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Marissa B Guzzo, Hoa T Nguyen, Thanh H Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A Wolff, Sam Ogwang, Joseph L Timpona, Soumya Gogula, Michael R Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W Jacobsen, Guo-Fang Zhang, Liem Nguyen
The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine. However, the existence or physiological significance of this phenomenon has been unknown in bacteria, which synthesize folate de novo. Here we identify the methylfolate trap as a novel determinant of the bacterial intrinsic death by sulfonamides, antibiotics that block de novo folate synthesis...
October 2016: PLoS Pathogens
Meng Liao, Haoxing Zhao, Longqian Liu, Qian Li, Yun Dai, Yudong Zhang, Yifeng Zhou
Perceptual learning is considered a potential treatment for amblyopia even in adult patients who have progressed beyond the critical period of visual development because adult amblyopes retain sufficient visual plasticity. When perceptual learning is performed with the correction of high-order aberrations (HOAs), a greater degree of neural plasticity is present in normal adults and those with highly aberrated keratoconic eyes. Because amblyopic eyes show more severe HOAs than normal eyes, it is interesting to study the effects of HOA-corrected visual perceptual learning in amblyopia...
October 18, 2016: Scientific Reports
Negin Amirshekarizadeh, Hassan Hashemi, Ebrahim Jafarzadehpur, Ali Mirzajani, Abbasali Yekta, Mehdi Khabazkhoob
PURPOSE: To determine the effect of cyclopentolate, tropicamide, and artificial tear drops on higher-order aberrations (HOAs) in normal eyes with OPD-Scan III (Nidek Inc., Tokyo, Japan). METHODS: In this study, 189 eyes of individuals aged 20 to 35 years were selected as samples. Inclusion criteria were a corrected visual acuity of 20/20 or better, a minimum size of about 5 mm for the pupil in the dark, hyperopia and myopia less than 5 D, and astigmatism less than 2 D...
September 30, 2016: Eye & Contact Lens
Max Bolun Liu, Thuy Bui Huong, Xuyen Hoang, Lan Doan, Shauna Trinh, Hoa Pham Anh Nguyen, Hai Thanh Le, Ai-Xuan Holterman
BACKGROUND: Biliary atresia is an idiopathic, neonatal liver disease of the bile ducts. The natural evolution of biliary atresia is known in developed countries. This study describes the clinical course of biliary atresia in Vietnam, a developing country. METHODS: Chart reviews were undertaken of patients treated with or without the Kasai procedure between January 2010 and July 2013 at a children's hospital in Vietnam. RESULTS: Of 287 children with biliary atresia, 149 (52%) were treated without the Kasai procedure and 138 (48%) were treated with the Kasai procedure...
October 12, 2016: Surgery
Thông Hua-Huy, Sy Duong-Quy, Hoa Pham, Julien Pansiot, Jean-Christophe Mercier, Olivier Baud, Anh Tuan Dinh-Xuan
Inhaled nitric oxide (iNO) is commonly used in the treatment of very ill pre-term newborns. Previous studies showed that exogenous NO could affect endothelial NO synthase (eNOS) activity and expression in vascular endothelial cell cultures or adult rat models, but this has never been fully described in newborn rat lungs. We therefore aimed to assess the effects of iNO on eNOS expression and activity in newborn rats. Rat pups, post-natal day (P) 0 to P7, and their dams were placed in a chamber containing NO at 5 ppm (iNO-5 ppm group) or 20 ppm (iNO-20 ppm group), or in room air (control group)...
January 2016: ERJ Open Research
Esra Yilmaz, Moritz Fritzenwanker, Nikola Pantchev, Mathias Lendner, Sirichit Wongkamchai, Domenico Otranto, Inge Kroidl, Martin Dennebaum, Thanh Hoa Le, Tran Anh Le, Sabrina Ramünke, Roland Schaper, Georg von Samson-Himmelstjerna, Sven Poppert, Jürgen Krücken
BACKGROUND: Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hongkongensis, has been reported. The present study aimed to compare mitochondrial genomes from these parasites and to obtain population genetic information. METHODS AND FINDINGS: Complete mitochondrial genomes were obtained by PCR and Sanger sequencing or ILLUMINA sequencing for four worms...
October 2016: PLoS Neglected Tropical Diseases
Nobuhiro Takemae, Yugo Shobugawa, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Phuong Duy Thai, Tho Dang Nguyen, Duy Thanh Nguyen, Dung Kim Nguyen, Hoa Thi Do, Thi Quynh Anh Le, Phan Truong Hua, Hung Van Vo, Diep Thi Nguyen, Dang Hoang Nguyen, Yuko Uchida, Reiko Saito, Takehiko Saito
BACKGROUND: Influenza A viruses of swine (IAV-S) cause acute and subclinical respiratory disease. To increase our understanding of the etiology of the subclinical form and thus help prevent the persistence of IAV-S in pig populations, we conducted active virologic surveillance in Vietnam, the second-largest pig-producing country in Asia, from February 2010 to December 2013. RESULTS: From a total of 7034 nasal swabs collected from clinically healthy pigs at 250 farms and 10 slaughterhouses, we isolated 172 IAV-S from swine at the weaning and early-fattening stages...
October 10, 2016: BMC Veterinary Research
Manli Liu, Jianchao Wang, Wen Zhong, Danyang Wang, Yugui Zhou, Quan Liu
PURPOSE: To evaluate the clinical results of suction loss in eyes during small incision lenticule extraction (SMILE). METHODS: This prospective paired-eye case study enrolled 8,490 eyes of 4,296 patients, of which 35 eyes experienced suction loss during the SMILE procedure while being treated for myopia or myopic astigmatism. The eyes with suction loss were re-treated with SMILE, femtosecond laser-assisted LASIK (FS-LASIK), or pseudo SMILE, and the fellow eyes were treated with SMILE...
October 1, 2016: Journal of Refractive Surgery
Ekaterina Ivanova, Philip Lindner, Kien Hoa Ly, Mats Dahlin, Kristofer Vernmark, Gerhard Andersson, Per Carlbring
Acceptance and Commitment Therapy (ACT) can be effective in treating anxiety disorders, yet there has been no study on Internet-delivered ACT for social anxiety disorder (SAD) and panic disorder (PD), nor any study investigating whether therapist guidance is superior to unguided self-help when supplemented with a smartphone application. In the current trial, n=152 participants diagnosed with SAD and/or PD were randomized to therapist-guided or unguided treatment, or a waiting-list control group. Both treatment groups used an Internet-delivered ACT-based treatment program and a smartphone application...
September 30, 2016: Journal of Anxiety Disorders
Bharath Kumar, Abhishek Chakraborty, S N Tripathi, Deepika Bhattu
Non-refractory submicron (NR-PM1) aerosols were measured during the late winter period (February-March) via an Aerodyne High Resolution Time of Flight Aerosols Mass Spectrometer (HR-ToF-AMS) along with Black Carbon (BC) and trace gasses in an industrial city, Kanpur, situated in the Gangetic Plain (GP) of India. The composition of NR-PM1 aerosols was dominated by organics (54%), followed by inorganics (36%), and BC (10%). Source apportionment via Positive Matrix Factorization (PMF) of AMS measured organic aerosols (OAs) revealed 6 factors...
October 12, 2016: Environmental Science. Processes & Impacts
Thanh Hoa Le, Nga Thi Bich Nguyen, Khue Thi Nguyen, Huong Thi Thanh Doan, Do Trung Dung, David Blair
The complete mitochondrial (mt) genome of the trematode Echinochasmus japonicus Tanabe, 1926 was fully determined and annotated. The circular mt molecule of this species is 15,865bp in length, containing 12 protein-coding genes (arranged in the following order: cox3-cob-nad4L-nad4-atp6-nad2-nad1-nad3-cox1-cox2-nad6-nad5), two ribosomal RNA genes (rrnL and rrnS) and 22 transfer RNA genes (trnH; trnQ; trnF; trnM; trnV; trnA; trnD; trnN; trnP; trnI; trnK; trnS1(AGN); trnW; trnT; trnC; trnL1(CUN); trnS2(UCN); trnL2(UUN); trnG; and trnE)...
October 1, 2016: Infection, Genetics and Evolution
Hassan Hashemi, Reza Ghaffari, Mohammad Miraftab, Soheila Asgari
PURPOSE: To compare 18-month outcomes between femtosecond laser-assisted LASIK (femto-LASIK) and photorefractive keratectomy with mitomycin-C (PRK-MMC) for myopia of more than 7.0 D in terms of visual acuity and quality. METHODS: In this comparative nonrandomized clinical trial, 60 eyes from 30 patients (30 eyes in each group) were enrolled. The two procedures were compared in terms of 18-month changes in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent, ocular and corneal higher order aberrations (HOAs), and contrast sensitivity (CS)...
October 3, 2016: International Ophthalmology
Woong-Joo Whang, Young-Sik Yoo, Choun-Ki Joo, Geunyoung Yoon
PURPOSE: To analyze surgically induced refractive change (SIRC) and change in high-order aberration after Raindrop corneal inlay insertion, and assess the extent to which Raindrop corneal inlay insertion could correct presbyopia. DESIGN: Interventional case series. METHODS: 17 patients were included if they had a corneal thickness of 500 μm or greater and a stable manifest spherical equivalent refraction between -0.50 and +1.00 diopters.(D) The Raindrop corneal inlay (ReVision Optics, Lake Forest, CA) was implanted on the stromal bed of a femtosecond laser-assisted generated flap of non-dominant eyes...
September 30, 2016: American Journal of Ophthalmology
Arun Kumar Jain, Chintan Malhotra, Anand Pasari, Pawan Kumar, Majid Moshirfar
PURPOSE: To compare the outcomes of topography-guided and wavefront-optimized treatment in patients having laser in situ keratomileusis (LASIK) for myopia. SETTING: Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. DESIGN: Prospective contralateral-eye case study. METHODS: Patients had topography-guided LASIK in 1 eye and wavefront-optimized LASIK in the contralateral eye using the Customized Refractive Surgery Master software and Mel 80 excimer laser...
September 2016: Journal of Cataract and Refractive Surgery
Huong Thi Thanh Doan, Xuyen Thi Kim Le, Roan Thi Do, Chau Thi Minh Hoang, Khue Thi Nguyen, Thanh Hoa Le
INTRODUCTION: The aim of this study was to identify the genetic characteristics and molecular genotyping of duck hepatitis A virus (DHAV) isolated in Vietnam during 2009-2013. METHODOLOGY: Thirty duckling livers from outbreaks between 2009 and 2013 in seven provinces were collected and identified by polymerase chain reaction (PCR). Then, VP1 genes of eleven positive samples and two attenuated vaccine strains were sequenced and analyzed. RESULTS: Genotypic and phylogenetic analyses indicated that the 13 Vietnamese isolates were classified into two genotypes, DHAV-1 and DHAV-3...
September 30, 2016: Journal of Infection in Developing Countries
Mary M Sweeney, Olga Rass, Patrick S Johnson, Eric C Strain, Meredith S Berry, Hoa T Vo, Marc J Fishman, Cynthia A Munro, George W Rebok, Miriam Z Mintzer, Matthew W Johnson
Individuals with substance use disorders have shown deficits in the ability to implement future intentions, called prospective memory. Deficits in prospective memory and working memory, a critical underlying component of prospective memory, likely contribute to substance use treatment failures. Thus, improvement of prospective memory and working memory in substance use patients is an innovative target for intervention. We sought to develop a feasible and valid prospective memory training program that incorporates working memory training and may serve as a useful adjunct to substance use disorder treatment...
October 2016: Experimental and Clinical Psychopharmacology
Aline Rideau Batista Novais, Hoa Pham, Yohan Van de Looij, Miguel Bernal, Jerome Mairesse, Elodie Zana-Taieb, Marina Colella, Pierre-Henri Jarreau, Julien Pansiot, Florent Dumont, Stéphane Sizonenko, Pierre Gressens, Christiane Charriaut-Marlangue, Mickael Tanter, Charlie Demene, Daniel Vaiman, Olivier Baud
Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms linking poor fetal growth and neurocognitive impairment are unclear. Here, we aimed to correlate changes in gene expression induced by FGR in rats and abnormal cerebral white matter maturation, brain microstructure, and cortical connectivity in vivo. We investigated a model of FGR induced by low-protein-diet malnutrition between embryonic day 0 and birth using an interdisciplinary approach combining advanced brain imaging, in vivo connectivity, microarray analysis of sorted oligodendroglial and microglial cells and histology...
December 2016: Glia
Xiaolei Shi, Chunhua Xu, Hongying Hu, Fang Tang, Lijuan Sun
Meeting the regulatory discharge standards for pulp and paper mill wastewater has become ever more difficult because of its recalcitrant and colored dissolved organic matter (DOM). In this study, the variation of DOM from the secondary effluent of pulp and paper mill wastewater before and after coagulation was investigated based on hydrophobicity/hydrophilicity, apparent molecular weight (MW) and fluorescence. DOM fractions of the secondary effluent were all with the apparent MW <20 kDa. Particularly, the hydrophobic acids (HOA) fraction, mainly composed of humic-like materials, was the major component, and it also had the highest color and SUVA254 (UV254 to dissolved organic carbon ratio)...
September 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Tatsuya Nakayama, Michio Jinnai, Ryuji Kawahara, Khong Thi Diep, Nguyen Nam Thang, Tran Thi Hoa, Le Kieu Hanh, Pham Ngoc Khai, Yoshinori Sumimura, Yoshimasa Yamamoto
Reports of livestock infections with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E) are increasing. Based on interviews conducted over a 6-month period, we found that veterinarians in the Vietnamese province of Thai Binh prefer to prescribe colistin-based drugs (CBD) in chicken farms. We aimed to clarify whether CBD use selects for strains of colistin-resistant ESBL-E. With the cooperation of seven local households, we detected ESBL-E in chickens' feces after treating chickens with CBD...
September 23, 2016: Tropical Animal Health and Production
Fei Wang, Lei Shi, Qing-Yun Xue
BACKGROUND: The relationship between hand osteoarthritis (HOA) and systemic metabolic factors is unclear. The aim of this study was to investigate the prevalence of systemic metabolic factors including obesity, hypertension, diabetes mellitus, and atherosclerosis in symptomatic patients with HOA and the association between these systemic metabolic factors and symptomatic HOA in the Chinese Han population aged 40 years and above. METHODS: A cross-sectional survey was conducted on Chinese Han population aged 40 years and above in six centers in China...
2016: Chinese Medical Journal
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