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bullous keratopathy

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https://www.readbyqxmd.com/read/29846421/descemet-s-membrane-endothelial-keratoplasty-with-a-simplified-technique-and-low-complication-rate-the-samba-technique
#1
Nicolas Cesário Pereira, Adriana Dos Santos Forseto, Myrna Serapião Dos Santos, Gustavo Grottone, Albert Santos, José Álvaro Pereira Gomes
PURPOSE: We report a simplified Descemet's membrane endothelial keratoplasty (DMEK) technique that involves safe and effective preparation and introduction, correct orientation, and easy unfolding of the donor graft inside the recipient anterior chamber. METHODS: In this retrospective study, we assessed the surgical outcomes of 26 eyes of 23 consecutive patients (mean age, 61.2 ± 11.4 yr; range, 39-82 yr) with Fuchs endothelial corneal dystrophy (n=19) or bullous keratopathy (n=7) who underwent the Samba technique, a simplified DMEK method, at the Sorocaba Ophthalmology Hospital, Sorocaba Eye Bank, Sorocaba, Brazil, between August 2011 and July 2012...
April 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29789014/a-review-of-scoring-systems-for-ocular-involvement-in-chronic-cutaneous-bullous-diseases
#2
REVIEW
Brendon W H Lee, Jeremy C K Tan, Melissa Radjenovic, Minas T Coroneo, Dedee F Murrell
BACKGROUND: Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity. The objectives of this report were, firstly, to document the prevalence and severity of ocular involvement in EB/AIBD...
May 22, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29787599/pathological-molecular-mechanism-of-symptomatic-late-onset-fuchs-endothelial-corneal-dystrophy-by-bioinformatic-analysis
#3
Zekai Cui, Qiaolang Zeng, Yonglong Guo, Shiwei Liu, Peiyuan Wang, Mengyuan Xie, Jiansu Chen
Fuchs endothelial corneal dystrophy (FECD) is a degenerative disease characterized by corneal endothelial decompensation. FECD causes corneal stromal and epithelial edema and progressively develops into bullous keratopathy, which can eventually lead to blindness. However, the exact pathogenesis is unknown. In this study, we performed an in-depth bioinformatic analysis of the dataset GSE74123 to determine the differentially expressed genes (DEGs) of symptomatic late-onset FECD compared with a normal control...
2018: PloS One
https://www.readbyqxmd.com/read/29766356/endothelial-cell-loss-and-graft-survival-after-penetrating-keratoplasty-for-laser-iridotomy-induced-bullous-keratopathy
#4
Naoki Okumura, Ayaka Kusakabe, Noriko Koizumi, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita
PURPOSE: To assess corneal endothelial cell loss after penetrating keratoplasty (PK) treatment for laser iridotomy (LI)-induced bullous keratopathy (BK). METHODS: A retrospective study conducted on consecutive patients who underwent PK between March 2000 and December 2011. Patients who had undergone more than 24 months of follow-up were included. Patients who underwent PK were subcategorized into two groups based on their diagnosis of BK prior to PK; PK was performed to treat either LI-BK or non LI-BK...
May 15, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29765780/outcomes-and-complications-of-scleral-fixated-intraocular-lens-combined-with-ahmed-tube-surgery
#5
Nikhel Sachdev, Maria Cecilia Aquino, Seng Chee Loon, Yiong Huak Chan, Paul Chew, Victor Koh
Background: To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design: This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at Singapore's National University Hospital. Participants underwent an Ahmed tube surgery, together with transscleral suture-fixated posterior chamber intraocular lens...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29755822/descemet-membrane-endothelial-keratoplasty-with-irregular-edged-graft-a-salvage-method-for-large-radial-graft-tears
#6
Mehmet Cüneyt Özmen, Nilay Dilekmen, Erdem Yüksel, Bahri Aydın, Fikret Akata
Large radial tears of donor Descemet membrane (DM) during the preparation of Descemet membrane endothelial keratoplasty (DMEK) grafts can make the trephination stage impossible because of small graft diameter. This results in irregular-edged grafts. In this study, we report two pseudophakic bullous keratopathy patients who underwent DMEK surgery with irregular-edged Descemet membrane (DM) grafts. Main outcome measures were preoperative and postoperative 1-, 3-, and 6-month best corrected visual acuity (BCVA), endothelial cell density (ECD) and central corneal thickness (CCT)...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29697353/graft-failure-and-repeat-penetrating-keratoplasty
#7
Ozlem Barut Selver, Irmak Karaca, Melis Palamar, Sait Egrilmez, Ayse Yagci
OBJECTIVES: In this study, we report the indications and outcomes of repeat penetrating keratoplasty and the reasons for graft failure. MATERIALS AND METHODS: We performed a retrospective data analysis of patients who had undergone 2 or more penetrating keratoplasties for the same eye between 1991 and 2016. RESULTS: Among 1613 penetrating keratoplasties, 149 regrafts of 105 eyes were reviewed. The mean follow-up time after repeat penetrating keratoplasty was 3...
April 26, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29692490/glued-intraocular-lens-with-descemet-stripping-endothelial-keratoplasty-in-aphakic-bullous-keratopathy
#8
Anita Mani, P S Moulick, Alok Sati, Sandeep Gupta
No abstract text is available yet for this article.
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29681843/wheel-spokes-technique-for-endothelial-keratoplasty-for-extremely-mydriatic-bullous-keratopathy-eyes-without-capsular-support
#9
Hidenori Tanaka, Koji Hirano, Masayuki Horiguchi
We describe a new technique to prevent an endothelial donor graft from dropping into the vitreous cavity during non-Descemet stripping automated endothelial keratoplasty (nDSAEK) for extremely mydriatic bullous keratopathy (BK) eyes without capsular support. The patient was a 79-year-old woman who underwent nDSAEK for an extremely mydriatic BK eye with an incomplete barrier between the anterior and posterior chambers. She had undergone argon laser iridotomy for acute glaucoma at the age of 59 years and cataract surgery 3 years later...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681179/-femtosecond-laser-assisted-keratoplasty
#10
László Módis, Eszter Szalai, Zsuzsanna Flaskó, Bence Kolozsvári, András Berta
INTRODUCTION AND AIM: To present our results on femtosecond laser-assisted penetrating keratoplasty. PATIENTS AND METHOD: Twenty-five eyes of 25 patients underwent surgery with the following indications: pseudophakic bullous keratopathy (n = 10), keratoconus (n = 4), corneal dystrophy (n = 5), corneal scar (n = 4), band keratopathy (n = 2). Trephination of both the donor and recipient corneas were performed with VisuMax femtosecond laser device (Carl Zeiss Meditec AG, Jena, Germany)...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29675350/postoperative-intraocular-lens-opacification
#11
Shang-Te Ma, Chung-May Yang, Yu-Chih Hou
Intraocular lens (IOL) opacification is rare but may occur after non-Descemet stripping automated endothelial keratoplasty (n-DSAEK) or intravitreal air injection after pars plana vitrectomy (PPV). We reported two cases of IOL opacification within the pupillary region. Chart was retrospectively reviewed. The predisposing factors and the visual acuity were analyzed. The opacification was evaluated by anterior segment optical coherence tomography (AS-OCT). A 68-year-old healthy woman with pseudophakic bullous keratopathy underwent uneventful n-DSAEK in the right eye...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29619650/endothelial-keratoplasty-in-eyes-with-a-retained-angle-supported-intraocular-lens
#12
Konstantinos Droutsas, Apostolos Lazaridis, George Kymionis, Klio Chatzistefanou, Dimitris Papaconstantinou, Walter Sekundo, Chryssanthi Koutsandrea
PURPOSE: To describe the outcomes of endothelial keratoplasty (EK) for bullous keratopathy in eyes with a retained angle-supported anterior chamber intraocular lens (acIOL). METHODS: Among 263 consecutive EK procedures, 7 DMEK and 11 DSAEK procedures were identified in eyes with an acIOL and included in the present retrospective case series. Pre- and postoperative status including ocular history, anatomical outcome and complications as well as best-corrected visual acuity was evaluated...
April 4, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29573998/painless-bilateral-bullous-keratopathy
#13
Stephen J Vincent
Bullous keratopathy is a pathological corneal condition that arises due to irreversible oedema associated with endothelial cell loss or dysfunction. Symptoms may vary from mild (transient blurred vision and increased glare from epithelial oedema) to severe (an acute and significant loss of vision associated with frank endothelial decompensation, and pain due to ruptured epithelial bullae). Possible treatments to restore vision and minimise pain include topical hypertonic agents, bandage contact lenses, superficial anterior corneal surgical procedures or penetrating full thickness or endothelial keratoplasty...
March 21, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29567793/corneal-transplant-follow-up-study-ii-ctfs-ii-a-prospective-clinical-trial-to-determine-the-influence-of-hla-class-ii-matching-on-corneal-transplant-rejection-baseline-donor-and-recipient-characteristics
#14
W John Armitage, Helen L Winton, Mark N A Jones, Julie M Crewe, Chris A Rogers, Derek M Tole, Andrew D Dick
PURPOSE: To describe a study to determine the influence of HLA class II matching on allograft rejection of high-risk, full-thickness corneal transplants. METHODS: A prospective, longitudinal, clinical trial (ISRCTN25094892) with a primary outcome measure of time to first clinically determined rejection episode. Tissue typing used DNA-based techniques. Corneas were allocated to patients with ≤2 human leucocyte antigen (HLA) class I antigen mismatches by cohort minimisation to achieve 0, 1 or 2 HLA class II (HLA-DR) antigen mismatches...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29561350/sulfur-hexafluoride-20-versus-air-100-for-anterior-chamber-tamponade-in-dmek-a-meta-analysis
#15
Raquel Esteves Marques, Paulo Silva Guerra, David Cordeiro Sousa, Nuno Pinto Ferreira, Ana Inês Gonçalves, Ana Miguel Quintas, Walter Rodrigues
PURPOSE: To compare intracameral 20% sulfur hexafluoride (SF6) versus 100% air as tamponade for graft attachment in Descemet membrane endothelial keratoplasty (DMEK). METHODS: Using an electronic database search on MEDLINE and CENTRAL from inception to December 2017, we performed a literature review and meta-analysis including all comparative studies of SF6 at a 20% concentration (20% SF6) versus pure air (100% air) for anterior chamber tamponade in DMEK. The primary outcome was the rebubbling rate at the final observation...
June 2018: Cornea
https://www.readbyqxmd.com/read/29539291/injection-of-cultured-cells-with-a-rock-inhibitor-for-bullous-keratopathy
#16
Shigeru Kinoshita, Noriko Koizumi, Morio Ueno, Naoki Okumura, Kojiro Imai, Hiroshi Tanaka, Yuji Yamamoto, Takahiro Nakamura, Tsutomu Inatomi, John Bush, Munetoyo Toda, Michio Hagiya, Isao Yokota, Satoshi Teramukai, Chie Sotozono, Junji Hamuro
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density. METHODS: We performed an uncontrolled, single-group study involving 11 persons who had received a diagnosis of bullous keratopathy and had no detectable CECs...
March 15, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29534662/primary-bullous-keratopathy-in-a-patient-with-werner-syndrome-treated-with-corneal-transplant
#17
Divya Singh, Anita Ganger, Noopur Gupta, Murugesan Vanathi, Rajesh Khadgawat, Radhika Tandon
Here, we present, to the best of our knowledge, the first case of Werner syndrome with corneal blindness due to bilateral primary bullous keratopathy. Werner syndrome is a rare autosomal recessive disorder characterized by features of premature aging, insulin-dependent diabetes mellitus, osteoporosis, atherosclerosis, hypergonadotrophic hypogonadism, hypertriglyceridemia, scleroderma-like skin changes, and sarcomas. Among ocular manifestations, cataracts, cystoid macular edema, and retinal detachment have been reported...
March 9, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29531856/human-corneal-endothelial-cell-transplantation-using-nanocomposite-gel-sheet-in-bullous-keratopathy
#18
Periasamy Parikumar, Kazutoshi Haraguchi, Rajappa Senthilkumar, Samuel Jk Abraham
Transplantation of in vitro expanded human corneal endothelial precursors (HCEP) cells using a nanocomposite (D25-NC) gel sheet as supporting material in bovine's cornea has been earlier reported. Herein we report the transplantation of HCEP cells derived from a cadaver donor cornea to three patients using the NC gel sheet. In three patients with bullous keratopathy, one after cataract surgery, one after trauma and another in the corneal graft, earlier performed for congenital corneal dystrophy, not amenable to medical management HCEP cells isolated from a human cadaver donor cornea in vitro expanded using a thermoreversible gelation polymer (TGP) for 26 days were divided into three equal portions and 1...
2018: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29528002/descemet-membrane-endothelial-keratoplasty-outcomes-in-the-first-year-of-experience
#19
Dilek D Altınörs, Leyla Asena
OBJECTIVES: We aimed to report the clinical outcomes of Descemet membrane endothelial keratoplasty in our first year of experience. MATERIALS AND METHODS: Patients who underwent Descemet membrane endothelial keratoplasty at the Baskent University Faculty of Medicine, Department of Ophthalmology, between 2015 and 2016 were included in the study. Patient demographics, cause of endothelial dysfunction, best-corrected visual acuity, central corneal thickness, graft survival, follow-up duration, and intraoperative and postoperative complications were recorded...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29483081/progressive-idiopathic-unilateral-corneal-endothelial-failure-of-unknown-aetiology-in-phakic-eyes
#20
Weng Hon Lee, Adrian Tey, Kevin Gales, Hardeep Singh Mudhar, Francisco C Figueiredo
AIM: To describe a cohort of patients with irreversible unilateral bullous keratopathy (BK) of undetermined aetiology. METHOD: Retrospective, single-centre case series in a tertiary corneal referral centre. RESULTS: Eleven consecutive patients (nine females; mean age 71.7 years) presented from 1999 to 2009 with acute onset unilateral visual loss. At presentation, the best-corrected visual acuity of the affected eyes was 6/9 or worse with mean central corneal thickness (CCT) of 684 (SD 66) μm...
February 26, 2018: British Journal of Ophthalmology
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