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https://www.readbyqxmd.com/read/29750010/comparative-analysis-of-safety-and-efficacy-of-photorefractive-keratectomy-versus-photorefractive-keratectomy-combined-with-crosslinking
#1
Gitansha Shreyas Sachdev, Shreyas Ramamurthy, Ramamurthy Dandapani
Purpose: To assess the safety, efficacy, and refractive predictability of half-fluence accelerated corneal collagen crosslinking (CXL) applied concurrently with photorefractive keratectomy (PRK), and compare the results to standard PRK. Setting: Refractive Services, The Eye Foundation, Coimbatore, India. Design: Interventional comparative case series. Methods: Patients seeking refractive correction for myopia or myopic astigmatism were included in the study...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29746325/corneal-cross-linking-in-pediatric-patients-evaluating-treated-and-untreated-eyes-5-year-follow-up-results
#2
Lior Or, Assaf Rozenberg, Adi Abulafia, Isaac Avni, David Zadok
PURPOSE: To evaluate the long-term results of corneal collagen cross-linking (CXL) for treatment of pediatric keratoconus and the long-term outcomes of the fellow untreated keratoconic eye in patients younger than 18 years old. METHODS: A retrospective case analysis was performed on 88 eyes of 44 patients aged 18 years or younger, with keratoconus, who underwent CXL in at least 1 eye. Follow-up measurements, for the treated and untreated eye pair, taken up to 5 years after treatment, were compared with baseline values...
May 3, 2018: Cornea
https://www.readbyqxmd.com/read/29738595/corneal-inlays-for-presbyopia-explanted-due-to-corneal-haze
#3
Hon Shing Ong, Anita S Chan, Christine W Yau, Jodhbir S Mehta
PURPOSE: To present 3 patients who required explantation of KAMRA inlays (AcuFocus, Inc., Irvine, CA) due to visual symptoms caused by postoperative corneal haze. METHODS: Case series. RESULTS: All patients had good near and distance vision immediately following implantation. They developed visual symptoms 3 to 6 years later. All patients reported a decline in distance vision. Two patients had hyperopic shift with flattening of the central cornea...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29685130/cataract-surgery-in-patients-with-corneal-opacities
#4
Yi-Ju Ho, Chi-Chin Sun, Hung-Chi Chen
BACKGROUND: Investigating the efficacy and safety of phacoemulsification with intraocular lens (IOL) implantation in corneal opacities. METHODS: This retrospective study was conducted in a tertiary medical center. Twenty-three eyes of 19 patients with cataracts and corneal opacities obscuring the pupillary center having received phacoemulsification with IOL insertion without any ancillary techniques were enrolled. The primary study outcome measures were uncorrected and best corrected visual acuity (BCVA), and complications...
April 23, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29681835/diagnostic-and-management-tool-for-monitoring-patients-implanted-with-a-shape-changing-corneal-inlay
#5
Ralph Chu, Briana R Lee
We report two cases that underwent corneal inlay implantation under a femtosecond flap. The first case had no complications during the postoperative period. Pentacam maps remained stable over time: corneal densitometry (CD) values had less than 2 units of change across visits up to 3 years. Axial/sagittal topography maps showed a stable Kmax (∼47 D), i.e., less than 1 D change between visits. The second case developed haze at 8 months postoperatively. CD increased by more than 4 units from 3 to 8 M and Kmax increased by 2...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29675379/photorefractive-keratectomy-after-cataract-surgery-in-uncommon-cases-long-term-results
#6
Anna Maria Roszkowska, Mario Urso, Giuseppe Alberto Signorino, Leopoldo Spadea, Pasquale Aragona
AIM: To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens (IOL) implantation in uncommon cases. METHODS: Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29610222/two-year-follow-up-of-corneal-cross-linking-and-refractive-surface-ablation-in-patients-with-asymmetric-corneal-topography
#7
João Baptista N S Malta, H Kaz Soong, Bernardo Kaplan Moscovici, Mauro Campos
AIMS: To evaluate the safety and efficacy of corneal cross-linking (CXL) followed by photorefractive keratectomy (PRK) for refractive correction in patients with bilateral asymmetric topography. METHODS: Forty-four patients (88 eyes) were enrolled in this prospective randomised clinical trial. CXL with subsequent PRK after 6 months was performed in one eye (study group), and PRK alone was performed in contralateral eyes (control group). Patients were followed for 24 months after PRK...
April 2, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29596534/the-characteristics-of-premature-infants-with-transient-corneal-haze
#8
Yu-Hung Lai, Hsiu-Lin Chen, San-Nan Yang, Shun-Jen Chang, Lea-Yea Chuang, Wen-Chuan Wu
BACKGROUND: The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear. OBJECTIVES: To study associated factors of transient corneal haze in premature infants. METHODS: We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses...
2018: PloS One
https://www.readbyqxmd.com/read/29538101/automated-detection-and-classification-of-corneal-haze-using-optical-coherence-tomography-in-patients-with-keratoconus-after-cross-linking
#9
Ahmad R Dhaini, Maamoun Abdul Fattah, Sara Maria El-Oud, Shady T Awwad
PURPOSE: To evaluate a proposed technology for offering objective grading and mapping of corneal haze as detected by corneal spectral domain optical coherence tomography after corneal cross-linking. METHODS: This was a retrospective study to evaluate corneal optical coherence tomography images performed on 44 eyes of 44 patients who underwent corneal cross-linking between January 2014 and May 2015, at the American University of Beirut Medical Center. RESULTS: Overall average brightness of the cornea was markedly increased from 43...
March 13, 2018: Cornea
https://www.readbyqxmd.com/read/29490341/novel-combination-bmp7-and-hgf-gene-therapy-instigates-selective-myofibroblast-apoptosis-and-reduces-corneal-haze-in-vivo
#10
Suneel Gupta, Michael K Fink, Arkasubhra Ghosh, Ratnakar Tripathi, Prashant R Sinha, Ajay Sharma, Nathan P Hesemann, Shyam S Chaurasia, Elizabeth A Giuliano, Rajiv R Mohan
Purpose: We tested the potential of bone morphogenic protein 7 (BMP7) and hepatocyte growth factor (HGF) combination gene therapy to treat preformed corneal fibrosis using established rabbit in vivo and human in vitro models. Methods: Eighteen New Zealand White rabbits were used. Corneal fibrosis was produced by alkali injury. Twenty-four hours after scar formation, cornea received topically either balanced salt solution (BSS; n = 6), polyethylenimine-conjugated gold nanoparticle (PEI2-GNP)-naked plasmid (n = 6) or PEI2-GNP plasmids expressing BMP7 and HGF genes (n = 6)...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29481786/fibrocyte-migration-differentiation-and-apoptosis-during-the-corneal-wound-healing-response-to-injury
#11
Luciana Lassance, Gustavo K Marino, Carla S Medeiros, Shanmugapriya Thangavadivel, Steven E Wilson
The aim of this study was to determine whether bone marrow-derived fibrocytes migrate into the cornea after stromal scar-producing injury and differentiate into alpha-smooth muscle actin (αSMA) + myofibroblasts. Chimeric mice expressing green fluorescent protein (GFP) bone marrow cells had fibrosis (haze)-generating irregular phototherapeutic keratectomy (PTK). Multiplex immunohistochemistry (IHC) for GFP and fibrocyte markers (CD34, CD45, and vimentin) was used to detect fibrocyte infiltration into the corneal stroma and the development of GFP+ αSMA+ myofibroblasts...
May 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29474298/descemet-membrane-endothelial-keratoplasty-for-failed-deep-anterior-lamellar-keratoplasty-a-case-series
#12
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Zale Mednick, Mohammad Kreimei, Clara C Chan, David S Rootman
PURPOSE: To suggest a new surgical approach for posterior opacities or persistent Descemet membrane (DM) detachment in failed deep anterior lamellar keratoplasty (DALK) and to report the outcome of Descemet membrane endothelial keratoplasty (DMEK) in a series of patients with DALK failure. METHODS: In this retrospective case series of patients who underwent DMEK for failed DALK at Toronto Western Hospital, 4 patients with failed DALK who underwent DMEK surgery were included...
June 2018: Cornea
https://www.readbyqxmd.com/read/29468296/-corneal-densitometry-value-for-keratoconus-diagnostics
#13
REVIEW
M Alnawaiseh, N Eter
BACKGROUND: Corneal densitometry, based on the Scheimpflug principle, is a useful noninvasive tool for quantitative evaluation of the optical quality of the cornea. It enables us to evaluate corneal transparency in the different corneal layers and different annuli. In this article, we discuss the basis of application of corneal densitometry measurements and summarize findings in patients with keratoconus. METHODS: This article is based on a selective literature review and analysis of own data...
February 21, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29443809/association-between-visual-acuity-and-the-corneal-area-occupied-by-granular-lesions-linear-lesions-or-diffuse-haze-in-patients-with-granular-corneal-dystrophy-type-2
#14
Hong Seok Kim, Tyler Hyungtaek Rim, Tae-Im Kim, Eung Kweon Kim
PURPOSE: In granular corneal dystrophy type 2 (GCD2), corneal deposits containing fragments of transforming growth factor-β-induced protein appear in sequence as granular lesions (GLs), linear lesions (LLs), and diffuse haze (DH). We aimed to investigate the association between visual acuity and age-related changes in lesion types in patients with GCD2. METHODS: We retrospectively evaluated the medical records and slit-lamp photographs of 533 patients (1066 eyes) with genetically confirmed GCD2 (heterozygous)...
May 2018: Cornea
https://www.readbyqxmd.com/read/29421383/latrunculin-b-and-substratum-stiffness-regulate-corneal-fibroblast-to-myofibroblast-transformation
#15
Sara M Thomasy, Vijay Krishna Raghunathan, Hidetaka Miyagi, Alexander T Evashenk, Jasmyne C Sermeno, Geneva K Tripp, Joshua T Morgan, Christopher J Murphy
The transformation of keratocytes and fibroblasts to myofibroblasts is important to corneal wound healing as well as formation of stromal haze. The purpose of this study was to determine the effect of latrunculin B, an actin cytoskeleton disruptor in conjunction with a fundamental biophysical cue, substrate stiffness, on myofibroblast transformation in vitro and in vivo. Rabbit corneal fibroblasts were cultured on substrates of differing compliance (1.5, 22, and 71 kPa) and tissue culture plastic (TCP; > 1 GPa) in media containing 0 or 10 ng/ml TGFβ1 for 72 h...
May 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29390522/delayed-onset-mycobacterium-intracellulare-keratitis-after-laser-in-situ-keratomileusis-a-case-report-and-literature-review
#16
REVIEW
JaeSang Ko, Se Kyung Kim, Dong Eun Yong, Tae-Im Kim, Eung Kweon Kim
RATIONALE: Infectious keratitis is a relatively uncommon but potentially sight-threatening complication of laser in situ keratomileusis (LASIK). Mycobacterial keratitis is usually regarded as late onset keratitis among post-LASIK keratitis. There has been no documented case of Mycobacterium intracellulare post-LASIK keratitis of a long-latent period. PATIENT CONCERNS: A 36-year-old man was referred to our out-patient clinic, for persistent corneal epithelial defect with intrastromal infiltration...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29366613/keratoendotheliitis-fugax-hereditaria-a-novel-cryopyrin-associated-periodic-syndrome-caused-by-a-mutation-in-the-nucleotide-binding-domain-leucine-rich-repeat-family-pyrin-domain-containing-3-nlrp3-gene
#17
Joni A Turunen, Juho Wedenoja, Pauliina Repo, Reetta-Stiina Järvinen, Johannes E Jäntti, Sanna Mörtenhumer, Antti S Riikonen, Anna-Elina Lehesjoki, Anna Majander, Tero T Kivelä
PURPOSE: To describe the phenotype and the genetic defect in keratoendotheliitis fugax hereditaria, an autosomal dominant keratitis that periodically affects the corneal endothelium and stroma, leading in some patients to opacities and decreased visual acuity. DESIGN: Cross-sectional, hospital-based study. METHODS: Patient Population: Thirty affected and 7 unaffected subjects from 7 families, and 4 sporadic patients from Finland. OBSERVATION PROCEDURES: Ophthalmic examination and photography, corneal topography, specular microscopy, and optical coherence tomography in 34 patients, whole exome sequencing in 10 patients, and Sanger sequencing in 34 patients...
April 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29349523/prognostic-factors-of-pediatric-glaucoma-a-retrospective-study
#18
Marilita M Moschos, Eirini Nitoda, Isabelle Fenzel, Xuefei Song, Achim Langenbucher, Barbara Kaesmann, Berthold Seitz, Zisis Gatzioufas
PURPOSE: To correlate the features of certain types of infantile glaucoma with the progression and the prognosis of the disease, highlighting probable risk factors. METHODS: Seventy-six patients with pediatric glaucoma were recruited in this retrospective study. All patients underwent ophthalmological examination in the Department of Ophthalmology of the Saarland University Medical Center from January 2001 to December 2012. Our pediatric patients were classified into four different categories of glaucoma: (1) primary congenital glaucoma (presenting buphthalmus), (2) aniridia-related glaucoma, (3) Peters/Rieger's anomaly-related glaucoma and (4) congenital cataract-related glaucoma...
January 18, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29339065/accommodative-esotropia-treatment-plan-utilizing-simultaneous-strabismus-surgery-and-photorefractive-keratectomy
#19
H Sprague Eustis, Pulin Shah
PURPOSE: Accommodative esotropia is a common cause of acquired esotropia. Pathogenesis varies among patients but usually includes excessive hyperopia and a high accommodative convergence/accommodation ratio or tight medial recti. The present study reviews an individualized treatment plan combining photorefractive keratectomy (PRK) and strabismus surgery to correct these problems. DESIGN: This study is a retrospective, interventional case series. METHODS: Records for 15 patients who were treated for accommodative esotropia were reviewed...
March 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296550/comparison-of-transepithelial-corneal-crosslinking-with-epithelium-off-crosslinking-epithelium-off-cxl-in-adult-pakistani-population-with-progressive-keratoconus
#20
Bushra Akbar, Rana Intisar-Ul-Haq, Mazhar Ishaq, Ayesha Fawad, Sabahat Arzoo, Kashif Siddique
PURPOSE: The purpose of this study is to compare the safety and efficacy of transepithelial corneal crosslinking (CXL) with epithelium-off crosslinking (epithelium-off CXL) in the treatment of progressive keratoconus in adult Pakistani population. MATERIALS AND METHODS: Sixty-four eyes of 64 consecutive patients of progressive keratoconus were included in this quasi-experimental study. Thirty-two eyes received transepithelial CXL with Peschke TE (0.25% riboflavin (Vitamin B2), 1...
October 2017: Taiwan Journal of Ophthalmology
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