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Photosensitisers

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https://www.readbyqxmd.com/read/28870132/differential-modes-of-photosensitisation-in-cancer-cells-by-berberine-and-coralyne
#1
Rahul Bhattacharyya, Bhaskar Saha, Mrityunjaya Tyagi, Sandip K Bandyopadhyay, Birija Sankar Patro, Subrata Chattopadhyay
In this study, we demonstrated that the cytotoxicity of the protoberberine alkaloids such as coralyne, berberine and jatrorrhizine to several human cancer cell lines can be improved significantly in combination with UVA exposure. However, the phototoxic property of coralyne was much higher than that of the other two alkaloids. The combination of coralyne and UVA (designated as CUVA) induced oxygen-independent cytotoxicity in the human lung cancer A549 cells by producing more lethal DNA double-strand breaks, and the effect was mediated via the replication machinery...
September 5, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28842332/tumor-acidity-activatable-manganese-phosphate-nanoplatform-for-amplification-of-photodynamic-cancer-therapy-and-magnetic-resonance-imaging
#2
Yongwei Hao, Cuixia Zheng, Lei Wang, Jinjie Zhang, Xiuxiu Niu, Qingling Song, Qianhua Feng, Hongjuan Zhao, Li Li, Hongling Zhang, Zhenzhong Zhang, Yun Zhang
Amorphous biodegradable metal phosphate nanomaterials are considered to possess great potential in cancer theranostic application due to their promise in providing ultra-sensitive pH-responsive therapeutic benefits and diagnostic functions simultaneously. Here we report the synthesis of photosensitising and acriflavine-carrying amorphous porous manganese phosphate (PMP) nanoparticles with ultra-sensitive pH-responsive degradability and their applications for a photoactivable synergistic nanosystem that imparts reactive oxygen species (ROS) induced cytotoxicity in synchrony with hypoxia-inducible factor 1α/vascular endothelial growth factor (HIF1α/VEGF) inhibitor that suppresses tumor growth and treatment escape signalling pathway...
August 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28822258/photochemical-oxidation-of-dimethylsulphide-to-dimethylsulphoxide-in-estuarine-and-coastal-waters
#3
Günther Uher, J Julian Pillans, Angela D Hatton, Robert C Upstill-Goddard
Dimethylsulphide (DMS) photo-oxidation and dimethylsulphoxide (DMSO) photoproduction were estimated in 26 laboratory irradiations of coastal samples from NE England (Tyne estuary) and W Scotland (Loch Linnhe and River Nant at Taynuilt). Pseudo-first order rate constants of DMS photo-oxidation (0.038 h(-1) to 0.345 h(-1)) and DMSO photo-production (0.017 h(-1) to 0.283 h(-1)) varied by one order of magnitude and were lowest in the coastal North Sea. Estuarine samples (salinity S < 30) had a mean DMSO yield of 96 ± 16% (n = 14), consistent with 1:1 M conversion via photosensitised oxidation by singlet oxygen...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28795744/a-cell-selective-glutathione-responsive-tris-phthalocyanine-as-a-smart-photosensitiser-for-targeted-photodynamic-therapy
#4
Sun Y S Chow, Shirui Zhao, Pui-Chi Lo, Dennis K P Ng
A biotin-conjugated disulfide-linked tris(phthalocyanine) has been synthesised and characterised. As shown by electronic absorption and steady-state fluorescence spectroscopy methods, the compound remains non-aggregated in N,N-dimethylformamide, but is significantly aggregated in phosphate buffered saline with 1% Cremophor EL. The reduction in fluorescence intensity and singlet oxygen generation efficiency as compared with the monomeric counterpart suggests that the tris(phthalocyanine) exhibits an excellent self-quenching effect, particularly in an aqueous medium...
August 29, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28782769/highly-phosphorescent-tungsten-0-carbonyl-pyridyl-imidazole-complexes-as-photosensitisers
#5
Jia Jin Lee, Chew Pheng Yap, Tsz Sian Chwee, Wai Yip Fan
Photoluminescence data are reported for two W(CO)4L complexes (L = 2-(1H-imidazol-2-yl)pyridine and 2-(2'-pyridyl)benzimidazole) in room-temperature solutions. The bidentate ligands consist of a pyridine and an imidazole moiety connected by a C-C bond. The complexes have been found to exhibit enhanced phosphorescence from the metal-to-ligand charge transfer (MLCT) excited state with quantum yields in the order of 10(-3), almost two orders of magnitude higher than those reported for W(CO)4(diimine) complexes...
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28758725/superhydrophobic-and-white-light-activated-bactericidal-surface-through-a-simple-coating
#6
Gi Byoung Hwang, Adnan Patir, Elaine Allan, Sean P Nair, Ivan P Parkin
Bacterial adhesion and proliferation on surfaces are a challenge in medical and industrial fields. Here, a simple one-step technique is reported to fabricate self-cleaning and bactericidal surfaces. White, blue, and violet paints were produced using titanium dioxide nanoparticles, 1H,1H,2H,2H-perfluorooctyltriethoxysilane, crystal violet, toluidine Blue O, and ethanol solution. All of the painted surfaces showed superhydrophobicity in air, and even after hexadecane oil contamination, they retained water repellency and self-cleaning properties...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28729656/endolysosomal-targeting-of-a-clinical-chlorin-photosensitiser-for-light-triggered-delivery-of-nano-sized-medicines
#7
Elnaz Yaghini, Ruggero Dondi, Kunal M Tewari, Marilena Loizidou, Ian M Eggleston, Alexander J MacRobert
A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemical internalisation (PCI) is a technique for inducing cytosolic release of the entrapped agents that harnesses sub-lethal photodynamic therapy (PDT) using a photosensitiser that localises in endolysosomal membranes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704661/direct-and-indirect-photolysis-of-seven-micropollutants-in-secondary-effluent-from-a-wastewater-lagoon
#8
Yufei Wang, Felicity A Roddick, Linhua Fan
The photodegradation of seven micropollutants commonly found in municipal wastewater, namely caffeine, carbamazepine, diuron, simazine, sulfamethoxazole, triclosan and 2,4-D, was investigated in pure water and secondary effluent to understand the direct and indirect photolysis of these compounds under natural sunlight irradiation. Sulfamethoxazole and triclosan were readily photodegraded with half-lives of 5.8 and 1.8 h, respectively, whilst the others were relatively resistant towards sunlight irradiation...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28702636/fe3o4-au-msio2-as-an-enhancing-nanoplatform-for-rose-bengal-photodynamic-activity
#9
I Rosa-Pardo, M Roig-Pons, A A Heredia, J V Usagre, A Ribera, R E Galian, J Pérez-Prieto
A novel nanoplatform composed of three types of materials with different functionalities, specifically core-shell Fe3O4@Au nanoparticles encapsulated near the outer surface of mesoporous silica (mSiO2) nanoparticles, has been successfully synthesised and used to enhance the efficiency of a photosensitiser, namely Rose Bengal, in singlet oxygen generation. Fe3O4 is responsible for the unusual location of the Fe3O4@Au nanoparticle, while the plasmonic shell acts as an optical antenna. In addition, the mesoporous silica matrix firmly encapsulates Rose Bengal by chemical bonding inside the pores, thus guaranteeing its photostability, and in turn making the nanosystem biocompatible...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28699738/a-molecular-combination-of-zinc-ii-phthalocyanine-and-tamoxifen-derivative-for-dual-targeting-photodynamic-therapy-and-hormone-therapy
#10
Feng-Ling Zhang, Mei-Ru Song, Gan-Kun Yuan, Huan-Nian Ye, Ye Tian, Ming-Dong Huang, Jin-Ping Xue, Zhi-Hong Zhang, Jian-Yong Liu
The combination of photodynamic therapy and other cancer treatment modalities is a promising strategy to enhance therapeutic efficacy and reduce side effects. In this study, a tamoxifen-zinc(II) phthalocyanine conjugate linked by a triethylene glycol chain has been synthesized and characterized. Having tamoxifen as the targeting moiety, the conjugate shows high specific affinity to MCF-7 breast cancer cells overexpressed estrogen receptors (ERs) and tumor tissues, therefore leading to a cytotoxic effect in the dark due to the cytostatic tamoxifen moiety, and a high photocytotoxicity due to the photosensitizing phthalocyanine unit against the MCF-7 cancer cells...
August 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28699222/in-vitro-fungicidal-effects-of-methylene-blue-at-625-nm
#11
J Stephen Guffey, William Payne, Wilson Roegge
The aim of the study is to confirm the effectiveness of photodynamic therapy (PDT) as a significant inhibitor of Trichophyton rubrum (T. rubrum) and to determine the most appropriate dose and rate of delivery. Trichophyton rubrum is the most common dermatophyte worldwide, responsible for the majority of superficial fungal infections. The traditional treatment of T. rubrum has known adverse effects. An alternative treatment is warranted. Photosensitised T. rubrum specimens were treated with 625-nm light at doses of 3, 12, 24, 40 and 60 J/cm(2) ...
July 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28694503/cd44v8-10-as-a-potential-theranostic-biomarker-for-targeting-disseminated-cancer-cells-in-advanced-gastric-cancer
#12
Eun-Seok Choi, Hyunjin Kim, Hyung-Pyo Kim, Yongdoo Choi, Sung-Ho Goh
Gastric cancer is the third most common cause of cancer mortality, and the survival rate of stage IV advanced gastric cancer (AGC) patients with distant metastasis is very low. Thus, the detection and eradication of disseminated cancer cells by targeting cell surface molecules in AGC would improve patient survival. The hyaluronic acid receptor, CD44, has various isoforms generated by alternative splicing, and some isoforms are known to be correlated to gastric cancer. In this study, to find out the most appropriate CD44v for targeting AGC, we analysed the expression differences of CD44 isoforms at the mRNA level in stomach cancer cell lines as well as in 74 patients with AGC by using exon-specific qRT-PCR...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28664961/carbon-dots-as-photosensitisers-for-solar-driven-catalysis
#13
Georgina A M Hutton, Benjamin C M Martindale, Erwin Reisner
Artificial photosynthesis is the mimicry of the natural process of solar energy conversion into chemical energy carriers. Photocatalytic systems that combine light-harvesting materials and catalysts in solution or suspension provide a promising route towards this goal. A key requirement for a sustainable solar fuel production system is a low-cost, stable and non-toxic light harvester. Photoluminescent carbon nanoparticles, carbon dots (CDs), are promising emerging light-harvesters for photocatalytic fuel production systems...
June 30, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28662924/anticancer-effects-elicited-by-combination-of-rubus-extract-with-phthalocyanine-photosensitiser-on-mcf-7-human-breast-cancer-cells
#14
Blassan P George, Heidi Abrahamse, Nanjundaswamy M Hemmaragala
BACKGROUND: Photodynamic therapy (PDT) is a novel approach for the treatment of cancer and other related diseases. Breast cancer remains the most common cause of cancer-related death in women. This study was carried out to investigate the photosensitizing capacity of Rubus fairholmianus root acetone extract (RFRA) in vitro. METHODS: RFRA was coupled with phthalocyanine photosensitizer to enhance the therapeutic properties on MCF-7 breast cancer cells. Comparatively low dose photosensitizer (PS) and Rubus extract have been used for the conjugation as it induces cell death at low doses...
September 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28655934/oxidative-stress-induced-by-uva-photoactivation-of-the-tryptophan-uvb-photoproduct-6-formylindolo-3-2-b-carbazole-ficz-inhibits-nucleotide-excision-repair-in-human-cells
#15
Reto Brem, Peter Macpherson, Melisa Guven, Peter Karran
Potentially mutagenic DNA lesions induced by UVB (wavelengths 280-320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer. The carcinogenicity of the more abundant UVA (320-400 nm) is less well understood but is generally regarded to reflect its interaction with cellular chromophores that act as photosensitisers. The arylhydrocarbon receptor agonist 6-formylindolo[3,2-b] carbazole (FICZ), is a UVB photoproduct of tryptophan and a powerful UVA chromophore. Combined with UVA, FICZ generates reactive oxygen species (ROS) and induces oxidative DNA damage...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654772/evidence-for-the-presence-of-cell-surface-bound-and-intracellular-bactericidal-toxins-in-the-dinoflagellate-heterocapsa-circularisquama
#16
Kichul Cho, Li Wencheng, Satoshi Takeshita, Jung-Kil Seo, Young-Ho Chung, Daekyung Kim, Tatsuya Oda
Heterocapsa circularisquama, a harmful dinoflagellate, has multiple haemolytic toxins that are considered to be involved in the toxic mechanism against shellfish and certain species of zooplankton. To evaluate the further nature of the toxins of H. circularisquama, we investigated its effects on several species of bacteria. By colony formation assay, we found that H. circularisquama had antibacterial activity toward the marine bacterium Vibrio alginolyticus in a cell density-dependent manner. When the inoculated bacterial cells were co-cultured with H...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28623822/a-novel-photosensitization-treatment-for-the-inactivation-of-fungal-spores-and-cells-mediated-by-curcumin
#17
Fahad Al-Asmari, Ram Mereddy, Yasmina Sultanbawa
The global concerns regarding the emergence of fungicide-resistant strains and the impact of the excessive use of fungicidal practises on our health, food, and environment have increased, leading to a demand for alternative clean green technologies as treatments. Photosensitization is a treatment that utilises a photosensitiser, light and oxygen to cause cell damage to microorganisms. The effect of photosensitization mediated by curcumin on Aspergillus niger, Aspergillus flavus, Penicillium griseofulvum, Penicillium chrysogenum, Fusarium oxysporum, Candida albicans and Zygosaccharomyces bailii was investigated using three methods...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28619615/evaluation-of-antimicrobial-activity-of-association-of-chlorhexidine-to-photosensitizer-used-in-photodynamic-therapy-in-root-canals-infected-by-enterococcus-faecalis
#18
Matheus Albino Souza, Guilherme Lima, Bianca Pazinatto, Karolina Frick Bischoff, Huriel Scartazzini Palhano, Doglas Cecchin
INTRODUCTION: The aim of the present study was to evaluate, in vitro, the influence of the addition of chlorhexidine to photosensitiser in the antimicrobial activity of photodynamic therapy in root canals infected by Enterococcus faecalis. METHODS: The root canals of 50 single-rooted human extracted teeth were enlarged up to a file F3 of Pro-Taper system, autoclaved, inoculated with Enterococcus faecalis and incubated for 14days. The samples were divided into five groups (n=10) according to the protocol of decontamination: G1 (control group) - no procedure was performed; G2-photosensitiser (0...
September 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28579544/could-clinical-photochemical-internalisation-be-optimised-to-avoid-neuronal-toxicity
#19
Caitriona O'Rourke, Colin Hopper, Alexander J MacRobert, James B Phillips, Josephine H Woodhams
Photochemical Internalisation (PCI) is a novel drug delivery technology in which low dose photodynamic therapy (PDT) can selectively rupture endo/lysosomes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release in the treatment of cancer. For PCI to be developed further, it is important to understand whether nerve damage is an impending side effect when treating cancers within or adjacent to nervous system tissue. Dorsal root ganglion (DRG) neurons and their associated satellite glia were subjected to PCI treatment in a 3D co-culture system following incubation with photosensitisers: meso-tetraphenylporphine (TPPS2a) or tetraphenylchlorin disulfonate (TPCS2a) and Bleomycin...
August 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28530733/photophysical-properties-singlet-oxygen-generation-efficiency-and-cytotoxic-effects-of-aloe-emodin-as-a-blue-light-photosensitizer-for-photodynamic-therapy-in-dermatological-treatment
#20
Lixin Zang, Huimin Zhao, Xueyu Ji, Wenwu Cao, Zhiguo Zhang, Peisong Meng
Conventional photodynamic therapy (PDT) uses red light for deeper penetration. A natural compound, aloe emodin (AE) with anticancer and photosensitising capabilities, excited by blue light, is proposed to treat superficial diseases. The photophysical properties and singlet oxygen quantum yield (ΦΔ) of AE, as well as the cytotoxic effects of AE on human cells, were investigated. The absorption and emission spectra of AE were analyzed. The ΦΔ of AE was measured by a relative method. In order to study the relationship between ΦΔ and the oxygen concentration, the dependence of ΦΔ on the oxygen concentration was investigated...
July 1, 2017: Photochemical & Photobiological Sciences
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