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https://www.readbyqxmd.com/read/29140377/influence-of-the-prosthetic-index-on-fracture-resistance-of-morse-taper-dental-implants
#1
Karla Zancopé, Caio César Dias Resende, Carolina Guimarães Castro, Rafael Calixto Salatti, Flávio Domingues das Neves
PURPOSE: Manufacturers have inserted a prosthetic index, an internal hexagon to guide prosthetic components inside Morse taper implants. However, it is still unclear if this mechanism could decrease the mechanical strength of Morse taper implants. The aim of this study was to evaluate the influence of the prosthetic index inside Morse taper implants on fracture resistance compared with nonindexed implants. MATERIALS AND METHODS: Fifty-seven Morse taper implants, with 11...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29135604/chemical-burns-of-the-eye-the-role-of-retinal-injury-and-new-therapeutic-possibilities
#2
Claes H Dohlman, Fabiano Cade, Caio V Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie-Claude Robert, George N Papaliodis, Dongfeng Chen, James V Aquavella, Esen K Akpek, Anthony J Aldave, Kimberly C Sippel, Donald J DʼAmico, Jan G Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q Shen, Miguel González-Andrades, James Chodosh, Kenneth R Kenyon, C Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A Colby, Joseph B Ciolino, Demetrios G Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I Paschalis
PURPOSE: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. METHODS: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. RESULTS: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29117195/biological-and-phylogenetic-characteristics-of-west-african-lineages-of-west-nile-virus
#3
Gamou Fall, Nicholas Di Paola, Martin Faye, Moussa Dia, Caio César de Melo Freire, Cheikh Loucoubar, Paolo Marinho de Andrade Zanotto, Ousmane Faye, Amadou Alpha Sall
The West Nile virus (WNV), isolated in 1937, is an arbovirus (arthropod-borne virus) that infects thousands of people each year. Despite its burden on global health, little is known about the virus' biological and evolutionary dynamics. As several lineages are endemic in West Africa, we obtained the complete polyprotein sequence from three isolates from the early 1990s, each representing a different lineage. We then investigated differences in growth behavior and pathogenicity for four distinct West African lineages in arthropod (Ap61) and primate (Vero) cell lines, and in mice...
November 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29114357/heterochromatin-variation-and-line-1-distribution-in-artibeus-chiroptera-phyllostomidae-from-central-amazon-brazil
#4
Érica Martinha Silva de Souza, Maria Claudia Gross, Carlos Eduardo Faresin E Silva, Cibele Gomes Sotero-Caio, Eliana Feldberg
Species in the subgenus Artibeus Leach, 1821 are widely distributed in Brazil. Conserved karyotypes characterize the group with identical diploid number and chromosome morphology. Recent studies suggested that the heterochromatin distribution and accumulation patterns can vary among species. In order to assess whether variation can also occur within species, we have analyzed the chromosomal distribution of constitutive heterochromatin in A. planirostris (Spix, 1823) and A. lituratus (Olfers, 1818) from Central Amazon (North Brazil) and contrasted our findings with those reported for other localities in Brazil...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/29107383/alteration-in-ikaros-expression-promotes-b-1-cell-differentiation-into-phagocytes
#5
Vivian Cristina de Oliveira, Ana Clara Pires Sodré, Caio Perez Gomes, Nilmar Silvio Moretti, João Bosco Pesquero, Ana Flavia Popi
Ikaros is a broad transcription factor pointed as a critical regulator of lymphocyte development. Recent reports have emphasized that distinct isoforms of Ikaros control the dichotomy of the hematopoietic system into lymphoid and myeloid lineages. In addition, expression of dominant-negative isoforms of Ikaros is linked to abnormal hematopoiesis, which could culminate in hematological disorders due to loss of function of the protein. B-1 cells are an intriguing subtype of B-lymphocytes that preserves some myeloid characteristics...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29107249/a-chitin-binding-lectin-from-moringa-oleifera-seeds-wsmol-impairs-the-digestive-physiology-of-the-mediterranean-flour-larvae-anagasta-kuehniella
#6
Caio Fernando Ramalho de Oliveira, Maiara Celine de Moura, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Luana Cassandra Breitenbach Barroso Coelho, Maria Lígia Rodrigues Macedo
Biotechnological techniques allow the investigation of alternatives to outdated chemical insecticides for crop protection; some investigations have focused on the identification of molecules tailored from nature for this purpose. We, herein, describe the negative effects of water-soluble lectin from Moringa oleifera seeds (WSMoL) on Anagasta kuehniella development. The chitin-binding lectin, WSMoL, impaired the larval weight gain by 50% and affected the activity of the pest's major digestive enzymes. The commitment of the digestive process became evident after controlled digestion studies, where the capacity of protein digestion was compromised by >90%...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29100249/longer-telomere-length-in-elite-master-sprinters-relationship-to-performance-and-body-composition
#7
Herbert Gustavo Simoes, Caio Victor Sousa, Thiago Dos Santos Rosa, Samuel da Silva Aguiar, Lysleine Alves Deus, Erica Carine Campos Caldas Rosa, Angelica Amorim Amato, Rosangela Vieira Andrade
Emergent evidence suggests that the long-term healthy lifestyle of master athletes may attenuate aging. We compared telomere length (TL) of high-level master sprinters and non-athlete age-matched controls, and analyzed the relationships of TL with performance and body fat. Elite master sprinters (n=11; aged 50.1±9.2yrs) and healthy untrained controls (n=10; aged 45.4±10.9yrs) had blood samples collected for biochemical and biomolecular analyses. Master sprinters had longer TL, lower body fat and BMI, and a better lipid profile than age-matched controls (p<0...
November 3, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29091147/progesterone-level-on-the-day-of-hcg-administration-in-relation-to-the-pregnancy-rates-of-patients-undergoing-assisted-reproduction-techniques
#8
Renato de Oliveira, Fernanda Godoy Cabral, Waldemar de Almeida Pereira Carvalho, Emerson Barchi Cordts, Bianca Bianco, Caio Parente Barbosa
OBJECTIVE: To evaluate the predictive capacity for pregnancy of the progesterone level on the day of administering human chorionic gonadotropin, in women submitted to assisted reproductive techniques. METHODS: An observational study with 914 women submitted to assisted reproductive techniques from August 2014 to June 2016. RESULTS: Total pregnancy rate was 34.58%; in that, the pregnancy rate in women <35 years, between 35 and 38, and >38 years was, respectively, 42...
July 2017: Einstein
https://www.readbyqxmd.com/read/29091146/how-polymorphic-markers-contribute-to-genetic-diseases-in-different-populations-the-study-of-inhibin-a-for-premature-ovarian-insufficiency
#9
Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, Bianca Bianco, Caio Parente Barbosa
OBJECTIVE: To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. METHODS: A 5mL sample of peripheral blood was collected from all study participants in an EDTA tube and was used for DNA extraction. For the patient group, 5mL of blood were also collected in a tube containing heparin for karyotype, and 5mL were collected in a dry tube for follicle stimulant hormone dosage...
July 2017: Einstein
https://www.readbyqxmd.com/read/29064656/stage-effect-of-chronic-kidney-disease-in-erectile-function
#10
Márcio Rodrigues Costa, Viviane Campos Ponciano, Théo Rodrigues Costa, Caio Pereira Gomes, Enio Chaves de Oliveira
PURPOSE: The study aims to assess the influence of the stage of chronic kidney disease and glomerular filtration rate on prevalence and degree of erectile dysfunction. MATERIALS AND METHODS: This transversal study, conducted from May 2013 to December 2015, included patients with chronic kidney disease in conservative treatment, stages III/IV/V. Erectile dysfunction was evaluated by the International Index of Erectile Function. Data classically associated with erectile dysfunction were obtained by medical record review...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29062816/fat-embolism-syndrome-in-femoral-shaft-fractures-does-the-initial-treatment-make-a-difference
#11
Jânio José Alves Bezerra Silva, Diogo de Almeida Diana, Victor Eduardo Roman Salas, Caio Zamboni, José Soares Hungria Neto, Ralph Walter Christian
OBJECTIVE: To identify the risk factors correlated with the initial treatment performed. METHODS: This is a retrospective study involving a total of 272 patients diagnosed with femoral shaft fractures. Of the patients, 14% were kept at rest until the surgical treatment, 52% underwent external fixation, 10% received immediate definitive treatment, and 23% remained in skeletal traction (23%) until definitive treatment. RESULTS: There were six cases of fat embolism syndrome (FES), which showed that polytrauma is the main risk factor for its development and that initial therapy was not important...
September 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29062813/traumatic-anterior-instability-of-the-shoulder
#12
João Roberto Polydoro Rosa, Caio Santos Checchia, Alberto Naoki Miyazaki
The shoulder is the most unstable joint in the human body. Traumatic anterior instability of the shoulder is a common condition, which, especially in young patients, is associated with high recurrence rates. The effectiveness of non-surgical treatments when compared to surgical ones is still controversial. The purpose of this study was to review the literature for current concepts and updates regarding the treatment of this condition.
September 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29054358/a-comparative-study-of-warheads-for-design-of-cysteine-protease-inhibitors
#13
Daniel G Silva, Jean F R Ribeiro, Daniela De Vita, Lorenzo Cianni, Caio Haddad Franco, Lucio H Freitas-Junior, Carolina Borsoi Moraes, Josmar R Rocha, Antonio C B Burtoloso, Peter W Kenny, Andrei Leitão, Carlos A Montanari
The effects on potency of cruzain inhibition of replacing a nitrile group with alternative warheads were explored. The oxime was almost an order of magnitude more potent than the corresponding nitrile and has the potential to provide access to the prime side of the catalytic site. Dipeptide aldehydes and azadipeptide nitriles were found to be two orders of magnitude more potent cruzain inhibitors than the corresponding dipeptide nitriles although potency differences were modulated by substitution at P1 and P3...
November 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29048606/contact-location-and-neuropsychological-outcomes-in-subthalamic-deep-brain-stimulation
#14
Darlene P Floden, Caio M Matias, Connor A Wathen, Grace E Ozinga, Olivia Hogue, Andre G Machado
BACKGROUND: A host of influences contribute to cognitive and behavioral changes following deep brain stimulation. The location of the active cathode is likely an important variable but it has received little attention. OBJECTIVE: To determine whether active contact location relative to the subthalamic nucleus and other neighboring structures is related to nonmotor outcomes. METHODS: We identified a retrospective, cross-sectional sample of 46 patients who underwent subthalamic nucleus deep brain stimulation for treatment of idiopathic Parkinson's disease...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29046640/antiparkinsonian-efficacy-of-guanosine-in-rodent-models-of-movement-disorder
#15
Caio M Massari, Marc López-Cano, Fabiana Núñez, Víctor Fernández-Dueñas, Carla I Tasca, Francisco Ciruela
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29043211/native-valve-endocarditis-caused-by-achromobacter-xylosoxidans-a-case-report-and-review-of-literature
#16
Caio Godoy Rodrigues, Jairo Rays, Marcia Yoshie Kanegae
Achromobacter xylosoxidans is a Gram-negative aerobic bacterium first described by Yabuuchi and Ohyama in 1971. A. xylosoxidans is frequently found in aquatic environments. Abdominal, urinary tract, ocular, pneumonia, meningitis, and osteomyelitis are the most common infections. Infective endocarditis is rare. As far as we know, until now, only 19 cases have been described, including this current report. We report the case of community-acquired native valve endocarditis caused by A. xylosoxidans in an elderly patient without a concomitant diagnosis of a malignancy or any known immunodeficiency...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29027987/chromosomal-evolution-in-chiroptera
#17
REVIEW
Cibele G Sotero-Caio, Robert J Baker, Marianne Volleth
Chiroptera is the second largest order among mammals, with over 1300 species in 21 extant families. The group is extremely diverse in several aspects of its natural history, including dietary strategies, ecology, behavior and morphology. Bat genomes show ample chromosome diversity (from 2n = 14 to 62). As with other mammalian orders, Chiroptera is characterized by clades with low, moderate and extreme chromosomal change. In this article, we will discuss trends of karyotypic evolution within distinct bat lineages (especially Phyllostomidae, Hipposideridae and Rhinolophidae), focusing on two perspectives: evolution of genome architecture, modes of chromosomal evolution, and the use of chromosome data to resolve taxonomic problems...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29021086/genomic-characterization-of-an-extensively-drug-resistant-kpc-2-producing-klebsiella-pneumoniae-st855-cc258-only-susceptible-to-ceftazidime-avibactam-isolated-in-brazil
#18
Caio Augusto Martins Aires, Michael J Rybak, Juwon Yim, Polyana Silva Pereira, Cláudio M Rocha-de-Souza, Rodolpho Mattos Albano, Valdelucia Oliveira Cavalcanti, Ana Paula D'Alincourt Carvalho-Assef, Marisa Zenaide Ribeiro Gomes, Marise Dutra Asensi
In this study, we describe the genetic features of an XDR KPC-2-producing Klebsiella pneumoniae isolate by using whole-genome sequencing, its clinical-epidemiological context and susceptibility against antimicrobial combinations. The isolate belongs to clonal complex 258 and harbors several acquired genes and mutations associated with antimicrobial resistance.
August 25, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29018811/high-frequency-eeg-variations-in-children-with-autism-spectrum-disorder-during-human-faces-visualization
#19
Celina A Reis Paula, Camille Reategui, Bruna Karen de Sousa Costa, Caio Queiroz da Fonseca, Luana da Silva, Edgard Morya, Fabricio Lima Brasil
Autism spectrum disorder (ASD) is a neuropsychiatric disorder characterized by the impairment in the social reciprocity, interaction/language, and behavior, with stereotypes and signs of sensory function deficits. Electroencephalography (EEG) is a well-established and noninvasive tool for neurophysiological characterization and monitoring of the brain electrical activity, able to identify abnormalities related to frequency range, connectivity, and lateralization of brain functions. This research aims to evidence quantitative differences in the frequency spectrum pattern between EEG signals of children with and without ASD during visualization of human faces in three different expressions: neutral, happy, and angry...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29018774/influenza-a-virus-as-a-predisposing-factor-for-cryptococcosis
#20
Lorena V N Oliveira, Marliete C Costa, Thaís F F Magalhães, Rafael W Bastos, Patrícia C Santos, Hellem C S Carneiro, Noelly Q Ribeiro, Gabriella F Ferreira, Lucas S Ribeiro, Ana P F Gonçalves, Caio T Fagundes, Marcelo A Pascoal-Xavier, Julianne T Djordjevic, Tania C Sorrell, Daniele G Souza, Alexandre M V Machado, Daniel A Santos
Influenza A virus (IAV) infects millions of people annually and predisposes to secondary bacterial infections. Inhalation of fungi within the Cryptococcus complex causes pulmonary disease with secondary meningo-encephalitis. Underlying pulmonary disease is a strong risk factor for development of C. gattii cryptococcosis though the effect of concurrent infection with IAV has not been studied. We developed an in vivo model of Influenza A H1N1 and C. gattii co-infection. Co-infection resulted in a major increase in morbidity and mortality, with severe lung damage and a high brain fungal burden when mice were infected in the acute phase of influenza multiplication...
2017: Frontiers in Cellular and Infection Microbiology
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