keyword
MENU ▼
Read by QxMD icon Read
search

intrastromal

keyword
https://www.readbyqxmd.com/read/27899371/refractive-improvements-and-safety-with-topography-guided-corneal-crosslinking-for-keratoconus-1-year-results
#1
Maria Nordström, Maria Schiller, Anneli Fredriksson, Anders Behndig
PURPOSE: To assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen for corneal crosslinking in progressive keratoconus. METHODS: An open-label prospective randomised clinical trial was performed at the Department of Clinical Sciences, Ophthalmology, Umeå University Hospital, Umeå, Sweden. Thirty-seven patients (50 eyes) with progressive keratoconus planned for corneal crosslinking were included. The patients were randomised to topography-guided crosslinking (photorefractive intrastromal crosslinking (PiXL); n=25) or uniform 9 mm crosslinking (corneal collagen crosslinking (CXL); n=25)...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27844206/ex-vivo-rabbit-and-human-corneas-as-models-for-bacterial-and-fungal-keratitis
#2
Abigail Pinnock, Nagaveni Shivshetty, Sanhita Roy, Stephen Rimmer, Ian Douglas, Sheila MacNeil, Prashant Garg
PURPOSE: In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models. METHODS: Excised rabbit and human corneoscleral rims maintained in organ culture were infected using 10(8) cells of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans or Fusarium solani...
November 14, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27826683/aspergillus-flavus-keratitis-experience-of-a-tertiary-eye-clinic-in-turkey
#3
Elif Erdem, Meltem Yagmur, Hazal Boral, Macit Ilkit, Reha Ersoz, Seyedmojtaba Seyedmousavi
We investigated the clinical and mycological characteristics of four cases of mycotic keratitis caused by Aspergillus flavus that occurred from July 2014 to May 2015 at Çukurova University Hospital, Adana, Turkey. In a 10-month period, a total of 64 corneal smear/scrapings were examined from patients with suspected mycotic keratitis. Fungal cultures were positive in six of these patients, indicating a 9.4% incidence of mycotic keratitis in this region, including four cases of A. flavus and two cases of Fusarium spp...
November 8, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27824384/refractive-lenticule-transplantation-for-correction-of-iatrogenic-hyperopia-and-high-astigmatism-after-lasik
#4
Apostolos Lazaridis, Dan Z Reinstein, Timothy J Archer, Stephan Schulze, Walter Sekundo
PURPOSE: To design a technique for intrastromal transplantation of stromal lenticules with specific refractive power for correction of post-LASIK induced hyperopia and astigmatism. METHODS: A 28-year-old patient was referred for consultation after complicated LASIK for moderate myopia and astigmatism. The refractive error of the right eye was severely overcorrected due to data entry error. Post-LASIK refraction showed high astigmatism (right eye: +6.50 -9.00 @ 84°) and corrected distance visual acuity (CDVA) of 20/32...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27795856/polar-value-analysis-of-corneal-astigmatism-in-intrastromal-corneal-ring-segment-implantation
#5
Chang Rae Rho, Min-Ji Kim, Choun-Ki Joo
Purpose. To evaluate surgically induced astigmatism (SIA) and the average corneal power change in symmetric intrastromal corneal ring segment (ICRS) implantation. Methods. The study included 34 eyes of 34 keratoconus patients who underwent symmetric Intacs SK ICRS implantation. The corneal pocket incision meridian was the preoperative steep meridian. Corneal power data were obtained before and 3 months after Intacs SK ICRS implantation using scanning-slit topography. Polar value analysis was used to evaluate the SIA...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27721986/a-combination-of-intrastromal-and-intracameral-injections-of-amphotericin-b-in-the-treatment-of-severe-fungal-keratitis
#6
Jianzhang Hu, Jingjin Zhang, Yanling Li, Xiaoli Han, Weidong Zheng, Juan Yang, Guoxing Xu
Purpose. To evaluate the efficacy of a combination of intrastromal and intracameral injections of amphotericin B in the treatment of severe recalcitrant fungal keratitis. Methods. Patients with severe fungal keratitis who were resistant to conventional antifungal medical treatments and needed potential surgical intervention were recruited at the First Affiliated Hospital of Fujian Medical University between January 2012 and July 2013. The patients were treated with a combination of intrastromal and intracameral injections of amphotericin B (25 μg/mL and 50 μg/mL, resp...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27709355/rapidly-dissolving-polymeric-microneedles-for-minimally-invasive-intraocular-drug-delivery
#7
Raghu Raj Singh Thakur, Ismaiel A Tekko, Farhan Al-Shammari, Ahlam A Ali, Helen McCarthy, Ryan F Donnelly
In this study, dissolving microneedles (MNs) were used to enhance ocular drug delivery of macromolecules. MNs were fabricated using polyvinylpyrrolidone (PVP) polymer of various molecular weights (MWs) containing three model molecules of increasing MW, namely fluorescein sodium and fluorescein isothiocyanate-dextrans (with MW of 70 k and 150 k Da). Arrays (3 × 3) of PVP MNs with conical shape measuring about 800 μm in height with a 300 μm base diameter, containing the model drugs, were fabricated and characterized for their fracture forces, insertion forces (in the sclera and cornea), depth of penetration (using OCT and confocal imaging), dissolution time and in vitro permeation...
December 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27698700/matrix-metalloproteinase-14-participates-in-corneal-lymphangiogenesis-through-the-vegf-c-vegfr-3-signaling-pathway
#8
Hai-Tao Du, Ping Liu
The aim of the present study was to investigate the roles of matrix metalloproteinase 14 (MMP-14) in corneal inflammatory lymphangiogenesis. The expression of MMP-14 in vivo was detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays, under various corneal conditions. pCMV-MMP-14 or empty pCMV vectors were injected into mouse corneal stroma, 3 days after suture placement in a standard suture-induced inflammatory corneal neovascularization assay...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27672592/evaluation-of-anterior-and-posterior-surfaces-of-the-cornea-using-a-dual-scheimpflug-analyzer-in-keratoconus-patients-implanted-with-intrastromal-corneal-ring-segments
#9
Leonardo Torquetti, Carlos Arce, Jesús Merayo-Lloves, Guilherme Ferrara, Paulo Ferrara, Brenno Signorelli, Armando Signorelli
AIM: To evaluate corneal parameters measured with a dual Scheimpflug analyzer in keratoconus patients implanted with intrastromal corneal ring segments (ICRS). METHODS: Fifty eyes of 40 keratoconus patients had Ferrara ICRS implantation from November 2010 to April 2014. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refraction, keratometry, asphericity, elevation, pachymetry, root mean square (RMS), spherical aberration and coma were studied...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27661992/measuring-intraocular-pressure-in-patients-with-keratoconus-with-and-without-intrastromal-corneal-ring-segments
#10
Carmen Mendez-Hernandez, Paula Arribas-Pardo, Ricardo Cuiña-Sardiña, Cristina Fernandez-Perez, Rosalia Mendez-Fernandez, Federico Saenz-Frances, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
PURPOSE: To compare intraocular pressure (IOP) measurements made using 5 tonometers in keratoconic eyes with and without intrastromal corneal ring segments. METHODS AND PATIENTS: This was an observational case series study. A total of 147 eyes of 147 patients with keratoconus, 74 of which had undergone corneal ring segment placement, were prospectively evaluated. IOP was measured using the tonometers Tonopen XL, Pascal dynamic contour tonometer, iCare Pro, ocular response analyzer (ORA), and Goldmann applanation (GAT) in random order...
September 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27661066/femtosecond-assisted-big-bubble-a-feasibility-study
#11
Vasilios F Diakonis, Sonia H Yoo, Victor Hernandez, Vardhaman P Kankariya, Florence Cabot, Maria P Fernandez-Jimenez, Sander R Dubovy, Jean-Marie Parel
PURPOSE: To evaluate the feasibility of femtosecond laser-assisted (FA) tunnel creation as a pretreatment for creating a big bubble (BB) to pneumo-dissect the corneal stroma from Descemet membrane. METHODS: Five human cadaver eyes received pretreatment using a femtosecond laser. An intrastromal tunnel, along with a side cut, was achieved using customized femtosecond corneal disruption (custom mask). Before treatment, optical coherence tomography was performed and the intrastromal tunnel was intended to achieve a parallel orientation with respect to the corneal endothelial cell layer (50 µm above the endothelium)...
September 21, 2016: Cornea
https://www.readbyqxmd.com/read/27658971/-first-experience-with-femtosecond-laser-presbyopia-correction-method-intracor
#12
P Žiak, K Lucká, P Mojžiš, I Katuščáková, J Halička
: We report the first experience with presbyopia correcting femtosecond laser surgical procedure INTRACOR. This procedure is so far the only one that is made purely intrastromally without generating a wound connected to corneal surface or anterior chamber.Presbyopia - caused by physiological aging and decreasing elasticity of the lens, impairs patients accommodative ability. In the case of the method INTRACOR, presbyopia is corrected by steepening of corneal curvature in the central optical zone...
2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27652132/the-role-of-anterior-segment-optical-coherence-tomography-in-the-management-of-an-intra-corneal-foreign-body
#13
Ali Riza Cenk Celebi, Ayse Ebru Kilavuzoglu, Ugur Emrah Altiparmak, C Banu Cosar, Abdullah Ozkiris
INTRODUCTION: Corneal foreign bodies are reported to be the second most common type of ocular injury. Anterior segment optical coherence tomography (AS-OCT) is a valuable tool for the early diagnosis and monitoring the progress of treatment in cases of ocular trauma. Herein we aimed to report on a patient with an intra-corneal foreign body and the role of AS-OCT in management. CASE PRESENTATION: A 34-year-old male presented with foreign body sensation in his left eye...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27628587/corneal-thickening-and-central-flattening-induced-by-femtosecond-laser-hyperopic-shaped-intrastromal-lenticule-implantation
#14
Leonardo Mastropasqua, Mario Nubile
PURPOSE: To investigate the feasibility of the procedure and the modifications of the corneal curvature and profile obtained with a novel technique of stromal-lentoid implantation in ex vivo human corneas. DESIGN: Experimental ex vivo study in human corneas. MATERIALS AND METHODS: Twelve stromal lentoids were produced by means of hyperopic femtosecond lenticule extraction (FLEx) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a refractive power of +8...
September 15, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27621780/mini-scleral-contact-lens-for-management-of-poor-visual-outcomes-after-intrastromal-corneal-ring-segments-implantation-in-keratoconus
#15
Fatemeh Alipour, Firoozeh Rahimi, Mohammad Naser Hashemian, Zahra Ajdarkosh, Ramak Roohipoor, Masoumeh Mohebi
PURPOSE: To evaluate the feasibility and efficacy of mini-scleral design (MSD) contact lenses to treat keratoconus patients who were unsatisfied with the results of corneal inlay. METHODS: In this prospective interventional case series, 9 eyes of 6 keratoconus patients who were unsatisfied with the results of corneal inlay were fitted with MSD contact lenses. Demographic data, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), and higher order aberrations (HOAs) were evaluated before contact lens fitting...
July 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27610242/intrastromal-injection-of-bevacizumab-in-the-management-of-corneal-neovascularization-about-25-eyes
#16
Belghmaidi Sarah, Hajji Ibtissam, Baali Mohammed, Soummane Hasna, Moutaouakil Abdeljalil
Introduction. Corneal neovessels are a major risk factor for corneal graft rejection, due to the loss of the immune privilege. The purpose of this study is to evaluate the effectiveness of intrastromal injection of bevacizumab in the treatment of corneal neovascularization. Material and Methods. This is a prospective study that included 25 eyes of 22 patients with deep corneal neovessels, treated with intrastromal injections of bevacizumab. Results. The average age of patients was 31 years ranging from 16 to 44 years...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27577867/cornea-lymphatics-drive-the-cd8-t-cell-response-to-herpes-simplex-virus-1
#17
Hem R Gurung, Meghan M Carr, Daniel J J Carr
Herpes simplex virus-1 (HSV-1) infection of the cornea induces vascular endothelial growth factor A (VEGF-A)-dependent lymphangiogenesis. However, the extent to which HSV-1-induced corneal lymphangiogenesis impacts the adaptive immune response has not been characterized. Here, we used floxed VEGF-A mice to study the importance of newly created corneal lymphatic vessels in the host adaptive immune response to infection. Whereas the mice infected with the parental virus (strain SC16) exhibited robust corneal lymphangiogenesis, mice that received the recombinant virus (SC16 ICP0-Cre) that expresses Cre recombinase under the control of infected cell protein 0 (ICP0), an HSV-1 immediate-early gene, showed a significant reduction in lymphangiogenesis...
October 4, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27535731/penicillium-keratitis-in-a-hiv-infected-patient
#18
Orapin Anutarapongpan, Onsiri Thanathanee, Olan Suwan-Apichon
A 36-year-old HIV-positive man presented with symptoms of redness, blurred vision and foreign body sensation in his right eye for 3 months. The slit lamp examination revealed deep stromal infiltration with a feathery margin in an otherwise minimal anterior chamber reaction. A corneal scraping was negative. Confocal microscopy demonstrated an abnormal large hyper-reflective oval shape in the corneal stroma. Corneal infiltration did not show improvement after topical, intrastromal and intracameral antifungal treatment...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27531111/-the-histopathological-observation-of-rabbit-corneas-after-small-incision-lenticule-extraction
#19
Z X Dong, L He, Z Y Sun, Y Shen, R Y Chu, X T Zhou
OBJECTIVE: To evaluate the morphological changes during corneal wound healing after small incision lenticule extraction (SMILE). METHODS: Twenty-one New Zealand white rabbits were randomly divided into 2 groups (group A of 12 rabbits and group B of 9 rabbits) using the toss of a coin. All the right eyes were treated. Group A underwent SMILE, and group B underwent femtosecond laser-assisted in situ keratomileusis (LASIK), with the same refractive corrections of-6...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27492109/clinical-outcomes-of-small-incision-lenticule-extraction-and-femtosecond-laser-assisted-wavefront-guided-laser-in%C3%A2-situ%C3%A2-keratomileusis
#20
REVIEW
David P Piñero, Miguel A Teus
UNLABELLED: Small-incision lenticule extraction and wavefront-guided femtosecond-assisted laser in situ keratomileusis (LASIK) provide good visual outcomes and an efficacious correction of myopia or myopic astigmatism with similar levels of safety. Some differences in predictability and the percentage of eyes gaining lines of corrected distance visual acuity are present. A higher level of coma is present after small-incision lenticule extraction, with no clear differences between techniques in spherical aberration...
July 2016: Journal of Cataract and Refractive Surgery
keyword
keyword
104455
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"