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https://www.readbyqxmd.com/read/28081175/understanding-the-goals-of-everyday-instrumental-actions-is-primarily-linked-to-object-not-motor-kinematic-information-evidence-from-fmri
#1
Toby Nicholson, Matt Roser, Patric Bach
Prior research conceptualised action understanding primarily as a kinematic matching of observed actions to own motor representations but has ignored the role of object information. The current study utilized fMRI to identify (a) regions uniquely involved in encoding the goal of others' actions, and (b) to test whether these goal understanding processes draw more strongly on regions involved in encoding object semantics or movement kinematics. Participants watched sequences of instrumental actions while attending to either the actions' goal (goal task), the movements performed (movement task) or the objects used (object task)...
2017: PloS One
https://www.readbyqxmd.com/read/28069899/lps-infusion-suppresses-serum-fgf21-levels-in-healthy-adult-volunteers
#2
Esben Stistrup Lauritzen, Nikolaj Rittig, Ermina Bach, Niels Moller, Mette Bjerre
CONTEXT: During the inflammatory acute phase response plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid reducing actions, but its role in the acute inflammatory response in human is unknown. OBJECTIVE: To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion. DESIGN: Two randomized, single blinded, placebo-controlled crossover trials were used...
January 9, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28068441/changes-in-astigmatism-densitometry-and-aberrations-after-smile-for-low-to-high-myopic-astigmatism-a-12-month-prospective-study
#3
Iben Bach Pedersen, Anders Ivarsen, Jesper Hjortdal
PURPOSE: To evaluate 12-month changes in refraction, visual outcome, corneal densitometry, and postoperative aberrations after small incision lenticule extraction (SMILE) for myopic astigmatism. METHODS: This 12-month prospective clinical trial comprised 101 eyes (101 patients) treated with SMILE for myopic astigmatism with cylinder of 0.75 to 4.00 diopters (D). The preoperative, 1-week, and 1-, 3-, 6-, 9-, and 12-month examinations included measurement of manifest refraction, uncorrected distance visual acuity (UDVA), and corrected (CDVA) distance visual acuity...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28060791/effects-of-infant-formula-supplemented-with-prebiotics-compared-with-synbiotics-on-growth-up-to-the-age-of-12-months-a-randomized-controlled-trial
#4
Hania Szajewska, Marek Ruszczyński, Henryk Szymański, Iwona Sadowska-Krawczenko, Anna Piwowarczyk, Preben Bødstrup Rasmussen, Mette Bach Kristensen, Christina E West, Olle Hernell
BACKGROUND: Growth is an essential outcome measure for evaluating the safety of infant formulas (IF). We investigated the effects of consumption of IF supplemented with prebiotics (fructooligosaccharides, FOS, and galactooligosaccharides, GOS) compared with synbiotics (FOS/GOS and Lactobacillus paracasei ssp. paracasei strain F19) on the growth of healthy infants. METHODS: 182 full-term infants who were weaned completely from breast milk to IF at 28 days of age were randomly assigned to receive prebiotic- or synbiotic-supplemented, otherwise identical, IF until 6 months of age (intervention period)...
January 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28059327/coherent-supercontinuum-bandwidth-limitations-under-femtosecond-pumping-at-2-%C3%A2%C2%B5m-in-all-solid-soft-glass-photonic-crystal-fibers
#5
Mariusz Klimczak, Bartłomiej Siwicki, Binbin Zhou, Morten Bache, Dariusz Pysz, Ole Bang, Ryszard Buczyński
Two all-solid glass photonic crystal fibers with all-normal dispersion profiles are evaluated for coherent supercontinuum generation under pumping in the 2.0 μm range. In-house boron-silicate and commercial lead-silicate glasses were used to fabricate fibers optimized for either flat dispersion, albeit with lower nonlinearity, or with larger dispersion profile curvature but with much higher nonlinearity. Recorded spectra at the redshifted edge reached 2500-2800 nm depending on fiber type. Possible factors behind these differences are discussed with numerical simulations...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28058804/pesticide-exposure-assessment-for-surface-waters-in-the-eu-part-2-determination-of-statistically-based-runoff-and-drainage-scenarios-for-germany
#6
Martin Bach, Mirjam Diesner, Dietlinde Großmann, Djamal Guerniche, Udo Hommen, Michael Klein, Roland Kubiak, Alexandra Müller, Thomas G Preuss, Jan Priegnitz, Stefan Reichenberger, Kai Thomas, Matthias Trapp
BACKGROUND: In order to assess surface water exposure to active substances of plant protection products (PPP) in the EU, the FOCUS (FOrum for the Co-ordination of pesticide fate models and their USe) surface water workgroup introduced four runoff and six drainage scenarios for Step 3 of the tiered FOCUSsw approach. These scenarios may not necessarily represent realistic worst-case situations for the different Member States of the EU. Hence, the suitability of the scenarios for risk assessment in the national authorisation procedures is not known...
January 6, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28056990/stigmatization-among-methadone-maintenance-treatment-patients-in-mountainous-areas-in-northern-vietnam
#7
Hung Van Nguyen, Huong Lan Thi Nguyen, Hue Thi Mai, Hai Quan Le, Bach Xuan Tran, Canh Dinh Hoang, Huong Thi Le, Cuong Tat Nguyen, Tho Dinh Tran, Carl A Latkin, Thuc Minh Thi Vu
BACKGROUND: Stigma and discrimination may adversely affect the benefits of methadone maintenance treatment (MMT) for drug users, especially in disadvantaged settings. This study assessed stigma and discrimination against MMT patients in the mountainous and rural areas in Vietnam and explored their associated factors to inform implementation strategies. METHODS: We interviewed 241 MMT patients in two clinics: one in Tuyen Quang Province's inner city and the other in Son Duong District, to assess stigma and discrimination that patients perceived and experienced...
January 6, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28055110/survivorship-after-lower-gastrointestinal-cancer-patient-reported-outcomes-and-planning-for-care
#8
Melissa A Frick, Carolyn C Vachani, Margaret K Hampshire, Christina Bach, Karen Arnold-Korzeniowski, James M Metz, Christine E Hill-Kayser
BACKGROUND: There is significant need for quality follow-up care to optimize long-term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient-reported outcomes (PROs) provide valuable information regarding late and long-term effects (LLTEs). METHODS: A convenience sample from 1129 colon, rectal, and anal cancer survivors (n = 792; 218, and 119, respectively) who participated in an Internet-based survivorship care plan (SCP) tool between May 2010 and October 2014 was used to examine patient-reported demographics, treatment, and toxicity data...
January 5, 2017: Cancer
https://www.readbyqxmd.com/read/28049917/synthesis-docking-study-and-kinase-inhibitory-activity-of-a-number-of-new-substituted-pyrazolo-3-4-c-pyridines
#9
Meropi Sklepari, Nikolaos Lougiakis, Athanasios Papastathopoulos, Nicole Pouli, Panagiotis Marakos, Vassilios Myrianthopoulos, Thomas Robert, Stéphane Bach, Emmanuel Mikros, Sandrine Ruchaud
A series of new pyrazolo[3,4-c]pyridines bearing various 1, 3, 5 or 1, 3, 7 pattern substitutions, were designed and synthesized. Some of them showed interesting inhibitory activity mainly against glycogen synthase kinase 3 (GSK3)α/β as well as against cdc2-like kinases 1 (CLK1) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with good selectivity and remarkable structure-activity relationships (SARs), without being cytotoxic. Molecular simulations in correlation with biological data revealed the importance of the existence of N1-H as well as the absence of a bulky 7-substituent...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28048373/th-cd-207b-12-quantification-of-clinical-feedback-on-image-quality-differences-between-two-ct-scanner-models
#10
S Bache, X Liu, E Loyer, J Rong
PURPOSE: This work sought to quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on noise and low-contrast detectability (LCD). METHODS: A water phantom and a Kagaku anthropomorphic body phantom were scanned on GE Discovery CT750 HD and LightSpeed VCT scanners (4 each) with identical scan parameters and reconstructed to 2.5mm/5.0mm thicknesses. Images of water phantom were analyzed at the scanner console with a built-in LCD tool that uses statistical methods to compute requisite CT-number contrast for 95% confidence in detection of a user-defined object size...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048321/su-g-206-08-how-should-focal-spot-be-chosen-for-optimized-ct-imaging-with-dose-modulation
#11
S Bache, X Liu, J Rong
PURPOSE: To choose the preferred focal spot for achieving optimized CT image quality with balanced tube heating considerations. METHODS: An anthropomorphic pelvic phantom was scanned using a GE Discovery CT750 HD at 120 and 140kVp, 0.8s rotation time, and pitch of 0.984. "Smart mA" was enabled to simulate a routine abdomen-pelvis CT scan. Permissible mA values at 120 and 140 kVp were obtained from the Serial Load Rating table (for mimicking a busy CT clinical operation) in the scanner Technical Reference Manual...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048285/su-g-tep1-12-random-repainting-as-mitigation-for-scanned-ion-beam-interplay-effects
#12
M Bach, J Wulff
PURPOSE: Interference of dose application in scanned beam particle therapy and organ motion may lead to interplay effects with distorted dose to target volumes. Interplay effects depend on the speed and direction of the scanning beam, leading to fringed field edges (scanning parallel to organ motion direction) or over- and under-dosed regions (both directions are orthogonal). Current repainting methods can mitigate interplay effects, but are susceptible to artefacts when only a limited number of repaints are applied...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046790/su-g-206-02-impact-of-focal-spot-sizes-on-ct-image-quality
#13
S Bache, J Rong
PURPOSE: To quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on spatial resolution that could be impacted by focal spot size. METHODS: Modulation Transfer Functions (MTF) measurements were performed by scanning the impulse source insert module of the Catphan 600 at 120/140 kVp with both large (LFS) and small (SFS) focal spots and reconstructed to 2.5mm and 5.0mm thicknesses on a GE Discovery CT750 HD and a LightSpeed VCT CT scanner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045613/physician-s-office-and-hospital-outpatient-setting-in-oncology-it-s-about-prices-not-use
#14
Peter B Bach, Raina H Jain
No abstract text is available yet for this article.
January 3, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28040189/usefulness-of-echocardiography-doppler-to-reliably-predict-elevated-left-ventricular-end-diastolic-pressure-in-patients-with-pulmonary-hypertension
#15
David M Cameron, Vallerie V McLaughlin, Melvyn Rubenfire, Scott Visovatti, David S Bach
The ability of echocardiography (echo)/Doppler to predict elevated left ventricular (LV) end-diastolic pressure (EDP) specifically among patients with pulmonary hypertension is not well defined. This was a retrospective analysis of 161 patients referred to a specialized pulmonary hypertension clinic. A model based on an American Society of Echocardiography (ASE)/European Association of Echocardiography (EAE) joint statement was evaluated, and a new model was developed using univariate linear regression and multivariable logistic regression for potentially better prediction of elevated LVEDP...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28036083/isolation-of-chs-gene-from-brunfelsia-acuminata-flowers-and-its-regulation-in-anthocyanin-biosysthesis
#16
Min Li, Yu-Ting Cao, Si-Rui Ye, Muhammad Irshad, Teng-Fei Pan, Dong-Liang Qiu
Chalcone synthase gene (BaCHS) from Brunfelsia acuminata flowers was isolated using RT-PCR and RACE. The coding region of the gene is 1425-bp with an open reading frame of 1170-bp, 73-bp 5'UTR, and 172-bp 3'UTR. Its deduced protein does not have a signal peptide but does contain a cond_enzyme superfamily domain, and consists of 389 amino acids with a predicted molecular mass of 42,699 Da and a pI of 6.57. The deduced amino acid sequence of BaCHS shares 90%, 88%, 85%, 84% and 79% identity with CHS from Petunia hybrida, Nicotiana tabacum, Solanum lycopersicum, Capsicum annuum and Camellia sinensis, respectively...
December 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28031314/paracetamol-use-during-pregnancy-and-attention-and-executive-function-in-offspring-at-age-5-years
#17
Zeyan Liew, Cathrine Carlsen Bach, Robert F Asarnow, Beate Ritz, Jørn Olsen
BACKGROUND: Recent studies suggested that inutero exposure to paracetamol, the most common pain and fever medication used in pregnancy, may affect neurodevelopment in offspring. We aim to examine whether maternal use of paracetamol during pregnancy affects the attention and executive function of children at age 5 years. METHODS: We studied 1491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Prenatal paracetamol use was prospectively recorded in three telephone interviews...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28027657/the-therapeutic-effect-of-intra-articular-normal-saline-injections-for-knee-osteoarthritis
#18
Bryan M Saltzman, Timothy Leroux, Maximilian A Meyer, Bryce A Basques, Jaskarndip Chahal, Bernard R Bach, Adam B Yanke, Brian J Cole
BACKGROUND: Intra-articular normal saline (IA-NS) injections have been utilized as a placebo in a number of randomized controlled trials pertaining to the management of knee osteoarthritis (OA); however, it is believed that these "placebo" injections may have a therapeutic effect that has not been quantified in the literature. PURPOSE: To (1) quantify the effect of IA-NS injections on patient-reported outcomes (PROs) and (2) compare postinjection PROs to established minimal clinically important difference (MCID) criteria to demonstrate a potential therapeutic effect...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28017423/operating-room-performance-improves-after-proficiency-based-virtual-reality-cataract-surgery-training
#19
Ann Sofia Skou Thomsen, Daniella Bach-Holm, Hadi Kjærbo, Klavs Højgaard-Olsen, Yousif Subhi, George M Saleh, Yoon Soo Park, Morten la Cour, Lars Konge
PURPOSE: To investigate the effect of virtual reality proficiency-based training on actual cataract surgery performance. The secondary purpose of the study was to define which surgeons benefit from virtual reality training. DESIGN: Multicenter masked clinical trial. PARTICIPANTS: Eighteen cataract surgeons with different levels of experience. METHODS: Cataract surgical training on a virtual reality simulator (EyeSi) until a proficiency-based test was passed...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28005937/impact-of-socioeconomic-inequality-on-access-adherence-and-outcomes-of-antiretroviral-treatment-services-for-people-living-with-hiv-aids-in-vietnam
#20
Bach Xuan Tran, Jongnam Hwang, Long Hoang Nguyen, Anh Tuan Nguyen, Noah Reed Knowlton Latkin, Ngoc Kim Tran, Vu Thi Minh Thuc, Huong Lan Thi Nguyen, Huong Thu Thi Phan, Huong Thi Le, Tho Dinh Tran, Carl A Latkin
BACKGROUND: Ensuring an equal benefit across different patient groups is necessary while scaling up free-of-charge antiretroviral treatment (ART) services. This study aimed to measure the disparity in access, adherence, and outcomes of ART in Vietnam and the effects of socioeconomic status (SES) characteristics on the levels of inequality. METHODS: A cross-sectional study was conducted in 1133 PLWH in Vietnam. ART access, adherence, and treatment outcomes were self-reported using a structured questionnaire...
2016: PloS One
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