Read by QxMD icon Read


Ugochukwu Offor, Ayoola I Jegede, Ismail O Onanuga, Edwin C Naidu, Onyemaechi O Azu
BACKGROUND: Nephrotoxicity has become an important public health problem following the success recorded with highly active antiretroviral therapy and there is paucity of literature reporting the attenuating influence of plant-based adjuvants that can mitigate the effects. METHODS: Sixty three adult male Sprague-Dawley rats were divided into 9 groups (A-I) and treated as follows; Group A received HAART cocktail (Lamivudine, Stavudine & Nevirapine), Group B received HAART and Hypoxis hemerocallidea (HH) extract (200mg/kg), Group C received HAART and HH (100mg/kg), Group D received HAART and vitamin C, Group E received HAART and vitamin E, Group F received HAART, vitamin C and vitamin E, Group G received HH extract (100mg/kg), Group H received HH extract (200mg/kg), and Group I received saline as placebo...
September 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Oluwafemi O Oguntibeju, Samantha Meyer, Yapo G Aboua, Mediline Goboza
Background. Hypoxis hemerocallidea is a native plant that grows in the Southern African regions and is well known for its beneficial medicinal effects in the treatment of diabetes, cancer, and high blood pressure. Aim. This study evaluated the effects of Hypoxis hemerocallidea on oxidative stress biomarkers, hepatic injury, and other selected biomarkers in the liver and kidneys of healthy nondiabetic and streptozotocin- (STZ-) induced diabetic male Wistar rats. Materials and Methods. Rats were injected intraperitoneally with 50 mg/kg of STZ to induce diabetes...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
A I Jegede, U Offor, I O Onanuga, E C S Naidu, O O Azu
Although the successful introduction and rollout of antiretroviral therapy has impacted positively on morbidity and mortality of HIV-positive patients, its interaction with plant-based adjuvants remain sparsely investigated. We report the interaction and effects of adjuvant treatment with highly active antiretroviral therapy (HAART) and Hypoxis hemeocallidea (HH) extracts on testicular structure of rats. A total of 63 pathogen-free adult male Sprague Dawley rats were divided into nine groups and treated according to protocols...
July 12, 2016: Andrologia
A Okem, M Moyo, W A Stirk, J F Finnie, J Van Staden
Hypoxis hemerocallidea is a highly utilized medicinal plant in South Africa. Its cultivation has received considerable attention in order to meet the high demand. High levels of cadmium (Cd) and aluminum (Al) in H. hemerocallidea plants sold in traditional medicinal markets was previously reported. The present study used an in vitro propagation model to investigate the uptake of Cd and Al by H. hemerocallidea and their effect on plant growth, elemental uptake and some stress-induced responses such as pigment, malondialdehyde (MDA), proline content and ultrastructural changes...
September 2016: Plant Biology
Ayşegül Doğan Demir, Nilufer Goknar, Faruk Oktem, Emin Özkaya, Mebrure Yazıcı, Emel Torun, Aysel Vehapoğlu, Mehmet Kucukkoc
BACKGROUND: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. OBJECTIVES: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. METHODS: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects...
June 7, 2016: International Journal of Immunopathology and Pharmacology
Mikhail Yu Martynov, Eugeny I Gusev
Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow by thrombolysis or mechanical thrombus extraction during the first few hours of ischemic stroke, which is one of the most effective treatments and leads to a better functional and clinical outcome. The other direction of treatment, which is potentially applicable to most of the patients with ischemic stroke, is neuroprotection...
2015: Journal of Experimental Pharmacology
Aryeh Keehn, Jacob Taylor, Franklin C Lowe
INTRODUCTION: The use of complementary and alternative medications for symptomatic benign prostatic hyperplasia is a lucrative business in the USA with revenues reaching close to US$6.4 billion in sales for the 2014 fiscal year. Yet, despite its popularity, the evidence supporting the continued use of phytotherapy for symptomatic benign prostatic hyperplasia (BPH) is questionable and a topic worth investigation given its wide spread use. METHODS: A comprehensive literature search utilizing Medline and PubMed was conducted to identify literature pertaining to phytotherapy for the management of BPH...
July 2016: Current Urology Reports
M Xu, Y Zhang, L Tang, H Huang
This study aims to investigate serum concentration of hypoxia inducible factor-1α; (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with aneurysms at different stages, and to determine critical role in early diagnosis and evaluation of severity. A cohort of 102 cases of patients diagnosed as aneurysms during May 2012 to April 2015 in our hospital were retrospectively analyzed. Patients were divided into early stage group (n=32), mid-term group (n=34), and late stage group (n=36) according to severity of aneurysms...
2016: Cellular and Molecular Biology
Anna Surtel, Robert Klepacz, Joanna Wysokińska-Miszczuk
Nose breathing is one of the key factors in the proper development and functioning of the oral cavity. The air passing through the nasal cavity is warmed and humidified while dust and other particulate matter is removed. It is also important as far as bone formation is concerned. The obstruction or congestions of the upper respiratory tract may negatively affect the correct and most optimal (nasal) respiratory tract. The switch from nasal to mouth breathing may lead to serious clinical consequences. Children with the clinical diagnosis of mouth breathing are usually pale, apathetic and they lack concentration and often get tired...
December 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Bianca Tamires Silva Dos Santos, Valeria Juliete Da Silva, Jose Antonio Marin Fernandes
Edessa is comprised of six subgenera, Aceratodes, Ascra, Dorypleura, Edessa, Hypoxys and Pygoda. Ascra is here elevated to genus status based on characteristics of the male and female genitalia and the gibbous pronotum. This genus is comprised of eight species previously placed in Edessa-E. bifida, E. cordifera, E. petersii, E. abdita, E. championi, E. privata, E. conspersa and E. morbosa, as well as six new species. The genus Ascra was further divided into two groups of species bifida and privata separated by a different pattern of punctuation on body and pygophore...
2015: Zootaxa
Pius S Fasinu, Bill J Gurley, Larry A Walker
For healthcare professionals, the volume of literature available on herb-drug interactions often makes it difficult to separate experimental/potential interactions from those deemed clinically relevant. There is a need for concise and conclusive information to guide pharmacotherapy in HIV/AIDS. In this review, the bases for potential interaction of medicinal herbs with specific antiretroviral drugs are presented, and several botanicals are discussed for which clinically relevant interactions in humans are established...
2015: Current Drug Metabolism
B-E Van Wyk
ETHNOPHARMACOLOGICAL RELEVANCE: Data on the relative importance and research status of commercially relevant African medicinal plants are needed for developing new research strategies in order to stimulate much-needed ethnopharmacological research and to promote the commercialization of African plants. AIM OF THE STUDY: To present an illustrated bird's eye view and comparative analysis of the relative popularity and importance of commercialized African medicinal plants...
December 24, 2015: Journal of Ethnopharmacology
Ambrose Okem, Wendy A Stirk, Renée A Street, Colin Southway, Jeffrey F Finnie, Johannes Van Staden
This study investigated the effects of cadmium (Cd) and aluminium (Al) on the accumulation of phenolics, flavonoids and the bioactive compound hypoxoside in Hypoxis hemerocallidea. In addition, antioxidant scavenging and antibacterial activity were assessed to evaluate if Cd and Al stress affect the accumulation of bioactive compounds in H. hemerocallidea. In vitro grown plantlets of H. hemerocallidea were acclimatized for seven months in a greenhouse. Thereafter plants were exposed to various concentrations of Cd and Al both singularly and in combination in the form of Cd(NO3)2 (2, 5, 10 mg Cd/L); Al3(NO3)3 (500, 1000, 1500 mg Al/L) and combinations of Cd and Al (Cd 2:Al 500, Cd 5:Al 1000 and Cd 10:Al 1500 mg/L) for a further six weeks...
December 2015: Plant Physiology and Biochemistry: PPB
Tevfik Kaplan, Perihan Ekmekçi, Baturay Kansu Kazbek, Nalan Ogan, Aslıhan Alhan, Bulent Koçer, Serdar Han, Filiz Tüzüner
AIM: This study was undertaken to compare the clinical performance of right versus left double-lumen endotracheal tubes placed without using fiberoptic bronchoscopy in thoracic surgery operations. METHODS: This was a retrospective review of patients who were operated on in our institution between January 2013 and February 2014. We analyzed clinical performance in terms of hypoxia, hypercapnia, and adequate deflation of the lungs with both left- and right-sided double-lumen endotracheal tubes...
September 2015: Asian Cardiovascular & Thoracic Annals
Hughes Gail, Blouws Tarryn, Aboyade Oluwaseyi, Davids Denver, Mbamalu Oluchi, Van't Klooster Charlotte, De Jong Joop, Gibson Diana
ETHNOPHARMACOLOGICAL RELEVANCE: The aim of the study was to identify and document plants traditionally used to manage HIV and treat its opportunistic infections (OIs) in Mpoza, a rural village located in the Mount Frere Alfred Nzo District, Eastern Cape Province, South Africa. MATERIALS AND METHODS: Semi-structured interviews and focus group discussions (FGDs) were conducted with 18 traditional health practitioners from January 2012 to August 2012 to obtain information about medicinal plants used in the management of HIV and treatment of OIs...
August 2, 2015: Journal of Ethnopharmacology
Heling Zhou, Rami R Hallac, Ramona Lopez, Rebecca Denney, Matthew T MacDonough, Li Li, Li Liu, Edward E Graves, Mary Lynn Trawick, Kevin G Pinney, Ralph P Mason
Vascular disrupting agents (VDAs) have been proposed as an effective broad spectrum approach to cancer therapy, by inducing ischemia leading to hypoxia and cell death. A novel VDA (OXi8007) was recently reported to show rapid acute selective shutdown of tumor vasculature based on color-Doppler ultrasound. We have now expanded investigations to noninvasively assess perfusion and hypoxiation of orthotopic human MDA-MB-231/luc breast tumor xenografts following the administration of OXi8007 based on dynamic bioluminescence imaging (BLI) and magnetic resonance imaging (MRI)...
2015: American Journal of Nuclear Medicine and Molecular Imaging
Lerato Seleteng Kose, Annah Moteetee, Sandy Van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. Therefore, there are gaps in the documentation of medicinal plants used in Lesotho. AIM OF THE STUDY: The purpose of the current study is to investigate common ailments in Lesotho's traditional medicine and document plants that are used in treating such ailments...
July 21, 2015: Journal of Ethnopharmacology
M Rouers, P Truntzer, S Dubourg, S Guihard, D Antoni, G Noël
In France, in 2005, there were approximately 16,000 new cases of head and neck cancer. These cancers have an unfavourable prognosis: the survival rates at 3 and 10 years are 50% and 10% respectively. The consumption of alcohol and tobacco is the most important risk factor; in some countries HPV infection was identified as a risk factor of head and neck tumours. Furthermore, a poor oral hygiene seems to raise this risk. We found many decay and periodontium problems in patients with an upper aerodigestive tract cancer...
May 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Shakira Shaik, Kesigan Govender, Moeketsi Leanya
BACKGROUND: Hypoxis hemerocallidea, arguably the most well-known medicinal species in South Africa, has been the subject of intensive harvesting from the wild leading to recent conservation concerns. The seeds of this species do not propagate easily and can lie dormant for up to twelve months. MATERIALS AND METHODS: In the in vitro germination experiments water, acid and chemical pre-sowing treatments were performed to determine the germination response of this species in both light and dark conditions...
2014: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Anthony J Afolayan, Gloria A Otunola
BACKGROUND: Herbal medicine is a popular means of medical management in some parts of the world especially in Africa. Hypoxis hemerocallidea Fisch.C.A.Mey. & Avé-Lall, also known as African potato of the Hypoxidaecae family, is one of the medicinal plants that have enjoyed long usage as an herbal medicine in South Africa. In this study, the morphology and elemental constituents of H. hemerocallidea leaf was investigated to correlate the functional role of the ultrastructure in the production of therapeutic compounds...
2014: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"