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https://www.readbyqxmd.com/read/28439417/cell-free-and-intracellular-nucleic-acids-new-non-invasive-biomarkers-to-explore-male-infertility
#1
REVIEW
Anne Boissière, Anna Gala, Alice Ferrières-Hoa, Tiffany Mullet, Solenne Baillet, Amaël Petiton, Antoine Torre, Samir Hamamah
Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28434988/genotyping-of-helicobacter-pylori-shows-high-diversity-of-strains-circulating-in-central-vietnam
#2
Trung Nam Phan, Antonella Santona, Van Huy Tran, Thi Nhu Hoa Tran, Le Van An, Pietro Cappuccinelli, Salvatore Rubino, Bianca Paglietti
In Vietnam, the high prevalence of Helicobacter pylori infection represents a serious health problem. Virulence genes of H. pylori have been associated to increased risk of severe gastrointestinal diseases and the genetic background differs in geographical areas. We investigated cagA and vacA genotypes of H. pylori from dyspeptic patients from central Vietnam and the correlation with clinical outcomes; we also performed sequencing analysis of partial cagA gene. Overall, 84% of strains were cagA-positive, 75% were East-Asian type with a prevalence of vacAs1i1m1 and vacAs1i1m2 genotypes (66...
April 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28433186/characterization-and-thermal-inactivation-kinetics-of-highly-thermostable-ramie-leaf-%C3%AE-amylase
#3
Liqin He, Sung-Hoon Park, Nguyen Dang Hai Dang, Hoa Xo Duong, Thi Phung Cac Duong, Phuong Lan Tran, Jong-Tae Park, Li Ni, Kwan-Hwa Park
We characterized ramie leaf β-amylase, and determined its thermostability and kinetic parameters. The enzyme was purified 53-fold using ammonium sulfate fractionation (40-60% saturation), anion exchange chromatography on DEAE-cellulose and gel permeation chromatography on Superdex-200. The purified enzyme was identified as β-amylase with molecular mass of 42kD. The enzyme displayed Km and kcat values for soluble potato starch of 1.1mg/mL and 7.8s(-1), respectively. The enzyme had a temperature optimum of 65°C, and its activity at 70°C was 92% of that at the optimal temperature after a 15-min incubation...
June 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28432106/prohibitin-induced-obesity-leads-to-anovulation-and-polycystic-ovary-in-mice
#4
Sudharsana Rao Ande, Khanh Hoa Nguyen, Yang Xin Zi Xu, Suresh Mishra
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, the etiology of the disease and the mechanisms by which this disorder progress remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Initially, the female Mito-Ob mice were equally fertile to their wild-type littermates. Mito-Ob mice begin to gain weight after puberty, become significantly obese between 3-6 months of age, and roughly 25% of them become infertile by 9 months of age...
April 21, 2017: Biology Open
https://www.readbyqxmd.com/read/28425426/production-of-red-tilapia-oreochromis-spp-in-floating-cages-in-the-mekong-delta-vietnam-mortality-and-health-management
#5
Annette S Boerlage, Tu Thanh Dung, Tran Thi Hoa, Jeffrey Davidson, Henrik Stryhn, K Larry Hammell
The Mekong Delta in Vietnam is one of the most productive aquaculture regions in the world, in which the red tilapia (Oreochromis spp.) industry is a small-scale industry that mainly supplies local markets in the delta region. Little is known about the frequency of mortality events and health management in this sector. We describe red tilapia floating cage production systems in the Mekong Delta, Vietnam, for the purposes of quantifying mortality and associated production factors, and describing practices that may influence pathogen introduction and spread to and from farms...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28424975/etv-2-activated-proliferation-of-endothelial-cells-and-attenuated-acute-hindlimb-ischemia-in-mice
#6
Phuc Van Pham, Ngoc Bich Vu, Hoa Trong Nguyen, Thuy Thi-Thanh Dao, Ha Thi-Ngan Le, Lan Thi Phi, Oanh Thi-Kieu Nguyen, Ngoc Kim Phan
Ischemia is the reduction of blood flow to tissues by injury of blood vessels. Depending on the sites of tissues and grade of ischemia, ischemia can cause many serious complications. This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia. The role of ETV2 on endothelial cell proliferation was evaluated in vitro. Knockdown of ETV2 expression was done using short hairpin RNA (shRNA) lentiviral viral particles...
April 19, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28424783/peptide-fraction-poh2-exerts-antiadipogenic-activity-through-inhibition-of-c-ebp-%C3%AE-and-ppar-%C3%AE-expression-in-3t3-l1-adipocytes
#7
Thi Tuyet Nhung Nguyen, Thi Thu Ha, Thi Hoa Nguyen, Thi Hien Vu, Nam Hai Truong, Hoang Ha Chu, Dong Van Quyen
Many studies have comprehensively examined the venom of Ophiophagus hannah snake. Its venom comprises different compounds exhibiting a wide range of pharmacological activities. In this investigation, four peptide fractions (PFs), ranging from 3 kDa to 10 kDa, isolated from the Vietnamese snake venom of O. hannah were separated by HPLC and investigated for their inhibitory activity on adipogenesis in 3T3-L1 adipocytes. The most effective PF was then further purified, generating two peptides, pOh1 and pOh2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28419631/tgpl2-a-patatin-like-phospholipase-domain-containing-protein-is-involved-in-the-maintenance-of-apicoplast-lipids-homeostasis-in-toxoplasma
#8
Maude F Lévêque, Laurence Berry, Yoshiki Yamaryo-Botté, Hoa Mai Nguyen, Marine Galera, Cyrille Y Botté, Sébastien Besteiro
Patatin-like phospholipases are involved in numerous cellular functions, including lipid metabolism and membranes remodeling. The patatin-like catalytic domain, whose phospholipase activity relies on a serine-aspartate dyad and an anion binding box, is widely spread among prokaryotes and eukaryotes. We describe TgPL2, a novel patatin-like phospholipase domain-containing protein from the parasitic protist Toxoplasma gondii. TgPL2 is a large protein, in which the key motifs for enzymatic activity are conserved in the patatin-like domain...
April 17, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28412400/prediction-of-losartan-active-carboxylic-acid-metabolite-exposure-following-losartan-administration-using-static-and-physiologically-based-pharmacokinetic-models
#9
Hoa Q Nguyen, Jian Lin, Emi Kimoto, Ernesto Callegari, Susanna Tse, R Scott Obach
The aim of this study was to evaluate a strategy based on static and dynamic physiologically based pharmacokinetic (PBPK) modeling for the prediction of metabolite and parent drug area under the time-concentration curve ratio (AUCm/AUCp) and their PK profiles in humans using in vitro data when active transport processes are involved in disposition. The strategy was applied to losartan and its pharmacologically active metabolite carboxylosartan as test compounds. Hepatobiliary transport including transport-mediated uptake, canilicular and basolateral efflux, and metabolic clearance estimates were obtained from in vitro studies using human liver microsomes and sandwich cultured hepatocytes...
April 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28408464/targetable-kinase-gene-fusions-in-high-risk-b-all-a-study-from-the-children-s-oncology-group
#10
Shalini C Reshmi, Richard C Harvey, Kathryn G Roberts, Eileen Stonerock, Amy Smith, Heather Jenkins, I-Ming Chen, Marc Valentine, Yu Liu, Yongjin Li, Ying Shao, John Easton, Debbie Payne-Turner, Zhaohui Gu, Thai Hoa Tran, Jonathan V Nguyen, Meenakshi Devidas, Yunfeng Dai, Nyla A Heerema, Andrew J Carroll, Elizabeth A Raetz, Michael J Borowitz, Brent L Wood, Anne L Angiolillo, Michael J Burke, Wanda L Salzer, Patrick A Zweidler-McKay, Karen R Rabin, William L Carroll, Jinghui Zhang, Mignon L Loh, Charles G Mullighan, Cheryl L Willman, Julie M Gastier-Foster, Stephen P Hunger
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype characterized by genomic alterations that activate cytokine receptor and kinase signaling. We examined the frequency and spectrum of targetable genetic lesions in a retrospective cohort of 1389 consecutively diagnosed childhood B-ALL patients with high-risk clinical features and/or elevated minimal residual disease at the end of remission induction therapy. The Ph-like gene expression profile was identified in 341 of 1389 patients, 57 of which were excluded from additional analysis because of the presence of BCR-ABL1 (n=46) or ETV6-RUNX1 (n=11)...
April 13, 2017: Blood
https://www.readbyqxmd.com/read/28406248/sensory-defects-and-developmental-delay-among-children-with-congenital-rubella-syndrome
#11
Michiko Toizumi, Giang Thi Huong Nguyen, Hideki Motomura, Thanh Huu Nguyen, Enga Pham, Ken-Ichi Kaneko, Masafumi Uematsu, Hien Anh Thi Nguyen, Duc Anh Dang, Masahiro Hashizume, Lay-Myint Yoshida, Hiroyuki Moriuchi
This study investigated the features of developmental difficulties combined with sensory defects in children with congenital rubella syndrome (CRS). Following a large rubella outbreak in Khanh Hoa Province, Vietnam, in 2011, we enrolled 41 children with CRS from September 2011 through May 2013. Fourteen participants died and six became untraceable by October 2013; the remaining 21 children were followed up from 2013 to 2015. Thirteen and seven participants had hearing and functional ophthalmological impairment, respectively...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405494/overcoming-resistance-to-her2-targeted-therapy-with-a-novel-her2-cd3-bispecific-antibody
#12
Andres Lopez-Albaitero, Hong Xu, Hongfen Guo, Linlin Wang, Zhihao Wu, Hoa Tran, Sarat Chandarlapaty, Maurizio Scaltriti, Yelena Janjigian, Elisa de Stanchina, Nai-Kong V Cheung
T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors. As a member of the HER family of tyrosine kinase receptors, its over-activity confers unfavorable clinical outcome. Targeted therapies directed at this receptor have achieved responses, although development of resistance is common. We explored a novel HER2/CD3 bispecific antibody (HER2-BsAb) platform that while preserving the anti-proliferative effects of trastuzumab, it recruits and activates non-specific circulating T-cells, promoting T cell tumor infiltration and ablating HER2(+) tumors, even when these are resistant to standard HER2-targeted therapies...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28402639/a-simple-approach-for-predicting-the-spin-state-of-homoleptic-fe-ii-tris-diimine-complexes
#13
Hoa Phan, Jeremy J Hrudka, Dilyara Igimbayeva, Latévi M Lawson Daku, Michael Shatruk
We propose a simple method for predicting the spin state of homoleptic complexes of the Fe(II) d6 ion with chelating diimine ligands. The approach is based on the analysis of a single metric parameter within a free (non-coordinated) ligand - the interatomic separation between the N-donor metal-binding sites. An extensive analysis of existing complexes allows the determination of critical N···N distances that dictate the regions of stability for the high-spin and low-spin complexes, as well as the intermediate range in which the magnetic bistability (spin crossover) can be observed...
April 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28396804/impact-of-treatment-decentration-on-higher-order-aberrations-after-smile
#14
Ying Yu, Wenwen Zhang, Xinliang Cheng, Jianru Cai, Hui Chen
Purpose. To evaluate decentration following femtosecond laser small incision lenticule extraction (SMILE) and sub-Bowman keratomileusis (SBK) and its impact on higher-order aberrations (HOAs). Methods. Prospective, nonrandom, and comparison study. There were 96 eyes of 52 patients who received SMILE and 96 eyes of 49 patients who received SBK in this study. Decentration was calculated 6 months after surgery with Pentacam. HOAs and visual acuity after the surgery were examined for patients in both groups before and 6 months after surgery...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28393038/single-step-transepithelial-photorefractive-keratectomy-in-high-myopia-qualitative-and-quantitative-visual-functions
#15
Soheil Adib-Moghaddam, Saeed Soleyman-Jahi, Fatemeh Adili-Aghdam, Samuel Arba Mosquera, Niloofar Hoorshad, Salar Tofighi
AIM: To investigate quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) in high myopia. METHODS: In a prospective interventional case-series, 30 eyes with high myopia (-6.00 to -8.75 D) with (up to -3.00 D) or without astigmatism were enrolled from Bina Eye Hospital, Tehran, Iran. One-step TransPRK was performed with aberration-free aspherical optimized profile and SCHWIND AMARIS 500 laser. One-year follow-up results for refraction, visual acuities, vector analysis, ocular wave-front (OWF) and corneal wave-front (CWF) higher order aberrations (HOA), contrast sensitivity (CS), and post-operative haze were assessed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28388896/comparison-of-ocular-higher-order-aberrations-after-smile-and-wavefront-guided-femtosecond-lasik-for-myopia
#16
Xiaoqin Chen, Yan Wang, Jiamei Zhang, Shun-Nan Yang, Xiaojing Li, Lin Zhang
BACKGROUND: To compare changes in higher-order aberrations (HOAs) following small incision lenticule extraction (SMILE) and wavefront-guided femtosecond laser-assisted in situ keratomileusis (WFG FS-LASIK), and to investigate correlations between preoperative spherical equivalence (SE) and components of HOAs affecting visual quality. METHODS: Sixty-five myopic eyes from 38 patients were enrolled in the study retrospectively, either having undergone SMILE or WFG FS-LASIK...
April 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28385213/peroxidase-mediated-formation-of-corn-fiber-gum-bovine-serum-albumin-conjugates-molecular-and-structural-characterization
#17
Yan Liu, Madhav P Yadav, Hoa K Chau, Shuang Qiu, Hui Zhang, Lijun Yin
Corn fiber gum (CFG) was previously conjugated with bovine serum albumin (BSA) via peroxidase treatment to improve its emulsifying properties. The current study was undertaken to evaluate the molecular characteristics of CFG-BSA conjugates prepared at different CFG/BSA weight ratios of 10:1, 4:1, 1:1, and 1:4. After the peroxidase treatment, CFG-BSA mixtures at weight ratios of 10:1 and 4:1 showed an increase in molecular weight from 200 and 193kDa to 218 and 223kDa respectively. But for CFG-BSA mixtures at weight ratio of 1:4, their molecular weight decreased...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28382729/gold-nanoparticles-in-cardiovascular-imaging
#18
REVIEW
Mariana Varna, Hoa V Xuan, Emmanuel Fort
Although originally applied in the field of oncology, recent results have illustrated the considerable potential of gold nanoparticles (GNPs) in the imaging of cardiovascular diseases (CVDs). CVDs represent the leading cause of mortality and disability in the world. The principal cause underpinning CVDs is atherosclerosis, which develops into mid and large blood vessels, often leading to severe complications. Thanks to their unique physicochemical properties, GNPs have drawn much attention from the research community in cardiovascular imaging...
April 6, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28382693/ambient-stable-radical-cations-diradicaloid-%C3%AF-dimeric-dications-closed-shell-dications-and-diradical-dications-of-methylthio-capped-rylenes
#19
Jishan Wu, Qingbiao Qi, Paula Mayorga Burrezo, Hoa Phan, Tun Seng Herng, Tullimilli Y Gopalakrishna, Wangdong Zeng, Jun Ding, Juan Casado
Radical cations and dications of π-conjugated systems play vital roles in organic electronic devices, organic conductors, and conducting polymers. Their structures, charge and spin distribution, and mechanism of charge transport are of great interest. In this article, radical cations and dications of a series of newly synthesized methylthio-capped rylenes were synthesized and isolated. Their ground-state structures, physical properties, and solid state packing were systematically investigated by various experimental methods such as X-ray crystallographic analysis, UV-vis-NIR absorption, (spectro-) electrochemistry, nuclear magnetic resonance, electron spin resonance, superconducting quantum interference device and Raman spectroscopy, assisted by DFT calculations...
April 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28382635/leaf-water-storage-increases-with-salinity-and-aridity-in-the-mangrove-avicennia-marina-integration-of-leaf-structure-osmotic-adjustment-and-access-to-multiple-water-sources
#20
Hoa T Nguyen, Patrick Meir, Lawren Sack, John R Evans, Rafael S Oliveira, Marilyn C Ball
Leaf structure and water relations were studied in a temperate population of Avicennia marina subsp. australasica along a natural salinity gradient (28 to 49 parts per thousand (ppt)) and compared with two subspecies grown naturally in similar soil salinities to those of subsp. australasica but under different climates: subsp. eucalyptifolia (salinity 30 ppt, wet tropics) and subsp. marina (salinity 46 ppt, arid tropics). Leaf thickness, leaf dry mass per area, and water content increased with salinity and aridity...
April 5, 2017: Plant, Cell & Environment
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