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https://www.readbyqxmd.com/read/29786456/what-everybody-should-know-about-postural-changes
#1
Benoit Dugué, Giovanni Lombardi, Giuseppe Banfi
Posture changes have been known for a long time to influence the concentration of many analytes in blood especially macromolecules. It is very clear that when someone switches from supine to sitting or standing or from sitting to standing a hemoconcentration is induced. Similarly, when someone switches from standing to sitting or lying a hemodilution occurs. In the context of clinical chemistry, rules have been issued to buffer the impact of postural changes close to the blood specimen collection (e.g. 15 min of seated rest before the blood puncture)...
May 22, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29778598/relevance-of-antiplatelet-therapy-duration-after-stent-assisted-coil-embolization-for-unruptured-intracranial-aneurysms
#2
Tackeun Kim, Chang Hyeun Kim, Si-Hyuck Kang, Seung Pil Ban, O-Ki Kwon
BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) for preventing delayed thromboembolic events (DTEs) remains unclear. We aimed to determine whether longer DAPT provides improved protection against delayed DTEs. METHODS: This retrospective cohort study included 507 stent-assisted coil embolization procedures using a single stent for unruptured intracranial aneurysms. We performed coarsened exact matching according to the duration of maintenance DAPT...
May 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29774520/implantation-of-bioresorbable-scaffolds-under-guidance-of-optical-coherence-tomography-feasibility-and-pilot-clinical-results-of-a-systematic-protocol
#3
Juan Luis Gutiérrez-Chico, Carlos Cortés, Michele Schincariol, Ula Limon, Meric Yalcinli, María-Alexandra Durán-Cortés, Milosz Jaguszewski
BACKGROUND: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. METHODS: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly...
May 18, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29768084/effect-of-phototherapy-on-masseter-and-anterior-temporal-muscles-before-induction-of-fatigue-a-randomized-sham-controlled-blind-clinical-trial
#4
Camila Haddad Leal de Godoy, Lara Jansiski Motta, Washington Steagall Júnior, Marcela Leticia Leal Gonçalves, Daniela Fátima Teixeira da Silva, Raquel Agnelli Mesquita-Ferrari, Aldo Brugnera Júnior, Sandra Kalil Bussadori
OBJECTIVE: This is a randomized, sham-controlled, blind clinical trial that aimed to evaluate the effect of phototherapy on bite force, mandibular range of motion, sensitivity to palpation, and fatigue in the masseter and anterior temporal muscles of young patients when administered before the induction of fatigue. MATERIALS AND METHODS: Fifty-two healthy volunteers aged 18-23 years were randomly allocated to a laser group and sham group. Both groups were submitted to a clinical evaluation to record mandibular range of motion, bite force, muscle sensitivity to palpation, and muscle fatigue...
May 16, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29764847/a-mysterious-postoperative-rash
#5
Maria Chicco, George Filobbos, Nicholas Francis, Paul Ziprin
This case report describes the development of a rash in a patient admitted with large bowel obstruction secondary to carcinoma of the sigmoid colon. The patient underwent a Hartmann's procedure and right hemicolectomy for a metastatic deposit at the terminal ileum. On postoperative day 3, the patient developed a bullous haemorrhagic rash on the thighs, flanks and abdomen, associated with a sharp drop in platelet count. Suspicion of heparin-induced skin necrosis was raised, and prophylactic enoxaparin was switched to fondaparinux...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29760561/an-efficient-system-for-gene-perturbation-in-embryonic-hippocampal-progenitors-using-ex-vivo-electroporation-followed-by-in-vitro-dissociated-cell-culture
#6
Bhavana Muralidharan, Leora D'Souza, Shubha Tole
We established an efficient cell culture assay that permits combinatorial genetic perturbations in hippocampal progenitors to examine cell-autonomous mechanisms of fate specification. The procedure begins with ex vivo electroporation of isolated, intact embryonic brains, in a manner similar to in utero electroporation but with greatly improved access and targeting. The electroporated region is then dissected and transiently maintained in organotypic explant culture, followed by dissociation and plating of cells on coverslips for in vitro culture...
2018: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/29749607/increasing-antipsychotic-dose-versus-switching-antipsychotic-for-non-response-in-schizophrenia
#7
REVIEW
Myrto T Samara, Elisabeth Klupp, Bartosz Helfer, Philipp H Rothe, Johannes Schneider-Thoma, Stefan Leucht
BACKGROUND: Many people with schizophrenia do not respond to an initially prescribed antipsychotic drug. In such cases, one treatment strategy could be to increase the antipsychotic dose; and another strategy could be to switch to a different antipsychotic drug. OBJECTIVES: To examine the efficacy of increasing the antipsychotic dose versus switching the antipsychotic drug in the treatment of non-responsive people with schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group Trials Register (10 June 2014, 6 October 2015, and 30 March 2017)...
May 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29748700/myocardial-stress-perfusion-mri-experience-in-pediatric-and-young-adult-patients-following-arterial-switch-operation-utilizing-regadenoson
#8
Cory V Noel, Ramkumar Krishnamurthy, Prakash Masand, Brady Moffett, Tobiash Schlingmann, Benjamin Y Cheong, Rajesh Krishnamurthy
Dextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardial perfusion assessment within ASO patients. There is no report on the utility of regadenoson as a stress agent in children following ASO. Our objective was to observe the safety and feasibility of regadenoson as a pharmacologic stressor for perfusion cardiac MR in a pilot cohort of pediatric and young-adult patients who have undergone ASO...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29744984/pd-titanium-relay-catalysis-enables-switch-of-alkoxide-%C3%AF-allyl-to-dienolate-reactivity-for-spiro-heterocycle-synthesis
#9
Yu Zhao, Li-Cheng Yang, Zher Yin Tan, Zi-Qiang Rong, Ruoyang Liu, Ya-Nong Wang
We report herein divergent syntheses of [5,5] and [6,5] spiro-heterocycles under Lewis acid-assisted palladium catalysis. In particular, an unprecedented switch of alkoxide-π-allyl to dienolate reactivity was achieved by the use of palladium-titanium relay catalysis, which represents an umpolung reactivity of vinylethylene carbonates. This catalytic method uses a simple procedure with commercially available catalysts, and delivers both classes of spiro-heterocycles bearing three continuous stereocenters in high yield and uniformly excellent diastereoselectivity...
May 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29744808/systematic-review-of-operative-outcomes-of-robotic-surgical-procedures-performed-with-endoscopic-linear-staplers-or-robotic-staplers
#10
REVIEW
Mario Gutierrez, Richard Ditto, Sanjoy Roy
A comprehensive review of operative outcomes of robotic surgical procedures performed with the da Vinci robotic system using either endoscopic linear staplers (ELS) or robotic staplers is not available in the published literature. We conducted a literature search to identify publications of robotic surgical procedures in all specialties performed with either ELS or robotic staplers. Twenty-nine manuscripts and six abstracts with relevant information on operative outcomes published from January 2011 to September 2017 were identified...
May 9, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29742135/domestication-affects-exploratory-behaviour-of-pikeperch-sander-lucioperca-l-during-the-transition-to-pelleted-food
#11
Tamás Molnár, Adrienn Csuvár, Ildikó Benedek, Marcell Molnár, Péter Kabai
Genetic selection for body size during domestication of animal species can inadvertently affect a number of physiological and behavioural traits. The pace-of-life syndrome (POLS) hypothesis predicts that domestication in an artificial environment lacking predators and providing abundant resources prefers proactive individuals with strong feeding motivation, high levels of aggression and risk taking, with low hypothalamus-pituitary-adrenal (HPA) axis responsiveness. In the present experiment we weaned fingerling pike-perch from live feed and habituated them to formulated feed...
2018: PloS One
https://www.readbyqxmd.com/read/29737155/phospholipid-tailored-titanium-carbide-nanosheets-as-a-novel-fluorescent-nanoprobe-for-activity-assay-and-imaging-of-phospholipase-d
#12
Xiaohua Zhu, Lin Fan, Shigong Wang, Chunyang Lei, Yan Huang, Zhou Nie, Shouzhuo Yao
As one of emerging inorganic graphene analogues, two-dimensional titanium carbide (Ti3C2) nanosheets have attracted extensive attention in recent years due to their remarkably structural and electronic properties. Herein, a sensitive and selective nanoprobe for fluorescent probing the phospholipase D activity was developed based on ultrathin Ti3C2 nanosheets-mediated fluorescence quenching effect. Ultrathin Ti3C2 nanosheets with ~1.3 nm in thickness were synthesized from bulk Ti3AlC2 powder by a two-step exfoliation procedure, and further modified by natural phospholipid that doped with rhodamine B-labeled phospholipid (RhB-PL-Ti3C2)...
May 8, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29734072/a-dilute-and-shoot-multispectral-integration-approach-towards-nontargeted-component-profiling-of-traditional-herbal-yin-zhi-huang-using-liquid-chromatography-photodiode-array-ion-trap-time-of-flight-characterization
#13
Meiling Wang, Yu Liu, Bin Guo, Lijuan Wei, Hao Teng, Xiaoqing Chen, Ming Ma
Ying-zhi-huang Injection (YZH-I) is a classic intravenous formulation of polyherbal Chinese medicine which has been prescribed to treat severe jaundice and acute hepatitis for nearly 50 years. Despite some published data on its major components in the constituent herbs, the overall chemical profile of the potentially bioactive ingredients in YZH-I formula remains largely unknown. Here we developed a multispectral integration approach towards nontargeted phytochemical profiling of YZH-I by liquid chromatography-ultraviolet diode array detector coupled to ion trap/time-of-flight multistage mass spectrometry (LC-DAD-IT(MSn )/TOF) with fast polarity-switching mode...
April 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29728885/gadopentatic-acid-affects-in-vitro-proliferation-and-doxorubicin-response-in-human-breast-adenocarcinoma-cells
#14
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
Contrasting agents (CAs) that are administered to patients during magnetic resonance imaging to facilitate tumor identification are generally considered harmless. However, gadolinium (Gd) based contrast agents can be retained in the body, inflicting specific cell line cytotoxicity. We investigate the effect of Gadopentatic acid (Gd-DTPA) on human breast adenocarcinoma MCF-7 cells. These cells exhibit a toggle switch response: exposure to 0.1 and 1 mM concentrations of Gd-DTPA enhances proliferation, which is hindered at a higher 10 mM concentration...
May 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29727561/ethane-bridged-bis-porphyrin-conformational-changes-as-an-effective-analytical-tool-for-non-enzymatic-detection-of-urea-in-the-physiological-range
#15
Alessandro Buccolieri, Mohammed Hasan, Simona Bettini, Valentina Bonfrate, Luca Salvatore, Angelo Santino, Victor Borovkov, Gabriele Giancane
Conformational switching induced on ethane-bridged bis-porphyrins was used as a sensitive transduction method for revealing the presence of urea dissolved in water via non-enzymatic approach. Bis-porphyrins were deposited on solid quartz slides by means of the spin-coating method. Molecular conformations of Zn and Ni mono-metallated bis-porphyrins were influenced by water solvated urea molecules and their fluorescence emission was modulated by the urea concentration. Absorption, fluorescence and Raman spectroscopies allowed the identification of supramolecular processes which are responsible for host-guest interaction between the active layers and urea molecules...
May 4, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29724616/a-landscape-of-bariatric-surgery-in-canada-for-the-treatment-of-obesity-type-2-diabetes-and-other-comorbidities-in-adults
#16
REVIEW
Mehran Anvari, Rodrigo Lemus, Ruth Breau
Obesity has escalated worldwide and in Canada. Many chronic conditions, including type 2 diabetes, are directly correlated with obesity, and although the benefits and effectiveness of bariatric surgery have been proven in terms of sustained weight loss and improving comorbidities, the procedure is underaccessed and underutilized in Canada. We explored the complex landscape of bariatric surgery in Canada, reviewing the current state and focusing on the volume of procedures nationwide and at the provincial level, the type of surgical procedures performed, their outcomes and their associated complications...
December 12, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29718419/introducing-structure-switching-functionality-into-small-molecule-binding-aptamers-via-nuclease-directed-truncation
#17
Zongwen Wang, Haixiang Yu, Juan Canoura, Yingzhu Liu, Obtin Alkhamis, Fengfu Fu, Yi Xiao
We report a broadly applicable enzyme digestion strategy for introducing structure-switching functionality into small-molecule-binding aptamers. This procedure is based on our discovery that exonuclease III (Exo III) digestion of aptamers is greatly inhibited by target binding. As a demonstration, we perform Exo III digestion of a pre-folded three-way-junction (TWJ)-structured cocaine-binding aptamer and a stem-loop-structured ATP-binding aptamer. In the absence of target, Exo III catalyzes 3'-to-5' digestion of both aptamers to form short, single-stranded products...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29716228/reaxff-molecular-dynamics-simulation-of-intermolecular-structure-formation-in-acetic-acid-water-mixtures-at-elevated-temperatures-and-pressures
#18
Mert Y Sengul, Clive A Randall, Adri C T van Duin
The intermolecular structure formation in liquid and supercritical acetic acid-water mixtures was investigated using ReaxFF-based molecular dynamics simulations. The microscopic structures of acetic acid-water mixtures with different acetic acid mole fractions (1.0 ≥ xHAc ≥ 0.2) at ambient and critical conditions were examined. The potential energy surface associated with the dissociation of acetic acid molecules was calculated using a metadynamics procedure to optimize the dissociation energy of ReaxFF potential...
April 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29716021/software-defined-networking-control-plane-for-seamless-integration-of-multiple-silicon-photonic-switches-in-datacom-networks
#19
Yiwen Shen, Maarten H N Hattink, Payman Samadi, Qixiang Cheng, Ziyiz Hu, Alexander Gazman, Keren Bergman
Silicon photonics based switches offer an effective option for the delivery of dynamic bandwidth for future large-scale Datacom systems while maintaining scalable energy efficiency. The integration of a silicon photonics-based optical switching fabric within electronic Datacom architectures requires novel network topologies and arbitration strategies to effectively manage the active elements in the network. We present a scalable software-defined networking control plane to integrate silicon photonic based switches with conventional Ethernet or InfiniBand networks...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29707325/subxiphoid-and-subcostal-arch-three-ports-thoracoscopic-extended-thymectomy-for-myasthenia-gravis
#20
Qiang Lu, Jinbo Zhao, Juzheng Wang, Zhao Chen, Yong Han, Lijun Huang, Xiaofei Li, Yongan Zhou
Background: The approaches to thoracoscopic thymectomy in myasthenia gravis (MG) are debatable. We developed a novel approach via subxiphoid and subcostal arch, with a significantly shorter duration of operation and hospital stay, less estimated blood loss, and lower postoperative pain. Methods: From December 2012 to December 2014, 77 myasthenia gravis patients with or without thymoma underwent thoracoscopic extended thymectomy at our hospital. Among them, 41 patients were operated via the subxiphoid and subcostal arch approach and the other 36 via the conventional unilateral approach...
March 2018: Journal of Thoracic Disease
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