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https://www.readbyqxmd.com/read/28434209/urine-clusterin-apolipoprotein-j-is-linked-to-tubular-damage-and-renal-outcomes-in-patients-with-type-2-diabetes-mellitus
#1
Sang Soo Kim, Sang Heon Song, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Min-Cheol Kang, Sung Wan Chun, Soo Hyun Hong, Michelle Chung, Yong Ki Kim, In Joo Kim, Young-Bum Kim
OBJECTIVE: The objective of this study was to evaluate the association of urine clusterin/apolipoprotein J (Apo J) with the development and/or progression of diabetic kidney disease (DKD) in type 2 diabetes. MATERIALS AND METHODS: 159 type 2 diabetic patients and 20 non-diabetic subjects with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m(2) were enrolled. The baseline values of urine clusterin and tubular damage markers were measured. The primary outcome was the annual decline rate in eGFR and secondary outcomes were the development of chronic kidney disease (CKD) stage 3 or greater and the persistence/progression of albuminuria...
April 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28433415/effects-of-transferring-to-the-rehabilitation-ward-on-long-term-mortality-rate-of-first-time-stroke-survivors-a-population-based-study
#2
Chien-Min Chen, Yao-Hsu Yang, Chia-Hao Chang, Pau-Chung Chen
OBJECTIVE: To assess the long-term health outcomes of acute stroke survivors transferred to the rehabilitation ward. DESIGN: Long-term mortality rates of first-time stroke survivors during hospitalization were compared among the following sets of patients: patients transferred to the rehabilitation ward (RR), patients receiving rehabilitation without being transferred to the rehabilitation ward (NtR), and patients receiving no rehabilitation (NoR). SETTING: We conducted a five-year, nationwide, population-based, retrospective, cohort study, using data from the Longitudinal Health Insurance Database 2005 in Taiwan...
April 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28433390/a-computational-study-of-invariant-i5-in-a-nearly-incompressible-transversely-isotropic-model-for-white-matter
#3
Yuan Feng, Suhao Qiu, Xiaolong Xia, Songbai Ji, Chung-Hao Lee
The aligned axonal fiber bundles in white matter make it suitable to be modeled as a transversely isotropic material. Recent experimental studies have shown that a minimal form, nearly incompressible transversely isotropic (MITI) material model, is capable of describing mechanical anisotropy of white matter. Here, we used a finite element (FE) computational approach to demonstrate the significance of the fifth invariant (I5) when modeling the anisotropic behavior of white matter in the large-strain regime. We first implemented and validated the MITI model in an FE simulation framework for large deformations...
April 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28432692/functional-status-and-amount-of-hip-displacement-independently-affect-acetabular-dysplasia-in-cerebral-palsy
#4
Myung Ki Chung, Arif Zulkarnain, Jae Bong Lee, Byung Chae Cho, Chin Youb Chung, Kyoung Min Lee, Ki Hyuk Sung, Moon Seok Park
AIM: Acetabular dysplasia is the one of main causes of hip displacement in patients with cerebral palsy (CP). Although several studies have shown a relationship between hip displacement and acetabular dysplasia, relatively few have evaluated the association between quantitative acetabular dysplasia and related factors, such as Gross Motor Function Classification System (GMFCS) level. METHOD: We performed a morphometric analysis of the acetabulum in patients with CP using multiplanar reformation of computed tomography data...
April 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28432555/rotundarpene-inhibits-tnf-%C3%AE-induced-activation-of-the-akt-mtor-and-nf-%C3%AE%C2%BAb-pathways-and-the-jnk-and-p38-associated-with-production-of-reactive-oxygen-species
#5
Arum Kim, Yoon Jeong Nam, Yong Kyoo Shin, Min Sung Lee, Dong Suep Sohn, Chung Soo Lee
Ilex Rotunda Thunb has been shown to have anti-inflammatory and antioxidant effects. In human keratinocytes, we investigated the effect of rotundarpene (4-caffeoyl-3-methyl-but-2-ene-1,4-diol) on the TNF-α-stimulated production of inflammatory mediators in relation to the Akt, mTOR, and NF-κB pathways, and the JNK and p38-MAPK. Rotundarpene, Akt inhibitor, Bay 11-7085, rapamycin, and N-acetylcysteine inhibited the TNF-α-stimulated production of cytokines and chemokines, increase in the levels of p-Akt and mTOR, activation of NF-κB, and production of reactive oxygen species in keratinocytes...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28432440/application-of-recombinant-pediococcus-acidilactici-bd16-fcs-ech-for-bioconversion-of-agrowaste-to-vanillin
#6
Debkumar Chakraborty, Ammaiyappan Selvam, Baljinder Kaur, Jonathan Woon Chung Wong, Obulisamy Parthiba Karthikeyan
Biotechnological production of vanillin is gaining momentum as the natural synthesis of vanillin that is very expensive. Ferulic acid (FA), a costly compound, is used as the substrate to produce vanillin biotechnologically and the making process is still expensive. Therefore, this study investigated the practical use of an agrobiomass waste, rice bran, and provides the first evidence of a cost-effective production of vanillin within 24 h of incubation using recombinant Pediococcus acidilactici BD16 (fcs (+)/ech (+))...
April 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28432289/simultaneous-detection-of-egfr-and-vegf-in-colorectal-cancer-using-fluorescence-raman-endoscopy
#7
Yong-Il Kim, Sinyoung Jeong, Kyung Oh Jung, Myung Geun Song, Chul-Hee Lee, Seock-Jin Chung, Ji Yong Park, Myeong Geun Cha, Sung Gun Lee, Bong-Hyun Jun, Yun-Sang Lee, Do Won Hwang, Hyewon Youn, Keon Wook Kang, Yoon-Sik Lee, Dae Hong Jeong, Dong Soo Lee
Fluorescence endomicroscopy provides quick access to molecular targets, while Raman spectroscopy allows the detection of multiple molecular targets. Using a simultaneous fluorescence-Raman endoscopic system (FRES), we herein demonstrate its potential in cancer diagnosis in an orthotopically induced colorectal cancer (CRC) xenograft model. In the model, epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) were targeted with antibody-conjugated fluorescence and surface-enhanced Raman scattering (F-SERS) dots...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432268/clinical-outcomes-after-delayed-thyroid-surgery-in-patients-with-papillary-thyroid-microcarcinoma
#8
Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Tae Yong Kim, Young-Kee Shong, Won Bae Kim
OBJECTIVE: Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared the long-term clinical outcomes of PTMC patients according to the time interval between initial diagnosis and surgery. DESIGN & METHODS: In this individual risk factor-matched cohort study, PTMC patients were classified into three groups according to the delay period: ≤ 6 months, 6-12 months, and > 12 months...
April 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28431953/cryostored-autologous-skull-bone-for-cranioplasty-a-study-on-cranial-bone-flaps-viability-and-microbial-contamination-after-deep-frozen-storage-at-80%C3%A2-c
#9
David Yuen Chung Chan, Yi Tan Mok, Ping Kuen Lam, Cindy See Wai Tong, Stephanie Chi Ping Ng, Tin Fung David Sun, Wai Sang Poon
Craniectomy is a life-saving procedure. Subsequent cranioplasty with autologous skull bone has a bone resorption rate from 4% to 22.8% and an infection rate from 3.3% to 26%. There are concerns with their viability and the potential microbial contamination as they were explanted for a long period of time. Eighteen cranial bone flaps stored at Prince of Wales Hospital Skull Bone Bank during the period from June 2011 to March 2016 were identified. Ethics approval was obtained. Bone chips and deep bone swabs were collected for osteoblast culture and microbial culture...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28431939/modulation-of-hat-activity-by-the-brca2n372hvariation-is-a-novel-mechanism-of-paclitaxel-resistance-in-breast-cancer-cell-lines
#10
Woo Sun Kwon, Sun Young Rha, Hei-Cheul Jeung, Tae Soo Kim, Hyun Cheol Chung
Paclitaxel stabilizes microtubule polymerization, enhances microtubule assembly, andG2/M arrests, leading to cell death. Paclitaxel resistance has been attributed to a variety of mechanisms. In the present study, we define a new resistance mechanism to paclitaxel based onBRCA2variation. Chemo-sensitivity to paclitaxel based on the variations was compared. Restoration of paclitaxel sensitivity was induced indirectly with combined treatment of paclitaxel and HDAC inhibitor. Variant and wild type of BRCA2 clones were obtained from wild and variant cells, respectively...
April 18, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28431661/hwang-jh-do-ys-park-kb-chung-hh-park-hs-hyun-d-embolization-of-congenital-renal-arteriovenous-malformations-using-ethanol-and-coil-depending-on-angiographic-types-j-vasc-interv-radiol-2017-28-64-70
#11
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28431517/sharp-bounds-on-sufficient-cause-interactions-under-the-assumption-of-no-redundancy
#12
Wen-Chung Lee
BACKGROUND: Sufficient-cause interaction is a type of interaction that has received much attention recently. The sufficient component cause model on which the sufficient-cause interaction is based is however a non-identifiable model. Estimating the interaction parameters from the model is mathematically impossible. METHODS: In this paper, I derive bounding formulae for sufficient-cause interactions under the assumption of no redundancy. RESULTS: Two real data sets are used to demonstrate the method (R codes provided)...
April 21, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28431509/regular-recreational-physical-activity-and-risk-of-head-and-neck-cancer
#13
Chen-Lin Lin, Wei-Ting Lee, Chun-Yen Ou, Jenn-Ren Hsiao, Cheng-Chih Huang, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Tze-Ta Huang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Yu-Hsuan Lai, Hsiao-Chen Liao, Shang-Yin Wu, Ming-Wei Yang, Forn-Chia Lin, Jang-Yang Chang, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
BACKGROUND: Although substantial evidence supports a 20-30% risk reduction of colon cancer, breast cancer, and endometrial cancer by physical activity (PA), the evidence for head and neck cancer (HNC) is limited. Three published studies on the association between PA and HNC have generated inconsistent results. The current study examined the association between recreational PA (RPA) and HNC risk with a more detailed assessment on the intensity, frequency, duration, and total years of RPA...
April 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28431454/da-9701-improves-colonic-transit-time-and-symptoms-in-patients-with-functional-constipation-a-prospective-study
#14
Su Young Kim, Hyun Sun Woo, Sung Han Choi, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Yoon Jae Kim, Jung Ho Kim, Su Ji Kim, Kyoung Oh Kim
BACKGROUND AND AIM: DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. METHODS: We prospectively enrolled 33 patients with functional constipation based on the Rome III criteria...
April 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28431424/sleep-disordered-breathing-postoperative-delirium-and-cognitive-impairment
#15
Enoch W K Lam, Frances Chung, Jean Wong
Sleep-disordered breathing (SDB) is highly prevalent in the general population and has been associated with cognitive impairment in older individuals. Delirium is an acute decline in cognitive function and attention that often occurs after surgery, especially in older individuals. Several recent studies suggest an association between SDB and postoperative delirium. The aim of this systematic review is to examine the current literature on SDB, postoperative delirium, and cognitive impairment and to discuss the pathophysiology and perioperative considerations...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431378/development-of-novel-alternative-biodiesel-fuels-for-reducing-pm-emissions-and-pm-related-genotoxicity
#16
Po-Ming Yang, Chia-Chi Wang, Ying-Chi Lin, Syu-Ruei Jhang, Li-Jung Lin, Yuan-Chung Lin
This paper intend to investigate the effects of biodiesel fuel blends comprising of waste-cooking oil and butanol-diesel (B10W10-B10W40) under steady-state conditions. Both particulate organic carbon (OC) and PM including PM2.5 and PM10 significantly decreased with the increasing percentage of biodiesel fuel blends. The fuel blend of B10W40 also demonstrated the most effective function in reducing the emissions of PM10 and PM2.5 in the volume by 59.4% and 57.7%, respectively. Moreover, the emissions of nitrogen oxides decreased with the blending of B10W10-B10W40 (13...
April 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28431278/intranasal-oxytocin-does-not-modulate-jumping-to-conclusions-in-schizophrenia-potential-interactions-with-caudate-volume-and-baseline-social-functioning
#17
Fernando Caravaggio, Philip Gerretsen, Wanna Mar, Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Julia Kim, Yusuke Iwata, Raihaan Patel, M Mallar Chakravarty, Gary Remington, Ariel Graff-Guerrero, Mahesh Menon
BACKGROUND: Patients with schizophrenia (SCZ) tend to sample less information when making a decision, jumping to conclusions (JTC) without sufficient evidence. This "JTC bias" may be a trait marker of the disease and may not improve with antipsychotic treatment. We conducted a double-blind, placebo-controlled trial to test whether intranasal oxytocin could reduce JTC in stable, medicated patients with SCZ and healthy controls (HCs). We also explored whether striatal volume, clinical symptoms, and baseline social functioning (SF) was related to JTC performance...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28431242/structural-and-functional-analysis-of-a-%C3%AE-2-adrenergic-receptor-complex-with-grk5
#18
Konstantin E Komolov, Yang Du, Nguyen Minh Duc, Robin M Betz, João P G L M Rodrigues, Ryan D Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M Adams, Ron O Dror, Ka Young Chung, Brian K Kobilka, Jeffrey L Benovic
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent years, the molecular architecture of a GPCR/GRK complex remains poorly defined. We used a comprehensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), electron microscopy, mutagenesis, molecular dynamics simulations, and computational docking to analyze GRK5 interaction with the β2-adrenergic receptor (β2AR)...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431200/the-utility-of-flow-cytometry-in-differentiating-nk-t-cell-lymphoma-from-indolent-and-reactive-nk-cell-proliferations
#19
Sanjay de Mel, Jenny Bei Li, Muhammad Bilal Abid, Tiffany P L Tang, Hui Ming Tay, Wen Chang Ting, Li Mei Poon, Tae Hoon Chung, Benjamin Mow, Allison Tso, Kiat Hoe Ong, Wee Joo Chng, Te Chih Liu
BACKGROUND: The WHO defines 3 categories of NK cell malignancies; extra nodal NK/T cell lymphoma (NKTCL), aggressive NK cell leukaemia, and the provisional entity chronic lymphoproliferative disorder of NK cells (CLPD-NK). Although the flow cytometric (FC) phenotype of CLPD-NK has been described, studies on FC phenotype of NKTCL are limited. To the best of our knowledge ours is the first study to compare the phenotype of NKTCL, CLPD-NK, reactive NK lymphocytosis (RNKL), and normal NK cells using eight colour (8C) FC...
April 21, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28431184/congener-specific-disposition-of-chiral-polychlorinated-biphenyls-in-lactating-mice-and-their-offspring-implications-for-pcb-developmental-neurotoxicity
#20
Izabela Kania-Korwel, Tracy Lukasiewicz, Christopher D Barnhart, Marianna Stamou, Haeun Chung, Kevin M Kelly, Stelvio Bandiera, Pamela J Lein, Hans-Joachim Lehmler
Chiral polychlorinated biphenyl (PCB) congeners have been implicated by laboratory and epidemiological studies in PCB developmental neurotoxicity. These congeners are metabolized by cytochrome P450 (P450) enzymes to potentially neurotoxic hydroxylated metabolites (OH-PCBs). The present study explores the enantioselective disposition and toxicity of two environmentally relevant, neurotoxic PCB congeners and their OH-PCB metabolites in lactating mice and their offspring following dietary exposure of the dam. Female C57BL/6N mice (8 weeks old) were fed daily, beginning two weeks prior to conception and continuing throughout gestation and lactation, with 3...
April 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
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