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higher-order aberrations

Ronaldo Valdir Briani, Marcella Ferraz Pazzinatto, Marina Cabral Waiteman, Danilo de Oliveira Silva, Fábio Mícolis de Azevedo
BACKGROUND: The etiology of patellofemoral pain (PFP) is thought to be the result of increased patellofemoral joint (PFJ) load and aberrant lower extremity mechanics, including altered vertical ground reaction forces (VGRF). However, few studies have investigated the association between an increase in pain and VGRF loading rates in the context of PFP. Thus, this study aimed to investigate the immediate effects of PFJ loading on pain and VGRF loading rate, and to see if there is a link between modification of both pain and VGRF loading rate during stair negotiation...
April 11, 2018: Knee
Motonobu Saito, Tomoyuki Momma, Koji Kono
Targeted therapy against actionable gene mutations shows a significantly higher response rate as well as longer survival compared to conventional chemotherapy, and has become a standard therapy for many cancers. Recent progress in next-generation sequencing (NGS) has enabled to identify huge number of genetic aberrations. Based on sequencing results, patients recommend to undergo targeted therapy or immunotherapy. In cases where there are no available approved drugs for the genetic mutations detected in the patients, it is recommended to be facilitate the registration for the clinical trials...
April 7, 2018: Fukushima Journal of Medical Science
Daniel Pilger, David Homburg, Tobias Brockmann, Necip Torun, Eckart Bertelmann, Christoph von Sonnleithner
PURPOSE: The purpose of this study was to assess the clinical outcome after a bilateral implantation of an extended depth of focus intraocular lens in comparison to a monofocal intraocular lens. SETTING: Department of Ophthalmology, Charité-Medical University Berlin, Germany. PATIENTS AND METHODS: A total of 60 eyes of 30 patients were enrolled in this prospective, single-center study. The cataract patients underwent phacoemulsification with bilateral implantation of a TECNIS® Symfony (Abbott Medical Optics, Santa Ana, CA, USA, 15 patients) or a TECNIS Monofocal ZCB00 (Abbott Medical Optics, Santa Ana, CA, USA, 15 patients)...
April 1, 2018: European Journal of Ophthalmology
Yu-Chi Liu, Jiaxin Wen, Ericia Pei Wen Teo, Geraint P Williams, Nyein Chan Lwin, Jodhbir S Mehta
Purpose: To compare the postoperative higher-order-aberrations (HOAs) after hyperopic small incision lenticule extraction (SMILE), hyperopic laser-assisted in situ keratomileusis ( LASIK), and lenticule implantation for correction of hyperopia. Methods: Eighteen monkeys were divided to six groups: +2.00 D and +4.00 D hyperopic SMILE, +2.00 D and +4.00 D hyperopic LASIK ( n = 6 eyes for each), and lenticule implantation with a -2.00 D and -4.00 D lenticule ( n = 3 eyes for each)...
April 2018: Translational Vision Science & Technology
Samaresh Srivastava, Vaishali Vasavada, Viraj Vasavada, Shail Vasavada, Mamidipudi R Praveen, Rajendra Reddy, Abhay R Vasavada
PURPOSE: To compare the change in ocular higher-order wavefront aberrations (HOAs), visual acuity, and modulation transfer function (MTF) after lens extraction with intraocular lens (IOL) implantation in patients with subluxated lenses. SETTING: Iladevi Cataract & IOL Research Centre, Ahmedabad, India. DESIGN: Prospective case series. METHODS: Eyes with subluxated lenses having lens extraction with IOL implantation were included...
March 31, 2018: Journal of Cataract and Refractive Surgery
Luis Francisco Rossi, Juan Pablo Luaces, Ana Maria Palermo, María Susana Merani, Marta Dolores Mudry
Different concentrations of a glyphosate formulation, Roundup® Full II (66.2% glyphosate) were tested in culture peripheral blood of armadillo Chaetophractus villosus with cytogenetic biomarkers like mitotic index (MI), chromosomal aberrations (CA), sister chromatid exchange (SCE) and cell proliferation kinetics (CPK) by means of replication index. Adults animals of both sexes were exposed to RU at four concentrations ranging from 0.026 mL RU solution to 0.379 mL RU daily in oral treatment with the same volume (0...
March 31, 2018: Ecotoxicology and Environmental Safety
Ali Mahdavi Fard, Rana Daei Sorkhabi, Kamal Nasiri, Arezou Tajlil
OBJECTIVE: The aim of this study was to evaluate the effect of trabeculectomy on ocular higher-order aberrations following surgery in a group of patients with open angle glaucoma. METHODS: In this prospective study, patients with primary open angle glaucoma underwent wavefront aberrometry before trabeculectomy with mitomycin-C. Coma-like, spherical-like, and total ocular higher-order aberrations were measured as root mean square values. The measurements were repeated 1 month and 3 months after the procedure...
2018: Northern Clinics of Istanbul
Mateusz Oleszko, Herbert Gross
The application of freeform elements in optical systems increases the number of variables available for correction. This creates the potential to design compact systems with excellent imaging performance. However, it is non-trivial to determine which configuration of the system to choose and where to place the freeform element to obtain the best design. The knowledge of aberration distribution in the system is very helpful in answering these questions. In the following paper, we analyze Zernike surface contributions to the total wave aberration in non-symmetric freeform mirror systems using the method introduced in [J...
March 20, 2018: Applied Optics
Antonio J Del Águila-Carrasco, Francisco Lara, Paula Bernal-Molina, Resurrección Riquelme-Nicolás, Iván Marín-Franch, José J Esteve-Taboada, Robert Montés-Micó, Philip B Kruger, Norberto López-Gil
PURPOSE: We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics. METHODS: We performed two experiments to test the effects of PHCl on static and on dynamic accommodation in 8 and 6 subjects, respectively. Objective wavefront measurements were recorded of the static accommodation response to a stimulus at different distances or dynamic accommodation response to a sinusoidally moving stimulus (between 1 and 3 D of accommodative demand at 0...
March 27, 2018: Journal of Optometry
Li-Kun Xia, Jing Ma, He-Nan Liu, Ce Shi, Qing Huang
AIM: To compare and calculate the 3-year refractive results, higher-order aberrations (HOAs), contrast sensitivity (CS) and dry eye parameters after small incision lenticule extraction (SMILE) and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for correction of high myopia and myopic astigmatism. METHODS: In this prospective, non-randomized comparative study, 78 eyes with spherical equivalent (SE) of -8.11±1.09 diopters (D) received a SMILE surgery, and 65 eyes with SE of -8...
2018: International Journal of Ophthalmology
Dong Hui Lim, Eui-Sang Chung, Myoung Joon Kim, Tae-Young Chung
AIM: To assess visual quality after presbyopia correction using an aspheric ablation profile and a micro-monovision protocol. METHODS: This is a retrospective interventional study. Fifty-four eyes of 27 patients (mean age, 50.2±7.5y) who underwent presbyopia correction with an aspheric micro-monovision protocol were enrolled. The values of modulation transfer function (MTF) cutoff frequency, Strehl ratio, objective scattering index (OSI) and accommodation range were quantitatively assessed using the HD analyzer...
2018: International Journal of Ophthalmology
Soheila Asgari, Hassan Hashemi
Purpose: To determine topographic and aberrometric changes after accelerated cross-linking (ACXL; 18 mW/cm2 for 5 min) as measured with OPD Scan III (Nidek Inc., Tokyo, Japan) and their repeatability in patients with mild and moderate keratoconus (KCN). Methods: In this prospective study, 25 eyes with mild KCN [Ksteep = 47.24 ± 3.11 diopter (D)] and 20 moderate cases (Ksteep = 52.86 ± 4.39 D) were examined under mesopic conditions (20 lux) twice, 30-45 min apart, at baseline and 6 and 12 months afterwards...
March 2018: Journal of Current Ophthalmology
Karl A Hujsak, Eric W Roth, William Kellogg, Yue Li, Vinayak P Dravid
Technological advances in electron microscopy, particularly improved detectors and aberration correctors, have led to higher throughput and less invasive imaging of materials and biological structures by enhancing signal-to-noise ratios at lower electron exposures. Analytical methods, such as electron energy loss spectroscopy (EELS) and energy dispersive x-ray spectrometry (EDS), have also benefitted and offer a rich set of local elemental and bonding information with nano-or atomic resolution. However, spatially resolved spectrum imaging with EELS and EDS continue to be difficult to scale due to limited detector collection angles or high signal background, requiring hours or even days for full maps...
March 10, 2018: Micron: the International Research and Review Journal for Microscopy
I Maini, I Ivanovski, O Djuric, S G Caraffi, E Errichiello, M Marinelli, F Franchi, V Bizzarri, S Rosato, M Pollazzon, C Gelmini, M Malacarne, C Fusco, G Gargano, S Bernasconi, O Zuffardi, L Garavelli
BACKGROUND: Since 2010, array-CGH (aCGH) has been the first-tier test in the diagnostic approach of children with neurodevelopmental disorders (NDD) or multiple congenital anomalies (MCA) of unknown origin. Its broad application led to the detection of numerous variants of uncertain clinical significance (VOUS). How to appropriately interpret aCGH results represents a challenge for the clinician. METHOD: We present a retrospective study on 293 patients with age range 1 month - 29 years (median 7 years) with NDD and/or MCA and/or dysmorphisms, investigated through aCGH between 2005 and 2016...
March 9, 2018: Italian Journal of Pediatrics
Jiahui Chen, Qinghe Jing, Yating Tang, Dongjin Qian, Yi Lu, Yongxiang Jiang
Marfan syndrome (MFS) is associated with abnormalities of corneal biometric characteristics. We conducted a retrospective case-control study including 55 eyes of the MFS patients with lens subluxation and 53 normal eyes of the control subjects to evaluate the corneal curvature, astigmatism and aberrations using a rotating Scheimpflug camera (Pentacam HR). Compared with the control group, the anterior, posterior, and total corneal curvature were flatter in the MFS group. The anterior and total corneal astigmatism were higher in the MFS patients, whereas the posterior corneal astigmatism was not significantly different between the two groups...
March 6, 2018: Scientific Reports
Montserrat Garcia-Gonzalez, Carmen Bouza-Miguens, Alberto Parafita-Fernandez, Juan Gros-Otero, Rafael Cañones-Zafra, Cesar Villa-Collar, Miguel A Teus
PURPOSE: To compare the 3-month postoperative refractive results and flap thickness homogeneity after correction of myopia using the Intralase femtosecond platform and the Victus dual femtosecond laser platform. SETTING: Novovision Clinic, Madrid, Spain. DESIGN: Prospective case series. METHODS: Eyes treated with a 60 kHz femtosecond laser (Group 1) and eyes treated with a dual femtosecond laser (Group 2) were included...
January 2018: Journal of Cataract and Refractive Surgery
Jie Shen, Frank Spors, Donald Egan, Chunming Liu
Introduction: The peripheral refractive error of the human eye has been hypothesized to be a major stimulus for the development of its central refractive error. Aim: The purpose of this study was to investigate the changes in the peripheral refractive error across horizontal, vertical and two diagonal meridians in emmetropic and low, moderate and high myopic adults. Subjects and methods: Thirty-four adult subjects were recruited and aberration was measured using a modified commercial aberrometer...
2018: Clinical Ophthalmology
Shigeyuki Morishita, Yuji Kohno, Fumio Hosokawa, Kazu Suenaga, Hidetaka Sawada
Higher order geometrical aberration correctors for transmission electron microscopes are essential for atomic-resolution imaging, especially at low-accelerating voltages. We quantitatively calculated the residual aberrations of fifth-order aberration correctors to determine the dominant aberrations. The calculations showed that the sixth-order three-lobe aberration was dominant when fifth-order aberrations were corrected by using the double-hexapole or delta types of aberration correctors. It was also deduced that the sixth-order three-lobe aberration was generally smaller in the delta corrector than in the double-hexapole corrector...
February 21, 2018: Microscopy
Marek Kowalczyk, Marcin Orłowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk, Agnieszka Pedrycz
BACKGROUND: Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can affect the development of several dozen percentages of malignant tumours, including CRC. In the present study, an attempt was made to assess the incidence and growth dynamics of ACF and to determine whether the type of diet affected the development and number of AFC. METHODS: Colonoscopy combined with rectal mucosa staining with 0...
February 21, 2018: BMC Cancer
Irene Sanchez, Sara Ortiz-Toquero, Raul Martin
OBJECTIVE: The VX120 multidiagnostic unit is a multidiagnostic instrument that combines several functions: autorefraction, keratometry, corneal topography, aberrometry, pachymetry, and noncontact tonometry. The purpose of this study was to determine the intrasession repeatability and the intersession reproducibility of all parameters measured by the VX120 multidiagnostic unit in a sample of normal healthy eyes. METHODS: Three repeated measurements in the right eye of the volunteers were taken with VX120...
February 15, 2018: Eye & Contact Lens
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