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https://www.readbyqxmd.com/read/29241292/the-in-situ-enzymatic-screening-ises-approach-to-reaction-discovery-and-catalyst-identification
#1
Robert A Swyka, David B Berkowitz
The importance of discovering new chemical transformations and/or optimizing catalytic combinations has led to a flurry of activity in reaction screening. The in situ enzymatic screening (ISES) approach described here utilizes biological tools (enzymes/cofactors) to advance chemistry. The protocol interfaces an organic reaction layer with an adjacent aqueous layer containing reporting enzymes that act upon the organic reaction product, giving rise to a spectroscopic signal. ISES allows the experimentalist to rapidly glean information on the relative rates of a set of parallel organic/organometallic reactions under investigation, without the need to quench the reactions or draw aliquots...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29241142/unmet-needs-burden-of-treatment-and-patient-engagement-in-multiple-sclerosis-a-combined-perspective-from-the-ms-in-the-21st-century-steering-group
#2
Peter Rieckmann, Diego Centonze, Irina Elovaara, Gavin Giovannoni, Eva Havrdová, Jurg Kesselring, Gisela Kobelt, Dawn Langdon, Sarah A Morrow, Celia Oreja-Guevara, Sven Schippling, Christoph Thalheim, Heidi Thompson, Patrick Vermersch, Karen Aston, Birgit Bauer, Christy Demory, Maria Paz Giambastiani, Jana Hlavacova, Jocelyne Nouvet-Gire, George Pepper, Maija Pontaga, Emma Rogan, Chrystal Rogalski, Pieter van Galen, Ali-Frédéric Ben-Amor
BACKGROUND: Patient engagement is vital in multiple sclerosis (MS) in order to optimise outcomes for patients, society and healthcare systems. It is essential to involve all stakeholders in potential solutions, working in a multidisciplinary way to ensure that people with MS (PwMS) are included in shared decision-making and disease management. To start this process, a collaborative, open environment between PwMS and healthcare professionals (HCPs) is required so that similarities and disparities in the perception of key areas in patient care and unmet needs can be identified...
November 21, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29241095/mathematical-modeling-approaches-to-describe-the-dynamics-of-protein-adsorption-at-solid-interfaces
#3
REVIEW
Jinku Kim
Protein adsorption on solid surfaces play a crucial role in many biological applications. While extensive experimental studies have revealed the dynamics of protein adsorption in detail using newly developed experimental techniques, mathematical modeling approaches provide illustrative insight of such complex processes, which are often difficult to describe experimentally. To advance our understanding of dynamic protein behaviors at interfaces between proteins and solid surfaces, there are needs for additional information about such complex phenomena, especially conformational changes in protein mixture system...
December 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29240926/exocet-exonuclease-in-vitro-assembly-combined-with-recet-recombination-for-highly-efficient-direct-dna-cloning-from-complex-genomes
#4
Hailong Wang, Zhen Li, Ruonan Jia, Jia Yin, Aiying Li, Liqiu Xia, Yulong Yin, Rolf Müller, Jun Fu, A Francis Stewart, Youming Zhang
The exponentially increasing volumes of DNA sequence data highlight the need for new DNA cloning methods to explore the new information. Here, we describe 'ExoCET' (Exonuclease Combined with RecET recombination) to directly clone any chosen region from bacterial and mammalian genomes with nucleotide precision into operational plasmids. ExoCET combines in vitro exonuclease and annealing with the remarkable capacity of full length RecET homologous recombination (HR) to retrieve specified regions from genomic DNA preparations...
December 12, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29240907/primary-care-for-refugees-and-newly-arrived-migrants-in-europe-a-qualitative-study-on-health-needs-barriers-and-wishes
#5
Tessa van Loenen, Maria van den Muijsenbergh, Marrigje Hofmeester, Christopher Dowrick, Nadja van Ginneken, Enkeleint Aggelos Mechili, Agapi Angelaki, Dean Ajdukovic, Helena Bakic, Danica Rotar Pavlic, Erika Zelko, Kathryn Hoffmann, Elena Jirovsky, Elisabeth Sophie Mayrhuber, Michel Dückers, Trudy Mooren, Juul Gouweloos-Trines, László Kolozsvári, Imre Rurik, Christos Lionis
Background: In order to provide effective primary care for refugees and to develop interventions tailored to them, we must know their needs. Little is known of the health needs and experiences of recently arrived refugees and other migrants throughout their journey through Europe. We aimed to gain insight into their health needs, barriers in access and wishes regarding primary health care. Methods: In the spring of 2016, we conducted a qualitative, comparative case study in seven EU countries in a centre of first arrival, two transit centres, two intermediate-stay centres and two longer-stay centres using a Participatory Learning and Action research methodology...
December 12, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29240899/patient-perceptions-of-receiving-test-results-via-online-portals-a-mixed-methods-study
#6
Traber D Giardina, Jessica Baldwin, Daniel T Nystrom, Dean F Sittig, Hardeep Singh
Objective: Online portals provide patients with access to their test results, but it is unknown how patients use these tools to manage results and what information is available to promote understanding. We conducted a mixed-methods study to explore patients' experiences and preferences when accessing their test results via portals. Materials and Methods: We conducted 95 interviews (13 semistructured and 82 structured) with adults who viewed a test result in their portal between April 2015 and September 2016 at 4 large outpatient clinics in Houston, Texas...
December 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29240835/scientific-research-on-animal-biodiversity-is-systematically-biased-towards-vertebrates-and-temperate-regions
#7
Mark A Titley, Jake L Snaddon, Edgar C Turner
Over the last 25 years, research on biodiversity has expanded dramatically, fuelled by increasing threats to the natural world. However, the number of published studies is heavily weighted towards certain taxa, perhaps influencing conservation awareness of and funding for less-popular groups. Few studies have systematically quantified these biases, although information on this topic is important for informing future research and conservation priorities. We investigated: i) which animal taxa are being studied; ii) if any taxonomic biases are the same in temperate and tropical regions; iii) whether the taxon studied is named in the title of papers on biodiversity, perhaps reflecting a perception of what biodiversity is; iv) the geographical distribution of biodiversity research, compared with the distribution of biodiversity and threatened species; and v) the geographical distribution of authors' countries of origin...
2017: PloS One
https://www.readbyqxmd.com/read/29240798/the-cost-of-comorbidities-in-treatment-for-hiv-aids-in-california
#8
David S Zingmond, Kodi B Arfer, Jennifer L Gildner, Arleen A Leibowitz
BACKGROUND: Antiretroviral therapy has increased longevity for people living with HIV (PLWH). As a result, PLWH increasingly experience the common diseases of aging and the resources needed to manage these comorbidities are increasing. This paper characterizes the number and types of comorbidities diagnosed among PLWH covered by Medicare and examines how non-HIV comorbidities relate to outpatient, inpatient, and pharmaceutical expenditures. METHODS: The study examined Medicare expenditures for 9767 HIV-positive Californians enrolled in Medicare in 2010 (7208 persons dually covered by Medicare and Medicaid and 2559 with Medicare only)...
2017: PloS One
https://www.readbyqxmd.com/read/29240786/time-trend-analysis-2009-2016-of-antimicrobial-susceptibility-in-neisseria-gonorrhoeae-isolated-in-italy-following-the-introduction-of-the-combined-antimicrobial-therapy
#9
Paola Stefanelli, Maria Fenicia Vescio, Maria Paola Landini, Ivano Dal Conte, Alberto Matteelli, Antonio Cristaudo, Marina Gaino, Marco Cusini, Anna Maria Barbui, Antonella Mencacci, Rosella De Nittis, Valeria Ghisetti, Elena Stroppiana, Anna Carannante
INTRODUCTION: Neisseria gonorrhoeae (NG) antimicrobial susceptibility trends to azithromycin, cefixime and ceftriaxone were analyzed, from 2009 to 2016, to monitor changing antimicrobial susceptibility concomitant with the change in prescribing practice in 2012 from cefixime, or ceftriaxone, to ceftriaxone plus azithromycin. Patient characteristics predictive to be infected by antibiotic resistant N. gonorrhoeae were estimated. Finally, the protocol for the treatment of gonorrhoea, in comparison with the international guidelines, was also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29240744/an-osteoarthritis-model-of-care-should-be-a-national-priority-for-new-zealand
#10
Jennifer Baldwin, Andrew Briggs, Warwick Bagg, Peter Larmer
Osteoarthritis is highly prevalent, disabling and costly to the person and the community. The burden of this chronic condition is predicted to increase dramatically over the coming decades. Healthcare spending on osteoarthritis is unsustainable and action is needed to improve care delivery. At present, there is an over-emphasis on surgical and pharmacological interventions, despite evidence supporting conservative treatments such as exercise, weight loss and education. While clinical guidelines provide recommendations regarding best practice (ie, what to do), they fail to address how to operationalise these recommendations into clinical practice...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240586/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#11
Feras M Ghazawi, Ramin Zargham, Mirko S Gilardino, Denis Sasseville, Fatemeh Jafarian
GENERAL PURPOSE: To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that manifest when the cicatrix fails to properly heal...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240555/daily-sugar-sweetened-beverage-consumption-by-disability-status-among-adults-in-23-states-and-the-district-of-columbia
#12
Sunkyung Kim, Sohyun Park, Dianna D Carroll, Catherine A Okoro
INTRODUCTION: Information on dietary intake, including sugar-sweetened beverages (SSBs), for adults with disabilities is limited. Such information can inform interventions to prevent chronic disease and promote health among adults with disabilities. The objective of this study was to describe the associations between SSB consumption and disability among adults. METHODS: We examined data on adults aged 18 years or older in 23 states and the District of Columbia who participated in the 2013 Behavioral Risk Factor Surveillance System (n = 150,760)...
December 14, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29240536/dementia-awareness-campaign-in-the-latino-community-a-novel-community-engagement-pilot-training-program-with-promotoras
#13
Nusha Askari, Ann Choryan Bilbrey, Iliana Garcia Ruiz, Marika Blair Humber, Dolores Gallagher-Thompson
OBJECTIVES: To create a curriculum about Alzheimer's disease and dementia, and to train Promotoras affiliated with a local community education and health advocacy organization, in order to raise awareness and knowledge of what dementia is, and how it can be recognized, in persons of Hispanic/Latino descent. METHODS: Community based participatory research (CPBR) model was used to create materials, implement training, and engage/empower Promotoras to educate the local community...
November 21, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29240364/wife-caregiver-experiences-in-the-patient-with-prostate-cancer-at-home
#14
Mary Elizabeth O'Brien, Nancy M Steele
This study explored the caregiving experiences of wives of patients with prostate cancer. Twenty wives revealed those older, educated, or married longer were less burdened by caregiving, but needed more information. Findings contribute new dimensions in caregiving for patients with prostate cancer and their wives.
January 2017: Urologic Nursing
https://www.readbyqxmd.com/read/29240330/regulating-black-box-medicine
#15
W Nicholson Price
Data drive modern medicine. And our tools to analyze those data are growing ever more powerful. As health data are collected in greater and greater amounts, sophisticated algorithms based on those data can drive medical innovation, improve the process of care, and increase efficiency. Those algorithms, however, vary widely in quality. Some are accurate and powerful, while others may be riddled with errors or based on faulty science. When an opaque algorithm recommends an insulin dose to a diabetic patient, how do we know that dose is correct? Patients, providers, and insurers face substantial difficulties in identifying high-quality algorithms; they lack both expertise and proprietary information...
2017: Michigan Law Review
https://www.readbyqxmd.com/read/29239997/predisposing-risk-factors-and-stress-fractures-in-division-i-cross-country-runners
#16
Kaci L Giffin, Kathy B Knight, Martha A Bass, Melinda W Valliant
The purpose of this study was to explore factors associated with increased stress fractures in collegiate cross country runners. Participants in this study were 42 male and female cross country runners at a Division I university. Each athlete completed a questionnaire regarding smoking status, vitamin/mineral intake, previous stress fracture history, birth control usage, menstrual status, and demographic information. Nutritional assessment via a 3-day food record and measurements of whole body, lumbar spine, and hip bone mineral densities (BMD) were also conducted on each athlete...
November 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239903/proposed-performance-based-metrics-for-the-future-funding-of-graduate-medical-education-starting-the-conversation
#17
Kelly J Caverzagie, Susan W Lane, Niraj Sharma, John Donnelly, Jeffrey R Jaeger, Heather Laird-Fick, John P Moriarty, Darilyn V Moyer, Sara L Wallach, Richard M Wardrop, Alwin F Steinmann
Graduate medical education (GME) in the United States is financed by contributions from both federal and state entities that total over $15 billion annually. Within institutions, these funds are distributed with limited transparency to achieve ill-defined outcomes. To address this, the Institute of Medicine convened a committee on the governance and financing of GME to recommend finance reform that would promote a physician training system that meets society's current and future needs. The resulting report provided several recommendations regarding the oversight and mechanisms of GME funding, including implementation of performance-based GME payments, but did not provide specific details about the content and development of metrics for these payments...
December 12, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29239774/the-clinical-use-of-mechanical-insufflation-exsufflation-in-children-with-neuromuscular-disorders-in-europe
#18
REVIEW
Brit Hov, Tiina Andersen, Vegard Hovland, Michel Toussaint
Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Ten centers from seven countries gave information on MI-E settings for 240 children aged 4 months to 17...
November 3, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29239735/burns-centre-and-fire-services-what-information-can-be-exchanged-to-manage-the-burn-patient
#19
O Pujji, B Nizar, J Bechar, D North, S Jeffery
AIM: To describe the experience of using a "Burns Extrication Form" at a regional Burns Centre. Communication between the fire services and burns team previously has been regarded as poor. Significant information is collected by the fire services at the scene and this can aid the management of the patient. METHODS: The Burns Extrication Form was devised to provide a clear framework of communication between the two services. Information regarding time frames, exposure to heat & smoke, fire loading (potential severity of a fire in a given space by measuring amount of combustible material in confined space), building construction, chemicals involved is passed to the medical team through this form through a National Health Service mailbox...
November 24, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29239728/wound-healing-of-cutaneous-substance-losses-based-on-infectious-inflammatory-and-traumatic-skin-disorders-the-experience-of-a-center
#20
K Khoshim, B Hersant, C Hotz, M SidAhmed-Mezi, J P Meningaud
INTRODUCTION: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon...
November 24, 2017: Annales de Chirurgie Plastique et Esthétique
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