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https://www.readbyqxmd.com/read/28634640/the-microbiome-of-eucalyptus-roots-under-different-management-conditions-and-its-potential-for-biological-nitrogen-fixation
#1
Eduardo da Siva Fonseca, Raquel Silva Peixoto, Alexandre Soares Rosado, Fabiano de Carvalho Balieiro, James M Tiedje, Caio Tavora Coelho da Costa Rachid
Eucalyptus plantations offer a cost-effective and renewable source of raw material. There is substantial interest in improving forestry production, especially through sustainable strategies such as the use of plant growth-promoting bacteria. However, little is known about Eucalyptus microbiology. In this study, the endophytic bacterial community was assessed in Eucalyptus urograndis roots using culture-dependent and culture-independent techniques with plants grown under different conditions. Three phyla accounted for approximately 95% of the community, with Actinobacteria corresponding to approximately 59%...
June 21, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28632730/phase-2-study-of-combination-spi-1620-with-docetaxel-as-second-line-advanced-biliary-tract-cancer-treatment
#2
Richard Kim, E Gabriela Chiorean, Manik Amin, Caio Max S Rocha-Lima, Jitendra Gandhi, William P Harris, Tao Song, David Portnoy
BACKGROUND: This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS: Eligible patients received continuous cycles of combination therapy with SPI-1620 (11 μg m(-2)) and docetaxel (75 mg m(-2)) intravenously every 3 weeks until disease progression (PD) or intolerable toxicity...
June 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28603933/pretarsal-structures-in-leiodidae-and-agyrtidae-coleoptera-staphylinoidea
#3
Pedro Gnaspini, Caio Antunes-Carvalho, Richard A B Leschen
We analysed pretarsal characters of 87 species of Leiodidae (including 10 cholevines and representatives of all tribes and ca. 60% of the genera of non-cholevines), five species of Agyrtidae, and nine representatives of outgroup taxa (Hydraenidae, Staphylinidae, Hydrophilidae, and Histeridae) using scanning electron microscopy. We focused our observations on the architecture of the empodium (including the sclerites and associated setae), the shape and composition of the medial projection of the distal margin of the terminal tarsomere, and the armature of the claws, which were considered a promising source of information for delimiting supraspecific taxa in our previous study...
June 11, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28602744/prevalence-and-factors-associated-with-neck-pain-a-population-based-study
#4
Caio Vitor Dos Santos Genebra, Nicoly Machado Maciel, Thiago Paulo Frascareli Bento, Sandra Fiorelli Almeida Penteado Simeão, Alberto De Vitta
BACKGROUND: Neck pain is a musculoskeletal condition with high prevalence that may affect the physical, social, and psychological aspects of the individual, contributing to the increase in costs in society and business. OBJECTIVE: To determine the prevalence of neck pain and associated factors in a population-based sample of adults aged 20 and more. METHODS: Cross-sectional study based on a population survey. A total number of 600 individuals were interviewed in their homes, and the following data were collected: (1) participant characteristics (demographic, socioeconomic, and work-related aspects) using a pre-coded questionnaire; (2) physical activity level using the IPAQ; and (3) musculoskeletal symptoms using the Nordic questionnaire...
May 20, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28591336/prognostic-factors-affecting-outcomes-in-multivisceral-en-bloc-resection-for-colorectal-cancer
#5
Caio Sergio Rizkallah Nahas, Sergio Carlos Nahas, Ulysses Ribeiro-Junior, Leonardo Bustamante-Lopez, Carlos Frederico Sparapan Marques, Rodrigo Ambar Pinto, Antonio Rocco Imperiale, Guilherme Cutait Cotti, William Carlos Nahas, Daher Cezar Chade, Dariane Sampaio Piato, Fabio Busnardo, Ivan Cecconello
OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records...
May 2017: Clinics
https://www.readbyqxmd.com/read/28591287/large-colloid-drusen-analyzed-with-structural-en-face-optical-coherence-tomography
#6
Nathália Corbelli Roberti, João Rafael de Oliveira Dias, Eduardo Amorim Novais, Caio Saito Regatieri, Rubens Belfort
Drusen are extracellular deposits between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. Large colloid drusen (LCD) are located below the RPE and are characterized by multiple, large, dome-shaped RPE detachments, with marked attenuation of the ellipsoid zone overlaying the drusen. This report presents the structural en face optical coherence tomography (OCT) findings of LCD and relates them to findings from fluorescein and indocyanine green angiography...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28570126/second-and-third-metatarsophalangeal-plantar-plate-tears-diagnostic-performance-of-direct-and-indirect-mri-features-using-surgical-findings-as-the-reference-standard
#7
André Fukunishi Yamada, Michel D Crema, Caio Nery, Daniel Baumfeld, Tania Szejnfeld Mann, Abdalla Y Skaf, Artur da Rocha Correa Fernandes
OBJECTIVE: The objective of our study was to assess the diagnostic performance and associations of the direct and indirect MRI features of the metatarsophalangeal (MTP) joint that are thought to be related to tears of the plantar plate (PP) using surgical findings as the reference standard. MATERIALS AND METHODS: We retrospectively included 23 patients with symptomatic instability of lesser MTP joints who had undergone preoperative 1.5-T MRI and surgical assessment...
June 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28554847/panicolytic-like-action-of-bradykinin-in-the-dorsal-periaqueductal-gray-through-%C3%AE-opioid-and-b2-kinin-receptors
#8
Caio César Sestile, Jhonatan Christian Maraschin, Vanessa Scalco Gama, Hélio Zangrossi, Frederico Guilherme Graeff, Elisabeth Aparecida Audi
A wealth of evidence has shown that opioid and kinin systems may control proximal defense in the dorsal periaqueductal gray matter (dPAG), a critical panic-associated area. Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the μ-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior. A similar inhibitory effect has also been reported after local administration of bradykinin (BK), which is blocked by the non-selective opioid receptor antagonist naloxone...
May 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28545895/molluscicidal-potential-of-heterorhabditis-baujardi-rhabditida-heterorhabditidae-strain-lpp7-on-lymnaea-columella-gastropoda-pulmonata-an-alternative-for-biological-control-of-fasciolosis
#9
Victor Menezes Tunholi, P O Lorenzoni, Ygor Henrique da Silva, Vinícius Menezes Tunholi-Alves, Jankerle Neves Boeloni, Maria Aparecida da Silva, Caio Oliveira Monteiro, M C A Prata, J Pinheiro, Isabella Vilhena Freire Martins
This study elucidated for the first time, under laboratory conditions, the susceptibility of Lymnaea columella to infective juveniles of Heterorhabditis baujardi LPP7. Exposure to the nematodes induced an average mortality rate of 66.66% in the population of L. columella, with the highest values attained from the second week after exposure onward. In addition, all the reproductive parameters analyzed (total number of eggs, number of egg masses, number of eggs laid/snail, embryo hatching rate and content of galactogen stored in the albumen gland) changed as a result of the infection...
May 22, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28533429/fibrinogen-domain-of-frep1-is-a-broad-spectrum-malaria-transmission-blocking-vaccine-antigen
#10
Guodong Niu, Caio Franca, Genwei Zhang, Wanlapa Roobsoong, Wang Nguitragool, Xiaohong Wang, Jetsumon Prachumsri, Noah S Butler, Jun Li
FREP1 in mosquito midguts facilitates P. falciparum parasite transmission. Fibrinogen-like (FBG) domain of FREP1 is highly conserved (>90% identical) among Anopheles species from different continents, suggesting that anti-FBG antibodies may block malaria transmission to all anopheline mosquitoes. Using standard membrane-feeding assays, anti-FREP1 polyclonal antibodies significantly blocked transmission of P. berghei and P. vivax to An. gambiae and An. dirus respectively. Furthermore, in vivo studies of mice immunized with FBG achieved >75% blocking efficacy of P...
May 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28511054/synthesis-and-in-vitro-anticancer-activity-of-new-2-thioxo-oxazolidin-4-one-derivatives
#11
Júlia Furtado Campos, Michelly Cristiny Pereira, Wanessa Layssa Batista de Sena, Caio Gomes de Barros Martins, Jamerson Ferreira de Oliveira, Cezar Augusto da Cruz Amorim, Moacyr Jesus Barreto de Melo Rêgo, Marina Galdino da Rocha Pitta, Maria do Carmo Alves de Lima, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta
BACKGROUND: Oxazolidinones derivatives exhibit different biological properties, including anticancer activity. This work aimed to investigate the anticancer potential of five novel 2-Thioxo-oxazolidin-4-one derivatives. METHODS: Cytotoxicity assays were performed in human peripheral blood mononuclear cells (PBMCs) from healthy individuals and seven tumor cell lines. Apoptosis detection and cell cycle were evaluated by flow cytometry and the expression of genes involved in cell death processes by Real-Time PCR...
March 18, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28485107/low-doses-of-glyphosate-enhance-growth-co2-assimilation-stomatal-conductance-and-transpiration-in-sugarcane-and-eucalyptus
#12
Renan F Nascentes, Caio A Carbonari, Plinio S Simões, Marcela C Brunelli, Edivaldo D Velini, Stephen O Duke
INTRODUCTION: Sublethal doses of herbicides can enhance plant growth and stimulate other process, an effect known as hormesis. The magnitude of hormesis is dependent on the plant species, the herbicide and its dose, plant development stage, and environmental parameters. Glyphosate hormesis is well established, but relatively little is known of the mechanism of this phenomenon. The objective of this study was to determine if low doses of glyphosate that cause growth stimulation in sugarcane and eucalyptus concomitantly stimulate CO2 assimilation...
May 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28480172/high-sucrolytic-activity-by-invertase-immobilized-onto-magnetic-diatomaceous-earth-nanoparticles
#13
Mariana P Cabrera, Caio R D Assis, David F M Neri, Claudete F Pereira, Fernando Soria, Luiz B Carvalho
Invertase immobilized on magnetic diatomaceous earth nanoparticles (mDE-APTES-invertase) with high sucrolytic activity was obtained by an easy and low-cost method. An experimental design was carried out to investigate the best immobilization conditions and it allowed obtaining an immobilized derivative with a residual specific activity equal to 92.5%. Then, a second experimental design selected the mDE-APTES-invertase with higher specific activity in relation to other derivatives reported in the literature (2...
March 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28476164/wnt-beta-catenin-pathway-modulating-anticancer-immune-response
#14
REVIEW
Sachin Gopalkrishna Pai, Benedito A Carneiro, Jose Mauricio Mota, Ricardo Costa, Caio Abner Leite, Romualdo Barroso-Sousa, Jason Benjamin Kaplan, Young Kwang Chae, Francis Joseph Giles
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus...
May 5, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28469938/aqueous-vascular-endothelial-growth-factor-and-clinical-outcomes-correlation-after-single-intravitreal-injection-of-bevacizumab-in-patients-with-neovascular-age-related-macular-degeneration
#15
Thiago Cabral, Luiz H Lima, Júlia Polido, Jimmy Duong, Érika Okuda, Akiyoshi Oshima, Pedro Serracarbassa, Caio V Regatieri, Rubens Belfort
PURPOSE: To evaluate the concentration of vascular endothelial growth factor (VEGF) in aqueous humor after a single intravitreal injection of bevacizumab (IVB) in eyes with neovascular age-related macular degeneration (AMD). METHODS: In this prospective interventional case series study, 24 eyes of 24 patients with types 1 and 2 choroidal neovascularization secondary to neovascular AMD were treated with a single intravitreal injection of bevacizumab. Aqueous humor samples were obtained before the intravitreal injection and at one week, one month, and three months follow-up periods...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28459655/comparative-analyses-of-zebrafish-anxiety-like-behavior-using-conflict-based-novelty-tests
#16
Elana V Kysil, Darya A Meshalkina, Erin E Frick, David J Echevarria, Denis B Rosemberg, Caio Maximino, Monica Gomes Lima, Murilo S Abreu, Ana C Giacomini, Leonardo J G Barcellos, Cai Song, Allan V Kalueff
Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in neuroscience research and central nervous system (CNS) drug discovery. Representing the most commonly used zebrafish anxiety models, the novel tank test (NTT) focuses on zebrafish diving in response to potentially threatening stimuli, whereas the light-dark test (LDT) is based on fish scototaxis (innate preference for dark vs. bright areas). Here, we systematically evaluate the utility of these two tests, combining meta-analyses of published literature with comparative in vivo behavioral and whole-body endocrine (cortisol) testing...
June 2017: Zebrafish
https://www.readbyqxmd.com/read/28450867/p2x7-receptor-in-bone-marrow-derived-cells-aggravates-tuberculosis-caused-by-hypervirulent-mycobacterium-bovis
#17
Caio César Barbosa Bomfim, Eduardo Pinheiro Amaral, Alexandra Dos Anjos Cassado, Érika Machado Salles, Rogério Silva do Nascimento, Elena Lasunskaia, Mario Hiroyuki Hirata, José Maria Álvarez, Maria Regina D'Império-Lima
Tuberculosis (TB) remains a serious public health problem despite the great scientific advances in the recent decades. We have previously shown that aggressive forms of TB caused by hypervirulent strains of Mycobacterium tuberculosis and Mycobacterium bovis are attenuated in mice lacking the P2X7 receptor, an ion channel activated by extracellular ATP. Therefore, P2X7 receptor is a potential target for therapeutic intervention. In vitro, hypervirulent mycobacteria cause macrophage death by a P2X7-dependent mechanism that facilitates bacillus dissemination...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28444099/association-of-the-protein-tyrosine-phosphatase-non-receptor-22-polymorphism-ptpn22-with-endometriosis-a-meta-analysis
#18
Noel Pabalan, Hamdi Jarjanazi, Denise Maria Christofolini, Bianca Bianco, Caio Parente Barbosa
Objective: To evaluate PTPN22 C1858T polymorphism and the risk of endometriosis. Methods: A meta-analysis of 10 published case-control studies (from four articles), with a total sample of 971 cases and 1,181 controls, was performed. We estimated risk (odds ratio and 95% confidence intervals) of endometriosis associations with the C1858T polymorphism. Results: A significant increased risk in all genetic models of the variant T allele with endometriosis (odds ratio: 3...
January 2017: Einstein
https://www.readbyqxmd.com/read/28443965/prognosis-determinants-after-cardioverter-defibrillators-implantation-in-brazil
#19
Arn Migowski, Regina Maria de Aquino Xavier, Katia Regina da Silva, Caio Marcos de Moraes Albertini, Elizabeth Sartori Crevelari, Eduardo Infante Januzzi de Carvalho, Alfredo Inácio Fiorelli, Martino Martinelli Filho, Roberto Costa
No abstract text is available yet for this article.
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28441788/hsp27-and-hsp70-expression-in-esophageal-squamous
#20
Caio Cesar Floriano Luz, Juliana Noguti, Leandro Borges de Araújo, Mara Silva Dos Santos Gianni, Thiago Simão Gomes, Artigiani Neto Ricardo
Twenty-eight specimens of Esophael squamous cell carcinoma (ESCC) were obtained by surgery procedures.The tissues were fixed in formalin and embedded in paraffin. In each case, all available hematoxylin and eosin stained sections were examined and a representative block was selected. The ages of these patients ranged from 40 to 93 years, with a mean age of 60 years. Results. The histological grade of tumors was 4 well-differentiated, 19 moderately differentiated and 5 poorly differentiated. Expression of Hsp27 and Hsp70 in ESCC was demonstrated in 23 (82,14%) and 26 (92,86%) cases, respectively...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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