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higher-order aberrations

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https://www.readbyqxmd.com/read/28211176/peripheral-aberrations-in-adult-hyperopes-emmetropes-and-myopes
#1
Uchechukwu L Osuagwu, Marwan Suheimat, David A Atchison
PURPOSE: To determine differences in peripheral aberrations in hyperopic, emmetropic and myopic groups. METHODS: Cycloplegic peripheral aberrations for 5 mm pupils were measured at 39 locations across 42° × 32° of right eye visual fields with a COAS-HD Hartmann-Shack aberrometer in nine hyperopes (mean age 29 ± 5 years, spherical equivalent refraction M + 1.47 ± 0.58 D), 20 emmetropes (28 ± 7 years, +0.06 ± 0.36 D) and 20 myopes (27 ± 6 years, -2...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28211160/optical-characteristics-of-alvarez-variable-power-spectacles
#2
Hema Radhakrishnan, W Neil Charman
PURPOSE: To establish the optical performance of currently available Alvarez variable-power spectacles in relation to their possible utility for ametropes and presbyopes. METHODS: Two commercial designs of variable-power (variable-focus) spectacles were studied: FocusSpecs and Adlens Adjustables. Using focimetry, power and prism at three different power settings were measured across the aperture of the lenses of each design and local optical quality was explored in more detail using interferometry...
February 17, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28198450/identification-of-methylation-driven-differentially-expressed-stxbp6-as-a-novel-biomarker-in-lung-adenocarcinoma
#3
Govinda Lenka, Mong-Hsun Tsai, Hsin-Chieh Lin, Jen-Hao Hsiao, Yi-Ching Lee, Tzu-Pin Lu, Jang-Ming Lee, Chung-Ping Hsu, Liang-Chuan Lai, Eric Y Chuang
DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene targets as molecular biomarkers for early detection, the survival rate of lung cancer patients is still poor. In order to identify methylation-driven biomarkers, genome-wide changes in DNA methylation and differential expression in 32 pairs of lung adenocarcinoma and adjacent normal lung tissue in non-smoking women were examined. This concurrent analysis identified 21 negatively correlated probes (r ≤ -0...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28168049/photorefractive-keratectomy-for-residual-myopia-after-myopic-laser-in-situ-keratomileusis
#4
Kamal A M Solaiman, Sameh M Fouda, Ashraf Bor'i, Haitham Y Al-Nashar
Purpose. To evaluate the safety, efficacy, and predictability of photorefractive keratectomy (PRK) on the corneal flap for correction of residual myopia following myopic laser in situ keratomileusis (LASIK). Patients and Methods. A retrospective study on eyes retreated by PRK on the corneal flap for residual myopia after LASIK. All eyes had no enough stroma after LASIK sufficient for LASIK enhancement. Data included spherical equivalent (SE), uncorrected and best corrected visual acuity (UCVA and BCVA), central pachymetry, corneal higher order aberrations (HOAs), corneal hysteresis (CH), corneal resistance factor (CRF), and corneal haze...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28156453/frequency-predictors-and-outcomes-of-urine-drug-test-among-patients-with-advanced-cancer-on-chronic-opioid-therapy-at-an-outpatient-supportive-care-clinic
#5
Tonya Edwards, David Hui, Jessica Marie Waletich-Flemming, Suresh K Reddy, Diane D Liu, Jimin Wu, Eduardo Bruera
: 94 Background: Data on the utilization and outcomes of urine drug tests (UDT) among advanced cancer patients is limited. The main objective of this study was to determine the factors associated with UDT ordering and results in advanced cancer outpatients. METHODS: A retrospective chart review of 1058 patients seen from March 2014 to November 2015 at an outpatient supportive care clinic was conducted. Sixty-one patients on chronic opioid therapy who underwent UDT were identified...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152553/the-effect-of-aberrations-on-objectively-assessed-image-quality-and-depth-of-focus
#6
Antonio J Del Águila-Carrasco, Scott A Read, Robert Montés-Micó, D Robert Iskander
The effects of aberrations on image quality and the objectively assessed depth of focus (DoF) were studied. Aberrometry data from 80 young subjects with a range of refractive errors was used for computing the visual Strehl ratio based on the optical transfer function (VSOTF), and then, through-focus simulations were performed in order to calculate the objective DoF (using two different relative thresholds of 50% and 80%; and two different pupil diameters) and the image quality (the peak VSOTF). Both lower order astigmatism and higher order aberration (HOA) terms up to the fifth radial order were considered...
February 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28150433/impaired-maternal-hemodynamics-in-morbidly-obese-women-a-case-control-study
#7
D Vinayagam, J Gutierrez, J Binder, E Mantovani, B Thilaganathan, A Khalil
AIM: Maternal obesity is associated with significant pregnancy complications and is a risk factor for the development of hypertensive disorders of pregnancy as well as other adverse outcomes. There are few data regarding the hemodynamic aberrations observed in maternal obesity. The aim of this study was to investigate maternal hemodynamics in morbidly obese pregnant women. METHODS: This was a prospective, case-control study of morbidly obese women (BMI >40 kg/m(2) ) and controls (BMI 20-29...
February 2, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28138309/polymorphisms-in-microrna-binding-sites-predict-colorectal-cancer-survival
#8
Ying-Pi Yang, Wen-Chien Ting, Lu-Min Chen, Te-Ling Lu, Bo-Ying Bao
Background: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers. We hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer. Methods: Sixteen common SNPs within miRNA target sites were identified, and the association between these SNPs and overall survival was assessed in colorectal cancer patients using Kaplan-Meier analysis, Cox regression model, and survival tree analysis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28133542/corneal-topographic-and-aberrometric-measurements-obtained-with-a-multidiagnostic-device-in-healthy-eyes-intrasession-repeatability
#9
David P Piñero, Alberto López-Navarro, Inmaculada Cabezos, Dolores de Fez, María T Caballero, Vicent J Camps
Purpose. To evaluate the intrasession repeatability of corneal curvature, eccentricity, and aberrometric measurements obtained with a multidiagnostic device in healthy eyes. Methods. This study enrolled 107 eyes of 107 patients ranging in age from 23 to 65 years. All of them underwent a complete anterior segment examination with the VX120 system (Visionix-Luneau Technologies, Chartres, France). Three consecutive measurements were obtained. The within-subject standard deviation (Sw ), intrasubject precision (1...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28123435/transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-in-the-sera-of-postmenopausal-osteoporotic-females
#10
Aazam Faraji, Shabnam Abtahi, Abbas Ghaderi, Alamtaj Samsami Dehaghani
BACKGROUND: Postmenopausal osteoporosis is a major cause of morbidity in postmenopausal females. Transforming growth factor β1 (TGF-β1) and interleukin 18 (IL-18) play complex roles in normal bone metabolism, and in pathophysiology of postmenopausal osteoporosis. OBJECTIVES: The aim of this study was to design an analytic cross sectional study in order to further clarify the role of TGF-β1 and IL-18 in osteoporosis of postmenopausal females. METHODS: A cross sectional study including 65 postmenopausal osteoporotic females as cases and 69 postmenopausal females of similar age without osteoporosis as controls was conducted...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28120116/urine-drug-screen-findings-among-ambulatory-oncology-patients-in-a-supportive-care-clinic
#11
Sherri Rauenzahn, Adam Sima, Brian Cassel, Danielle Noreika, Teny Henry Gomez, Lynn Ryan, Carl E Wolf, Luke Legakis, Egidio Del Fabbro
PURPOSE: Professional organizations provide no guidelines regarding assessment and management of opioid abuse risk in cancer. Universal precautions (UP) developed for non-cancer pain, include assessments for aberrant behavior, screening questionnaires, and urine drug screens (UDS). The role of UDS for identifying opioid abuse risk in cancer is uncertain. Our aim is to characterize inappropriate UDS, and identify a potential role for UDS in therapeutic decision-making. METHODS: An observational retrospective chart review of 232 consecutive supportive care clinic patients were seen during the study...
January 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28113715/spatio-temporal-rich-model-based-video-steganalysis-on-cross-sections-of-motion-vector-planes
#12
Kasim Tasdemir, Fatih Kurugollu, Sakir Sezer
A rich model based motion vector steganalysis benefiting from both temporal and spatial correlations of motion vectors is proposed in this work. The proposed steganalysis method has a substantially superior detection accuracy than the previous methods, even the targeted ones. The improvement in detection accuracy lies in several novel approaches introduced in this work. Firstly, it is shown that there is a strong correlation, not only spatially but also temporally, among neighbouring motion vectors for longer distances...
May 11, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28096651/effects-of-3-diquafosol-sodium-ophthalmic-solution-on-higher-order-aberrations-in-patients-diagnosed-with-dry-eye-after-cataract-surgery
#13
Yasushi Inoue, Shintarou Ochi
PURPOSE: To evaluate the effects of diquafosol sodium ophthalmic solution 3% (DQS) and artificial tears (AT) on higher-order aberrations (HOAs) in patients with dry eye after cataract surgery. DESIGN: This was a post hoc analysis of a previously conducted randomized clinical study. METHODS: Fifty-nine eyes from 42 patients (17 males and 25 females, aged 72.6±8.0 years) with verified or suspected dry eye at 4 weeks after cataract surgery were evaluated...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28087167/lingering-questions-about-enhancer-rna-and-enhancer-transcription-coupled-genomic-instability
#14
REVIEW
Gerson Rothschild, Uttiya Basu
Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes...
February 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28076565/effect-of-corneal-biomechanical-properties-on-surgically-induced-astigmatism-and-higher-order-aberrations-after-cataract-surgery
#15
Mustafa Koç, Çağrı İlhan, Yaran Koban, Kemal Özülken, İrfan Durukan, Pelin Yılmazbaş
Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28068441/changes-in-astigmatism-densitometry-and-aberrations-after-smile-for-low-to-high-myopic-astigmatism-a-12-month-prospective-study
#16
Iben Bach Pedersen, Anders Ivarsen, Jesper Hjortdal
PURPOSE: To evaluate 12-month changes in refraction, visual outcome, corneal densitometry, and postoperative aberrations after small incision lenticule extraction (SMILE) for myopic astigmatism. METHODS: This 12-month prospective clinical trial comprised 101 eyes (101 patients) treated with SMILE for myopic astigmatism with cylinder of 0.75 to 4.00 diopters (D). The preoperative, 1-week, and 1-, 3-, 6-, 9-, and 12-month examinations included measurement of manifest refraction, uncorrected distance visual acuity (UDVA), and corrected (CDVA) distance visual acuity...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068440/a-prospective-study-to-compare-visual-outcomes-between-wavefront-optimized-and-topography-guided-ablation-profiles-in-contralateral-eyes-with-myopia
#17
Rohit Shetty, Rushad Shroff, Kalyani Deshpande, Roshan Gowda, Sumeet Lahane, Chaitra Jayadev
PURPOSE: To analyze refractive outcomes of wavefront-optimized (WFO) ablation and topography-guided custom ablation (TCAT) profiles using the Allegretto Wave excimer laser platform (Alcon Laboratories, Inc., Fort Worth, TX) in the treatment of myopia. METHODS: Sixty eyes of 30 patients who underwent LASIK were included in this prospective interventional study. WFO ablation was performed in one eye (WFO group) and TCAT in the fellow eye (TCAT group). The WaveLight FS200 femtosecond laser (Alcon Laboratories, Inc...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068407/significant-association-of-urinary-toxic-metals-and-autism-related-symptoms-a-nonlinear-statistical-analysis-with-cross-validation
#18
James Adams, Daniel P Howsmon, Uwe Kruger, Elizabeth Geis, Eva Gehn, Valeria Fimbres, Elena Pollard, Jessica Mitchell, Julie Ingram, Robert Hellmers, David Quig, Juergen Hahn
INTRODUCTION: A number of previous studies examined a possible association of toxic metals and autism, and over half of those studies suggest that toxic metal levels are different in individuals with Autism Spectrum Disorders (ASD). Additionally, several studies found that those levels correlate with the severity of ASD. METHODS: In order to further investigate these points, this paper performs the most detailed statistical analysis to date of a data set in this field...
2017: PloS One
https://www.readbyqxmd.com/read/28060337/using-rna-sequencing-to-detect-novel-splice-variants-related-to-drug-resistance-in-in-vitro-cancer-models
#19
Rocco Sciarrillo, Anna Wojtuszkiewicz, Irsan E Kooi, Valentina E Gómez, Ugo Boggi, Gerrit Jansen, Gert-Jan Kaspers, Jacqueline Cloos, Elisa Giovannetti
Drug resistance remains a major problem in the treatment of cancer for both hematological malignancies and solid tumors. Intrinsic or acquired resistance can be caused by a range of mechanisms, including increased drug elimination, decreased drug uptake, drug inactivation and alterations of drug targets. Recent data showed that other than by well-known genetic (mutation, amplification) and epigenetic (DNA hypermethylation, histone post-translational modification) modifications, drug resistance mechanisms might also be regulated by splicing aberrations...
December 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28060146/combined-effect-of-ocular-and-multifocal-contact-lens-induced-aberrations-on-visual-performance-center-distance-versus-center-near-design
#20
Daniela Lopes-Ferreira, Paulo Fernandes, António Queirós, José M González-Meijome
PURPOSE: To evaluate the combined effects of inherent ocular aberrations and induced aberrations with a multifocal soft contact lens (MFCL) after 15 days of lens wear in presbyopic participants and their influence on visual performance at distance and near under high and low contrast conditions. METHODS: Forty presbyopic participants (mean age, 48.7±3.4) presenting a mean addition of 1.53±0.58 D were fitted with Biofinity Multifocal (CooperVision) and included in the study...
January 4, 2017: Eye & Contact Lens
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