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topical hyaluronic acid sagging

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https://www.readbyqxmd.com/read/28247017/topical-stabilized-retinol-treatment-induces-the-expression-of-has-genes-and-ha-production-in-human-skin-in-vitro-and-in-vivo
#1
Wen-Hwa Li, Heng-Kuan Wong, José Serrano, Manpreet Randhawa, Simarna Kaur, Michael D Southall, Ramine Parsa
Skin Aging manifests primarily with wrinkles, dyspigmentations, texture changes, and loss of elasticity. During the skin aging process, there is a loss of moisture and elasticity in skin resulting in loss of firmness finally leading to skin sagging. The key molecule involved in skin moisture is hyaluronic acid (HA), which has a significant water-binding capacity. HA levels in skin decline with age resulting in decrease in skin moisture, which may contribute to loss of firmness. Clinical trials have shown that topically applied ROL effectively reduces wrinkles and helps retain youthful appearance...
May 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/16543853/caring-for-hiv-positive-and-aging-patients-with-associated-facial-lipoatrophy
#2
REVIEW
Pamela Esch
Facial lipoatrophy is characterized by fat loss and redistribution. It is a natural, biological phenomenon that occurs over time, presenting as mild-to-moderate volume depletion that gives the skin the appearance of sagging. More recently, highly active antiretroviral therapy, introduced for the management of human immunodeficiency virus, has been associated with moderate-to-severe facial lipoatrophy, and is characterized by sunken cheeks, accentuated nasolabial folds, and protruding musculature and bones. Furthermore, the consequences of facial lipoatrophy have been found to substantially impact patient quality of life...
January 2006: Plastic Surgical Nursing
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