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bullous keratopathy

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https://www.readbyqxmd.com/read/29211700/effect-of-histocompatibility-y-antigen-matching-on-graft-survival-in-primary-penetrating-keratoplasty
#1
Mi Jin Kim, Joo Hyun Kim, Hyun Sun Jeon, Won Ryang Wee, Joon Young Hyon
PURPOSE: To investigate the influence of histocompatibility Y (H-Y) antigen matching on corneal graft survival in primary penetrating keratoplasty (PK). METHODS: Medical records of patients who underwent primary PK at Seoul National University Bundang Hospital between June 2005 and October 2015 were retrospectively analyzed. The eyes were classified into 2 groups: H-Y-compatible (115 eyes) and H-Y-incompatible (23 eyes). The H-Y-compatible group included donor/recipient combinations of male/male (57 eyes), female/male (44 eyes), and female/female (14 eyes)...
January 2018: Cornea
https://www.readbyqxmd.com/read/29137083/indications-and-outcomes-of-pediatric-keratoplasty-in-a-tertiary-eye-care-center-a-retrospective-review
#2
Rosario Gulias-Cañizo, Roberto Gonzalez-Salinas, Luis Fernando Hernandez-Zimbron, Everardo Hernandez-Quintela, Valeria Sanchez-Huerta
To evaluate indications and outcomes of pediatric keratoplasty in a tertiary eye center, and identify factors that affect visual outcomes.We performed a retrospective review of penetrating keratoplasty in children aged 0 to 18 years between 1995 and 2011 in the Asociación para Evitar la Ceguera en México IAP, Hospital "Dr. Luis Sánchez Bulnes".A total of 574 penetrating keratoplasties were performed during the study interval. Median follow-up was 5.0 years. Main indications included keratoconus (55.58%), postherpetic scarring (9...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132691/-practical-assessment-of-dsaek-in-the-management-of-endothelial-decompensation-following-penetrating-keratoplasty
#3
E Neiter, C Goetz, F Tortuyaux, A Ehrhardt, N Houmad, J-M Perone
PURPOSE: To report our anatomical and functional results as well as possible complications of the first six Descemet's stripping endothelial keratoplasties (DSAEK) performed in our department for endothelial decompensation after penetrating keratoplasty (PK) METHODS: This was a retrospective and observational monocentric study of six patients with DSAEK after prior PK between January 2015 and July 2016. The data collected were: demographic characteristics (age, sex), ophthalmological comorbidities, initial indication for PK, delay between PK and DSAEK...
November 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29118495/emergency-visits-after-corneal-transplantation-in-yemen
#4
Mahfouth Abdalla Bamashmus, Saleh A Al-Akily, Hisham A AlAkhalee, Khaldoon O Al-Nuseriy, Marwan H Farhan
PURPOSE: Awareness of symptoms and signs of possible complications after corneal transplantation is very important. Early presentation can enhance long-term survival of the cornea. This study evaluates the reasons for emergency presentation and management of postcorneal transplantation complications. PATIENTS AND METHODS: This retrospective study included a total of 134 postkeratoplasty patients at the cornea unit in Yemen Magrabi Eye Hospital in Sana'a between 2008 and 2010...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29089772/isolated-descemetorhexis-for-anterior-synechiolysis-prior-to-endothelial-keratoplasty-case-report-and-technique
#5
Konstantinos Droutsas, Konstantinos Andreanos, Apostolos Lazaridis, Ilias Georgalas, George Kymionis, Dimitris Papaconstantinou
PURPOSE: To describe the utilization of descemetorhexis for reformation of the anterior chamber in eyes with central iridocorneal synechiae before endothelial keratoplasty (EK). METHODS: A 71-year-old man with a history of trabeculectomy complicated by hypotony presented with bullous keratopathy in the presence of extensive iridocorneal synechiae and a flat anterior chamber. In order to proceed with EK, synechiolysis with the use of viscoelastic and scissors was attempted...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29074873/regulatory-compliant-tissue-engineered-human-corneal-endothelial-grafts-restore-corneal-function-of-rabbits-with-bullous-keratopathy
#6
Gary S L Peh, Heng-Pei Ang, Chan N Lwin, Khadijah Adnan, Benjamin L George, Xin-Yi Seah, Shu-Jun Lin, Maninder Bhogal, Yu-Chi Liu, Donald T Tan, Jodhbir S Mehta
Corneal transplantation is the only treatment available to restore vision for individuals with blindness due to corneal endothelial dysfunction. However, severe shortage of available donor corneas remains a global challenge. Functional regulatory compliant tissue-engineered corneal endothelial graft substitute can alleviate this reliance on cadaveric corneal graft material. Here, isolated primary human corneal endothelial cells (CEnCs) propagated using a dual media approach refined towards regulatory compliance showed expression of markers indicative of the human corneal endothelium, and can be tissue-engineered onto thin corneal stromal carriers...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051590/association-between-corneal-endothelial-cell-densities-and-elevated-cytokine-levels-in-the-aqueous-humor
#7
Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Kazunari Higa, Terumasa Suzuki, Naohiko Aketa, Murat Dogru, Yoshiyuki Satake, Jun Shimazaki
Annual reduction rate of corneal endothelial cell density (ECD) varies among etiologies, however, the cause of chronic endothelial cell loss is still unknown. We recently reported the elevation of inflammatory cytokines in the aqueous humor (AqH) in eyes with bullous keratopathy and low ECD. To evaluate the association between ECD and aqueous cytokine levels, we collected a total of 157 AqH samples prospectively. The AqH levels of cytokines were measured and multivariate analyses were conducted to find the correlation between ECD, aqueous cytokine levels and clinical factors, such as number of previous intraocular surgeries and protein concentration in AqH...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29034156/intraocular-lens-opacification-after-descemet-s-stripping-automated-endothelial-keratoplasty
#8
Meng-Sheng Lee, I-Lun Tsai, Ching-Yao Tsai, Li-Lin Kuo, Shiow-Wen Liou, Lin-Chung Woung
Compared with conventional penetrating keratoplasty, Descemet's stripping automated endothelial keratoplasty (DSAEK) more effectively maintain global integrity and rapid vision rehabilitation with less ocular surface disorders in patients with endothelial dysfunction. Here, we report a case of a 76-year-old woman who experienced opacification of a hydrophilic intraocular lens (IOL) approximately 10 months after DSAEK. The patient with no history of systemic disease developed pseudophakic bullous keratopathy in the right eye 2 years after undergoing cataract surgery...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29016407/a-novel-entity-of-corneal-diseases-with-irregular-posterior-corneal-surfaces-concept-and-clinical-relevance
#9
Takefumi Yamaguchi, Eisuke Shimizu, Yukari Yagi-Yaguchi, Daisuke Tomida, Yoshiyuki Satake, Jun Shimazaki
Various corneal diseases, such as hereditary corneal dystrophies, corneal infection, and bullous keratopathy, cause corneal opacity, scarring, and edema, leading to severely decreased visual acuity and loss of vision. These diseases were regarded as corneal opacity diseases, and the decreased visual acuity was considered to be predominantly caused by corneal opacity. The influence of corneal irregular astigmatism on vision has been poorly understood to date, mainly because accurate quantification of irregular astigmatism has been technically challenging...
November 2017: Cornea
https://www.readbyqxmd.com/read/28985815/young-donor-graft-assisted-endothelial-keratoplasty-pdek-dmek-with-epithelial-debridement-for-chronic-pseudophakic-bullous-keratopathy
#10
Amar Agarwal, Priya Narang, Dhivya A Kumar, Ashvin Agarwal
OBJECTIVE: The aim of this study was to describe the applicability and report visual outcomes for the treatment of subepithelial fibrosis and anterior stromal scarring in cases of chronic pseudophakic bullous keratopathy (PBK) with epithelial debridement and endothelial keratoplasty (EK) (pre-Descemet endothelial keratoplasty [PDEK]; Descemet membrane endothelial keratoplasty [(DMEK]) using young donor tissue. DESIGN: Prospective, single-centre, interventional study...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28968295/descemet-membrane-endothelial-transfer-ultimate-outcome
#11
Rénuka S Birbal, Jack Parker, Martin Dirisamer, Ana Janićijević, Lamis Baydoun, Isabel Dapena, Gerrit R J Melles
PURPOSE: To evaluate the clinical outcome of 16 eyes undergoing Descemet membrane endothelial transfer (DMET). METHODS: In this retrospective cohort study, a consecutive series of 16 eyes from 16 patients was evaluated after subtotal detachment of the Descemet graft after a Descemet membrane endothelial keratoplasty procedure (n = 8) or intended DMET (n = 8) for either Fuchs endothelial dystrophy (n = 10) or bullous keratopathy (BK; n = 6). RESULTS: All 8 Descemet membrane endothelial keratoplasty procedures were complicated by subtotal detachment of the donor graft...
September 29, 2017: Cornea
https://www.readbyqxmd.com/read/28957977/single-pass-4-throw-pupilloplasty-for-pre-descemet-endothelial-keratoplasty
#12
Priya Narang, Amar Agarwal, Dhivya A Kumar
PURPOSE: To describe the feasibility and applicability of the single-pass 4-throw pupilloplasty (SFT) technique in the Pre-Descemet endothelial keratoplasty (PDEK) procedure. METHODS: In cases with endothelial decompensation and pupil deformity, SFT was performed to prevent the escape of air into the posterior segment. Fourier domain anterior segment optical coherence tomography was performed to analyze elevation of the iris and the suture tail end from the iris plane...
December 2017: Cornea
https://www.readbyqxmd.com/read/28937416/a-novel-entity-of-corneal-diseases-with-irregular-posterior-corneal-surface-concept-and-clinical-relevance
#13
Takefumi Yamaguchi, Eisuke Shimizu, Yukari Yagi-Yaguchi, Daisuke Tomida, Yoshiyuki Satake, Jun Shimazaki
Various corneal diseases, such as hereditary corneal dystrophies, corneal infection, and bullous keratopathy, cause corneal opacity, scarring, and edema, leading to severely decreased visual acuity and loss of vision. These diseases were regarded as corneal opacity diseases, and the decreased visual acuity was considered to be predominantly caused by corneal opacity. The influence of corneal irregular astigmatism on vision has been poorly understood to date, mainly because accurate quantification of irregular astigmatism has been technically challenging...
September 19, 2017: Cornea
https://www.readbyqxmd.com/read/28825920/rabbit-model-of-corneal-endothelial-injury-established-using-the-nd-yag-laser
#14
Weijie Zhang, Yang Hu, Linna Lu, Yan Liu, Xiaodan Yang, Hao Sun, Jing Ruan, Junzhao Chen, Qinke Yao, Chenxi Yan, Ping Gu, Yao Fu, Chunyi Shao, Xianqun Fan
PURPOSE: To develop a new rabbit model of corneal endothelial injury using a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. METHODS: The corneal endothelia of 2 groups of New Zealand white rabbits were treated with an Nd:YAG laser in a uniformly scattered fashion. Rabbits in group A underwent laser burns on the whole corneal endothelium, including the limbus area, whereas rabbits in group B were subjected to laser burns in the central 9-mm diameter zone of the endothelium...
October 2017: Cornea
https://www.readbyqxmd.com/read/28742620/comparison-of-5-sulfur-hexafluoride-versus-100-air-tamponade-in-descemet-membrane-endothelial-keratoplasty
#15
Paraskevas Ampazas, Konstantinos Droutsas, Eleftherios Giallouros, Frank M Schroeder, Walter Sekundo
PURPOSE: To compare the rebubbling rate and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) with 5% sulfur hexafluoride (SF6) gas versus 100% air as a tamponade for graft attachment. METHODS: Retrospective, comparative, interventional case series including 368 consecutive pseudophakic eyes with Fuchs endothelial dystrophy or pseudophakic bullous keratopathy that underwent DMEK in a tertiary referral center between October 2010 and August 2015 using either air (group 1, 191 eyes) or 5% SF6 (group 2, 177 eyes) as a tamponade...
October 2017: Cornea
https://www.readbyqxmd.com/read/28742617/simple-single-pass-technique-for-ultrathin-descemet-stripping-automated-endothelial-keratoplasty-a-pilot-study
#16
Maria E S Dimitry, Adam D Lewis, Fani Zacharaki, Manju Chandran, Deana Robson, Geeta Menon, Thomas R G Poole
PURPOSE: To assess intraoperative and postoperative graft thickness (GT) after donor deturgescence for ultrathin Descemet stripping automated endothelial keratoplasty and to evaluate visual outcomes, endothelial cell density, and patient satisfaction at 1 year. METHODS: Prospective interventional case series of patients with Fuchs endothelial dystrophy, Fuchs endothelial dystrophy and cataract, and pseudophakic bullous keratopathy (n = 12 grafts). The donor cornea was allowed to thin out by simple evaporation on an artificial anterior chamber, to the required precut thickness, before a single microkeratome pass...
October 2017: Cornea
https://www.readbyqxmd.com/read/28739420/long-term-visual-outcomes-comparing-descemet-stripping-automated-endothelial-keratoplasty-and-penetrating-keratoplasty
#17
COMPARATIVE STUDY
Matthias Fuest, Marcus Ang, Hla Myint Htoon, Donald Tan, Jodhbir S Mehta
PURPOSE: To compare 5-year visual acuity and refraction outcome in Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) for Fuchs endothelial dystrophy (FED) or bullous keratopathy (BK) in Asian eyes. DESIGN: Prospective interventional case series. METHODS: We analyzed 828 consecutive cases of DSAEK (423) or PK (405) for FED and BK from the Singapore Cornea Transplant Registry performed from 1991 to 2011...
October 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28688026/indications-and-graft-survival-analysis-in-optical-penetrating-keratoplasty-in-a-tertiary-care-center-in-north-india-a-5-year-study
#18
Sudesh Kumar Arya, Amit Raj, Ravi Kant Bamotra, Anubha Bhatti, Jyoti Deswal, Meenakshi Sindhu
PURPOSE: To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India. PARTICIPANTS: All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetrating keratoplasty done for therapeutic purposes were included in the study. Patients with follow-up less than 2 years were excluded from the study. MATERIALS AND METHODS: Data were obtained by reviewing the records of 101 patients who underwent optical penetrating keratoplasty from 2008 to 2013 for various indications...
July 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28652692/combined-30-degree-bevel-up-and-down-technique-against-0-degree-phaco-tip-for-phacoemulsification-surgery-of-hard-cataracts
#19
Rajesh Subhash Joshi, Sonal Jayant Muley
PURPOSE: To evaluate the effective phaco time (EPT), cumulative dissipated energy (CDE) and nucleus emulsification time (NET) as phaco parameters with 0- and 30-degree phaco tip. PATIENTS AND METHODS: This prospective, interventional and observational case series included 294 patients scheduled for cataract removal by phacoemulsification technique. Patients with nuclear cataracts of grade 4 and 5 nuclear opalescence of Lens Opacities Classification System III were included in the study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28648760/corneal-endothelial-cells-activate-innate-and-acquired-arm-of-anti-viral-responses-after-cytomegalovirus-infection
#20
Dai Miyazaki, Ryu Uotani, Michiko Inoue, Tomoko Haruki, Yumiko Shimizu, Keiko Yakura, Satoru Yamagami, Tatsuo Suzutani, Mayumi Hosogai, Hiroki Isomura, Yoshitsugu Inoue
Infection of the corneal endothelial cells by human cytomegalovirus (CMV) is an important cause of corneal endotheliitis. CMV endotheliitis is difficult to completely cure and relapses are frequent. This can cause blinding corneal bullous keratopathy. However, the pathogenesis of CMV endotheliitis remains undetermined. To understand the immunopathology of endotheliitis, we examined how corneal endothelial cells prime the anti-viral immunity after CMV infection based on global transcriptional responses. To accomplish this, human corneal endothelial (HCEn) cells were infected with CMV, and the global transcriptional responses were determined by microarray analyses for primary anti-viral responses using network analysis...
August 2017: Experimental Eye Research
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