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https://www.readbyqxmd.com/read/28548970/rinsing-paired-agent-model-rpam-to-quantify-cell-surface-receptor-concentrations-in-topical-staining-applications-of-thick-tissues
#1
Xiaochun Xu, Yu Wang, Jialing Xiang, Jonathan T C Liu, Kenneth M Tichauer
Conventional molecular assessment of tissue through histology, if adapted to fresh thicker samples, has the potential to enhance cancer detection in surgical margins and monitoring of 3D cell culture molecular environments. However, in thicker samples, substantial background staining is common despite repeated rinsing, which can significantly reduce image contrast. Recently, 'paired-agent' methods-which employ co-administration of a control (untargeted) imaging agent-have been applied to thick-sample staining applications to account for background staining...
May 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28546920/ocular-penetration-of-topically-applied-1-tigecycline-in-a-rabbit-model
#2
Yasar Sakarya, Rabia Sakarya, Muammer Ozcimen, Sertan Goktas, Serap Ozcimen, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan, Servet Cetinkaya, Abdulkadir Bukus
AIM: To evaluate ocular penetration of topically applied 1% tigecycline. METHODS: Forty-two New Zealand White rabbits were divided into 3 groups. A 50 µL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15min for 60min (keratitis protocol). Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180min after the last drop. All animals in group 3 were euthanatized...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28545594/early-blockade-of-joint-inflammation-with-a-fatty-acid-amide-hydrolase-inhibitor-decreases-end-stage-osteoarthritis-pain-and-peripheral-neuropathy-in-mice
#3
Jason J McDougall, Milind M Muley, Holly T Philpott, Allison Reid, Eugene Krustev
BACKGROUND: The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH) which renders them physiologically inert. Osteoarthritis (OA) is primarily a degenerative joint disease; however, it can incorporate mild inflammation and peripheral neuropathy. The aim of this study was to determine whether early blockade of FAAH bioactivity could reduce OA-associated inflammation and joint neuropathy...
May 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28545538/providing-online-weight-management-in-primary-care-a-mixed-methods-process-evaluation-of-healthcare-practitioners-experiences-of-using-and-supporting-patients-using-power
#4
Emily Smith, Katherine Bradbury, Lisa Scott, Mary Steele, Paul Little, Lucy Yardley
BACKGROUND: An online weight management intervention (POWeR+) combined with a small amount of primary care healthcare practitioner support is effective in helping patients to lose weight, but little is known about how practitioners interact with the POWeR+ intervention or their experiences of providing support for patients using POWeR+. The aim of this study was to explore practitioners' usage of POWeR+ and their experiences of providing support to patients using POWeR+. METHODS: Set within a randomised controlled trial of POWeR+, practitioners' usage of POWeR+ was automatically captured and a qualitative process analysis was conducted employing semi-structured telephone interviews with practitioners who provided support to patients using POWeR+...
May 25, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28544939/risk-trading-in-flood-management-an-economic-model
#5
Chiung Ting Chang
Although flood management is no longer exclusively a topic of engineering, flood mitigation continues to be associated with hard engineering options. Flood adaptation or the capacity to adapt to flood risk, as well as a demand for internalizing externalities caused by flood risk between regions, complicate flood management activities. Even though integrated river basin management has long been recommended to resolve the above issues, it has proven difficult to apply widely, and sometimes even to bring into existence...
May 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28543662/inclusion-access-and-civility-in-public-bioethics
#6
Rebecca Dresser
I could tell many war stories about my experience serving on the President's Council on Bioethics-one of the most controversial national bioethics commissions so far-but I want to focus instead on how the experience influenced my views on bioethics, politics, and the potential contributions of national commissions. The executive order that established the Council directed it to consider policy questions, but it spoke primarily of providing a forum for national discussion, inquiry, and education. In this sense, the Council's mission departed from that of other national bioethics commissions, which have had more direct policy functions...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543517/intermediate-and-advanced-topics-in-multilevel-logistic-regression-analysis
#7
Peter C Austin, Juan Merlo
Multilevel data occur frequently in health services, population and public health, and epidemiologic research. In such research, binary outcomes are common. Multilevel logistic regression models allow one to account for the clustering of subjects within clusters of higher-level units when estimating the effect of subject and cluster characteristics on subject outcomes. A search of the PubMed database demonstrated that the use of multilevel or hierarchical regression models is increasing rapidly. However, our impression is that many analysts simply use multilevel regression models to account for the nuisance of within-cluster homogeneity that is induced by clustering...
May 23, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28542409/voting-contagion-modeling-and-analysis-of-a-century-of-u-s-presidential-elections
#8
Dan Braha, Marcus A M de Aguiar
Social influence plays an important role in human behavior and decisions. Sources of influence can be divided as external, which are independent of social context, or as originating from peers, such as family and friends. An important question is how to disentangle the social contagion by peers from external influences. While a variety of experimental and observational studies provided insight into this problem, identifying the extent of contagion based on large-scale observational data with an unknown network structure remains largely unexplored...
2017: PloS One
https://www.readbyqxmd.com/read/28541260/combination-steroid-and-test-based-food-elimination-for-eosinophilic-esophagitis-a-retrospective-analysis
#9
Gregory Constantine, Neha Seth, Niti Chokshi, Charles G Minard, Danielle Guffey, Anthony P Olive, Carla M Davis
OBJECTIVES: Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized by infiltration of eosinophils into the esophagus. Primary treatment approaches include topical corticosteroids and/or food elimination. The aim of the present study was to compare the effectiveness of combination therapy (topical corticosteroid plus test-based food elimination [FS]) with single therapy (topical corticosteroid [S] or test-based food elimination [F]). METHODS: Chart review of patients with EoE at Texas Children's Hospital (age <21 years) was performed...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28540463/investigating-the-organic-and-conventional-production-type-of-olive-oil-with-target-and-suspect-screening-by-lc-qtof-ms-a-novel-semi-quantification-method-using-chemical-similarity-and-advanced-chemometrics
#10
Natasa P Kalogiouri, Reza Aalizadeh, Nikolaos S Thomaidis
The discrimination of organic and conventional production has been a critical topic of public discussion and constitutes a scientific issue. It remains a challenge to establish a correlation between the agronomical practices and their effects on the composition of olive oils, especially the phenolic composition, since it defines their organoleptic and nutritional value. Thus, a liquid chromatography-electrospray ionization-quadrupole time of flight tandem mass spectrometric method was developed, using target and suspect screening workflows, coupled with advanced chemometrics for the identification of phenolic compounds and the discrimination between organic and conventional extra virgin olive oils...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28539710/anti-inflammatory-effects-of-kotmin13-a-mixed-herbal-medicine-in-lps-stimulated-raw-264-7-cells-and-mouse-edema-models
#11
Eujin Lee, Sun-Gun Kim, Na-Young Park, Hyo-Hyun Park, Kyu-Tae Jeong, Jongkeun Choi, In-Hae Lee, Hwadong Lee, Eunkyung Lee
BACKGROUND: A Korean herbal medicine, KOTMIN13, composed of Inula japonica Thunberg, Trichosanthes kirilowii Maximowicz var. japonica kitamura, Peucedanum praeruptorum Dunn, and Allium macrostemon Bge, has been used for anti-allergic and anti-asthmatic treatment in oriental clinics, but its activity has not been investigated. MATERIALS AND METHODS: To evaluate the anti-inflammatory activity of KOTMIN13 for in vitro study, LPS-stimulated RAW 264.7 cells were used to induce the production and expression of inflammatory mediators and its mechanisms...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539706/multiple-immunosuppressive-effects-of-cpg-c41-on-intracellular-tlr-mediated-inflammation
#12
Wancheng Liu, Xuejiao Yang, Ning Wang, Shijun Fan, Yuanfeng Zhu, Xinchuan Zheng, Yan Li
A growing body of literature suggests that most chronic autoimmune diseases are associated with inappropriate inflammation mediated by Toll-like receptor (TLR) 3, TLR7/8, or TLR9. Therefore, research into blocking TLR activation to treat these disorders has become a hot topic. Here, we report the immunomodulatory properties of a nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as a TLR9 antagonist. In this study, we found that both in vitro and in vivo CpG-c41 decreased levels of various proinflammatory factors that were induced by single activation or coactivation of intracellular TLRs, but not membrane-bound TLRs, no matter what downstream signal pathways the TLRs depend on...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28537857/cost-effectiveness-analysis-of-using-dermatologists-versus-pediatricians-to-treat-mild-to-moderate-acne
#13
Scott A Davis, Sebastian Himmler, Steven R Feldman
OBJECTIVE: To assess the cost-effectiveness from the payer perspective of using dermatologists versus pediatricians to treat acne in adolescents ages 10-18. METHODS: A Markov model was constructed to explore outcomes over a 2-year period from the US private payer perspective. Patients ages 10-18 with acne entered the model under the "dermatologist"and "pediatrician" conditions. In each 3-month cycle,each modeled patient received topical retinoids,benzoyl peroxide (BP), antibiotics, or no treatment,and could progress to an acne-free state or remain in an acne state...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28537762/creation-of-an-integrated-knowledge-translation-process-to-improve-pediatric-emergency-care-in-canada
#14
Robin M Featherstone, Carly Leggett, Lisa Knisley, Mona Jabbour, Terry P Klassen, Shannon D Scott, Greg Van De Mosselaer, Lisa Hartling
TREKK (Translating Emergency Knowledge for Kids) was established to address knowledge needs to support care of children in general emergency departments. To achieve this goal, we developed an integrated knowledge translation (KT) process based on identified priorities to create the TREKK Evidence Repository, containing "knowledge pyramids" and Bottom Line Recommendations (summary documents) on the diagnosis and treatment of emergency pediatric conditions. The objective of this article is to describe our methods for developing and disseminating the TREKK Evidence Repository to improve pediatric emergency care in Canada...
May 24, 2017: Health Communication
https://www.readbyqxmd.com/read/28537344/evaluation-of-the-topic-lists-used-in-two-world-congresses-2015-and-2016-in-physical-and-rehabilitation-medicine
#15
Boya Nugraha, Tatjana Paternostro-Sluga, Othmar Schuhfried, Gerold Stucki, Franco Franchignoni, Lydia Abdul Latif, Julia Patrick Engkasan, Zaliha Omar, Christoph Gutenbrunner
BACKGROUND: Evaluation of the initial list of proposed abstract topics for Congresses of Physical and Rehabilitation Medicine (PRM) was needed in order to ensure its feasibility for use in future congress announcements and invitations for abstract submission. METHODS: The initial proposals were based on 5 main areas of PRM research: biosciences in rehabilitation, biomedical rehabilitation sciences and engineering, clinical PRM sciences, integrative rehabilitation sciences, and human functioning sciences...
May 24, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28534395/hyaluronic-acid-templated-ag-nanoparticles-graphene-oxide-composites-for-synergistic-therapy-of-bacteria-infection
#16
Xiang Ran, Ye Du, Zhenzhen Wang, Huan Wang, Fang Pu, Jinsong Ren, Xiaogang Qu
Developing methods of decreasing the harm to cell and increasing the antibacterial efficiency is becoming a potential topic to medical treatments. We demonstrated a hyaluronidase-triggered photothermal platform for killing bacteria based on AgNPs and graphene oxide (GO). The property of the HAase-triggered release provided excellent antibacterial activity against S. aureus. Upon illumination of NIR light, the GO-based nanomaterials locally raised the temperature, resulting in high mortality of bacterial. The HAase-triggered AgNPs releasing approach for antibacterial allows AgNPs to be protected by HA template without affecting mammalian cells...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534261/the-role-of-drug-metabolites-in-the-inhibition-of-cytochrome-p450-enzymes
#17
Momir Mikov, Maja Đanić, Nebojša Pavlović, Bojan Stanimirov, Svetlana Goločorbin-Kon, Karmen Stankov, Hani Al-Salami
Following the drug administration, patients are exposed not only to the parent drug itself, but also to the metabolites generated by drug-metabolizing enzymes. The role of drug metabolites in cytochrome P450 (CYP) inhibition and subsequent drug-drug interactions (DDIs) have recently become a topic of considerable interest and scientific debate. The list of metabolites that were found to significantly contribute to clinically relevant DDIs is constantly being expanded and reported in the literature. New strategies have been developed for better understanding how different metabolites of a drug candidate contribute to its pharmacokinetic properties and pharmacological as well as its toxicological effects...
May 22, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28533570/awareness-and-observance-of-patient-rights-from-the-perspective-of-iranian-patients-a-systematic-review-and-meta-analysis
#18
REVIEW
Ghassem Abedi, Jalil Shojaee, Mahmood Moosazadeh, Farideh Rostami, Aliasghar Nadi, Ehsan Abedini, Charles John Palenik, Mehrdad Askarian
BACKGROUND: Recipients of healthcare services have rights, which must be acknowledged and protected. Such rights include observance of acceptable patient physical, mental, spiritual, and social needs guided by commonly accepted rules and regulations. The objective of this study was to conduct a systematic review and meta-analysis of awareness rates and observance of patient rights in Iran from the perspective of the patient. METHODS: In this study, various references such as Medline (PubMed), Scopus, Scientific Information Database (SID), Google scholar, Magiran, and IranMedex were searched (from August to December 2015)...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28532687/the-role-of-systemic-and-topical-fatty-acids-for-dry-eye-treatment
#19
REVIEW
Stefano Barabino, Jutta Horwath-Winter, Elisabeth M Messmer, Maurizio Rolando, Pasquale Aragona, Shigeru Kinoshita
Dry eye is a prevalent condition and one of the main reasons for patients to seek ophthalmic medical care. A low systemic level of omega fatty acids is a risk factor for dry eye disease (DED). There are two groups of essential fatty acids (EFAs): the omega-6 (n-6) family and the omega-3 (n-3) family. Humans evolved on a diet in which the n-6:n-3 ratio was approximately 1:1, however the current Western diet tends to be deficient in n-3 EFAs and this ratio is typically much higher (approaching 17:1). The metabolism of EFAs generates four new families of local acting mediators: lipoxins, resolvins, protectins, and maresins...
May 19, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28531355/flexible-multiferroic-bulk-heterojunction-with-giant-magnetoelectric-coupling-via-the-van-der-waals-epitaxy
#20
Ying-Hao Chu, Tahta Amrillah, Yugandhar Bitla, Kwangwoo Shin, Tiannan Yang, Ying-Hui Hsieh, Yu-You Chiou, Heng-Jui Liu, Thi Hien Do, Dong Su, Yi-Chun Chen, Shien-Uang Jen, Long-Qing Chen, Kee Hoon Kim, Jenh-Yih Juang
Magnetoelectric nanocomposites have been a topic of intense research due to their profound potential in the applications of electronic devices based on the spintronic technology. Nevertheless, in spite of significant progress made in the growth of high-quality nanocomposite thin films, the substrate clamping effect still remains as a major hurdle in realizing the ultimate magnetoelectric coupling. To overcome this obstacle, an alternative strategy of fabricating self-assembled ferroelectric-ferrimagnetic bulk heterojunction on flexible muscovite via the van der Waals epitaxy is adopted...
May 22, 2017: ACS Nano
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