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Light emitting diodes skin

Igor S Sidorov, Roman V Romashko, Vasily T Koval, Rashid Giniatullin, Alexei A Kamshilin
We recently pointed out the important role of dermis deformation by pulsating arterial pressure in the formation of a photoplethysmographic signal at green light. The aim of this study was to explore the role of this novel finding in near-infrared (NIR) light. A light-emitting diode (LED)-based imaging photoplethysmography (IPPG) system was used to detect spatial distribution of blood pulsations under frame-to-frame switching green and NIR illumination in the palms of 34 healthy individuals. We observed a significant increase of light-intensity modulation at the heartbeat frequency for both illuminating wavelengths after a palm was contacted with a glass plate...
2016: PloS One
Balakrishnan Nirmal
Management of periungual wart is a great challenge, especially when there is subungual extension. The major cause of recurrence of wart is improper clinical assessment of its extent and not directing therapy against the entire wart. This difficulty of ascertaining its extent could be overcome with this finger-shaped red light emitting diode device. Red light in the device penetrates the thick palmar skin and dark constitutive skin colour due to its longer wavelength.
July 2016: Journal of Cutaneous and Aesthetic Surgery
Nikolai Blanik, Konrad Heimann, Carina Pereira, Michael Paul, Vladimir Blazek, Boudewijn Venema, Thorsten Orlikowsky, Steffen Leonhardt
Vital parameter monitoring of term and preterm infants during incubator care with self-adhesive electrodes or sensors directly positioned on the skin [e.g. photoplethysmography (PPG) for oxygen saturation or electrocardiography (ECG)] is an essential part of daily routine care in neonatal intensive care units. For various reasons, this kind of monitoring contains a lot of stress for the infants. Therefore, there is a need to measure vital parameters (for instance respiration, temperature, pulse, oxygen saturation) without mechanical or conductive contact...
October 15, 2016: Biomedizinische Technik. Biomedical Engineering
Ming Dai, Xueliang Xiao, Xin Chen, Haoming Lin, Wanqing Wu, Siping Chen
With the increasing aging population as well as health concerns, chronic heart disease has become the focus of public attention. A comfortable, low-powered, and wearable electrocardiogram (ECG) system for continuously monitoring the elderly's ECG signals over several hours is important for preventing cardiovascular diseases. Traditional ECG monitoring apparatus is often inconvenient to carry, has many electrodes to attach to the chest, and has a high-power consumption. There is also a challenge to design an electrocardiograph that satisfies requirements such as comfort, confinement, and compactness...
October 14, 2016: Australasian Physical & Engineering Sciences in Medicine
Chang Taek Oh, Tae-Rin Kwon, Eun Ja Choi, Soon Re Kim, Joon Seok, Seog Kyun Mun, Kwang Ho Yoo, Yeon Shik Choi, Sun Young Choi, Beom Joon Kim
BACKGROUND: Skin hyperpigmentary disorders including postinflammatory hyperpigmentation, melasma, solar lentigines, and conditions like freckles are common. The light-emitting diodes (LEDs) are the latest category of nonthermal and noninvasive phototherapy to be considered in skin pigmentation disorder treatment. PURPOSE: The purpose of this study was to investigate the effects of 660-nm LED on inhibition of melanogenesis. We investigated whether a 660-nm LED affected melanin synthesis in in vitro and in vivo models, and we explored the mechanisms involved...
October 1, 2016: Photodermatology, Photoimmunology & Photomedicine
S K Kim, H R You, S H Kim, S J Yun, S C Lee, J B Lee
BACKGROUND: Red-coloured light-emitting diodes (LEDs) can improve skin photorejuvenation and regeneration by increasing cellular metabolic activity. AIM: To evaluate the effectiveness of visible LEDs with specific wavelengths for skin photorejuvenation in vitro and in vivo. METHODS: Normal human dermal fibroblasts (HDFs) from neonatal foreskin were cultured and irradiated in vitro by LEDs at different wavelengths (410-850 nm) and doses (0-10 J/cm(2) )...
October 2016: Clinical and Experimental Dermatology
Gregor Belušič, Marko Ilić, Andrej Meglič, Primož Pirih
Optical experiments often require fast-switching light sources with adjustable bandwidths and intensities. We constructed a wavelength combiner based on a reflective planar diffraction grating and light emitting diodes with emission peaks from 350 to 630 nm that were positioned at the angles corresponding to the first diffraction order of the reversed beam. The combined output beam was launched into a fibre. The spacing between 22 equally wide spectral bands was about 15 nm. The time resolution of the pulse-width modulation drivers was 1 ms...
2016: Scientific Reports
Jeonghyun Kim, Giovanni A Salvatore, Hitoshi Araki, Antonio M Chiarelli, Zhaoqian Xie, Anthony Banks, Xing Sheng, Yuhao Liu, Jung Woo Lee, Kyung-In Jang, Seung Yun Heo, Kyoungyeon Cho, Hongying Luo, Benjamin Zimmerman, Joonhee Kim, Lingqing Yan, Xue Feng, Sheng Xu, Monica Fabiani, Gabriele Gratton, Yonggang Huang, Ungyu Paik, John A Rogers
Recent advances in materials, mechanics, and electronic device design are rapidly establishing the foundations for health monitoring technologies that have "skin-like" properties, with options in chronic (weeks) integration with the epidermis. The resulting capabilities in physiological sensing greatly exceed those possible with conventional hard electronic systems, such as those found in wrist-mounted wearables, because of the intimate skin interface. However, most examples of such emerging classes of devices require batteries and/or hard-wired connections to enable operation...
August 2016: Science Advances
Derek Ho, Ekaterina Kraeva, Ted Wun, R Rivkah Isseroff, Jared Jagdeo
BACKGROUND: Skin fibrosis is involved in a variety of pathologic conditions ranging from scar formation secondary to surgery or trauma to immune-mediated processes. Skin fibrosis is a significant international health problem with an estimated incidence of greater than 100 million people affected per year worldwide with few effective treatment options available. Preliminary in vitro data generated by our research group suggests that red light can function as a stand-alone treatment for skin fibrosis...
2016: Trials
Zhaoyang Zhong, Hyungjin Lee, Dongwoo Kang, Sin Kwon, Young-Man Choi, Inhyuk Kim, Kwang-Young Kim, Youngu Lee, Kyoohee Woo, Jooho Moon
Simple, low-cost and scalable patterning methods for Cu nanowire (NW)-based flexible transparent conducting electrodes (FTCEs) are essential for the widespread use of Cu NW FTCEs in numerous flexible optoelectronic devices, wearable devices, and electronic skins. In this paper, continuous patterning for Cu NW FTCEs via a combination of selective intense pulsed light (IPL) and roll-to-roll (R2R) wiping process was explored. The development of continuous R2R patterning could be achieved because there was significant difference in adhesion properties between NWs and substrates depending on whether Cu NW coated area was irradiated by IPL or not...
August 23, 2016: ACS Nano
Eugènia Agut-Busquet, Jorge Romaní, Yolanda Gilaberte, Ana García-Malinis, Miquel Ribera-Pibernat, Jesús Luelmo
Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions...
August 4, 2016: Photochemical & Photobiological Sciences
Line Lundbæk Barnkob, Aikaterini Argyraki, Paul Michael Petersen, Jette Jakobsen
The dietary intake of vitamin D is currently below the recommended intake of 10-20μg vitamin D/day. Foods with increased content of vitamin D or new products with enhanced vitamin D are warranted. Light-emitting diodes (LEDs) are a potential new resource in food production lines. In the present study the exposure conditions with ultraviolet (UV) LEDs were systematically investigated in the wavelength range 280-340nm for achieving optimal vitamin D bio-fortification in pig skin. A wavelength of 296nm was found to be optimal for vitamin D3 production...
December 1, 2016: Food Chemistry
R Glen Calderhead, David B Vasily
Low level light therapy (LLLT) with light-emitting diodes (LEDs) is emerging from the mists of black magic as a solid medico-scientific modality, with a substantial buildup of corroborative bodies of evidence for its efficacy and elucidation of the modes of action. Reports are appearing from many different specialties; however, of particular interest to plastic surgeons treating the aging face is the proven action of LED-LLLT on skin cells in both the epidermis and dermis and enhanced blood flow. Thus, LED-LLLT is a safe and effective stand-alone therapy for patients who are prepared to wait until the final effect is perceived...
July 2016: Clinics in Plastic Surgery
Marcus Vinícius de Matos Gomes, Marcelo Henrique Manfredo, Leandro Vaz Toffoli, Daniellen Christine Castro-Alves, Lucas Magnoni do Nascimento, Wyllian Rafael da Silva, Roberto Kiyoshi Kashimoto, Gelson Marcos Rodrigues-Jr, Viviane Batista Estrada, Rodrigo Antonio Andraus, Gislaine Garcia Pelosi
The use of light emitting diodes (LED) as a therapeutic resource for wound healing has increased over the last years; however, little is still known about the molecular pathways associated to LED exposure. In the present study, we verified the effects of LED therapy on DNA methylation and expression of the DNA methyltransferase (Dnmt) genes, Dnmt1 and Dnmt3a, in an in vivo model of epithelial wound healing. Male Wistar rats were submitted to epithelial excision in the dorsal region and subsequently distributed within the experimental groups: group 1, animals that received irradiation of 0...
September 2016: Lasers in Medical Science
Yanhong Li, Jigang Zhang, Yanfeng Xu, Yunlin Han, Binbin Jiang, Lan Huang, Hua Zhu, Yuhuan Xu, Weiling Yang, Chuan Qin
The biological effects of different wavelengths of light emitting diode (LED) light tend to vary from each other. Research into use of photobiomodulation for treatment of skin wounds and the underlying mechanisms has been largely lacking. We explored the histopathological basis of the therapeutic effect of photobiomodulation and the relation between duration of exposure and photobiomodulation effect of different wavelengths of LED in a Japanese big-ear white rabbit skin-wound model. Skin wound model was established in 16 rabbits (three wounds per rabbit: one served as control, the other two wounds were irradiated by red and blue LED lights, respectively)...
2016: PloS One
Jee-Bum Lee, Soo Hyeon Bae, Ki Rang Moon, Eui Young Na, Sook Jung Yun, Seung-Chul Lee
BACKGROUND: Cathelicidin (LL-37), Toll-like receptor 2 (TLR 2), and kallikreins (KLKs) are key inflammatory mediators in rosacea. Laser or light-based devices have been successfully used for rosacea. OBJECTIVE: We investigated the effects of light-emitting diodes (LED) on LL-37, KLKs, TLR 2, and protease activity in cultured normal human epidermal keratinocytes(NHEKs) and rosacea-like mouse skin(RLMS). METHODS: LL-37, KLK 5, KLK 7, and vitamin D receptor were induced by 1α,25-dihydroxyvitaminD3 (VD3 ) and TLR 2 by Ad-CMV transfection in cultured NHEKs...
June 17, 2016: Experimental Dermatology
Andreas Nikolis, Steven Bernstein, Brian Kinney, Nicolo Scuderi, Shipra Rastogi, John S Sampalis
PURPOSE: Many treatment modalities exist to counteract the effects of cutaneous aging. Ablative methods have been the mainstay for nonsurgical facial rejuvenation. In recent years, nonablative techniques have been developed with the aim of achieving facial rejuvenation without epidermal damage. Light-emitting diode (LED) photorejuvenation is a novel nonablative technique that induces collagen synthesis through biophotomodulatory pathways. MATERIALS AND METHODS: A single-center, randomized, single-blinded, placebo-controlled, split-faced clinical trial was designed...
2016: Clinical, Cosmetic and Investigational Dermatology
Paulo C L Silveira, Karina B Ferreira, Franciani R da Rocha, Bruno L S Pieri, Giulia S Pedroso, Claudio T De Souza, Renata T Nesi, Ricardo A Pinho
The aim of the study was to investigate the biochemical and molecular changes in the process of epidermal healing of burn injuries after therapeutic treatment with low-power laser (LPL) and light-emitting diode (LED). Rats were divided into six groups: skin without injury (Sham), burn wounds (BWs), BW + 660-nm LPL, BW + 904-nm LPL, BW + 632-nm LED, and BW + 850-nm LED. The burn wound model was performed using a 100 °C copper plate, with 10 s of contact in the skin. The irradiations started 24 h after the lesion and were performed daily for 7 days...
August 2016: Inflammation
Andrew Mamalis, Daniel Siegel, Jared Jagdeo
Skin fibrosis, also known as skin scarring, is an important global health problem that affects an estimated 100 million persons per year worldwide. Current therapies are associated with significant side effects and even with combination therapy, progression, and recurrence is common. Our goal is to review the available published data available on light-emitting diode-generated (LED) red light phototherapy for treatment of skin fibrosis. A search of the published literature from 1 January 2000 to present on the effects of visible red light on skin fibrosis, and related pathways was performed in January 2016...
2016: Current Dermatology Reports
Andrew Mamalis, Eugene Koo, Jared Jagdeo
BACKGROUND: Light-emitting diode-generated blue light (LED-BL) is part of the visible light spectrum that does not cause DNA damage and may represent a safer alternative to ultraviolet phototherapy. Previous research demonstrated that LED-BL can inhibit adult human skin fibroblast proliferation and migration speed and is associated with increased reactive oxygen species (ROS) generation in a dose-dependent manner. In addition, resveratrol possesses potent intracellular antioxidative effects on ROS-free radicals in human skin fibroblasts...
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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