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https://www.readbyqxmd.com/read/27889598/association-between-antipsychotic-drug-use-and-cataracts-in-patients-with-bipolar-disorder-a-population-based-nested-case-control-study
#1
Che-Sheng Chu, Po-Han Chou, Yi-Huei Chen, Min-Wei Huang, Min-Yen Hsu, Tsuo-Hung Lan, Ching-Heng Lin
BACKGROUND: No previous study has focused on the association between use of antipsychotic drugs and the development of cataracts in patients with bipolar disorder (BD); hence, we aimed to examine this association in the present study. METHODS: We conducted a retrospective nested case-control study using data from the National Health Insurance Database of Taiwan between 2000 and 2011. A total of 3292 BD patients, 1684 with cataracts and 1608 controls matched for age, sex, and index date, were included...
November 19, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27827293/vitamin-d-deficiency-behavioral-atypicality-anxiety-and-depression-in-children-with-chromosome-22q11-2-deletion-syndrome
#2
L Kelley, A F P Sanders, E A Beaton
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a complex developmental disorder with serious medical, cognitive and emotional symptoms across the lifespan. This genetic deletion also imparts a lifetime risk for developing schizophrenia that is 25-30 times that of the general population. The origin of this risk is multifactorial and may include dysregulation of the stress response and immunological systems in relation to brain development. Vitamin D is involved in brain development and neuroprotection, gene transcription, immunological regulation and influences neuronal signal transduction...
December 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27816667/correlation-between-brain-damage-associated-biomarkers-and-medication-in-psychiatric-inpatients-a-cross-sectional-study
#3
Madoka Yoshida, Tetsuto Kanzaki, Mutsumi Mizoi, Mizuho Nakamura, Takeshi Uemura, Seisuke Mimori, Yoriyasu Uju, Keisuke Sekine, Yukihiro Ishii, Taro Yoshimi, Reiko Yasui, Asuka Yasukawa, Mamoru Sato, Seiko Okamoto, Tetsuya Hisaoka, Masafumi Miura, Shun Kusanishi, Kanako Murakami, Chieko Nakano, Yasuhiko Mizuta, Shunichi Mishima, Tatsuro Hayakawa, Kazumi Tsukada, Keiko Kashiwagi, Kazuei Igarashi
BACKGROUND: We clarified the correlation between brain damage, associated biomarkers and medication in psychiatric patients, because patients with schizophrenia have an increased risk of stroke. METHODS: The cross-sectional study was performed from January 2013 to December 2015. Study participants were 96 hospitalized patients (41 men and 55 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan...
November 3, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27801896/alterations-in-amygdala-prefrontal-circuits-in-infants-exposed-to-prenatal-maternal-depression
#4
J Posner, J Cha, A K Roy, B S Peterson, R Bansal, H C Gustafsson, E Raffanello, J Gingrich, C Monk
Prenatal exposure to maternal depression is common and puts offspring at risk for developing a range of neuropsychiatric disorders. Despite its prevalence and adverse associations, neurobiological processes by which prenatal maternal depression (PMD) confers risk remain poorly understood. Maternal mood and fetal behavior were assessed between 34 and 37 gestational weeks. Using resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI, we examined functional and structural connectivity within amygdala-prefrontal circuits in 64 infants (mean age=5...
November 1, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27795456/marketing-masked-depression-physicians-pharmaceutical-firms-and-the-redefinition-of-mood-disorders-in-the-1960s-and-1970s
#5
Lucie Gerber, Jean-Paul Gaudillière
This article investigates the redefinition of depression that took place in the early 1970s. Well before the introduction of the third edition of the Diagnostic and Statistical Manual of Mental Disorders, this rather rare and severe psychiatric disorder hitherto treated in asylums was transformed into a widespread mild mood disorder to be handled by general practitioners. Basing itself on the archives of the Swiss firm Ciba-Geigy, the article investigates the role of the pharmaceutical industry in organizing this shift, with particular attention paid to research and scientific marketing...
2016: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/27759189/prescribing-patterns-of-psychotropic-medications-and-clinical-features-in-patients-with-major-depressive-disorder-with-and-without-comorbid-dysthymia-in-china
#6
Yuan Feng, Sha Sha, Chen Hu, Gang Wang, Gabor S Ungvari, Helen F K Chiu, Chee H Ng, Tian-Mei Si, Da-Fang Chen, Yi-Ru Fang, Zheng Lu, Hai-Chen Yang, Jian Hu, Zhi-Yu Chen, Yi Huang, Jing Sun, Xiao-Ping Wang, Hui-Chun Li, Jin-Bei Zhang, Yu-Tao Xiang
INTRODUCTION: Little has been reported about the demographic and clinical features of major depressive disorder (MDD) with comorbid dysthymia in Chinese patients. This study examined the frequency of comorbid dysthymia in Chinese MDD patients together with the demographic and clinical correlates and prescribing patterns of psychotropic drugs. METHODS: Consecutively collected sample of 1178 patients with MDD were examined in 13 major psychiatric hospitals in China...
October 19, 2016: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/27727180/do-atypical-antipsychotics-have-antisuicidal-effects-a-hypothesis-generating-overview
#7
Maurizio Pompili, Ross J Baldessarini, Alberto Forte, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi
Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general...
October 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27663798/risk-and-efficacy-in-cognitive-functions-in-bipolar-disorder-ii-with-atypical-antipsychotic-augmentation
#8
Francesco Franza
BD-II has been consistently associated with cognitive dysfunction across a broad range of cognitive domains. Atypical antipsychotic drugs, or SGAs are effective antipsychotics in these diseases, often in combination with antidepressants and mood stabilizers. Data on the possible effect of antipsychotics on neuro-cognition are rare and conflicting. The main objective of our study was to assess the effectiveness and possible risks to cognitive function in a group of inpatients affected by BD-II. Forty-five inpatients with Bipolar II Disorder (DSM-5) were included in a two-year observational study...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27662894/evidence-based-treatments-for-youths-with-severely-dysregulated-mood-a-qualitative-systematic-review-of-trials-for-smd-and-dmdd
#9
Xavier Benarous, Angèle Consoli, Jean-Marc Guilé, Sébastien Garny de La Rivière, David Cohen, Bertrand Olliac
The aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH's criteria for Severe Mood Dysregulation (SMD) or the DSM-5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD)...
September 23, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27591453/topiramate-for-acute-affective-episodes-in-bipolar-disorder-in-adults
#10
Katie Pigott, Ilaria Galizia, Kamini Vasudev, Stuart Watson, John Geddes, Allan H Young
BACKGROUND: Bipolar disorder is a common recurrent illness with high levels of chronicity. Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. This is an update of a previous Cochrane review (last published 2006) on the role of topiramate in bipolar disorder. OBJECTIVES: To assess the effects of topiramate for acute mood episodes in bipolar disorder in adults compared to placebo, alternative pharmacological treatment, and combination pharmacological treatment as measured by treatment of symptoms on specific rating scales for individual episodes...
September 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27578495/impaired-frontal-limbic-white-matter-maturation-in-children-at-risk-for-major-depression
#11
Yuwen Hung, Zeynep M Saygin, Joseph Biederman, Dina Hirshfeld-Becker, Mai Uchida, Oliver Doehrmann, Michelle Han, Xiaoqian J Chai, Tara Kenworthy, Pavel Yarmak, Schuyler L Gaillard, Susan Whitfield-Gabrieli, John D E Gabrieli
Depression is among the most common neuropsychiatric disorders. It remains unclear whether brain abnormalities associated with depression reflect the pathological state of the disease or neurobiological traits predisposing individuals to depression. Parental history of depression is a risk factor that more than triples the risk of depression. We compared white matter (WM) microstructure cross-sectionally in 40 children ages 8-14 with versus without parental history of depression (At-Risk vs. Control). There were significant differences in age-related changes of fractional anisotropy (FA) between the groups, localized in the anterior fronto-limbic WM pathways, including the anterior cingulum and the genu of the corpus callosum...
August 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27571656/overweight-and-the-use-of-psychiatric-drugs-in-patients-with-mental-disorders-attended-at-psychosocial-care-center-teresina-piau%C3%A3-brazil
#12
Marize Melo Dos Santos, Sarah De Melo Rocha Cabral, Márcio Denis Medeiros Mascarenhas, Renato Mendes Santos, Juliana Maria Libório Eulálio
INTRODUCTION: Psychopharmacology brought numerous benefits to people with mental disorders, although undesirable side effects have arisen, including weight gain. OBJECTIVE: Identify the overweight frequency in individuals with mental disorders and its relation with the use of psychiatric drugs.   MATERIAL AND METHODS: Cross-sectional study with patients with mental disorders of both sexes, older than 18 years. Body Mass Index (BMI) used to diagnose overweight (BMI > 25 kg/m2)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27542851/suicidal-behavior-in-mood-disorders-response-to-pharmacological-treatment
#13
REVIEW
Leonardo Tondo, Ross J Baldessarini
Suicidal behavior is strongly associated with depression, especially if accompanied by behavioral activation, dysphoria, or agitation. It may respond to some treatments, but the design of scientifically sound, ethical trials to test for therapeutic effects on suicidal behavior is highly challenging. In bipolar disorder, and possibly also unipolar major depression, an underprescribed medical intervention with substantial evidence of preventive effects on suicidal behavior is long-term treatment with lithium...
September 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27525148/clozapine-can-be-the-good-option-in-resistant-mania
#14
S M Yasir Arafat, S M Atikur Rahman, Md Maruful Haque, Mohsin Ali Shah, Sultana Algin, Jhunu Shamsun Nahar
Bipolar mood disorder is a mental disorder with a lifetime prevalence rate of about 1% in the general population and there are still a proportion of individuals who suffer from bipolar mood disorders that are resistant to standard treatment. Reporting clozapine responsive mania that was not responding to two previous consecutive atypical antipsychotics and one typical antipsychotic was aimed at. A 17-year-old male manic patient was admitted into the psychiatry inpatient department and was nonresponsive to Risperidone 12 mg daily for 4 weeks, Olanzapine 30 mg daily for 3 weeks, and Haloperidol 30 mg daily for 3 weeks, along with valproate preparation 1500 mg daily...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/27487259/effects-of-switching-to-aripiprazole-from-current-atypical-antipsychotics-on-subsyndromal-symptoms-and-tolerability-in-patients-with-bipolar-disorder
#15
Young Sup Woo, Won-Myong Bahk, Young-Min Park, Sangkeun Chung, Bo-Hyun Yoon, Seunghee Won, Jeong Goo Lee, Hwang-Bin Lee, Won Kim, Jong-Hyun Jeong, Kwanghun Lee, Moon-Doo Kim
We evaluated the effectiveness of aripiprazole among bipolar patients who had switched to this medication as a result of difficulty maintaining on their prestudy atypical antipsychotics (AAPs) because of subsyndromal mood symptoms or intolerance. This study included 77 bipolar patients who were in syndromal remission with an AAP as monotherapy or with an AAP combined with a mood stabilizer(s) who needed to switch from their present AAP because of subsyndromal symptoms or intolerance. At 24 weeks after switching to aripiprazole, the remission rates on the Montgomery-Åsberg Depression Rating Scale (MADRS) and on both the MADRS and the Young Mania Rating Scale were increased significantly in the full sample and in the inefficacy subgroup...
September 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27450632/familial-aggregation-and-heritability-of-the-melancholic-and-atypical-subtypes-of-depression
#16
Femke Lamers, Lihong Cui, Ian B Hickie, Catherine Roca, Rodrigo Machado-Vieira, Carlos A Zarate, Kathleen R Merikangas
BACKGROUND: The heterogeneity of mood disorders has been a challenge to our understanding of their underlying biologic and genetic pathways. This report examines the specificity of the familial aggregation of atypical and melancholic subtypes of depression and their clinical correlates in a large community based family study of affective spectrum disorders. METHODS: The sample includes 457 probands and their directly interviewed adult first degree relatives from the National Institute of Mental Health (NIMH) Family Study of Affective Spectrum Disorder...
November 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27362381/antidepressant-antipsychotic-and-hallucinogen-drugs-for-the-treatment-of-psychiatric-disorders-a-convergence-at-the-serotonin-2a-receptor
#17
Robert H Howland
Antidepressant, atypical antipsychotic, and hallucinogen drugs mediate their actions in part by interactions with the serotonin-2A (5HT2A) receptor. Serotonergic hallucinogen drugs, such as psilocybin, bind most potently as agonists at the 5HT2A receptor, producing profound changes in perception, mood, and cognition. Some of these drugs have been or are currently being investigated in small Phase 2 studies for depression, alcoholism, smoking cessation, anxiety, and posttraumatic stress disorder. However, unlike the synergistic effects of combining antidepressant and atypical antipsychotic drugs, the potential therapeutic effects of hallucinogen drugs may be attenuated by the concurrent use of these medications because antidepressant and atypical antipsychotic drugs desensitize and/or down-regulate 5HT2A receptors...
July 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27294270/-clinical-diagnosis-and-drug-therapy-of-elderly-patients-with-schizophrenia-a-restrospective-analysis-of-data-in-a-department-of-old-age-psychiatry
#18
Christian Jagsch, Gabriele Dietmaier, Maximilian Jagsch, Martin Kurz
BACKGROUND: The objective of this study was to survey the consistency of the clinical diagnostics and the psychopharmacological treatment of schizophrenia and delusional disorders suffered by older persons. A further aspect was to record significant clinical differences and also similarities between the patient groups in care, matching with the criteria of ICD 10 for schizophrenia (F20), persistent delusional disorders (F22) and schizoaffective disorder (F25). METHODS: Retrospective analysis with reference to the manually and electronically recorded patient medical records of an acute case care ward for geriatric psychiatry and psychotherapy...
June 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/27274384/pharmacotherapy-of-acute-bipolar-depression-in-adults-an-evidence-based-approach
#19
REVIEW
Ather Muneer
In the majority of cases of bipolar disorder, manic episodes are usually brief and typically responsive to currently available psychopharmacological agents. In contrast, depressive manifestations are more prevalent and persistent, and can present as major depressive/mixed episodes or residual interepisode symptoms. The depressive phase is often associated with other neuropsychiatric conditions, such as anxiety spectrum disorders, substance use disorders, stressor-related disorders, and eating disorders. It is viewed as a systemic disease with associated ailments such as metabolic syndrome, diabetes mellitus, and cardiovascular disease...
May 2016: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/27244871/-antidepressant-resistant-depression-and-the-bipolar-spectrum-diagnostic-and-therapeutic-considerations
#20
REVIEW
Zoltán Rihmer, Xénia Gonda, Annamária Rihmer, Péter Döme
According to the results of epidemiological studies mood disorders with unipolar (major and minor depressive disorder; dysthymia) or bipolar features are among the most prevalent psychiatric disorders. These disorders with their frequent comorbidities (alcohol and/or drug use disorders, smoking, suicide, cardiovascular disorders) pose great public health challenge and cause substantial individual and familar burdens as well. Since SSRIs and other new antidepressant agents entered the market the possibilities to treat depression improved substantially but 25-35 percent of major depressives do not respond even to the second antidepressant trial but the rate of patients who are resistant after the third and fourth adequate antidepressant trial are around only 15-25 and 10 percent, respectively...
2016: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
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