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https://www.readbyqxmd.com/read/29908304/pathway-based-predictive-approaches-for-non-animal-assessment-of-acute-inhalation-toxicity
#1
REVIEW
Amy J Clippinger, David Allen, Holger Behrsing, Kelly A BéruBé, Michael B Bolger, Warren Casey, Michael DeLorme, Marianna Gaça, Sean C Gehen, Kyle Glover, Patrick Hayden, Paul Hinderliter, Jon A Hotchkiss, Anita Iskandar, Brian Keyser, Karsta Luettich, Lan Ma-Hock, Anna G Maione, Patrudu Makena, Jodie Melbourne, Lawrence Milchak, Sheung P Ng, Alicia Paini, Kathryn Page, Grace Patlewicz, Pilar Prieto, Hans Raabe, Emily N Reinke, Clive Roper, Jane Rose, Monita Sharma, Wayne Spoo, Peter S Thorne, Daniel M Wilson, Annie M Jarabek
New approaches are needed to assess the effects of inhaled substances on human health. These approaches will be based on mechanisms of toxicity, an understanding of dosimetry, and the use of in silico modeling and in vitro test methods. In order to accelerate wider implementation of such approaches, development of adverse outcome pathways (AOPs) can help identify and address gaps in our understanding of relevant parameters for model input and mechanisms, and optimize non-animal approaches that can be used to investigate key events of toxicity...
June 13, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29908287/characterization-of-nanomedicines-surface-coverage-using-molecular-probes-and-capillary-electrophoresis
#2
J-B Coty, F Varenne, A Benmalek, O Garsaa, I Le Potier, M Taverna, C Smadja, C Vauthier
A faithful characterization of nanomedicine (NM) is needed for a better understanding of their in vivo outcomes. Size and surface charge are studied with well-established methods. However, other relevant parameters for the understanding of NM behavior in vivo remain largely inaccessible. For instance, the reactive surface of nanomedicines, which are often grafted with macromolecules to decrease their recognition by the immune system, is excluded from a systematic characterization. Yet, it is known that a subtle modification of NM's surface characteristics (grafting density, molecular architecture and conformation of macromolecules) is at the root of major changes in the presence of biological components...
June 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908128/swedish-adaptation-of-the-general-medical-council-s-multisource-feedback-questionnaires-a-qualitative-study
#3
Jan-Eric Olsson, Solvig Ekblad, Bo Christer Bertilson, Eva Toth-Pal
Objectives: to explore potential users' opinions of a translated and culturally adapted Swedish version of the General Medical Council's MultiSource Feedback Questionnaires. Methods: In this qualitative study, we used content analysis on semi-structured interviews from 44 resident doctors, 29 medical colleagues and 28 patients to analyse their opinions of the Swedish adapted version, created through translation and expert review. Transcribed interview data concerning the informants' general thoughts about the tool were coded manually by three independent coders into categories, compiled as themes, and exemplified by citations...
June 15, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29908040/dual-energy-ct-for-noninvasive-staging-of-liver-fibrosis-accuracy-of-iodine-density-measurements-from-contrast-enhanced-data
#4
Keitaro Sofue, Masakatsu Tsurusaki, Achille Mileto, Tomoko Hyodo, Kosuke Sasaki, Tatsuya Nishii, Takaaki Chikugo, Norihisa Yada, Masatoshi Kudo, Kazuro Sugimura, Takamichi Murakami
AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy CT data can noninvasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (noncontrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29908026/growth-patterns-of-palestinian-children-from-birth-to-24-months
#5
Ali Albelbeisi, Zalilah Mohd Shariff, Chan Yoke Mun, Hejar Abdul-Rahman, Yehia Abed
Background: Growth faltering in early life can adversely affect health in later childhood and adulthood. Growth monitoring of children can provide evidence to help formulate effective strategies to address growth problems but such information on Palestinian children is lacking. Objectives: This study aimed to determine the growth patterns of children under 2 years in Gaza, Palestine. Methods: This retrospective cohort study was conducted in 2014 in 10 randomly selected primary health care clinics in 5 governorates of Gaza...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29908019/health-needs-and-priorities-of-syrian-refugees-in-camps-and-urban-settings-in-jordan-perspectives-of-refugees-and-health-care-providers
#6
Tala Al-Rousan, Zaker Schwabkey, Lara Jirmanus, Brett D Nelson
Background: The United Nations has declared the Syrian refugee crisis to be the biggest humanitarian emergency of our era. Neighbouring countries, such as Jordan, strain to meet the health needs of Syrian refugees in addition to their own citizens given limited resources. Objectives: This study aimed to determine the perspectives of Syrian refugees in Jordan, Jordanian health care providers and other stakeholders in addressing the public health issues of the refugee crisis...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29907560/validation-of-a-natural-language-processing-algorithm-for-detecting-infectious-disease-symptoms-in-primary-care-electronic-medical-records-in-singapore
#7
Antony Hardjojo, Arunan Gunachandran, Long Pang, Mohammed Ridzwan Bin Abdullah, Win Wah, Joash Wen Chen Chong, Ee Hui Goh, Sok Huang Teo, Gilbert Lim, Mong Li Lee, Wynne Hsu, Vernon Lee, Mark I-Cheng Chen, Franco Wong, Jonathan Siung King Phang
BACKGROUND: Free-text clinical records provide a source of information that complements traditional disease surveillance. To electronically harness these records, they need to be transformed into codified fields by natural language processing algorithms. OBJECTIVE: The aim of this study was to develop, train, and validate Clinical History Extractor for Syndromic Surveillance (CHESS), an natural language processing algorithm to extract clinical information from free-text primary care records...
June 11, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29907554/a-surveillance-infrastructure-for-malaria-analytics-provisioning-data-access-and-preservation-of-interoperability
#8
Mohammad Sadnan Al Manir, Jon Haël Brenas, Christopher Jo Baker, Arash Shaban-Nejad
BACKGROUND: According to the World Health Organization, malaria surveillance is weakest in countries and regions with the highest malaria burden. A core obstacle is that the data required to perform malaria surveillance are fragmented in multiple data silos distributed across geographic regions. Furthermore, consistent integrated malaria data sources are few, and a low degree of interoperability exists between them. As a result, it is difficult to identify disease trends and to plan for effective interventions...
June 15, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29907317/the-role-of-pharmacists-in-general-practice-a-realist-review
#9
REVIEW
Claire Anderson, Kevin Zhan, Matthew Boyd, Claire Mann
BACKGROUND: The review was carried out to inform the evaluation of the clinical pharmacists in general practice pilot scheme, a world leading initiative to improve health care delivery in England. Around 500 pharmacists are already working in general practice as part of the pilot, launched in July 2015. OBJECTIVES: The review attempts to explain the how pharmacists working in general practice is being implemented in the UK and beyond, what works well, what does not work so well and everything in-between...
June 12, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29907250/evaluating-risk-factors-for-differences-in-fibroid-size-and-number-using-a-large-electronic-health-record-population
#10
Michael J Bray, Eric S Torstenson, Sarah H Jones, Todd L Edwards, Digna R Velez Edwards
OBJECTIVE: To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS: This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and clinical information from patient electronic health records (EHRs) from the Vanderbilt University Medical Center. We performed multivariate regression analyses on the following outcomes: volume of largest fibroid, largest dimension of all fibroids, and number of fibroids (single vs multiple)...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907244/e-health-for-active-ageing-a-systematic-review
#11
REVIEW
Timothy David Robbins, Sarah N Lim Choi Keung, Theodoros N Arvanitis
Enabling successful active ageing is an international priority to meet the challenges of increasing life expectancy. Digital strategies, such as telemedicine and e-health, offer the potential to deliver active ageing in a cost-effective manner at scale. This article aims to establish the extent to which the research literature considers e-health-based and telemedicine-based active ageing interventions. A systematic review was conducted according to PRISMA standards. Independently, two authors searched the Cochrane, EMBASE & CINAHL databases, with subsequent independent extraction and semi-quantitative analysis...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907158/addressing-overuse-of-health-services-in-health-systems-a-critical-interpretive-synthesis
#12
REVIEW
Moriah E Ellen, Michael G Wilson, Marcela Vélez, Ruth Shach, John N Lavis, Jeremy M Grimshaw, Kaelan A Moat
BACKGROUND: Health systems are increasingly focusing on the issue of 'overuse' of health services and how to address it. We developed a framework focused on (1) the rationale and context for health systems prioritising addressing overuse, (2) elements of a comprehensive process and approach to reduce overuse and (3) implementation considerations for addressing overuse. METHODS: We conducted a critical interpretive synthesis informed by a stakeholder-engagement process...
June 15, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29907117/increasing-evidence-of-low-lymphatic-filariasis-prevalence-in-high-risk-loa-loa-areas-in-central-and-west-africa-a-literature-review
#13
REVIEW
Louise A Kelly-Hope, Janet Hemingway, Mark J Taylor, David H Molyneux
In West and Central Africa, there is a need to establish the prevalence of Wuchereria bancrofti in areas that are co-endemic for Loa loa, in order to implement the appropriate strategies to scale-up interventions for the elimination of lymphatic filariasis (LF). Due to the risk of severe adverse events (SAEs) to ivermectin in individuals with high L. loa microfilaraemia, the current strategy recommended by the World Health Organization (WHO) is twice yearly mass drug administration (MDA) with albendazole, supplemented by vector control targeting the Anopheles vectors...
June 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29907115/determinants-of-human-papillomavirus-vaccine-attitudes-an-interview-of-wisconsin-parents
#14
Kathrine L Barnes, Jeffrey J VanWormer, Shannon Stokley, Elizabeth R Vickers, Huong Q McLean, Edward A Belongia, Casper G Bendixsen
BACKGROUND: Parental attitudes play a key role in their decisions to vaccinate adolescents against the human papillomavirus (HPV). Little is known, however, about the formative experiences that shape parents' attitudes about the HPV vaccine. METHODS: We conducted semi-structured interviews with 25 parents of 11-17 year old adolescents in Wisconsin who changed their HPV vaccine attitudes (per prior surveys) over one year. A modified grounded theory approach was then used to generate primary themes of attitudinal determinants...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29907099/loss-of-job-related-right-to-healthcare-associated-with-employment-turnover-challenges-for-the-mexican-health-system
#15
Germán Guerra, Emilio Gutiérrez-Calderón, Nelly Salgado de Snyder, Víctor Hugo Borja-Aburto, Adolfo Martínez-Valle, Miguel Ángel González-Block
BACKGROUND: The Mexican health system segments access and right to healthcare according to worker position in the labour market. In this contribution we analyse how access and continuity of healthcare gets interrupted by employment turnover in the labour market, including its formal and informal sectors, as experienced by affiliates to the Mexican Institute of Social Security (IMSS) at national level, and of workers with type 2 diabetes (T2DM) in Mexico City. METHODS: Using data from the National Employment and Occupation Survey, 2014, and from IMSS electronic medical records for workers in Mexico City, we estimated annual employment turnover rates to measure the loss of healthcare access due to labour market dynamics...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29907091/end-stage-renal-disease-treated-in-provence-alpes-c%C3%A3-te-d-azur-12-years-follow-up-and-forecast-to-the-year-2030
#16
Anne-Claire Durand, Elisabeth Jouve, Jean-Christophe Delarozière, Mohamed Boucekine, Ghizlane Izaaryene, Adeline Crémades, Franck Mazoué, Bénédicte Devictor, Asmatullah Kakar, Roland Sambuc, Philippe Brunet, Stéphanie Gentile
BACKGROUND: This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d'Azur region (PACA) between 2004 and 2015, and forecasts up to 2030. METHODS: A longitudinal study was conducted on all ESRD patients treated in PACA and recorded in the French Renal Epidemiology and Information Network (REIN) during this period. Time trends and forecasts to 2030 were analyzed using Poisson regression models...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29906893/statistical-mechanics-of-high-density-bond-percolation
#17
P N Timonin
High-density (HD) percolation describes the percolation of specific κ-clusters, which are the compact sets of sites each connected to κ nearest filled sites at least. It takes place in the classical patterns of independently distributed sites or bonds in which the ordinary percolation transition also exists. Hence, the study of series of κ-type HD percolations amounts to the description of classical clusters' structure for which κ-clusters constitute κ-cores nested one into another. Such data are needed for description of a number of physical, biological, and information properties of complex systems on random lattices, graphs, and networks...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906741/group-medical-consultations-gmcs-and-tablet-based-online-support-group-sessions-in-the-follow-up-of-breast-cancer-a-multicenter-randomized-controlled-trial
#18
Annemiek Visser, Judith B Prins, Lisette Jansen, Sandra A Radema, Margrethe S Schlooz, Thijs van Dalen, Hanneke W M van Laarhoven
OBJECTIVE: Group medical consultations (GMCs) provide individual medical visits in the presence of ≤7 peer-patients. In the follow-up of breast cancer, we evaluated the efficacy of a new type of blended care My-GMC, a GMC combined with a tablet-based online app, consisting of three online support group sessions (SGS) and additional information. METHODS: This randomized controlled trial compared the effect of My-GMC (n = 59) with one individual medical visit (n = 50) (care as usual)...
June 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29906632/youtube-for-millennial-nursing-students-using-internet-technology-to-support-student-engagement-with-bioscience
#19
Amy Nb Johnston, Matthew J Barton, Grant A Williams-Pritchard, Michael Todorovic
Undergraduate nursing programs typically include students with limited 'on-campus' time who need learning resources that are flexible, technologically appropriate, remotely-accessible (mobile smart devices), and above all, engaging. This has presented academics with challenges surrounding institutional security firewalls, password-access requirements, intellectual property/ownership and staff/student privacy. To overcome these challenges a collection of evidence-based YouTube videos, posted on the Biological Sciences YouTube Channel, supported by the Biosciences in Nurse Education, and underpinned by Benner's pedagogical framework, were developed with the intention of moving students from novice to competent clinical bioscience users...
June 9, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29906623/gene-expression-analysis-of-isolated-salmonid-galt-leucocytes-in-response-to-pamps-and-recombinant-cytokines
#20
A Attaya, T Wang, J Zou, T Herath, A Adams, C J Secombes, S Yoon
Increased knowledge of the immune response of the intestine, a physiologically critical organ involved in absorption, secretion and homeostasis in a non-sterile environment, is needed to better understand the mechanisms involved in the induction of long-lasting immunity and, subsequently, the development of efficacious gastrointestinal immunization approaches. To this end, analysis of isolated gut cells will give an insight into the cell types present and their immune capability. Hence, in this study we first optimised a method for salmonid gut leucocyte isolation and characterised the cells on the basis of their expression of a range of selected cell markers associated with T & B cells and dendritic cells...
June 12, 2018: Fish & Shellfish Immunology
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