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Imaging informatics

Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
James M Brown, Neil R Horner, Thomas N Lawson, Tanja Fiegel, Simon Greenaway, Hugh Morgan, Natalie Ring, Luis Santos, Duncan Sneddon, Lydia Teboul, Jennifer Vibert, Gagarine Yaikhom, Henrik Westerberg, Ann-Marie Mallon
High-throughput phenotyping is a cornerstone of numerous functional genomics projects. In recent years, imaging screens have become increasingly important in understanding gene-phenotype relationships in studies of cells, tissues and whole organisms. Three-dimensional (3D) imaging has risen to prominence in the field of developmental biology for its ability to capture whole embryo morphology and gene expression, as exemplified by the International Mouse Phenotyping Consortium (IMPC). Large volumes of image data are being acquired by multiple institutions around the world that encompass a range of modalities, proprietary software and metadata...
October 14, 2016: Briefings in Bioinformatics
Benoit Aigouy, Daiki Umetsu, Suzanne Eaton
Epithelia are tissues that regulate exchanges with the environment. They are very dynamic and can acquire virtually any shape; at the cellular level, they are composed of cells tightly connected by junctions. Most often epithelia are amenable to live imaging; however, the large number of cells composing an epithelium and the absence of informatics tools dedicated to epithelial analysis largely prevented tissue scale studies. Here we present Tissue Analyzer, a free tool that can be used to segment and analyze epithelial cells and monitor tissue dynamics...
2016: Methods in Molecular Biology
Xiao-Ying Zhang, Peiying Zhang
The telemedicine department of a hospital is an emerging branch in upcoming hospitals and may become an essential component of every hospital. It basically utilizes the information technologies along with telecommunication systems in order to provide clinical care and assistance. Furthermore, the branch of telemedicine offers significant opportunities for the process of developmental freedom from illness, early death, and preventable diseases. It advances development by providing relevant drugs and the necessary care aimed to alleviate patient suffering...
October 2016: Experimental and Therapeutic Medicine
Myles Fennell, Kaylene J Simpson
No abstract text is available yet for this article.
October 2016: Assay and Drug Development Technologies
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Anticancer Research
Joseph J Shaffer, Michael J Peterson, Mary Agnes McMahon, Joshua Bizzell, Vince Calhoun, Theo G M van Erp, Judith M Ford, John Lauriello, Kelvin O Lim, Dara S Manoach, Sarah C McEwen, Daniel H Mathalon, Daniel O'Leary, Steven G Potkin, Adrian Preda, Jessica Turner, Jim Voyvodic, Cynthia G Wible, Aysenil Belger
BACKGROUND: The negative symptoms of schizophrenia include deficits in emotional expression and motivation. These deficits are stable over the course of illness and respond poorly to current medications. Previous studies have focused on negative symptoms as a single category; however, individual symptoms might be related to separate neurological disturbances. We analyzed data from the Functional Biomedical Informatics Research Network dataset to explore the relationship between individual negative symptoms and functional brain activity during an auditory oddball task...
December 2015: Molecular Neuropsychiatry
Sergey M Plis, Anand D Sarwate, Dylan Wood, Christopher Dieringer, Drew Landis, Cory Reed, Sandeep R Panta, Jessica A Turner, Jody M Shoemaker, Kim W Carter, Paul Thompson, Kent Hutchison, Vince D Calhoun
The field of neuroimaging has embraced the need for sharing and collaboration. Data sharing mandates from public funding agencies and major journal publishers have spurred the development of data repositories and neuroinformatics consortia. However, efficient and effective data sharing still faces several hurdles. For example, open data sharing is on the rise but is not suitable for sensitive data that are not easily shared, such as genetics. Current approaches can be cumbersome (such as negotiating multiple data sharing agreements)...
2016: Frontiers in Neuroscience
J Peter Campbell, Jayashree Kalpathy-Cramer, Deniz Erdogmus, Peng Tian, Dharanish Kedarisetti, Chace Moleta, James D Reynolds, Kelly Hutcheson, Michael J Shapiro, Michael X Repka, Philip Ferrone, Kimberly Drenser, Jason Horowitz, Kemal Sonmez, Ryan Swan, Susan Ostmo, Karyn E Jonas, R V Paul Chan, Michael F Chiang
PURPOSE: To identify patterns of interexpert discrepancy in plus disease diagnosis in retinopathy of prematurity (ROP). DESIGN: We developed 2 datasets of clinical images as part of the Imaging and Informatics in ROP study and determined a consensus reference standard diagnosis (RSD) for each image based on 3 independent image graders and the clinical examination results. We recruited 8 expert ROP clinicians to classify these images and compared the distribution of classifications between experts and the RSD...
August 30, 2016: Ophthalmology
Anandika Dhaliwal, Matthew Brenner, Paul Wolujewicz, Zheng Zhang, Yong Mao, Mona Batish, Joachim Kohn, Prabhas V Moghe
: A predictive framework for the evolution of stem cell biology in 3-D is currently lacking. In this study we propose deep image informatics of the nuclear biology of stem cells to elucidate how 3-D biomaterials steer stem cell lineage phenotypes. The approach is based on high content imaging informatics to capture minute variations in the 3-D spatial organization of splicing factor SC-35 in the nucleoplasm as a marker to classify emergent cell phenotypes of human mesenchymal stem cells (hMSCs)...
November 2016: Acta Biomaterialia
Matthias Löbe, Thomas Ganslandt, Lydia Lotzmann, Sebastian Mate, Jan Christoph, Benjamin Baum, Murat Sariyar, Jie Wu, Sebastian Stäubert
Due to the specific needs of biomedical researchers, in-house development of software is widespread. A common problem is to maintain and enhance software after the funded project has ended. Even if many tools are made open source, only a couple of projects manage to attract a user basis large enough to ensure sustainability. Reasons for this include complex installation and configuration of biomedical software as well as an ambiguous terminology of the features provided; all of which make evaluation of software laborious...
2016: Studies in Health Technology and Informatics
Karsten Brandt, Matthias Löbe, Michael Schaaf, Franziska Jahn, Alfred Winter, Sebastian Stäubert
Medical research and health care highly depend on the use of information technology. There is a wide range of application systems (patient administration system, laboratory information system, communication server etc.) and heterogeneous data types (administrative data, clinical data, laboratory data, image data, genomic data etc.). Students and researchers do not often have the possibility to use productive application systems of e.g. hospitals or medical practices to gain practical experiences or examine new components and technologies...
2016: Studies in Health Technology and Informatics
Lorenzo Faggioni, Francesca Coppola, Riccardo Ferrari, Emanuele Neri, Daniele Regge
OBJECTIVES: To assess the opinion on structured reporting (SR) and its usage by radiologist members of the Italian Society of Medical Radiology (SIRM) via an online survey. METHODS: All members received an email invitation to join the survey as an initiative by the SIRM Imaging Informatics Chapter. The survey included 10 questions about demographic information, definition of radiological SR, its usage in everyday practice, perceived advantages and disadvantages over conventional reporting and overall opinion about SR...
August 29, 2016: European Radiology
Sheng Yang, Curtis Tatsuoka, Kaushik Ghosh, Nuria Lacuey-Lecumberri, Samden D Lhatoo, Satya S Sahoo
Recent advances in brain fiber tractography algorithms and diffusion Magnetic Resonance Imaging (MRI) data collection techniques are providing new approaches to study brain white matter connectivity, which play an important role in complex neurological disorders such as epilepsy. Epilepsy affects approximately 50 million persons worldwide and it is often described as a disorder of the cortical network organization. There is growing recognition of the need to better understand the role of brain structural networks in the onset and propagation of seizures in epilepsy using high resolution non-invasive imaging technologies...
2016: AMIA Summits on Translational Science Proceedings
Jayashree Kalpathy-Cramer, J Peter Campbell, Deniz Erdogmus, Peng Tian, Dharanish Kedarisetti, Chace Moleta, James D Reynolds, Kelly Hutcheson, Michael J Shapiro, Michael X Repka, Philip Ferrone, Kimberly Drenser, Jason Horowitz, Kemal Sonmez, Ryan Swan, Susan Ostmo, Karyn E Jonas, R V Paul Chan, Michael F Chiang
PURPOSE: To determine expert agreement on relative retinopathy of prematurity (ROP) disease severity and whether computer-based image analysis can model relative disease severity, and to propose consideration of a more continuous severity score for ROP. DESIGN: We developed 2 databases of clinical images of varying disease severity (100 images and 34 images) as part of the Imaging and Informatics in ROP (i-ROP) cohort study and recruited expert physician, nonexpert physician, and nonphysician graders to classify and perform pairwise comparisons on both databases...
August 24, 2016: Ophthalmology
James Whitfill
No abstract text is available yet for this article.
October 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Kang Xiao, Wenrui Zhao, Liying Zhou, Donald Choy Chang
A critical process in apoptosis is the permeabilization of the mitochondrial outer membrane (MOM). This process is known to be regulated by the multi-domain Bcl-2 family proteins. For example, the pro-apoptotic proteins Bax and Bak are responsible for forming pores at MOM. The anti-apoptotic proteins (including Bcl-2, Mcl-1 and Bcl-xL), on the other hand, can inhibit this pore-forming process. Interestingly, although these two subgroups of proteins perform opposite apoptotic functions, their structures are very similar...
November 2016: Apoptosis: An International Journal on Programmed Cell Death
Myles Fennell, Kaylene J Simpson
No abstract text is available yet for this article.
September 2016: Assay and Drug Development Technologies
Kwangsik Nho, Emrin Horgusluoglu, Sungeun Kim, Shannon L Risacher, Dokyoon Kim, Tatiana Foroud, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Robert C Green, Arthur W Toga, Andrew J Saykin
BACKGROUND: Pathogenic mutations in PSEN1 are known to cause familial early-onset Alzheimer's disease (EOAD) but common variants in PSEN1 have not been found to strongly influence late-onset AD (LOAD). The association of rare variants in PSEN1 with LOAD-related endophenotypes has received little attention. In this study, we performed a rare variant association analysis of PSEN1 with quantitative biomarkers of LOAD using whole genome sequencing (WGS) by integrating bioinformatics and imaging informatics...
2016: BMC Medical Genomics
Sonal Kothari, Hang Wu, Li Tong, Kevin E Woods, May D Wang
Biomedical in vivo imaging has been playing an essential role in diagnoses and treatment in modern medicine. However, compared with the fast development of medical imaging systems, the medical imaging informatics, especially automated prediction, has not been fully explored. In our paper, we compared different feature extraction and classification methods for prediction pipeline to analyze in vivo endomicroscopic images, obtained from patients who are at risks for the development of gastric disease, esophageal adenocarcionoma...
February 2016: ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics
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