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https://www.readbyqxmd.com/read/29141390/-the-clinical-analysis-of-corneal-interface-fluid-syndrome-after-laser-lamellar-corneal-refractive-surgery
#1
K J Lin, J Chen, W Lin, X D Lin, Y M Zhou, L D Zheng, Y Tong
Objective: To analysis, the clinical characteristics, refractive changes, and clinical treatment of interface fluid syndrome after laser lamellar corneal refractive surgery. Methods: During Dec. 2010 to Apr. 2016. In total 6 cases(9 eyes), 3 cases were bilateral, 3 cases were unilateral. Five patients were male and 1 was female. The age of the patients ranged from 20 to 29 years was (24.83±4.02) years. Six cases(9 eyes)of IFS were diagnosed at our hospital. The history and complete ophthalmic examination that include Slit-lamp examination, Slit-lamp photography, refraction, corneal thickness measurement, corneal endothelial cell counting, IOP, anterior segment OCT(AS-OCT), exams were recorded...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29111069/chitosan-and-thiolated-chitosan-novel-therapeutic-approach-for-preventing-corneal-haze-after-chemical-injuries
#2
Forouhe Zahir-Jouzdani, Mirgholamreza Mahbod, Masoud Soleimani, Faezeh Vakhshiteh, Ehsan Arefian, Saeed Shahosseini, Rasoul Dinarvand, Fatemeh Atyabi
Corneal haze, commonly caused by deep physical and chemical injuries, can greatly impair vision. Growth factors facilitate fibroblast proliferation and differentiation, which leads to haze intensity. In this study, the potential effect of chitosan (CS) and thiolated-chitosan (TCS) nanoparticles and solutions on inhibition of fibroblast proliferation, fibroblast to myofibroblast differentiation, neovascularization, extracellular matrix (ECM) deposition, and pro-fibrotic cytokine expression was examined. Transforming growth factor beta-1 (TGFβ1) was induced by interleukin-6 (IL6) in human corneal fibroblasts and expression levels of TGFβ1, Platelet-derived growth factor (PDGF), α-smooth muscle actins (α-SMA), collagen type I (Col I), fibronectin (Fn) and vascular endothelial growth factor (VEGF) were quantified using qRT-PCR...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29103962/corneal-stroma-enhancement-with-decellularized-stromal-laminas-with-or-without-stem-cell-recellularization-for-advanced-keratoconus
#3
Jorge L Alió Del Barrio, Mona El Zarif, Albert Azaar, Nehman Makdissy, Charbel Khalil, Walid Harb, Ibrahim El Achkar, Ziad Abdul Jawad, María P de Miguel, Jorge L Alió
PURPOSE: Phase-1 study to preliminarily evaluate the safety and efficacy of decellularized human corneal stromal lamina transplantation with or without autologous adipose derived adult stem cells (ADASC) recellularization within the corneal stroma of patients with advanced keratoconus. DESIGN: Phase one clinical trial METHODS: Femtosecond-assisted 120μm-thickness and 9mm-diameter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate solution...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29082123/ocular-surface-chemical-injury-treated-by-regenerating-agent-rgta-cacicol20
#4
Melih Ustaoglu, Nilgun Solmaz, Feyza Onder
Objective: To present the successful outcome of regenerating agent (RGTA) treatment in a patient with severe ocular surface chemical injury. Methods: Case report Results: A 14-year-old female patient was admitted to our clinic following chemical burn in the left eye. Her best corrected visual acuity (BCVA) was 20/40; and she had total corneal and 75% conjunctival epithelial loss, corneal haze, and limbal ischemia for nine clock hours in the left eye. The patient had already received standard therapy consisting of patching, preservative-free artificial tears, topical netilmicin, topical dexamethasone, oral doxycycline, and vitamin C for two weeks...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/29067107/conventional-vs-pulsed-light-accelerated-corneal-collagen-cross-linking-for-the-treatment-of-progressive-keratoconus-12-month-results-from-a-prospective-study
#5
Liang-Zhu Jiang, Wei Jiang, Shi-Yan Qiu
The aim of the present study was to compare the clinical outcomes of conventional corneal collagen cross-linking (CXL) and pulsed-light accelerated CXL (pl-ACXL) in the eyes of patients with progressive keratoconus. A total of 72 eyes with progressive keratoconus in 58 patients were equally divided into the CXL and pl-ACXL treatment groups. The CXL treatment was performed using the UVX 1000 system with 0.1% riboflavin solution in 20% dextran presoak for 30 min, and 3 mW/cm(2) ultraviolet A (UVA) light for 30 min...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29019068/early-epithelial-complications-of-accelerated-trans-epithelial-corneal-crosslinking-in-treatment-of-keratoconus-a-case-series
#6
Sharon S W Chow, Tommy C Y Chan, Ian Y H Wong, Michelle C Y Fan, Jimmy S M Lai, Alex L K Ng
BACKGROUND: To report a case series of early postoperative complications following combined accelerated corneal crosslinking (CXL) and trans-epithelial technique in keratoconus. CASE PRESENTATIONS: Eleven eyes underwent accelerated trans-epithelial CXL (18 mW/cm(2) for 5 min). Seven eyes (64%) developed complications in the first week postoperatively. Five eyes had large epithelial defects, and two eyes were complicated with diffuse punctate epithelial erosions...
October 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29018762/visual-performance-after-excimer-laser-photorefractive-keratectomy-for-high-myopia
#7
Yu-Ling Liu, Chien-Chi Tseng, Chang-Ping Lin
PURPOSE: To evaluate the efficacy, safety, predictability, and visual performance of excimer laser photorefractive keratectomy (PRK) for myopia greater than -8 diopters (D). METHODS: Fifty-four patients (104 eyes) with myopia from -8D to -13D and cylinder up to -4D received surface ablation technique with the Allegretto wave version 1009-1 excimer laser to correct their refractive error. The patients were examined on days 1, 3, 7, and 14 and 1, 3, 6, and 12 months postoperatively...
April 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/28985815/young-donor-graft-assisted-endothelial-keratoplasty-pdek-dmek-with-epithelial-debridement-for-chronic-pseudophakic-bullous-keratopathy
#8
Amar Agarwal, Priya Narang, Dhivya A Kumar, Ashvin Agarwal
OBJECTIVE: The aim of this study was to describe the applicability and report visual outcomes for the treatment of subepithelial fibrosis and anterior stromal scarring in cases of chronic pseudophakic bullous keratopathy (PBK) with epithelial debridement and endothelial keratoplasty (EK) (pre-Descemet endothelial keratoplasty [PDEK]; Descemet membrane endothelial keratoplasty [(DMEK]) using young donor tissue. DESIGN: Prospective, single-centre, interventional study...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28945648/clinical-study-of-mitomycin-c-in-reducing-haze-formation-after-ultraviolet-a-riboflavin-crosslinking-for-keratoconus
#9
Linlin Xu, Xiangchen Tao, Zhiwei Li, Yanyun Xu, Wei Zhu, Huijuan Xu, Wei Pu, Yi Xie, Guoying Mu
OBJECTIVES: To evaluate the safety and efficacy of mitomycin C (MMC) in haze formation after ultraviolet A/riboflavin corneal crosslinking (CXL) for progressive keratoconus. METHODS: A total of 60 keratoconic eyes of 48 patients were enrolled in this prospective comparative study after obtaining informed consent. In the CXL group, standard corneal CXL was performed, whereas in the CXL+MMC group, 0.02% MMC was used for 30 s soon after CXL. Comprehensive ophthalmologic examinations were performed on all patients before surgery and at 1, 3, 6, and 12 months after surgery...
September 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28894403/corneal-cell-morphology-in-keratoconus-a-confocal-microscopic-observation
#10
Somnath Ghosh, Haliza Abdul Mutalib, Sharanjeet Kaur, Rituparna Ghoshal, Shamala Retnasabapathy
PURPOSE: To evaluate corneal cell morphology in patients with keratoconus using an in vivo slit scanning confocal microscope. METHODS: A cross-sectional study was conducted to evaluate the corneal cell morphology of 47 keratoconus patients and 32 healthy eyes without any ocular disease. New keratoconus patients with different disease severities and without any other ocular co-morbidity were recruited from the ophthalmology department of a public hospital in Malaysia from June 2013 to May 2014...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28872519/changes-in-corneal-density-after-accelerated-corneal-collagen-cross-linking-with-different-irradiation-intensities-and-energy-exposures-1-year-follow-up
#11
Semra Akkaya Turhan, Ebru Toker
PURPOSE: To determine and compare the changes in corneal density after 2 different protocols of accelerated corneal collagen cross-linking (A-CXL) in patients with progressive keratoconus. METHODS: Two groups of eyes received A-CXL treatment; 20 eyes received A-CXL using continuous UVA light exposure at 9 mW/cm for 10 minutes with a total energy dose of 5.4 J/cm, and 24 eyes received A-CXL using continuous UVA light exposure at 30 mW/cm for 4 minutes with a total energy dose of 7...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28827430/topical-ayurvedic-ointment-induced-chemical-injury-presenting-as-bilateral-acute-keratitis
#12
Pranita Sahay, Gunjan Saluja, Prafulla Kumar Maharana, Jeewan S Titiyal
A 40-years-old female patient was referred to the cornea clinic as a probable case of bilateral keratitis. The patient had a history of headache followed by acute onset of redness, pain and discharge from both eyes for 15 days. The patient was diagnosed as bilateral keratitis by the first contact physician and was started on topical antibiotics, cycloplegics and lubricating eye-drops. At presentation, both eyes had visual acuity of perception of light, conjunctival congestion, limbal blanching, diffuse corneal oedema and epithelial defect...
August 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28721004/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-reduction-of-low-myopia
#13
Wee Kiak Lim, Zhi Da Soh, Harold Kah Yen Choi, Julian Thiam Siew Theng
PURPOSE: To report the 9-12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. METHOD: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28708898/retreatment-strategies-following-small-incision-lenticule-extraction-smile-in-vivo-tissue-responses
#14
Andri K Riau, Yu-Chi Liu, Chris H L Lim, Nyein C Lwin, Ericia P Teo, Gary H Yam, Donald T Tan, Jodhbir S Mehta
With any refractive correction, including Small Incision Lenticule Extraction (SMILE), there may be a residual refractive error that requires a retreatment. Here, we investigated the tissue responses following various retreatment procedures in a rabbit model of SMILE. All rabbits underwent a -6.00D correction with SMILE. Two weeks later, they underwent -1.00D enhancement by: (i) VisuMax Circle, followed by excimer ablation (S+C); (ii) secondary SMILE anterior to the primary procedure (S+SE); or (iii) surface ablation (S+P), and were examined for 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/28659808/expression-of-concern-topical-ophthalmic-formulation-of-trichostatin-a-and-surr9-c84a-for-quick-recovery-post-alkali-burn-of-corneal-haze
#15
(no author information available yet)
No abstract text is available yet for this article.
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28655538/u-s-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-treatment-of-corneal-ectasia-after-refractive-surgery
#16
RANDOMIZED CONTROLLED TRIAL
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of corneal ectasia after laser refractive surgery. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: One hundred seventy-nine subjects with corneal ectasia after previous refractive surgery. METHODS: The treatment group underwent standard CXL, and the sham control group received riboflavin alone without removal of the epithelium...
October 2017: Ophthalmology
https://www.readbyqxmd.com/read/28652697/efficacy-and-safety-of-a-3-month-loteprednol-etabonate-0-5-gel-taper-for-routine-prophylaxis-after-photorefractive-keratectomy-compared-to-a-3-month-prednisolone-acetate-1-and-fluorometholone-0-1-taper
#17
Mark D Mifflin, Brent S Betts, P Adam Frederick, Jason M Feuerman, Carlton R Fenzl, Majid Moshirfar, Brian Zaugg
PURPOSE: To compare the outcome of photorefractive keratectomy (PRK) and complications in patients treated with either loteprednol etabonate 0.5% gel or prednisolone acetate 1% suspension and fluorometholone (fml) 0.1% suspension. SETTING: John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA. DESIGN: Prospective, randomized, partially masked trial. METHODS: PRK was performed on 261 eyes of 132 participants...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28651810/comparison-of-5468-retreatments-after-laser-in-situ-keratomileusis-by-lifting-the-flap-or-performing-photorefractive-keratectomy-on-the-flap
#18
J Ortega-Usobiaga, F Llovet-Osuna, T Katz, M R Djodeyre, V Druchkiv, R Bilbao-Calabuig, J Baviera
PURPOSE: To assess visual outcomes of retreatment after laser in situ keratomileusis (LASIK) by lifting the flap or performing photorefractive keratectomy (PRK) on the flap, as well as to establish whether there was an increased risk of epithelial ingrowth (EIG) when LASIK and lifting of the flap are separated by a long time interval and to determine the incidence of corneal haze after PRK. METHODS: Retrospective study of 4077 patients (5468 eyes) who underwent LASIK and subsequent retreatment were reviewed in order to study their visual results and identify cases of EIG and corneal haze...
June 23, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28626819/comparison-of-bandage-contact-lens-removal-on-the-fourth-versus-seventh-postoperative-day-after-photorefractive-keratectomy-a-randomized-clinical-trial
#19
Mehrdad Mohammadpour, Delaram Shakoor, Hassan Hashemi, Mohamad Aghaie Meybodi, Fateme Rajabi, Pegah Hosseini
PURPOSE: To compare the outcomes of bandage contact lens (BCL) removal on the fourth versus seventh post-operative day following photorefractive keratectomy (PRK). METHODS: This study recruited eyes of patients who underwent PRK surgery. The patients were randomly assigned to 2 groups. In Group 1 BCL was removed on the 4th postoperative day, while in Group 2, BCL was removed on the 7th postoperative day. After BCL removal, patients were asked to express their pain score and eye discomfort...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28599847/development-of-wound-healing-models-to-study-tgf%C3%AE-3-s-effect-on-sma
#20
Sriniwas Sriram, Jennifer A Tran, Xiaoqing Guo, Audrey E K Hutcheon, Andrius Kazlauskas, James D Zieske
The goal of this study was to test the efficacy of transforming growth factor beta 3 (TGFβ3) in reducing α-smooth muscle actin (SMA) expression in two models-an ex vivo organ culture and an in vitro 3D cell construct-both of which closely mimic an in vivo environment. For the ex vivo organ culture system, a central 6.0 mm corneal keratectomy was performed on freshly excised rabbit globes The corneas were then excised, segregated into groups treated with 1.0 ng/ml TGFβ1 or β3 (T1 or T3, respectively), and cultured for 2 weeks...
August 2017: Experimental Eye Research
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