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https://www.readbyqxmd.com/read/28542088/corneal-breakthrough-haze-after-photorefractive-keratectomy-with-mitomycin-c-incidence-and-risk-factors
#1
Igor Kaiserman, Naʼava Sadi, Michael Mimouni, Tzahi Sela, Gur Munzer, Shmuel Levartovsky
PURPOSE: To identify preoperative and intraoperative factors affecting breakthrough corneal haze incidence after photorefractive keratectomy (PRK) with mitomycin C (MMC). METHODS: In this retrospective study of PRK performed at the Care Vision Refractive Laser Center, Tel Aviv, Israel, a total of 7535 eyes (n = 3854 patients; mean age ± SD, 26 ± 6 years; 55% men) underwent PRK with intraoperative MMC application. Patients with histories of corneal pathology or surgery were excluded...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28529481/topical-ophthalmic-formulation-of-trichostatin-a-and-surr9-c84a-for-quick-recovery-post-alkali-burn-of-corneal-haze
#2
Kislay Roy, Chun Hei Antonio Cheung, Rupinder K Kanwar, Rajat Sandhir, Jagat R Kanwar
Alkali burn injury is a true ocular emergency of the conjunctiva and cornea that requires immediate precision. Lack of an immediate therapy can lead to a substantial damage in the ocular surface and anterior segment further causing visual impairment and disfigurement. We explored the regenerative capability of dominant negative survivin protein (SurR9-C84A) and histone deacetylase inhibitor trichostatin-A (TSA) in vivo, in a rat alkali burn model. A topical insult in rat eyes with NaOH led to degradation of the conjunctival and corneal epithelium...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28513495/effect-of-post-crosslinking-haze-on-the-repeatability-of-scheimpflug-based-and-slit-scanning-imaging-devices
#3
Rohit Shetty, Aarti Agrawal, Rashmi Deshmukh, Luci Kaweri, Harsha L Rao, Harsha Nagaraja, Chaitra Jayadev
PURPOSE: The aim of this study was to analyze the effect of postcollagen crosslinking (CXL) haze on the measurement and repeatability of pachymetry and mean keratometry (Km) of four corneal topographers. MATERIALS AND METHODS: Sixty eyes of sixty patients with progressive keratoconus who had undergone accelerated CXL (ACXL) underwent imaging with a scanning slit imaging device (Orbscan II) and three Scheimpflug imaging devices (Pentacam HR, Sirius, and Galilei)...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495149/united-states-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-keratoconus-treatment
#4
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: Patients with progressive keratoconus (n = 205). METHODS: The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the epithelium. MAIN OUTCOME MEASURES: The primary efficacy criterion was the change over 1 year of topography-derived maximum keratometry value, comparing treatment with control group...
May 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28486725/regeneration-of-defective-epithelial-basement-membrane-and-restoration-of-corneal-transparency-after-photorefractive-keratectomy
#5
Gustavo K Marino, Marcony R Santhiago, Abirami Santhanam, Andre A M Torricelli, Steven E Wilson
PURPOSE: To study regeneration of the normal ultrastructure of the epithelial basement membrane (EBM) in rabbit corneas that had -9.00 D photorefractive keratectomy (PRK) and developed late haze (fibrosis) with restoration of transparency over 1 to 4 months after surgery and in corneas that had incisional wounds. METHODS: Twenty-four rabbits had one of their eyes included in one of the two procedure groups (-9.00 D PRK or nearly full-thickness incisional wounds), whereas the opposite eyes served as the unwounded control group...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28485528/bioengineered-keratocyte-spheroids-fabricated-on-chitosan-coatings-enhance-tissue-repair-in-a-rabbit-corneal-stromal-defect-model
#6
Shih-Feng Chou, Chih-Hung Lee, Jui-Yang Lai
Cultivated cell spheroid transplantation is widely studied as a means of facilitating tissue regeneration. Chitosan biomaterial has been shown to promote keratocyte aggregation and multicellular spheroid formation. Herein, we provide further evidence on application of bioengineered keratocyte spheroids for corneal stromal tissue engineering. In an allogeneic rabbit model of stromal destruction caused by bacterial keratitis, the corneas were intrastromally injected with isolated keratocyte suspensions or aggregated spheroid grafts at same cell number...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28457313/late-onset-of-persistent-deep-stromal-haze-after-corneal%C3%A2-cross-linking%C3%A2-in-a-patient-with-keratoconus
#7
Rawan Omary, Raneen Shehadeh-Mashor
No abstract text is available yet for this article.
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28453408/salmonella-typhi-associated-endogenous-endophthalmitis-a-case-report-and-a-review-of-literature
#8
Suchit D Dadia, Rohit Ramesh Modi, Shruti Shirwadkar, Nayana A Potdar, Chhaya A Shinde, Akshay Gopinathan Nair
AIM: To report a rare case of Salmonella typhi associated endogenous endophthalmitis in an immunocompetent male and to review the available literature. METHODS: Retrospective chart review. RESULTS: A 28-year-old immunocompetent male presented with a 3-day-old history of pain, redness and diminished vision in his left eye. Conjunctival chemosis, corneal haze, and hypopyon were noted and yellowish exudates filled the vitreous cavity. A detailed elicitation of history revealed that patient had been treated for enteric fever that presented with diarrhea and fever, two weeks prior to current presentation...
April 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28450791/a-case-report-of-central-toxic-keratopathy-in-a-patient-post-transprk-followed-by-corneal-collagen-cross-linking
#9
Nicholas Davey, Ioannis M Aslanides, Vasilis Selimis
PURPOSE: The purpose of this article is to report a case of central toxic keratopathy in a patient post transepithelial photorefractive keratectomy (TransPRK), followed immediately by corneal collagen cross-linking. METHODS: This article describes the case of a 26-year-old male after bilateral aberration-free, TransPRK laser (Schwind Amaris 750S). The procedure was performed for compound myopic astigmatism in November 2015, followed immediately by accelerated corneal collagen cross-linking for early keratoconus...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28420926/femto-lasik-the-recent-innovation-in-laser-assisted-refractive-surgery
#10
Zubair Shahid Bashir, Muhammad Hassaan Ali, Ayesha Anwar, Muhammad Hammad Ayub, Nadeem Hafeez Butt
Femtosecond laser has been introduced in refractive surgery to create a thin-hinged corneal flap without using any blade. The current review was planned to analyse and compare femtosecond-assisted laser in-situ keratomileusis (LASIK), the latest refractive procedure, with conventional techniques in refractive surgery. The analysis showed that femtosecond-assisted LASIK yielded more predictable corneal flaps, lesser ocular aberrations, better uncorrected visual acuity, lesser variations in intraocular pressure (IOP) and fewer chances of developing dry eyes...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28410723/risk-factors-predicting-steroid-induced-ocular-hypertension-after-photorefractive-keratectomy
#11
Yumna Busool, Michael Mimouni, Igor Vainer, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To assess the risk factors contributing to steroid-induced ocular hypertension after photorefractive keratectomy (PRK). SETTING: Care Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Patients having PRK between January 2000 and December 2015 were followed for at least 3 months. Intraocular pressure (IOP) was measured using the Goldmann applanation tonometer after 1 week and after 1, 3, and 6 months...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410355/descemetorhexis-without-graft-placement-for-the-treatment-of-fuchs-endothelial-dystrophy-preliminary-results-and-review-of-the-literature
#12
Alfonso Iovieno, Alberto Neri, Anna Maria Soldani, Chantal Adani, Luigi Fontana
PURPOSE: To report our preliminary experience with a central descemetorhexis without graft placement in Fuchs endothelial corneal dystrophy (FECD) and to review the existing literature on the topic. METHODS: A 4-mm central descemetorhexis was performed in 5 patients (4 women, 1 man; mean age: 69.8 ± 8.6 yrs; range: 57-78 yrs) with FECD. All patients had central confluent guttae, undetectable central endothelial cell count, healthy peripheral corneal endothelium, no clinically evident bullous keratopathy, and no ocular comorbidities...
June 2017: Cornea
https://www.readbyqxmd.com/read/28393038/single-step-transepithelial-photorefractive-keratectomy-in-high-myopia-qualitative-and-quantitative-visual-functions
#13
Soheil Adib-Moghaddam, Saeed Soleyman-Jahi, Fatemeh Adili-Aghdam, Samuel Arba Mosquera, Niloofar Hoorshad, Salar Tofighi
AIM: To investigate quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) in high myopia. METHODS: In a prospective interventional case-series, 30 eyes with high myopia (-6.00 to -8.75 D) with (up to -3.00 D) or without astigmatism were enrolled from Bina Eye Hospital, Tehran, Iran. One-step TransPRK was performed with aberration-free aspherical optimized profile and SCHWIND AMARIS 500 laser. One-year follow-up results for refraction, visual acuities, vector analysis, ocular wave-front (OWF) and corneal wave-front (CWF) higher order aberrations (HOA), contrast sensitivity (CS), and post-operative haze were assessed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28356099/corneal-densitometry-changes-in-a-patient-with-interface-fluid-syndrome-after-small-incision-lenticule-extraction
#14
Ke Zheng, Tian Han, Meiyan Li, Yinan Han, Ye Xu, Rupal Shah, Xingtao Zhou
BACKGROUND: To report a case of interface fluid syndrome (IFS) following small incision lenticule extraction (SMILE) evaluated with corneal densitometry and optical coherence tomography (OCT). CASE PRESENTATION: An 18-year-old man reported sudden vision loss 24 days after SMILE procedure. Intraocular pressure (IOP) was 36.3 mmHg (OD) and 36.7 mmHg (OS) by noncontact tonometry. Moderate corneal edema, interface fluid pocket and haze were observed by OCT and confirmed by corneal densitometry values...
March 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28339457/targeted-aav5-smad7-gene-therapy-inhibits-corneal-scarring-in-vivo
#15
Suneel Gupta, Jason T Rodier, Ajay Sharma, Elizabeth A Giuliano, Prashant R Sinha, Nathan P Hesemann, Arkasubhra Ghosh, Rajiv R Mohan
Corneal scarring is due to aberrant activity of the transforming growth factor β (TGFβ) signaling pathway following traumatic, mechanical, infectious, or surgical injury. Altered TGFβ signaling cascade leads to downstream Smad (Suppressor of mothers against decapentaplegic) protein-mediated signaling events that regulate expression of extracellular matrix and myogenic proteins. These events lead to transdifferentiation of keratocytes into myofibroblasts through fibroblasts and often results in permanent corneal scarring...
2017: PloS One
https://www.readbyqxmd.com/read/28299001/comparison-of-loteprednol-with-fluorometholone-after-myopic-photorefractive-keratectomy
#16
Farid Karimian, Amir Faramarzi, Sahba Fekri, Hossein Mohammad-Rabie, Danial Najdi, Azadeh Doozandeh, Siamak Delfaza-Baher, Mehdi Yaseri
PURPOSE: To compare the efficacy and side effects of loteprednol versus fluorometholone after myopic photorefractive keratectomy (PRK). METHODS: One hundred and twenty four eyes of 62 patients who underwent PRK were enrolled in this study. One eye of each subject was randomized to receive loteprednol 0.5% and the fellow eye was given fluorometholone 0.1%. Patients were followed up for three months. RESULTS: There was no significant difference in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, corneal haze, intraocular pressure (IOP), and ocular discomfort and redness between groups at the final visit...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#17
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275314/ebm-regeneration-and-changes-in-ebm-component-mrna-expression-in-stromal-cells-after-corneal-injury
#18
Abirami Santhanam, Gustavo K Marino, Andre A M Torricelli, Steven E Wilson
PURPOSE: To investigate the production of the epithelial basement membrane (EBM) component mRNAs at time points before lamina lucida and lamina densa regeneration in anterior stromal cells after corneal injury that would heal with and without fibrosis. METHODS: Rabbit corneas were removed from 2 to 19 days after -4.5D or -9.0D photorefractive keratectomy (PRK) with the VISX S4 IR laser. Corneas were evaluated with transmission electron microscopy (TEM) for full regeneration of the lamina lucida and the lamina densa...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28251081/effects-of-contact-lens-wearing-on-keratoconus-a-confocal-microscopy-observation
#19
Somnath Ghosh, Haliza A Mutalib, Sharanjeet-Kaur, Rituparna Ghoshal, Shamala Retnasabapathy
AIM: To evaluate the corneal cell morphology of new keratoconus patients wearing two different types of rigid gas-permeable (RGP) contact lenses for 1y. METHODS: Thirty nine eyes of 39 new keratoconus patients were selected and randomly fitted with two types of RGP contact lenses. Group 1 had 21 eyes with regular rigid gas-permeable (RRGP) contact lens and rest 18 eyes were in group 2 with specially designed rigid gas-permeable (SRGP) contact lens. Corneal cell morphology was evaluated using a slit scanning confocal microscope at no-lens wear and after 1y of contact lens wearing...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28243019/clinical-outcomes-of-an-optimized-prolate-ablation-procedure-for-correcting-residual-refractive-errors-following-laser-surgery
#20
Byunghoon Chung, Hun Lee, Bong Joon Choi, Kyung Ryul Seo, Eung Kwon Kim, Dae Yune Kim, Tae-Im Kim
PURPOSE: The purpose of this study was to investigate the clinical efficacy of an optimized prolate ablation procedure for correcting residual refractive errors following laser surgery. METHODS: We analyzed 24 eyes of 15 patients who underwent an optimized prolate ablation procedure for the correction of residual refractive errors following laser in situ keratomileusis, laser-assisted subepithelial keratectomy, or photorefractive keratectomy surgeries. Preoperative ophthalmic examinations were performed, and uncorrected distance visual acuity, corrected distance visual acuity, manifest refraction values (sphere, cylinder, and spherical equivalent), point spread function, modulation transfer function, corneal asphericity (Q value), ocular aberrations, and corneal haze measurements were obtained postoperatively at 1, 3, and 6 months...
February 2017: Korean Journal of Ophthalmology: KJO
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