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https://www.readbyqxmd.com/read/28929768/protein-corona-analysis-of-silver-nanoparticles-links-to-their-cellular-effects
#1
Sabine Juling, Alicia Niedzwiecka, Linda Böhmert, Dajana Lichtenstein, Soeren Selve, Albert Braeuning, Andreas F Thünemann, Eberhard Krause, Alfonso Lampen
The breadth of applications of nanoparticles and the access to food-associated consumer products containing nano-sized materials lead to oral human exposure to such particles. In biological fluids nanoparticles dynamically interact with biomolecules and form a protein corona. Knowledge about the protein corona is of great interest for understanding the molecular effects of particles as well as their fate inside the human body. We used a mass spectrometry-based toxicoproteomics approach to elucidate mechanisms of toxicity of silver nanoparticles and to comprehensively characterize the protein corona formed around silver nanoparticles in Caco-2 human intestinal epithelial cells...
September 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28922490/risk-factors-for-football-injuries-in-young-players-aged-7-to-12-years
#2
Roland Rössler, Astrid Junge, Jiri Chomiak, Karel Němec, Jiri Dvorak, Eric Lichtenstein, Oliver Faude
OBJECTIVES: Football (soccer) is very popular amongst children. Little is known about risk factors for football injuries in children. The aim was to analyse potential injury risk factors in 7 to 12 year old players. DESIGN: Prospective epidemiological study. METHODS: We collected prospective data in Switzerland and the Czech Republic over two seasons. Coaches reported exposure of players (in hours), absence, and injury data via an internet-based registration system...
September 18, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28918629/dosimetric-quantification-of-coating-related-uptake-of-silver-nanoparticles
#3
Dajana Lichtenstein, Thomas Meyer, Linda Böhmert, Sabine Juling, Christoph Fahrenson, Soeren Selve, Andreas F Thünemann, Jan Meijer, Irina Estrela-Lopis, Albert Braeuning, Alfonso Lampen
The elucidation of mechanisms underlying cellular uptake of nanoparticles is an important topic in nanotoxicological research. Most studies dealing with silver nanoparticle uptake provide only qualitative data about internalization efficiency and do not consider nanoparticle-specific dosimetry. Therefore, we performed a comprehensive comparison of the cellular uptake of differently coated silver nanoparticles of comparable size in different human intestinal Caco-2 cell-derived models to cover also the influence of the intestinal mucus barrier and uptake-specialized M-cells...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28916338/structure-activity-relationship-study-of-small-molecule-inhibitors-of-the-deptor-mtor-interaction
#4
Jihye Lee, Yijiang Shi, Mario Vega, Yonghui Yang, Joseph Gera, Michael E Jung, Alan Lichtenstein
DEPTOR is a 48kDa protein that binds to mTOR and inhibits this kinase within mTORC1 and mTORC2 complexes. Over-expression of DEPTOR specifically occurs in the multiple myeloma (MM) tumor model and DEPTOR knockdown is cytotoxic to MM cells, suggesting it is a potential therapeutic target. Since mTORC1 paralysis protects MM cells against DEPTOR knockdown, it indicates that the protein-protein interaction between DEPTOR and mTOR is key to MM viability vs death. In a previous study, we used a yeast two-hybrid screen of a small inhibitor library to identify a compound that inhibited DEPTOR/mTOR binding in yeast...
September 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28916145/accept-or-decline-deciding-factors-in-a-voluntary-hiv-testing-program-for-probationers-and-parolees
#5
John E Denton, Bronwen Lichtenstein
No abstract text is available yet for this article.
August 30, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28903959/effect-of-prior-meal-macronutrient-composition-on-postprandial-glycemic-responses-and-glycemic-index-and-glycemic-load-value-determinations
#6
Huicui Meng, Nirupa R Matthan, Lynne M Ausman, Alice H Lichtenstein
Background: The potential impact of prior meal composition on the postprandial glycemic response and glycemic index (GI) and glycemic load (GL) value determinations remains unclear.Objective: We determined the effect of meals that varied in macronutrient composition on the glycemic response and determination of GI and GL values of a subsequent standard test food.Design: Twenty healthy participants underwent 6 test sessions within 12 wk. The subjects received each of 3 isocaloric breakfast meals (i.e., high carbohydrate, high fat, or high protein) on separate days in a random order, which was followed by a standard set of challenges (i...
September 13, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28903564/impact-of-an-artificial-digestion-procedure-on-aluminum-containing-nanomaterials
#7
Holger Sieg, Claudia Kästner, Benjamin Christoph Krause, Thomas Meyer, Agnes Burel, Linda Böhmert, Dajana Lichtenstein, Harald Jungnickel, Jutta Tentschert, Peter Laux, Albert Braeuning, Irina Estrela-Lopis, Fabienne Gauffre, Valerie Fessard, Jan Meijer, Andreas Luch, Andreas F Thünemann, Alfonso Lampen
Aluminum has gathered toxicological attention based on relevant human exposure and its suspected hazardous potential. Nanoparticles from food supplements or food contact materials may reach the human gastrointestinal tract. Here, we monitored the physico-chemical fate of aluminum-containing nanoparticles and aluminum ions when passaging an in vitro model of the human gastrointestinal tract. Small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM), ion beam microscopy (IBM), secondary ion beam mass spectrometry (TOF-SIMS), and inductively coupled plasma mass spectrometry (ICP-MS) in the single-particle mode were employed to characterize two aluminum-containing nanomaterials with different particle core materials (Al0, γAl2O3) and soluble AlCl3...
September 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28889330/desarda-s-technique-versus-lichtenstein-technique-for-the-treatment-of-primary-inguinal-hernia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
S H Emile, H Elfeki
PURPOSE: The Lichtenstein technique (LT) has been recognized as the standard treatment for inguinal hernia in adults owing to the high recurrence rates of tissue-based repairs. However, Desarda technique (DT) appeared as promising tissue-based repair that provided low incidence of recurrence without the need for implanting prosthetic or foreign materials in the inguinal canal. This meta-analysis of randomized controlled trials (RCTs) comparing DT and LT for primary inguinal hernia in adults aimed to determine which technique had better clinical outcome regarding recurrence and complication rates...
September 9, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28876694/comparing-outcomes-after-laparoscopic-totally-extraperitoneal-repair-versus-open-lichtenstein-repair-of-inguinoscrotal-hernia-at-dr-george-mukhari-academic-hospital
#9
B Shazi, M Z Koto
BACKGROUND: Inguinal hernia is a common surgical condition. Inguinal hernia can present with a wide variety of symptoms. It can even extend into the scrotum resulting in what is known as an inguinoscrotal hernia. At Dr George Mukhari Hospital, approximately 5-10% of patients with inguinal hernia present with inguinoscrotal hernia. There is paucity of data on the role of laparoscopy in the management of inguinoscrotal hernia. At our institution some of the patients with inguinoscrotal hernia are offered open (Lichtenstein) repair whilst others are offered totally extraperitoneal (TEP) laparoscopic repair...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872439/do-exercisers-with-musculoskeletal-injuries-report-symptoms-of-depression-and-stress
#10
Mia Beck Lichtenstein, Claire Gudex, Kjeld Andersen, Anders Bo Bojesen, Uffe Jørgensen
CONTEXT: Sports injuries in athletes can lead to negative emotional responses in terms of anger, anxiety, confusion, and sadness. Severe injuries can be understood as a stressful life event with increased levels of psychological distress, but injury assessment and rehabilitation typically focuses on somatic symptoms. OBJECTIVE: The primary aim of this study was to estimate the prevalence of depression and emotional stress, and measure self-rated health in regular exercisers presenting to a sports medicine clinic with musculoskeletal injury...
September 5, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28867976/health-maintenance-in-inflammatory-bowel-disease
#11
Gary R Lichtenstein
No abstract text is available yet for this article.
August 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28867967/achalasia
#12
Gary R Lichtenstein
No abstract text is available yet for this article.
July 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28858068/inflammatory-bowel-disease-predictors-and-causes-of-early-and-late-hospital-readmissions
#13
Prashant Mudireddy, Frank Scott, Alexandra Feathers, Gary R Lichtenstein
BACKGROUND AND AIMS: The rate of hospital readmission after discharge has been studied extensively in chronic conditions such as hepatic cirrhosis, diabetes mellitus, chronic obstructive pulmonary disease, and heart failure. Causative factors associated with hospital readmission have not been adequately investigated in patients with inflammatory bowel disease (IBD). We studied the rate, causes, and factors that predict readmissions at 1 month, 3 months, and 1 year in patients with IBD...
August 29, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28854569/linking-smokers-to-a-quitline-randomized-controlled-effectiveness-trial-of-a-support-person-intervention-that-targets-non-smokers
#14
Christi A Patten, Raymond Boyle, David Tinkelman, Tabetha A Brockman, Amy Lukowski, Paul A Decker, Joanne D'Silva, Edward Lichtenstein, Shu-Hong Zhu
Evidence-based treatments (e.g. quitlines) are greatly underutilized by smokers limiting their public health impact. A three-session phone intervention for nonsmoking family members and friends (i.e. support persons) was successful for increasing smoker quitline enrollment. To enhance the intervention's potential translatability, in this study, we delivered treatment for the non-smoker within ongoing quitline services and compared the efficacy of the three-call intervention to a streamlined version (one call)...
August 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/28836257/-efficacy-comparison-of-the-laparoscopic-total-extraperitoneal-prosthetic-and-the-lichtenstein-herniorrhaphy-for-inguinal-hernia
#15
Yiliang Li, Zhi Wang, Lemu Ke, Fuzeng Su, Cheng Zhang, Huiling Li, Zhi Du, Zhikai Zhu, Song Li
OBJECTIVE: To compare the efficacy and safety between laparoscopic total extraperitoneal prosthetic (TEP) and Lichtenstein herniorrhaphy in the treatment of inguinal hernia (IH). METHODS: Clinical data of 158 IH patients at our hospital from October 2015 to October 2016 were retrospectively analyzed. Among 158 patients, 85 patients underwent TEP (TEP group), and 73 underwent Lichtenstein herniorrhaphy(Lichtenstein group). Patients of TEP group received general anesthesia...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28835820/the-coexistence-of-psychiatric-and-gastrointestinal-problems-in-children-with-restrictive-eating-in-a-nationwide-swedish-twin-study
#16
Jakob Täljemark, Maria Råstam, Paul Lichtenstein, Henrik Anckarsäter, Nóra Kerekes
BACKGROUND: Restrictive eating problems are rare in children but overrepresented in those with neurodevelopmental problems. Comorbidities decrease wellbeing in affected individuals but research in the area is relatively scarce. This study describes phenotypes, regarding psychiatric and gastrointestinal comorbidities, in children with restrictive eating problems. METHODS: A parental telephone interview was conducted in 9- or 12-year old twins (n = 19,130) in the Child and Adolescent Twin Study in Sweden...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28811798/an-experience-with-mesh-versus-darn-repair-in-inguinal-hernias
#17
Gulshan Ali Memon, Syed Kashif Ali Shah, Habib-Ur-Rehman
BACKGROUND & OBJECTIVE: The inguinal hernia accounts for 50 percent in old age males. A Lichtenstein type of operation has now become the method of choice in most developed countries but in the developing world traditional simple suture repair is still in common practice in resource limited hospitals due to the scarcity and expensive nature of the commercial prosthetic mesh. Our objective was to compare the rates of complications in Lichtenstein repair to tension free Darn repair. METHODS: Ninety two male patients from 20-60 years of age reported for direct or indirect inguinal hernia with open Mesh/Lichtenstein or darn repair in emergency or electively from January 2014 to December 2015 were enrolled in this prospective randomized control trial (RCT)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28800093/omega-3-fatty-acids-and-cardiovascular-disease-summary-of-the-2016-agency-of-healthcare-research-and-quality-evidence-review
#18
REVIEW
Ethan M Balk, Alice H Lichtenstein
We summarize the 2016 update of the 2004 Agency of Healthcare Research and Quality's evidence review of omega-3 fatty acids and cardiovascular disease (CVD). The overall findings for the effects of marine oil supplements on intermediate CVD outcomes remain largely unchanged. There is high strength of evidence, based on numerous trials, of no significant effects of marine oils on systolic or diastolic blood pressures, but there are small, yet statistically significant increases in high density lipoprotein and low density lipoprotein cholesterol concentrations...
August 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28799538/local-magnetic-moments-in-iron-and-nickel-at-ambient-and-earth-s-core-conditions
#19
A Hausoel, M Karolak, E Şaşιoğlu, A Lichtenstein, K Held, A Katanin, A Toschi, G Sangiovanni
Some Bravais lattices have a particular geometry that can slow down the motion of Bloch electrons by pre-localization due to the band-structure properties. Another known source of electronic localization in solids is the Coulomb repulsion in partially filled d or f orbitals, which leads to the formation of local magnetic moments. The combination of these two effects is usually considered of little relevance to strongly correlated materials. Here we show that it represents, instead, the underlying physical mechanism in two of the most important ferromagnets: nickel and iron...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28791709/risk-of-being-convicted-of-theft-and-other-crimes-in-anorexia-nervosa-and-bulimia-nervosa-a-prospective-cohort-study-in-a-swedish-female-population
#20
Shuyang Yao, Ralf Kuja-Halkola, Laura M Thornton, Claes Norring, Catarina Almqvist, Brian M D'Onofrio, Paul Lichtenstein, Niklas Långström, Cynthia M Bulik, Henrik Larsson
OBJECTIVE: We examined epidemiological associations between anorexia nervosa (AN) and bulimia nervosa (BN) and risks of committing theft and other crimes in a nationwide female population. METHOD: Females born in Sweden during 1979-1998 (N = 957,106) were followed from age 15 for up to 20 years using information on clinically diagnosed AN and BN (exposures), convictions of theft and other crimes (outcomes), psychiatric comorbidities, and familial relatedness from Swedish national registers...
September 2017: International Journal of Eating Disorders
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