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Sofia Palacio, Peter J Hosein, Isildinha Reis, Ikechukwu I Akunyili, Vinicius Ernani, Terri Pollack, Jessica Macintyre, Maria H Restrepo, Jaime R Merchan, Caio M Rocha Lima
The phase III MPACT trial for metastatic pancreatic cancer (PC) showed improved overall survival (OS), progression free survival (PFS) and response rates (RRs) for first-line nab -paclitaxel (Abraxane) and gemcitabine (the AG combination) compared to gemcitabine monotherapy. The safety and efficacy of the AG combination has not been systematically studied as second-line therapy or beyond for metastatic PC. We conducted an IRB-approved retrospective analysis of all patients diagnosed between September 2010 and August 2014 with advanced refractory PC that received combination treatment with AG at our institution...
February 2018: Journal of Gastrointestinal Oncology
Fabricio Castro Machado, Caio Haddad Franco, Jose Vitorino Dos Santos Neto, Karina Luiza Dias-Teixeira, Carolina Borsoi Moraes, Ulisses Gazos Lopes, Bertal Huseyin Aktas, Sergio Schenkman
Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome multiplication by also affecting the phosphorylation of eIF2 alpha subunit (eIF2α), we tested 25 analogs of 1,3-diarylureas and cHAUs against Trypanosoma cruzi, the agent of Chagas disease. One of them (I-17) presented selectivity close to 10-fold against the insect replicative forms and also inhibited the multiplication of T...
March 20, 2018: Scientific Reports
Érica Lofrano Reghine, Caio César Inaco Cirino, André Amate Neto, Fabiana Rossi Varallo, Paulo Roberto Barbosa Évora, Tales Rubens de Nadai
BACKGROUND Kirschner wires are often used to perform osteosynthesis. Migration through tissue of these wires is a rare but well-known occurrence. CASE REPORT A 65-year-old female presented with light intensity pain complaints in the upper left chest area; personal history included left clavicle fracture 20 years ago that was treated surgically with fixation using a K-wire. Chest radiography showed the presence of metallic foreign body in the left pulmonary apex. An exploratory axillary thoracotomy was performed, and the foreign body was extracted by a pneumotomy...
March 21, 2018: American Journal of Case Reports
Samuel Silva Aguiar, Caio Victor Sousa, Herbert Gustavo Simões, Rodrigo Vanerson Passos Neves, Fernando Costa, Michel Kendy Souza, Milton Moraes, Jonato Prestes, Marcelo Magalhães Sales, Anderson Sola Haro, Jeffrey Michael Willardson, Thiago Dos Santos Rosa
Resistance exercise (RE) can be an excellent modality for glycemic control. Studies have demonstrated that a single RE session can reduce glycemia in subjects with or without diabetes. Little is known about the dose-response effect of RE on glycemic control. This study aimed to investigate the acute metabolic responses after different RE protocols. Eighty-nine men were separated into six groups that completed RE protocols: two sets of 18 repetitions (2x18 at 50% of 1RM; n=19); three sets of 12 repetitions (3x12 at 70% of 1RM; n=14); four sets of nine repetitions (4x9 at 80% of 1RM; n=13); six sets of six repetitions (6x6 at 90% of 1RM; n=19); circuit (2x18 at 50% of 1RM; n=12); and a control session (n=12)...
March 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Bruno Bertoli Esmanhotto, Caio Pellizzari, James Henrique Yared
No abstract text is available yet for this article.
March 16, 2018: Acta Neurologica Belgica
Caio M Moreira, Max Rollwage, Kristin Kaduk, Melanie Wilke, Igor Kagan
Humans and other animals constantly evaluate their decisions in order to learn and behave adaptively. Experimentally, such evaluation processes are accessed using metacognitive reports made after decisions, typically using verbally formulated confidence scales. When subjects report high confidence, it reflects a high certainty of being correct, but a low confidence might signify either low certainty about the outcome, or a high certainty of being incorrect. Hence, metacognitive reports might reflect not only different levels of decision certainty, but also two certainty directions (certainty of being correct and certainty of being incorrect)...
March 12, 2018: Cognition
Eduardo M Rocha, Monica Alves, João Marcello Furtado, Caio Regatieri
No abstract text is available yet for this article.
January 2018: Arquivos Brasileiros de Oftalmologia
Tulio Diniz-Fernandes, Alexandre Leme Godoy-Santos, Maria Cristina Santo, Pedro Pontin, Caio Augusto Alves Pereira, Yuri Justi Jardim, Ana Paula Pereira Velosa, Nicola Maffulli, Walcy Rosolia Teodoro, Vera Luiza Capelozzi
Posterior tibial tendinopathy (PTT) can lead to acquired flatfoot in adults. Many patients develop PTT without any identifiable risk factors. Molecular changes in extracellular matrix (ECM) and matrix metalloproteinase (MMP) polymorphism may influence the risk of developing PTT. We aim to investigate the association between matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms with changes in collagen I, III and V in PTT. A case-control study with 22 patients and 5 controls was performed. The MMP-1 (2G/2G) and MMP-8 (T/T) genotypes were determined by PCR-restriction fragment length polymorphism...
March 13, 2018: Histology and Histopathology
Brenda de Oliveira da Silva, Luciane Carla Alberici, Letícia Ferreira Ramos, Caio Mateus Silva, Marina Bonfogo da Silveira, Carlos R P Dechant, Scott L Friedman, Kumiko Koibuchi Sakane, Letícia Rocha Gonçalves, Karen C M Moraes
The development of new therapeutic strategies to control or reverse hepatic fibrosis requires thorough knowledge about its molecular and cellular basis. It is known that the heptapeptide angiotensin-(1-7) [ang-(1-7)] can reduce hepatic fibrosis and steatosis in vivo; therefore, it is important to uncover the mechanisms regulating its activity and cellular model of investigation. Ang-(1-7) is a peptide of the renin-angiotensin system (RAS), and here we investigated its modulatory effect on the expression pattern of microRNAs (miRNAs) in hepatic stellate cells (HSCs) LX-2, which transdifferentiate into fibrogenic and proliferative cells...
March 7, 2018: International Journal of Biochemistry & Cell Biology
Louyse D Correia, Caio C Silva de Castro
No abstract text is available yet for this article.
March 8, 2018: International Journal of Dermatology
Andressa Dos Santos Barbosa Ortega, Luciane Alves Maranho, Caio Rodrigues Nobre, Beatriz Barbosa Moreno, Rafael Solé Guimarães, Daniel Temponi Lebre, Denis Moledo de Souza Abessa, Daniel Araki Ribeiro, Camilo Dias Seabra Pereira
The presence of cocaine and its metabolites and by-products has been identified in different aquatic matrices, making crack cocaine the target of recent studies. The aim of this study was to evaluate the sublethal effects of crack on the brown mussel Perna perna. Mussels were exposed to three concentrations of crack cocaine (0.5, 5.0, and 50.0 μg L-1 ) for 168 h. Gills, digestive glands, and hemolymph were extracted and analyzed after three different exposure times using a suite of biomarkers (EROD, DBF, GST, GPX, LPO, DNA damage, ChE, and lysosomal membrane stability [LMS])...
March 8, 2018: Environmental Science and Pollution Research International
Caio Mauricio Mendes de Cordova, Ernani Tiarajú de Santa Helena, Caroline Galgowski, Vitor Holmo Figueira, Gabrielle Bortoli Setter, Marcello Ricardo Paulista Markus, Carsten Oliver Schmidt, Henry Völzke, Till Ittermann
A simple equation established by Cordova & Cordova (LDL-COR) was developed to provide an improved estimation of LDL-cholesterol in a large Brazilian laboratory database. We evaluated this new equation in a general population cohort in Pomerania, north-eastern Germany (SHIP Study) compared to other existing formulas (Anandaraja, Teerakanchana, Chen, Hattori, Martin, Friedewald and Ahmadi), and its power in the prediction of death by atherosclerosis related events as the primary outcome. Analysis was conducted on a cohort of 4075 individuals considering age, gender, use of lipid lowering therapy and associated co-morbidities such as diabetes, hepatic, kidney and thyroid disease...
March 8, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
Caio E G Reis, Cicília L R Dos S Paiva, Angélica A Amato, Adriana Lofrano-Porto, Sara Wassell, Leslie J C Bluck, José G Dórea, Teresa H M da Costa
Epidemiological studies have found coffee consumption is associated with a lower risk for type 2 diabetes mellitus, but the underlying mechanisms remain unclear. Thus, the aim of this randomised, cross-over single-blind study was to investigate the effects of regular coffee, regular coffee with sugar and decaffeinated coffee consumption on glucose metabolism and incretin hormones. Seventeen healthy men participated in five trials each, during which they consumed coffee (decaffeinated, regular (containing caffeine) or regular with sugar) or water (with or without sugar)...
March 8, 2018: British Journal of Nutrition
Daniela Atili Brandini, Marina Fuzette Amaral, Caio Vinícius Lourenço Debortoli, Sônia Regina Panzarini
The aim of this study is to evaluate the action of paramonochlorophenol associated with Furacin followed by calcium hydroxide (CH) dressing in the control of inflammatory root resorption in cases of immediate tooth replantation with delayed endodontic treatment. A total of 28 incisors of 3 male dogs were extracted and replanted after 15 minutes, and randomly divided into 3 groups: Group I (n = 8) - endodontic treatment was performed before the extraction and replantation; Group II (n = 10) - endodontic treatment was performed 30 days after replantation and the root canal was filled with CH dressing; Group III (n = 10) - endodontic treatment was performed 30 days after replantation and root canals received temporary medication of paramonochlorophenol-Furacin followed by CH dressing...
March 1, 2018: Brazilian Oral Research
Pantelis T Nikolaidis, Caio V de Sousa, Beat Knechtle
In open-water swimming events with non-elite swimmers held in the USA, but not in Europe, women were faster than men. We examined the sex difference in elite long-distance open-water swimming races and the role of nationality by investigating 7,468 swimmers competing in 5 km, 10 km and 25 km FINA races held between 2000 and 2016. More men participated in 10 km and 25 km than in 5km races. Men were faster than women and the sex difference was similar in all race distances. Swimming speed was faster for 5km than for 10km, which in turn was faster than 25km...
March 6, 2018: Research in Sports Medicine
Pantelis Theodoros Nikolaidis, Caio Victor Sousa, Beat Knechtle
Aim: The aim of the present study was to investigate the relationship of wearing a wetsuit with sex, age group, nationality, calendar year, and performance in crossing the "Strait of Gibraltar"(14.3 km). Materials and methods: A sample of 1,130 open-water (females, n=180, age 35.9±11.9 years; males, n=950, age 40.0±10.2 years) ultra-distance swimmers crossing the "Strait of Gibraltar" since 1950 was analyzed. Results: Male, older, and Spanish swimmers used wetsuits more often than female, younger, and athletes of other nationalities, respectively, and the use of the wetsuit has increased during the past three decades...
2018: Open Access Journal of Sports Medicine
Caio H Mazucanti, Elisa M Kawamoto, Mark P Mattson, Cristoforo Scavone, Simonetta Camandola
Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function. Although highly expressed in specific areas of the brain, Klotho functions in the central nervous system remain unknown. Here, we show that cultured hippocampal neurons respond to insulin and glutamate stimulation by elevating Klotho protein levels. Conversely, AMPA and NMDA antagonism suppress neuronal Klotho expression. We also provide evidence that soluble Klotho enhances astrocytic aerobic glycolysis by hindering pyruvate metabolism through the mitochondria, and stimulating its processing by lactate dehydrogenase...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Marina Viegas Moura Rezende Ribeiro, João Vitor de Omena Jucá, Anna Luyza Correia Dos Santos Alves, Caio Victor Oliveira Ferreira, Fabiano Timbó Barbosa, Êurica Adélia Nogueira Ribeiro
Hemoglobinopathies are a group of hereditary diseases that cause quantitative or qualitative changes in the shape, function or synthesis of hemoglobin. One of the most common is sickle cell anemia, which, due to sickling of erythrocytes, causes vaso-occlusive phenomena. Among the possible ocular manifestations, the most representative is retinopathy, which can lead to blindness if left untreated. Therefore, periodic ophthalmologic monitoring of these patients is important for early diagnosis and adequate therapeutic management, which can be done localy by treating the lesions in the eyes, or systemically...
December 2017: Revista da Associação Médica Brasileira
Luana Carvalho Cezar, Thiago Berti Kirsten, Caio Cesar Navarrete da Fonseca, Ana Paula Nascimento de Lima, Maria Martha Bernardi, Luciano Freitas Felicio
Autism is characterized by numerous behavioral impairments, such as in communication, socialization and cognition. Recent studies have suggested that valproic acid (VPA), an anti-epileptic drug with teratogenic activity, is related to autism. In rodents, VPA exposure during pregnancy induces autistic-like effects. Exposure to VPA may alter zinc metabolism resulting in a transient deficiency of zinc. Therefore, we selected zinc as a prenatal treatment to prevent VPA-induced impairments in a rat model of autism...
February 23, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Thaísa Godinho da Encarnação, Camila Cabral Portugal, Caio Eduardo Nogueira, Felipe Nascimento Santiago, Renato Socodato, Roberto Paes-de-Carvalho
Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neurotransmitter dopamine (DA), acting through D1 - and D2 -like receptor subfamilies and classically coupled to adenylyl cyclase, is known to modulate synaptic transmission in the retina. Here, we reveal that DA controls the release of ascorbate from retinal neurons...
February 23, 2018: Molecular Neurobiology
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