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Photosensitisers

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https://www.readbyqxmd.com/read/29119188/catechol-tio2-hybrids-for-photocatalytic-h2-production-and-photocathode-assembly
#1
Katherine L Orchard, Daisuke Hojo, Katarzyna P Sokol, Meng-Ju Chan, Naoki Asao, Tadafumi Adschiri, Erwin Reisner
Visible-light driven H2 evolution in water is achieved using catechol-photosensitised TiO2 nanoparticles with a molecular nickel catalyst. Layer-by-layer immobilisation of catechol-TiO2 onto tin-doped indium oxide electrodes generates photocathodic currents in the presence of an electron acceptor. This approach represents a new strategy for controlling photocurrent direction in dye-sensitised photoelectrochemical applications.
November 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29115314/molecular-photosensitisers-for-two-photon-photodynamic-therapy
#2
F Bolze, S Jenni, A Sour, V Heitz
Two-photon excitation has attracted the attention of biologists, especially after the development of two-photon excited microscopy in the nineties. Since then, new applications have rapidly emerged such as the release of biologically active molecules and photodynamic therapy (PDT) using two-photon excitation. PDT, which requires a light-activated drug (photosensitiser), is a clinically approved and minimally invasive treatment for cancer and for non-malignant diseases. This feature article focuses on the engineering of molecular two-photon photosensitisers for PDT, which should bring important benefits to the treatment, increase the treatment penetration depth with near-infrared light excitation, improve the spatial selectivity and reduce the photodamage to healthy tissues...
November 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29111390/treatment-of-peritoneal-carcinomatosis-with-photodynamic-therapy-systematic-review-of-current-evidence
#3
REVIEW
Muhammad Qutayba Almerie, Gemma Gossedge, Kathleen E Wright, David G Jayne
BACKGROUND: Peritoneal carcinomatosis results when tumour cells implant and grow within the peritoneal cavity. Treatment and prognosis vary based on the primary cancer. Although therapy with intention-to-cure is offered to selective patients using cytoreductive surgery with chemotherapy, the prognosis remains poor for most of the patients. Photodynamic therapy (PDT) is a cancer-therapeutic modality where a photosensitiser is administered to patients and exerts a cytotoxic effect on cancer cells when excited by light of a specific wavelength...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29109990/an-unexpected-journey-from-highly-tunable-phosphorescence-to-novel-photochemistry-of-1-2-3-triazole-based-complexes
#4
Paul A Scattergood, Paul I P Elliott
The photophysical properties of transition metal complexes have long attracted interest in the literature with significant research activity during the past two to three decades due to the potential exploitation of these materials in solar energy conversion, light-emitting technology, luminescence biological imaging and photodynamic therapeutic applications to name but a few. Since the advent of the facile preparation of 1,2,3-triazole-based compounds through copper(i)-catalysed cycloaddition, ligands based on this heterocycle have received widespread attention in coordination chemistry...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29105723/new-horizons-in-microbiological-food-safety-photodynamic-decontamination-based-on-a-curcumin-derivative
#5
Michael Glueck, Barbara Schamberger, Peter Eckl, Kristjan Plaetzer
Outbreaks of foodborne diseases are regularly reported worldwide. In particular, uncooked plant food is considered risky in terms of microbiological safety. Food is also the most important transmission route for resistant microorganisms from animals to humans. Photodynamic Decontamination (PDc) of foodstuff was recently introduced as a novel approach for increasing microbiological food safety. We investigated the efficiency of PDc on plant food with different geometries (flat, spherical and complex) using a two-dimensional LED array as a light source (435 nm, 33...
November 6, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29073637/tetracycline-use-and-risk-of-incident-skin-cancer-a-prospective-study
#6
Wen-Qing Li, Aaron M Drucker, Eunyoung Cho, Francine Laden, Trang VoPham, Suyun Li, Martin A Weinstock, Abrar A Qureshi
BACKGROUND: Tetracycline is a photosensitising medication that increases skin vulnerability to UV-related damage. METHODS: We prospectively examined tetracycline use and risk of incident melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) based on 213 536 participants from the Nurses' Health Study (NHS), NHS2, and Health Professionals Follow-up Study. Information on ever use of tetracycline was asked via questionnaire. Diagnoses of melanoma and SCC were pathologically confirmed...
October 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29044277/cationic-phthalocyanine-dendrimers-as-potential-antimicrobial-photosensitisers
#7
Rubén Ruiz-González, Francesca Setaro, Òscar Gulías, Montserrat Agut, Uwe Hahn, Tomás Torres, Santi Nonell
In the present study we describe the synthesis, photophysical properties and the photoinactivation performance against representative microorganisms of two families of cationic dendrimeric phthalocyanines as potential photosensitisers. Four charged dendrimeric compounds varying in their degree of ionicity (4 or 8 positive charges) and the coordinating metal (zinc or ruthenium) are compared and assessed as potential photosensitising agents in terms of their antimicrobial activity.
October 31, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29027559/photosensitised-regioselective-2-2-cycloaddition-of-cinnamates-and-related-alkenes
#8
Santosh K Pagire, Asik Hossain, Lukas Traub, Sabine Kerres, Oliver Reiser
An efficient method for the synthesis of substituted cyclobutanes from cinnamates, chalcones, and styrenes has been developed utilizing a visible-light triplet sensitisation mode. This reaction provides a diverse range of substituted cyclobutanes in high yields under mild conditions without the need of external additives. Good regioselectivity is obtained due to strong π-π-stacking of arene moieties, whereas diastereoselectivity relies on the electronic effects or ortho-substitution of the arene substrate...
November 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29017954/low-level-led-photodynamic-therapy-using-curcumin-loaded-tetraether-liposomes
#9
Lili Duse, Shashank Reddy Pinnapireddy, Boris Strehlow, Jarmila Jedelská, Udo Bakowsky
Oncological use of photodynamic therapy is an evolving field in cancer therapeutics. Photosensitisers are prone to accumulation inside healthy tissues causing undesirable effects. To avoid this, we have developed tetraether lipid liposomal formulations containing curcumin which is a naturally occurring anti-cancer substance and deemed to be safe towards healthy cells. Upon excitation with light at a specific wavelength, curcumin produces reactive oxygen species (ROS) in presence of oxygen, thereby exhibiting a cytotoxic effect towards the surrounding tissues, giving a total control on the onset of therapy...
October 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28992346/searching-for-assay-controls-for-the-fpg-and-hogg1-modified-comet-assay
#10
Peter Møller, Kim Jantzen, Mille Løhr, Maria Helena Andersen, Ditte Marie Jensen, Martin Roursgaard, Pernille Høgh Danielsen, Annie Jensen, Steffen Loft
The formamidopyrimidine DNA glycosylase (Fpg) and human 8-oxoguanine DNA glycosylase (hOGG1)-modified comet assays have been widely used in human biomonitoring studies. The purpose of this article is to assess differences in reported levels of Fpg- and hOGG1-sensitive sites in leukocytes and suggest suitable assay controls for the measurement of oxidatively damaged DNA. An assessment of the literature showed a large variation in the reported levels of Fpg-sensitive sites (range 0.05-1.31 lesions/106 bp). The levels of Fpg-sensitive sites are lower in studies where Fpg has been obtained from commercial suppliers or unknown sources as compared to Fpg from one particular non-commercial source (χ2 = 7...
September 15, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28870132/differential-modes-of-photosensitisation-in-cancer-cells-by-berberine-and-coralyne
#11
Rahul Bhattacharyya, Bhaskar Saha, Mrityunjaya Tyagi, Sandip K Bandyopadhyay, Birija Sankar Patro, Subrata Chattopadhyay
In this study, we demonstrated that the cytotoxicity of the protoberberine alkaloids such as coralyne, berberine and jatrorrhizine to several human cancer cell lines can be improved significantly in combination with UVA exposure. However, the phototoxic property of coralyne was much higher than that of the other two alkaloids. The combination of coralyne and UVA (designated as CUVA) induced oxygen-independent cytotoxicity in the human lung cancer A549 cells by producing more lethal DNA double-strand breaks, and the effect was mediated via the replication machinery...
September 5, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28842332/tumor-acidity-activatable-manganese-phosphate-nanoplatform-for-amplification-of-photodynamic-cancer-therapy-and-magnetic-resonance-imaging
#12
Yongwei Hao, Cuixia Zheng, Lei Wang, Jinjie Zhang, Xiuxiu Niu, Qingling Song, Qianhua Feng, Hongjuan Zhao, Li Li, Hongling Zhang, Zhenzhong Zhang, Yun Zhang
Amorphous biodegradable metal phosphate nanomaterials are considered to possess great potential in cancer theranostic application due to their promise in providing ultra-sensitive pH-responsive therapeutic benefits and diagnostic functions simultaneously. Here we report the synthesis of photosensitising and acriflavine-carrying amorphous porous manganese phosphate (PMP) nanoparticles with ultra-sensitive pH-responsive degradability and their application for a photoactivable synergistic nanosystem that imparts reactive oxygen species (ROS) induced cytotoxicity in synchrony with hypoxia-inducible factor 1α/vascular endothelial growth factor (HIF1α/VEGF) inhibitor that suppresses tumor growth and treatment escape signalling pathway...
August 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28822258/photochemical-oxidation-of-dimethylsulphide-to-dimethylsulphoxide-in-estuarine-and-coastal-waters
#13
Günther Uher, J Julian Pillans, Angela D Hatton, Robert C Upstill-Goddard
Dimethylsulphide (DMS) photo-oxidation and dimethylsulphoxide (DMSO) photoproduction were estimated in 26 laboratory irradiations of coastal samples from NE England (Tyne estuary) and W Scotland (Loch Linnhe and River Nant at Taynuilt). Pseudo-first order rate constants of DMS photo-oxidation (0.038 h(-1) to 0.345 h(-1)) and DMSO photo-production (0.017 h(-1) to 0.283 h(-1)) varied by one order of magnitude and were lowest in the coastal North Sea. Estuarine samples (salinity S < 30) had a mean DMSO yield of 96 ± 16% (n = 14), consistent with 1:1 M conversion via photosensitised oxidation by singlet oxygen...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28795744/a-cell-selective-glutathione-responsive-tris-phthalocyanine-as-a-smart-photosensitiser-for-targeted-photodynamic-therapy
#14
Sun Y S Chow, Shirui Zhao, Pui-Chi Lo, Dennis K P Ng
A biotin-conjugated disulfide-linked tris(phthalocyanine) has been synthesised and characterised. As shown by electronic absorption and steady-state fluorescence spectroscopy methods, the compound remains non-aggregated in N,N-dimethylformamide, but is significantly aggregated in phosphate buffered saline with 1% Cremophor EL. The reduction in fluorescence intensity and singlet oxygen generation efficiency as compared with the monomeric counterpart suggests that the tris(phthalocyanine) exhibits an excellent self-quenching effect, particularly in an aqueous medium...
August 29, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28782769/highly-phosphorescent-tungsten-0-carbonyl-pyridyl-imidazole-complexes-as-photosensitisers
#15
Jia Jin Lee, Chew Pheng Yap, Tsz Sian Chwee, Wai Yip Fan
Photoluminescence data are reported for two W(CO)4L complexes (L = 2-(1H-imidazol-2-yl)pyridine and 2-(2'-pyridyl)benzimidazole) in room-temperature solutions. The bidentate ligands consist of a pyridine and an imidazole moiety connected by a C-C bond. The complexes have been found to exhibit enhanced phosphorescence from the metal-to-ligand charge transfer (MLCT) excited state with quantum yields in the order of 10(-3), almost two orders of magnitude higher than those reported for W(CO)4(diimine) complexes...
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28758725/superhydrophobic-and-white-light-activated-bactericidal-surface-through-a-simple-coating
#16
Gi Byoung Hwang, Adnan Patir, Elaine Allan, Sean P Nair, Ivan P Parkin
Bacterial adhesion and proliferation on surfaces are a challenge in medical and industrial fields. Here, a simple one-step technique is reported to fabricate self-cleaning and bactericidal surfaces. White, blue, and violet paints were produced using titanium dioxide nanoparticles, 1H,1H,2H,2H-perfluorooctyltriethoxysilane, crystal violet, toluidine Blue O, and ethanol solution. All of the painted surfaces showed superhydrophobicity in air, and even after hexadecane oil contamination, they retained water repellency and self-cleaning properties...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28729656/endolysosomal-targeting-of-a-clinical-chlorin-photosensitiser-for-light-triggered-delivery-of-nano-sized-medicines
#17
Elnaz Yaghini, Ruggero Dondi, Kunal M Tewari, Marilena Loizidou, Ian M Eggleston, Alexander J MacRobert
A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemical internalisation (PCI) is a technique for inducing cytosolic release of the entrapped agents that harnesses sub-lethal photodynamic therapy (PDT) using a photosensitiser that localises in endolysosomal membranes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704661/direct-and-indirect-photolysis-of-seven-micropollutants-in-secondary-effluent-from-a-wastewater-lagoon
#18
Yufei Wang, Felicity A Roddick, Linhua Fan
The photodegradation of seven micropollutants commonly found in municipal wastewater, namely caffeine, carbamazepine, diuron, simazine, sulfamethoxazole, triclosan and 2,4-D, was investigated in pure water and secondary effluent to understand the direct and indirect photolysis of these compounds under natural sunlight irradiation. Sulfamethoxazole and triclosan were readily photodegraded with half-lives of 5.8 and 1.8 h, respectively, whilst the others were relatively resistant towards sunlight irradiation...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28702636/fe3o4-au-msio2-as-an-enhancing-nanoplatform-for-rose-bengal-photodynamic-activity
#19
I Rosa-Pardo, M Roig-Pons, A A Heredia, J V Usagre, A Ribera, R E Galian, J Pérez-Prieto
A novel nanoplatform composed of three types of materials with different functionalities, specifically core-shell Fe3O4@Au nanoparticles encapsulated near the outer surface of mesoporous silica (mSiO2) nanoparticles, has been successfully synthesised and used to enhance the efficiency of a photosensitiser, namely Rose Bengal, in singlet oxygen generation. Fe3O4 is responsible for the unusual location of the Fe3O4@Au nanoparticle, while the plasmonic shell acts as an optical antenna. In addition, the mesoporous silica matrix firmly encapsulates Rose Bengal by chemical bonding inside the pores, thus guaranteeing its photostability, and in turn making the nanosystem biocompatible...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28699738/a-molecular-combination-of-zinc-ii-phthalocyanine-and-tamoxifen-derivative-for-dual-targeting-photodynamic-therapy-and-hormone-therapy
#20
Feng-Ling Zhang, Mei-Ru Song, Gan-Kun Yuan, Huan-Nian Ye, Ye Tian, Ming-Dong Huang, Jin-Ping Xue, Zhi-Hong Zhang, Jian-Yong Liu
The combination of photodynamic therapy and other cancer treatment modalities is a promising strategy to enhance therapeutic efficacy and reduce side effects. In this study, a tamoxifen-zinc(II) phthalocyanine conjugate linked by a triethylene glycol chain has been synthesized and characterized. Having tamoxifen as the targeting moiety, the conjugate shows high specific affinity to MCF-7 breast cancer cells overexpressed estrogen receptors (ERs) and tumor tissues, therefore leading to a cytotoxic effect in the dark due to the cytostatic tamoxifen moiety, and a high photocytotoxicity due to the photosensitizing phthalocyanine unit against the MCF-7 cancer cells...
August 10, 2017: Journal of Medicinal Chemistry
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