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peptic ulcer perforation

K Thorsen, J A Søreide, K Søreide
BACKGROUND: Perforated peptic ulcer (PPU) is a surgical emergency associated with high short-term mortality. However, studies on long-term outcomes are scarce. Our aim was to investigate long-term survival after surgery for PPU. MATERIALS AND METHODS: A population-based, consecutive cohort of patients who underwent surgery for PPU between 2001 and 2014 was reviewed, and the long-term mortality was assessed. Survival was investigated by univariate analysis (log-rank test) and displayed using Kaplan-Meier survival curves...
October 12, 2016: World Journal of Surgery
Daniel Jin Keat Lee, MaDong Ye, Keith Haozhe Sun, Vishalkumar G Shelat, Aaryan Koura
Introduction. The aim of this study was to compare the outcomes between laparoscopic and open omental patch repair (LOPR versus OR) in patients with similar presentation of perforated peptic ulcer (PPU). The secondary aim was to evaluate the outcomes according to the severity of peritonitis. Methods. All patients who underwent omental patch repair at two university-affiliated institutes between January 2010 and December 2014 were reviewed. Matched cohort between LOPR and OR groups was achieved by only including patients that had ulcer perforation <2 cm in size and symptoms occurring <48 hours...
2016: Surgery Research and Practice
Emmanuel A Agaba, Tarunjeet Klair, Ojinika Ikedilo, Prathiba Vemulapalli
INTRODUCTION: The discovery of Helicobacter pylori (H. pylori) as the culprit in peptic ulcer disease (PUD) has revolutionized its management. Despite the presence of effective drug treatments and an increased understanding of its etiology, the percentage of patients who require emergent surgery for complicated disease remains constant at 7% of hospitalized patients. This study aims at reviewing the incidence of complicated PUD and analyze changes in surgical management. PATIENTS AND METHODS: From January 2002 to September 2012, records of all patients with a clinical or radiologic diagnosis of perforated PUD were evaluated...
October 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Andrzej Ż Żyluk, Zbigniew Szlosser
Non-traumatic perforation of the digestive tract occurs most often in the duodenum and stomach (peptic ulcer), as well as the colon (diverticulitis, cancer or ischemic lesions). Perforation of the small bowel is very rare. The Authors of the study presented a case of proximal jejunum perforation, which occurred in a patient with a history of duodenal peptic ulcer disease. Diagnosis posed no difficulties, and treatment included the excision of the ulceration and suturing of the bowel. The patient recovered without complications and the histological examination failed to reveal the nature of the ulcer...
September 1, 2016: Polski Przeglad Chirurgiczny
S K Natarajan, D Chua, K Anbalakan, V G Shelat
PURPOSE: Marginal ulcer (MU) is defined as ulcer on the jejunal side of the gastrojejunostomy (GJ) anastomosis. Most MUs are managed medically but those with complications like bleeding or perforation require intervention. It is recommended that GJ anastomosis be revised in patients with MU perforation (MUP). The aim of this case series is to study the clinical presentation and management of MUP. METHODS: Three hundred and thirty-two patients who underwent emergency surgery for perforated peptic ulcer at a single center were studied over a period of 5 years...
September 12, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Michael H K Nguyen, Krista M Isaac, Rebecca Dougherty
Gastrointestinal perforations are a complication of 2-10% of duodenal ulcers. There are a variety of etiologies associated with duodenal ulcer formation and its complications. Corticosteroid use is associated with an increased risk of duodenal ulcer perforation, with the first documented case in 1950. Other important medications associated with perforation include NSAIDS and opioids. Beyond medication, one of the most common disease processes, chronic obstructive pulmonary disease (COPD), has been found to be associated with peptic ulcer disease...
2016: Journal of Community Hospital Internal Medicine Perspectives
Khalid Hussain, Aimel Munir, Madiha Saeed Wahla, Jovaria Masood
No abstract text is available yet for this article.
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
S G Belov, T I Tamm, I N Mamontov, V V Nepomnyashchiy
No abstract text is available yet for this article.
March 2016: Klinichna Khirurhiia
Abhishek Agarwal, Sanchit Jain, L N Meena, Sumita A Jain, Lakshman Agarwal
BACKGROUND: The major complications of peptic ulcer are hemorrhage, perforation and gastric outlet obstruction with perforation occurring in about 2-10% of patients. Patients with perforated peptic ulcer still have a high rate of morbidity and mortality and to improve the outcomes it is important to stratify the patients into different categories. AIMS: To evaluate the accuracy of Boey scoring system in predicting postoperative morbidity and mortality in patients operated for peptic perforation...
October 2015: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
Shanjun Tan, Guohao Wu, Qiulin Zhuang, Qiulei Xi, Qingyang Meng, Yi Jiang, Yusong Han, Chao Yu, Zhen Yu, Ning Li
INTRODUCTION: The role of laparoscopic surgery in the repair for peptic ulcer disease is unclear. The present study aimed to compare the safety and efficacy of laparoscopic versus open repair for peptic ulcer disease. METHODS: Randomized controlled trials (RCTs) comparing laparoscopic versus open repair for peptic ulcer disease were identified from MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and references of identified articles and relevant reviews...
September 2016: International Journal of Surgery
Mahdi Alemrajabi, Saeed Safari, Adnan Tizmaghz, Fatemeh Alemrajabi, Ghazaal Shabestanipour
INTRODUCTION: The mainstay of treatment for perforated peptic ulcer is Omental patch closure. With the advent of laparoscopic surgery, this approach is being used for the treatment of perforated peptic ulcer. The aim of this study was to evaluate the outcome of laparoscopy in Firoozgar general hospital over a period of 18 months. The outcome of the laparoscopic approach and the associated morbidity and mortality, operation time, conversion rate and hospital stay were assessed. METHODS: A prospective analysis of 29 consecutive patients (mean age 37...
June 2016: Electronic Physician
Sergio Gentilli, Alberto Oldani, Manuela Zanni, Erika Ferreri, Alfonso Terrone, Guido Valente, Pietro Occhipinti
AIM: Gastro-splenic fistula is a rare entity in which malignant tumors are the primary cause, followed by perforated peptic ulcers and Crohn's disease. CASE REPORT: A 66 years old patient undergoing chemotherapy for gastric large cells B lymphoma presented fever, fatigue and worsening of general conditions. A CT scan showed the presence of an abdominal abscess resulting from a pathological communication between stomach and spleen. RESULTS: En - bloc splenectomy and gastric wedge resection was performed; gastric wall was sutured with a linear stapler...
2016: Annali Italiani di Chirurgia
Helena Reusens, Martine Dassonville, Henri Steyaert
Introduction A perforated peptic ulcer (PPU) is a rare but major complication of gastroduodenal peptic ulcer disease. Literature is scarce on this subject in the pediatric population and most articles describe a surgical treatment by laparotomy. We aim to review all our cases of pediatric PPU treated over the past 16 years and compare these to literature to deduce potential benefits and disadvantages regarding laparoscopic treatment of PPU in children. Materials and Methods A retrospective study of all cases of PPU treated at the Lenval Hospital in Nice (France) and the Queen Fabiola University Hospital for Children in Brussels (Belgium) between 1998 and 2015 was performed...
July 25, 2016: European Journal of Pediatric Surgery
Sevgi Buyukbese Sarsu
BACKGROUND: The chronic use of synthetic cannabinoids (SCs) which has become an increasingly prevalent problem can rarely cause gastric and duodenal ulcer because of their effects on gastric secretion and emptying. Since peptic ulcer disease (PUD) is a rarely seen entity in patients who consult to the emergency service with complaints of abdominal pain, most of the physicians do not suspect of this clinical diagnosis. Perforation is a mortal complication of PUD, and early diagnosis and emergency surgery are life-saving procedures...
December 2016: International Journal of Emergency Medicine
Mumtaz Ibrahim, Dildar Hussain, Seema Waheed, Raazia Tahir, Ghulam Haider, Nauvan Ali, Shahid Latif Sarfraz
A 32 years old gentleman, presented in emergency department, with complaints of sudden onset of severe upper abdominal pain, associated with nausea and vomiting. He was a known case of acid peptic disease. His abdominal examination showed signs of peritonitis. X-ray chest showed pneumoperitoneum, with dextrocardia. Ultrasound showed situs inversus. Exploration confirmed the diagnosis of perforated ulcer and situs inversus. Grahm's patch repair of perforation was done. His postoperative recovery was smooth.
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
Young Kwang Shim, Nayoung Kim
Despite decreasing Helicobacter pylori prevalence, the prevalence of peptic ulcer disease is increasing in the aged population, mainly due to increasing use of NSAIDs to manage pain and inflammation. In addition, low dose aspirin is employed as an anti-coagulant for those who have suffered or are at high risk of ischemic stroke and cardiovascular disease. However, NSAIDs and aspirin are injurious to mucosa of stomach and duodenum. NSAID-induced inhibition of mucosal prostaglandin synthesis is thought to be a major mechanism of gastrointestinal mucosal injury...
June 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Ping-Lien Lay, Hsin-Hung Huang, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu Huang, Hsuan-Hwai Lin
BACKGROUND: Although surgical intervention is the favorable treatment modality for perforated peptic ulcer, nonsurgical treatment is another option. The aim of this study is to analyze the results of conservative treatment for perforated peptic ulcer. METHODS: Between 2003 and 2014, 403 patients were admitted to our hospital for perforated peptic ulcer, and 383 patients underwent surgery, whereas 20 were allocated to conservative treatment. The results of nonsurgical intervention in these patients were analyzed retrospectively...
August 2016: American Journal of Emergency Medicine
Gail T Tominaga, Kristan L Staudenmayer, Shahid Shafi, Kevin M Schuster, Stephanie A Savage, Steven Ross, Peter Muskat, Nathan T Mowery, Preston Miller, Kenji Inaba, Mitchell Jay Cohen, David Ciesla, Carlos V R Brown, Suresh Agarwal, Michel B Aboutanos, Garth H Utter, Marie Crandall
No abstract text is available yet for this article.
September 2016: Journal of Trauma and Acute Care Surgery
Ida Lolle, Morten Hylander Møller, Steffen Jais Rosenstock
OBJECTIVE: Mortality rates in complicated peptic ulcer disease are high. This study aimed to examine the prognostic importance of ulcer site in patients with peptic ulcer bleeding (PUB) and perforated peptic ulcer (PPU). MATERIALS AND METHODS: HASH(0x3805240) DESIGN: a nationwide cohort study with prospective and consecutive data collection. POPULATION: all patients treated for PUB and PPU at Danish hospitals between 2003 and 2014...
October 2016: Scandinavian Journal of Gastroenterology
H Malmi, H Kautiainen, L J Virta, M A Färkkilä
BACKGROUND: Incidence and complications of peptic ulcer disease (PUD) have declined, but mortality from peptic ulcer bleeding has remained unchanged. The few recent studies on mortality associated with both uncomplicated and complicated patients with peptic ulcer disease provide contradictory results. AIMS: To evaluate short- and long-term mortality, and the main causes of death in peptic ulcer disease. METHODS: In this retrospective epidemiologic cohort study, register data on 8146 adult patients hospitalised with peptic ulcer disease during 2000-2008 were collected in the capital region of Finland...
August 2016: Alimentary Pharmacology & Therapeutics
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