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https://www.readbyqxmd.com/read/28531559/per-and-polyfluoroalkyl-substances-in-firefighting-foam-concentrates-and-water-samples-collected-near-sites-impacted-by-the-use-of-these-foams
#1
Xavier Dauchy, Virginie Boiteux, Cristina Bach, Christophe Rosin, Jean-François Munoz
To extinguish large-scale fuel fires, fluorosurfactant based foams (FSBFs) were developed in the 1960s and have been used ever since. In this study, 154 per- and polyfluoroalkyl substances (PFASs) including 122 emerging PFASs used as surfactants in FSBFs were sought in nine different foam concentrates. Field investigations were also carried out in the vicinity of four sites where FSBFs are or were intensively used (two airports, a training center for firefighters and an oil storage depot after a large explosion)...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28529460/wif1-prevents-wnt5a-mediated-limk-cfl-phosphorylation-and-adherens-junction-disruption-in-human-vascular-endothelial-cells
#2
Tom Skaria, Esther Bachli, Gabriele Schoedon
BACKGROUND: Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects barrier function in human VEC through Ryk interaction. Wnt5A/Ryk signalling activates LIMK to inactivate the actin depolymerisation factor CFL by phosphorylation, promotes actin polymerisation and disrupts endothelial adherens junctions...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28525639/readmissions-after-transcatheter-aortic-valve-implantation-what-are-they-doing-right-how-can-we-do-better
#3
Devraj Sukul, David S Bach
No abstract text is available yet for this article.
May 19, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28523381/national-clinical-guidelines-for-non-surgical-treatment-of-patients-with-recent-onset-neck-pain-or-cervical-radiculopathy
#4
REVIEW
Per Kjaer, Alice Kongsted, Jan Hartvigsen, Alexander Isenberg-Jørgensen, Berit Schiøttz-Christensen, Bolette Søborg, Charlotte Krog, Christian Martin Møller, Christine Marie Bækø Halling, Henrik Hein Lauridsen, Inge Ris Hansen, Jesper Nørregaard, Karsten Juhl Jørgensen, Lars Valentin Hansen, Marie Jakobsen, Martin Bach Jensen, Martin Melbye, Peter Duel, Steffan W Christensen, Tina Myung Povlsen
PURPOSE: To summarise recommendations about 21 selected non-surgical interventions for recent onset (<12 weeks) non-specific neck pain (NP) and cervical radiculopathy (CR) based on two guidelines from the Danish Health Authority. METHODS: Two multidisciplinary working groups formulated recommendations based on the GRADE approach. RESULTS: Twelve recommendations were based on evidence and nine on consensus. Management should include information about prognosis, warning signs, and advise to remain active...
May 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28523209/using-online-respondent-driven-sampling-for-vietnamese-youths-alcohol-use-and-associated-risk-factors
#5
Melvyn W B Zhang, Bach Xuan Tran, Huong Lan Thi Nguyen, Huong Thi Le, Nguyen Hoang Long, Huong Thi Le, Nguyen Duc Hinh, Tran Dinh Tho, Bao Nguyen Le, Vu Thi Minh Thuc, Chau Ngo, Nguyen Huu Tu, Carl A Latkin, Roger Cm Ho
OBJECTIVES: The average alcohol consumption per capita among Vietnamese adults has consistently increased. Although alcohol-related disorders have been extensively studied, there is a paucity of research shedding light on this issue among Internet users. The study aimed to examine the severity of alcohol-related disorders and other associated factors that might predispose individuals towards alcohol usage in a sample of youths recruited online. METHODS: An online cross-sectional study was conducted with 1,080 Vietnamese youths...
April 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28512761/deconstructing-white-matter-connectivity-of-human-amygdala-nuclei-with-thalamus-and-cortex-subdivisions-in-vivo
#6
Aslan Abivardi, Dominik R Bach
Structural alterations in long-range amygdala connections are proposed to crucially underlie several neuropsychiatric disorders. While progress has been made in elucidating the function of these connections, our understanding of their structure in humans remains sparse and non-systematic. Harnessing diffusion-weighted imaging and probabilistic tractography in humans, we investigate connections between two main amygdala nucleus groups, thalamic nuclei, and cortex. We first parcellated amygdala into deep (basolateral) and superficial (centrocortical) nucleus groups, and thalamus into six subregions, using previously established protocols based on connectivity...
May 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28512187/neutral-competition-for-drosophila-follicle-and-cyst-stem-cell-niches-requires-vesicle-trafficking-genes
#7
Matthew S Cook, Coralie Cazin, Marc Amoyel, Shinya Yamamoto, Erika Bach, Todd Nystul
The process of selecting for cellular fitness through competition plays a critical role in both development and disease. The germarium, a structure at the tip of the ovariole of a Drosophila ovary, contains two follicle stem cells (FSCs) that undergo neutral competition for the stem cell niche. Using the FSCs as a model, we performed a genetic screen through a collection of 126 mutants in essential genes on the X chromosome to identify candidates that increase or decrease competition for the FSC niche. We identified approximately 55% and 6% of the mutations screened as putative FSC hypo- or hypercompetitors, respectively...
May 16, 2017: Genetics
https://www.readbyqxmd.com/read/28511943/relationship-between-soluble-cd25-and-gene-expression-in-healthy-individuals-and-patients-with-multiple-sclerosis
#8
Sophie Buhelt, Rikke Lenhard Ratzer, Jeppe Romme Christensen, Lars Börnsen, Finn Sellebjerg, Helle Bach Søndergaard
Genome wide association studies and fine mapping has established a firm link between the IL2RA gene, encoding the interleukin-2 receptor α-chain CD25, and susceptibility to multiple sclerosis (MS). We hypothesized that gene expression in peripheral blood mononuclear cells (PBMCs) from healthy controls (HCs) and MS patients are associated with IL2RA SNP rs2104286 and that gene expression levels correlate with soluble CD25 (sCD25) concentrations - that are affected by rs2104286. We used the Affymetrix Human Gene ST 1...
May 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28511549/radiological-findings-on-irradiation-ct-in-patients-with-non-metastatic-breast-cancer
#9
Hans Jonas Meyer, Johannes Uhlig, Dominik Schramm, Andreas Gunter Bach, Alexey Surov
OBJECTIVE: The aim of this study was to evaluate the number of incidental findings on native CT treatment planning scans for radiation in breast cancer patients. METHODS: The treatment-planning scans of 382 patients with non-metastatic breast cancer were retrospectively analyzed for additional findings. The planning scan area covered the entire thorax and the upper part of the abdomen. Incidental findings were classified according to their clinical relevance Results: Overall 892 incidental findings were detected in the CT treatment-planning scans (mean 2...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28510988/barriers-to-obstetric-fistula-treatment-in-low-income-countries-a-systematic-review
#10
REVIEW
Rachel Bach, Charlotte Warren, Zoe Baker, Ben Bellows
OBJECTIVES: To identify the barriers that women living with fistula in low-income countries face, preventing them from seeking care, reaching medical centers, and receiving appropriate care. METHODS: Bibliographic databases, grey literature, journals, and network and organization websites were searched in English and French from June to July 2014 using key search terms and specific inclusion and exclusion criteria for discussion of barriers to fistula treatment...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28504853/deriving-icd-11-personality-disorder-domains-from-dsm-5-traits-initial-attempt-to-harmonize-two-diagnostic-systems
#11
B Bach, M Sellbom, M Kongerslev, E Simonsen, R F Krueger, R Mulder
OBJECTIVE: The personality disorder domains proposed for the ICD-11 comprise Negative Affectivity, Detachment, Dissociality, Disinhibition, and Anankastia, which are reasonably concordant with the higher-order trait domains in the Alternative DSM-5 Model for Personality Disorders. METHOD: We examined (i) whether designated DSM-5 trait facets can be used to describe the proposed ICD-11 trait domains, and (ii) how these ICD-11 trait features are hierarchically organized...
May 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28504622/-severe-cervical-kyphosis-causing-sudden-inspiratory-stridor
#12
Karen Lise Dahl Andersen, Allan Bach, Rikke Haahr Iversen, Søren Helbo Skaarup
An 85-year-old woman was brought to an accident and emergency department with breathing difficulties accompanied by inspiratory stridor. She was being treated for hypertension and severe osteoporosis which had caused thoracal and cervical fractures of the columna. Intubation was initiated as she desaturated and deteriorated despite maximum oxygen therapy. The intubation revealed a subglottic stenosis as a consequence of a recent osteoporotic fracture in the cervical columna. This represents a rare cause of respiratory failure as all other cardial, pulmonary and allergic aetiologies had been eliminated...
May 8, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28503935/personality-inventory-for-dsm-5-pid-5-in-clinical-versus-nonclinical-individuals-generalizability-of-psychometric-features
#13
Bo Bach, Martin Sellbom, Erik Simonsen
The Personality Inventory for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PID-5) was developed for the assessment of pathological traits in clinical settings. However, most research on the PID-5 is derived from nonclinical samples. To date, the comparability and generalizability of PID-5 constructs across nonclinical and clinical samples have not been adequately investigated. Therefore, we investigated the measurement invariance, five-factor structure, and factor correlations across clinical and nonclinical samples...
May 1, 2017: Assessment
https://www.readbyqxmd.com/read/28501576/liraglutide-a-glucagon-like-peptide-1-analog-induce-autophagy-and-senescence-in-hepg2-cells
#14
Gabriele Catyana Krause, Kelly Goulart Lima, Henrique Bregolin Dias, Elisa Feller Gonçalves da Silva, Gabriela Viegas Haute, Bruno Souza Basso, Rodrigo Benedetti Gassen, Elisa Simon Marczak, Rafaela Sole Bach Nunes, Jarbas Rodrigues de Oliveira
It has been reported that glucagon-like peptide-1 (GLP-1) agents have been associated with both the increased risk of cancer and inhibition of tumor growth and metastases. The aim of this study is to evaluate the effect of liraglutide on hepatocellular carcinoma cells - HepG2. Cytometry was used to evaluate mechanism related to decreased cell proliferation. Nuclear staining and morphometric analysis were also used to verify the process that was taking place after treatment with liraglutide, and in order to better understand the mechanism, TGF-β1 was performed...
May 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28498117/application-of-response-surface-methodology-to-optimize-the-fabrication-of-zncl2-activated-carbon-from-sugarcane-bagasse-for-the-removal-of-cu-2
#15
Thuan Van Tran, Quynh Thi Phuong Bui, Trinh Duy Nguyen, Van Thi Thanh Ho, Long Giang Bach
The present study focused on the application of response surface methodology to optimize the fabrication of activated carbon (AC) from sugarcane bagasse for adsorption of Cu(2+) ion. The AC was synthesized via chemical activation with ZnCl2 as the activating agent. The central composite design based experiments were performed to assess the individual and interactive effect of influential parameters, including activation temperature, ZnCl2 impregnation ratio and activation time on the AC yield and removal of Cu(2+) ion from the aqueous environment...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28496414/the-systematic-bias-of-ingestible-core-temperature-sensors-requires-a-correction-by-linear-regression
#16
Andrew P Hunt, Aaron J E Bach, David N Borg, Joseph T Costello, Ian B Stewart
An accurate measure of core body temperature is critical for monitoring individuals, groups and teams undertaking physical activity in situations of high heat stress or prolonged cold exposure. This study examined the range in systematic bias of ingestible temperature sensors compared to a certified and traceable reference thermometer. A total of 119 ingestible temperature sensors were immersed in a circulated water bath at five water temperatures (TEMP A: 35.12 ± 0.60°C, TEMP B: 37.33 ± 0.56°C, TEMP C: 39...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28487992/spilanthes%C3%A2-acmella-inhibits-inflammatory-responses-via-inhibition-of-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways-in-raw-264-7-macrophages
#17
Young-Chang Cho, Tran The Bach, Ba Reum Kim, Huong Lan Vuong, Sayeon Cho
Spilanthes acmella Murr. (S. acmella) has been used traditionally in India and Sri Lanka to treat various inflammatory diseases. However, the anti‑inflammatory effects and underlying mechanism of action of S. acmella are unclear. The present study assessed the anti‑inflammatory properties of methanol extracts of S. acmella (MSA) in murine macrophages. MSA (≤300 µg/ml) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages through transcriptional inhibition of inducible nitric oxide synthase expression in a dose‑dependent manner...
May 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486523/barriers-towards-the-publication-of-academic-drug-trials-follow-up-of-trials-approved-by-the-danish-medicines-agency
#18
Louise Berendt, Lene Grejs Petersen, Karin Friis Bach, Henrik Enghusen Poulsen, Kim Dalhoff
OBJECTIVE: To characterize and quantify barriers towards the publication of academic drug trials. STUDY DESIGN: We identified academic drug trials approved during a 3-year period (2004-2007) by the Danish Medicines Agency. We conducted a survey among the trial sponsors to describe the rates of initiation, completion, and publication, and the reasons for the failure to reach each of these milestones. Information on size and methodological characteristics of the trials was extracted from the EudraCT database, a prospective register of all approved clinical drug trials submitted to European medicines agencies since 2004...
2017: PloS One
https://www.readbyqxmd.com/read/28478905/plant-rna-interactome-capture-revealing-the-plant-rbpome
#19
Marcel Bach-Pages, Alfredo Castello, Gail M Preston
The application of RNA interactome capture to plants has enabled comprehensive determination of the plant RNA-binding proteome and the identification of novel families of RNA-binding proteins (RBPs). The technique is providing insight into the evolution of the eukaryotic repertoire of RBPs and will enhance prospects for engineering RBPs to improve crop traits.
May 3, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28478865/synthesis-and-biological-activity-of-new-phthalimides-as-potential-anti-inflammatory-agents
#20
Duc-Hiep Bach, Jian-Yu Liu, Won Kyung Kim, Ji-Young Hong, So Hyun Park, Donghwa Kim, Si-Ning Qin, Thi-Thu-Trang Luu, Hyen Joo Park, Yong-Nan Xu, Sang Kook Lee
The overproduction of nitric oxide (NO) plays an important role in a variety of pathophysiological processes, including inflammation. Therefore, the suppression of NO production is a promising target in the design of anti-inflammatory agents. In the present study, a series of phthalimide analogs was synthesized, and their anti-inflammatory activities were evaluated using lipopolysaccharide (LPS)-stimulated NO production in cultured murine macrophage RAW264.7 cells. A structure-activity relationship study showed that the free hydroxyl group at C-4 and C-6 and the bulkiness of the N-substituted alkyl chain are associated with biological activity...
April 25, 2017: Bioorganic & Medicinal Chemistry
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