, M Jacquard-Fevai, O Delalande, N Desban, B Baratte, I Gallais, F Faurez, M C Bonnet, M Hauteville, P G Goekjian, R Thuillier, F Favreau, P Vandenabeele, T Hauet, M T Dimanche-Boitrel, S Bach
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein Kinase 1) and RIPK3, and a pseudo-kinase MLKL (Mixed Lineage Kinase domain-Like) associated in a multi-protein complex called necrosome. In order to find new inhibitors for use in human therapy, a chemical library containing highly diverse chemical structures was screened using a cell-based assay...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993215/surveying-selected-european-feed-and-livestock-production-chains-for-features-enabling-the-case-specific-post-market-monitoring-of-livestock-for-intake-and-potential-health-impacts-of-animal-feeds-derived-from-genetically-modified-crops
#20
Gijs Kleter, Sarah McFarland, Alex Bach, Umberto Bernabucci, Paul Bikker, Luca Busani, Esther Kok, Kaloyan Kostov, Anna Nadal, Maria Pla, Bruno Ronchi, Marta Terre, Ralf Einspanier
This review, which has been prepared within the frame of the European Union (EU)-funded project MARLON, surveys the organisation and characteristics of specific livestock and feed production chains (conventional, organic, GM-free) within the EU, with an emphasis on controls, regulations, traceability, and common production practices. Furthermore, an overview of the origin of animal feed used in the EU as well as an examination of the use of genetically modified organisms (GMOs) in feed is provided. From the data, it shows that livestock is traceable at the herd or individual level, depending on the species...
October 6, 2017: Food and Chemical Toxicology
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