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https://www.readbyqxmd.com/read/28620706/complete-corneal-ring-myoring-implantation-versus-myoring-implantation-combined-with-corneal-collagen-crosslinking-for-keratoconus-3-year-follow-up
#1
Guzel Bikbova, Gyulli Kazakbaeva, Mukharram Bikbov, Emin Usubov
PURPOSE: To estimate the effectiveness of complete corneal ring (MyoRing) implantation compared with MyoRing implantation combined with corneal collagen crosslinking (CXL) for keratoconus treatment for 36 months follow-up. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: MyoRing implantation was performed in a series of 78 patients (80 eyes) with keratoconus II-III Amsler classification, of these 39 eyes had MyoRing implantation combined with CXL...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28617727/descemet-s-membrane-dehiscence-resulting-from-misdirected-viscoelastic-during-anterior-chamber-reformation
#2
Edward Chay, Ghulam Dastgir, Wayne Scott, Douglas Lazzaro
We report a case of Descemet's membrane detachment after inadvertent intrastromal injection of hyaluronic acid. Surgical removal was attempted with minimal but slow improvement. Near-complete resolution occurred with subsequent conservative management within 6 weeks.
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28602335/neodymium-yag-laser-posterior-capsulotomy-in-eye-with-an-intrastromal-inlay
#3
Phillip C Hoopes, Jordan D Desautels, Majid Moshirfar, Steven H Linn, Nick Mamalis
We report intraoperative issues, patient outcomes, and lessons learned from inadvertently contacting a Kamra corneal inlay with a neodymium:YAG (Nd:YAG) laser during a routine capsulotomy procedure for posterior capsule opacification. We also present scanning electron microscopic and histopathologic images from a series of 4 inlays implanted in postmortem porcine eyes that were purposely contacted with an Nd:YAG laser. Our capsulotomy patient developed a clinically insignificant and transient corneal opacity accompanied by mild blanching on the inlay...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28602332/assessment-of-stromal-riboflavin-concentration-depth-profile-in-nanotechnology-based-transepithelial-corneal-crosslinking
#4
Giuseppe Lombardo, Norberto Liborio Micali, Valentina Villari, Nancy Leone, Sebastiano Serrao, Dario Rusciano, Marco Lombardo
PURPOSE: To determine the intrastromal concentration of riboflavin in nanotechnology-based transepithelial corneal crosslinking. SETTING: Consiglio Nazionale delle Ricerche, Messina, Italy. DESIGN: Experimental study. METHODS: Six human donor sclerocorneal tissues were used to evaluate penetration of nanotechnology-based riboflavin 0.1% solution in the stroma through the intact epithelium. Three additional tissues were deepithelialized and soaked with dextran 20...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28503064/combined-intrastromal-injection-of-amphotericin-b-and-topical-fluconazole-in-the-treatment-of-resistant-cases-of-keratomycosis-a-retrospective-study
#5
Waled Mahdy Nada, Mahmoud A Al Aswad, Wael M El-Haig
PURPOSE: To evaluate the efficacy of combination therapy of a single intrastromal injection of amphotericin B and topical fluconazole in resistant cases of fungal keratitis, and also topical amphotericin B as monotherapy in terms of the duration of the recovery period and toxic drug effects. METHODS: This retrospective 2-year study reviewed 68 cases of unilateral fungal keratitis diagnosed by clinical features and positive laboratory culture results. Forty-one cases were resistant and did not respond to monotherapy with an antifungal agent...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28486314/cellular-therapy-with-human-autologous-adipose-derived-adult-stem-cells-for-advanced-keratoconus
#6
Jorge L Alió Del Barrio, Mona El Zarif, María P de Miguel, Albert Azaar, Norman Makdissy, Walid Harb, Ibrahim El Achkar, Francisco Arnalich, Jorge L Alió
PURPOSE: The aim of this phase 1 study was to preliminarily evaluate the safety and efficacy of autologous adipose-derived adult stem cell (ADASC) implantation within the corneal stroma of patients with advanced keratoconus. METHODS: Five consecutive patients were selected. Autologous ADASCs were obtained by elective liposuction. ADASCs (3 × 10) contained in 1 mL saline were injected into the corneal stroma through a femtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia...
May 8, 2017: Cornea
https://www.readbyqxmd.com/read/28485528/bioengineered-keratocyte-spheroids-fabricated-on-chitosan-coatings-enhance-tissue-repair-in-a-rabbit-corneal-stromal-defect-model
#7
Shih-Feng Chou, Chih-Hung Lee, Jui-Yang Lai
Cultivated cell spheroid transplantation is widely studied as a means of facilitating tissue regeneration. Chitosan biomaterial has been shown to promote keratocyte aggregation and multicellular spheroid formation. Herein, we provide further evidence on application of bioengineered keratocyte spheroids for corneal stromal tissue engineering. In an allogeneic rabbit model of stromal destruction caused by bacterial keratitis, the corneas were intrastromally injected with isolated keratocyte suspensions or aggregated spheroid grafts at same cell number...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28421398/supradescemetic-voriconazole-injection-for-candida-parapsilosis-keratitis
#8
Nikolaos Mamas, Konstantinos Andreanos, Klio Chatzistefanou, Petros Petrou, Dimitrios Brouzas, George Kymionis, Chrysanthi Koutsandrea, Konstantinos Droutsas
PURPOSE: To describe a technique for intracorneal application of voriconazole into the supradescemetic space in a case of deep recalcitrant Candida parapsilosis keratitis of a penetrating cornea graft. METHODS: A deep intracorneal incision reaching the center of the corneal infiltrate was created with a 20-gauge MVR blade. Then, a 27-gauge hydrodissection cannula was inserted deep into the corneal pocket, and 0.1 ml of voriconazole 0.5 mg/ml was injected until a bullous detachment of Descemet membrane (DM) covered 1/3 of the graft's area...
April 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28412070/evaluation-of-femtosecond-laser-intrastromal-incision-location-using-optical-coherence-tomography
#9
Li Wang, Lai Jiang, Katie Hallahan, Zaina N Al-Mohtaseb, Douglas D Koch
PURPOSE: To use optical coherence tomography (OCT) to evaluate the femtosecond laser intrastromal incisions made during cataract surgery to reduce corneal astigmatism. DESIGN: Retrospective case series. PARTICIPANTS: Seventy-seven eyes of 77 patients. METHODS: Paired intrastromal incisions were created using the Catalys femtosecond laser (Abbott Medical Optics, Inc., Santa Ana, CA). The planned intrastromal incision parameters were 20% uncut anterior, 20% uncut posterior, midpoint depth of 50%, and 90° side cut angle...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28366374/sequential-intrastromal-corneal-ring-segment-and-monofocal-intraocular-lens-implantation-for-keratoconus-and-cataract-long-term-follow-up
#10
José F Alfonso, Carlos Lisa, Luis Fernández-Vega Cueto, Arancha Poo-López, David Madrid-Costa, Luis Fernández-Vega
PURPOSE: To evaluate the efficacy, safety, predictability, and stability of sequential Ferrara intrastromal corneal ring segment (ICRS) and intraocular lens (IOL) implantation in patients with keratoconus and cataract. SETTING: Fernández-Vega Ophthalmological Institute, Oviedo, Spain. DESIGN: Retrospective case series. METHODS: This study comprised patients with keratoconus and cataract who had ICRS implantation followed 6 months later by IOL implantation...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28360537/successful-treatment-of-chrysosporium-keratitis-with-voriconazole
#11
Onsiri Thanathanee, Chavakij Bhoomibunchoo, Orapin Anutarapongpan, Olan Suwan-Apichon, Yosanan Yospaiboon
OBJECTIVE: To report a patient with severe Chrysosporium keratitis successfully treated by voriconazole. METHOD: Case report. RESULTS: A 37-year-old healthy male presented with irritation, pain and reduced vision in his left eye after mud contamination. Examination demonstrated corneal stromal infiltration, endothelial plaque and hypopyon. Corneal scrapings demonstrated numerous septate hyphae, and specimen cultures were positive for Chrysosporium sp...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28359626/effects-of-femtosecond-and-excimer-lasers-on-implanted-kamra-corneal-inlay-in-animal-models
#12
F K Sammouh, T A Baban, W N Dandan, E L Warrak
PURPOSE: To evaluate the effect of femtosecond laser and excimer laser on an intracorneal inlay (KAMRA(®)) implanted in animal models. METHODS: Femtosecond laser was used to create corneal intrastromal pockets at 250μm depth in five porcine eyes. Four intact KAMRA inlays, examined by slit-lamp biomicroscopy and light microscopy, were implanted in the pocket of four eyes. A standard LASIK flap was created above each implanted inlay in the four eyes using a femtosecond laser with flap thicknesses of 150μm, 130μm, 110μm and 90μm...
May 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28346009/reactions-with-antisera-and-pathological-effects-of-staphylococcus-aureus-gamma-toxin-in-the-cornea
#13
Michael A Bierdeman, Angela M Torres, Armando R Caballero, Aihua Tang, Richard J O'Callaghan
PURPOSE: This study analyzed the toxicity of purified gamma-toxin from Staphylococcus aureus and the protectiveness of antisera to gamma-toxin in the rabbit cornea. MATERIALS AND METHODS: Gamma-toxin was purified from cultures of alpha-toxin deficient S. aureus strain Newman Δhla. Antisera to native gamma-toxin (Hlg) were produced in rabbits. These antisera and a commercial polyclonal antibody to recombinant HlgB (rHlgB) were analyzed for specificity and toxin neutralization...
March 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28261495/keraring-intrastromal-segment-depth-measured-by-spectral-domain-optical-coherence-tomography-in-eyes-with-keratoconus
#14
Ugo de Sanctis, Carlo Lavia, Marco Nassisi, Savino D'Amelio
Purpose. To evaluate agreement between measured and intended distance of Keraring (Mediphacos, Belo Horizonte, Brazil) intracorneal ring segments from the anterior and posterior corneal surfaces. Methods. Twenty-six Keraring ICRS implanted in 24 keratoconic eyes were examined. The distance from the Keraring apex to the anterior corneal surface and the distance from the inner and the outer corners to the posterior corneal surface were measured 3 months postoperatively using spectral-domain optical coherence tomography...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28253401/netrin-4-mediates-corneal-hemangiogenesis-but-not-lymphangiogenesis-in-the-mouse-model-of-suture-induced-neovascularization
#15
Anna-Karina B Maier, Sabrina Klein, Norbert Kociok, Aline I Riechardt, Enken Gundlach, Nadine Reichhart, Olaf Strauß, Antonia M Joussen
Purpose: Netrin-4, a secreted protein, is found in the basement membrane of blood vessels and acts as a key regulator of angiogenesis. Here we investigated the role of Netrin-4 in the mouse-model of suture-induced corneal hem- and lymphangiogenesis. Methods: Corneal hem- and lymphangiogenesis were induced in Netrin-4-deficient (Ntn4-/-) and wild-type (WT) mice by placing three 11-0 nylon sutures intrastromally. Fourteen days after suturing, the vascularized area was analyzed via corneal flat mount immunohistochemistry...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28210183/intraocular-lens-power-overestimation-in-a-patient-with-history-of-circling-keratorraphy
#16
Vasilios F Diakonis, Nilufer Yesilirmak, George D Kymionis, Sonia H Yoo
We report a case of cataract extraction and intraocular lens (IOL) power overestimation in a patient with history of hyperopia managed with circling keratorraphy. A 65-year-old female presented to our institute complaining of decreased vision in both eyes. The patient had a history of bilateral hyperopia that was managed 20 years ago (1994) with circling keratorraphy. At presentation her uncorrected distance visual acuity (UDVA) was 20/70 and 20/60 in her right eye (OD) and left eye (OS), respectively, while her corrected distance visual acuity (CDVA) was 20/25 OD and 20/25 OS with manifest refraction of -0...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28192590/tomographic-findings-after-implantation-of-ferrara-intrastromal-corneal-ring-segments-in-keratoconus
#17
João Marcelo Lyra, Daniela Lyra, Guilherme Ribeiro, Leonardo Torquetti, Paulo Ferrara, Aydano Machado
PURPOSE: To analyze and compare changes to the anterior and posterior corneal surfaces after Ferrara intracorneal ring segment (ICRS) (AJL, Boecillo, Spain) implantation and to correlate those changes with visual outcomes. METHODS: This retrospective case series study comprised consecutive patients with keratoconus implanted with the Ferrara ICRS. Computed tomography scans of the two corneal surfaces were obtained preoperatively and postoperatively with a rotating Scheimpflug imaging system...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28135748/-historical-overview-of-the-clinical-development-of-the-small-incision-lenticule-extraction-surgery-smile
#18
M Blum, K S Kunert, W Sekundo
The clinical use of femtosecond lasers has led to significant progress in the quality of refractive surgery. SMILE femtosecond laser surgery (SMILE: Small Incision Lenticule Extraction) permits the first one step intrastromal laser procedure without a flap. This article describes the gradual development of this surgery during the last ten years.
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28125853/post-lens-tear-turbidity-and-visual-quality-after-scleral-lens-wear
#19
Gonzalo Carracedo, Maria Serramito-Blanco, Alba Martin-Gil, Zicheng Wang, Candela Rodriguez-Pomar, Jesús Pintor
BACKGROUND: The aim was to evaluate the turbidity and thickness of the post-lens tear layer and its effect on visual quality in patients with keratoconus after the beginning of lens wear and before lens removal at the end of eight hours. METHODS: Twenty-six patients with keratoconus (aged 36.95 ± 8.95 years) participated voluntarily in the study. The sample was divided into two groups: patients with intrastromal corneal ring (ICRS group) and patients without ICRS (KC group)...
January 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28096650/refractive-and-visual-outcomes-after-keraring-intrastromal-corneal-ring-segment-implantation-for-keratoconus-assisted-by-femtosecond-laser-at-6-months-follow-up
#20
Mohamed A Heikal, Marwa Abdelshafy, Tarek T Soliman, Abdelmonem M Hamed
PURPOSE: We attempted to evaluate the efficacy of femtosecond laser-assisted intrastromal corneal ring segment implantation in patients with keratoconus (KC). PATIENTS AND METHODS: A retrospective interventional consecutive clinical study was conducted on patients with KC who were treated with femtosecond laser Keraring implantation. All procedures were performed at Ebsar Eye Center in the period from January 5, 2015, to February 28, 2016. RESULTS: Thirty eyes of 20 patients were included in this study...
2017: Clinical Ophthalmology
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