Amanda Worker, Pierre Berthert, Andrew J Lawrence, Seyed Mostafa Kia, Celso Arango, Richard Dinga, Silvana Galderisi, Birte Glenthøj, René S Kahn, Anoushka Leslie, Robin M Murray, Carmine M Pariante, Christos Pantelis, Mark Weiser, Inge Winter-van Rossum, Philip McGuire, Paola Dazzan, Andre F Marquand
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals. Normative modelling has been used to quantify this heterogeneity in established psychotic disorders by identifying regions of the cortex which are thinner than expected based on a normative healthy population range...
December 2, 2023: Translational Psychiatry