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https://www.readbyqxmd.com/read/28092667/oncogenic-braf-fusions-in-mucosal-melanomas-activate-the-mapk-pathway-and-are-sensitive-to-mek-pi3k-inhibition-or-mek-cdk4-6-inhibition
#1
H S Kim, M Jung, H N Kang, H Kim, C-W Park, S-M Kim, S J Shin, S H Kim, S G Kim, E K Kim, M R Yun, Z Zheng, K Y Chung, J Greenbowe, S M Ali, T-M Kim, B C Cho
Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six PMMs underwent targeted exome sequencing of 111 cancer-associated genes. Seventy-six somatic nonsynonymous mutations in 42 genes were observed, and recurrent mutations were noted on eight genes, including TP53 (13%), NRAS (13%), SNX31 (9%), NF1 (9%), KIT (7%) and APC (7%). Mitogen-activated protein kinase (MAPK; 37%), cell cycle (20%) and phosphatidylinositol 3-kinase (PI3K)-mTOR (15%) pathways were frequently mutated...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28092638/mr-elastography-to-measure-the-effects-of-cancer-and-pathology-fixation-on-prostate-biomechanics-and-comparison-with-t-1-t-2-and-adc
#2
Deirdre M McGrath, Jenny Lee, Warren D Foltz, Navid Samavati, Theo van der Kwast, Michael A S Jewett, Peter Chung, Cynthia Ménard, Kristy K Brock
MRI is under evaluation for image-guided intervention for prostate cancer. The sensitivity and specificity of MRI parameters is determined via correlation with the gold-standard of histopathology. Whole-mount histopathology of prostatectomy specimens can be digitally registered to in vivo imaging for correlation. When biomechanical-based deformable registration is employed to account for deformation during histopathology processing, the ex vivo biomechanical properties are required. However, these properties are altered by pathology fixation, and vary with disease...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28092471/genomics-pipelines-and-data-integration-challenges-and-opportunities-in-the-research-setting
#3
Jeremy Davis-Turak, Sean M Courtney, E Starr Hazard, W Bailey Glen, Willian da Silveira, Timothy Wesselman, Larry P Harbin, Bethany J Wolf, Dongjun Chung, Gary Hardiman
The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine...
January 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28092370/api5-confers-cancer-stem-cell-like-properties-through-the-fgf2-nanog-axis
#4
K-H Song, H Cho, S Kim, H-J Lee, S J Oh, S R Woo, S-O Hong, H S Jang, K H Noh, C H Choi, J-Y Chung, S M Hewitt, J-H Kim, M Son, S-H Kim, B I Lee, H-C Park, Y-K Bae, T W Kim
Immune selection drives the evolution of tumor cells toward an immune-resistant and cancer stem cell (CSC)-like phenotype. We reported that apoptosis inhibitor-5 (API5) acts as an immune escape factor, which has a significant role in controlling immune resistance to antigen-specific T cells, but its functional association with CSC-like properties remains largely unknown. In this study, we demonstrated for the first time that API5 confers CSC-like properties, including NANOG expression, the frequency of CD44-positive cells and sphere-forming capacity...
January 16, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28091817/teratomas-of-the-cranial-vault-a-systematic-analysis-of-clinical-outcomes-stratified-by-histopathological-subtypes
#5
Carlito Lagman, Timothy T Bui, Brittany L Voth, Lawrance K Chung, David J Seo, Courtney Duong, Mark R Libowitz, Naomi E Walker, Daniel T Nagasawa, Isaac Yang
BACKGROUND: Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses: mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas. METHODS: We performed a systematic analysis of the published literature to identify studies describing patients with intracranial teratomas diagnosed with magnetic resonance imaging (MRI) and presenting definite information on histologies, therapies, and outcomes at a minimum follow-up of 2 years...
January 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28091588/high-molecular-weight-hyaluronic-acid-attenuated-matrix-metalloproteinase-1-and-3-expression-via-cd44-in-tendinopathy
#6
Po-Ting Wu, Li-Chieh Kuo, Fong-Chin Su, Shih-Yao Chen, Tai-I Hsu, Chung-Yi Li, Kuen-Jer Tsai, I-Ming Jou
Evidence indicates that hyaluronic acid (HA) mitigates tendinopathy, but the effect of molecular weight is unclear. We investigated the effects of different concentrations and different molecular weights of HA (350 kDa, 1500 kDa, and 3000 kDa) on matrix metalloproteinase (MMP)-1 and -3 expression in IL-1β-stimulated rat tenocytes, and on their dynamic expression in peritendinous effusion from patients with long head of biceps (LHB) tendinopathy after high-molecular-weight (HMW)-HA treatments. Reverse transcription PCR, real-time PCR, and ELISA were used to determine MMP-1 and -3expression...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090670/an-endoplasmic-reticulum-protein-nogo-b-facilitates-alcoholic-liver-disease-through-regulation-of-kupffer-cell-polarization
#7
Jin-Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri
Background Nogo-B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Since ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). Methods M1 and M2 phenotypes were assessed in relation to Nogo-B expression and disease severity in liver specimens from ALD patients (NCT01875211). Liver specimens from wild-type (WT) and Nogo-B knockout (KO) mice fed control or Lieber-DeCarli ethanol liquid diet (5% ethanol) for 6 weeks were analyzed for liver injury and steatosis...
January 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28090563/targeting-%C3%AE-v-integrins-in-pancreatic-fibrosis-progress-in-resolving-the-scar
#8
EDITORIAL
Chuhan Chung, Fred S Gorelick
No abstract text is available yet for this article.
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28090493/toxic-megacolon-and-interstitial-pneumonia-caused-by-cytomegalovirus-infection-in-a-pediatric-patient-with-acute-lymphoblastic-leukemia-receiving-chemotherapy
#9
Hyunseop Kwon, Hyun Hee Lee, Chung Ryul Paik, Yun-Jeong Lim, Jeong A Park
No abstract text is available yet for this article.
December 2016: Blood Research
https://www.readbyqxmd.com/read/28090487/clinical-characteristics-and-outcomes-of-varicella-zoster-virus-infection-in-children-with-hematologic-malignancies-in-the-acyclovir-era
#10
Seul-Ki Kim, Min Chae Kim, Seung Beom Han, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang, Hack-Ki Kim
BACKGROUND: Although intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported. METHODS: The medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated...
December 2016: Blood Research
https://www.readbyqxmd.com/read/28090460/efficacy-and-safety-of-dienogest-in-patients-with-endometriosis-a-single-center-observational-study-over-12-months
#11
So Yun Park, Sung Hoon Kim, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang
OBJECTIVE: To evaluate the efficacy and safety of dienogest treatment in patients who had received dienogest for 12 months or more to treat endometriosis. METHODS: We analyzed the clinical data of 188 women with endometriosis who had been treated with 2 mg of dienogest once a day for 12 months or more at a single institute. We evaluated changes in endometriosis-associated pain and endometrioma size, recurrence rate, and adverse events following dienogest administration...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28090450/quantitative-magnetic-resonance-imaging-of-the-lumbar-intervertebral-discs
#12
REVIEW
Dosik Hwang, Sewon Kim, Nirusha A Abeydeera, Sheronda Statum, Koichi Masuda, Christine B Chung, Palanan Siriwanarangsun, Won C Bae
Human lumbar spine is composed of multiple tissue components that serve to provide structural stability and proper nutrition. Conventional magnetic resonance (MR) imaging techniques have been useful for evaluation of IVD, but inadequate at imaging the discovertebral junction and ligamentous tissues due primarily to their short T2 nature. Ultrashort time to echo (UTE) MR techniques acquire sufficient MR signal from these short T2 tissues, thereby allowing direct and quantitative evaluation. This article discusses the anatomy of the lumbar spine, MR techniques available for morphologic and quantitative MR evaluation of long and short T2 tissues of the lumbar spine, considerations for T2 relaxation modeling and fitting, and existing and new techniques for spine image post-processing, focusing on segmentation...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090449/ultrashort-time-to-echo-magnetic-resonance-techniques-for-the-musculoskeletal-system
#13
REVIEW
Palanan Siriwanarangsun, Sheronda Statum, Reni Biswas, Won C Bae, Christine B Chung
Magnetic resonance (MR) imaging has been widely implemented as a non-invasive modality to investigate musculoskeletal (MSK) tissue disease, injury, and pathology. Advancements in MR sequences provide not only enhanced morphologic contrast for soft tissues, but also quantitative biochemical evaluation. Ultrashort time to echo (UTE) sequence, in particular, enables novel morphologic and quantitative evaluation of previously unseen MSK tissues. By using short minimum echo times (TE) below 1 msec, the UTE sequence can unveil short T2 properties of tissues including the deepest layers of the articular cartilage, cartilaginous endplate at the discovertebral junction, the meniscus, and the cortical bone...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090418/the-forgotten-lumbocostal-ligament-anatomical-study-with-application-to-thoracolumbar-surgery
#14
Erfanul Saker, Gabrielle G Tardieu, Fernando Alonso, Beom Sun Chung, Christian Fisahn, Marios Loukas, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Most ligaments of the human body have been well studied. However, the lumbocostal ligament has received little attention in the extant medical literature and, to our knowledge, has not undergone anatomical study. Therefore, the present study was performed to better characterize this structure's anatomy and relationships. METHODS: In the prone position, 10 adult cadavers underwent dissection of their lumbocostal ligaments. All specimens were unembalmed and had no history of surgery to the spine...
December 11, 2016: Curēus
https://www.readbyqxmd.com/read/28090095/academic-freedom-should-be-redefined-point-and-counterpoint
#15
Tonja M Woods, W Renee' Acosta, Eunice P Chung, Arthur G Cox, George A Garcia, Jamie Ridley Klucken, Marie Chisholm-Burns
As part of the 2014-15 Academic Leadership Fellows Program, the cohort teams presented debates on topics relevant to academic pharmacy at a public forum during the 2015 American Association of Colleges of Pharmacy Interim Meeting. The topic of one of the debates was "Academic Freedom Should Be Redefined." The "point" of the debate focused on important issues such as the fundamental definition of academic freedom as it was written in the 1940 American Association of University Professors' Statement and the need for redefinition as a consequence of many misunderstandings and misinterpretations that have arisen over time...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089890/single-chromosome-gains-commonly-function-as-tumor-suppressors
#16
Jason M Sheltzer, Julie H Ko, John M Replogle, Nicole C Habibe Burgos, Erica S Chung, Colleen M Meehl, Nicole M Sayles, Verena Passerini, Zuzana Storchova, Angelika Amon
Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as xenografts, relative to genetically matched euploid cells. Moreover, the activation of several oncogenic pathways failed to alleviate the fitness defect induced by aneuploidy. However, following prolonged growth, trisomic cells acquired additional chromosomal alterations that were largely absent from their euploid counterparts and that correlated with improved fitness...
December 29, 2016: Cancer Cell
https://www.readbyqxmd.com/read/28089863/prevention-of-thrombosis-in-hypercoagulable-patients-undergoing-microsurgery-a-novel-anticoagulation-protocol
#17
Jonas A Nelson, Cyndi U Chung, Andrew R Bauder, Liza C Wu
BACKGROUND: Hypercoagulable conditions are often considered relative contraindications to free flap reconstruction. This paper presents and critically examines a novel anticoagulation regimen developed to address this disease state. METHODS: Hypercoagulable patients who underwent free tissue transfer between 2007 and 2015 were identified. From 2011, all such patients were subjected to a novel anticoagulation protocol involving an intravenous bolus of 2000 U of unfractionated heparin prior to microvascular pedicle anastomosis, followed by a heparin infusion at 500 U/h, which was postoperatively increased to therapeutic levels...
December 18, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28089850/impact-of-radiofrequency-ablation-treatment-of-barrett-s-esophagus-on-esophageal-adenocarcinoma-a-comparative-modeling-analysis
#18
Sonja Kroep, Curtis R Heberle, Kit Curtius, Chung Yin Kong, Iris Lansdorp-Vogelaar, Ayman Ali, W Asher Wolf, Nicholas J Shaheen, Stuart J Spechler, Joel H Rubenstein, Norman S Nishioka, Stephen J Meltzer, William D Hazelton, Marjolein van Ballegooijen, Angela C Tramontano, G Scott Gazelle, E Georg Luebeck, John M Inadomi, Chin Hur
No abstract text is available yet for this article.
January 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28089748/bioaccumulation-of-lead-and-non-specific-immune-responses-in-white-shrimp-litopenaeus-vannamei-to-pb-exposure
#19
Yu-Sheng Wu, Shih-Ling Huang, Hsin-Chieh Chung, Fan-Hua Nan
In this study, we investigated organ accumulation and nonspecific immune response in white shrimp (Litopenaeus vannamei) that were exposed to various concentrations of lead (Pb) solution. The concentrations of Pb in the hepatopancreas, haemolymph, and muscle were measured moreover the total heamocyte count, phenoloxidase activity, O2(-) and physiological factors such as glutamic oxaloacetate transaminase (GOT), glutamic pyruvic transaminase (GPT), and haemolymph glucose were detected. The results showed that the hepatopancreas was the main organ of accumulation of Pb in white shrimp and the cumulative concentration of each organ was positively correlated with the experimental Pb concentration and immersion time...
January 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28089588/discovery-of-a-novel-series-of-n-hydroxypyridone-derivatives-protecting-astrocytes-against-hydrogen-peroxide-induced-toxicity-via-improved-mitochondrial-functionality
#20
Sarbjit Singh, Ja-Il Goo, Hyojin Noh, Sung Jae Lee, Myoung Woo Kim, Hyejun Park, Hitesh B Jalani, Kyeong Lee, Chunsook Kim, Won-Ki Kim, Chung Ju, Yongseok Choi
Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives...
January 3, 2017: Bioorganic & Medicinal Chemistry
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