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topical hyaluronic acid wrinkle

Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
Elizabeth T Makino, Priscilla Tan, Kun Qian, Michael Babcock, Rahul C Mehta
<p>Key features of lip aging include loss of volume, color, and definition as well as increases in lines/wrinkles and uneven skin texture. A single-center, open-label clinical study was conducted to assess the efficacy and tolerability of a novel, topical two-step lip treatment (HA5 LS) in female subjects presenting with mild to moderate lip dryness and mild to severe lip condition. Subjects were instructed to apply HA5 LS at least three times a day to ensure coverage 8 hours a day for four weeks. Clinical assessments for efficacy and tolerability were conducted at baseline, baseline post-application, week 2, and week 4...
April 1, 2017: Journal of Drugs in Dermatology: JDD
Wen-Hwa Li, Heng-Kuan Wong, José Serrano, Manpreet Randhawa, Simarna Kaur, Michael D Southall, Ramine Parsa
Skin Aging manifests primarily with wrinkles, dyspigmentations, texture changes, and loss of elasticity. During the skin aging process, there is a loss of moisture and elasticity in skin resulting in loss of firmness finally leading to skin sagging. The key molecule involved in skin moisture is hyaluronic acid (HA), which has a significant water-binding capacity. HA levels in skin decline with age resulting in decrease in skin moisture, which may contribute to loss of firmness. Clinical trials have shown that topically applied ROL effectively reduces wrinkles and helps retain youthful appearance...
May 2017: Archives of Dermatological Research
Antonietta Stellavato, Luisana Corsuto, Antonella D'Agostino, Annalisa La Gatta, Paola Diana, Patrizia Bernini, Mario De Rosa, Chiara Schiraldi
Hyaluronic Acid (HA)-based dermal formulations have rapidly gained a large consensus in aesthetic medicine and dermatology. HA, highly expressed in the Extracellular Matrix (ECM), acts as an activator of biological cascades, stimulating cell migration and proliferation, and operating as a regulator of the skin immune surveillance, through specific interactions with its receptors. HA may be used in topical formulations, as dermal inducer, for wound healing. Moreover, intradermal HA formulations (injectable HA) provide an attractive tool to counteract skin aging (e...
2016: PloS One
Macrene Alexiades
Jasmonates are plant-derived hormones from linoleic acid that were originally isolated from jasmine, and which are involved in plant stress regulation, wound repair and defense. They have been demonstrated through in vitro and in vivo studies to possess anti-neoplastic properties. Most recently, a novel jasmonate analog was developed, tetrahydrojasmonic acid (LR2412), which possesses favorable characteristics for cutaneous application and which induces improvements in epidermal hyaluronic acid and thickness...
February 2016: Journal of Drugs in Dermatology: JDD
Vic A Narurkar, Sabrina G Fabi, Vivian W Bucay, Ruth Tedaldi, Jeanine B Downie, Joshua A Zeichner, Kimberly Butterwick, Amy Taub, Kuniko Kadoya, Elizabeth T Makino, Rahul C Mehta, Virginia L Vega
Skin aging is a combination of multifactorial mechanisms that are not fully understood. Intrinsic and extrinsic factors modulate skin aging, activating distinctive processes that share similar molecular pathways. One of the main characteristics of youthful skin is its large capacity to retain water, and this decreases significantly as we age. A key molecule involved in maintaining skin hydration is hyaluronic acid (HA). Concentration of HA in the skin is determined by the complex balance between its synthesis, deposition, association with cellular structures, and degradation...
January 2016: Journal of Drugs in Dermatology: JDD
Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, Chiaki Ishizaki
BACKGROUND: Aloe is known for its topical use for treating wounds and burns. Many previous studies reported the healing effects of Aloe vera. However, there are few clinical studies on the effect of orally administered A. vera gel on the skin. Aloe sterols are a type of plant sterols that have the capability to regulate the metabolism of glucose and lipids. In a recent study, we confirmed that ingested Aloe sterols reached the peripheral tissues through the bloodstream. However, their influence on dermal fibroblasts has not been investigated...
2015: Clinical, Cosmetic and Investigational Dermatology
Joy D Wisniewski, Dana L Ellis, Mary P Lupo
Cosmetic patients are looking for a more youthful appearance without spending a lot of money, feeling any pain, or experiencing any postprocedure downtime. New cosmeceutical therapies can be used adjuvant to chemical peels, lasers, and injectables, making antiaging regimens less painful and requiring less postprocedural healing time. Adjunctive agents can be used to enhance chemical peels and decrease postinflammatory hyperpigmentation (PIH). Topical retinoids used prior to ablative laser treatments can aid in faster postprocedure healing and reepithelialization...
September 2014: Cutis; Cutaneous Medicine for the Practitioner
Do Hyun Lee, In Young Oh, Kyo Tan Koo, Jang Mi Suk, Sang Wook Jung, Jin Oh Park, Beom Joon Kim, Yoo Mi Choi
BACKGROUND: Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon. OBJECTIVE: We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet). MATERIALS AND METHODS: In total, 23 Korean women (age range: 39-59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study...
February 2015: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Gülengül Duman, İsmail Aslan, A Yekta Özer, İbrahim İnanç, Alpay Taralp
The moisture-imparting effect of sodium hyaluronate (Na-HA) was investigated in liposome, gel and lipogelosome topical formulations. Sixteen liposome formulations were prepared with or without Na-HA (45 kDa) using various ratios of dimyristoylphosphatidylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphatidylglycerol, dipalmitoylphosphatidylcholine and phospholipon 100H. The liposomes were characterized in terms of their structure, composition, zeta potential, Na-HA-entrapment capacity and stability. In particular, scanning electron microscopy, polarized light microscopy, dynamic light scattering and atomic force microscopy were utilized to probe appearance, size and size distribution and lamellarity...
December 2014: Journal of Liposome Research
S Manjula Jegasothy, Valentina Zabolotniaia, Stephan Bielfeldt
BACKGROUND: The aim of this study was to evaluate the efficacy of a new topical low molecular nano-hyaluronic acid preparation in treating wrinkles, skin hydration, and skin elasticity in humans. METHODS: Thirty-three women with an average age of 45.2 were studied for a period of eight weeks to measure the anti-wrinkle efficacy of a new nano-hyaluronic acid. The measurements were performed in the periorbital regions by investigating the three-dimensional structure using a DermaTOP for wrinkles, Corneometer for skin hydration, Cutometer for skin elasticity, and a Chroma Meter for erythema...
March 2014: Journal of Clinical and Aesthetic Dermatology
Robert Bublak
No abstract text is available yet for this article.
April 4, 2013: MMW Fortschritte der Medizin
Ana Rita Rodrigues-Barata, Francisco M Camacho-Martínez
BACKGROUND: Soft tissue augmentation is one of the most frequent techniques in cosmetic dermatology. Nowadays, there are a high number of available materials. Nonanimal hyaluronic acid (HA) is one of most useful fillers for lip augmentation and for treating nasolabial folds, marionette lines, and the dynamic wrinkles of the upper face. OBJECTIVE: To evaluate the type and management of undesirable effects of nonanimal reticulated or stabilized HA observed in our cosmetic unit in the past 3 years...
April 2013: Journal of Drugs in Dermatology: JDD
Sae Hoon Chin, Jin Sik Burm, Youn Wha Kim
This study assessed selective dermal rejuvenation using sequential intradermal injections of carbon dioxide and hyaluronic acid as a treatment of facial wrinkles. An injection device was designed. After topical anesthesia, 0.1-mL carbon dioxide was gently injected intradermally so as to spread diffusely. A volume of 0.01- to 0.02-mL diluted hyaluronic acid was sequentially injected until the skin rose slightly. Overlapping injections were performed at 3 to 5 mm intervals. This process was repeated until the wrinkles were smoothened...
June 2013: Annals of Plastic Surgery
Theda C Kontis
Perhaps the most significant change in facial rejuvenation in the last 10 years has been the introduction of nonsurgical treatments for the relaxation of facial wrinkles and for the restoration of lost volume. Fillers such as paraffin and silicone have been used in the past for volume restoration, but only recently have new fillers been developed whose safety and efficacy have been supported by clinical research. The introduction of hyaluronic acid (HA) fillers in 2003 began the filler revolution and paved the way for development of biostimulatory and permanent materials...
January 2013: JAMA Facial Plastic Surgery
Benjamin Ascher, Chantal Fanchon, Leila Kanoun-Copy, Anne Bouloc, Florence Benech
INTRODUCTION: A monocentre double-blind two parallel group clinical study was conducted to assess whether a new skincare regimen containing retinol, adenosine and hyaluronic acid, applied after the injection of botulinum toxin A to the glabellar area, provided a beneficial effect. MATERIAL AND METHODS: Standardised photographs acquired using LifeViz cameras and zoomed pictures of the glabella and of the crow's feet areas were analysed with automatic well-defined procedures...
October 2012: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Tatjana Pavicic, Gerd G Gauglitz, Peter Lersch, Khadija Schwach-Abdellaoui, Birgitte Malle, Hans Christian Korting, Mike Farwick
BACKGROUND: Due to its strong water-binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. Native HA is proposed to help the skin to retain and maintain elasticity, turgor and moisture. OBJECTIVE: To observe the efficacy of topical application of 0.1% hyaluronan formulations of different molecular weights (MW) (50, 130, 300, 800 and 2000 kDa, respectively) in the periocular area as anti-wrinkle treatment. MATERIAL AND METHODS: Seventy-six female subjects between 30 and 60 years of age with clinical signs of periocular wrinkles applied one of the formulations twice-daily to the area of interest in a randomized fashion for 60 days...
September 2011: Journal of Drugs in Dermatology: JDD
Yu Yu Shu, Howard I Maibach
Aging of the skin is associated with skin thinning, atrophy, dryness, wrinkling, and delayed wound healing. These undesirable aging effects are exacerbated by declining estrogen levels in postmenopausal women. With the rise in interest in long-term postmenopausal skin management, studies on the restorative benefits that estrogen may have on aged skin have expanded. Systemic estrogen replacement therapy (ERT) has been shown to improve some aspects of skin. Estrogen restores skin thickness by increasing collagen synthesis while limiting excessive collagen degradation...
October 1, 2011: American Journal of Clinical Dermatology
Andres Cordero, Gladys Leon-Dorantes, Annick Pons-Guiraud, Anonio Di Pietro, Santiago Vidal Asensi, Barbara Walkiewicz-Cyraska, Radek Litvik, Virginie Turlier, Sophie Mery, Christelle Merial-Kieny
BACKGROUND: Retinaldehyde (RAL) was proven effective in treating photodamaged skin. Topical treatments with specific intermediate-size hyaluronate fragments (HAFi, 50-400 kDa) have been shown to stimulate keratinocytes proliferation and epidermal hyperplasia. The aim of this open, multicentric, international study was to assess the efficacy of the combination RAL-HAFi in the correction of skin photoaging. PATIENTS/METHODS: Either RAL 0.05%-HAFi 0.5% (Eluage® cream; group 1) or RAL 0...
June 2011: Journal of Cosmetic Dermatology
Stacy R Smith, Derek Jones, Jane A Thomas, Diane K Murphy, Frederick C Beddingfield
Many patients elect to have repeat treatments with hyaluronic acid dermal fillers to maintain wrinkle correction, but the clinical performance of these products after repeat treatments has not been formally assessed. The primary objective of this study was to evaluate the effectiveness of Juvéderm injectable gel (Juvéderm Ultra, Juvéderm Ultra Plus, and Juvéderm 30) through 1 year after repeat treatment of nasolabial folds (NLFs) that were previously treated with Juvéderm or Zyplast 6-9 months prior to the repeat treatment...
December 2010: Archives of Dermatological Research
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