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Hemodynamic monitoring response

Rebecca Re, Edoardo Martinenghi, Alberto Dalla Mora, Davide Contini, Antonio Pifferi, Alessandro Torricelli
We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders...
October 2016: Neurophotonics
Wangde Dai, Elissa Cheung, Rick J Alleman, Justin B Perry, Mitchell E Allen, David A Brown, Robert A Kloner
PURPOSE: Dysfunctional mitochondria are considered to be the major source of intracellular reactive oxygen species and play a central role in the pathophysiology of myocardial ischemia/reperfusion. This study sought to determine effects of mitochondria-targeted cytoprotective peptide SBT-20 on myocardial infarct size in two different models of ischemia/reperfusion. METHODS: For in vivo studies, anesthetized Sprague Dawley rats were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion...
October 17, 2016: Cardiovascular Drugs and Therapy
Jana Ambrozic, Gabrijela Brzan Simenc, Katja Prokselj, Natasa Tul, Marta Cvijic, Miha Lucovnik
OBJECTIVE: To evaluate lung and cardiac ultrasound for assessment of fluid tolerance and fluid responsiveness in severe preeclamptic patients before and after delivery. METHODS: Severe preeclampsia patients and healthy term controls were included in the study. Lung ultrasound Echo Comet Score (ECS) was obtained using the 28-rib interspaces technique. Echocardiographic E/e' ratio, measured by pulsed wave and tissue Doppler, respectively, was used as a marker of diastolic left ventricular function...
October 13, 2016: Ultrasound in Obstetrics & Gynecology
Sarah K B Bick, Bradley S Folley, Jutta S Mayer, Sohee Park, P David Charles, Corrie R Camalier, Srivatsan Pallavaram, Peter E Konrad, Joseph S Neimat
OBJECTIVES: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. MATERIALS AND METHODS: We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
Karen Beets, Michael W Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M Chuva de Sousa Lopes, Lieve Umans, An Zwijsen
BACKGROUND: Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output in endothelial cells is highly context- and dose-dependent. Phosphorylation of the BMP intracellular effectors, SMAD1/5/9, is routinely used to monitor BMP signalling activity. To better understand the in vivo context-dependency of BMP-SMAD signalling, we investigated differences in BMP-SMAD transcriptional activity in different vascular beds during mouse embryonic and postnatal stages...
October 10, 2016: BMC Developmental Biology
Siyu Chen, Qi Liu, Xiao Shu, Brian Soetikno, Shanbao Tong, Hao F Zhang
Visible-light optical coherence tomography (Vis-OCT) is an emerging technology that can image hemodynamic response in microvasculature. Vis-OCT can retrieve blood oxygen saturation (sO2) mapping using intrinsic optical absorption contrast while providing high-resolution anatomical vascular structures at the same time. To improve the accuracy of Vis-OCT oximetry on vessels embedded in highly scattering medium, i.e., brain cortex, we developed and formulated a novel dual-depth sampling and normalization strategy that allowed us to minimize the detrimental effect of ubiquitous tissue scattering...
September 1, 2016: Biomedical Optics Express
Richard F Neville, Samit K Gupta, David J Kuraguntla
OBJECTIVE: Prosthetic grafts used for lower extremity revascularization and dialysis access fail because of hyperplastic stenosis and thrombosis. Graft surveillance is advocated to monitor function; however, graft failure can occur between episodic examinations. An innovative sensor with wireless, microchip technology allows automated surveillance with assessment of graft function using a "cloud"-based algorithm. We performed proof-of-concept experiments with in vitro and in vivo models to assess the feasibility such a real-time graft surveillance system...
September 29, 2016: Journal of Vascular Surgery
Richa Shukla, Jennifer Kramer, Yumei Cao, Jun Ying, Aylin Tansel, Annette Walder, Shailesh Advani, Hashem B El-Serag, Fasiha Kanwal
OBJECTIVES: Prior studies have demonstrated the efficacy of non-selective beta-blockers (NSBB) in preventing first variceal bleeding in patients with cirrhosis. However, little is known about the overall effectiveness of NSBB in routine clinical care. METHODS: We conducted a retrospective cohort study of cirrhotic patients without prior bleeding who initiated a NSBB (propranolol, nadolol) at any Veterans Administration facility between 2008 and 2013. The primary outcome was variceal bleeding within 12 months...
September 27, 2016: American Journal of Gastroenterology
Johanna Herajärvi, Tuomas Anttila, Henna Sarja, Caius Mustonen, Henri Haapanen, Tuomas Mäkelä, Fredrik Yannopoulos, Tuomo Starck, Mika Kallio, Hannu Tuominen, Ulla Puistola, Peeter Karihtala, Kai Kiviluoma, Vesa Anttila, Tatu Juvonen
BACKGROUND: Paraplegia is one of the most severe complications occurring after the repair of thoracic and thoracoabdominal aortic aneurysms. Remote ischemic preconditioning (RIPC) has been shown to mitigate neurologic damage, and this study assessed its efficacy in preventing spinal cord ischemia. METHODS: The study randomized 16 female pigs into an RIPC group (n = 8) and a control group (n = 8). The RIPC group underwent four cycles of 5-minute ischemia-reperfusion episodes by intermittent occlusion of the left iliac artery...
September 22, 2016: Annals of Thoracic Surgery
Jiahe Xie, Kai Cui, Huixin Hao, Yingxue Zhang, Hairuo Lin, Zhenhuan Chen, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze, Yulin Liao
BACKGROUND: Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well as insufficient autophagic flux. Acute or chronic hyperglycemia is a prognostic factor for patients with myocardial infarction. However, the effect of acute hyperglycemia on LV dysfunction of the hypertrophic heart and the mechanisms involved are still unclear. This study aimed to confirm our hypothesis that either acute or chronic hyperglycemia suppresses LV diastolic function and autophagic flux...
2016: Cardiovascular Diabetology
Takuya Otani, Tohru Futami, Atsushi Kita, Toshio Kitano, Takashi Saisu, Shinichi Satsuma, Yasuhiko Kawaguchi
BACKGROUND: Treatment for unstable slipped capital femoral epiphysis (SCFE) is challenging and controversial. For many years, the debate centered around closed treatments and especially the pros and cons of manual reduction and its concrete procedure. However, recent studies reported on open treatments such as open reduction through an anterior approach and modified Dunn procedure. Being in a period of such transition, we investigated the current status and future challenge of treatment for unstable SCFE...
September 6, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
M A Islam, M S Bari, M N Islam, M A Bari, S R Siddique, M Z Islam, M S Begum, S U Ahammed, M A Rahman
This cross-sectional analytical study was conducted in Cardiology & Medicine Department of Mymensingh Medical College Hospital. After fulfilling the exclusion & inclusion criteria, B-type natriuretic peptide concentrations were measured in a convenience sample of 100 predominantly male (94%) dyspnic patients who got admitted in Cardiology & Medicine Department of Mymensingh Medical College & Hospital from November 2013 to October 2014. The diagnosis of Congestive Heart Failure (CHF) was based on generally accepted Framingham criteria with corroborative information including hospital course (response to diuretics, vasodilators, inotropes or hemodynamic monitoring) and results of further cardiac testing, including echocardiography...
July 2016: Mymensingh Medical Journal: MMJ
Sascha Ketelhut, Florian Milatz, Walter Heise, Reinhard G Ketelhut
BACKGROUND: Regular physical activity is known to reduce arterial pressure (BP). In a previous investigation, we could prove that even a single bout of moderate-intensity continuous exercise (MICE) causes a prolonged reduction in BP. Whether high-intensity interval training (HIIT) has a favourable influence on BP, and therefore may be followed subjects and methods by a prolonged BP reduction, should be examined on the basis of blood pressure response after exercise and during a subsequent stress test...
September 2016: VASA. Zeitschrift Für Gefässkrankheiten
Mercedes Fernández Gacio, Ana Maria Agrelo Lousame, Susana Pereira, Clara Castro, Juliana Santos
BACKGROUND: Several locoregional techniques have been described for the management of acute and chronic pain after breast surgery. The optimal technique should be easy to perform, reproducible, with little discomfort to the patient, little complications, allowing good control of acute pain and a decreased incidence of chronic pain, namely intercostobrachial neuralgia for being the most frequent entity. OBJECTIVES: The aim of this study was to evaluate the paravertebral block with preoperative single needle prick for major breast surgery and assess initially the control of postoperative nausea and vomiting (PONV) and acute pain in the first 24h and secondly the incidence of neuropathic pain in the intercostobrachial nerve region six months after surgery...
September 2016: Brazilian Journal of Anesthesiology
Atila Kara, Sakir Akin, Can Ince
PURPOSE OF REVIEW: Critical illness includes a wide range of conditions from sepsis to high-risk surgery. All these diseases are characterized by reduced tissue oxygenation. Macrohemodynamic parameters may be corrected by fluids and/or vasoactive compounds; however, the microcirculation and its tissues may be damaged and remain hypoperfused. An evaluation of microcirculation may enable more physiologically based approaches for understanding the pathogenesis, diagnosis, and treatment of critically ill patients...
October 2016: Current Opinion in Critical Care
Taeyoon Son, Benquan Wang, Damber Thapa, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
Blood flow changes are highly related to neural activities in the retina. It has been reported that neural activity increases when flickering light stimulation of the retina is used. It is known that blood flow changes with flickering light stimulation can be altered in patients with vascular disease and that measurement of flicker-induced vasodilatation is an easily applied tool for monitoring functional microvascular alterations. However, details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood due to the limitation of existing techniques...
August 1, 2016: Biomedical Optics Express
Qian Li, Lin Li, Tianhao Yu, Qingliang Zhao, Chuanqing Zhou, Xinyu Chai
A vascular tree extraction algorithm is proposed to automatically extract independent and complete vascular trees from both background and other crossed vascular trees for photoacoustic microscopy (PAM) imaging. Extracted parameters include vascular tree centerline, diameters, boundaries and three-dimensional (3-D) direction along the tree. Based on the concept of blood vessel tracking, the proposed algorithm extracts complete vascular trees by utilizing a ray casting framework to realize functions which includes vessel direction estimation, vessel branching detection and vessel crossover point detection...
August 22, 2016: Journal of Biophotonics
Anthony S McLean
Echocardiography is pivotal in the diagnosis and management of the shocked patient. Important characteristics in the setting of shock are that it is non-invasive and can be rapidly applied.In the acute situation a basic study often yields immediate results allowing for the initiation of therapy, while a follow-up advanced study brings the advantage of further refining the diagnosis and providing an in-depth hemodynamic assessment. Competency in basic critical care echocardiography is now regarded as a mandatory part of critical care training with clear guidelines available...
2016: Critical Care: the Official Journal of the Critical Care Forum
Abdul Qadir Javaid, Hazar Ashouri, Alexis Dorier, Mozziyar Etemadi, J Alex Heller, Shuvo Roy, Omer T Inan
GOAL: Our objective is to provide a framework for extracting signals of interest from the wearable seismocardiogram (SCG) measured during walking at normal (subject's preferred pace) and moderately-fast (1.34 - 1.45 m/s) speeds. METHODS: We demonstrate, using empirical mode decomposition (EMD) and feature tracking algorithms, that the pre-ejection period (PEP) can be accurately estimated from a wearable patch that simultaneously measures electrocardiogram (ECG) and sternal acceleration signals...
August 16, 2016: IEEE Transactions on Bio-medical Engineering
Katsunori Oyama, Kaoru Sakatani
Simultaneous monitoring of brain activity with near-infrared spectroscopy and electroencephalography allows spatiotemporal reconstruction of the hemodynamic response regarding the concentration changes in oxyhemoglobin and deoxyhemoglobin that are associated with recorded brain activity such as cognitive functions. However, the accuracy of state estimation during mental arithmetic tasks is often different depending on the length of the segment for sampling of NIRS and EEG signals. This study compared the results of a self-organizing map and ANOVA, which were both used to assess the accuracy of state estimation...
2016: Advances in Experimental Medicine and Biology
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