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https://www.readbyqxmd.com/read/29141948/a-phase-i-study-of-romidepsin-and-pralatrexate-reveals-marked-activity-in-relapsed-and-refractory-t-cell-lymphoma
#1
Jennifer E Amengual, Renee Lichtenstein, Jennifer Lue, Ahmed Sawas, Changchun Deng, Emily Lichtenstein, Karen Khan, Laine Atkins, Aishling Rada, Hye A Kim, Codruta Chiuzan, Matko Kalac, Enrica Marchi, Lorenzo Falchi, Mark A Francescone, Lawrence Schwartz, Serge Cremers, Owen A O'Connor
The peripheral T-cell lymphomas (PTCL) are a group of rare malignancies characterized by chemotherapy insensitivity and poor prognosis. Romidepsin and pralatrexate were approved by the U.S. FDA for patients with relapsed/refractory PTCL, exhibiting response rates of 25% and 29% respectively. Based on synergy of the combination in preclinical models of PTCL, we initiated a phase I study of pralatrexate plus romidepsin in patients with relapsed/refractory lymphoma (ClinicalTrials.gov (NCT01947140)). This was a single institution dose-escalation phase I study of pralatrexate plus romidepsin designed to determine the dose limiting toxicities (DLT), maximum tolerated dose (MTD), pharmacokinetic profile and response rates...
November 15, 2017: Blood
https://www.readbyqxmd.com/read/29133949/a-total-population-multigenerational-family-clustering-study-of-autoimmune-diseases-in-obsessive-compulsive-disorder-and-tourette-s-chronic-tic-disorders
#2
D Mataix-Cols, E Frans, A Pérez-Vigil, R Kuja-Halkola, C Gromark, K Isomura, L Fernández de la Cruz, E Serlachius, J F Leckman, J J Crowley, C Rück, C Almqvist, P Lichtenstein, H Larsson
The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29129535/genetic-influence-on-eye-movements-to-complex-scenes-at-short-timescales
#3
Daniel P Kennedy, Brian M D'Onofrio, Patrick D Quinn, Sven Bölte, Paul Lichtenstein, Terje Falck-Ytter
Where one looks within their environment constrains one's visual experiences, directly affects cognitive, emotional, and social processing [1-4], influences learning opportunities [5], and ultimately shapes one's developmental path. While there is a high degree of similarity across individuals with regard to which features of a scene are fixated [6-8], large individual differences are also present, especially in disorders of development [9-13], and clarifying the origins of these differences is essential to understand the processes by which individuals develop within the complex environments in which they exist and interact...
November 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29118063/dietary-fat-friend-or-foe
#4
Cara B Ebbeling, Ian S Young, Alice H Lichtenstein, David S Ludwig, Michelle McKinley, Rafael Perez-Escamilla, Eric Rimm
No abstract text is available yet for this article.
November 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29112654/within-family-analysis-of-interpregnancy-interval-and-adverse-birth-outcomes
#5
Quetzal A Class, Martin E Rickert, Anna S Oberg, Ayesha C Sujan, Catarina Almqvist, Henrik Larsson, Paul Lichtenstein, Brian M DʼOnofrio
OBJECTIVE: To examine associations among interpregnancy interval, the duration from the preceding birth to the conception of the next-born index child, and adverse birth outcomes using designs that adjust for measured and unmeasured factors. METHODS: In this prospective cohort study, we used population-based Swedish registries from 1973 to 2009 to estimate the associations between interpregnancy interval (referent 18-23 months) and adverse birth outcomes (ie, preterm birth [less than 37 weeks of gestation], low birth weight [LBW; less than 2,500 g], small for gestational age [SGA; greater than 2 SDs below average weight for gestational age])...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29104029/nasolabial-flap-improves-healing-in-medication-related-osteonecrosis-of%C3%A2-the-jaw
#6
Juliana Lemound, Thomas Muecke, Alexander-Nicolai Zeller, Jürgen Lichtenstein, André Eckardt, Nils-Claudius Gellrich
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is an adverse side effect of antiresorptive and antiangiogenic therapeutic agents that is difficult to treat owing to its high relapse rate. The aim of the present study was to determine whether patients with MRONJ treated using decortication and a nasolabial flap compared with those who underwent decortication with mucoperiosteal flaps have better outcomes regarding stable wound closure. MATERIALS AND METHODS: Two groups of patients with MRONJ and intraoral exposed bone were evaluated in a cohort clinical study retrospectively...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29099209/band-filling-control-of-the-dzyaloshinskii-moriya-interaction-in-weakly-ferromagnetic-insulators
#7
G Beutier, S P Collins, O V Dimitrova, V E Dmitrienko, M I Katsnelson, Y O Kvashnin, A I Lichtenstein, V V Mazurenko, A G A Nisbet, E N Ovchinnikova, D Pincini
We observe and explain theoretically a dramatic evolution of the Dzyaloshinskii-Moriya interaction (DMI) in the series of isostructural weak ferromagnets, MnCO_{3}, FeBO_{3}, CoCO_{3}, and NiCO_{3}. The sign of the interaction is encoded in the phase of the x-ray magnetic diffraction amplitude, observed through interference with resonant quadrupole scattering. We find very good quantitative agreement with first-principles electronic structure calculations, reproducing both sign and magnitude through the series, and propose a simplified "toy model" to explain the change in sign with 3d shell filling...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29098170/interobserver-variability-in-tumor-contouring-affects-the-use-of-radiomics-to-predict-mutational-status
#8
Qiao Huang, Lin Lu, Laurent Dercle, Philip Lichtenstein, Yajun Li, Qian Yin, Min Zong, Lawrence Schwartz, Binsheng Zhao
Radiomic features characterize tumor imaging phenotype. Nonsmall cell lung cancer (NSCLC) tumors are known for their complexity in shape and wide range in density. We explored the effects of variable tumor contouring on the prediction of epidermal growth factor receptor (EGFR) mutation status by radiomics in NSCLC patients treated with a targeted therapy (Gefitinib). Forty-six early stage NSCLC patients (EGFR mutant:wildtype = 20:26) were included. Three experienced radiologists independently delineated the tumors using a semiautomated segmentation software on a noncontrast-enhanced baseline and three-week post-therapy CT scan images that were reconstructed using 1...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29097934/correlation-of-18f-fdg-pet-mre-metrics-with-inflammatory-biomarkers-in-patients-with-crohn-s-disease-a-pilot-study
#9
Liran Domachevsky, Haim Leibovitzh, Irit Avni-Biron, Lev Lichtenstein, Natalia Goldberg, Meital Nidam, David Groshar, Hanna Bernstine, Ofer Ben-Bassat
Background: To investigate the association between 18F-FDG (Fluorodeoxyglucose) PET (positron emission tomography)/MRE (magnetic resonance enterography) metrics with the inflammatory biomarkers fecal calprotectin and C-reactive protein (CRP) in patients with Crohn's disease (CD). Methods: This prospective pilot study was institutional review board (IRB) approved with informed consent obtained. Consecutive CD patients were referred to 18F-FDG PET/MRE. Patients in whom colonoscopy was performed and CRP and fecal calprotectin levels were measured were included...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29093499/erratum-the-bethe-slater-curve-revisited-new-insights-from-electronic-structure-theory
#10
R Cardias, A Szilva, A Bergman, I Di Marco, M I Katsnelson, A I Lichtenstein, L Nordström, A B Klautau, O Eriksson, Y O Kvashnin
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29090104/late-ps-aeruginosa-inguinal-mesh-infection-12-years-after-the-initial-operation-report-of-the-case-and-short-review-of-the-literature
#11
Dimitrios Filippou
Inguinal hernia mesh repair is one of the most frequent operations performed worldwide. The Lichtenstein technique and its various modifications are the most popular operations for groin hernia repair. The rate of surgical site infection (SSI) following inguinal hernia repair ranges between 0 and 14% in various series. Most of these infections developed early postoperatively. The incidence of late mesh infection following open inguinal hernia repair still remains unclear and highly variable. Late deep mesh infections are relatively rare specially after more than 10 years...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29063298/four-dimensional-computed-tomography-clinical-impact-for-patients-with-primary-hyperparathyroidism
#12
Yuan Tian, Sharman Tan Tanny, Paul Einsiedel, Meir Lichtenstein, Damien L Stella, Pramit M Phal, Julie A Miller
BACKGROUND: In recent years, four-dimensional computed tomography (4DCT) has emerged as a new localization study for primary hyperparathyroidism (pHPT). OBJECTIVE: We aimed to assess the added value of 4DCT in our institution in the first 4 years of use. METHODS: A retrospective cohort study was conducted from February 2004 to June 2015. Since 2011, patients over 50 years of age without concordant sestamibi-SPECT (SeS) and ultrasound (US) findings underwent 4DCT...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29046304/comparison-among-criteria-to-define-successful-weight-loss-maintainers-and-regainers-in-the-action-for-health-in-diabetes-look-ahead-and-diabetes-prevention-program-trials
#13
Samantha E Berger, Gordon S Huggins, Jeanne M McCaffery, Alice H Lichtenstein
Background: Given the low rates of successful weight maintenance after lifestyle-induced weight loss, it is critical to develop approaches that distinguish successful weight-loss maintainers from regainers.Objective: The aim of this study was to compare published categorization criteria that differentiate maintainers and regainers via quantitative agreement.Design: The study used publicly available data from Look AHEAD (Action for Health in Diabetes; n = 1791) and Diabetes Prevention Program (DPP; n = 613) participants with ≥3% initial weight loss after lifestyle interventions and 4-y follow-up data...
October 18, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29044606/the-genetic-architecture-of-photosynthesis-and-plant-growth-related-traits-in-tomato
#14
Franklin Magnum de Oliveira Silva, Gabriel Lichtenstein, Saleh Alseekh, Laise Rosado-Souza, Mariana Conte, Vanessa Fuentes Suguiyama, Bruno Silvestre Lira, Dimitrios Fanourakis, Björn Usadel, Leonardo Lopes Bhering, Fábio M DaMatta, Ronan Sulpice, Wagner L Araújo, Magdalena Rossi, Nathalia de Setta, Alisdair R Fernie, Fernando Carrari, Adriano Nunes-Nesi
To identify genomic regions involved in the regulation of fundamental physiological processes such as photosynthesis and respiration, a population of Solanum pennellii introgression lines (ILs) was analyzed. We determined phenotypes for physiological, metabolic and growth related traits, including gas-exchange and chlorophyll fluorescence parameters. Data analysis allowed the identification of 208 physiological and metabolic QTL with 33 of these being associated to smaller intervals of the genomic regions, termed BINs...
October 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29040553/longitudinal-depression-or-anxiety-in-mothers-and-offspring-asthma-a-swedish-population-based-study
#15
Bronwyn K Brew, Cecilia Lundholm, Alexander Viktorin, Paul Lichtenstein, Henrik Larsson, Catarina Almqvist
Background: Previous research has found that maternal stress during pregnancy increases the risk of offspring asthma. However, whether this association is consistent with a causal interpretation has never been tested. The objective is to determine whether there is a critical exposure period for maternal depression or anxiety on offspring asthma or whether cumulative exposure is most important, and to investigate evidence of confounding. Methods: The study population included all children born in Sweden from July 2006 to December 2009 (n = 360 526)...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040155/the-complexities-of-fibromyalgia-and-its-comorbidities
#16
Adi Lichtenstein, Shmuel Tiosano, Howard Amital
PURPOSE OF REVIEW: Fibromyalgia syndrome (FMS) is defined as chronic, widespread musculoskeletal pain and tenderness with concomitant mood and cognitive dysfunction. Several comorbidities have been reported to be associated with FMS. We reviewed the literature concerning the most noteworthy chronic conditions associated with FMS. RECENT FINDINGS: There is mounting evidence displaying the concurrence of fibromyalgia and coexisting medical and psychiatric conditions...
October 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29038642/diagnosing-and-treating-eosinophilic-esophagitis
#17
Gary R Lichtenstein
No abstract text is available yet for this article.
September 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29033979/participation-in-cooperative-prey-capture-and-the-benefits-gained-from-it-are-associated-with-individual-personality
#18
James L L Lichtenstein, Colin M Wright, Lauren P Luscuskie, Graham A Montgomery, Noa Pinter-Wollman, Jonathan N Pruitt
In animal societies, behavioral idiosyncrasies of the individuals often guide which tasks they should perform. Such personality-specific task participation can increase individual task efficiency, thereby improving group performance. While several recent studies have documented group-level benefits of within-group behavioral (i.e., personality) diversity, how these benefits are realized at the individual level is unclear. Here we probe the individual-level benefits of personality-driven task participation in the social spider Stegodyphus dumicola...
October 1, 2017: Current Zoology
https://www.readbyqxmd.com/read/29029881/comparison-of-self-gripping-mesh-and-sutured-mesh-in-open-inguinal-hernia-repair-a-meta-analysis-of-long-term-results
#19
REVIEW
Marijke Molegraaf, Ruth Kaufmann, Johan Lange
BACKGROUND: Complications after inguinal hernioplasty pose a significant burden on individual patients and society because of high numbers of repair procedures. Recently, the long-term results of a self-gripping ProGrip mesh for open inguinal hernia repair have become available. The aim of this meta-analyses was to compare these long-term results with the results of a Lichtenstein hernioplasty with a sutured mesh focusing on chronic pain, recurrence rate, foreign body sensation, and operation duration...
October 10, 2017: Surgery
https://www.readbyqxmd.com/read/29019556/comparative-study-of-postoperative-pain-between-the-lichtenstein-and-laparoscopy-surgical-techniques-for-the-treatment-of-unilateral-primary-inguinal-hernia
#20
Leandro Mendonça Pedroso, Renato Miranda DE-Melo, Nelson Jorge DA-Silva-Jr
BACKGROUND: There are several surgical treatment options for inguinal hernia; however, there is no consensus on the literature identifying which surgical technique promotes less postoperative pain. AIM: To compare the intensity of postoperative pain between the surgical techniques Lichtenstein and transabdominal pre-peritoneal laparoscopy for the treatment of unilateral primary inguinal hernia. METHODS: Were included 60 patients, of which 30 were operated through the Lichtenstein technique and 30 patients through the transabdominal pre-peritoneal laparoscopy...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
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