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https://www.readbyqxmd.com/read/29777062/brock-malignancy-risk-calculator-for-pulmonary-nodules-validation-outside-a-lung-cancer-screening-population
#1
Kaman Chung, Onno M Mets, Paul K Gerke, Colin Jacobs, Annemarie M den Harder, Ernst T Scholten, Mathias Prokop, Pim A de Jong, Bram van Ginneken, Cornelia M Schaefer-Prokop
OBJECTIVE: To assess the performance of the Brock malignancy risk model for pulmonary nodules detected in routine clinical setting. METHODS: In two academic centres in the Netherlands, we established a list of patients aged ≥40 years who received a chest CT scan between 2004 and 2012, resulting in 16 850 and 23 454 eligible subjects. Subsequent diagnosis of lung cancer until the end of 2014 was established through linking with the National Cancer Registry...
May 18, 2018: Thorax
https://www.readbyqxmd.com/read/29774177/the-new-direct-antiviral-agents-and-hepatitis-c-in-thoracic-transplantation-impact-on-donors-and-recipients
#2
REVIEW
Robert L Gottlieb, Shelley A Hall
Purpose of Review: The landscape of abdominal organ transplantation has been altered by the emergence of curative direct-acting antiviral agents for hepatitis C. Expansion of the thoracic donor pool to include the hearts and the lungs from hepatitis C-positive donors holds promise to increase available donor organs. Recent Findings: Case reports have documented separate lung and heart transplant patients who acquired, and then were cured of, donor-derived hepatitis C using these newer, more effective therapies...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29772358/tumor-to-lesion-metastasis-a-case-report-of-carcinoma-metastasis-to-multiple-sclerosis-lesion
#3
Jian-Qiang Lu, Suresh Menon, Crystal Fong, Boleslaw Lach, Christopher Power
BACKGROUND: The term of "tumor-to-lesion metastasis" is an extension of "tumor-to-tumor metastasis", which is a rare but well-documented phenomenon. Tumor metastasis to the meninges and/or central nervous system (CNS) is rare in patents with multiple sclerosis (MS), although MS lesions bear many similarities to the primary tumor microenvironment and the metastatic niche. We present the first case of malignant tumor metastasis to MS lesions with immunophenotyping of inflammatory cells in the metastatic foci...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771709/combined-recirculatory-compartmental-population-pharmacokinetic-modeling-of-arterial-and-venous-plasma-s-and-r-ketamine-concentrations
#4
Thomas K Henthorn, Michael J Avram, Albert Dahan, Lars L Gustafsson, Jan Persson, Tom C Krejcie, Erik Olofsen
BACKGROUND: The pharmacokinetics of infused drugs have been modeled without regard for recirculatory or mixing kinetics. We used a unique ketamine dataset with simultaneous arterial and venous blood sampling, during and after separate S(+) and R(-) ketamine infusions, to develop a simplified recirculatory model of arterial and venous plasma drug concentrations. METHODS: S(+) or R(-) ketamine was infused over 30 min on two occasions to 10 healthy male volunteers...
May 16, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29771243/breath-volatile-organic-compounds-of-lung-transplant-recipients-with-and-without-chronic-lung-allograft-dysfunction
#5
Lucas Küppers, Olaf Holz, Sven Schuchardt, Jens Gottlieb, Jan Fuge, Mark Greer, Jens Hohlfeld
Chronic lung allograft dysfunction (CLAD) with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS...
May 17, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29764484/selection-of-candidates-for-surgery-as-local-therapy-among-early-stage-small-cell-lung-cancer-patients-a-population-based-analysis
#6
Kaiqi Jin, Kaixuan Zhang, Feng Zhou, Jie Dai, Peng Zhang, Gening Jiang
BACKGROUND: Surgery and radiotherapy are considered local therapies for small cell lung cancer (SCLC). The present study aimed to select candidates for surgery as local therapy among patients with stage I or II SCLC, based on the eighth edition of the TNM classification for lung cancer. METHODS: Patients diagnosed with SCLC between 2004 and 2013 were selected from the Surveillance, Epidemiology, And End Results database. The TNM stage of SCLC in these patients was re-classified according to the eighth edition of the TNM classification for lung cancer...
March 31, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764370/-tuberculosis-in-advanced-hiv-infection-is-associated-with-increased-expression-of-ifn%C3%AE-and-its-downstream-targets
#7
Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J Ellner, Yukari C Manabe, Padmini Salgame
BACKGROUND: Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from latent infection. Our study was designed to assess if gene expression signatures and cytokine levels would distinguish active TB in advanced HIV. METHODS: We conducted a case-control study of whole blood RNA-Seq and plasma cytokine/chemokine analysis in HIV-infected with CD4+ T cell count of ≤ 100 cells/μl, with and without active TB...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29761043/differential-expression-patterns-of-housekeeping-genes-increase-diagnostic-and-prognostic-value-in-lung-cancer
#8
Yu-Chun Chang, Yan Ding, Lingsheng Dong, Lang-Jing Zhu, Roderick V Jensen, Li-Li Hsiao
Background: Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these "housekeeping genes" (HKGs) could separate one normal human tissue type from another. Current focus on identifying "specific disease markers" is problematic as single gene expression in a given sample represents the specific cellular states of the sample at the time of collection. In this study, we examine the diagnostic and prognostic potential of the variable expressions of HKGs in lung cancers...
2018: PeerJ
https://www.readbyqxmd.com/read/29758181/development-and-validation-of-web-based-nomograms-to-precisely-predict-conditional-risk-of-site-specific-recurrence-for-patients-with-completely-resected-non-small-cell-lung-cancer-a-multi-institutional-study
#9
Yang Zhang, Difan Zheng, Juntao Xie, Yuan Li, Yiyang Wang, Chenguang Li, Jiaqing Xiang, Yawei Zhang, Hong Hu, Yihua Sun, Haiquan Chen
BACKGROUND: There is currently no consensus regarding the optimal postoperative follow-up strategy for completely resected non-small cell lung cancer (NSCLC) patients. We aimed to develop web-based nomograms to precisely predict site-specific postoperative recurrence of NSCLC patients and to guide individual surveillance strategies including when to follow-up and what diagnostic tests to perform. METHODS: We investigated the pattern of recurrence in a series of 2017 NSCLC (squamous cell carcinoma and non-lepidic invasive adenocarcinoma) patients who underwent complete surgical resection in Fudan University Shanghai Cancer Center (development cohort), and developed web-based clinicopathologic prediction models for conditional risk of site-specific recurrence based on Cox regression...
May 11, 2018: Chest
https://www.readbyqxmd.com/read/29755636/microfluidic-chip-for-non-invasive-analysis-of-tumor-cells-interaction-with-anti-cancer-drug-doxorubicin-by-afm-and-raman-spectroscopy
#10
Han Zhang, Lifu Xiao, Qifei Li, Xiaojun Qi, Anhong Zhou
Raman spectroscopy has been playing an increasingly significant role for cell classification. Here, we introduce a novel microfluidic chip for non-invasive Raman cell natural fingerprint collection. Traditional Raman spectroscopy measurement of the cells grown in a Polydimethylsiloxane (PDMS) based microfluidic device suffers from the background noise from the substrate materials of PDMS when intended to apply as an in vitro cell assay. To overcome this disadvantage, the current device is designed with a middle layer of PDMS layer sandwiched by two MgF2 slides which minimize the PDMS background signal in Raman measurement...
March 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29755467/silicosis-and-silica-induced-autoimmunity-in-the-diversity-outbred-mouse
#11
Jessica M Mayeux, Gabriela M Escalante, Joseph M Christy, Rahul D Pawar, Dwight H Kono, Kenneth M Pollard
Epidemiological studies have confidently linked occupational crystalline silica exposure to autoimmunity, but pathogenic mechanisms and role of genetic predisposition remain poorly defined. Although studies of single inbred strains have yielded insights, understanding the relationships between lung pathology, silica-induced autoimmunity, and genetic predisposition will require examination of a broad spectrum of responses and susceptibilities. We defined the characteristics of silicosis and autoimmunity and their relationships using the genetically heterogeneous diversity outbred (DO) mouse population and determined the suitability of this model for investigating silica-induced autoimmunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755360/healthy-lung-vessel-morphology-derived-from-thoracic-computed-tomography
#12
Michael Pienn, Caroline Burgard, Christian Payer, Alexander Avian, Martin Urschler, Rudolf Stollberger, Andrea Olschewski, Horst Olschewski, Thorsten Johnson, Felix G Meinel, Zoltán Bálint
Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only very few subjects. In order to determine morphologic readouts from a large number of healthy subjects, computed tomography pulmonary angiography (CTPA) datasets, negative for pulmonary embolism, and other thoracic pathologies, were analyzed using a fully-automatic, in-house developed artery/vein separation algorithm...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29755067/-prognostic-significance-of-mode-of-nodal-involvement-in-pulmonary-pn1-squamous-cell-carcinoma
#13
Motoaki Yasukawa, Takeshi Kawaguchi, Norikazu Kawai, Takashi Tojo, Shigeki Taniguchi
According to the tumor, node, metastasis (TNM) classification of the Union for International Cancer Control (UICC) and the International Association for the Study of Lung Cancer (IASLC), N factor is defined by the anatomic extent of the metastatic lymph nodes, but is not related to the metastatic pattern. N1 is defined as "metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension". Lymph node involvement is one of the most important prognosistic factors in non-small cell lung cancer patients...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753578/racial-ethnic-disparities-in-end-of-life-care-quality-among-lung-cancer-patients-a-seer-medicare-based-study
#14
Siddharth Karanth, Suja S Rajan, Gulshan Sharma, Jose-Miguel Yamal, Robert O Morgan
INTRODUCTION: Cancer end-of-life care and associated racial-ethnic disparities have been in focus during the last few years due to concerns regarding subjective care variations and poor quality of care. Given the high mortality rate and disease burden of lung cancer, end-of-life care quality is particularly crucial for this disease. This study uses previously validated measures and examines racial-ethnic disparities in lung cancer end-of-life care quality. METHODS: This study involves retrospective analysis of patients ≥66 years, who were diagnosed with stage I-IV lung cancer, and who died on or before December 31, 2013, using the Surveillance Epidemiology and End Result-Medicare data from 1991-2013...
May 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29753211/lc-ms-ms-method-for-determination-of-cyclin-dependent-kinase-inhibitors-bp-14-and-bp-20-and-its-application-in-pharmacokinetic-study-in-rat
#15
Jitka Široká, Martina Čečková, Lubor Urbánek, Vladimír Kryštof, Tomáš Gucký, Jakub Hofman, Miroslav Strnad, František Štaud
N2 -(4-Amino-cyclohexyl)-9-cyclopentyl-N6 -(6-furan-2-yl-pyridine-3-ylmethyl)-9H-purine-2,6-diamine (BP-14) and 2-(5-{[2-(4-amino-cyclohexylamino)-9-cyclopentyl-9H-purine-6-ylamino]-methyl}-pyridine-2-yl)-phenol (BP-20) are novel cyclin-dependent kinase inhibitors, structurally related to roscovitine, with significant biological activity. A simple, selective and sensitive liquid chromatography - tandem mass spectrometry method for determining them in rat plasma, using roscovitine as an internal standard, was developed and validated...
May 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29753166/double-determination-of-long-noncoding-rnas-from-lung-cancer-via-multi-amplified-electrochemical-genosensor-at-sub-femtomole-level
#16
Xiaoyan Li, Gang Peng, Feng Cui, Qianying Qiu, Xiaojun Chen, He Huang
An ultrasensitive electrochemical genosensor has been fabricated for the double determination of two different specific sequences deduced from the maternally expressed gene3 (MEG3) lncRNA (long noncoding RNA), which was demonstrated by coupling RNase A-aided target recycling with DNA supersandwich-induced signal enhancement, based on a composite interface of graphene-like tungsten disulfide/dendritic gold nanostructures (WS2 /DGN). Firstly, duple target sequences of T1 and T2 were captured by the primer probes of P1 /P2 functionalized Fe3 O4 @C magnetic nanoparticles, via the DNA/RNA hybridization between T1 /T2 and P1 /P2 ...
May 2, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29749011/rapid-lc-ms-ms-method-for-quantification-of-vinorelbine-and-4-o-deacetylvinorelbine-in-human-whole-blood-suitable-to-monitoring-oral-metronomic-anticancer-therapy
#17
Giuseppe Corona, Milena Gusella, Anna Gaspardo, Gianmaria Miolo, Laura Bertolaso, Elisa Pezzolo, Felice Pasini, Agostino Steffan, Donatella Caruso
A rapid and sensitive LC-MS/MS method for therapeutic drug monitoring oral vinorelbine (VRL) metronomic anticancer chemotherapy has been developed and validated. Analysis of VRL and its main active metabolite 4-O-deacetylvinorelbine (M1) was performed in whole blood matrix. Both analytes were extracted by protein precipitation and separated on an Onyx monolith C18, 50 x 2 mm column then quantified by positive electrospray ionization and multiple reaction monitoring mode. The LLOQ was 0.05 ng/mL for both VRL and M1...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29748020/validation-of-the-8th-tnm-classification-for-small-cell-lung-cancer-in-a-retrospective-material-from-sweden
#18
Salomon Tendler, Vitali Grozman, Rolf Lewensohn, Georgios Tsakonas, Kristina Viktorsson, Luigi De Petris
BACKGROUND: The purpose of this study was to evaluate on a Swedish cohort of small cell lung cancer (SCLC) patients whether the 8th TNM staging system can provide additional prognostic information in comparison with the previous 6th and 7th TNM versions and the older 2-stage LD vs ED system. METHODS: We reviewed the medical records of patients (pts) with SCLC diagnosed between January 2008 and February 2016 in the Stockholm and Gotland region. Each patient file was revised and reclassified from the VASGL system to the 6th , 7th and 8th TNM system respectively...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29747538/protective-effect-of-standardized-extract-of-myrtus-communis-l-myrtle-on-experimentally-bleomycin-induced-pulmonary-fibrosis-biochemical-and-histopathological-study
#19
Mitra Samareh Fekri, Ali Mandegary, Fariba Sharififar, Hamid Reza Poursalehi, Mohammad Hadi Nematollahi, Atefe Izadi, Mohammad Mehdipour, Amir Asadi, Masoomeh Samareh Fekri
CONTEXT: Myrtle (Myrtus communis L) has been used widely in traditional medicine for different respiratory disorders. Idiopathic pulmonary fibrosis (IPF) is an inflammatory disease characterized by progressive loss of lung function with poor prognosis. The pathogenesis of disease has not been completely elucidated, but probably persistent epithelial damages are involved. OBJECTIVE: Evaluation of biochemical and histopathological effect of preventive and therapeutic doses of myrtle against bleomycin (BLM)-induced pulmonary fibrosis (PF) in animal model...
May 11, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29743185/lung-cancer-mortality-and-exposure-to-synthetic-metalworking-fluid-and-biocides-controlling-for-the-healthy-worker-survivor-effect
#20
Erika Garcia, Sally Picciotto, Andreas M Neophytou, Patrick T Bradshaw, John R Balmes, Ellen A Eisen
OBJECTIVES: Synthetic metalworking fluids (MWFs), widely used to cool and lubricate industrial machining and grinding operations, have been linked with increased risk of several cancers. Estimates of their relation with lung cancer, however, are inconsistent. Controlling for the healthy worker survivor effect, we examined the relations between lung cancer mortality and exposure to synthetic MWF, as well as to biocides added to water-based fluids to control microbial growth, in a cohort of autoworkers...
May 9, 2018: Occupational and Environmental Medicine
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