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Accelerated CXL

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https://www.readbyqxmd.com/read/28626821/mesopic-visual-quality-after-accelerated-corneal-cross-linking-a-12-month-follow-up-study
#1
Hassan Hashemi, Soheila Asgari
PURPOSE: To determine the 1-year changes of mesopic higher order aberrations (HOAs) and contrast sensitivity (CS) after accelerated corneal cross linking (CXL) in progressive keratoconus. METHODS: In this prospective case series, 70 eyes of 62 keratoconic patients underwent accelerated CXL (18 mW/cm(2), 5 min). HOAs and CS were measured using the OPD Scan III and CSV-1000 CS test charts under mesopic conditions before and 6 and 12 months after CXL. RESULTS: At 1 year, logarithmic mesopic CS in spatial frequencies of 3, 6, 12, and 18 cycles per degree (CPD) had increased by 0...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28594649/accelerated-versus-conventional-corneal-crosslinking-for-refractive-instability-an-update
#2
REVIEW
George D Kymionis, George A Kontadakis, Kattayoon K Hashemi
PURPOSE OF REVIEW: Corneal crosslinking (CXL) is a relatively new treatment modality offering refractive stability in patients with ectatic disorders. The procedure as initially described (Dresden protocol) is time consuming; accelerated protocols have been lately developed. The purpose of this review is to present the recent findings regarding the comparison of accelerated CXL with the conventional Dresden protocol. RECENT FINDINGS: A variety of accelerated protocols are described in the literature...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28532937/collagen-crosslinking-with-conventional-and-accelerated-ultraviolet-a-irradiation-using-riboflavin-with-hydroxypropyl-methylcellulose
#3
Anne Marie Hagem, Andreas Thorsrud, Gunhild Falleth Sandvik, Marianne Råen, Liv Drolsum
PURPOSE: To evaluate corneal collagen crosslinking (CXL) with conventional and accelerated ultraviolet-A (UVA) irradiation using riboflavin with methylcellulose. SETTING: Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. DESIGN: Prospective randomized case series. METHODS: Patients with keratoconus were randomized to have CXL using conventional 3 mW/cm(2) UVA irradiation for 30 minutes (CXL30) or accelerated 9 mW/cm(2) UVA irradiation for 10 minutes (CXL10)...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28513495/effect-of-post-crosslinking-haze-on-the-repeatability-of-scheimpflug-based-and-slit-scanning-imaging-devices
#4
Rohit Shetty, Aarti Agrawal, Rashmi Deshmukh, Luci Kaweri, Harsha L Rao, Harsha Nagaraja, Chaitra Jayadev
PURPOSE: The aim of this study was to analyze the effect of postcollagen crosslinking (CXL) haze on the measurement and repeatability of pachymetry and mean keratometry (Km) of four corneal topographers. MATERIALS AND METHODS: Sixty eyes of sixty patients with progressive keratoconus who had undergone accelerated CXL (ACXL) underwent imaging with a scanning slit imaging device (Orbscan II) and three Scheimpflug imaging devices (Pentacam HR, Sirius, and Galilei)...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503442/clinical-outcomes-at-one-year-following-keratoconus-treatment-with-accelerated-transepithelial-cross-linking
#5
Alberto Artola, David P Piñero, Pedro Ruiz-Fortes, Roberto Soto-Negro, Rafael J Pérez-Cambrodí
This study evaluated the clinical outcomes in keratoconus corneas following accelerated transepithelial corneal collagen cross-linking (CXL) (Avedro KXL(®) system, Waltham, MA, USA) over one year of follow-up. The mean depth of the demarcation line measured by optical coherence tomography (OCT) was 205.19 µm. One month after surgery, a non-statistically significant change was noted in sphere (P=0.18) and in spherical equivalent (P=0.17), whereas a significant improvement was observed in corrected distance visual acuity (P=0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28486315/comparison-of-2-different-methods-of-transepithelial-corneal-collagen-cross-linking-analysis-of-corneal-histology-and-hysteresis
#6
Young Min Park, Ho Yoon Kim, Jong Soo Lee
PURPOSE: To compare the effect of 2 different methods of transepithelial corneal collagen cross-linking (CXL) on corneal histology and hysteresis. METHODS: The right eyes of New Zealand white rabbits (n = 50) were treated using one of the 2 transepithelial CXL methods. The eyes were then divided into 2 groups: group 1, transepithelial CXL using continuous ultraviolet A (UVA); group 2, accelerated transepithelial CXL using pulsed UVA. RESULTS: Both groups showed a postoperative increase in central corneal thickness...
July 2017: Cornea
https://www.readbyqxmd.com/read/28486312/biomechanical-and-histopathologic-effects-of-pulsed-light-accelerated-epithelium-on-off-corneal-collagen-cross-linking
#7
Xiaoyu Zhang, Ling Sun, Yang Shen, Mi Tian, Jing Zhao, Yu Zhao, Meiyan Li, Xingtao Zhou
PURPOSE: This study aimed to compare the biomechanical and histopathologic effects of transepithelial and accelerated epithelium-off pulsed-light accelerated corneal collagen cross-linking (CXL). METHODS: A total of 24 New Zealand rabbits were analyzed after sham operation (control) or transepithelial or epithelium-off operation (45 mW/cm for both). The transepithelial group was treated with pulsed-light ultraviolet A for 5 minutes 20 seconds, and the epithelium-off group was treated for 90 seconds...
July 2017: Cornea
https://www.readbyqxmd.com/read/28358253/comparison-of-accelerated-corneal-collagen-cross-linking-types-for-treating-keratoconus
#8
Yusuf Yıldırım, Onur Olcucu, Zehra Karaagac Gunaydin, Alper Ağca, Engin Bilge Ozgurhan, Cengiz Alagoz, Cagri Mutaf, Ahmet Demirok
PURPOSE: To compare the results of different protocols for accelerated corneal collagen cross-linking (CXL) in patients with progressive keratoconus. MATERIALS AND METHOD: This prospective comparative study involved 40 patients treated with intended UV-A radiance of 5.4 J/cm(2) in 74 eyes (Group 1) and 42 patients treated with radiance of 7.2 J/cm(2) in 72 eyes (Group 2). Visual acuity, subjective manifest refraction and corneal topography were analyzed before and 12 months after surgery in both groups...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28337057/accelerated-corneal-collagen-cross-linking-in-pediatric-keratoconus-one-year-study
#9
Amani E Badawi
PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next, riboflavin/hydroxypropyl methylcellulose solution) was applied for 10 min. Accelerated CXL (10 mW/cm(2) for 9 min), was accomplished. Visual acuity, slit lamp examination, refraction, keratometry readings, pachymetry, anterior and posterior elevations, average progression indices, and Q values were recorded...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28299302/cornea-collagen-cross-linking-for-keratoconus-a-comparison-between-accelerated-and-conventional-methods
#10
Hasan Razmjoo, Alireza Peyman, Ali Rahimi, Hoda Jafari Modrek
BACKGROUND: Keratoconus is a progressive degenerative disorder of the cornea in which structural changes in the cornea cause it to become thin and conical in shape. Recently, collagen cross-linking (CXL) has been introduced as an effective intervention in management of progressive keratoconus. Accelerated CXL is a new protocol of this procedure which reduces corneal ultraviolet irradiation exposure time to 5 min. This study aimed to compare visual acuity, keratometry and topographic criteria of keratoconic eyes after conventional and accelerated CXL with a six-month follow-up...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28264134/biomechanical-weakening-of-different-re-treatment-options-after-small-incision-lenticule-extraction-smile
#11
Sabine Kling, Bogdan Spiru, Farhad Hafezi, Walter Sekundo
PURPOSE: To determine the corneal weakening induced by different re-treatment options after small incision lenticule extraction (SMILE) and investigate the potential of corneal cross-linking (CXL) to reestablish the original corneal stress resistance. METHODS: A total of 96 freshly enucleated porcine corneas were used. The initial refractive correction was defined to be -11.00 diopters (D) and the required enhancement to be -3.00 D. Three different re-treatment options were analyzed: -3D Re-SMILE, -3D photorefractive keratectomy (PRK) on top of the SMILE cap, and cap-to-flap conversion and -3D excimer ablation on the stromal bed (LASIK)...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28264130/a-new-matrix-therapy-agent-for-faster-corneal-healing-and-less-ocular-discomfort-following-epi-off-accelerated-corneal-cross-linking-in-progressive-keratoconus
#12
Koray Gumus, Marta Gomes Guerra, Sara Homem de Melo Marques, Sarper Karaküçük, Denis Barritault
PURPOSE: To investigate the hypothesis that a new matrix therapy agent (ReGeneraTing Agent, [RGTA]) would speed up the corneal reepithelialization, improve stromal healing, and reduce ocular symptoms after epi-off corneal cross-linking (CXL). METHODS: Sixty eyes of 60 patients with progressive keratoconus were enrolled in the study. Epi-off accelerated CXL was performed in all patients. Sixty eyes were randomized into two groups according to use of RGTA eye drops prior to contact lens fitting at the end...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28244932/photopic-mesopic-and-scotopic-visual-acuity-after-18-mw-cm2-accelerated-corneal-cross-linking
#13
Soheila Asgari, Hassan Hashemi, Mohammad Miraftab, Saied Shahhoseini, Ebrahim Jafarzadhpur, Shiva Mehravaran, Akbar Fotouhi
OBJECTIVES: One-year changes in uncorrected (UDVA) and corrected (CDVA) distance visual acuity under different lighting conditions after accelerated cross-linking (CXL) in patients with progressive keratoconus in comparison with nontreated cases. METHODS: In this nonrandomized clinical trial, the sample included 50 eyes in the CXL group and 40 eyes in the control group. Visual acuity was tested under photopic (100 lux), mesopic (20 lux), and scotopic (0.5 lux) lighting conditions at 6 months and 1 year...
February 27, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28230557/comparison-of-the-conventional-dresden-protocol-and-accelerated-protocol-with-higher-ultraviolet-intensity-in-corneal-collagen-cross-linking-for-keratoconus
#14
Moonjung Choi, Jiwon Kim, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To compare the accelerated corneal cross-linking (CXL) protocol and the conventional Dresden protocol in patients with keratoconus in terms of visual acuity, keratometric values, and topographic parameters. METHODS: Twenty-eight eyes of 25 patients with primary keratoconus were divided into 2 groups; 15 eyes in group 1 received CXL under the standard Dresden protocol (3 mW/cm for 30 min, dose 5.4 J/cm) and 13 eyes in group 2 were treated with the accelerated protocol (30 mW/cm for 3 min 40 s, dose 6...
May 2017: Cornea
https://www.readbyqxmd.com/read/28197339/refractive-topographic-and-aberrometric-results-at-2-year-follow-up-for-accelerated-corneal-cross-link-for-progressive-keratoconus
#15
Ercüment Bozkurt, Engin Bilge Ozgurhan, Betul Ilkay Sezgin Akcay, Tugba Kurt, Yusuf Yildirim, Zehra Karaagaç Günaydin, Ahmet Demirok
Purpose. To report the visual, refractive, and corneal topography and wavefront aberration results of accelerated corneal cross-linking (CXL) during a 24-month follow-up. Methods. Forty-seven eyes underwent riboflavin-ultraviolet A-induced accelerated CXL treatment (30 mW/cm(2) with a total dose of 7.2 joules/cm(2)). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical and cylindrical values, keratometry (K) measurements (Ksteep, Kflat, Kavg, and Kapex), central corneal thickness, and anterior corneal aberrometric analyses including total wavefront error (WFE), total high order aberration (HOA), astigmatism, trefoil, coma, quadrafoil, secondary astigmatism, and spherical aberration were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28192592/an-algorithm-to-predict-the-biomechanical-stiffening-effect-in-corneal-cross-linking
#16
Sabine Kling, Farhad Hafezi
PURPOSE: To develop an algorithm to predict the stiffening effect of CXL and to verify the accuracy with results obtained from experimental measurements. METHODS: The algorithm considers different variables: the reaction kinetics of riboflavin diffusion and riboflavin photodegradation to determine the effective riboflavin concentration in different stromal layers; the oxygen diffusion and ultraviolet (UV) absorption to determine the amount of reactive oxygen species as a function of time and stromal depth...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28057642/accelerated-transepithelial-corneal-cross-linking-for-progressive-keratoconus-a-prospective-study-of-12%C3%A2-months
#17
Wei Aixinjueluo, Tomohiko Usui, Takashi Miyai, Tetsuya Toyono, Toshihiro Sakisaka, Satoru Yamagami
BACKGROUND/AIMS: To evaluate the clinical results of accelerated transepithelial corneal cross-linking (CXL) in Japanese patients with progressive keratoconus (KCN). METHODS: Thirty eyes of 19 patients (16 male, 3 female patients) with progressive KCN were included. The mean age was 24.9±7.0 (range 16-38) years. All patients received ultraviolet A radiation for 3 min at an irradiance of 30 mW/cm(2). Patients were followed up on the first day, at 1 week and 2 weeks, and at 1 month, 3 months, 6 months and 12 months postoperatively...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28035498/accelerated-versus-conventional-corneal-collagen-cross-linking-in-patients-with-keratoconus-an-intrapatient-comparative-study
#18
Mohammad Mehdi Sadoughi, Bahram Einollahi, Alireza Baradaran-Rafii, Danial Roshandel, Hamidreza Hasani, Mehrdad Nazeri
PURPOSE: To compare the outcomes of the conventional and accelerated corneal collagen cross-linking (CXL) in patients with bilateral progressive keratoconus (KC). METHODS: Fifteen consecutive patients with bilateral progressive KC were enrolled. In each patient, the fellow eyes were randomly assigned to the conventional CXL (3 mW/cm(2) for 30 min) or accelerated CXL (ACXL) (9 mW/cm(2) for 10 min) groups. Manifest refraction; uncorrected and corrected distant visual acuity; maximum and mean keratometry; corneal hysteresis and corneal resistance factor; endothelial cell density and morphology; central corneal thickness; and wavefront aberrations were measured before and 12 months after the CXL...
December 29, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28009397/corneal-collagen-crosslinking-for-corneal-ectasias-a-review
#19
REVIEW
David P S O'Brart
PURPOSE: To review the published literature on corneal collagen crosslinking (CXL). METHODS: Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. RESULTS: Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements...
May 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28007116/accelerated-corneal-collagen-crosslinking-technique-efficacy-safety-and-applications
#20
REVIEW
Carla S Medeiros, Natalia T Giacomin, Renata L Bueno, Ramon C Ghanem, Haroldo V Moraes, Marcony R Santhiago
Corneal collagen crosslinking (CXL) is an approach used to increase the biomechanical stability of the stromal tissue. Over the past 10 years, it has been used to halt the progression of ectatic diseases. According to the photochemical law of reciprocity, the same photochemical effect is achieved with reduced illumination time and correspondingly increased irradiation intensity. Several new CXL devices offer high ultraviolet-A irradiation intensity with different time settings. The main purpose of this review was to discuss the current use of different protocols of accelerated CXL and compare the efficacy and safety of accelerated CXL with the efficacy and safety of the established conventional method...
December 2016: Journal of Cataract and Refractive Surgery
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