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https://www.readbyqxmd.com/read/28930585/leishmaniasis-treatment-update-of-possibilities-for-drug-repurposing
#1
Valter Viana Andrade-Neto, Edezio Ferreira Cunha-Junior, Viviane Dos Santos Faioes, Thais Pereira Martins, Raphaela Lopes Silva, Leonor Laura Leon, Eduardo Caio Torres-Santos
The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania  parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28926515/is-the-age-at-menopause-a-cause-of-sexual-dysfunction-a-brazilian-population-based-study
#2
Caio Lett, Ana L R Valadares, Luiz F Baccaro, Adriana O Pedro, Jeffrey L Filho, Marcelo Lima, Lucia Costa-Paiva
OBJECTIVES: The aim of the study was to evaluate the association between age at menopause and sexual dysfunction and the components of sexual function in postmenopausal women. METHODS: In this cross-sectional population-based study, data of 540 women aged 45 to 60 years regarding the age they were when they achieved menopause and its association with sexual dysfunction (evaluated using the Short Personal Experiences Questionnaire) were obtained through interviews...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28920846/detection-of-the-incx3-plasmid-carrying-blakpc-3-in-a-serratia-marcescens-strain-isolated-from-a-kidney-liver-transplanted-patient
#3
Floriana Gona, Carla Caio, Gioacchino Iannolo, Francesco Monaco, Giuseppina Di Mento, Nicola Cuscino, Ignazio Fontana, Giovanna Panarello, Gaetano Maugeri, Maria Lina Mezzatesta, Stefania Stefani, Pier Giulio Conaldi
Dissemination of resistance to carbapenems among Enterobacteriaceae through plasmids is an increasingly important concern in health care worldwide. Here we report the first description of an IncX3 plasmid carrying the blaKPC-3 gene in a strain of Serratia marcescens isolated from a kidney-liver transplanted patient at the transplantation centre ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy). To localize the transposable element containing the resistance-associated gene Next-Generation Sequencing of the bacterial DNA was performed...
September 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28918654/stakeholders-perceptions-sought-to-inform-the-development-of-a-low-cost-mobile-robot-for-older-adults-a-qualitative-descriptive-study
#4
Justine S Sefcik, Michelle J Johnson, Mark Yim, Tessa Lau, Nicholas Vivio, Caio Mucchiani, Pamela Z Cacchione
Creative solutions are needed to support community-dwelling older adults residing in a variety of settings including their house, apartment, or Supportive Apartment Living (SAL) to promote independence and reduce the risk of nursing home replacement. The objective of this study was to gain an understanding of older adults' needs for physical, mental, and social activities to support the design and functionality of a low-cost mobile assistive robot. A qualitative descriptive study was designed which included three stakeholder focus groups (caregivers, clinicians, and older adults)...
September 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28916913/centromeric-enrichment-of-line-1-retrotransposons-and-its-significance-for-the-chromosome-evolution-of-phyllostomid-bats
#5
Cibele Gomes de Sotero-Caio, Diogo Cavalcanti Cabral-de-Mello, Merilane da Silva Calixto, Guilherme Targino Valente, Cesar Martins, Vilma Loreto, Maria José de Souza, Neide Santos
Despite their ubiquitous incidence, little is known about the chromosomal distribution of long interspersed elements (LINEs) in mammalian genomes. Phyllostomid bats, characterized by lineages with distinct trends of chromosomal evolution coupled with remarkable ecological and taxonomic diversity, represent good models to understand how these repetitive sequences contribute to the evolution of genome architecture and its link to lineage diversification. To test the hypothesis that LINE-1 sequences were important modifiers of bat genome architecture, we characterized the distribution of LINE-1-derived sequences on genomes of 13 phyllostomid species within a phylogenetic framework...
September 15, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28912660/effects-of-whole-body-vibration-on-the-neuromuscular-amplitude-of-vastus-lateralis-muscle
#6
Daniel T Borges, Liane B Macedo, Caio A A Lins, Catarina O Sousa, Jamilson S Brasileiro
The aim of this study was to investigate the effects of whole-body vibration (WBV) on vastus lateralis (VL) surface electromyographic (sEMG) amplitude during an isometric semi-squat exercise, using two different frequencies, and to verify the influence of additional filters on the analyzed sEMG signal's characteristics. Forty physically active women were randomly divided into two groups with 20 members each: one group performed an isometric semi-squat exercise at 30 Hz - while the other group performed the same exercise protocol at 50 Hz...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28902334/multicenter-randomized-clinical-trial-to-assess-the-effectiveness-of-intravitreal-injections-of-bevacizumab-triamcinolone-or-their-combination-in-the-treatment-of-diabetic-macular-edema
#7
Hermelino O Neto, Caio V Regatieri, Mário J Nobrega, Cristina Muccioli, Antonio M Casella, Rafael E Andrade, Mauricio Maia, Vinicius Kniggendorf, Magno Ferreira, André C Branco, Rubens Belfort
BACKGROUND AND OBJECTIVE: To evaluate the efficacy of combined bevacizumab-triamcinolone intravitreal injection in the treatment of diabetic macular edema (DME) compared to monotherapy. PATIENTS AND METHODS: At eight clinical sites, 111 patients with DME were randomly assigned to receive an intravitreal injection of bevacizumab (Avastin; Genentech, South San Francisco, CA), triamcinolone (Ophthalmos Pharmaceutical Industry, São Paulo-SP, Brazil), or their combination...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28890724/vacuolar-sequestration-of-paraquat-is-involved-in-the-resistance-mechanism-in-lolium-perenne-l-spp-multiflorum
#8
Caio A C G Brunharo, Bradley D Hanson
Lolium perenne L. spp. multiflorum (Lam.) Husnot (LOLMU) is a winter annual weed, common to row crops, orchards and roadsides. Glyphosate-resistant populations of LOLMU are widespread in California. In many situations, growers have switched to paraquat or other postemergence herbicides to manage glyphosate-resistant LOLMU populations. Recently, poor control of LOLMU with paraquat was reported in a prune orchard in California where paraquat has been used several times. We hypothesize that the low efficacy observed is due to the selection of a paraquat-resistant biotype of LOLMU...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28889116/challenging-the-concept-of-adding-more-drugs-in-pulmonary-arterial-hypertension
#9
EDITORIAL
Caio J C Dos Santos Fernandes, Marc Humbert, Rogerio Souza
No abstract text is available yet for this article.
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28872396/whole-body-vibration-on-performance-of-quadriceps-after-acl-reconstruction-a-blinded-randomized-controlled-trial
#10
Karinna Sonálya Aires da Costa, Daniel Tezoni Borges, Liane de Brito Macedo, Caio Alano de Almeida Lins, Jamilson Simões Brasileiro
CONTEXT: Whole body vibration (WBV) has been widely used in clinical and sport practice. These devices produce constant vibrations originating symmetrical waves that move along the vertical axis. It is suggested that mechanical stimuli produced by high vibration can be an alternative to improve neuromuscular performance and balance in different populations. However, there is still a lack of consensus in the literature regarding neurophysiological responses in the skeletal muscle immediately after the use of WBV, specifically in individuals subjected to ACL reconstruction...
September 5, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28871187/prolonged-fasting-elicits-increased-hepatic-triglyceride-accumulation-in-rats-born-to-dexamethasone-treated-mothers
#11
Lucas Carminatti Pantaleão, Gilson Murata, Caio Jordão Teixeira, Tanyara Baliani Payolla, Junia Carolina Santos-Silva, Daniella Esteves Duque-Guimaraes, Frhancielly S Sodré, Camilo Lellis-Santos, Juliana Camargo Vieira, Dailson Nogueira de Souza, Patrícia Rodrigues Gomes, Sandra Campos Rodrigues, Gabriel Forato Anhe, Silvana Bordin
We investigated the effect of dexamethasone during the last week of pregnancy on glucose and lipid metabolism in male offspring. Twelve-week old offspring were evaluated after fasting for 12-hours (physiological) and 60-hours (prolonged). Physiological fasting resulted in glucose intolerance, decreased glucose clearance after pyruvate load and increased PEPCK expression in rats born to dexamethasone-treated mothers (DEX). Prolonged fasting resulted in increased glucose tolerance and increased glucose clearance after pyruvate load in DEX...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838768/brazilian-guidelines-for-the-diagnosis-and-treatment-of-postmenopausal-osteoporosis
#12
Sebastião Cézar Radominski, Wanderley Bernardo, Ana Patrícia de Paula, Ben-Hur Albergaria, Caio Moreira, Cesar Eduardo Fernandes, Charlles H M Castro, Cristiano Augusto de Freitas Zerbini, Diogo S Domiciano, Laura M C Mendonça, Luciano de Melo Pompei, Mailze Campos Bezerra, Marco Antônio R Loures, Maria Celeste Osório Wender, Marise Lazaretti-Castro, Rosa M R Pereira, Sergio Setsuo Maeda, Vera Lúcia Szejnfeld, Victoria Z C Borba
Osteoporosis is the leading cause of fractures in the population older than 50 years. This silent disease affects primarily postmenopausal women and the elderly, and the morbidity and mortality rates are high. The main goal of treating osteoporosis is the prevention of fractures. The identification of populations at risk through early diagnosis and treatment is essential. The last Brazilian guideline for the treatment of postmenopausal osteoporosis was elaborated in 2002. Since then, new strategies for diagnosis and risk stratification have been developed, and drugs with novel action mechanisms have been added to the therapeutic arsenal...
2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28837031/can-ovarian-double-stimulation-in-the-same-menstrual-cycle-improve-ivf-outcomes
#13
Maria Cecília de Almeida Cardoso, Alessandra Evangelista, Cássio Sartório, George Vaz, Caio Luis Vieira Werneck, Fernando Marques Guimarães, Paulo Gallo de Sá, Maria Cecília Erthal
OBJECTIVE: To evaluate the double-stimulation protocol efficacy over conventional ovarian stimulation in recovering a more adequate number of oocytes and increase the number of embryos to be transferred or to be genetically analyzed. METHODS: A retrospective and comparative study with 13 patients who underwent unsuccessful in vitro fertilization (IVF) cycles with a conventional antagonist ovarian stimulation protocol and repeat the attempt with a double stimulation protocol...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28835854/retinal-and-choroidal-angiogenesis-a-review-of-new-targets
#14
REVIEW
Thiago Cabral, Luiz Guilherme M Mello, Luiz H Lima, Júlia Polido, Caio V Regatieri, Rubens Belfort, Vinit B Mahajan
Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient vision. The intraocular use of anti-vascular endothelial growth factor therapeutics has improved management of the retinal and choroidal neovascularization but some patients do not respond, suggesting other vascular mediators may also contribute to ocular angiogenesis...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28835008/thiamethoxam-and-picoxystrobin-reduce-the-survival-and-overload-the-hepato-nephrocitic-system-of-the-africanized-honeybee
#15
Caio E C Domingues, Fábio Camargo Abdalla, Paulo José Balsamo, Beatriz V R Pereira, Moema de Alencar Hausen, Monica Jones Costa, Elaine C M Silva-Zacarin
Apis mellifera perform important pollination roles in agroecosystems. However, there is often intensive use of systemic pesticides in crops, which can be carried to the colony by forage bees through the collection of contaminated pollen and nectar. Inside the colony, pollen loads are stored by bees that add honey and several enzymes to this pollen. Nevertheless, intra-colonial chronic exposure could induce sublethal effects in young bees exposed to a wide range of pesticides present in these pollen loads. This study was aimed to both determine the survival rate and evaluate the sublethal effects on the hepato-nephrocitic system in response to continuous oral exposure to lower concentrations of neonicotinoid thiamethoxam (TXT) and picoxystrobin fungicide (PXT)...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28827632/local-and-systemic-immunomodulatory-mechanisms-triggered-by-human-papillomavirus-transformed-cells-a-potential-role-for-g-csf-and-neutrophils
#16
Karla Lucia Fernandez Alvarez, Mariana Beldi, Fabiane Sarmanho, Renata Ariza Marques Rossetti, Caio Raony Farina Silveira, Giana Rabello Mota, Maria Antonieta Andreoli, Eliana Dias de Carvalho Caruso, Marcia Ferreira Kamillos, Ana Marta Souza, Haydee Mastrocalla, Maria Alejandra Clavijo-Salomon, José Alexandre Marzagão Barbuto, Noely Paula Lorenzi, Adhemar Longatto-Filho, Edmund Baracat, Rossana Verónica Mendoza Lopez, Luisa Lina Villa, Maricy Tacla, Ana Paula Lepique
Cervical cancer is the last stage of a series of molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses and evasion mechanisms, which culminates with tolerance toward tumor antigens. Our objective was to understand local and systemic changes in the interactions between HPV associated cervical lesions and the immune system as lesions progress to cancer. Locally, we observed higher cervical leukocyte infiltrate, reflected by the increase in the frequency of T lymphocytes, neutrophils and M2 macrophages, in cancer patients...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819256/fbn30-in-wild%C3%A2-anopheles-gambiae-functions-as-a-pathogen-recognition-molecule-against-clinically-circulating-plasmodium-falciparum-in-malaria-endemic-areas-in-kenya
#17
Guodong Niu, Genwei Zhang, Caio Franca, Yingjun Cui, Stephen Munga, Yaw Afrane, Jun Li
Malaria is a worldwide health problem that affects two-thirds of the world population. Plasmodium invasion of anopheline mosquitoes is an obligatory step for malaria transmission. However, mosquito-malaria molecular interactions in nature are not clear. A genetic variation within mosquito fibrinogen related-protein 30 (FBN30) was previously identified to be associated with Plasmodium falciparum infection in natural Anopheles gambiae populations at malaria endemic areas in Kenya, and reducing FBN30 expression by RNAi makes mosquitoes more susceptible to P...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800970/guidelines-of-the-brazilian-society-of-rheumatology-for-the-diagnosis-and-treatment-of-osteoporosis-in-men
#18
REVIEW
Marco Antônio R Loures, Cristiano Augusto F Zerbini, Jaime S Danowski, Rosa Maria R Pereira, Caio Moreira, Ana Patrícia de Paula, Charlles Heldan M Castro, Vera Lúcia Szejnfeld, Laura Maria C Mendonça, Sebastião C Radominiski, Mailze C Bezerra, Ricardo Simões, Wanderley M Bernardo
Osteoporosis, a metabolic disease characterized by low bone mass, deterioration of the bone tissue microarchitecture and increased susceptibility to fractures, is commonly regarded as a women's health problem. This point of view is based on the fact that compared with men, women have lower bone mineral density and longer lifespans and lose bone mass faster, especially after menopause, due to a marked decrease in serum estrogen levels. However, in the last 20 years, osteoporosis in men has become recognized as a public health problem due to the occurrence of an increasingly higher number of fragility fractures...
2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28799955/a-serotonergic-deficit-in-the-dorsal-periaqueductal-gray-matter-may-underpin-enhanced-panic-like-behavior-in-diabetic-rats
#19
Eder Gambeta, Caio C Sestile, Manoela V Fogaça, Francisco S Guimarães, Elisabeth A Audi, Joice M da Cunha, Hélio Zangrossi, Paula Shimene de Melo Yamashita, Janaina M Zanoveli
It is known that diabetic (DBT) animals present dysregulation on the serotonergic system in several brain areas associated with anxiety-like responses. The aim of this study was to investigate the involvement of 5-HT1A receptors on dorsal periaqueductal gray (dPAG) in the behavioral response related to panic disorder in type-1 DBT animals. For this, the escape response by electric stimulation (ES) of dPAG in DBT and normoglycemic (NGL) animals was assessed. Both NGL and DBT animals were exposed to an open-field test (OFT) 28 days after DBT confirmation...
August 9, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28798803/preparation-of-a-nanoemulsion-with-carapa-guianensis-aublet-meliaceae-oil-by-a-low-energy-solvent-free-method-and-evaluation-of-its-preliminary-residual-larvicidal-activity
#20
Flávia L M Jesus, Fernanda B de Almeida, Jonatas L Duarte, Anna E M F M Oliveira, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Regina Gendzelevski Kelmann, José C T Carvalho, Ana C Lira-Guedes, Marcelino Guedes, Conxita Solans, Caio P Fernandes
Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpenoids)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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