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Alonzo T Folger, Emily A Eismann, Nicole B Stephenson, Robert A Shapiro, Maurizio Macaluso, Maggie E Brownrigg, Robert J Gillespie
OBJECTIVES: The study objective was to determine if maternal and paternal exposure to adverse childhood experiences (ACEs) have a significant association with negative offspring development at 24 months of age in a suburban pediatric primary care population. METHODS: A retrospective cohort study was conducted of 311 mother-child and 122 father-child dyads who attended a large pediatric primary care practice. Children were born from October 2012 to June 2014, and data were collected at the 2-, 4-, and 24-month well-child visits...
March 21, 2018: Pediatrics
Karmel W Choi, Renate Houts, Louise Arseneault, Carmine Pariante, Kathleen J Sikkema, Terrie E Moffitt
Mothers who have experienced childhood maltreatment are more likely to have children also exposed to maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely to this transmission, but timing effects have not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 children in the Environmental Risk Longitudinal Twin Study, we tested the mediating role of postpartum depression between maternal childhood maltreatment and a cascade of negative child outcomes, specifically child exposure to maltreatment, internalizing symptoms, and externalizing symptoms: (a) adjusting for later maternal depression, (b) comparing across sex differences, and (c) examining the relative role of maltreatment subtypes...
March 22, 2018: Development and Psychopathology
Na Liu, Yuping Cao, Huifen Qiao, Hui Ma, Jijun Li, Xingguang Luo, Chiang-Shan Ray Li, Yalin Zhang, Ning Zhang
We aimed to compare traumatic experiences among the groups of perpetrators with or without violent pedigree, and establish a structural model of posttraumatic stress disorder (PTSD) symptoms as mediators of traumatic experiences and severe intrafamilial physical violence among Chinese male perpetrators. A cross-sectional survey and a face-to-face interview were conducted to examine intimate partner violence (IPV) perpetration and violent pedigree, childhood maltreatment, other traumatic events, PTSD symptoms, and severe intrafamilial physical violence in a community sample of 229 abusive men and 303 controlled men in China...
March 1, 2018: Journal of Interpersonal Violence
Calvin K Lee, Jaime de Anda, Amy E Baker, Rachel R Bennett, Yun Luo, Ernest Y Lee, Joshua A Keefe, Joshua S Helali, Jie Ma, Kun Zhao, Ramin Golestanian, George A O'Toole, Gerard C L Wong
Using multigenerational, single-cell tracking we explore the earliest events of biofilm formation by Pseudomonas aeruginosa During initial stages of surface engagement (≤20 h), the surface cell population of this microbe comprises overwhelmingly cells that attach poorly (∼95% stay <30 s, well below the ∼1-h division time) with little increase in surface population. If we harvest cells previously exposed to a surface and direct them to a virgin surface, we find that these surface-exposed cells and their descendants attach strongly and then rapidly increase the surface cell population...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Valeria Bulgach, Cecilia Zunana, Paula Califano, M Susana Rodríguez, Roberto Mato
INTRODUCTION: Teenage pregnancy is highly prevalent. OBJECTIVE: To describe several features of a group of adolescent mothers admitted along with their children in a high complexity pediatric hospital and to explore the difference between those in early-mid and late adolescence. METHODS: Observational, transversal study, through a survey including socio-demographic variables, information about their pregnancy, delivery and their newborns. RESULTS: We included 227 mothers, 100 were aged < 17 years old and 127 were aged from 17 to 19 years and 11 months...
April 1, 2018: Archivos Argentinos de Pediatría
David Matthew Doyle, Pam Factor-Litvak, Bruce G Link
OBJECTIVE: The aim of the present study was to test a life course model in which racial disparities in physical health between Caucasian and African Americans are driven by disparities in close relationship functioning. This model also examined relative evidence for intergenerational transmission of relationship functioning and ongoing exposure to prejudice and discrimination as two pathways that might shape adult relationship functioning. METHOD: A sample of 523 Caucasian and African American men and women were prospectively tracked from a birth cohort initiated in the 1960s...
February 3, 2018: Social Science & Medicine
Grace S Chng, Dongdong Li, Chi Meng Chu, Tabitha Ong, Felicia Lim
Children who enter the child protection system often have complex family problems and have experienced early adverse experiences. Using latent class analysis, this study aimed to identify family classes of child protection cases in Singapore, to ascertain the prevalence of these family classes, and to test the association of family class membership to subsequent recurrence of harm. A sample of 440 cases who entered the Child Protective Service in Singapore was analyzed based on eight familial factors on the household and caregiver levels...
March 13, 2018: Child Abuse & Neglect
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Edward W Pietryk, Kiristin Clement, Marwa Elnagheeb, Ryan Kuster, Kayla Kilpatrick, Michael I Love, Folami Y Ideraabdullah
In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of VIN vs. M2 (metabolite with greater antiandrogenic activity) and wild-type C57BL/6 (B6) mice vs. mice carrying mutations at the previously reported VIN-responsive H19/Igf2 locus. First generation offspring from VIN-treated 8nrCG mutant dams exhibited increased body weight and decreased sperm ICR methylation...
March 10, 2018: Reproductive Toxicology
Sarah J Hahn, Jennifer M Kinney, Jennifer Heston
Service-learning is a widely used pedagogical practice that integrates community involvement and civic engagement into the classroom. Benefits of service-learning in gerontology include an increased sense of personal growth, greater knowledge of aging, and enhanced interest in aging-related careers. However, relatively little research has specifically explored the challenges associated with intergenerational service-learning. A focus group documented the experiences of 19 students who were required to participate in at least 20 hours of intergenerational service-learning for an introductory gerontology course...
March 13, 2018: Gerontology & Geriatrics Education
Courtney Rogers, Joy Johnson, Brianne Nueslein, David Edmunds, Rupa S Valdez
As chronic conditions are on the rise in the USA, management initiatives outside of the inpatient setting should be explored to reduce associated cost and access disparities. Chronic conditions disproportionately affect African American public housing residents due to the effects of historical marginalization on the manifestation of economic and social problems exacerbating health disparities and outcomes. Informed by participatory research action tenets, this study focused on identifying the challenges to management of chronic conditions and developing community-envisioned initiatives to address these challenges in a predominantly African American public housing community...
March 12, 2018: Journal of Racial and Ethnic Health Disparities
Christoph Rehmann-Sutter
Do we have a moral obligation to genetically cure embryos rather than selecting between them? Such an obligation would be an ethical argument for human germline gene editing (hGGE) to avoid the inheritance of genetic conditions instead of using pre-implantation genetic diagnosis (PGD). In this article, the intuition that we do have such a moral obligation is critically evaluated. The article first develops a theoretical framework for discussing the ethical questions of hGGE. This framework is based on an exploration of the phenomenology of the germline, from both biological and philosophical points of view...
April 2018: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
Attachment is transmitted from one generation to the next. Adult attachment has been shown to predict the security or insecurity of children's attachment relationship with their parents. In search for the mechanism of intergenerational transmission of attachment sensitive parenting has been the main focus of research during the past four decades. Meta-analytic work confirmed the role of sensitive parenting, but a large explanatory gap remains to be explained. Parental mentalization has not yet fulfilled its promise as a bridge across the transmission gap...
February 27, 2018: Current Opinion in Psychology
Bethany M Breck, Cory B Dennis, Skye N Leedahl
Reverse mentoring is a means to address the social work Grand Challenge of social isolation. Among older adults, reverse mentoring can improve social connection by increasing the digital competence of older adults so they can use technology for social benefit, and by facilitating intergenerational connections with young adult mentors. In this paper, reverse mentoring is examined within an intergenerational program that serves older adults and utilizes the native technological knowledge and skills of young adults who mentor older adult participants...
March 12, 2018: Journal of Gerontological Social Work
Marco Tosi, Emily Grundy
OBJECTIVE: We investigate the association between parent-child contact frequency and changes in older parents' depressive symptoms in Bulgaria, Georgia and Russia. These are countries in which societal transformations may mean that psychological feelings of security engendered by having children in close contact may have particularly important implications for the mental health of older parents. METHODS: We analysed data from two waves of the Generation and Gender Surveys conducted three years apart and took account of relationships with more than one child...
March 12, 2018: Aging & Mental Health
Stephanie M Merwin, Chelsey Barrios, Victoria C Smith, Edward P Lemay, Lea R Dougherty
This study examined the impact of parent-child attunement of morning cortisol on parenting and child outcomes in dyads with and without parental depression. Participants included 142 parent-child dyads (3-5 years-old) who provided morning cortisol samples at Wave 1, and 98 dyads returned for the 3-year follow-up at Wave 2. Results indicated that for parents with a history of depression and for female children, stronger attunement predicted increases in parental hostility from Wave 1 to Wave 2. For females only, stronger attunement was related to children's depressive symptoms at Wave 1 and Wave 2...
March 12, 2018: Developmental Psychobiology
Anna Kovalchuk, Yaroslav Ilnytskyy, Rafal Woycicki, Rocio Rodriguez-Juarez, Gerlinde A S Metz, Olga Kovalchuk
Recent advances in cancer treatments have led to significant increases in cure rates. Most cancer patients are treated with various cytotoxic chemotherapy regimens. These treatment modalities are mutagenic and genotoxic and cause a wide array of late-occurring health problems, and even exert a deleterious influence on future offspring. The adverse effects from exposed parents on offspring are referred to as transgenerational effects, and currently little is known about chemotherapy-induced transgenerational effects...
February 9, 2018: Oncotarget
Ryan J Petteway, Payam Sheikhattari, Fernando Wagner
The growing prominence of community-based participatory research (CBPR) presents as an opportunity to improve tobacco-related intervention efforts. CBPR collaborations for tobacco/health, however, typically engage only adults, thus affording only a partial understanding of community context as related to tobacco. This is problematic given evidence around age of tobacco use initiation and the influence of local tobacco environments on youth. The CEASE and Resist youth photovoice project was developed as part of the Communities Engaged and Advocating for a Smoke-free Environment (CEASE) CBPR collaboration in Southwest Baltimore...
March 1, 2018: Health Promotion Practice
Xiaoyu Yu, Oleg N Reva
Modern phylogenetic studies may benefit from the analysis of complete genome sequences of various microorganisms. Evolutionary inferences based on genome-scale analysis are believed to be more accurate than the gene-based alternative. However, the computational complexity of current phylogenomic procedures, inappropriateness of standard phylogenetic tools to process genome-wide data, and lack of reliable substitution models which correlates with alignment-free phylogenomic approaches deter microbiologists from using these opportunities...
2018: Evolutionary Bioinformatics Online
Jerica M Berge, Megan R Winkler, Nicole Larson, Jonathan Miller, Ann F Haynos, Dianne Neumark-Sztainer
BACKGROUND: Although previous cross-sectional research has revealed potential harmful outcomes associated with parent encouragement to diet, it is unclear whether these effects are long lasting and whether they are transmitted to the next generation. The main aim of the current study was to examine longitudinal associations between exposure to parent encouragement to diet in adolescence and weight-related and emotional health outcomes in adulthood and to examine whether intergenerational transmission of encouragement to diet occurs...
March 6, 2018: Pediatrics
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