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JOURNAL ARTICLE
D D Cruz Nieto, N E Muguruza Crispin, C M Caira Mamani, H J Castro Bartolomé, M A Inga Sotelo, M N M Alberto, A S Valderrama Romero, V C Vargas Godoy, J M More López, H E Chanducas Tantaleán, N E Menacho Javier, M A Lara Castillo, W Flores Casanova, E R Benavente Ramírez, L A Apolín Montes, F Diestra Salinas
The increase in prices of fertilizers, energy and other materials necessary for the industry triggered a global economic crisis. Reason that was investigated on the biological and chemical characteristics in relation to the yield of radish nourished with humus from plant residue. The objective was to determine the appropriate dose of humus to obtain greater yield and its relationship with the chemical and biological characteristics of the radish. It is based on applied methodology with an experimental approach; Therefore, the Completely Random Block Design model was used, which consisted of 3 blocks and 5 treatments that were T1 with 0, T2 with 4, T3 with 6, T4 with 8 and T5 with 10 t/ha of humus and They applied 15 days after sowing...
2024: Brazilian Journal of Biology
#2
JOURNAL ARTICLE
Ariadna Pazos, Carlos M Cruz, Juan M Cuerva, Ivan Rivilla, Fernando P Cossío, Zoraida Freixa
A pair of enantiopure [6]-azairidahelicenes incorporating chirality at the metal center and on the helicenic ligand were synthesized by dynamic kinetic resolution (dkr) of a configurationally labile [4]-helicenic ligand (4-(2-pyridyl)-benzo[g]phenanthrene, L1H) using bis-cyclometalated chiral-at-metal only iridium(III) precursors as chiral inductors. The origin of the observed dkr is attributed to the different conformation and stability of diastereomeric reaction intermediates formed during the cyclometalation process...
April 24, 2024: Angewandte Chemie
#3
JOURNAL ARTICLE
Takumi Sakamaki, Yan Zhang, Shota Fukuma, Carlos M Cruz, Abel Cárdenas Valdivia, Araceli G Campaña, Juan Casado, Rui Shang, Eiichi Nakamura
Persistent chiral organic open-shell systems have captured growing interest due to their potential applications in organic spintronic and optoelectronic devices. Nevertheless, the integration of configurationally stable chirality into an organic open-shell system continues to pose challenges in molecular design. The π-extended skeleton incorporated in spiro-conjugated carbocycles can provide robust chiroptical properties and a significant stabilization of the excited and ionic radical states. However, this approach has been relatively less explored in the design of persistent organic open-shell systems...
April 24, 2024: Journal of the American Chemical Society
#4
JOURNAL ARTICLE
Guilherme S Lira, Victor A Ota, Mariana Q S Melo, Anna C P Castiñeiras, Isabela C Leitão, Bianca O Silva, Diana Mariani, Cássia C A Gonçalves, Liane J Ribeiro, Marcia Halpern, Thalita F Abreu, Fabiana A Carneiro, Helena T Scheid, Leonardo A V Souza, Débora G M Rodrigues, Nádia V G Cruz, Andrea Cony, Silvia Carvalho, Loyze P O de Lima, Vincent L Viala, Lucio A Caldas, Wanderley de Souza, Luiza M Higa, Carolina M Voloch, Orlando C Ferreira, Clarissa R Damaso, Rafael M Galliez, Débora S Faffe, Amilcar Tanuri, Terezinha M P P Castiñeiras
Mpox is a zoonotic disease historically reported in Africa. Since 2003, limited outbreaks have occurred outside Africa. In 2022, the global spread of cases with sustained interhuman transmission and unusual disease features raised public health concerns. We explore the mpox outbreak in Rio de Janeiro (RJ) state, Brazil, in an observational study of mpox-suspected cases from June to December 2022. Data collection relied on a public healthcare notification form. Diagnosis was determined by MPXV-PCR. In 46 confirmed cases, anti-OPXV IgG was determined by ELISA, and seven MPXV genomes were sequenced...
May 2024: Journal of Medical Virology
#5
JOURNAL ARTICLE
Claire F Friedman, Beryl L Manning-Geist, Qin Zhou, Tara Soumerai, Aliya Holland, Arnaud Da Cruz Paula, Hunter Green, Melih Arda Ozsoy, Alexia Iasonos, Travis Hollmann, Mario M Leitao, Jennifer J Mueller, Vicky Makker, William P Tew, Roisin E O'Cearbhaill, Ying L Liu, Maria M Rubinstein, Tiffany Troso-Sandoval, Stuart M Lichtman, Alison Schram, Chrisann Kyi, Rachel N Grisham, Pamela Causa Andrieu, E John Wherry, Carol Aghajanian, Britta Weigelt, Martee L Hensley, Dmitriy Zamarin
Programmed death-1 (PD-1) inhibitors are approved for therapy of gynecologic cancers with DNA mismatch repair deficiency (dMMR), although predictors of response remain elusive. We conducted a single-arm phase 2 study of nivolumab in 35 patients with dMMR uterine or ovarian cancers. Co-primary endpoints included objective response rate (ORR) and progression-free survival at 24 weeks (PFS24). Secondary endpoints included overall survival (OS), disease control rate (DCR), duration of response (DOR) and safety...
April 23, 2024: Nature Medicine
#6
REVIEW
Paula Collazo-Castiñeira, Macarena Sánchez-Izquierdo, Lea Joanne Reiter, Silvia Bauer, Alfonso J Cruz-Jentoft, Josje D Schoufour, Peter J M Weijs, Doris Eglseer
BACKGROUND: Sarcopenic obesity significantly burdens health and autonomy. Strategies to intervene in or prevent sarcopenic obesity generally focus on losing body fat and building or maintaining muscle mass and function. For a lifestyle intervention, it is important to consider psychological aspects such as behavioral change techniques (BCTs) to elicit a long-lasting behavioral change. PURPOSE: The study was carried out to analyze BCTs used in exercise and nutritional interventions targeting community-dwelling adults around retirement age with sarcopenic obesity...
April 16, 2024: Archives of Gerontology and Geriatrics
#7
JOURNAL ARTICLE
Andrew Mihalache, Ryan S Huang, Miguel Cruz-Pimentel, Nikhil S Patil, Marko M Popovic, Bhadra U Pandya, Reut Shor, Austin Pereira, Rajeev H Muni
No abstract text is available yet for this article.
April 22, 2024: Eye
#8
JOURNAL ARTICLE
Tianyang Mao, Jooyoung Kim, Mario A Peña-Hernández, Gabrielee Valle, Miyu Moriyama, Sophia Luyten, Isabel M Ott, Maria Luisa Gomez-Calvo, Jeff R Gehlhausen, Emily Baker, Benjamin Israelow, Martin Slade, Lokesh Sharma, Wei Liu, Changwan Ryu, Asawari Korde, Chris J Lee, Valter Silva Monteiro, Carolina Lucas, Huiping Dong, Yi Yang, Smita Gopinath, Craig B Wilen, Noah Palm, Charles S Dela Cruz, Akiko Iwasaki
Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interventions that are accessible and effective are urgently needed, especially in countries that are disproportionately affected. Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#9
JOURNAL ARTICLE
Ernesto Pérez-Sánchez, Raúl Montiel-Cruz, Eréndira Romero-Domínguez, Griselda Pascacio-Bermúdez, Arturo Báez-Hernández, Guadalupe Díaz Del Castillo-Flores, Fabián Correa-Morales, Gonzalo Vázquez-Prokopec, Pablo Manrique-Saide, Azael Che-Mendoza, Gabriela Meneses-Ruiz, Irma López-Martínez, María Jesús Sánchez
Introduction. In 2021, the Secretaría de Salud de México and the Pan American Health Organization launched an initiative to interrupt intra-domiciliary vector transmission of Trypanosoma cruzi based on the prevalence of Chagas disease in children. The Mexican State of Veracruz was leading this initiative. Objective. To estimate the seroprevalence of T. cruzi infection among children under 15 years of age from rural areas of Veracruz, México. Materials and methods. We identified eight localities of high priority from the Municipality of Tempoal, Veracruz, for baseline serology...
March 31, 2024: Biomédica: Revista del Instituto Nacional de Salud
#10
JOURNAL ARTICLE
S Salazar-García, A Ibáñez-Salazar, E Lares-Villaseñor, Noemi Gaytan Pacheco, E Uresti-Rivera, D P Portales-Pérez, U De la Cruz-Mosso, J M Vargas-Morales
The high prevalence of obesity in Mexico starting from the early stages of life is concerning and represents a major public health problem. Genetic association studies have reported that single nucleotide variants (SNVs) in SIRT1 , an NAD+- dependent deacetylase that plays an important role in the regulation of metabolic cellular functions, are associated with multiple metabolic disorders and the risk of obesity. In the present study, we analyzed the effect that the SNVs rs1467568 and rs7895833 of the SIRT1 gene may have on cardiometabolic risk factors in a young adult population from Mexico...
2024: Frontiers in Genetics
#11
REVIEW
Laura M Muñoz-Echeverri, Santiago Benavides-López, Otto Geiger, Mauricio A Trujillo-Roldán, Norma A Valdez-Cruz
Bacterial extracellular vesicles (BEVs) are non-replicative nanostructures released by Gram-negative and Gram-positive bacteria as a survival mechanism and inter- and intraspecific communication mechanism. Due to BEVs physical, biochemical, and biofunctional characteristics, there is interest in producing and using them in developing new therapeutics, vaccines, or delivery systems. However, BEV release is typically low, limiting their application. Here, we provide a biotechnological perspective to enhance BEV production, highlighting current strategies...
April 20, 2024: World Journal of Microbiology & Biotechnology
#12
JOURNAL ARTICLE
Tina L Cheng, Alyssa B Bennett, Teague M O'Mara, Giorgia G Auteri, F Frick Winifred, Santa Cruz
Emerging mycoses are an increasing concern in wildlife and human health. Given the historical rarity of fungal pathogens in warm-bodied vertebrates, there is a need to better understand how to manage mycoses and facilitate recovery in affected host populations. We explore challenges to host survival and mechanisms of host recovery in three bat species (Myotis lucifugus, Perimyotis subflavus, and M. septentrionalis) threatened with extinction by the mycosis, White-nose Syndrome (WNS) as it continues to spread across North America...
April 19, 2024: Integrative and Comparative Biology
#13
JOURNAL ARTICLE
Letícia P Foli, Maria C Hespanhol, Kaíque A M L Cruz, Celio Pasquini
The advent of miniaturized NIR instruments, also known as compact, portable, or handheld, is revolutionizing how technology can be employed in forensics. In-field analysis becomes feasible and affordable with these new instruments, and a series of methods has been developed to provide the police and official agents with objective, easy-to-use, tailored, and accurate qualitative and quantitative forensic results. This work discusses the main aspects and presents a comprehensive and critical review of compact NIR spectrophotometers associated with analytical protocols to produce information on forensic matters...
April 15, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
#14
JOURNAL ARTICLE
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, Lucía Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Džubur Kulenović, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Slavina B Goleva, Scott D Gordon, Aferdita Goçi, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian M J Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljević, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A Martínez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Alex O Rothbaum, Barbara O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Miranda Van Hooff, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Christiane Wolf, Erika J Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Keith A Young, Ross McD Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Terri deRoon-Cassini, Sanne J H van Rooij, Leigh L van den Heuvel, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new)...
April 18, 2024: Nature Genetics
#15
JOURNAL ARTICLE
Global Assessment of Palliative Care Need: Serious Health-Related Suffering Measurement Methodology.
Xiaoxiao J Kwete, Afsan Bhadelia, Héctor Arreola-Ornelas, Oscar Mendez, William E Rosa, Stephen Connor, Julia Downing, Dean Jamison, David Watkins, Renzo Calderon, Jim Cleary, Joe Friedman, Liliana De Lima, Christian Ntizimira, Tania Pastrana, Pedro E Pérez-Cruz, Dingle Spence, M R Rajagopal, Valentina Vargas Enciso, Eric L Krakauer, Lukas Radbruch, Felicia Marie Knaul
Inequities and gaps in palliative care access are a serious impediment to health systems especially low- and middle-income countries and the accurate measurement of need across health conditions is a critical step to understanding and addressing the issue. Serious Health-related Suffering (SHS) is a novel methodology to measure the palliative care need and was originally developed by The Lancet Commission on Global Access to Palliative Care and Pain Relief. In 2015, the first iteration - SHS 1.0 - was estimated at over 61 million people worldwide experiencing at least 6 billion days of SHS annually as a result of life-limiting and life-threatening conditions...
April 16, 2024: Journal of Pain and Symptom Management
#16
JOURNAL ARTICLE
Katharina Eichler, Stefanie Hampel, Adrián Alejandro-García, Steven A Calle-Schuler, Alexis Santana-Cruz, Lucia Kmecova, Jonathan M Blagburn, Eric D Hoopfer, Andrew M Seeds
Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that Drosophila perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al...
April 18, 2024: ELife
#17
JOURNAL ARTICLE
Sevde Dogruer Erkok, Emily Hernandez, Jordi Cruz, Alexander M Mebel, Bruce McCord
Fentanyl and fentanyl analogs are the main cause of recent overdose deaths in the United States. The presence of fentanyl analogs in illicit drugs makes it difficult to estimate their potencies. This makes the detection and differentiation of fentanyl analogs critically significant. Surface-enhanced Raman spectroscopy (SERS) can differentiate structurally similar fentanyl analogs by yielding spectroscopic fingerprints for the detected molecules. In previous years, five fentanyl analogs, carfentanil, furanyl fentanyl, acetyl fentanyl, 4-fluoroisobutyryl fentanyl (4-FIBF), and cyclopropyl fentanyl (CPrF), gained popularity and were found in 76...
April 18, 2024: Applied Spectroscopy
#18
JOURNAL ARTICLE
Javier C Angulo, Alessandro Giammò, Fabian Queissert, Sandra Schönburg, Carmen González-Enguita, Andreas Gonsior, Antonio Romero, Francisco E Martins, Tiago Antunes-Lopes, Raquel González, Juliusz Szczesniewski, Carlos Téllez, Francisco Cruz, Keith F Rourke
OBJECTIVES: This study aimed to compare the effectiveness and safety of the adjustable trans-obturator male system (ATOMS®) to treat post-prostatectomy incontinence (PPI) in radiated patients compared with non-radiated patients, using propensity score-matching analysis to enhance the validity of the comparison. PATIENTS AND METHODS: Consecutive men with PPI treated with silicone-covered scrotal port ATOMS (A.M.I., Feldkirch, Austria) in nine different institutions between 2016 and 2022 were included...
April 2024: BJUI compass
#19
JOURNAL ARTICLE
Erika Bastos Lima Freire, Catarina Brasil d'Alva, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, Leonardo Barreira Portella, Renan Galvão Ozório, Clarisse Mourão Melo Ponte, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro Junior
INTRODUCTION: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease caused by mutations in genes responsible for the formation and development of adipocytes. Bone abnormalities are described. However, there is a scarcity of data. OBJECTIVE: To describe bone characteristics in a large CGL1 and 2 case series. METHODS: Cross-sectional study that assessed bone radiological features of CGL patients of a reference hospital in Fortaleza (CE), Brazil...
2024: Frontiers in Endocrinology
#20
Sushmita Gordhandas, Arnaud Da Cruz Paula, Elizabeth C Kertowidjojo, Fresia Pareja, Kimberly Dessources, Edaise M da Silva, Fatemeh Derakhshan, Jennifer J Mueller, Nadeem R Abu-Rustum, M Herman Chui, Britta Weigelt
•Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site.•The two endometrioid ECs studied acquired additional mutations during the distant metastatic process.•Subclonal CTNNB1 hotspot mutations in the two primary ECs studied became clonal in the distant metastases.
June 2024: Gynecologic Oncology Reports
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