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https://www.readbyqxmd.com/read/29775083/comparing-efficacy-of-enteral-nutrition-plus-ranitidine-and-enteral-nutrition-alone-as-stress-ulcer-prophylaxis
#1
Anahid Nourian, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Mohammad Taher, Zohreh Dadvar, Masoume Malekolkottab, Masoud Ramezani, Hossein Khalili
AIM: Adequacy of enteral nutrition (EN) alone as stress ulcer prophylaxis (SUP) is controversial. The aim of this study was to compare efficacy of EN alone and ranitidine plus EN as SUP. METHOD: Critically ill adults with indications to receive SUP were randomized to ranitidine 50 mg IV every 8 h plus EN (SUP) or EN alone (non-SUP) group for 7 days. Besides, endoscopy was performed at the time of recruitment and on day 7. RESULTS: During the study period, only one patient in each group of SUP and non-SUP experienced gastrointestinal bleeding...
May 18, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29766305/evaluation-of-vte-prophylaxis-and-the-impact-of-alternate-regimens-on-post-operative-bleeding-and-thrombotic-complications-following-bariatric-procedures
#2
Maria S Altieri, Jie Yang, Janos Hajagos, Konstantinos Spaniolas, Jihye Park, Antonios P Gasparis, Andrew T Bates, Salvatore Docimo, Mark Talamini, A Laurie Shroyer, Aurora D Pryor
BACKGROUND: Studies examining utilization and impact of venous thromboembolism (VTE) chemoprophylaxis for patients undergoing bariatric surgery are limited. Determination of the optimal prophylactic regimen to minimize complications is crucial. METHODS: The Cerner Health Facts database from 2003 to 2013 was queried using ICD-9 codes to identify patients undergoing laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB). VTE chemoprophylaxis regimens were divided into pre-operative alone (PreP), post-operative alone (PostP), both pre-operative and post-operative (PPP), or no prophylaxis (NP)...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29758336/grand-rounds-hepatic-manifestations-of-telomere-biology-disorders
#3
REVIEW
Mrinal M Patnaik, Patrick S Kamath, Douglas A Simonetto
Clinical Case A 51 year old Caucasian male was referred for evaluation of variceal bleeding. Laboratory tests were remarkable for mild thrombocytopenia and moderate alkaline phosphatase elevation. Synthetic liver function was well preserved. Abdominal computed tomography scan revealed moderate splenomegaly, gastric varices, and normal hepatic contour. A transjugular liver biopsy was performed revealing findings of nodular regenerative hyperplasia (NRH) with no significant fibrosis or necroinflammatory activity...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29758192/gastric-mucosal-metastasis-of-prostate-cancer
#4
Hayretdin Koklu, Gokhan Gedikoglu, Taylan Kav
A 65-year-old male patient who had been hospitalized in the ıntensive care unit for pneumonia presented with hematemesis and melena. He was diagnosed with metastatic adenocarcinoma of prostate (multiple bone and lung metastases), which was accompanied by diabetes mellitus, hypertension, and coronary heart disease. The hemoglobin levels decreased from 11.4 g/dL to 7.3 g/dL during follow-up. Upper endoscopy revealed widespread distribution of numerous umbilicated nodules with varying sizes (from 0.5 to 2 cm) on gastric mucosa (A, B, C)...
May 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29757147/analysis-of-weight-changes-after-left-gastric-artery-embolization-in-a-cancer-naive-population
#5
David J Kim, Hari S Raman, Amber Salter, Raja Ramaswamy, Andrew J Gunn, Clifford R Weiss, Olaguoke Akinwande
PURPOSE: We aimed to evaluate weight changes after left gastric artery (LGA) embolization in a retrospective cancer-naive cohort. METHODS: A retrospective study was conducted to identify patients who underwent LGA embolization for gastrointestinal bleeding (GI). Patients with known cancer diagnoses at the time of LGA embolization were excluded. Pre- and postprocedure weights were assessed. Statistical analysis was performed using paired t-test and Wilcoxon signed-rank test...
March 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29743802/upper-gastrointestinal-bleed-due-to-invasive-hepatocellular-carcinoma-and-hepato-gastric-fistula
#6
Abhijith Bale, Shiran Shetty, Anurag Shetty, Girisha Balaraju, Cannanore Ganesh Pai
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743455/-evaluation-of-the-safety-and-efficacy-of-endoscopic-treatment-for-early-gastric-cancers-in-patients-aged-over-80-years
#7
Takeshi Setoyama, Shin' Ichi Miyamoto, Mitsuhiro Nikaido, Takahiro Horimatsu, Shigemi Matsumoto, Yasumasa Ezoe, Shuko Morita, Ikuo Aoyama, Chiharu Kawanami, Toshihiro Kusaka, Tsutomu Chiba, Manabu Muto, Hiroshi Seno
Endoscopic treatments, including endoscopic mucosal resection or endoscopic submucosal dissection, are well accepted as standard treatments for early gastric cancers. However, there are few studies evaluating the safety and efficacy of this approach for early gastric cancers in patients aged over 80 years, and the post-treatment prognosis remains unclear. Here, we retrospectively analyzed the medical records and evaluated the safety and efficacy of endoscopic treatment for early gastric cancers in patients aged over 80 years (group A) compared with non-elderly patients aged 65-79 years (group B) and under 65 years (group C)...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29737316/perioperative-complications-of-sleeve-gastrectomy-review-of-the-literature
#8
REVIEW
Antonio Iannelli, Patrick Treacy, Lionel Sebastianelli, Luigi Schiavo, Francesco Martini
Sleeve gastrectomy (SG) has known a spectacular rise worldwide during the last decade. The absence of digestive anastomosis simplifies the surgical technique, reducing anastomosis-related complications such as fistula, stricture and marginal ulcer. Furthermore, the respect for digestive continuity preserves the functions of pylorus, that regulates gastric emptying, and duodenum, where calcium, B vitamins and iron are absorbed. Despite the multiple advantages, SG also has specific complications such as bleeding, stenosis, portal thrombosis and leak...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29732226/acute-gastrointestinal-bleeding-in-olmesartan-associated-collagenous-gastroduodenitis-a-potential-endoscopic-complication
#9
Rachel Hudacko, Lance Siegel
Collagenous gastroenteritis is a rare disease that is known to be associated with the drug olmesartan, an angiotensin II receptor antagonist used to treat hypertension. It is characterized histologically by increased subepithelial collagen deposition with associated inflammation and epithelial injury. Endoscopically, the mucosa appears inflamed and friable and may be nodular or atrophic. We report a case of acute gastric bleeding on direct mucosal contact during endoscopy in a patient with olmesartan-associated collagenous gastroduodenitis to raise awareness of this potential endoscopic complication...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29732154/unusual-growth-of-an-epstein-barr-virus-associated-differentiated-early-stage-gastric-carcinoma-a-case-report
#10
Noriyuki Horiguchi, Tomomitsu Tahara, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Naoko Nakano, Yoshihito Nakagawa, Mitsuo Nagasaka, Mitsuru Nakagawa, Tetsuya Tsukamoto, Tomoyuki Shibata, Naoki Ohmiya
Epstein-Barr virus (EBV) infection is involved in a subset of gastric carcinoma (GC) cases, and is associated with distinct clinicopathological features. The present study reports a unique case of EBV-associated early-stage GC compared with the other cases experienced in our hospital. A 72-year-old male receiving treatment for cerebral infarction underwent an esophagogastroduodenoscopy (EGD) for suspicion of gastrointestinal bleeding. EGD revealed a type 0-I protruding lesion in the lesser curvature of the upper gastric corpus...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29730601/early-application-of-haemostatic-powder-added-to-standard-management-for-oesophagogastric-variceal-bleeding-a-randomised-trial
#11
Mostafa Ibrahim, Ahmed El-Mikkawy, Mohamed Abdel Hamid, Haitham Abdalla, Arnaud Lemmers, Ibrahim Mostafa, Jacques Devière
BACKGROUND: Acute variceal bleeding (AVB) requires early therapeutic management by experienced endoscopists that often poses logistical challenges for hospitals. We assessed a different management concept with early application of haemostatic powder-which does not require high endoscopic expertise-added to conventional management in a randomised trial. METHODS: Cirrhotic patients with AVB received standard medical therapy and were randomised to either immediate endoscopy with haemostatic powder application within 2 hours of admission, followed by early elective endoscopy on the next day, that is, within 12-24 hours of admission for definitive treatment (study group) or to early elective endoscopy only (control group)...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29725977/gastrosplenic-fistula-with-gastrointestinal-bleeding-a-rare-and-potentially-fatal-complication-after-sleeve-gastrectomy
#12
Laura Montana, Laurent Genser, Alexandre Cortes, Eric Poupardin, Christophe Barrat, Sergio Carandina
BACKGROUND: Although the surgical technique is safe and standardized, laparoscopic sleeve gastrectomy (LSG) is associated with serious and potentially life-threatening complications, such as gastric leak and bleeding. METHODS: In this retrospective study, three French university hospitals reviewed their experience with LSG. Between September 2014 and May 2016, three cases of gastrosplenic fistula complicated by massive upper gastrointestinal hemorrhage (UGIH) were recorded...
May 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29725533/ulcerated-gastric-leiomyoma-causing-massive-upper-gastrointestinal-bleeding-a-case-report
#13
Daryl Ramai, Qiuxue T Tan, Sofia Nigar, Emmanuel Ofori, Denzil Etienne, Madhavi Reddy
Leiomyomas are rare, benign submucosal tumors originating from smooth muscle cells. The clinical presentation is usually asymptomatic, with excellent prognosis. We herein report the case of a 68-year-old female with a solitary leiomyoma found during esophagogastroduodenoscopy for hematemesis. Histopathological examination revealed smooth muscle proliferation supported by positive staining for smooth muscle myosin heavy chain and negative staining for CD117 and S-100, consistent with the marker expression pattern of leiomyoma...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29721346/hsct-gave-as-a-manifestation-of-chronic-graft-versus-host-disease-a-case-report-and-review-of-the-existing-literature
#14
Michael J Grant, Mitchell E Horwitz
Gastric antral vascular ectasia or "watermelon stomach" is a significant cause of nonvariceal upper GI bleeding and is characterized by red, tortuous ectatic vessels along longitudinal folds in the gastric antrum. The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29720867/synchronous-gastric-and-duodenal-metastases-from-head-and-neck-squamous-cell-carcinoma-a-unique-presentation-of-upper-gastrointestinal-bleeding
#15
Nicholas P Tarangelo, C Andrew Kistler, Zachary Daitch, Wei Jiang, Daniel M Quirk
Metastatic disease to the stomach or duodenum is an infrequent diagnosis, and head and neck squamous cell carcinoma (HNSCC) is one of the least common primary malignancies that lead to gastric or duodenal metastases. We report the case of a 65-year-old man with human immunodeficiency virus infection and previously diagnosed HNSCC who presented with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29720860/continued-versus-interrupted-aspirin-use-and-bleeding-risk-after-endoscopic-submucosal-dissection-of-gastric-neoplasms-a-meta-analysis
#16
Veeravich Jaruvongvanich, Tomoki Sempokuya, Karn Wijarnpreecha, Patompong Ungprasert
Background: Balancing the risk of bleeding and thromboembolic events for patients who use aspirin and need to undergo endoscopic submucosal dissection (ESD) for gastric neoplasms is a delicate process. The current guidelines from different associations provide inconsistent recommendations. Methods: MEDLINE and EMBASE databases were searched through August 2017 for studies that compared the risk of post-ESD bleeding in patients who continued aspirin vs. those who discontinued aspirin preoperatively...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29715144/successful-distal-gastrectomy-for-gastric-cancer-with-child-pugh-class-b-alcoholic-liver-cirrhosis
#17
Jun Iwabu, Tsutomu Namikawa, Sachi Tsuda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
Extended lymph node dissection in patients with gastric cancer with liver cirrhosis can lead to severe morbidity and mortality, especially in those with Child-Pugh class B or C cirrhosis. We, herein, report a case of advanced gastric cancer with alcoholic liver cirrhosis that was successfully treated by surgery. A 58-year-old male patient was diagnosed with gastric cancer with alcoholic liver cirrhosis Child-Pugh class B. A red blood cell transfusion was performed to treat cancer-related hemorrhage; however, the patient's hemoglobin level did not improve and distal gastrectomy with D1 lymph node dissection was subsequently performed to prevent further bleeding...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29704739/silastic-band-erosion-in-the-bypassed-stomach-after-fobi-pouch-operation-for-obesity-case-report
#18
A M Franco-Martínez, M Guraieb-Trueba, R Castañeda-Sepúlveda, E A Flores-Villalba, J Rojas-Méndez
INTRODUCTION: Worldwide, one of the most commonly performed bariatric surgeries is the laparoscopic Roux-en-Y gastric bypass (LRYGP). Access to the bypassed stomach in patients who have undergone this procedure, for evaluation and/or management in different clinical situations remains a challenge for the physician. In order to facilitate the entrance to the gastric remnant, a silastic marker is left in place during the Fobi-Pouch operation, a modified laparoscopic gastric bypass surgery technique...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29699526/computerized-tomography-findings-in-calcified-signet-ring-gastric-cancer-receiving-chemotherapy-a-case-report
#19
Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang, Long Huang
BACKGROUND: Calcification in primary gastric cancer is very rare. In this report, we describe the computerized tomography (CT) changes in calcification in a patient with locally advanced signet-ring gastric cancer treated with chemotherapy. CASE PRESENTATION: A 49-year-old man presented with 5 months' history of abdominal pain, anorexia, and rapid weight loss. He had undergone Billroth-II subtotal gastrectomy for a bleeding gastric ulcer 30 years ago. Abdominal CT showed irregular thickening of the gastric wall and miliary calcifications...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29695516/phase-1-study-of-the-pi3k%C3%AE-inhibitor-incb040093-%C3%A2-jak1-inhibitor-itacitinib-in-relapsed-refractory-b-cell-lymphoma
#20
Tycel J Phillips, Andres Forero-Torres, Taimur Sher, Catherine S Diefenbach, Patrick Johnston, Moshe Talpaz, Jennifer Pulini, Li Zhou, Peggy Scherle, Xuejun Chen, Paul M Barr
Because both phosphatidylinositol 3-kinase δ (PI3Kδ) and Janus kinase (JAK)-signal transducer and activator of transcription pathways contribute to tumor cell proliferation and survival in B-cell malignancies, their simultaneous inhibition may provide synergistic treatment efficacy. This phase 1 dose-escalation/expansion study assessed the safety, efficacy, pharmacokinetics, and pharmacodynamics of INCB040093, a selective PI3Kδ inhibitor, as monotherapy or combined with itacitinib (formerly INCB039110), a selective JAK1 inhibitor, in adult patients with relapsed or refractory (R/R) B-cell lymphomas...
April 25, 2018: Blood
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