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https://www.readbyqxmd.com/read/28217995/iron-catalyzed-synthesis-of-oxindoles-application-to-the-preparation-of-pyrroloindolines
#1
Valquírio G Correia, Juliana C Abreu, Caio A E Barata, Leandro H Andrade
A novel and highly efficient synthetic approach to pyrroloindolines has been developed. The process is based on tandem radical addition/cyclization with inexpensive iron catalyst. This method tolerates a wide range of N-methyl-N-arylacrylamides as well carbamoyl radicals, providing access to a variety of functionalized 3,3-disubstituted oxindoles, key intermediates for many bioactive pyrroloindolines such as (±)-esermethole, (±)-deoxyeseroline, and (±)-physovenol methyl ether.
February 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/28214607/real-time-liver-uptake-and-biodistribution-of-magnetic-nanoparticles-determined-by-ac-biosusceptometry
#2
Caio C Quini, André G Próspero, Marcos F F Calabresi, Gustavo M Moretto, Nicholas Zufelato, Sunil Krishnan, Diana R Pina, Ricardo B Oliveira, Oswaldo Baffa, Andris F Bakuzis, Jose R A Miranda
We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR)...
February 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28214208/reduced-immunohistochemical-expression-of-adhesion-molecules-in-vitiligo-skin-biopsies
#3
Adriane Reichert Faria, Juliana Elizabeth Jung, Caio César Silva de Castro, Lucia de Noronha
Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epidermis of vitiligo and non lesional vitiligo skin. Sixty-six specimens of lesional and non lesional skin from 33 volunteers with vitiligo were evaluated by immunohistochemistry using anti-beta-catenin, anti-E-cadherin, anti-laminin, anti-beta1 integrin, anti-collagen IV, anti-ICAM-1 and anti-VCAM-1 antibodies. Biopsies of vitiligo skin demonstrated a significant reduction in the expression of laminin and integrin...
December 30, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28213126/the-galactose-induced-decrease-in-phosphate-levels-leads-to-toxicity-in-yeast-models-of-galactosemia
#4
Caio M Machado, Evandro A De-Souza, Ana Luiza F V De-Queiroz, Felipe S A Pimentel, Guilherme F S Silva, Fabio M Gomes, Mónica Montero-Lomelí, Claudio A Masuda
Classic galactosemia is an inborn error of metabolism caused by deleterious mutations in the GALT gene. A number of evidences indicate that the galactose-1-phosphate accumulation observed in patient cells is a cause of toxicity in this disease. Nevertheless, the consequent molecular events caused by the galactose-1-phosphate accumulation remain elusive. Here we show that intracellular inorganic phosphate levels decreased when yeast models of classic galactosemia were exposed to galactose. The decrease in phosphate levels is probably due to the trapping of phosphate in the accumulated galactose-1-phosphate since the deletion of the galactokinase encoding gene GAL1 suppressed this phenotype...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212007/catalytic-enantioselective-transformations-involving-c-h-bond-cleavage-by-transition-metal-complexes
#5
Christopher G Newton, Shou-Guo Wang, Caio C Oliveira, Nicolai Cramer
The development of new methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C-H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation...
February 17, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28208234/the-influence-of-traumatic-occlusion-on-the-repair-process-for-teeth-following-subluxation
#6
Marina Fuzette Amaral, Caio Vinicius Lourenço Debortoli, Wilson Roberto Poi, Sônia Regina Panzarini, Daniela Atili Brandini
BACKGROUND/AIM: Traumatic occlusion can cause morphofunctional alterations that interfere in the homeostasis of the periodontium The aim of this study was to assess the influence of traumatic occlusion (TO) on the periodontal repair process for teeth following subluxation. MATERIALS AND METHODS: Ninety Wistar rats aged 12 weeks were divided into three groups: control (C), subluxation (S) and subluxation with traumatic occlusion (S+TO). Subluxation was created with an impact force of 900 cN applied by a tensiometer and TO was created with a direct composite resin filling...
February 16, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28192507/correction-socioeconomic-status-is-not-related-with-facial-fluctuating-asymmetry-evidence-from-latin-american-populations
#7
Mirsha Quinto-Sánchez, Celia Cintas, Caio Cesar Silva de Cerqueira, Virginia Ramallo, Victor Acuña-Alonzo, Kaustubh Adhikari, Lucía Castillo, Jorge Gomez-Valdés, Paola Everardo, Francisco De Avila, Tábita Hünemeier, Claudia Jaramillo, Williams Arias, Macarena Fuentes, Carla Gallo, Giovani Poletti, Lavinia Schuler-Faccini, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Javier Rosique, Andrés Ruiz-Linares, Rolando González-José
[This corrects the article DOI: 10.1371/journal.pone.0169287.].
2017: PloS One
https://www.readbyqxmd.com/read/28189084/synthesis-and-trypanocidal-activity-of-a-library-of-4-substituted-2-1h-pyrrolo-3-2-c-pyridin-2-yl-propan-2-ols
#8
Michael N Balfour, Caio H Franco, Carolina B Moraes, Lucio H Freitas-Junior, Hélio A Stefani
A library of 16 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols 17-32 has been synthesized for use in biological testing against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. The 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols 17-32 were subjected to biological testing to evaluate their efficacy against intracellular Trypanosoma cruzi (Y strain) amastigotes infecting U2OS human cells, with benznidazole as a reference compound. The assay was performed in duplicate (two independent experiments) and submitted to High Content Analysis (HCA) for determination of trypanocidal activity...
February 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28177560/effects-of-an-endodontic-auxiliary-chemical-substance-on-the-bond-strength-of-two-methacrylate-based-endodontic-sealers-to-dentin
#9
Roger Nicolini Fuzinatto, Ana Paula Farina, Matheus Albino Souza, Daniela Cristina Miyagaki, Caio Cézar Randi Ferraz, Doglas Cecchin
PURPOSE: To evaluate the influence of irrigation protocols and drying procedures on the bond strength of two methacrylate-based sealers to dentin and the associated failure pattern using scanning electron microscopy (SEM). MATERIALS AND METHODS: Fifty single-rooted human teeth were prepared with an irrigation protocol using either 5.25% sodium hypochlorite (NaOCl) or 2% chlorhexidine (CHX) and 17% EDTA (ethylenediaminetetraacetic acid) for smear layer removal. The following subgroups were also created based on drying of the root canal walls: paper points, the canals were blot dried with paper points with the last one appearing dry; or, ethanol, excess distilled water was removed with paper points followed by dehydration with 95% ethanol for 1 min and blotting with paper points...
February 8, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28174518/assessing-music-perception-in-young-children-evidence-for-and-psychometric-features-of-the-m-factor
#10
Caio G Barros, Walter Swardfager, Sylvain Moreno, Graziela Bortz, Beatriz Ilari, Andrea P Jackowski, George Ploubidis, Todd D Little, Alexandra Lamont, Hugo Cogo-Moreira
Given the relationship between language acquisition and music processing, musical perception (MP) skills have been proposed as a tool for early diagnosis of speech and language difficulties; therefore, a psychometric instrument is needed to assess music perception in children under 10 years of age, a crucial period in neurodevelopment. We created a set of 80 musical stimuli encompassing seven domains of music perception to inform perception of tonal, atonal, and modal stimuli, in a random sample of 1006 children, 6-13 years of age, equally distributed from first to fifth grades, from 14 schools (38% private schools) in So Paulo State...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28172722/p301-non-familial-small-bowel-carcinomas-in-crohn-s-disease-clinico-pathological-molecular-and-prognostic-features
#11
A Di Sabatino, A Vanoli, D Furlan, P Giuffrida, C Klersy, F Grillo, R Fiocca, C Mescoli, M Rugge, G Nesi, P Fociani, G Sampietro, S Ardizzone, O Luinetti, A Calabrò, F Tonelli, U Volta, D Santini, G Caio, L Elli, S Ferrero, G Latella, A Ciardi, G Solina, A Rizzo, C Ciacci, F P D'Armiento, M Salemme, V Villanacci, R Cannizzaro, V Canzonieri, L Reggiani Bonetti, L Biancone, G Monteleone, A Orlandi, G Santeusanio, M C Macciomei, R D'Incà, V Perfetti, G Sandri, M Silano, A M Florena, A G Giannone, C Papi, L Coppola, P Usai, A Maccioni, M Astegiano, P Migliora, R Manca, M Martino, D Trapani, R Cerutti, P Alberizzi, R Riboni, F Sessa, M Paulli, E Solcia, G R Corazza
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167564/multiclonal-expansion-of-klebsiella-pneumoniae-isolates-producing-ndm-1-in-rio-de-janeiro-brazil
#12
Caio Augusto Martins Aires, Polyana Silva Pereira, Carlos Felipe Machado de Araujo, Thiago Pavoni Gomes Chagas, Jane Cleide Oliveira, Sibelle Nogueira Buonora, Rodolpho Mattos Albano, Ana Paula D'Alincourt Carvalho-Assef, Marise Dutra Asensi
We characterized NDM-1-producing Klebsiella spp. isolates from Rio de Janeiro, Brazil. PCR was applied for resistance and virulence determinants. The genetic context of blaNDM was determined by S1 PFGE and hybridization. The genotyping were performed by PFGE and MLST. Most isolates carried multiple resistance genes and remained susceptible to amikacin, fosfomycin/trometamol, polymyxin B and tigecycline. The spread of NDM-1-producing K. pneumoniae was not associated with a clonal expansion and appears to be associated with Tn3000...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167349/proportional-thresholding-in-resting-state-fmri-functional-connectivity-networks-and-consequences-for-patient-control-connectome-studies-issues-and-recommendations
#13
Martijn van den Heuvel, Siemon de Lange, Andrew Zalesky, Caio Seguin, Thomas Yeo, Ruben Schmidt
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "thresholding" of the connectivity matrix, selecting the set of edges that together form the graph on which network organization is evaluated. To avoid systematic differences in absolute number of edges, studies have argued against the use of an "absolute threshold" in case-control studies and have proposed the use of "proportional thresholding" instead, in which a pre-defined number of strongest connections are selected as network edges, ensuring equal network density across datasets...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28159331/light-stick-a-problem-of-marine-pollution-in-brazil
#14
Caio Cesar-Ribeiro, Helena Costi Rosa, Daniele Oliveira Rocha, Camila Galli Baldini Dos Reis, Tabata Sarti Prado, Daniela Hernandes Coimbra Muniz, Raquel Carrasco, Flávia Milão Silva, José Eduardo Martinelli-Filho, Maria Fernanda Palanch-Hans
Light-sticks are used as bait in surface long-line fishing, to capture swordfish and other large pelagic predators. When discharged in the ocean, it may reach the beaches. The traditional Brazilian community of Costa dos Coqueiros, Bahia, use light-sticks as a medicine for rheumatism, vitiligo and mycoses. It may affect the marine life when its content leak in the open ocean. This work evaluated and identified the acute and chronic toxicity of the light-stick. A high acute toxicity was observed in the mobility/mortality of Artemia sp...
January 31, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28158585/evolution-and-diversity-of-transposable-elements-in-vertebrate-genomes
#15
Cibele G Sotero-Caio, Roy N Platt, Alexander Suh, David A Ray
No abstract text is available yet for this article.
February 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28158268/human-mobility-in-large-cities-as-a-proxy-for-crime
#16
Carlos Caminha, Vasco Furtado, Tarcisio H C Pequeno, Caio Ponte, Hygor P M Melo, Erneson A Oliveira, José S Andrade
We investigate at the subscale of the neighborhoods of a highly populated city the incidence of property crimes in terms of both the resident and the floating population. Our results show that a relevant allometric relation could only be observed between property crimes and floating population. More precisely, the evidence of a superlinear behavior indicates that a disproportional number of property crimes occurs in regions where an increased flow of people takes place in the city. For comparison, we also found that the number of crimes of peace disturbance only correlates well, and in a superlinear fashion too, with the resident population...
2017: PloS One
https://www.readbyqxmd.com/read/28152396/insulin-resistance-atherogenicity-and-iron-metabolism-in-multiple-sclerosis-with-and-without-depression-associations-with-inflammatory-and-oxidative-stress-biomarkers-and-uric-acid
#17
Sayonara Rangel Oliveira, Ana Paula Kallaur, Josiane Lopes, Andrea Name Colado Simão, Edna Maria Vissoci Reiche, Elaine Regina Delicato de Almeida, Helena Kaminami Morimoto, Wildea Lice de Carvalho Jennings de Pereira, Daniela Frizon Alfieri, Tamires Flauzino, Caio de Meleck Proença, Anna Maria Gomes, Damacio Ramón Kaimen-Maciel, Michael Maes
Depression is accompanied by metabolic disorders in iron metabolism, lipoproteins, and insulin resistance. We measured plasma levels of ferritin, iron, lipids, insulin, and glucose and computed the homeostasis model assessment (HOMA2IR) and atherogenic index of plasma (AIP) in MS patients with and without depression and healthy controls. Explanatory variables were serum uric acid, interleukin (IL)-6, lipid hydroperoxides (CL-LOOH), albumin, and C-reactive protein (CRP). Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), neurological disability using the Expanded Disability Status Scale (EDSS), and disease progression using ∆EDSS over five years earlier...
December 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28137400/effects-of-plantar-foot-sensitivity-manipulation-on-postural-control-of-young-adult-and-elderly
#18
Álvaro S Machado, Caio Borella Pereira da Silva, Emmanuel S da Rocha, Felipe P Carpes
INTRODUCTION: Subjects with sensorial losses present balance deficits. Although such condition is often observed among elderly, there is discussion concerning the dependence on sensorial information for body sway control in the elderly without sensorial losses. PURPOSE: We investigated the effects of foot sensitivity manipulation on postural control during upright standing in young adults and independent elderly (n=19/group). METHODS: Plantar sensitivity was evaluated by esthesiometry, and speed of center of pressure shift data during upright posture were evaluated for each foot using a baropodometer while the subjects were standing with eyes open or closed...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28117476/an-initial-experience-with-a-digital-drainage-system-during-the-postoperative-period-of-pediatric-thoracic-surgery
#19
Altair da Silva Costa, Thiago Bachichi, Caio Holanda, Luiz Augusto Lucas Martins De Rizzo
Objective: To report an initial experience with a digital drainage system during the postoperative period of pediatric thoracic surgery. Methods: This was a prospective observational study involving consecutive patients, ≤ 14 years of age, treated at a pediatric thoracic surgery outpatient clinic, for whom pulmonary resection (lobectomy or segmentectomy via muscle-sparing thoracotomy) was indicated. The parameters evaluated were air leak (as quantified with the digital system), biosafety, duration of drainage, length of hospital stay, and complications...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28094904/hormetic-effects-of-glyphosate-on-plants
#20
REVIEW
Ivana Pfs Brito, Leandro Tropaldi, Caio A Carbonari, Edivaldo D Velini
As all herbicides act on pathways or processes crucial to plants, in an inhibitory or stimulatory way, low rates of any herbicide might be used to modulate plant growth, development, or plant composition. Glyphosate is the most used pesticide in the world, and very low rates of this herbicide can stimulate plant growth, an effect called hormesis. Several studies have shown that glyphosate applications at low rates can increase plant growth, induce shikimic acid accumulation, increase photosynthesis and stomatal opening, increase seed production, and shorten the plant life cycle...
January 17, 2017: Pest Management Science
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