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https://www.readbyqxmd.com/read/28328623/a-novel-user-friendly-model-to-predict-corticosteroid-utilization-in-newly-diagnosed-patients-with-ulcerative-colitis
#1
Nabeel Khan, Dhruvan Patel, Yash Shah, Gary Lichtenstein, Yu-Xiao Yang
BACKGROUND: Corticosteroid (CS) use is an important marker of poor prognosis in ulcerative colitis (UC). Our aim was to develop and validate a model to predict the risk of CS utilization over the course of disease in newly diagnosed patients with UC. METHODS: Newly diagnosed patients with UC from a nationwide VA cohort were followed over time to evaluate factors predictive of CS use. Multivariate logistic regression was performed. Model development was performed in a random 2/3 of the total cohort and then validated in the remaining 1/3...
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28320292/remark-to-response-of-a-v-lichtenstein
#2
COMMENT
V N Manskikh
The arguments against the "bad luck" hypothesis suggested by C. Tomasetti and B. Vogelstein ((2015) Science, 347, 78-81) are significant in any case, and new experimental studies are necessary.
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28320291/response-to-comments-by-v-n-manskikh-do-external-or-internal-factors-lead-to-tumor-development-it-is-still-unknown
#3
COMMENT
A V Lichtenstein
The opinion is presented according to which the "bad luck" hypothesis (Tomasetti, C., and Vogelstein, B. (2015) Science, 347, 78-81), which has recently received experimental confirmation, has the right to exist, and its criticisms are largely unfounded.
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28320290/do-external-or-internal-factors-lead-to-tumor-development-it-is-still-unknown
#4
COMMENT
V N Manskikh
Arguments supporting the "bad luck" hypothesis presented by C. Tomasetti and B. Vogelstein ((2015) Science, 347, 78-81) and A. V. Lichtenstein ((2017) Biochemistry (Moscow), 82, 75-80) are critically discussed. Those arguments are not sufficient for recognition of the "bad luck" hypothesis and the leading role of internal factors in spontaneous tumor development.
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28320289/cancer-bad-luck-or-punishment
#5
REVIEW
A V Lichtenstein
Contrasting opinions on the role of extrinsic and intrinsic factors in cancer etiology (Tomasetti, C., and Vogelstein, B. (2015) Science, 347, 78-81; Wu, S., et al. (2016) Nature, 529, 43-47) variously define priorities in the war on cancer. The correlation between the lifetime risk of several types of cancer and the total number of divisions of normal self-renewing cells revealed by the authors has given them grounds to put forward the "bad luck" hypothesis. It assumes that ~70% of cancer variability is attributed to random errors arising during DNA replication in normal, noncancerous stem cells, i...
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28316769/etiological-influences-on-the-stability-of-autistic-traits-from-childhood-to-early-adulthood-evidence-from-a-twin-study
#6
Mark J Taylor, Christopher Gillberg, Paul Lichtenstein, Sebastian Lundström
BACKGROUND: Autism spectrum disorders (ASD) are persistent and lifelong conditions. Despite this, almost all twin studies focus on childhood. This twin study investigated the stability of autistic traits from childhood to early adulthood and explored the degree to which any stability could be explained by genetic or environmental factors. METHODS: Parents of over 2500 twin pairs completed questionnaires assessing autistic traits when twins were aged either 9 or 12 years and again when twins were aged 18...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28314871/-evidence-based-lichtenstein-technique
#7
W Reinpold, D Chen
Lichtenstein hernioplasty is the number one technique worldwide for open, mesh-based inguinal hernia repair. The principle of Lichtenstein hernioplasty is the tension-free reinforcement of the abdominal wall by covering the transversalis fascia and the oblique muscles with an artificial patch of mesh. The Lichtenstein technique has been modified since its inception. The technique has the benefits of low costs and a rapid learning curve and can be performed with the patient under local anesthesia. The recurrence rates after the Lichtenstein operation are significantly lower compared to open suture repair and equal to laparoendoscopic techniques...
March 17, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28294404/improved-classification-of-indeterminate-biliary-strictures-by-probe-based-confocal-laser-endomicroscopy-using-the-paris-criteria-following-biliary-stenting
#8
Pushpak Taunk, Satish Singh, David Lichtenstein, Virendra Joshi, Jason Gold, Ashish Sharma
BACKGROUND AND AIMS: Probe-based confocal laser endomicroscopy (pCLE) using the Miami Criteria has improved classification of indeterminate biliary strictures. However, previous biliary stenting may result in their misclassification as malignant strictures. Inflammatory criteria were added to form the Paris Classification to prevent this misclassification and reduce false positives. The aim of this study was to assess if the Paris Classification was more accurate than the Miami Classification in classifying indeterminate biliary strictures after biliary stenting...
March 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28290749/identification-of-eating-disorder-symptoms-in-danish-adolescents-with-the-scoff-questionnaire
#9
Mia Beck Lichtenstein, Simone Daugaard Hemmingsen, René Klinkby Støving
BACKGROUND: Eating disorders often develop in adolescence and, therefore, instruments are needed that are useful to detect risk behaviour in young people. The SCOFF is a 5-item screening instrument, named SCOFF as an acronym of keywords from the questions. It has been used widely in adult samples, but studies that evaluate the scale in adolescents are missing. AIMS: The aim of this study was to test the psychometric properties of the SCOFF in adolescents aged 11-20 years and for the first time validate the questionnaire in Danish...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28289069/omega-3-polyunsaturated-fatty-acid-fish-oil-supplementation-and-the-prevention-of-clinical-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#10
REVIEW
David S Siscovick, Thomas A Barringer, Amanda M Fretts, Jason H Y Wu, Alice H Lichtenstein, Rebecca B Costello, Penny M Kris-Etherton, Terry A Jacobson, Mary B Engler, Heather M Alger, Lawrence J Appel, Dariush Mozaffarian
Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease...
March 13, 2017: Circulation
https://www.readbyqxmd.com/read/28285575/the-power-of-timing-adding-a-time-to-completion-cutoff-to-the-word-choice-test-and-recognition-memory-test-improves-classification-accuracy
#11
Laszlo A Erdodi, Bradley T Tyson, Ayman G Shahein, Jonathan D Lichtenstein, Christopher A Abeare, Chantalle L Pelletier, Brandon G Zuccato, Brittany Kucharski, Robert M Roth
INTRODUCTION: The Recognition Memory Test (RMT) and Word Choice Test (WCT) are structurally similar, but psychometrically different. Previous research demonstrated that adding a time-to-completion cutoff improved the classification accuracy of the RMT. However, the contribution of WCT time-cutoffs to improve the detection of invalid responding has not been investigated. The present study was designed to evaluate the classification accuracy of time-to-completion on the WCT compared to the accuracy score and the RMT...
May 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28283757/concept-of-patient-specific-shape-memory-implants-for-the-treatment-of-orbital-floor-fractures
#12
Ronny Grunert, Maximilian Wagner, Christian Rotsch, Harald Essig, Susanna Posern, Friedemann Pabst, Welf-Guntram Drossel, Juergen Lichtenstein
PURPOSE: We will aim to develop implants made of a Ni-Ti shape memory alloy which can be applied for the treatment of midface fractures, such as isolated orbital floor fractures. These can then be implanted in a compressed form and unfold automatically in the body. With the help of newly developed application instruments, the implants can be applied along transnasal and transantral approaches into the maxillary sinus. Our objective is to evaluate the operation process and the functionality of these implants, already in a pre-investigation by an experienced surgeon on a phantom...
March 10, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28283256/celiac-disease-is-associated-with-childhood-psychiatric-disorders-a-population-based-study
#13
Agnieszka Butwicka, Paul Lichtenstein, Louise Frisén, Catarina Almqvist, Henrik Larsson, Jonas F Ludvigsson
OBJECTIVES: To determine the risk of future childhood psychiatric disorders in celiac disease, assess the association between previous psychiatric disorders and celiac disease in children, and investigate the risk of childhood psychiatric disorders in siblings of celiac disease probands. STUDY DESIGN: This was a nationwide registry-based matched cohort study in Sweden with 10 903 children (aged <18 years) with celiac disease and 12 710 of their siblings. We assessed the risk of childhood psychiatric disorders (any psychiatric disorder, psychotic disorder, mood disorder, anxiety disorder, eating disorder, psychoactive substance misuse, behavioral disorder, attention-deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and intellectual disability)...
March 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28273609/a-rare-case-of-a-strangulated-littre-s-hernia-with-meckel-s-diverticulum-duplication-case-report-and-literature-review
#14
C R López-Lizárraga, M P Sánchez-Muñoz, G E Juárez-López, L Pelayo-Orozco, L F De la Cerda-Trujillo, C F Ploneda-Valencia
INTRODUCTION: The Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract present in approximately 1-4% of the population; the MD duplication is exceedingly rare with only a few reports of it. Here we present the firs case of a strangulated Littre's hernia with MD duplication. PRESENTATION OF CASE: A 30-year-old male presented to the emergency room with clinical signs of small bowel obstruction, at physical examination, a right incarcerated inguinal hernia with erythema was found...
February 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28265826/intestinal-inflammation-does-not-predict-nonalcoholic-fatty-liver-disease-severity-in-inflammatory-bowel-disease-patients
#15
Rotonya M Carr, Arpan Patel, Hillary Bownik, Amanke Oranu, Caroline Kerner, Amy Praestgaard, Kimberly A Forde, K Rajender Reddy, Gary R Lichtenstein
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic steatosis in patients with inflammatory bowel disease (IBD). Both metabolic syndrome (MetS) and intestinal inflammation are implicated in NAFLD pathogenesis. METHODS: We performed a retrospective cohort study of patients with IBD and NAFLD seen in our health system from January 1997 to December 2011 to examine associations between IBD severity and phenotype; MetS; and NAFLD fibrosis as estimated by the NAFLD Fibrosis Score (NFS)...
March 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28262253/sexual-dysfunction-after-inguinal-hernia-repair-with-the-onstep-versus-lichtenstein-technique-a%C3%A2-randomized-clinical-trial
#16
Kristoffer Andresen, Jakob Burcharth, Siv Fonnes, Line Hupfeld, Josephine Philip Rothman, Søren Deigaard, Dorte Winther, Maj-Britt Errebo, Rikke Therkildsen, Dina Hauge, Fritz Søbæk Sørensen, Jesper Bjerg, Jacob Rosenberg
BACKGROUND: Sequelae after inguinal hernia repair include pain-related impairment of sexual function. Pain during intercourse can originate from the scar, scrotum, penis, or during ejaculation. The aim of this study was to investigate if the Onstep technique resulted in better results than the Lichtenstein technique regarding pain-related impairment of sexual function. METHODS: This study was part of the randomized ONLI trial (NCT01753219, Onstep versus Lichtenstein for inguinal hernia repair)...
March 2, 2017: Surgery
https://www.readbyqxmd.com/read/28258383/-new-worldwide-guidelines-for-treatment-of-inguinal-hernia-the-most-important-recommendations-from-herniasurge
#17
D Weyhe
SURGICAL TECHNIQUES: In the HerniaSurge guidelines the highest evidence is found with respect to recommendations for mesh-based surgery techniques. This includes Lichtenstein as well as the minimally invasive TEP/TAPP surgery. For discreet symptomatic or asymptomatic inguinal hernia, watchful waiting is an option if the state of health and social situation are taken into account; however, femoral hernia should be treated promptly with a mesh technique, with laparoendoscopic techniques being the more favored option...
March 3, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28257318/the-hippo-trial-a-randomized-double-blind-trial-comparing-self-gripping-parietex-progrip-mesh-and-sutured-parietex-mesh-in-lichtenstein-hernioplasty-a-long-term-follow-up-study
#18
Marijke J Molegraaf, Brechtje Grotenhuis, Bart Torensma, Victor de Ridder, Johan F Lange, Dingeman J Swank
OBJECTIVE: To evaluate the effect of a self-gripping mesh (Progrip) on the incidence of chronic postoperative inguinal pain (CPIP) and recurrence rate after Lichtenstein hernioplasty. BACKGROUND: Chronic pain is the most common complication of inguinal hernioplasty. One of the causes may be the use of sutures to secure the mesh. METHODS: Adult male patients undergoing Lichtenstein hernioplasty for a primary unilateral inguinal hernia were randomized to a self-gripping polyester mesh or a sutured polyester mesh...
March 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28255618/absent-external-oblique-musculo-aponeurotic-complex-during-inguinal-hernioplasty-a-case-report-and-review-of-literature
#19
Royson Dsouza, Nachiket Shankar, Rohin Gurubatham, Wesley Rajaleelan, Nandakumar Menon
The external oblique musculo-aponeurotic complex is an important contributor to the strength of the inguinal canal. The present case report describes the bilateral absence of the external oblique muscle in a patient. A 40-year-old male patient presented with a history of intermittent lower abdominal pain for 15 years which had increased over the past 2 years. Abdominal examination revealed bilateral reducible, incomplete, direct inguinal hernia. Elective bilateral Lichtenstein's mesh hernioplasty was planned for the patient...
March 3, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28254496/how-do-us-pediatric-residency-programs-teach-and-evaluate-community-pediatrics-and-advocacy-training
#20
Cara Lichtenstein, Benjamin D Hoffman, Rachel Y Moon
OBJECTIVE: In 2013, the Accreditation Council of Graduate Medical Education (ACGME) updated requirements for training in community pediatrics and advocacy in pediatric residency programs. In light of this update, the aim of this study was to better understand how community pediatrics is being taught and evaluated in pediatric residency programs in the US. METHODS: Cross-sectional exploratory study using a web-based survey of pediatric residency program directors in September 2014...
February 27, 2017: Academic Pediatrics
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