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https://www.readbyqxmd.com/read/28447606/a-tunable-high-pass-filter-for-simple-and-inexpensive-size-segregation-of-sub-10-nm-nanoparticles
#1
N C Surawski, S Bezantakos, K Barmpounis, M C Dallaston, A Schmidt-Ott, G Biskos
Recent advanced in the fields of nanotechnology and atmospheric sciences underline the increasing need for sizing sub-10-nm aerosol particles in a simple yet efficient way. In this article, we develop, experimentally test and model the performance of a High-Pass Electrical Mobility Filter (HP-EMF) that can be used for sizing nanoparticles suspended in gaseous media. Experimental measurements of the penetration of nanoparticles having diameters down to ca 1nm through the HP-EMF are compared with predictions by an analytic, a semi-empirical and a numerical model...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28445611/equivalence-of-complex-drug-products-advances-in-and-challenges-for-current-regulatory-frameworks
#2
Leonie Hussaarts, Stefan Mühlebach, Vinod P Shah, Scott McNeil, Gerrit Borchard, Beat Flühmann, Vera Weinstein, Sesha Neervannan, Elwyn Griffiths, Wenlei Jiang, Elena Wolff-Holz, Daan J A Crommelin, Jon S B de Vlieger
Biotechnology and nanotechnology provide a growing number of innovator-driven complex drug products and their copy versions. Biologics exemplify one category of complex drugs, but there are also nonbiological complex drug products, including many nanomedicines, such as iron-carbohydrate complexes, drug-carrying liposomes or emulsions, and glatiramoids. In this white paper, which stems from a 1-day conference at the New York Academy of Sciences, we discuss regulatory frameworks in use worldwide (e.g., the U...
April 26, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28444018/effect-of-nanotechnology-in-self-etch-bonding-systems-on-the-shear-bond-strength-of-stainless-steel-orthodontic-brackets
#3
Shaza M Hammad, Noha El-Wassefy, Ahmed Maher, Shafik M Fawakerji
OBJECTIVE: To evaluate the effect of silica dioxide (SiO2) nanofillers in different bonding systems on shear bond strength (SBS) and mode of failure of orthodontic brackets at two experimental times. METHODS: Ninety-six intact premolars were divided into four groups: A) Conventional acid-etch and primer Transbond XT; B) Transbond Plus self-etch primer; and two self-etch bonding systems reinforced with silica dioxide nanofiller at different concentrations: C) Futurabond DC at 1%; D) Optibond All-in-One at 7%...
February 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28442906/a-review-of-drug-delivery-systems-based-on-nanotechnology-and-green-chemistry-green-nanomedicine
#4
REVIEW
Hossein Jahangirian, Ensieh Ghasemian Lemraski, Thomas J Webster, Roshanak Rafiee-Moghaddam, Yadollah Abdollahi
This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine". Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28441862/spatial-temporal-dispersion-of-aerosolized-nanoparticles-during-the-use-of-consumer-spray-products-and-estimates-of-inhalation-exposure
#5
Jihoon Park, Seunghon Ham, Miyeon Jang, Jinho Lee, Sunju Kim, Sungkyoon Kim, Kiyoung Lee, Donguk Park, Jung-Taek Kwon, Hyunmi Kim, Pilje Kim, Kyunghee Choi, Chungsik Yoon
We evaluated the spatial-temporal dispersion of airborne nanomaterials during the use of spray consumer products and estimated the level of consumer inhalation exposure. A total of eight spray products including five propellant and three pump types were selected to evaluate the dispersion of airborne nanoparticles across time and space in a cleanroom which could control the background particles. Four products were advertised to contain silver and one contained titanium nanoparticles, while three products were specified no ENM but as being manufactured through the use of nanotechnology...
April 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28441776/gold-nanoparticles-for-modulating-neuronal-behavior
#6
REVIEW
Chiara Paviolo, Paul R Stoddart
Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface...
April 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28441713/accelerating-advances-in-science-engineering-and-medicine-through-nanoscience-and-nanotechnology
#7
Warren C W Chan, Ali Khademhosseini, Helmuth Möhwald, Wolfgang J Parak, Jeff F Miller, Aydogan Ozcan, Paul S Weiss
No abstract text is available yet for this article.
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28440368/mangiferin-functionalized-radioactive-gold-nanoparticles-mgf-198-aunps-in-prostate-tumor-therapy-green-nanotechnology-for-production-in-vivo-tumor-retention-and-evaluation-of-therapeutic-efficacy
#8
A Y Al-Yasiri, M Khoobchandani, C S Cutler, L Watkinson, T Carmack, C J Smith, M Kuchuk, S K Loyalka, A B Lugão, K V Katti
We report here an innovative feature of green nanotechnology-focused work showing that mangiferin-a glucose functionalized xanthonoid, found in abundance in mango peels-serves dual roles of chemical reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords MGF-(198)AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while gamma rays are used for the quantitative estimation of gold within the tumors and various organs...
April 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28440202/oral-nano-delivery-systems-for-colon-targeting-therapy
#9
Tianxu Zhang, Guanyin Zhu, Boyao Lu, Qiang Peng
Targeting drug delivery is an attractive research area, as it enables localized treatment, improves the efficacy of therapeutics and reduces systemic toxicity. Colon targeting delivery is particularly beneficial to the treatment of colon diseases, such as inflammatory bowel disease and colon cancer, due to the improved local drug concentrations. The traditional strategies for colon targeting delivery include time-dependent and pH-dependent technologies, etc. In recent years, nanotechnology has emerged as a novel and efficient tool for targeting drug delivery...
April 24, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28439980/nanophotonic-trapping-precise-manipulation-and-measurement-of-biomolecular-arrays
#10
REVIEW
James E Baker, Ryan P Badman, Michelle D Wang
Optical trapping is a powerful and widely used laboratory technique in the biological and materials sciences that enables rapid manipulation and measurement at the nanometer scale. However, expanding the analytical throughput of this technique beyond the serial capabilities of established single-trap microscope-based optical tweezers remains a current goal in the field. In recent years, advances in nanotechnology have been leveraged to create innovative optical trapping methods that increase the number of available optical traps and permit parallel manipulation and measurement of arrays of optically trapped targets...
April 24, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28436961/the-evolving-landscape-of-drug-products-containing-nanomaterials-in-the-united-states
#11
Sheetal R D'Mello, Celia N Cruz, Mei-Ling Chen, Mamta Kapoor, Sau L Lee, Katherine M Tyner
The Center for Drug Evaluation and Research (CDER) within the US Food and Drug Administration (FDA) is tracking the use of nanotechnology in drug products by building and interrogating a technical profile of products containing nanomaterials submitted to CDER. In this Analysis, data from more than 350 products show an increase in the submissions of drug products containing nanomaterials over the last two decades. Of these, 65% are investigational new drugs, 17% are new drug applications and 18% are abbreviated new drug applications, with the largest class of products being liposomal formulations intended for cancer treatments...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28436959/peptide-mhc-based-nanomedicines-for-autoimmunity-function-as-t-cell-receptor-microclustering-devices
#12
Santiswarup Singha, Kun Shao, Yang Yang, Xavier Clemente-Casares, Patricia Solé, Antonio Clemente, Jesús Blanco, Qin Dai, Fayi Song, Shang Wan Liu, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Pascal Detampel, Matthias Amrein, César Fandos, Robert Tanguay, Susan Newbigging, Pau Serra, Anmar Khadra, Warren C W Chan, Pere Santamaria
We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease-relevant peptide-major histocompatibility complexes (pMHC) blunted autoimmune responses by triggering the differentiation and expansion of antigen-specific regulatory T cells in vivo. Here, we define the engineering principles impacting biological activity, detail a synthesis process yielding safe and stable compounds, and visualize how these nanomedicines interact with cognate T cells...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28436649/multi-arm-junctions-for-dynamic-dna-nanotechnology
#13
Shohei Kotani, William L Hughes
Non-enzymatic catalytic substrates have been engineered using toehold-mediated DNA strand displacement, and their programmable applications range from medical diagnosis to molecular computation. However, the complexity, stability, scalability, and sensitivity of those systems are plagued by network leakage. A novel way to suppress leakage is to increase its energy barrier through four-way branch migration. Presented here, we designed multi-arm junction substrates that simultaneously exploit four-way branch migration, with a high-energy barrier to minimize leakage, and three-way branch migration, with a low energy barrier to maximize catalysis...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28434891/nanotechnology-based-therapeutic-modality-to-boost-anti-tumor-immunity-and-collapse-tumor-defense
#14
REVIEW
Xiaomeng Hu, Tingting Wu, Yuling Bao, Zhiping Zhang
Cancer is still the leading cause of death. While traditional treatments such as surgery, chemotherapy and radiotherapy play dominating roles, recent breakthroughs in cancer immunotherapy indicate that the influence of immune system on cancer development is virtually beyond our expectation. Manipulating the immune system to fight against cancer has been thriving in recent years. Further understanding of tumor anatomy provides opportunities to put a brake on immunosuppression by overcoming tumor intrinsic resistance or modulating tumor microenvironment...
April 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28432320/formation-of-cuo-nano-flowered-surfaces-via-submerged-photo-synthesis-of-crystallites-and-their-antimicrobial-activity
#15
Fumika Nishino, Melbert Jeem, Lihua Zhang, Kazumasa Okamoto, Satoshi Okabe, Seiichi Watanabe
We report the fabrication of flower-like CuO nanostructured surfaces via submerged photo-synthesis of crystallites (SPSC), which requires only UV illumination in neutral water. In this paper, we discuss the reaction mechanism of the photochemical formation of the SPSC-fabricated CuO nanostructures in detail based on surface microstructural analyses and a radiation-chemical consideration with additional gamma-ray irradiation. Since the SPSC method for surface nanostructural fabrication can work at low temperatures at atmospheric pressure without using harmful substances, it is a potential fabrication method for green nanotechnology applications...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427532/nanotechnology-for-food-packaging-and-food-quality-assessment
#16
Marco Rossi, Daniele Passeri, Alberto Sinibaldi, Mariglen Angjellari, Emanuela Tamburri, Angela Sorbo, Elisabetta Carata, Luciana Dini
Nanotechnology has paved the way to innovative food packaging materials and analytical methods to provide the consumers with healthier food and to reduce the ecological footprint of the whole food chain. Combining antimicrobial and antifouling properties, thermal and mechanical protection, oxygen and moisture barrier, as well as to verify the actual quality of food, e.g., sensors to detect spoilage, bacterial growth, and to monitor incorrect storage conditions, or anticounterfeiting devices in food packages may extend the products shelf life and ensure higher quality of foods...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28427246/nanotechnology-and-diabetic-wound-healing-a-review
#17
Dinesh Kumar Chellappan, Yap Yenese, Chew Chian Wei, Gaurav Gupta
The incidence of diabetes has been on the rise and the rate of rise since the turn of this century has been phenomenal. One of the various battling issues faced by diabetics all over the globe is the management of diabetic wounds. Currently there are several management strategies to deal with the treatment of diabetic wounds. The conventional methods have several limitations. One of the major limitations is the rate and progression of healing of a diabetic wound when adopting a conventional diabetic wound management therapy...
April 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28426988/solar-photocatalytic-application-of-nbo2oh-as-alternative-photocatalyst-for-water-treatment
#18
Luana Márcia Bezerra Batista, Alexsandro Jhones Dos Santos, Djalma Ribeiro da Silva, Ana Paula de Melo Alves, Sergi Garcia-Segura, Carlos Alberto Martínez-Huitle
Water recycling and industrial effluents remediation are a hot topic of research to reduce the environmental impact of the human activity. Persistent organic pollutants are highly recalcitrant compounds with hazardous effects associated to their fate in water bodies. Several novel technologies have been developed during the last decades to deal with this novel contamination. However, the natural sources and idiosyncrasy of each country lead to the potential application of different technologies. In this context, we have focused on the development of phocotalytic treatment of solutions containing dyes using a novel photocatalytic material, the NbO2OH...
April 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28426070/controllable-synthesis-of-ferromagnetic-antiferromagnetic-core-shell-nws-with-tunable-magnetic-properties
#19
M Irfan, C J Wang, U Khan, W J Li, X M Zhang, W J Kong, P Liu, C H Wan, Y W Liu, X F Han
Several nanotechnology applications are based on the promising scheme of highly anisotropic magnetic nanomaterials. Using this idea, we investigated the structure, magnetic properties, and interfacial exchange anisotropy effects of the Ni/Cr2O3 and Fe/Cr2O3 core-shell nanowires (NWs) geometry. A template-based strategy was developed to synthesize Ni (Fe)-Cr2O3 core-shell NWs, which combines a wet-chemical route and electrodeposition within the nanopores of the membranes. Structural determination in correlation with magnetic testing shows that the crystalline Cr2O3-nanoshells (NSs) cause an enhanced exchange bias, providing an extra source of anisotropy that leads to their magnetic stability...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28424455/flow-virometry-analysis-of-envelope-glycoprotein-conformations-on-individual-hiv-virions
#20
Anush Arakelyan, Wendy Fitzgerald, Deborah F King, Paul Rogers, Hannah M Cheeseman, Jean-Charles Grivel, Robin J Shattock, Leonid Margolis
HIV-1 envelope proteins (Envs) play a critical role in HIV infection. In a correct trimeric conformation, Env mediates virus-cell binding and fusion. Malfunctioning of this machinery renders virions incapable of infecting cells. Each HIV-1 virion carries 10-14 Envs, and therefore a defective Env may not necessarily render a HIV virion non-infectious, since other Env on the same virion may still be functional. Alternatively, it is possible that on a given virion either all the spikes are defective or all are functional...
April 19, 2017: Scientific Reports
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