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https://www.readbyqxmd.com/read/29053478/%C3%AE-lipoic-acid-as-adjunctive-treatment-for-schizophrenia-an-open-label-trial
#1
Lia Lira Olivier Sanders, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Francisco Vagnaldo Fechine, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Maria Elisabete Amaral de Moraes, Clarissa S Gama, Sheila Seybolt, Eugênio de Moura Campos, Danielle Macêdo, David Freitas de Lucena
PURPOSE/BACKGROUND: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. METHODS/PROCEDURES: In this pilot investigation, we administered ALA (100 mg/d) for 4 months, as an adjunct to antipsychotic medication, to 10 patients with schizophrenia...
October 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29050483/phthalate-induced-toxicity-in-prostate-cancer-cell-lines-and-effects-of-alpha-lipoic-acid
#2
G Kismali, B Yurdakok-Dikmen, O Kuzukiran, P Arslan, A Filazi
OBJECTIVE: The effects of dimethyl phthalate, diethyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, benzylbutyl phthalate, di-2-ethylhexyl phthalate were investigated on human prostate cancer cell lines DU145 and PC3 in vitro. MATERIALS AND METHODS: Standards of dimethyl phthalate, diethyl phthalate, di-isobutyl phthalate, dibutyl phthalate, benzyl butyl phthalate, and di-ethyl hexyl phthalate were used. Alpha lipoic acid was used as antioxidant compound...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29044452/effects-of-alpha-lipoic-acid-on-motor-function-and-antioxidant-enzyme-activity-of-nerve-tissue-after-sciatic-nerve-crush-injury-in-rats
#3
Sarper Kocaoğlu, Özgür Aktaş, Oğuzhan Zengi, Azmi Tufan, Feyza Karagöz Güzey
AIM: Background: Alpha lipoic acid (ALA) that is a strong antioxidant drug is tried for both protection and treatment of various diseases of central and peripheral nervous systems. MATERIAL AND METHODS: Material and Methods: Protective effects of ALA on crush type peripheral nerve injury were evaluated. 28 Sprague-Dawley rats were divided into four groups: In Group 1, sciatic nerve was only explored. Sciatic nerve crush injury was performed after serum physiologic injection intraperitoneally in Group 2, and after ALA injection in Groups 3 and 4...
August 31, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29043297/clinical-efficacy-of-alprostadil-combined-with-%C3%AE-lipoic-acid-in-the-treatment-of-elderly-patients-with-diabetic-nephropathy
#4
Yan Hong, Jianyun Peng, Xiaoping Cai, Xiaoru Zhang, Yifei Liao, Lejian Lan
OBJECTIVE: To evaluate the effect and toxicity of alprostadil combined with thioctic acid injection in the treatment of patients with diabetic nephropathy (DN). METHODS: Sixty two patients with DN were included in this study and randomly divided into control group (n=32) and experiment group (n=30). Patients in the control group were given alprostadil 20ug+NS 100ml ivgtt, qd and patients in the experiment group were given alprostadil 20ug+NS 100ml ivgtt combined with thioctic acid injection of 0...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29037705/stabilization-of-alpha-lipoic-acid-by-complex-formation-with-octenylsuccinylated-high-amylose-starch
#5
Yi-Xuan Li, Eun Young Park, Seung-Taik Lim
The thermal and oxidative stability of alpha-lipoic acid (ALA) in aqueous dispersions containing beta-cyclodextrin (CD), native high amylose (HA) and octenylsuccinylated high amylose (OS) starches (0.1% ALA and 1.0% CD or starch solids) were compared. Both native and modified starches increased the stability of ALA against thermal degradation and oxidation at higher degrees than CD. The OS was more effective in stabilizing ALA than HA. The ALA loss in the dispersions occurred mainly in the supernatant, suggesting that the complex formation of ALA with amylose played a key role in the stabilization...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29031205/protective-effect-of-%C3%AE-lipoic-acid-against-spleen-toxicity-of-dimethylnitrosamine-in-male-mice-antioxidant-and-ultrastructure-approaches
#6
Nahla S El-Shenawy, Reham Z Hamza, Howayda E Khaled
The α-lipoic acid is a soft material and useful for the potential biomedical applications. The study was aimed to assess the potency of α-lipoic acid (ALA) against the toxicity of dimethylnitrosamine (DMN) on spleen of mice by assessing the antioxidants, histopathological and ultrastructure changes. The experiment was achieved on six groups of male mice as following; groups 1, 2, 3, and 4 were served as a control, ALA groups, low dose of DMN (DMN-LD; 2mgkg(-1)) and high dose of DMN (DMN-HD; 4mgkg(-1)). Group 5 was received DMN-LD plus ALA and group 6 was given DMN-HD plus ALA...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031070/nature-based-molecules-combined-with-rivastigmine-a-symbiotic-approach-for-the-synthesis-of-new-agents-against-alzheimer-s-disease
#7
Giulia Nesi, Qiuhe Chen, Simona Sestito, Maria Digiacomo, Xiaohong Yang, Shengnan Wang, Rongbiao Pi, Simona Rapposelli
Starting from nature as original source, new potential agents with pleiotropic activities have been synthesized and evaluated as neuroprotective agents. In this work, novel nature-based hybrids, combining antioxidant motifs with rivastigmine, have been designed and synthesized. The biological results revealed that the new compounds inhibit both AChE and BuChE. In particular, lipoic acid hybrids LA1, LA2, LA3 resulted to be the most potent inhibitors of BuChE showing IC50 values ranging from 340 to 378 nM. Analogously, all the compounds were able to inhibit the self β-amyloid1-42 aggregation...
October 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028075/safety-of-oral-alpha-lipoic-acid-treatment-in-pregnant-women-a-retrospective-observational-study
#8
E Parente, G Colannino, O Picconi, G Monastra
OBJECTIVE: Alpha-lipoic acid is a natural molecule, which directly or by means of its reduced form, dihydrolipoic acid, exerts antioxidant, anti-inflammatory and immunomodulatory activities, very helpful also in preventing miscarriage and preterm delivery. Used as dietary supplement alpha-lipoic acid was demonstrated to be safe for living organisms even when administered at high doses. However, no study was made so far to verify the safety of its continuous administration on a substantial number of pregnant women...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026706/development-of-novel-drug-eluting-stents-for-acute-myocardial-infarction
#9
REVIEW
Doo Sun Sim, Myung Ho Jeong
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction Registry was established in commemoration of the 50(th) anniversary of Korea Circulation Society. Between November 2005 and December 2016, more than 62,000 patients were registered from 50 primary percutaneous coronary intervention (PCI) centers in Korea. DES in AMI may be safe and effective, however, there is concern about increased stent thrombosis after DES implantation in AMI patients, requiring longer-term dual anti-platelet therapy to reduce the risk of late stent thrombosis...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29025653/stepwise-ph-reduction-responsive-polymeric-conjugates-for-enhanced-drug-delivery-to-tumor
#10
Shudi Yang, Ying Wang, Zhaoxiang Ren, Mengtian Chen, Weiliang Chen, Xuenong Zhang
In this research, a charge-conversional polymer, poly-l-lysine-lipoic acid (PLL-LA), was prepared by dimethylmaleic anhydride (DA) modification and applied as a carrier with enhanced cell internalization and intracellular pH- and reduction-triggered doxorubicin (Dox) release. The surface charge of dimethylmaleic anhydride-poly-l-lysine-lipoic acid micelles (DA-PLL-LA) was negative at physiological pH and reversed to positive at the extracellular and intracellular pH of cancer cells. At tumor extracellular pH of 6...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29022246/alpha-lipoic-acid-mitigates-toxic-induced-demyelination-in-the-corpus-callosum-by-lessening-of-oxidative-stress-and-stimulation-of-polydendrocytes-proliferation
#11
Nima Sanadgol, Fereshteh Golab, Hassan Askari, Fatemeh Moradi, Marziyeh Ajdary, Mehdi Mehdizadeh
Multiple Sclerosis (MS), is a disease that degenerates myelin in central nervous system (CNS). Reactive oxygen species (ROSs) are toxic metabolites, and accumulating data indicate that ROSs-mediated apoptosis of oligodendrocytes (OLGs) plays a major role in the pathogenesis of MS under oxidative stress conditions. In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS...
October 12, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29019159/alpha-lipoamide-ameliorates-motor-deficits-and-mitochondrial-dynamics-in-the-parkinson-s-disease-model-induced-by-6-hydroxydopamine
#12
Bo Zhou, Min Wen, Xin Lin, Yun-Hua Chen, Yun Gou, Yong Li, Yi Zhang, Hong-Wei Li, Lei Tang
The precise mechanisms underlying neuronal injury in Parkinson's disease (PD) are not yet fully elucidated; however, evidence from the in vitro and in vivo PD models suggest that mitochondrial dysfunction may play a major role in PD pathogenesis. Alpha lipoamide, a neutral amide derivative of the lipoic acid, is a better cofactor for mitochondrial dehydrogenase with a stronger protective effect on mitochondria than lipoic acid. Identification of these protective effects of alpha lipoamide on mitochondria, together with the evidence that mitochondrial dysfunction plays a critical role in PD, we speculate that alpha lipoamide may exert a protective effect in PD by regulating the mitochondrial function...
October 10, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28993193/%C3%AE-lipoic-acid-inhibits-human-lung-cancer-cell-proliferation-through-grb2-mediated-egfr-downregulation
#13
Lan Yang, Ya Wen, Guoqing Lv, Yuntao Lin, Junlong Tang, Jingxiao Lu, Manqiao Zhang, Wen Liu, Xiaojuan Sun
BACKGROUND: Alpha lipoic acid (α -LA) is a naturally occurring antioxidant and metabolic enzyme co-factor. Recently, α -LA has been reported to inhibit the growth of various cancer cells, but the precise signaling pathways that mediate the effects of α -LA on non-small cell lung cancer (NSCLC) development remain unclear. METHODS: The CCK-8 assay was used to assess cell proliferation in NSCLC cell lines after α -LA treatment. The expression of growth factor receptor-bound protein 2 (Grb2), cyclin-dependent kinase (CDK)-2, CDK4, CDK6, Cyclin D3, Cyclin E1, Ras, c-Raf, epidermal growth factor receptor (EGFR), ERK1/2 and activated EGFR and ERK1/2 was evaluated by western blotting...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28992629/%C3%AE-lipoic-acid-promotes-neurological-recovery-after-ischemic-stroke-by-activating-the-nrf2-ho-1-pathway-to-attenuate-oxidative-damage
#14
Chengmei Lv, Surendra Maharjan, Qingqing Wang, Yongxin Sun, Xu Han, Shan Wang, Zhengchun Mao, Yanming Xin, Bing Zhang
BACKGROUND/AIMS: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying mechanisms of α-LA. METHODS: In vivo study, α-LA was administered intravenously upon reperfusion of transient middle cerebral artery occlusion. Garcia score was used to evaluate neurologic recovery. Infarct volume was examined by TTC staining, and oxidative damage was evaluated by ELISA assay...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28988613/amelioration-of-panadol-induced-nephrotoxicity-via-down-regulation-of-bax-bcl2-ratio-with-some-antioxidants
#15
Nouf Al-Rasheed, Laila M Faddah, Iman H Hasan, Hanaa M Ali, Nawal Al-Rasheed, Nagla F El Oraby, Mahmoud H Mohamed
BACKGROUND: Overdoses of Panadol (APAP) result in hepatic and renal toxicity. Up till now, there is no effective drug for APAP-enhanced nephrotoxicity. This work aims to explore the protective effects of N-acetylcysteine, Thymoquinone (THQ), Curcumin (CUR) and α-Lipoic acid (LA) either alone or in combination against APAP nephrotoxicity, focused on modulation of Bax/Bcl2 pathway. METHODS: APAP was administrated at a single dose then treated with the fore mentioned antioxidants...
May 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28986507/a-conserved-mammalian-mitochondrial-isoform-of-acetyl-coa-carboxylase-acc1-provides-the-malonyl-coa-essential-for-mitochondrial-biogenesis-in-tandem-with-acsf3
#16
Geoffray Monteuuis, Fumi Suomi, Juha M Kerätär, Ali J Masud, Alexander J Kastaniotis
Mitochondrial fatty acid synthesis (mtFAS) is a highly conserved pathway essential for mitochondrial biogenesis. The mtFAS process is required for mitochondrial respiratory chain assembly and function, synthesis of the lipoic acid cofactor indispensable for the function of several mitochondrial enzyme complexes and essential for embryonic development in mice. Mutations in human mtFAS have been reported to lead to neurodegenerative disease. The source of malonyl-CoA for mtFAS in mammals has remained unclear...
October 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28986235/alpha-synuclein-epigenetics-mitochondria-metabolism-calcium-traffic-circadian-dysfunction-in-parkinson-s-disease-an-integrated-strategy-for-management
#17
REVIEW
Oliver T Phillipson
The motor deficits which characterise the sporadic form of Parkinson's disease arise from age-related loss of a subset of dopamine neurons in the substantia nigra. Although motor symptoms respond to dopamine replacement therapies, the underlying disease process remains. This review details some features of the progressive molecular pathology and proposes deployment of a combination of nutrients: R-lipoic acid, acetyl-l-carnitine, ubiquinol, melatonin (or receptor agonists) and vitamin D3, with the collective potential to slow progression of these features...
October 3, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28985617/the-%C3%AE-lipoic-acid-improves-high-fat-diet-induced-cerebral-damage-through-inhibition-of-oxidative-stress-and-inflammatory-reaction
#18
Yang Liu, Qinghua Zhang, Li Wang, Hui Wang, Tao Sun, Hechun Xia, Yi Yang, Li Zhang
This study is to clarify the protective role of α-lipoic acid in high-fat diet-induced cerebral damage mice. The mice were divided into 5 groups: normal control group, high-fat diet (HFD) group, low-dose α-lipoic acid group for prevention, high-dose α-lipoic acid group for prevention, and high-dose α-lipoic acid group for treatment. The groups' weights and blood glucose changes were monitored. We used HE staining to observe morphological changes in the cerebral cortex. The expression levels of the oxidative stress proteins SOD2, catalase, and the inflammatory pathway proteins p-JNK, p-ERK were measured by western blot and immunochemistry...
September 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28984160/r-lipoic-acid-overdosing-affects-platelet-life-span-via-ros-mediated-autophagy
#19
Jing Liu, Qingqing Song, Yanwei Huang, Wu Sun, Dingqiang Lu, Bo Zhou
R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously administered with low-dose ALA (20 mg/kg/d), high-dose ALA (80 mg/kg/d) and saline, respectively. Platelets count and bone marrow smear were evaluated and the expressions of markers related to apoptosis and autophagy were measured...
October 6, 2017: Platelets
https://www.readbyqxmd.com/read/28982027/alpha-lipoic-acid-ala-effects-on-developmental-competence-of-equine-preantral-follicles-in-short-term-culture
#20
R G Gomes, C B Silva, S M González, R L Oliveira, M C Max, L A Lisboa, T R R Barreiros, M M Santos, F D Sarapião, E L Gastal, M M Seneda
The effect of different concentrations of alpha lipoic acid (ALA) on the development and morphology of preantral follicles, as well as the proliferative activity of granulosa cells, was assessed after short-term culture. Ovaries (n = 5) of five seasonal anestrous mares were harvested in a local abattoir. At the laboratory, nine ovarian fragments (5 × 5 × 1 mm) from each animal were used. One fragment was immediately fixed in Bouin and subjected to histological and immunohistochemistry (proliferating cell nuclear antigen, PCNA) analyses (noncultured group; D0 = day 0)...
September 27, 2017: Theriogenology
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