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https://www.readbyqxmd.com/read/27910712/development-of-a-nanogel-formulation-for-transdermal-delivery-of-tenoxicam-a-pharmacokinetic-pharmacodynamic-modeling-approach-for-quantitative-prediction-of-skin-absorption
#1
Mohammed H Elkomy, Shahira F El Menshawe, Hussein M Eid, Ahmed M A Ali
This study investigates potentials of solid lipid nanoparticles (SLN) based gel for transdermal delivery of tenoxicam (TNX) and describes a pharmacokinetics-pharmacodynamics (PK-PD) modeling approach for predicting concentration-time profile in skin. A 2(3) factorial design was adopted to study the effect of formulation factors on SLN properties and determine the optimal formulation. SLN-gel tolerability was investigated using rabbit skin irritation test. Its anti-inflammatory activity was assessed by carrageenan induced rat paw edema test...
December 2, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27871565/postoperative-analgesic-efficacy-of-fascia-iliaca-block-versus-periarticular-injection-for-total-knee-arthroplasty
#2
Cagla Bali, Ozlem Ozmete, H Evren Eker, Murat A Hersekli, Anis Aribogan
STUDY OBJECTIVE: This study evaluated the postoperative analgesic efficacies of fascia iliaca block and periarticular drug injection techniques after TKA (total knee arthroplasty) surgeries. DESIGN: Prospective, randomized clinical trial. SETTING: University Teaching and Research Center. PATIENTS: Seventy-one American Society of Anesthesiologists (ASA) I-III patients between 48 and 70 years of age who underwent total knee arthroplasty were randomized...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27830044/acute-pain-management-in-symptomatic-cholelithiasis
#3
Tahir Masudi, Helen Capitelli-McMahon, Suhail Anwar
AIM: To review the evidence for the use of different non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of biliary colic. METHODS: The strategies employed included an extensive literature review for articles and studies related to biliary colic from electronic databases including PubMed, Science Direct, Wiley Inter Science, Medline and Cochrane from last 15 years. Keywords: "Biliary colic", "management of biliary colic", "non-steroidal anti-inflammatory drugs", "cholelithiasis" and "biliary colic management"...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27813032/-comparison-of-triptans-nsaid-and-combination-in-migraine-attack-treatment
#4
Taşkın Duman, Hava Özlem Dede, Gülşah Şeydaoğlu
OBJECTIVES: Headache during migraine attack may recur during a single attack. The present study evaluated efficacy of both individual and combined use of agents from nonsteroidal anti-inflammatory drug (NSAID) and triptan groups widely used in treatment of migraine attacks. METHODS: A total of 201 attacks in 67 migraine patients were evaluated. Patients were divided into 3 study groups: those receiving rizatriptan 10mg, tenoxicam 20 mg, and rizatriptan + tenoxicam (combination)...
July 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/27311846/comparison-of-the-effects-of-daily-single-dose-use-of-flurbiprofen-diclofenac-sodium-and-tenoxicam-on-postoperative-pain-swelling-and-trismus-a-randomized-double-blind-study
#5
Volkan Kaplan, Cennet Neslihan Eroğlu
PURPOSE: The aim of the present study was to compare the effects of daily single-dose use of flurbiprofen, diclofenac sodium, and tenoxicam on pain, swelling, and trismus that occur after surgical extraction of impacted wisdom teeth using local anesthesia. MATERIALS AND METHODS: The present study included 3 groups with 30 patients in each group. Those volunteering to participate in this double-blind randomized study (n = 90) were selected from a patient population with an indication for extraction of impacted wisdom teeth...
October 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27290960/comparison-of-postoperative-analgesic-efficacy-of-intraoperative-single-dose-intravenous-administration-of-dexketoprofen-trometamol-and-diclofenac-sodium-in-laparoscopic-cholecystectomy
#6
Ali Anıl, Fatma Nur Kaya, Belgin Yavaşcaoğlu, Esra Mercanoğlu Efe, Gürkan Türker, Abdurrahman Demirci
STUDY OBJECTIVE: The aim of this study is to compare the effects of intravenous single-dose dexketoprofen trometamol and diclofenac sodium 30 minutes before the end of the surgery on relief of postoperative pain in patients undergoing laparoscopic cholecystectomy. DESIGN: A randomized fashion. SETTING AND PATIENTS: Sixty (American Society of Anesthesiologist class I-II) patients undergoing laparoscopic cholecystectomy were divided into 2 groups INTERVENTION: Patients in group DT received 50 mg dexketoprofen trometamol, whereas patients in group DS received 75 mg diclofenac sodium, intravenously 30 minutes before the end of surgery...
August 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27269807/effectiveness-of-corticosteroid-injections-in-the-treatment-of-plantar-fasciitis
#7
Shanna L Karls, Kelli R Snyder, Peter J Neibert
CLINICAL SCENARIO: For active individuals, plantar fasciitis (PF) is one of the most clinically diagnosed causes of heel pain. When conservative treatment fails, one of the next most commonly used treatments includes corticosteroid injections. Although PF has been identified as a degenerative condition, rather than inflammatory, corticosteroid injection is still commonly prescribed. However, the literature has not been examined to determine the effect of corticosteroid injection on PF...
May 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/26524404/inhibition-of-islet-amyloid-polypeptide-aggregation-and-associated-cytotoxicity-by-nonsteroidal-anti-inflammatory-drugs
#8
Jessica S Fortin, Marie-Odile Benoit-Biancamano
Nonsteroidal anti-inflammatory drugs (NSAIDs) constitute an important pharmacotherapeutic class that, over the past decade, have expanded in application to a panoply of medical conditions. They have been tested for neurodegenerative diseases such as Alzheimer's to reduce inflammation and also in the attempt to abrogate amyloid deposition. However, the use of NSAIDs as aggregation inhibitors has not been extensively studied in pancreatic amyloid deposition. Pancreatic amyloidosis involves the misfolding of islet amyloid polypeptide (IAPP) and contributes to the progression of type-2 diabetes in humans and felines...
January 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26475417/nefopam-analgesia-and-its-role-in-multimodal-analgesia-a-review-of-preclinical-and-clinical-studies
#9
REVIEW
Philippe Girard, Marcel Chauvin, Marc Verleye
Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug used to prevent postoperative pain, primarily in the context of multimodal analgesia. This paper reviews preclinical and clinical studies in which nefopam has been combined with opioids, non-steroidal anti-inflammatory compounds, and paracetamol. This report focuses on the literature during the last decade and discusses the translational efforts between animal and clinical studies in the context of multimodal or balanced analgesia. In preclinical rodent models of acute and inflammatory pain, nefopam combinations including opioids revealed a synergistic interaction or enhanced morphine analgesia in six out of seven studies...
January 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/26453988/scavenging-of-photogenerated-ros-by-oxicams-possible-biological-and-environmental-implications
#10
Gabriela V Ferrari, José Natera, M Paulina Montaña, Vanesa Muñoz, Eduardo L Gutiérrez, Walter Massad, Sandra Miskoski, Norman A García
The profusely employed drugs Piroxicam (Piro), Tenoxicam (Teno) and Meloxicam (Melo) belonging to the non-steroidal antiinflammatory drug (NSAID) family of the Oxicams (Oxis) were studied in the frame of two specific conditions: (a) their ROS scavenging ability, in relation to a possible biological antioxidant action and (b) their photodegradability under environmental conditions, in the context of Oxi-contaminated waters. Singlet molecular oxygen (O2((1)Δg)) and superoxide radical anion (O2(-)) were photogenerated through Riboflavin (Rf, vitamin B2)-photosensitization in aqueous and aqueous-methanolic solutions in the presence of Oxi concentrations in the range 50-500 μM...
December 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26414123/single-dose-oral-analgesics-for-acute-postoperative-pain-in-adults-an-overview-of-cochrane-reviews
#11
REVIEW
R Andrew Moore, Sheena Derry, Dominic Aldington, Philip J Wiffen
BACKGROUND: This is an updated version of the original Cochrane overview published in Issue 9, 2011. That overview considered both efficacy and adverse events, but adverse events are now dealt with in a separate overview.Thirty-nine Cochrane reviews of randomised trials have examined the analgesic efficacy of individual drug interventions in acute postoperative pain. This overview brings together the results of those individual reviews and assesses the reliability of available data. OBJECTIVES: To summarise the efficacy of pharmaceutical interventions for acute pain in adults with at least moderate pain following surgery who have been given a single dose of oral analgesic...
September 28, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26374114/comparison-of-intra-articular-bupivacaine-morphine-with-bupivacaine-tenoxicam-combinations-on-post-operative-analgesia-in-patients-with-arthroscopic-meniscectomy-a-prospective-randomised-study
#12
RANDOMIZED CONTROLLED TRIAL
Selim Sanel, Osman Arpaz, Koray Unay, Ismail Turkmen, Selcuk Simsek, Ender Ugutmen
AIM: There are many alternatives for post-operative pain relief in patients who have had general anaesthesia. The aim of this study was to evaluate the efficacy of intra-articular bupivacaine + morphine and bupivacaine + tenoxicam applications in post-operative pain control in patients undergoing knee arthroscopy with general anaesthesia. METHOD: This was a prospective study. Standard anaesthesia procedures were applied to each patient, and the 240 patients chosen at random were then divided into two groups...
March 2016: International Orthopaedics
https://www.readbyqxmd.com/read/26363688/-comparison-of-the-effectivity-of-oral-and-intra-articular-administration-of-tenoxicam-in-patients-with-knee-osteoarthritis
#13
Mesut Erbas, Tuncer Simsek, Hasan Ali Kiraz, Hasan Sahin, Huseyin Toman
BACKGROUND AND OBJECTIVES: Tenoxicam is widely used in osteoarthritis treatment and we aimed to compare the effectivity of oral and intra-articular administration of tenoxicam in osteoarthritis treatment. METHODS: This study was performed between 2011 and 2012 by retrospectively analyzing and comparing the findings of 60 patients who were clinically and radiologically diagnosed with knee degenerative osteoarthritis in Bünyan state hospital pain policlinic. 60 patients included in the study were divided into two groups...
September 2015: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/26344122/the-effect-of-methylprednisolone-and-tenoxicam-on-the-protection-of-damage-of-the-nerve-physiomorphology-caused-by-prolene-mesh
#14
Zeki Ozsoy, Huseyin Ayhan Kayaoglu, Namık Ozkan, Seyma Ozsoy, Faik Yaylak, Erdinc Yenidogan
INTRODUCTION: Aim was to investigate the effect of methylprednisolone and tenoxicam on the protection of damage of the nerve physiomorphology caused by prolene mesh used in hernia repair. METHODS: Fifty male Wistar-albino rats weighing 250-350 gr, were randomly divided into 5 groups. Sciatic nerve was dissected in all rats after performing EMG on basal neural transport. In group 1, only sciatic nerve manipulation was performed. Other groups received a monofilament polypropylene cuff around the sciatic nerve...
October 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/26323729/comparison-of-the-effectivity-of-oral-and-intra-articular-administration-of-tenoxicam-in-patients-with-knee-osteoarthritis
#15
Mesut Erbas, Tuncer Simsek, Hasan Ali Kiraz, Hasan Sahin, Huseyin Toman
BACKGROUND AND OBJECTIVES: Tenoxicam is widely used in osteoarthritis treatment and we aimed to compare the effectivity of oral and intra-articular administration of tenoxicam in osteoarthritis treatment. METHODS: This study was performed between 2011 and 2012 by retrospectively analyzing and comparing the findings of 60 patients who were clinically and radiologically diagnosed with knee degenerative osteoarthritis in Bünyan state hospital pain policlinic. 60 patients included in the study were divided into two groups...
September 2015: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26312474/comparison-of-the-effects-of-chronic-intra-articular-administration-of-tenoxicam-diclofenac-and-methylprednisolone-in-healthy-rats
#16
Mehmet Müfit Orak, Dursun Ak, Ahmet Midi, Berna Laçin, Sevim Purisa, Güven Bulut
OBJECTIVE: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint...
2015: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/26285672/microemulsion-based-topical-hydrogels-of-tenoxicam-for-treatment-of-arthritis
#17
Shishu Goindi, Manleen Narula, Atin Kalra
Tenoxicam (TNX) is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, backache and pain. However, prolonged oral use of this drug is associated with gastrointestinal adverse events like peptic ulceration, thus necessitating its development as topical formulation that could obviate the adverse effects and improve patient compliance. The present study was aimed at development of microemulsion-based formulations of TNX for topical delivery at the affected site...
June 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/26248636/comparative-efficacy-of-non-steroidal-anti-inflammatory-drugs-in-ankylosing-spondylitis-a-bayesian-network-meta-analysis-of-clinical-trials
#18
Runsheng Wang, Abhijit Dasgupta, Michael M Ward
OBJECTIVE: To compare the efficacy of 20 non-steroidal anti-inflammatory drugs (NSAIDs) in the short-term treatment of ankylosing spondylitis (AS). METHODS: We performed a systematic literature review of randomised controlled trials of NSAIDs in patients with active AS. We included trials that reported efficacy at 2-12 weeks. Efficacy outcomes were the change in pain score and change in the duration of morning stiffness. We also examined the number of adverse events...
June 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26161321/the-analgesic-effects-of-morphine-and-tramadol-added-to-intra-articular-levobupivacaine-tenoxicam-combination-for-arthroscopic-knee-surgery-on-postoperative-pain-a-randomized-clinical-trial
#19
Ebru Gelici Oral, Ayse Hanci, Gulcihan Ulufer Sivrikaya, Hale Dobrucali, Leyla Turkoglu Kilinc
BACKGROUND: Arthroscopic knee surgery is commonly performed as an outpatient procedure and is often associated with postoperative pain. OBJECTIVES: We aimed to compare the effects of intra-articular levobupivacaine-tenoxicam-tramadol and levobupivacaine-tenoxicam-morphine combinations on postoperative pain in patients undergoing elective arthroscopic knee surgery. MATERIALS AND METHODS: A total of 90 ASA I-II patients undergoing elective arthroscopic meniscectomy under general anesthesia were enrolled...
June 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26147344/differential-effect-of-oxicam-non-steroidal-anti-inflammatory-drugs-on-membranes-and-their-consequence-on-membrane-fusion
#20
Anupa Majumdar, Debjyoti Kundu, Munna Sarkar
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used analgesics and antipyretics, which form an interesting drug group because of their new and alternate functions. The ability of the NSAIDs belonging to the oxicam chemical group to induce membrane fusion at low physiologically relevant concentrations is a new function that has drawn considerable attention. Membrane fusion is dependent on the interplay of physicochemical properties of both drugs and membranes. Here, we have elucidated the effects of different oxicam drugs, Meloxicam, Piroxicam, Tenoxicam, Lornoxicam, and Isoxicam, on an identical membrane-mimetic system...
July 30, 2015: Journal of Physical Chemistry. B
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