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https://www.readbyqxmd.com/read/29328472/combined-analysis-of-gene-expression-and-genome-binding-profiles-identified-potential-therapeutic-targets-of-ciclopirox-in-ewing-sarcoma
#1
Baisheng Yuan, Wei Ji, Haipeng Xia, Jianmin Li
Ciclopirox (CPX) is a synthetic antifungal drug that is mainly used to treat dermatomycoses. The aim of the present study was to determine whether CPX could influence Ewing sarcoma progression. The present study suggested that CPX treatment may inhibit Ewing sarcoma (ES) progression through Ewing sarcoma breakpoint region 1‑Friend leukemia integration 1 (EWS‑FLI1), a common fusion transcript structure in patients with ES. To determine the underlying mechanisms of ES progression, cross analysis was conducted on three high‑throughput genome or transcript me datasets from the Gene Expression Omnibus...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29319370/association-between-cd226-polymorphism-and-soluble-levels-in-rheumatoid-arthritis-relationship-with-clinical-activity
#2
Youssef M Mosaad, Ehab Es El-Toraby, Ziyad Me Tawhid, Adel I Abdelsalam, Asmaa F Enin, Amany Me Hasson, Ghada M Shafeek
OBJECTIVE: To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS: The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism was typed by PCR-RFLP for 112 RA patients and 100 healthy controls. RESULTS: Significant association with RA was found with CD226 T allele (OR (95%CI) = 1...
April 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29298051/crispred-macrophages-for-cell-based-cancer-immunotherapy
#3
Moumita Ray, Yi-Wei Lee, Joseph Hardie, Rubul Mout, Gulen Yeşilbag Tonga, Michelle E Farkas, Vincent M Rotello
We present here an integrated nanotechnology/biology strategy for cancer immunotherapy that uses arginine nanoparticles (ArgNPs) to deliver CRISPR-Cas9 gene editing machinery into cells to generate SIRP-α knockout macrophages. The NP system efficiently codelivers single guide RNA (sgRNA) and Cas9 protein required for editing to knock out the "don't eat me signal" in macrophages that prevents phagocytosis of cancer cells. Turning off this signal increased the innate phagocytic capabilities of the macrophages by 4-fold...
February 21, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28859545/acute-cardiorespiratory-perceptual-and-enjoyment-responses-to%C3%A2-high-intensity-interval-exercise-in-adolescents
#4
Adam A Malik, Craig A Williams, Bert Bond, Kathryn L Weston, Alan R Barker
This study aimed to examine adolescents' acute cardiorespiratory and perceptual responses during high-intensity interval exercise (HIIE) and enjoyment responses following HIIE and work-matched continuous moderate intensity exercise (CMIE). Fifty-four 12- to 15-year olds (27 boys) completed 8 × 1-min cycling at 90% peak power with 75-s recovery (HIIE) and at 90% of the gas exchange threshold (CMIE). Absolute oxygen uptake ([Formula: see text]), percentage of maximal [Formula: see text] (%[Formula: see text]), heart rate (HR), percentage of maximal HR (%HRmax) and ratings of perceived exertion (RPE) were collected during HIIE...
August 31, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28690965/fabrication-of-hierarchically-porous-tio2-nanofibers-by-microemulsion-electrospinning-and-their-application-as-anode-material-for-lithium-ion-batteries
#5
Jin Zhang, Yibing Cai, Xuebin Hou, Xiaofei Song, Pengfei Lv, Huimin Zhou, Qufu Wei
Titanium dioxide (TiO2) nanofibers have been widely applied in various fields including photocatalysis, energy storage and solar cells due to the advantages of low cost, high abundance and nontoxicity. However, the low conductivity of ions and bulk electrons hinder its rapid development in lithium-ion batteries (LIB). In order to improve the electrochemical performances of TiO2 nanomaterials as anode for LIB, hierarchically porous TiO2 nanofibers with different tetrabutyl titanate (TBT)/paraffin oil ratios were prepared as anode for LIB via a versatile single-nozzle microemulsion electrospinning (ME-ES) method followed by calcining...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27863207/effects-of-morning-versus-evening-combined-strength-and-endurance-training-on-physical-performance-muscle-hypertrophy-and-serum-hormone-concentrations
#6
RANDOMIZED CONTROLLED TRIAL
Maria Küüsmaa, Moritz Schumann, Milan Sedliak, William J Kraemer, Robert U Newton, Jari-Pekka Malinen, Kai Nyman, Arja Häkkinen, Keijo Häkkinen
This study investigated the effects of 24 weeks of morning versus evening same-session combined strength (S) and endurance (E) training on physical performance, muscle hypertrophy, and resting serum testosterone and cortisol diurnal concentrations. Forty-two young men were matched and assigned to a morning (m) or evening (e) E + S or S + E group (mE + S, n = 9; mS + E, n = 9; eE + S, n = 12; and eS + E, n = 12). Participants were tested for dynamic leg press 1-repetition maximum (1RM) and time to exhaustion (Texh) during an incremental cycle ergometer test both in the morning and evening, cross-sectional area (CSA) of vastus lateralis and diurnal serum testosterone and cortisol concentrations (0730 h; 0930 h; 1630 h; 1830 h)...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27392611/impact-of-the-intermediary-layer-on-sealant-retention-a-randomized-24-month-clinical-trial
#7
Kelly Maria Silva Moreira, Kamila Rosamilia Kantovitz, Juliana Pedrini Dias Aguiar, Ana Flávia Sanches Borges, Fernanda Miori Pascon, Regina Maria Puppin-Rontani
OBJECTIVES: The aims of this study were to assess long-term impact of tooth eruption stages (ES) on sealant retention on occlusal surfaces previously coated with intermediary bonding layer and to determine caries prevention. MATERIALS AND METHODS: Sixty-five school children were selected (aged 6-10 years), with four non-carious permanent first molar in different ES (OP (operculum present), ME (marginal edge), CE (completely erupted)). Split-mouth and single-blind study design was used...
June 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27335181/-the-failures-of-medicine
#8
EDITORIAL
Alberto Lifshitz
No abstract text is available yet for this article.
May 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/26831364/-can-t-you-initiate-me-here-challenges-to-timely-initiation-on-antiretroviral-therapy-among-methadone-clients-in-dar-es-salaam-tanzania
#9
Haneefa T Saleem, Dorothy Mushi, Saria Hassan, R Douglas Bruce, Alexis Cooke, Jessie Mbwambo, Barrot H Lambdin
BACKGROUND: Despite dramatic improvement in antiretroviral therapy (ART) access globally, people living with HIV who inject drugs continue to face barriers that limit their access to treatment. This paper explores barriers and facilitators to ART initiation among clients attending a methadone clinic in Dar es Salaam, Tanzania. METHODS: We interviewed 12 providers and 20 clients living with HIV at the Muhimbili National Hospital methadone clinic between January and February 2015...
April 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/26641188/chemical-composition-fermentation-characteristics-digestibility-and-degradability-of-silages-from-two-amaranth-varieties-kharkovskiy-and-sem-corn-and-an-amaranth-corn-combination
#10
N Karimi Rahjerdi, Y Rouzbehan, H Fazaeli, J Rezaei
Amaranth ( sp.) is a C plant adapted to poor soils and regions with limited rainfall and high temperatures. The plant is characterized by a yield of up to 85 t/ha, CP concentration of up to 28.5% of DM, and DM digestibility of 59 to 79%, which may vary depending on the species and variety. The potential of this plant as a forage source for ruminants has not been completely considered. This study aimed at assessing the nutritive value of silages from corn (), 2 amaranth () varieties (var. Kharkovskiy and Sem), and an amaranth-corn combination by chemical composition, silage fermentation characteristics, in vivo digestibility, and in situ DM degradability...
December 2015: Journal of Animal Science
https://www.readbyqxmd.com/read/26119455/signaling-control-of-differentiation-of-embryonic-stem-cells-toward-mesendoderm
#11
REVIEW
Lu Wang, Ye-Guang Chen
Mesendoderm (ME) refers to the primitive streak in mammalian embryos, which has the ability to further differentiate into mesoderm and endoderm. A better understanding on the regulatory networks of ME differentiation of embryonic stem (ES) cells would provide important insights on early embryo patterning and a possible guidance for ES applications in regenerative medicine. Studies on developmental biology and embryology have offered a great deal of knowledge about key signaling pathways involved in primitive streak formation...
April 10, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/25915816/-work-is-good-for-me-views-of-mental-health-service-users-seeking-work-during-the-uk-recession-a-qualitative-analysis
#12
Naomi Boycott, Athfah Akhtar, Justine Schneider
BACKGROUND: Individual placement and support (IPS) is an effective form of supported employment for people with severe mental illness. Little is known about service users' experiences of these programmes during economic recession. AIMS: Obtain service users' views of an IPS programme implemented in the UK during recession. METHOD: Thirty-one service users enrolled in an IPS programme were interviewed using a semi-structured protocol. The questions covered several areas of their experience, including problems faced in seeking work, perceived barriers in returning to work and what they found helpful in employment support...
April 2015: Journal of Mental Health
https://www.readbyqxmd.com/read/25453022/cannot-intubate-cannot-ventilate-in-a-neonate-due-to-giant-sublingual-cyst-a-simple-approach-to-airway-management
#13
Es Isamade, Ct Soo, Me Efu
Congenital sublingual/lingual cysts are rare, and may present with feeding difficulty; and rarely with respiratory distress in the neonate. A seven days old male neonate weighing 2.6kg was referred to a teaching hospital in Nigeria with a swelling in the oral cavity noticed at birth; associated with symptoms of inability to breastfeed, close the mouth and partial airway obstruction. Complete airway obstruction occurred, with cannot intubate- cannot ventilate situation during inhalational anaesthesia for surgical treatment, which was successfully managed...
April 2013: Journal of the West African College of Surgeons
https://www.readbyqxmd.com/read/25211486/synthesis-and-characterization-of-%C3%AE-triketimine-cobalt-complexes-and-their-behaviour-in-the-polymerization-of-1-3-butadiene
#14
Mohammed N Alnajrani, Francis S Mair
Three β-triketimine ligands, (L(1): [CH{CMeN(2,4,6-Me3-C6H2)}2C(CMe3N(2-MeO-C6H4)], L(2): [CH{CMeN(2,4-Me2-C6H3)}2C(CMe3N(2-MeO-C6H4)] and L(3): [CH{CMeN(2-Me-C6H4)}2C(CMe3N(2-MeO-C6H4)]), were synthesized and then characterized by (1)H and (13)C{(1)H} NMR spectroscopy, elemental analysis and electrospray (ES) MS. β-triketimine cobalt(ii) complexes were then prepared by the interaction of cobalt(ii) bromide with L(1-3) in the presence of NaBArF (BArF = [{3,5-(CF3)2-C6H3}4B](-) ). Five-coordinate dimeric bromide-bridged species [(LCoμ-Br)2][BArF]2 were obtained...
November 14, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24622725/a-series-of-ni-ii-flavonolate-complexes-as-structural-and-functional-es-enzyme-substrate-models-of-the-ni-ii-containing-quercetin-2-3-dioxygenase
#15
Ying-Ji Sun, Qian-Qian Huang, Jian-Jun Zhang
Ni(II)-flavonolate complexes [Ni(II)L(R)(fla)] (L(R)H: 2-{[bis(pyridin-2-ylmethyl)amino]methyl}-p/m-R-benzoic acid, R: p-OMe (1), p-Me (2), m-Br (4) and m-NO2 (5), fla: flavonolate) were synthesized and characterized with relevance to structural and functional models for the ES (enzyme-substrate) adduct of the Ni(II)-containing quercetin 2,3-dioxygenase (2,3-QD). Their structures, spectroscopic features, redox properties and the reactivity toward molecular oxygen have been investigated. The complexes show a similar distorted octahedral structure and higher enzyme-type dioxygenation reactivity than other reported metal-flavonolate complexes in the oxidative O-heterocyclic ring-opening of the bound substrate flavonolate at lower temperature owing to the introduced carboxylate group in the supporting model ligands...
May 7, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24601533/series-of-structural-and-functional-models-for-the-es-enzyme-substrate-complex-of-the-co-ii-containing-quercetin-2-3-dioxygenase
#16
Ying-Ji Sun, Qian-Qian Huang, Jian-Jun Zhang
A series of mononuclear Co(II)-flavonolate complexes [Co(II)L(R)(fla)] (L(R)H = 2-{[bis(pyridin-2-ylmethyl)amino]methyl}-p/m-R-benzoic acid; R = p-OMe (1), p-Me (2), m-Br (4), and m-NO2 (5); fla = flavonolate) were designed and synthesized as structural and functional models for the ES (enzyme-substrate) complexes to mimic the active site of the Co(II)-containing quercetin 2,3-dioxygenase (Co-2,3-QD). The metal center Co(II) ion in each complex shows a similar distorted octahedral geometry. The model complexes display high enzyme-type dioxygenation reactivity (oxidative O-heterocyclic ring opening of the coordinated substrate flavonolate) at low temperature, presumably due to the attached carboxylate group in the ligands...
March 17, 2014: Inorganic Chemistry
https://www.readbyqxmd.com/read/24512503/interaction-of-various-gas-molecules-with-paddle-wheel-type-open-metal-sites-of-porous-coordination-polymers-theoretical-investigation
#17
Yuh Hijikata, Shigeyoshi Sakaki
We theoretically evaluated binding energies (Eb's) between various gas molecules and the Cu center open metal site (Cu-OMS) of Cu paddle-wheel units, [Cu2(O2CR)4] (R = H, Me, or Ph) using density functional theory (DFT) and MP2-MP4. The optimized geometry of the model system [Cu2(O2CPh)4] agrees with the experimental structure. The Eb of CO with [Cu2(O2CH)4] is only slightly different between the open-shell singlet and triplet states. The calculated Eb decreases in the order MeNC > H2O > MeCN > C2H4 > C2H2 > CO > CO2 > N2 > CH4 > H2...
March 3, 2014: Inorganic Chemistry
https://www.readbyqxmd.com/read/24355806/neural-differentiation-of-mouse-embryonic-and-mesenchymal-stem-cells-in-a-simple-medium-containing-synthetic-serum-replacement
#18
Masoumeh Fakhr Taha, Arash Javeri, Omolbani Kheirkhah, Tayebeh Majidizadeh, Ali Reza Khalatbary
Neural differentiation of embryonic and adult stem cells has been reported previously. Several studies have used different proportions of serum or a cocktail of growth and differentiation factors for this purpose. In the present study, we examined neural differentiation of mouse embryonic stem (ES) cells in KoSR-containing media. We also investigated neural differentiation of mouse adipose tissue-derived stem cells (ADSCs) in a medium containing KoSR, a synthetic serum replacement, and compared it with neural differentiation in low-serum condition...
February 20, 2014: Journal of Biotechnology
https://www.readbyqxmd.com/read/23470161/ethanol-alters-the-balance-of-sox2-oct4-and-nanog-expression-in-distinct-subpopulations-during-differentiation-of-embryonic-stem-cells
#19
Joshua W Ogony, Evangelia Malahias, Rajanikanth Vadigepalli, Helen Anni
The transcription factors Sox2, Oct4, and Nanog regulate within a narrow dose-range embryonic stem (ES) cell pluripotency and cell lineage commitment. Excess of Oct4 relative to Sox2 guides cells to mesoendoderm (ME), while abundance of Sox2 promotes neuroectoderm (NE) formation. Literature does not address whether ethanol interferes with these regulatory interactions during neural development. We hypothesized that ethanol exposure of ES cells in early differentiation causes an imbalance of Oct4 and Sox2 that diverts cells away from NE to ME lineage, consistent with the teratogenesis effects caused by prenatal alcohol exposure...
August 1, 2013: Stem Cells and Development
https://www.readbyqxmd.com/read/22754085/experiencias-sobre-el-impacto-del-programa-de-formaci%C3%A3-n-en-%C3%A3-tica-de-la-investigaci%C3%A3-n-biom%C3%A3-dica-y-psicosocial-en-el-%C3%A3-mbito-de-la-salud-mental-y-la-investigaci%C3%A3-n-conductual
#20
Liliana Mondragón Barrios
El propósito de este trabajo es presentar el impacto y la integración que los conocimientos adquiridos en el Programa Internacional de Formación en Ética de la Investigación Biomédica y Psicosocial de la Universidad de Chile han tenido en mi experiencia profesional, en el ámbito de la investigación psicosocial en un Instituto de Salud de México. Para este objetivo, expondré tres áreas en las cuales se ha podido evidenciar tal impacto: trabajo en los comités de ética, desarrollo de programas de académicos en bioética e investigación y publicación sobre ética y bioética...
2012: Acta Bioethica
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