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https://www.readbyqxmd.com/read/29243848/analgesic-efficacy-of-preoperative-dexketoprofen-trometamol-a-systematic-review-and-meta-analysis
#1
Vicente Esparza-Villalpando, Amaury Pozos-Guillén, David Masuoka-Ito, César Gaitán-Fonseca, Daniel Chavarría-Bolaños
Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017...
December 15, 2017: Drug Development Research
https://www.readbyqxmd.com/read/29219057/formulation-optimization-and-in-vitro-and-in-vivo-evaluation-of-lornoxicam-ethosomal-gels-with-penetration-enhancers
#2
Keke Li, Shanshan Gao, Baocheng Tian, Yanan Shi, Qingzhi Lv, Jingtian Han
BACKGROUND: Ethosomes, a novel type of percutaneous drug delivery carrier with a lipid bilayer structure, penetrate the skin barrier due to their deformability and malleability, and presence of ethanol that fluidizes lipids in the skin. In order to further enhance the delivery of drugs through the skin, penetration enhancers are widely used. OBJECTIVE: The objective of this work was to develop an optimized formulation of lornoxicam ethosomal gels, investigate skin permeability with the addition of penetration enhancers, and evaluate the in vivo pharmacodynamics of these formulations...
December 7, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29187701/association-between-concomitant-use-of-acyclovir-or-valacyclovir-with-nsaids-and-an-increased-risk-of-acute-kidney-injury-data-mining-of-fda-adverse-event-reporting-system
#3
Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li
NSAIDs are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury(AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration(FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012. The frequency of AKI events in patients while simultaneously taking either acyclovir or valacyclovir and an NSAID was compared using the Chi-square test...
November 28, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29111151/experimental-optimization-of-lornoxicam-liposomes-for-sustained-topical-delivery
#4
Joshny Joseph, Vedha Hari B N, Ramya Devi D
The purpose of the present investigation is to formulate liposomes of Lornoxicam for topical delivery using Central Composite Design, to provide a sustained release of the drug and thereby extend its elimination half-life. Liposomes were prepared by thin film hydration method with pH induced vesiculation. The liposomes were assessed for their particle size, charge, morphology and drug entrapment and characterized using TGA-DSC and FTIR analysis, to assess the interaction between the drug and excipients. The in vitro release study was performed using modified USP dissolution apparatus-I using three different dissolution media and the ex vivo release study was performed using goat skin...
October 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29056774/glucocorticoid-management-in-rheumatoid-arthritis-morning-or-night-low-dose
#5
REVIEW
Sabrina Paolino, Maurizio Cutolo, Carmen Pizzorni
Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up-regulation of the immune/inflammatory reaction has been shown more effective when exogenous glucocorticoid administration is managed with a night-time-release formulation...
2017: Reumatologia
https://www.readbyqxmd.com/read/29030184/screening-of-drug-sericin-solid-dispersions-for-improved-solubility-and-dissolution
#6
Nitin H Salunkhe, Namdeo R Jadhav, Harinath N More, Adhikrao D Jadhav
The aim of present attempt deals with preparation of binary dispersion of sericin, waste of sericulture industry in order to enhance solubility and dissolution of poorly soluble drugs. Solid dispersions (SDs) of BCS-II drugs were prepared by spray drying, solvent evaporation, ball milling and physical mixing in ratio of drug:sericin (1:0.5, 1:1, 1:1.5, 1:2, 1:2.5 and 1:3). Further, SDs were investigated by solubility, ATR-FTIR, XRD, DSC, micromeritics and tablettability, surface morphology and in-vitro dissolution...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29026298/therapeutic-effects-of-lornoxicam-loaded-nanomicellar-formula-in-experimental-models-of-rheumatoid-arthritis
#7
Hebatullah Samy Helmy, Ayman E El-Sahar, Rabab H Sayed, Rehab Nabil Shamma, Alaa Hamed Salama, Eman Maher Elbaz
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce the side effects of various drugs. The objective of the present study was to compare the therapeutic efficacy of systemic administration of lornoxicam-loaded nanomicellar formula (LX-NM) with that of free LX. MATERIALS AND METHODS: The LX-loaded mixed polymeric nanomicellar formula was prepared by direct equilibrium technique...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28971636/comparison-between-lornoxicam-and-paracetamol-for-pain-management-after-dilation-and-curettage-for-abortion
#8
Susana Mustafa-Mikhail, Sharon Assaraf, Philippe Abecassis, Hanin Dabaja, Samer Jarrous, Salim Hadad, Lior Lowenstein
BACKGROUND: Management of postoperative pain has become a growing concern, even for minor gynecological procedures. Proper postoperative pain management has been shown to lead to earlier mobilization, shortened hospital stay, and increased patient satisfaction. The optimal means of reducing the pain of pregnancy termination has not yet been determined. OBJECTIVES: To compare the efficiency in pain management of two drugs, lornoxicam and paracetamol, given intravenously postoperatively to women who underwent abortion with dilation and curettage...
September 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28948909/transdermal-lipid-nanocarriers-a-potential-delivery-system-for-lornoxicam
#9
Sandipan Dasgupta, Subhabrata Ray, Sanjay Dey, Paulami Pal, Bhaskar Mazumder
BACKGROUND: Lornoxicam, is a NSAID of the oxicam class. Its short duration of action owing to rapid elimination and gastrointestinal side effects limits its usefulness when administered orally. OBJECTIVE: The primary objective of the proposed work is to develop suitable lipid nanocarriers for transdermal delivery of Lornoxicam with increased drug residence time at local site of inflamation and in systemic circulation, overcoming undesired gastrointestinal side effects...
2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28868303/adjuvants-to-local-anesthetics-current-understanding-and-future-trends
#10
EDITORIAL
Amlan Swain, Deb Sanjay Nag, Seelora Sahu, Devi Prasad Samaddar
Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action...
August 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28751939/a-comparative-assessment-of-postoperative-analgesic-efficacy-of-lornoxicam-versus-tramadol-after-open-reduction-and-internal-fixation-of-mandibular-fractures
#11
Ankesh Dilip Jain, Ravisankar Vsm, Siva Bharani Ksn, Sudheesh Km, Nisha Tewathia
Pain after any surgical procedure is inevitable but can be controlled by administration of analgesics in most cases. Postoperative pain after surgical treatment of mandibular fractures can be treated by nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. The purpose of this study is to critically compare the postoperative analgesic efficacy of small doses of intravenous TRAMADOL (opioid analgesic) versus LORNOXICAM (NSAID) in patients with mandibular trauma undergoing open reduction and internal fixation (ORIF) and to assess the presence of any adverse effects due to NSAID or opioid use...
September 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28711030/carvedilol-can-attenuate-histamine-induced-paw-edema-and-formaldehyde-induced-arthritis-in-rats-without-risk-of-gastric-irritation
#12
Afaf Sayed Osman, Dina Ahmed Labib, Mahmoud M Kamel
BACKGROUND AND AIM: Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol and to study its effect on gastric mucosa. EXPERIMENTAL APPROACH: Lornoxicam (1.3mg/kg) or carvedilol (10mg/kg) was administrated orally 1h before histamine injection into animals of a histamine-induced paw edema model and orally daily for 11days into animals of a formaldehyde-induced arthritis model...
July 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28639085/nonsteroid-anti-inflammatory-therapy-suppresses-the-development-of-proliferative-vitreoretinopathy-more-effectively-than-a-steroid-one
#13
Marina V Tikhonovich, Aleksei K Erdiakov, Svetlana A Gavrilova
PURPOSE: This study proves the possibility of targeted use of the nonsteroidal anti-inflammatory drug lornoxicam to prevent the development of proliferative vitreoretinopathy (PVR). Triamcinolone acetonide (TA) was selected as a reference substance. METHODS: Wistar rats (N = 400) were used. PVR was modeled by intravitreal injection of dispase or concanavalin A. Lornoxicam or TA intravitreal administration was performed 20 min later. On the second and the third day, drugs were administrated systemic...
June 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28449627/lornoxicam-use-to-reduce-the-pain-associated-with-propofol-injection
#14
Nihal Başak, Yakup Aksoy, Ayhan Kaydu, Ömer Fatih Şahin
AIM: To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection. MATERIAL AND METHOD: Approval for this study was granted by the ethics committee of our hospital. Using a computer randomisation software, 120 patients undergoing elective surgery were assigned to four equal groups. In Group I (control group), immediately before anaesthesia induction, 10 ml of isotonic 0.9% NaCl solution (placebo) was administered intravenously (IV)...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28338301/analgesia-for-patients-undergoing-shockwave-lithotripsy-for-urinary-stones-a-systematic-review-and-meta-analysis
#15
REVIEW
Omar M Aboumarzouk, Rami Hasan, Ali Tasleem, Martin Mariappan, Rachael Hutton, John Fitzpatrick, Laura Beatty, Gareth E Jones, Tarik Amer
BACKGROUND: Shock wave lithotripsy (SWL) is the first line treatment modality for a significant proportion of patients with upper urinary tracts stones. Simple analgesics, opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are all suitable agents but the relative efficacy and tolerability of these agents is uncertain. OBJECTIVES: To determine the efficacy of the different types of analgesics used for the control of pain during SWL for urinary stones. MATERIALS AND METHODS: We searched the Cochrane Renal Group's Specialised Register, MEDLINE, EMBASE and also hand-searched reference lists of relevant articles (Figure-1)...
May 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28283842/a-pharmaceutical-study-on-lornoxicam-fast-disintegrating-tablets-formulation-and-in-vitro-and-in-vivo-evaluation
#16
Mohamed Yousif Moutasim, Aliaa Nabil ElMeshad, Mohamed Ahmed El-Nabarawi
Lornoxicam is an anti-inflammatory drug used to relieve rheumatoid arthritis pain, but the low water solubility and bitter taste of the drug present challenges for formulation as fast disintegrating tablets (FDTs). Complexation of the drug with β-cyclodextrin was initially carried out to increase the drug solubility and to mask its bitter taste. Tablets were prepared by direct compression of drug complex (DC), F-Melt, mannitol, crospovidone, and sodium starch glycolate (SSG). FDTs were characterized in terms of disintegration time (DT) and dissolution...
June 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#17
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28235624/design-of-novel-injectable-in-situ-forming-scaffolds-for-non-surgical-treatment-of-periapical-lesions-in-vitro-and-in-vivo-evaluation
#18
Rehab N Shamma, Nermeen A Elkasabgy, Azza A Mahmoud, Shaimaa I Gawdat, Mohamed M Kataia, Mohamed A Abdel Hamid
Periapical lesions are considered one of the common pathological conditions affecting alveolar bone. The primary focus of this study was to investigate the effectiveness of formulating an injectable in-situ forming scaffold-loaded with risedronate (bone resorption inhibitor) and with lornoxicam (anti-inflammatory drug) for the non-surgical treatment of periapical lesions. The scaffolds were prepared using solvent-induced phase inversion technique. Two insoluble copolymers were investigated namely; PLGA (ester-terminal) and PLGA-A (acid-terminal), additionally, SAIB was added as a high viscosity water-insoluble carrier...
April 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28176487/lornoxicam-immediate-release-tablets-formulation-and-bioequivalence-study-in-healthy-mediterranean-volunteers-using-a-validated-lc-ms-ms-method
#19
Abdel Naser Zaid, Ayman Mousa, Nidal Jaradat, Rana Bustami
This study aimed to demonstrate interchangeability between 2 lornoxicam tablet formulations under fasting conditions among Mediterranean Arabs by using a newly validated high-pressure liquid chromatography-tandem mass spectrometry method. A single-oral solid dosage form (8 mg/tablet), randomized, open-label, 2-way crossover study was conducted on 30 healthy male volunteers. Blood samples were collected prior to dosing and over a 24-hour period, and the washout period was 9 days. Statistical comparison of the main pharmacokinetic parameters showed no significant difference between generic and branded products...
February 8, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28111731/comparison-of-lornoxicam-and-low-dose-tramadol-for-management-of-post-thyroidectomy-pain
#20
Ali Yücel, Alper Yazıcı, Togay Müderris, Fatih Gül
OBJECTIVES: The present study sought to compare the analgesic efficacy and adverse effects of intravenous (IV) lornoxicam and tramadol to investigate if lornoxicam is a reasonable alternative to a weak opioid for post-thyroidectomy pain. METHODS: Fifty patients of American Society of Anesthesiologists class I or II, 18 to 65 years of age, and who underwent thyroidectomy were assigned to 2 groups in a randomized manner. Group L received 8 mg of lornoxicam IV and Group T received 1 mg/kg of tramadol IV at conclusion of the operation...
October 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
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