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https://www.readbyqxmd.com/read/28645849/thermal-management-in-closed-incubators-new-software-for-assessing-the-impact-of-humidity-on-the-optimal-incubator-air-temperature
#1
Stéphane Delanaud, Pauline Decima, Amandine Pelletier, Jean-Pierre Libert, Estelle Durand, Erwan Stephan-Blanchard, Véronique Bach, Pierre Tourneux
BACKGROUND: Low-birth-weight (LBW) neonates are nursed in closed incubators to prevent transcutaneous water loss. The RH's impact on the optimal incubator air temperature setting has not been studied. METHODS: On the basis of a clinical cohort study, we modelled all the ambient parameters influencing body heat losses and gains. The algorithm quantifies the change in RH on the air temperature, to maintain optimal thermal conditions in the incubator. RESULTS: Twenty-three neonates (gestational age (GA): 30...
June 20, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28639925/causes-of-avascular-hypoechoic-testicular-lesions-detected-at-scrotal-ultrasound-can-they-be-considered-benign
#2
Weining Ma, Debra Sarasohn, Junting Zheng, Hebert A Vargas, Ariadne Bach
OBJECTIVE: The purposes of this study were to determine the cause of avascular hypoechoic lesions detected at scrotal ultrasound and to assess usefulness of sonographic and clinical features in differentiating benign from malignant etiologic factors. MATERIALS AND METHODS: This retrospective study included 58 patients with avascular hypoechoic lesions detected at testicular ultrasound. The sonographic features recorded were lesion size and margins and presence of peripheral vascularity and focal calcifications...
July 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28638621/the-role-of-dsm-5-borderline-personality-symptomatology-and-traits-in-the-link-between-childhood-trauma-and-suicidal-risk-in-psychiatric-patients
#3
Bo Bach, Rita Fjeldsted
BACKGROUND: Childhood traumas appear to be linked to suicidal behavior. However, the factors that mediate between these two phenomena are not sufficiently understood. Recent findings suggest that borderline personality disorder (BPD) may explain some of the association. METHOD: The present study investigated the potential mediating role of BPD symptomatology and traits between reported childhood trauma and suicidal risk in adult psychiatric outpatients (N = 124)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28633932/%C3%AE-2-adrenoreceptor-stimulation-dampens-the-lps-induced-m1-polarization-in-pig-macrophages
#4
Elodie Bacou, Karine Haurogné, Marie Allard, Grégoire Mignot, Jean-Marie Bach, Julie Hervé, Blandine Lieubeau
The cross-talk between sympatho-adreno-medullar axis and innate immunity players was mainly studied in rodents. In intensive husbandry, pigs are exposed to multiple stressors inducing repeated releases of catecholamines that bind to adrenoreceptors (AR) on target cells. Among adrenoreceptors, the β2-AR is largely expressed by immune cells including macrophages. We report herein on the effects of catecholamines, through β2-AR stimulation, on pig macrophage functions activated by LPS. β2-AR stimulation of porcine macrophages prevented the LPS-induced increase in TNFα and IL-8 secretion while increasing IL-10 secretion...
June 17, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28633673/the-influence-of-total-hysterectomy-in-a-cervical-cancer-screening-population-a-register-based-cross-sectional-study
#5
Mette Bach Larsen, Ellen M Mikkelsen, Ulla Jeppesen, Hans Svanholm, Berit Andersen
BACKGROUND: High coverage of a screening program is essential to program success. Many European screening programs cover only 10-80% of their target population. A possible explanation for the low coverage may be that some women in the screening population have had a total hysterectomy, thus they are not at risk of cervical cancer. The aim of this study was to identify the prevalence of hysterectomy in the target population of the Danish National Cervical Cancer Screening Program (NCCSP) and to recalculate coverage after excluding women with total hysterectomy...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28632307/association-of-coloproctology-of-great-britain-ireland-acpgbi-guidelines-for-the-management-of-cancer-of-the-colon-rectum-and-anus-2017-multidisciplinary-management
#6
Simon Gollins, Brendan Moran, Richard Adams, Chris Cunningham, Simon Bach, Arthur Sun Myint, Andrew Renehan, Sharad Karandikar, Vicky Goh, Davide Prezzi, Gerald Langman, Sam Ahmedzai, Ian Geh
No abstract text is available yet for this article.
July 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28631600/inhibition-of-carbonic-anhydrase-ix-by-ureidosulfonamide-inhibitor-u104-reduces-prostate-cancer-cell-growth-but-does-not-modulate-daunorubicin-or-cisplatin-cytotoxicity
#7
Anne Riemann, Antje Güttler, Verena Haupt, Henri Wichmann, Sarah Reime, Matthias Bache, Dirk Vordermark, Oliver Thews
Carbonic anhydrase IX has emerged as a promising target for cancer therapy. It is highly up-regulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells in concern of potential therapeutic implications...
June 19, 2017: Oncology Research
https://www.readbyqxmd.com/read/28628638/temperature-and-concentration-calibration-of-aqueous-polyvinylpyrrolidone-pvp-solutions-for-isotropic-diffusion-mri-phantoms
#8
Friedrich Wagner, Frederik B Laun, Tristan A Kuder, Anna Mlynarska, Florian Maier, Jonas Faust, Kerstin Demberg, Linus Lindemann, Boris Rivkin, Armin M Nagel, Mark E Ladd, Klaus Maier-Hein, Sebastian Bickelhaupt, Michael Bach
To use the "apparent diffusion coefficient" (Dapp) as a quantitative imaging parameter, well-suited test fluids are essential. In this study, the previously proposed aqueous solutions of polyvinylpyrrolidone (PVP) were examined and temperature calibrations were obtained. For example, at a temperature of 20°C, Dapp ranged from 1.594 (95% CI: 1.593, 1.595) μm2/ms to 0.3326 (95% CI: 0. 3304, 0.3348) μm2/ms for PVP-concentrations ranging from 10% (w/w) to 50% (w/w) using K30 polymer lengths. The temperature dependence of Dapp was found to be so strong that a negligence seems not advisable...
2017: PloS One
https://www.readbyqxmd.com/read/28628515/effectiveness-of-self-administered-decision-aids-for-people-invited-to-participate-in-colorectal-cancer-screening-a-systematic-review-protocol
#9
Mette Bach Larsen, Pernille Gabel, Berit Andersen
The objective is to assess the effectiveness of self-administered decision aids for people invited to participate in colorectal cancer screening. We will evaluate effects on informed choice, decisional conflict, knowledge, and participation in colorectal cancer screening.
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28626018/dissecting-the-function-of-hippocampal-oscillations-in-a-human-anxiety-model
#10
Saurabh Khemka, Gareth Barnes, Raymond J Dolan, Dominik R Bach
Neural oscillations in hippocampus and medial prefrontal cortex (mPFC) are a hallmark of rodent anxiety models that build on conflict between approach and avoidance. Yet, the function of these oscillations, and their expression in humans, remain elusive. Here, we used magnetoencephalography (MEG) to investigate neural oscillations in a task that simulated approach-avoidance conflict, wherein 23 male and female human participants collected monetary tokens under a threat of virtual predation. Probability of threat was learned beforehand by direct experience...
June 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28624320/prognostic-value-of-the-vhl-hif-1%C3%AE-and-vegf-signaling-pathway-and-associated-mapk-erk1-2-and-erk5-pathways-in-clear-cell-renal-cell-carcinoma-a-long-term-study
#11
Antonio S Salinas-Sánchez, Leticia Serrano-Oviedo, Syongh Y Nam-Cha, Olga Roche-Losada, Ricardo Sánchez-Prieto, José M Giménez-Bachs
BACKGROUND: The prognostic value of molecular markers in renal cell carcinoma has been investigated in several studies. Although their value is still not confirmed, various proteins are important. We describe the effect on long-term survival of the status of the von Hippel-Lindau (VHL) hypoxia-inducible factor 1-α (HIF1-α) signaling pathway as well as associated mitogen-activated protein kinase (extracellular signal-regulated kinase [ERK]1/2 and ERK5). PATIENTS AND METHODS: A prospective, longitudinal cohort study was conducted with 50 patients diagnosed with clear-cell renal cell carcinoma to analyze VHL mutations and hypermethylation as well as VHL, HIF1-α, vascular endothelial growth factor (VEGF), ERK1/2, and ERK5 protein expression...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28621669/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#12
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28620086/a-genetic-screen-reveals-an-unexpected-role-for-yorkie-signaling-in-jak-stat-dependent-hematopoietic-malignancies-in-drosophila-melanogaster
#13
Abigail M Anderson, Alessandro A Bailetti, Elizabeth Rodkin, Atish De, Erika A Bach
A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2(V617F) ) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulators and targets of JAK/STAT signaling that may represent additional clinical interventions. Drosophila melanogaster offers a low complexity model to study MPNs as JAK/STAT signaling is simplified with only one JAK (Hopscotch (Hop)) and one STAT (Stat92E)...
June 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28602161/cytoprotective-effect-exerted-by-geraniin-in-hepg2-cells-is-through-microrna-mediated-regulation-of-bach-1-and-ho-1
#14
Hoda Aayadi, Smriti P K Mittal, Anjali Deshpande, Makarand Gore, Saroj S Ghaskadbi
Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta (GSK-3β). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA...
June 12, 2017: BMB Reports
https://www.readbyqxmd.com/read/28600857/quantification-of-tumor-uptake-with-molecular-breast-imaging
#15
Steven T Bache, Cheenu Kappadath
PURPOSE: We developed scatter and attenuation correction techniques for quantifying images obtained with Molecular Breast Imaging (MBI) systems. METHODS: To investigate scatter correction, energy spectra of a (99m) Tc point source were acquired with 0-7-cm-thick acrylic to simulate scatter between the detector heads. System-specific scatter correction factor, k, was calculated as a function of thickness using a dual-energy-window technique. To investigate attenuation correction, a 7-cm-thick rectangular phantom containing (99m) Tc-water simulating breast tissue and fillable spheres simulating tumors was imaged...
June 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28597547/controlled-growth-of-monocrystalline-organo-lead-halide-perovskite-and-its-application-in-photonic-devices
#16
Wenxin Mao, Jialu Zheng, Yupeng Zhang, Anthony S R Chesman, Qingdong Ou, Jamie Hicks, Feng Li, Ziyu Wang, Brenton Graystone, Toby Bell, Mathias Uller Rothmann, Noel Duffy, Yibing Cheng, Leone Spiccia, Qiaoliang Bao, Udo Bach
Organo-lead halide perovskites as a new class of exceptional optoelectronic materials has been found use in many applications. However, conventional methods for forming single crystals of OHPs afford limited control over the product morphology, rendering the assembly of defined microstructures difficult. We overcame this by synthesising for the first time (MA)[PbBr3]·DMF (1), and demonstrating its facile transformation into monocrystalline MAPbBr3 microplatelets, which exhibit excellent waveguiding porperty with an ultra-low propagation loss of 0...
June 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28597127/the-interaction-between-smoking-and-hla-genes-in-multiple-sclerosis-replication-and-refinement
#17
Anna Karin Hedström, Michail Katsoulis, Ola Hössjer, Izaura L Bomfim, Annette Oturai, Helle Bach Sondergaard, Finn Sellebjerg, Henrik Ullum, Lise Wegner Thørner, Marte Wendel Gustavsen, Hanne F Harbo, Dragana Obradovic, Milena A Gianfrancesco, Lisa F Barcellos, Catherine A Schaefer, Jan Hillert, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Interactions between environment and genetics may contribute to multiple sclerosis (MS) development. We investigated whether the previously observed interaction between smoking and HLA genotype in the Swedish population could be replicated, refined and extended to include other populations. We used six independent case-control studies from five different countries (Sweden, Denmark, Norway, Serbia, United States). A pooled analysis was performed for replication of previous observations (7190 cases, 8876 controls)...
June 8, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28595642/adherence-to-methadone-maintenance-treatment-and-associated-factors-among-patients-in-vietnamese-mountainside-areas
#18
Long Hoang Nguyen, Huong Thu Thi Nguyen, Huong Lan Thi Nguyen, Bach Xuan Tran, Carl A Latkin
BACKGROUND: Medication adherence is essential to achieve successful methadone maintenance treatment (MMT). However, treatment adherence among MMT patients in the mountainous setting in Vietnam has not been yet investigated. This study aimed to explore the medication adherence and associated factors in MMT patients in Tuyen Quang, a mountainous province. METHODS: A cross-sectional survey was conducted in two MMT clinics namely Tuyen Quang and Son Duong. Convenience sampling method was used to recruit patients...
June 8, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28590735/peptidyl-prolyl-model-study-how-does-the-electronic-effect-influence-the-amide-bond-conformation
#19
Pavel K Mykhailiuk, Vladimir Kubyshkin, Thorsten Bach, Nediljko Budisa
The triple-helical structure of collagen, the most abundant protein in animal bodies, owes its stability to post-translationally installed hydroxyl groups at position 4 of prolyl residues. To shed light on the nature of this phenomenon, we have examined the influence of the 4-substituent on the amide isomerism in peptidyl-prolyl analogues. The rigid bicyclic skeleton of 2,4-methanoprolines allowed us to follow the through-bond impact of the substituent group (electronic effect) without the side-chain conformation being affected by a stereoelectronic effect...
June 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28590315/revision-acl-reconstruction-a-critical-analysis-review
#20
Brandon J Erickson, Gregory L Cvetanovich, Rachel M Frank, Andrew J Riff, Bernard R Bach
No abstract text is available yet for this article.
June 6, 2017: JBJS Reviews
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