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lornoxicam

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https://www.readbyqxmd.com/read/28639085/nonsteroid-anti-inflammatory-therapy-suppresses-the-development-of-proliferative-vitreoretinopathy-more-effectively-than-a-steroid-one
#1
Marina V Tikhonovich, Aleksei K Erdiakov, Svetlana A Gavrilova
PURPOSE: This study proves the possibility of targeted use of the nonsteroidal anti-inflammatory drug lornoxicam to prevent the development of proliferative vitreoretinopathy (PVR). Triamcinolone acetonide (TA) was selected as a reference substance. METHODS: Wistar rats (N = 400) were used. PVR was modeled by intravitreal injection of dispase or concanavalin A. Lornoxicam or TA intravitreal administration was performed 20 min later. On the second and the third day, drugs were administrated systemic...
June 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28449627/lornoxicam-use-to-reduce-the-pain-associated-with-propofol-injection
#2
Nihal Başak, Yakup Aksoy, Ayhan Kaydu, Ömer Fatih Şahin
AIM: To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection. MATERIAL AND METHOD: Approval for this study was granted by the ethics committee of our hospital. Using a computer randomisation software, 120 patients undergoing elective surgery were assigned to four equal groups. In Group I (control group), immediately before anaesthesia induction, 10 ml of isotonic 0.9% NaCl solution (placebo) was administered intravenously (IV)...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28338301/analgesia-for-patients-undergoing-shockwave-lithotripsy-for-urinary-stones-a-systematic-review-and-meta-analysis
#3
Omar M Aboumarzouk, Rami Hasan, Ali Tasleem, Martin Mariappan, Rachael Hutton, John Fitzpatrick, Laura Beatty, Gareth E Jones, Tarik Amer
BACKGROUND: Shock wave lithotripsy (SWL) is the first line treatment modality for a significant proportion of patients with upper urinary tracts stones. Simple analgesics, opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are all suitable agents but the relative efficacy and tolerability of these agents is uncertain. OBJECTIVES: To determine the efficacy of the different types of analgesics used for the control of pain during SWL for urinary stones. MATERIALS AND METHODS: We searched the Cochrane Renal Group's Specialised Register, MEDLINE, EMBASE and also hand-searched reference lists of relevant articles (Figure-1)...
May 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28283842/a-pharmaceutical-study-on-lornoxicam-fast-disintegrating-tablets-formulation-and-in-vitro-and-in-vivo-evaluation
#4
Mohamed Yousif Moutasim, Aliaa Nabil ElMeshad, Mohamed Ahmed El-Nabarawi
Lornoxicam is an anti-inflammatory drug used to relieve rheumatoid arthritis pain, but the low water solubility and bitter taste of the drug present challenges for formulation as fast disintegrating tablets (FDTs). Complexation of the drug with β-cyclodextrin was initially carried out to increase the drug solubility and to mask its bitter taste. Tablets were prepared by direct compression of drug complex (DC), F-Melt, mannitol, crospovidone, and sodium starch glycolate (SSG). FDTs were characterized in terms of disintegration time (DT) and dissolution...
March 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#5
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28235624/design-of-novel-injectable-in-situ-forming-scaffolds-for-non-surgical-treatment-of-periapical-lesions-in-vitro-and-in-vivo-evaluation
#6
Rehab N Shamma, Nermeen A Elkasabgy, Azza A Mahmoud, Shaimaa I Gawdat, Mohamed M Kataia, Mohamed A Abdel Hamid
Periapical lesions are considered one of the common pathological conditions affecting alveolar bone. The primary focus of this study was to investigate the effectiveness of formulating an injectable in-situ forming scaffold-loaded with risedronate (bone resorption inhibitor) and with lornoxicam (anti-inflammatory drug) for the non-surgical treatment of periapical lesions. The scaffolds were prepared using solvent-induced phase inversion technique. Two insoluble copolymers were investigated namely; PLGA (ester-terminal) and PLGA-A (acid-terminal), additionally, SAIB was added as a high viscosity water-insoluble carrier...
April 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28176487/lornoxicam-immediate-release-tablets-formulation-and-bioequivalence-study-in-healthy-mediterranean-volunteers-using-a-validated-lc-ms-ms-method
#7
Abdel Naser Zaid, Ayman Mousa, Nidal Jaradat, Rana Bustami
This study aimed to demonstrate interchangeability between 2 lornoxicam tablet formulations under fasting conditions among Mediterranean Arabs by using a newly validated high-pressure liquid chromatography-tandem mass spectrometry method. A single-oral solid dosage form (8 mg/tablet), randomized, open-label, 2-way crossover study was conducted on 30 healthy male volunteers. Blood samples were collected prior to dosing and over a 24-hour period, and the washout period was 9 days. Statistical comparison of the main pharmacokinetic parameters showed no significant difference between generic and branded products...
February 8, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28111731/comparison-of-lornoxicam-and-low-dose-tramadol-for-management-of-post-thyroidectomy-pain
#8
Ali Yücel, Alper Yazıcı, Togay Müderris, Fatih Gül
OBJECTIVES: The present study sought to compare the analgesic efficacy and adverse effects of intravenous (IV) lornoxicam and tramadol to investigate if lornoxicam is a reasonable alternative to a weak opioid for post-thyroidectomy pain. METHODS: Fifty patients of American Society of Anesthesiologists class I or II, 18 to 65 years of age, and who underwent thyroidectomy were assigned to 2 groups in a randomized manner. Group L received 8 mg of lornoxicam IV and Group T received 1 mg/kg of tramadol IV at conclusion of the operation...
October 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28057390/pre-emptive-analgesic-effect-of-lornoxicam-in-mandibular-third-molar-surgery-a-prospective-randomized-double-blind-clinical-trial
#9
I M Mojsa, J Stypulkowska, P Novak, K Lipczynski, K Szczeklik, M Zaleska
The aim of this study was to establish whether the pre-emptive use of lornoxicam (16mg) in third molar surgery ensures successful postoperative analgesia and reduces rescue analgesic intake when compared to postoperative application, and in comparison with placebo. Ninety patients were split randomly into three groups: group A received lornoxicam 60min before surgery and placebo 60min after surgery; group B received placebo 60min before surgery and lornoxicam 60min after surgery; group C received placebo 60min before surgery and placebo 60min after surgery...
January 2, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27746536/comparison-of-the-efficacy-of-lornoxicam-and-fentanyl-in-attenuating-the-hemodynamic-response-to-laryngoscopy-and-intubation
#10
U N Swarnamba, K Veena, Safiya I Shaikh
BACKGROUND AND OBJECTIVES: Laryngoscopy and intubation elicits huge spectrum of stress response which is hazardous in high-risk patients. Many drugs and techniques have been used to attenuate the stress response. Lornoxicam 16 mg is a potent nonsteroidal anti-inflammatory drug agent with analgesic potency equivalent to morphine 10 mg, fentanyl 100 μg and tramadol 100 mg. Lornoxicam has been found to attenuate stress response in some studies. We compared the lornoxicam with fentanyl in attenuating stress response...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27671477/formulation-and-evaluation-of-injectable-in-situ-forming-microparticles-for-sustained-delivery-of-lornoxicam
#11
Soad Ali Yehia, Sally Adel Abdel-Halim, Mary Yosry Aziz
The objective of this study is to formulate biodegradable in situ microparticles (ISM) containing lornoxicam for post-operative and arthritic pain management. ISM emulsions were prepared according to 2(5) full factorial experimental design to investigate the influence of formulation variables on the release profile of the drug. The independent variables studied are the polymer type, polymer inherent viscosity, polymer concentration, oil type and polymer:oil ratio. In vitro drug release, microscopical examination, particle size determination and syringeability measurement were selected as dependent variables...
October 21, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27554932/spectroscopic-studies-on-the-interaction-of-dna-with-the-copper-complexes-of-nsaids-lornoxicam-and-isoxicam
#12
Sathi Goswami, Suhita Ray, Munna Sarkar
Non Steroidal Anti-inflammatory Drugs (NSAIDs) form the most common class of anti-inflammatory and analgesic agents. They also show anticancer properties for which they exert their effects by interacting at the protein but not at the genomic level. This is because most NSAIDs are anions at physiological pH, which prohibit their approach to the polyanionic DNA backbone. Complexing NSAIDs with bioactive metal like copper obliterates this disadvantage. Here, copper complexes of two oxicam NSAIDs, Lornoxicam (Lx) and Isoxicam (Isx) have been chosen to study their interaction with calf thymus (ct) DNA and have been synthesized as per reported protocols...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27536068/effects-of-lornoxicam-and-intravenous-ibuprofen-on-erythrocyte-deformability-and-hepatic-and-renal-blood-flow-in-rats
#13
Hande Arpacı, Faruk Metin Çomu, Ayşegül Küçük, Bahadır Kösem, Seyfi Kartal, Volkan Şıvgın, Hüseyin Cihad Turgut, Muhammed Enes Aydın, Derya Sebile Koç, Mustafa Arslan
BACKGROUND: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27523985/effects-of-nsaids-on-the-osteogenic-differentiation-of-human-adipose-tissue-derived-stromal-cells
#14
COMPARATIVE STUDY
Chrystalleni Hadjicharalambous, Vasileia Ismini Alexaki, Kalliopi Alpantaki, Maria Chatzinikolaidou
OBJECTIVES: Non-steroidal anti-inflammatory drugs (NSAIDs), used in the treatment of musculoskeletal pathologies, have been associated with impaired bone healing, possibly through inhibition of osteogenic differentiation. The adipose tissue (AT) is regarded as an attractive source of stromal cells for autologous cell transplantation in the bone. The effects of NSAIDs on human AT-derived stromal cells (hADSCs) are unknown. METHODS: We examined the effect of several NSAIDs including meloxicam, parecoxib, lornoxicam, diclofenac and paracetamol on the proliferation of hADSCs by means of the PrestoBlue(®) viability assay, and the osteogenic differentiation capacity of hADSCs by means of the alkaline phosphatase (ALP) activity, calcium deposition by alizarin red staining and osteogenic gene expression by semi-quantitative PCR...
November 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27494155/comparative-study-on-the-in-vitro-performance-of-blister-molded-and-conventional-lornoxicam-immediate-release-liquitablets-accelerated-stability-study-and-anti-inflammatory-and-ulcerogenic-effects
#15
COMPARATIVE STUDY
Doaa Ahmed El-Setouhy, Alaa Abdel-Rahman Gamiel, Alia Abd El-Latif Badawi, Afaf Sayed Osman, Dina Ahmed Labib
CONTEXT: Lornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID). It shows limited solubility in the gastric pH, delayed bioavailability and pharmacodynamic effects with aggravated gastric side effects (due to longer residence in the stomach wall). OBJECTIVE: To enhance dissolution of lornoxicam in the gastric fluid and expectedly absorption and pharmacological action, with less ulcerogenic effects. MATERIALS AND METHODS: Formulation of immediate release (IR) lornoxicam liquitablets containing both liquid and solid release modulators (wetting agent, solubilizers and microenvironmental pH modifiers)...
March 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27468823/lornoxicam-injection-is-inferior-to-betamethasone-in-the-treatment-of-subacromial-impingement-syndrome-a-prospective-randomized-study-of-functional-outcomes
#16
M Aksakal, C Ermutlu, G Özkaya, Y Özkan
BACKGROUND: Subacromial impingement syndrome (SIS) is one of the most frequent shoulder pathologies. Initial treatment is conservative. Subacromial injection of drugs achieves a high concentration at the pathologic site with less drug use and fewer systemic side effects. Glucocorticoids are most frequently injected. One concern with steroid use is the wide array of potential systemic and local complications. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also peripherally acting and can be used locally...
February 2017: Der Orthopäde
https://www.readbyqxmd.com/read/27460936/quality-by-design-empowered-development-and-optimisation-of-time-controlled-pulsatile-release-platform-formulation-employing-compression-coating-technology
#17
Riddhish Patadia, Chintan Vora, Karan Mittal, Rajashree C Mashru
The research was envisaged for development of time-controlled pulsatile release (PR) platform formulation to facilitate management of early morning chronological attacks. The development was started using prednisone as a model drug wherein core tablets were prepared using direct compression method and subsequently compression-coated with ethylcellulose (EC)-hydroxypropyl methylcellulose (HPMC) excipient blend. Initially, quality target product profile was established and risk assessment was performed using failure mode and effect analysis...
July 26, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27459481/-risk-factors-and-prevention-of-postoperative-pancreatitis-after-pancreatectomy
#18
RANDOMIZED CONTROLLED TRIAL
A G Kriger, E A Akhtanin, V M Zemskov, D S Gorin, A V Smirnov, S V Berelavichus, M N Kozlova, N S Shishkina, A V Glotov
AIM: to improve the results of pancreatic resections through decrease of postoperative pancreatitis incidence. MATERIAL AND METHODS: It was analyzed 207 patients who underwent pancreatic surgery for pancreatic tumor (n=137) or chronic pancreatitis (n=70). 22 risk factors of postoperative pancreatitis were analyzed in 112 patients retrospectively. In prospective study of 95 patients the efficacy of lornoxicam to prevent postoperative pancreatitis was assessed. 68 parameters of immune state were studied to estimate effect of lornoxicam...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27371394/lecithin-and-plga-based-self-assembled-nanocomposite-lecithmer-preparation-characterization-and-pharmacokinetic-pharmacodynamic-evaluation
#19
Seby Elsy Varghese, Mayur K Fariya, Gopal Singh Rajawat, Frank Steiniger, Alfred Fahr, Mangal S Nagarsenker
The present study investigates the drug delivery potential of polymer lipid hybrid nanocomposites (Lecithmer®) composed of poly(D,L-lactide-co-glycolide (PLGA) and soya lecithin. Core-shell structure of Lecithmer was evident from cryo-TEM images. Daunorubicin (DNR) and lornoxicam (LNX)-incorporated Lecithmer nanocomposites were evaluated for anticancer and anti-inflammatory activity. DNR- and LNX-loaded Lecithmer had mean particle size of ∼335 and ∼282.7 nm, respectively. Lecithmer formulated with different cationic lipids resulted in lower particle size (∼120 nm) and positive zeta potential...
August 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27336868/incompatibilities-of-lornoxicam-with-4-antiemetic-medications-in-polyolefin-bags-during-simulated-intravenous-administration
#20
RANDOMIZED CONTROLLED TRIAL
Bao-Xia Fang, Peng Li, Xiao-Ya Shi, Fu-Chao Chen, Lin-Hai Wang
The administration of drugs by patient-controlled analgesia (PCA) is routinely practiced for the management of postoperative pain. It is common for 2 or more drugs to be combined in PCA solutions. The combination of analgesics and antiemetic agents is frequently required. Unfortunately, the compatibility and stability of lornoxicam and antiemetic agents, such as droperidol, ondansetrone, granisetron, and tropisetron, has not been determined. The aim of this study was to evaluate the compatibility and stability of solutions containing lornoxicam with the 4 antiemetic agents in combination for PCA administration...
June 2016: Medicine (Baltimore)
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