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https://www.readbyqxmd.com/read/29145512/impact-of-the-surgical-strategy-on-the-incidence-of-c5-nerve-root-palsy-in-decompressive-cervical-surgery
#1
Theresa Krätzig, Malte Mohme, Klaus C Mende, Sven O Eicker, Frank W Floeth
OBJECTIVE: Our aim was to identify the impact of different surgical strategies on the incidence of C5 palsy. BACKGROUND: Degenerative cervical spinal stenosis is a steadily increasing morbidity in the ageing population. Postoperative C5 nerve root palsy is a common complication with severe impact on the patients´ quality of life. METHODS: We identified 1708 consecutive patients who underwent cervical decompression surgery due to degenerative changes...
2017: PloS One
https://www.readbyqxmd.com/read/29136804/an-on-line-coupling-of-nanofibrous-extraction-with-column-switching-high-performance-liquid-chromatography-a-case-study-on-the-determination-of-bisphenol-a-in-environmental-water-samples
#2
Martina Háková, Lucie Chocholoušová Havlíková, Jiří Chvojka, Petr Solich, Dalibor Šatínský
Polyamide 6 nanofiber polymers were used as modern sorbents for on-line solid phase extraction (SPE) coupled with liquid chromatography. The on-line SPE system was tested for the determination of bisphenol A in river water samples. Polyamide nanofibers were prepared using needleless electrospinning, inserted into a mini-column cartridge (5 × 4.6mm) and coupled with HPLC. The effect of column packing and the amount of polyamide 6 on extraction efficiency was tested and the packing process was optimized. The proposed method was performed using a 50-µL sample injection followed by an on-line nanofibrous extraction procedure...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29131356/gluten-sensitivities-and-the-allergist-threshing-the-grain-from-the-husks
#3
REVIEW
J G Burkhardt, A Chapa-Rodriguez, S L Bahna
"Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat...
November 13, 2017: Allergy
https://www.readbyqxmd.com/read/29127657/real-world-cost-savings-demonstrated-by-switching-patients-with-refractory-diabetic-macular-edema-to-intravitreal-fluocinolone-acetonide-iluvien-a-retrospective-cost-analysis-study
#4
Soon W Ch'ng, Alexander J Brent, Theodoros Empeslidis, Vasileios Konidaris, Somnath Banerjee
INTRODUCTION: It is hypothesized that using fluocinolone acetonide (FAc) implants such as Iluvien for the treatment of diabetic macular edema (DME) may reduce the total number of intravitreal injections and clinic visits, resulting in an overall treatment cost reduction. The primary aim of this study is to identify the real-world cost savings achievable in a tertiary National Health Service (NHS) hospital. METHODS: A retrospective cost analysis study was conducted...
November 10, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29124451/current-treatment-concepts-for-iatrogenic-ventriculitis-a-nationwide-survey-in-germany
#5
Niklas von Spreckelsen, Norma Jung, Sergej Telentschak, Jürgen Hampl, Roland Goldbrunner, Stefan Grau
BACKGROUND: Iatrogenic ventriculitis is a common complication of the external ventricular drainage. While the procedure and indications for external ventricular drains (EVD) are highly standardized, the treatment of ventriculitis is not clearly defined. OBJECTIVE: To depict the treatment of iatrogenic ventriculitis currently performed in German hospitals. METHODS: A standardized questionnaire consisting of 18 multiple choice questions, each with the ability to provide additional individual answers, covering the diagnosis and treatment of iatrogenic ventriculitis as well as general handling of EVDs, was sent to 121 neurosurgical hospitals registered in the German Society for Neurosurgery (DGNC)...
November 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29124027/risk-factors-of-on-pump-conversion-during-off-pump-coronary-artery-bypass-graft
#6
Sung Sil Yoon, Jung Hee Bang, Sang Seok Jeong, Jae Hwa Jeong, Jong Soo Woo
Background: Off-pump coronary artery bypass grafting (OPCABG) procedures can avoid the complications of an on-pump bypass. However, some cases unexpectedly require conversion to cardiopulmonary bypass during OPCABG. The risk factors associated with a sudden need for cardiopulmonary bypass were analyzed. Methods: This retrospective study included 283 subjects scheduled for OPCABG from 2001 to 2010. These were divided into an OPCABG group and an on-pump conversion group...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29120358/label-free-biomedical-imaging-using-high-speed-lock-in-pixel-sensor-for-stimulated-raman-scattering
#7
Kamel Mars, De Xing Lioe, Shoji Kawahito, Keita Yasutomi, Keiichiro Kagawa, Takahiro Yamada, Mamoru Hashimoto
Raman imaging eliminates the need for staining procedures, providing label-free imaging to study biological samples. Recent developments in stimulated Raman scattering (SRS) have achieved fast acquisition speed and hyperspectral imaging. However, there has been a problem of lack of detectors suitable for MHz modulation rate parallel detection, detecting multiple small SRS signals while eliminating extremely strong offset due to direct laser light. In this paper, we present a complementary metal-oxide semiconductor (CMOS) image sensor using high-speed lock-in pixels for stimulated Raman scattering that is capable of obtaining the difference of Stokes-on and Stokes-off signal at modulation frequency of 20 MHz in the pixel before reading out...
November 9, 2017: Sensors
https://www.readbyqxmd.com/read/29116413/cardiovascular-risk-factors-after-single-anastomosis-duodeno-ileal-bypass-with-sleeve-gastrectomy-sadi-s-a-new-effective-therapeutic-approach
#8
REVIEW
Antonio Torres, Miguel A Rubio, Ana M Ramos-Leví, Andrés Sánchez-Pernaute
Obesity and its associated comorbidities entail a significantly increased cardiovascular mortality. Therefore, approaching obesity control must include among its aims the reduction of the associated comorbidities and the higher cardiovascular mortality risk and not only weight loss. Many observational studies indicate that bariatric surgery (BS) is associated with a better long-term survival than standard care. Furthermore, in general, these epidemiological studies included patients who underwent gastric bypass (GB), not biliopancreatic diversion/duodenal switch (BPD/DS), so the potential additional benefit of this latter technique remains unknown...
November 7, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29115098/the-subependymal-microvascular-network-revealed-by-endoscopic-fluorescence-angiography
#9
Pierluigi Longatti, Alessandro Boaro, Giuseppe Canova, Alessandro Fiorindi
BACKGROUND: The subependymal vascularization of the cerebral ventricles has been described in anatomical studies on human specimens. Its identification in vivo during neuroendoscopic navigation could have anatomical interest and may lead to a safer ventricular navigation, also avoiding unexpected bleeding. The traditional endoscopic visualization allows the certain identification of only the main vessels. In this study we describe the features of the subependymal vascular network (SEVN) enhanced by sodium fluorescein (SF) angiography...
November 7, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29113760/strengths-weaknesses-and-future-challenges-of-biosimilars-development-an-opinion-on-how-to-improve-the-knowledge-and-use-of-biosimilars-in-clinical-practice
#10
Cristina Scavone, Concetta Rafaniello, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy and safety profiles) features of new biosimilars with their respective reference products. Despite the undeniable advantages of such procedure, some concerns (such as the absence of switching studies or the evaluation of efficacy and safety in all therapeutic indications) still exist about its...
November 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29112661/role-of-insurance-coverage-in-contraceptive-use-after-abortion
#11
M Antonia Biggs, Diana Taylor, Ushma D Upadhyay
OBJECTIVE: To assess postaspiration abortion contraceptive use and the role of insurance coverage for abortion in a state that covers abortion and contraception for low-income women. METHODS: This is a secondary analysis of a previously published prospective study to assess the safety of abortion provision. From 2007 through 2013, women seeking first-trimester aspiration abortion were recruited at 25 clinical facilities within four Planned Parenthood affiliates and Kaiser Permanente of Northern California...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29108895/changes-in-bowel-habits-and-patient-scored-symptoms-after-roux-en-y-gastric-bypass-and-biliopancreatic-diversion-with-duodenal-switch
#12
Khalid Elias, Zakaria Bekhali, Jakob Hedberg, Wilhelm Graf, Magnus Sundbom
BACKGROUND: Bariatric procedures are increasingly being used, but data on bowel habits are scarce. OBJECTIVES: To assess changes in gastrointestinal function and patient-scored symptoms after Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion with duodenal switch (BPD/DS). SETTING: University hospital in Sweden. METHODS: We recruited 268 adult patients (mean age of 42.5 yr, body mass index 44.8, 67.9% female) listed for RYGB and BPD/DS...
September 28, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29103706/alterations-in-ruminal-bacterial-populations-at-induction-and-recovery-from-diet-induced-milk-fat-depression-in-dairy-cows
#13
D W Pitta, N Indugu, B Vecchiarelli, D E Rico, K J Harvatine
Ten ruminally cannulated Holstein cows were used in a crossover design that investigated changes in ruminal bacterial populations in response to induction and recovery from diet-induced milk fat depression (MFD). Further, the effect on the ruminal microbiota of the cows with diet-induced milk fat depression inoculated with rumen contents from non-milk fat-depressed donor cows was evaluated. Milk fat depression was induced during the first 10 d of each period by feeding a low-fiber, high-starch, and high-polyunsaturated fatty acid diet (26...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29092483/a-switchable-positive-and-negative-air-pressure-device-for-efficient-and-gentle-handling-of-nanofiber-scaffolds
#14
Nathan A Hotaling, Vladimir Khristov, Arvydas Maminishkis, Kapil Bharti, Carl G Simon
A scaffold handling device (SHD) has been designed that can switch from gentle suction to positive pressure to lift and place nanofiber scaffolds. In tissue engineering laboratories, delicate fibrous scaffolds, such as electrospun nanofiber scaffolds, are often used as substrates for cell culture. Typical scaffold handling procedures include lifting the scaffolds, moving them from one container to another, sterilization, and loading scaffolds into cell culture plates. Using tweezers to handle the scaffolds can be slow, can damage the scaffolds, and can cause them to wrinkle or fold...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29078612/teaching-uniportal-video-assisted-thoracic-surgery-in-rome
#15
Elisa Meacci, Dania Nachira, Maria Teresa Congedo, Stefano Margaritora
Uniportal video-assisted thoracic surgery (VATS) has recently gained popularity as procedure for major lung resections, and actually seems to be the future of thoracic surgery. Uniportal VATS has shown to be feasible and safe as thoracotomy when a correct and appropriate learning curve is done. However, switching from open or triportal VATS to uniportal VATS approach requires a proper training and a consequent learning curve even among experienced thoracoscopic surgeons.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29056109/respiratory-syncytial-virus-infection-control-challenges-with-a-novel-polymerase-chain-reaction-assay-in-a-tertiary-medical-center
#16
Parham Sendi, Adrian Egli, Marc Dangel, Reno Frei, Sarah Tschudin-Sutter, Andreas F Widmer
OBJECTIVES To evaluate host characteristics, mode of infection acquisition, and infection control procedures in patients with a positive respiratory syncytial virus (RSV) test result after the introduction of the GenXpert Influenza/RSV polymerase chain reaction (PCR) assay. DESIGN Retrospective cohort study. PATIENTS Adults with a positive PCR test result for RSV who were hospitalized in a tertiary academic medical center between January 2015 and December 2016 were included in this study. Our infection control policy applies contact isolation precautions only for immunocompromised patients...
October 23, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29053202/treatment-satisfaction-with-itca-650-a-novel-drug-device-delivering-continuous-exenatide-versus-twice-daily-injections-of-exenatide-in-type-2-diabetics-on-metformin
#17
Robert Henry, Julio Rosenstock, John F McCarthy, Ginger Carls, Tom Alessi, John Yee, Michelle Baron
AIMS: To evaluate treatment satisfaction in patients with type 2 diabetes (T2D), not adequately controlled by metformin, randomized to ITCA 650 (continuous exenatide in osmotic mini-pump) versus twice-daily exenatide injections (Ex-BID). MATERIALS AND METHODS: The Diabetes Medication Satisfaction Tool (DM-SAT) was administered and assessments made at baseline, week 8, and week 20 in a 24 week open-label phase 2 trial. In Stage I (weeks 1-12), 155 patients, comprising the ITT population, were randomized to three groups: ITCA 650 20 μg/day, ITCA 650 40 μg/day and Ex-BID 10 μg BID...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29047049/comparison-of-imaging-modalities-for-detecting-complications-in-bariatric-surgery
#18
Sergio Susmallian, Eduard Folb, Royi Barnea, Asnat Raziel
PURPOSE: The purpose of this study is to evaluate the results of routine fluoroscopic swallowing study (FSS) imaging 24 h after surgery and computed tomography (CT) on demand based on clinical data, in diagnosing complications after bariatric surgery. MATERIAL AND METHODS: This retrospective study includes 9386 patients that underwent bariatric surgery. A total of 3241 (34.53%) patients underwent FSS imaging following the surgical procedure, and 106 (1.13%) patients underwent CT...
October 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29045310/risk-of-stroke-after-transcatheter-prosthetic-aortic-valve-implant-with-aortic-bioprosthesis-subclinical-thrombosis-and-possible-therapeutic-implications
#19
Giuseppe Di Pasquale, Gloria V Coutsoumbas, Silvia Zagnoni
: Many factors could increase the risk of stroke after transcatheter prosthetic aortic valve implant, mainly related to the procedure itself, or to the type of valvular prosthesis, or to the presence of atrial fibrillation. There is a wide variability in the antithrombotic treatment utilized in clinical practice, as far as the choice of drugs (anticoagulant, single or dual antiplatelet treatment), and its optimal duration. The most popular therapeutic strategy, also recommended by the Scientific Societies, is dual antiplatelet (aspirin and clopidogrel) for the first 3-6 months then switching to single antiplatelet (usually aspirin), limiting oral anticoagulant therapy only to those patients with other primary indication to the treatment...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29039000/transcriptional-and-posttranscriptional-regulation-of-drought-stress-treatments-in-brachypodium-leaves
#20
Edoardo Bertolini, Mario Enrico Pè, Erica Mica
Plant sensing drought stress conditions activate complex molecular networks leading to a rapid reprogramming of plant physiology and metabolism, in order to survive in suboptimal conditions.Here, we describe a standardized in vivo soil drought assay to investigate the effects of drought stress on leaf growth. Since it is now clear that stress responses can be specific to developmental stages and cell types, we describe a procedure to dissect the leaf in three distinct areas in order to study transcriptional and posttranscriptional gene regulation on both organ and cellular levels...
2018: Methods in Molecular Biology
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