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https://www.readbyqxmd.com/read/29778107/photorefractive-intrastromal-corneal-crosslinking-for-treatment-of-myopic-refractive-error-findings-from-12-month-prospective-study-using-an-epithelium-off-protocol
#1
Matthias Elling, Inga Kersten-Gomez, H Burkhard Dick
PURPOSE: To assess the long-term effectiveness and safety of photorefractive intrastromal corneal crosslinking (CXL) in patients with low myopia. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective case series. METHODS: Healthy eyes with myopia were treated with photorefractive intrastromal CXL using the Mosaic System. Riboflavin 0.1% solution (VibeX Rapid) was topically administered, followed by 365 nm ultraviolet-A (30 mW/cm2 ) irradiance...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29738584/corneal-allogenic-intrastromal-ring-segments-cairs-combined-with-corneal-cross-linking-for-keratoconus
#2
Soosan Jacob, Shaila R Patel, Amar Agarwal, Arvind Ramalingam, A I Saijimol, John Michael Raj
PURPOSE: To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS). METHODS: CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser-dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)-either conventional or contact lens-assisted CXL (A-CACXL), depending on minimum corneal thickness...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29728290/posterior-cornea-and-thickness-changes-after-scleral-lens-wear-in-keratoconus-patients
#3
Maria Serramito, Carlos Carpena-Torres, Jesús Carballo, David Piñero, Michael Lipson, Gonzalo Carracedo
PURPOSE: To evaluate the changes in the corneal thickness, anterior chamber depth and posterior corneal curvature and aberrations after scleral lens wear in keratoconus patients with and without intrastromal corneal ring segments (ICRS). METHODS: Twenty-six keratoconus subjects (36.95 ± 8.95 years) were evaluated after 8 h of scleral lens wear. The subjects were divided into two groups: those with ICRS (ICRS group) and without ICRS (KC group). The study variables evaluated before and immediately after scleral lens wear included corneal thickness evaluated in different quadrants, posterior corneal curvature at 2, 4, 6 and 8 mm of corneal diameter, posterior corneal aberrations for 4, 6 and 8 mm of pupil size and anterior chamber depth...
May 1, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29670766/corneal-debridement-combined-with-intrastromal-voriconazole-for-recalcitrant-fungal-keratitis
#4
Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng
Background: To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. Methods: This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50  μ g/0.1 ml). This paper reviews and analyzes the patients' basic state, surgical intervention, medicinal treatment, and outcomes. Results: The mean sizes of infiltration and ulcer were (5...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29625453/substance-p-modulation-of-human-and-murine-corneal-neovascularization
#5
Marco Barbariga, Phillippe Fonteyne, Manoosh Ostadreza, Fabio Bignami, Paolo Rama, Giulio Ferrari
Purpose: The purpose of this study was to investigate the role of substance P (SP) in patients affected with corneal neovascularization (CNV) and in three different Tac1-knockout (KO) murine models of CNV. Methods: SP levels in tears were measured with a multiplex bead assay. The extent of human CNV was quantified as number of affected corneal quadrants. Murine CNV was induced in both strains by means of total disepithelization, alkali burn, and intrastromal sutures...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29615397/deep-anterior-lamellar-keratoplasty-dissection-plane-with-viscoelastic-and-air-can-be-different
#6
Andrew R Ross, Dalia G Said, Abdalla El-Amin, Saif Altaan, Javier Cabrerizo, Mario Nubile, Emily Hogan, Leonardo Mastropasqua, Harminder Singh Dua
AIMS: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty. METHODS: Intrastromal injections of 0.1 and 0.3 mL of sodium hyaluronate 1.2% and 0.6% were made into sclera-corneal discs (n = 32) at superficial (anterior-third), midstromal (middle-third) and deep (posterior-third) levels to simulate deep anterior lamellar keratoplasty. Postinjection optical coherence tomograms (OCT) were obtained with the needle in situ...
April 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29610025/comparative-study-of-3-intracorneal-implant-types-to-manage-central-keratoconus
#7
Mohamed Omar Yousif, Azza Mohamed Ahmed Said
PURPOSE: To compare the visual acuity, refraction, corneal topography, and corneal asphericity of intrastromal corneal implantation of Keratacx 160-degree 2 symmetrical ring segment, the Keratacx 320-degree near-total ring, and the Myoring continuous intracorneal ring (ICR) in central keratoconus. SETTING: Ophthalmology Department, Ain Shams University, Cairo, Egypt. DESIGN: Prospective case series. METHODS: Surgeries were performed using a femtosecond laser for tunnel creation for the 160-degree 2-segment device (Group 1) and the 320-degree near-total ring (Group 2), and for pocket creation for the ICR (Group 3)...
March 30, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29594793/sterile-keratitis-after-uneventful-corneal-collagen-cross-linking-in-a-patient-with-axenfeld-rieger-syndrome
#8
Betul Seher Uysal, Derya Yaman, Ozge Sarac, Emine Akcay, Nurullah Cagil
PURPOSE: To report on a keratoconus (KC) patient with Axenfeld-Rieger syndrome (ARS) who developed sterile keratitis after accelerated corneal collagen cross-linking (CXL). METHODS: An 18-year-old patient with ARS and KC who had previously undergone intrastromal ring segment implantation underwent accelerated CXL (9 mW/cm2  UVA intensity for 10 min). RESULTS: After uneventful surgery, the patient presented with severe photophobia, redness of the eye, and decreased vision 72 h following the procedure...
March 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29587975/astigmatic-correction-by-intrastromal-astigmatic-keratotomy-during-femtosecond-laser-assisted-cataract-surgery-factors-in-outcomes
#9
Yong-Soo Byun, Seonjoo Kim, Marjorie Z Lazo, Mi-Hyun Choi, Min-Ji Kang, Jee-Hye Lee, Young-Sik Yoo, Woong-Joo Whang, Choun-Ki Joo
PURPOSE: To evaluate the 6-month outcomes of femtosecond laser astigmatic keratotomy (AK) combined with femtosecond laser-assisted cataract surgery and identify factors affecting the efficacy of astigmatic correction. SETTING: Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, South Korea. DESIGN: Retrospective case series. METHODS: Femtosecond laser AK was performed during femtosecond laser-assisted cataract surgery...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29564359/femtosecond-laser-assisted-astigmatic-keratotomy-a-review
#10
REVIEW
John S M Chang
Background: Astigmatic keratotomy (AK) remains an accessible means to correct surgically induced or naturally occurring astigmatism. The advantages of femtosecond laser-assisted astigmatic keratotomy (FSAK) over conventional methods have been recognized recently. Main text: This review evaluates the efficacy, complications, and different methods of FSAK for correction of astigmatism in native eyes and those that underwent previous penetrating keratoplasty (PKP)...
2018: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/29563700/fungal-keratitis-and-endophthalmitis-after-implantation-of-type-1-keratoprosthesis
#11
Chintan Malhotra, Arun Kumar Jain, Nikhil Aggarwal
A 70-year-old patient who underwent uneventful primary implantation of Auro K Pro (a Type I Boston Keratoprosthesis-based device), developed infiltrates in the deep stroma of the carrier corneal graft and exudates on the optic stem of the keratoprosthesis assembly, 6 weeks postoperatively, which subsequently progressed to endophthalmitis. Vitreous tap was positive for a panfungal polymerase chain reaction, although corneal scrapings for both Gram stain and KOH wet mount yielded negative results. Aggressive management with systemic, topical, intravitreal, and intrastromal antifungal agents resulted in an initial resolution, but residual inflammatory vitreous membranes persisted...
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29543194/-strength-properties-of-rabbit-cornea-after-femtosecond-laser-keratoplasty-with-and-without-different-intracorneal-implants
#12
N P Pashtaev, N A Pozdeeva, V V Zotov, M V Sinitsyn, M A Shcheglova
AIM: to conduct a comparative experimental study of the effect of the use of intracorneal implants during femtosecond laser-assisted intrastromal pocket (IP) and intrastromal tunnel (IT) formation on the strength properties of the cornea. MATERIAL AND METHODS: The experimental study was performed on 24 corneas of 12 rabbit eyes enucleated 1 month after slaughtering. All eyes were divided into 6 groups according to the method of operation. IP and IT were created with IntraLase FS 60 kHz femtolaser...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29527115/tacrolimus-interacts-with-voriconazole-to-reduce-the-severity-of-fungal-keratitis-by-suppressing-ifn-related-inflammatory-responses-and-concomitant-fk506-and-voriconazole-treatment-suppresses-fungal-keratitis
#13
Jing Zhong, Lulu Peng, Bowen Wang, Henan Zhang, Saiqun Li, Ruhui Yang, Yuqing Deng, Haixiang Huang, Jin Yuan
Purpose: To investigate the expression and roles of type I and II interferons (IFNs) in fungal keratitis, as well as the therapeutic effects of tacrolimus (FK506) and voriconazole on this condition. Methods: The mRNA and protein expression levels of type I (IFN-α/β) and II (IFN-γ) IFNs, as well as of related downstream inflammatory cytokines (interleukin (IL)-1α, IL-6, IL-12, and IL-17), were detected in macrophages, neutrophils, lymphocytes, and corneal epithelial cells (A6(1) cells) stimulated with zymosan (10 mg/ml) for 8 or 24 h...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29522229/predictability-of-tunnel-depth-for-intrastromal-corneal-ring-segments-implantation-between-manual-and-femtosecond-laser-techniques
#14
Tiago Monteiro, José F Alfonso, Nuno Franqueira, Fernando Faria-Correia, Renato Ambrósio, David Madrid-Costa
PURPOSE: To compare the predictability of intrastromal tunnel depth creation for intrastromal corneal ring segments (ICRS) implantation between manual dissection and femtosecond laser using a high-resolution anterior segment optical coherence tomography (AS-OCT). METHODS: This multicenter study included patients with keratoconus who had Ferrara-type ICRS implantation at Hospital de Braga using manual dissection and at the Fernandez-Vega Ophthalmological Institute using the femtosecond laser technique...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29451741/non-invasive-optical-method-for-real-time-assessment-of-intracorneal-riboflavin-concentration-and-efficacy-of-corneal-cross-linking
#15
Giuseppe Lombardo, Valentina Villari, Norberto L Micali, Nancy Leone, Cristina Labate, Maria P De Santo, Marco Lombardo
Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV-A corneal cross-linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo-oxidated by UV-A light for generating additional cross-linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported an UV-A theranostic prototype device for performing corneal cross-linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29429144/results-of-ethanol-assisted-epithelium-on-corneal-cross-linking-with-and-without-intrastromal-corneal-ring-implantation
#16
Orhan Ayar, Orkun Muftuoglu, Mehmet Orcun Akdemir, Mehmet Cuneyt Ozmen
PURPOSE: To evaluate the topographic, refractive, and pachymetric changes after ethanol-assisted transepithelial corneal cross-linking (CXL) to stabilize progression of keratoconus (KC). PATIENTS AND METHODS: This study retrospectively evaluated the long-term topographic, refractive, and pachymetric changes in patients diagnosed with KC who underwent corneal cross-linking and/or intrastromal corneal ring segment (ICRS) implantation. The subjects were divided into three groups, corresponding to eyes treated with CXL alone (group 1), CXL and ICRS at the same time (group 2), and CXL after ICRS implantation (group 3)...
February 10, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29426458/deep-anterior-lamellar-keratoplasty-for-an-intrastromal-epithelial-corneal-cyst-a-case-report
#17
Aipeng Li, Yingnan Zhang, Zhiqiang Pan
No abstract text is available yet for this article.
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29416380/keratoconus-treatment-using-femtosecond-assisted-intrastromal-corneal-graft-faiscg-surgery-a-case-series
#18
Khosrow Jadidi, Seyed Aliasghar Mosavi
We describe an intrastromal corneal graft technique that uses femtosecond laser to create a desirable corneal lenticule with precise diameter, depth, and shape as well as an intra-stromal pocket in keratoconus patients. The technique seems to be a feasible and safe treatment option to treat keratoconic eyes with reference to the irregularity and instability of cornea. The technique can be performed easily and appears safe and effective. At 7 days postoperatively, all eyes were white and quiet, and the grafts were clear...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29398901/simultaneous-intratunnel-cross-linking-with-intrastromal-corneal-ring-segment-implantation-versus-simultaneous-epithelium-off-cross-linking-with-intrastromal-corneal-ring-segment-implantation-for-keratoconus-management
#19
Mohamed Hosny, Moustafa Nour, Sarah Azzam, Mohsen Salem, Esraa El-Mayah
Purpose: The purpose of this study is to compare the efficacy of intratunnel cross-linking combined with intrastromal corneal ring segment (ICRS) implantation versus combined epithelium-off (epi-off) cross-linking and ICRS implantation for the management of keratoconus. Methods: Our study included 20 eyes of 12 patients with moderate-to-severe keratoconus. Group A included 10 eyes that underwent simultaneous ICRS implantation with intratunnel cross-linking. Group B included 10 eyes that underwent simultaneous ICRS implantation with epi-off cross-linking...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29390522/delayed-onset-mycobacterium-intracellulare-keratitis-after-laser-in-situ-keratomileusis-a-case-report-and-literature-review
#20
REVIEW
JaeSang Ko, Se Kyung Kim, Dong Eun Yong, Tae-Im Kim, Eung Kweon Kim
RATIONALE: Infectious keratitis is a relatively uncommon but potentially sight-threatening complication of laser in situ keratomileusis (LASIK). Mycobacterial keratitis is usually regarded as late onset keratitis among post-LASIK keratitis. There has been no documented case of Mycobacterium intracellulare post-LASIK keratitis of a long-latent period. PATIENT CONCERNS: A 36-year-old man was referred to our out-patient clinic, for persistent corneal epithelial defect with intrastromal infiltration...
December 2017: Medicine (Baltimore)
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