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https://www.readbyqxmd.com/read/29149239/label-free-in-vivo-imaging-of-corneal-lymphatic-vessels-using-microscopic-optical-coherence-tomography
#1
Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods: Corneal neovascularization was induced by intrastromal placement of 11...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29135710/adjustment-of-intrastromal-corneal-ring-segments-after-unsuccessful-implantation-in-keratoconic-eyes
#2
Tiago Monteiro, José Ferreira Mendes, Fernando Faria-Correia, Nuno Franqueira, David Madrid-Costa, José F Alfonso
PURPOSE: To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. METHODS: A retrospective nonrandomized case series was conducted including consecutive eyes of patients with keratoconus that underwent ICRS adjustment after an unsuccessful visual outcome...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29135605/novel-method-to-detect-corneal-lymphatic-vessels-in-vivo-by-intrastromal-injection-of-fluorescein
#3
Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
PURPOSE: Corneal lymphatic vessels are clinically invisible because of their thin walls and clear lymph fluid. There is no easy and established method for in vivo imaging of corneal lymphatic vessels so far. In this study, we present a novel approach to visualize corneal lymphatic vessels in vivo by injecting intrastromal fluorescein sodium. METHODS: Six- to eight-week-old female BALB/c mice were used in the mouse model of suture-induced corneal neovascularization...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29128534/development-of-gelatin-ascorbic-acid-cryogels-for-potential-use-in-corneal-stromal-tissue-engineering
#4
Li-Jyuan Luo, Jui-Yang Lai, Shih-Feng Chou, Yi-Jen Hsueh, David Hui-Kang Ma
To offer an ideal hospitable environment for corneal keratocyte growth, the carrier materials can be functionalized with incorporation of signaling molecules to regulate cell biological events. This study reports, for the first time, the development of gelatin/ascorbic acid (AA) cryogels for keratocyte carriers in vitro and in vivo. The cryogel samples were fabricated by blending of gelatin with varying amounts of AA (0-300 mg) and carbodiimide cross-linking via cryogelation technique. Hydrophilic AA content in the carriers was found to significantly affect cross-linking degree and pore dimension of cryogels, thereby dictating their mechanical and biological stability and AA release profile...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29121878/comparison-of-femtosecond-laser-assisted-corneal-intrastromal-xenotransplantation-and-the-allotransplantation-in-rhesus-monkeys
#5
He Jin, Liangping Liu, Hui Ding, Miao He, Chi Zhang, Xingwu Zhong
BACKGROUND: In our previous study, we showed that both allogeneic and autogeneic small-incision femtosecond laser-assisted corneal intrastromal transplantation are safe and effective surgeries. However, the results of small-incision femtosecond laser-assisted intrastromal xenotransplantation have not yet been explored. Additionally, we suggest that glycerol-dehydrated corneal lamellae might provide a possible alternative for this xenogenic implantation approach. METHODS: Corneal inlay lamellae were produced from rabbits and humans using femtosecond laser-assisted surgeries and were dehydrated in glycerol for 1 week at 4 °C...
November 9, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29120710/femtosecond-laser-implantation-of%C3%A2-a%C3%A2-340-degree-intrastromal-corneal-ring%C3%A2-segment-in-keratoconus-short-term%C3%A2-outcomes
#6
Mohammad Mehdi Sadoughi, Bahram Einollahi, Amir Reza Veisi, Mohammad Zare, Mohammad Reza Sedaghat, Danial Roshandel, Neda Einollahi, Javad Rezaei
PURPOSE: To evaluate the short-term outcomes of femtosecond laser-assisted implantation of a 340-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus. SETTING: Four centers in Iran. DESIGN: Prospective case series. METHODS: All cases had implantation of the 340-degree ICR after tunnel creation with a femtosecond laser. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, sphere, cylinder, manifest refraction spherical equivalent (MRSE), mean keratometry (K), steep K, and flat K were evaluated preoperatively and 1, 3, and 6 months postoperatively...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120709/microscope-integrated-intraoperative-optical-coherence-tomography-guided-small-incision-lenticule-extraction-new-surgical-technique
#7
Namrata Sharma, Jayanand Urkude, Manthan Chaniyara, Jeewan S Titiyal
We describe the surgical technique of microscope-integrated intraoperative optical coherence tomography (OCT)-guided small-incision lenticule extraction. The technique enables manual tracking of surgical instruments and identification of the desired dissection plane. It also helps discern the relation between the dissector and the intrastromal lenticule. The dissection plane becomes hyperreflective on dissection, ensuring complete separation of the intrastromal lenticule from the overlying and underlying stroma...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29117420/intraoperative-optical-coherence-tomography-guided-management-of-cap-lenticule-adhesion-during-smile
#8
Jayanand Urkude, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To report successful lenticule extraction using intraoperative optical coherence tomography (OCT) in a case of cap-lenticule adhesion during small incision lenticule extraction (SMILE). METHODS: Case report. RESULTS: A 22-year-old patient with a refractive error of -5.00 -0.50 × 120° and -5.00 -0.75 × 60° in the right and left eyes, respectively, was scheduled for SMILE. The lenticule was created using the VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany)...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29117419/secondary-lenticule-remnant-removal-after-smile
#9
Alex L K Ng, Peter S K Kwok, Tommy C Y Chan
PURPOSE: The authors report four cases of residual intrastromal lenticule after seemingly uneventful small incision lenticule extraction (SMILE) surgery and the outcome after a secondary procedure to remove the lenticule remnant. METHODS: Case reports. RESULTS: All four cases presented with suboptimal corrected distance visual acuity (CDVA) and refractive surprise. Irregularities in the corneal curvature and elevation were detected on corneal topography and tomography...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29097211/infectious-crystalline-keratopathy
#10
REVIEW
Ashley J Porter, Graham A Lee, Albert S Jun
Infectious crystalline keratopathy (ICK) was first reported by Gorovoy et al in 1983 when they identified bacteria colonizing a cornea after a penetrating keratoplasty. Subsequent cases have elaborated on the organisms responsible and the management outcomes. Patients present with a white or grey branching opacity originating from an epithelial defect, commonly after a penetrating keratoplasty. Local immunosuppression contributes to the quiescent nature and the limited inflammatory response associated with ICK...
October 30, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28991336/four-stage-procedure-for-keratoconus-icrs-implantation-corneal-cross-linking-toric-phakic-intraocular-lens-implantation-and-topography-guided-photorefractive-keratectomy
#11
Efekan Coskunseven, Daya Papalkar Sharma, Michael A Grentzelos, Onurcan Sahin, George D Kymionis, Ioannis Pallikaris
PURPOSE: To evaluate a four-stage combined treatment for keratoconus including intrastromal corneal ring segment (ICRS) implantation followed by corneal cross-linking (CXL), toric phakic intraocular lens (IOL) implantation, and topography-guided photorefractive keratectomy (TG-PRK). METHODS: In this retrospective interventional case series, 11 eyes of 7 patients with progressive keratoconus were treated with a four-stage procedure including the following: Keraring ICRS (Mediphacos Ltda, Belo Horizonte, Brazil) implantation followed by CXL, phakic IOL implantation, and TG-PRK (minimum 6 months between each stage)...
October 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28976414/adjuvant-stromal-amphotericin-b-injection-for-late-onset-dmek-infection
#12
Elmer Y Tu, Parag A Majmudar
PURPOSE: To report the successful medical management of a late-onset Descemet membrane endothelial keratoplasty (DMEK)-related interface infection. METHODS: A case of DMEK endothelial keratoplasty-related infection treated with intrastromal antifungal injection was identified. The following information was collected: demographic data, surgical indications, donor rim cultures, donor mate outcomes, clinical course, diagnostic tests, and clinical outcome. RESULTS: A DMEK patient developed a single infiltrate approximately 1 month after uncomplicated DMEK...
December 2017: Cornea
https://www.readbyqxmd.com/read/28961565/cataract-surgery-in-eyes-with-keratoconus-a-review-of-the-current-literature
#13
Majid Moshirfar, Brian D Walker, Orry C Birdsong
PURPOSE OF REVIEW: There are an increasing number of keratoconic eyes, requiring cataract surgery. We review the preoperative planning, intraoperative options, and postoperative management that aid in successful outcomes. RECENT FINDINGS: Management of keratoconic eyes requiring cataract surgery requires a multifaceted approach. Preoperatively, corneal crosslinking and intrastromal corneal ring segments can be considered in order to provide stable keratometry values for intraocular lens (IOL) calculations...
September 28, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28957978/evaluation-of-the-reliability-and-repeatability-of-scheimpflug-system-measurement-in-keratoconus
#14
Beatriz de Luis Eguileor, Julene Escudero Argaluza, Jose Ignacio Pijoán Zubizarreta, Alaitz Santamaria Carro, Jaime Etxebarria Ecenarro
PURPOSE: To assess the reliability and repeatability of the parameters obtained using a Scheimpflug system (Pentacam HR-high resolution) for monitoring progression in eyes with keratoconus. METHODS: A prospective study was conducted based on measurements taken with the Pentacam HR in 82 eyes with keratoconus. We calculated the intraclass correlation coefficient (ICC) and the repeatability limit for topographic and aberrometric parameters. RESULTS: All the parameters analyzed had excellent ICCs, above 0...
September 26, 2017: Cornea
https://www.readbyqxmd.com/read/28951784/intrastromal-corneal-ring-segments-for-astigmatism-correction-after-deep-anterior-lamellar-keratoplasty
#15
Júlio C D Arantes, Sandro Coscarelli, Paulo Ferrara, Luana P N Araújo, Marcos Ávila, Leonardo Torquetti
Background. To evaluate the change in corneal astigmatism after intrastromal corneal ring segment (ICRS) implantation in keratoconus patients with previous deep anterior lamellar keratoplasty (DALK). Design was a longitudinal, retrospective, interventional study. The study included 25 eyes of 24 patients with keratoconus who had DALK performed at least two years prior to ICRS implantation. All patients had a clear corneal graft with up to 8.00 D of corneal astigmatism and intolerance to contact lenses. The studied parameters were age, sex, corrected distance visual acuity (CDVA), maximum keratometry (K1), minimum keratometry (K2), spherical equivalent, and astigmatism...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28948045/long-term-follow-up-of-intrastromal-corneal-ring-segments-in-paracentral-keratoconus-with-coincident-corneal-keratometric-comatic-and-refractive-axes-stability-of-the-procedure
#16
Luis Fernández-Vega Cueto, Carlos Lisa, David Madrid-Costa, Jesús Merayo-Lloves, José F Alfonso
PURPOSE: To assess the long-term outcomes of implanting intrastromal corneal ring segments (ICRS) in paracentral keratoconic eyes. METHODS: 58 eyes with paracentral keratoconus with coincident refractive, keratometric, and comatic axes were evaluated. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity and refractive errors were recorded before and at all follow-up visits. The postoperative follow-up was 5 years. Patients were divided into two groups: group I (30 years old or younger) and group II (more than 30 years old)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#17
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28926886/-keratectomy-combined-with-intrastromal-injection-of-voriconazole-in-treating-fungal-keratitis
#18
S X Li, J Biang, X Li, L T Zhang, W Y Shi
Objective: To investigate the treatment effect of keratectomy combined with intrastromal injection of voriconazole on fungal keratitis. Methods: Retrospective study. Ninety-eight fungal keratitis patients (98 eyes) were treated by keratectomy combined with intrastromal injection of voriconazole in Shandong Eye Hospital from January 2013 to May 2015. The corneal ulcers were mostly located in the paracentral or peripheral cornea, which incompletely blocked the pupil area. Slit lamp and anterior segment optical coherence tomography (AS-OCT) were used for lesion detection...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28913508/confocal-biomicroscopic-changes-of-the-corneal-layers-following-femtosecond-laser-assisted-myoring-implantation-in-keratoconus
#19
Heidar Siatiri, Mahmoud Jabbarvand, Mehrdad Mohammadpour, Amirhossein Mollazadeh, Nasim Siatiri, Arash Mirmohammadsadeghi
PURPOSE: To evaluate the effect of the femtosecond laser-assisted MyoRing implantation on the confocal biomicroscopic findings in different corneal layers of the patients with keratoconus. METHODS: Twelve eyes of 12 patients with mild to moderate keratoconus (keratometry between 48 and 52 diopters) and intolerance to hard contact lens entered the study. All the included patients underwent femtosecond laser-assisted MyoRing (Dioptex GmBH, Linz, Austria) implantation...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28880337/effect-of-lowering-laser-energy-on-the-surface-roughness-of-human-corneal-lenticules-in-smile
#20
Yong Woo Ji, Minseo Kim, David Sung Yong Kang, Dan Z Reinstein, Timothy J Archer, Jin Young Choi, Eung Kweon Kim, Hyung Keun Lee, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To determine the effect of lowering femtosecond laser energy on the surface quality of the intrastromal interface during small incision lenticule extraction (SMILE). METHODS: Forty age- and diopter-matched female patients (40 eyes) with moderate myopia received SMILE with different energy levels (100 to 150 nJ) and fixed spot separation (4.5 μm). Five human corneal lenticules from each energy group were evaluated by atomic force microscopy and scanning electron microscopy (SEM)...
September 1, 2017: Journal of Refractive Surgery
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