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https://www.readbyqxmd.com/read/28527959/systemic-treatment-patterns-with-advanced-or-recurrent-non-small-cell-lung-cancer-in-japan-a-retrospective-hospital-administrative-database-study
#1
Feng Wang, Sari Mishina, Shinji Takai, T Kim Le, Kenya Ochi, Kotaro Funato, Shozo Matsuoka, Yuichiro Ohe
PURPOSE: Data on the treatment of non-small cell lung cancer (NSCLC) in real-world clinical practice in Japan are limited. This large-scale, retrospective cohort study examined data on patients' characteristics and systemic therapies for advanced or recurrent NSCLC in routine practice in Japan. METHODS: This study used an electronic health records-based database of health claims and Diagnosis Procedure Combination data from 215 consenting hospitals in Japan. Records from April 2008 to September 2015 were analyzed...
May 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28520653/transenteric-ercp-for-treatment-of-choledocholithiasis-after-duodenal-switch
#2
João C D Marchesini, Rafael W Noda, Vitor M Haida, Rodrigo C D L Medeiros, Silvano Sadowski, Manoel Galvão Neto, João B Marchesini, Josemberg M Campos
This article aims to describe step-by-step technique performed with the aid of a video. We report the performance of an endoscopic approach to the biliary tract on 2 patients who had previously undergone duodenal switch (DS). It was successfully performed a laparoscopic-assisted transenteric endoscopic retrograde cholangiopancreatography (ERCP) in both the patients. Although successful experiences with ERCP after Roux-en-Y gastric bypass have been found, few cases of ERCP after DS have been reported. Nevertheless, this is the first study to include a multimedia video with description of details and all technical steps of the transenteric ERCP performed on 2 patients who had previously undergone DS...
May 17, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28515466/disentangling-the-intricate-atomic-short-range-order-and-electronic-properties-in-amorphous-transition-metal-oxides
#3
C A Triana, C Moyses Araujo, R Ahuja, G A Niklasson, T Edvinsson
Solid state materials with crystalline order have been well-known and characterized for almost a century while the description of disordered materials still bears significant challenges. Among these are the atomic short-range order and electronic properties of amorphous transition metal oxides [aTMOs], that have emerged as novel multifunctional materials due to their optical switching properties and high-capacity to intercalate alkali metal ions at low voltages. For decades, research on aTMOs has dealt with technological optimization...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500860/interventions-for-preventing-silent-cerebral-infarcts-in-people-with-sickle-cell-disease
#4
REVIEW
Lise J Estcourt, Patricia M Fortin, Sally Hopewell, Marialena Trivella, Carolyn Doree, Miguel R Abboud
BACKGROUND: Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Silent cerebral infarcts are the commonest neurological complication in children and probably adults with SCD. Silent cerebral infarcts also affect academic performance, increase cognitive deficits and may lower intelligence quotient...
May 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28496395/a-relative-quantitative-positive-negative-ion-switching-method-for-untargeted-lipidomics-via-high-resolution-lc-ms-ms-from-any-biological-source
#5
Susanne B Breitkopf, Stéphane J H Ricoult, Min Yuan, Ying Xu, David A Peake, Brendan D Manning, John M Asara
INTRODUCTION: Advances in high-resolution mass spectrometry have created renewed interest for studying global lipid biochemistry in disease and biological systems. OBJECTIVES: Here, we present an untargeted 30 min. LC-MS/MS platform that utilizes positive/negative polarity switching to perform unbiased data dependent acquisitions (DDA) via higher energy collisional dissociation (HCD) fragmentation to profile more than 1000-1500 lipid ions mainly from methyl-tert-butyl ether (MTBE) or chloroform:methanol extractions...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28489083/exploring-biomolecular-energy-landscapes
#6
Jerelle A Joseph, Konstantin Röder, Debayan Chakraborty, Rosemary G Mantell, David J Wales
The potential energy landscape perspective provides both a conceptual and a computational framework for predicting, understanding and designing molecular properties. In this Feature Article, we highlight some recent advances that greatly facilitate structure prediction and analysis of global thermodynamics and kinetics in proteins and nucleic acids. The geometry optimisation procedures, on which these calculations are based, can be accelerated significantly using local rigidification of selected degrees of freedom, and through implementations on graphics processing units...
May 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28484576/influence-of-geometric-changes-in-the-thoracic-aorta-due-to-arterial-switch-operations-on-the-wall-shear-stress-distribution
#7
Tomohiro Fukui, Hiroaki Asama, Manabu Kimura, Toshiyuki Itoi, Koji Morinishi
BACKGROUND: The transposition of the great arteries (TGA) is one of the most severe congenital heart diseases. The arterial switch operation (ASO) is the preferred procedure to treat TGA. Although numerous reports have shown good results after ASOs, some patients suffer from circulatory system problems following the procedure. One reason for problems post-ASO is the local changes in the curvature and torsion of the thoracic aorta. OBJECTIVE: The influence of these geometric changes on the blood flow field needs to be investigated in detail to consider possible cardiovascular problems after an ASO...
2017: Open Biomedical Engineering Journal
https://www.readbyqxmd.com/read/28482523/switchable-on-off-drug-release-from-gold-nanoparticles-grafted-dual-light-and-temperature-responsive-hydrogel-for-controlled-drug-delivery
#8
Mitra Amoli-Diva, Rasoul Sadighi-Bonabi, Kamyar Pourghazi
A switchable dual light- and temperature-responsive drug carrier using gold nanoparticles (Au NPs)-grafted poly(dimethylacrylamide-co-acrylamide)/poly acrylic acid [P(DMA-co-AAm)/PAAc] hydrogel was prepared by free radical polymerization procedure using N,N-methylenebisacrylamide as cross-linker and ammonium persulfate as initiator. Initial P(DMA-co-AAm) hydrogel and uniformly-distributed stable Au NPs, prepared by reduction of hydrogen tetrachloroaureate (III) hydrate in the presence of trisodium citrate, were synthesized separately...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481757/vermillion-reconstruction-with-anal-verge-transitional-epithelium-turning-things-upside-down
#9
Benjamin Levi, Joseph A Ricci, Matthias B Donelan
Postburn lip deformities pose a significant set of challenges to reconstructive burn surgeons because of the complex anatomy, diverse functions, and specialized nature of the lip tissues. There has been a paucity of literature on restoration of the vermillion to date. The authors report on two patients who suffered burn injuries resulting in significant lip deformities who underwent a novel method of vermillion reconstruction with a full thickness anal verge skin graft. Both patients tolerated the procedure well without complications...
May 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28481427/individual-versus-pseudo-repeatability-in-behaviour-lessons-from-translocation-experiments-in-a-wild-insect
#10
Petri T Niemelä, Niels J Dingemanse
1.Repeatability represents a key parameter in ecological and evolutionary research. Repeatability is underpinned by developmental plasticity and genetic variation but may become biased upwards by repeatable differences in environments to which individuals respond plastically. The extent of upward bias caused by the latter mechanism (causing "pseudo-repeatability") is important yet rarely investigated in ecological research. 2.We repeatedly assayed a key behaviour (flight initiation distance) affecting longevity in a wild cricket population (Gryllus campestris)...
May 8, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28476422/long-term-results-of-anatomic-correction-for-congenitally-corrected-transposition-of-the-great-arteries-a-19-year-experience
#11
Christian P Brizard, Alice Lee, Diana Zannino, Andrew M Davis, Tyson A Fricke, Yves d'Udekem, Igor E Konstantinov, Johann Brink, Michael M H Cheung
OBJECTIVE: The surgical indication, timing, strategy, and surgical technique for anatomic correction of congenitally corrected transposition of the great arteries are challenging. We evaluated the long-term results at The Royal Children's Hospital Melbourne. METHODS: Review of 32 successive anatomic corrections between 1996 and 2015. RESULTS: Twenty-one double-switch (66%), 6 Senning/Bex-Nikaidoh (19%), and 5 Senning/Rastelli (16%) procedures were performed (median age, 1...
April 2, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28476420/cognitive-outcomes-and-health-related-quality-of-life-in-adults-two-decades-after-the-arterial-switch-operation-for-transposition-of-the-great-arteries
#12
David Kalfa, Leïla Kasmi, Nikoletta Geronikola, Johanna Calderon, Virginie Lambert, Emre Belli, Damien Bonnet, Michèle Montreuil
OBJECTIVE: The study objective was to evaluate the cognitive and psychosocial outcomes of young adults who underwent an arterial switch operation for transposition of the great arteries. METHODS: Sixty-seven adults with transposition of the great arteries (aged 22.9 ± 3.3 years) and 43 healthy subjects matched in age, gender, and educational level participated. Global cognitive functioning, psychologic state, and health-related quality of life were evaluated using validated tools...
April 4, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28471282/cost-comparison-of-two-trabecular-micro-bypass-stents-versus-selective-laser-trabeculoplasty-or-medications-only-for-intraocular-pressure-control-for-patients-with-open-angle-glaucoma
#13
John P Berdahl, Anup K Khatana, L Jay Katz, Leon Herndon, Andrew J Layton, Tiffany M Yu, Matthew J Bauer, Louis B Cantor
AIM: Patients with open-angle glaucoma (OAG) whose intraocular pressure is not adequately controlled by one medication have several treatment options in the US. This analysis evaluated direct costs of unilateral eye treatment with two trabecular micro-bypass stents (two iStents) compared to selective laser trabeculoplasty (SLT) or medications only. MATERIALS AND METHODS: A population-based, annual state-transition, probabilistic, cost-of-care model was used to assess OAG-related costs over 5 years...
May 4, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28470994/patient-preference-for-radial-versus-femoral-vascular-access-for-elective-coronary-procedures-the-prevas-study
#14
Marlies M Kok, Marieke G M Weernink, Clemens von Birgelen, Anneloes Fens, Liefke C van der Heijden, Janine A van Til
OBJECTIVES: To explore patient preference for vascular access site in percutaneous coronary procedures, the perceived importance of benefits and risks of transradial access (TRA) and transfemoral access (TFA) were assessed. In addition, direct preference for vascular access and preference for shared decision making (SDM) were evaluated. BACKGROUND: TRA has gained significant ground on TFA during the last decades. Surveys on patient preference have mostly been performed in dedicated TRA trials...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28463624/evaluation-of-robot-guided-minimally-invasive-implantation-of-2067-pedicle-screws
#15
Naureen Keric, Christian Doenitz, Amer Haj, Izabela Rachwal-Czyzewicz, Mirjam Renovanz, Dominik M A Wesp, Stephan Boor, Jens Conrad, Alexander Brawanski, Alf Giese, Sven R Kantelhardt
Objective Recent studies have investigated the role of spinal image guidance for pedicle screw placement. Many authors have observed an elevated placement accuracy and overall improvement of outcome measures. This study assessed a bi-institutional experience following introduction of the Renaissance miniature robot for spinal image guidance in Europe. Methods The medical records and radiographs of all patients who underwent robot-guided implantation of spinal instrumentation using the novel system (between October 2011 and March 2015 in Mainz and February 2014 and February 2016 in Regensburg) were reviewed to determine the efficacy and safety of the newly introduced robotic system...
May 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28462609/the-effects-of-double-gloving-on-microsurgical-skills
#16
Scott A Hardison, Grace Pyon, Audrey Le, Wen Wan, Daniel H Coelho
Objective To determine whether double gloving would negatively affect participants' ability to perform a simulated microsurgical task. Study Design Randomized single-blinded controlled crossover trial. Setting Temporal bone laboratory of an academic otolaryngology department. Subjects and Methods This study involved the simulated insertion of a stapes prosthesis into a model of the ossicular chain under microscopy. Forty-one participants were recruited from our medical and dental school and randomized into 2 groups...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28459576/asymmetric-synthesis-of-second-generation-light-driven-molecular-motors
#17
Thomas van Leeuwen, Wojciech Danowski, Edwin Otten, Sander J Wezenberg, Ben L Feringa
The enantiomeric homogeneity of light-driven molecular motors based on overcrowded alkenes is crucial in their application as either unidirectional rotors or as chiral multistate switches. It was challenging to obtain these compounds as single enantiomers via the established synthetic procedures due to loss of optical purity in the key step, i.e., the Barton-Kellogg olefination reaction. Searching for strategies to avoid racemization, a new class of light-driven molecular motors was designed, synthesized, and studied...
May 1, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28458795/a-systematic-review-of-quality-indicators-for-appropriate-antibiotic-use-in-hospitalized-adult-patients
#18
REVIEW
Marlot C Kallen, Jan M Prins
Many quality indicators for appropriate antibiotic use have been developed. We aimed to make a systematic inventory, including the development methodology and validation procedures, of currently available quality indicators (QIs) for appropriate antibiotic use in hospitalized adult patients. We performed a literature search in the Pubmed interface. From the included articles we abstracted i) the indicators developed ii) the type of infection the QIs applied to iii) study design used for the development of the QIs iv) relation of the QIs to outcome measures v) whether the QIs were validated and vi) the characteristics of the validation cohort...
March 30, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28457240/arrhythmias-following-the-mustard-and-senning-operations-for-dextro-transposition-of-the-great-arteries-clinical-aspects-and-catheter-ablation
#19
REVIEW
Sherrie Joy Baysa, Melissa Olen, Ronald J Kanter
The atrial switch operations, the Mustard and Senning procedures, performed for dextro-transposition of the great arteries, have largely been supplanted by the arterial switch operation. As such, affected patients will only exist for approximately 30 more years. The main arrhythmias in these patients include sinoatrial node dysfunction, intraatrial reentry tachycardia, and sudden death. Device therapy for these patients is well-established, and catheter ablation for atrial tachycardias is highly efficacious...
June 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28451933/long-term-food-tolerance-after-bariatric-surgery-comparison-of-three-different-surgical-techniques
#20
Oscar Cano-Valderrama, Andrés Sánchez-Pernaute, Miguel A Rubio-Herrera, Inmaculada Domínguez-Serrano, Antonio J Torres-García
BACKGROUND: Food tolerance has been related to quality of life after bariatric surgery. However, long-term results about this issue are quite limited. The aim of this study was to evaluate the long-term food tolerance in obese patients submitted to surgery, comparing the results between gastric bypass (GBP), long alimentary modified biliopancreatic diversion (MBPD), and long alimentary modified duodenal switch (MDS). METHODS: A cross-sectional analytic study was performed...
April 28, 2017: Obesity Surgery
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