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higher-order aberrations

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https://www.readbyqxmd.com/read/28532938/posterior-corneal-shape-comparison-of-height-data-from-3-corneal-topographers
#1
Tim de Jong, Matthew T Sheehan, Steven A Koopmans, Nomdo M Jansonius
PURPOSE: To compare the ability of 3 clinical corneal topographers to describe the posterior corneal shape. SETTING: University Medical Center Groningen, the Netherlands. DESIGN: Prospective observational study. METHODS: Corneas of healthy participants were measured twice with a dual Scheimpflug instrument (Galilei G2), a scanning-slit system (Orbscan IIz), and a single Scheimpflug instrument (Pentacam HR). Height data describing the posterior corneal shape were fit with Zernike polynomials...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28524133/-wavefront-aberrations-and-accommodation-in-myopes-and-hyperopes
#2
V V Neroev, E P Tarutta, S G Arutyunyan, A T Khandzhyan, N V Khodzhabekyan
AIM: to comparatively investigate accommodation, pseudoaccommodation, and higher-order aberrations in children and young adults with myopia and hyperopia. MATERIAL AND METHODS: A total of 39 myopic (the mean error of (-)5.2±1.5 diopters) and 53 hyperopic (the mean error of (+)3.1±1.15 diopters) eyes of 46 patients aged 5-20 years (11.6±0.6 years on average) were enrolled. Examination included evaluation of the objective accommodative response, relative accommodation reserves, pseudoaccommodation volume (calculated as the difference between the (+)3...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28520595/decreased-visual-acuity-by-an-irregular-corneal-posterior-surface-after-repeat-descemet-stripping-automated-endothelial-keratoplasty
#3
Hiroyuki Yazu, Takefumi Yamaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To investigate the impact of higher-order aberrations (HOAs) on visual acuity after repeat Descemet stripping automated endothelial keratoplasty (DSAEK) in the same eyes. METHODS: This retrospective comparative case series includes 23 patients who underwent DSAEK twice in the same eyes (46 DSAEK in total). We evaluated the HOAs of the anterior and posterior corneal surfaces, and total cornea using the Fourier analysis data from anterior segment optical coherence tomography...
May 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28515010/aberrant-network-activity-in-schizophrenia
#4
REVIEW
Mark J Hunt, Nancy J Kopell, Roger D Traub, Miles A Whittington
Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology...
May 14, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28503438/comparison-of-visual-effects-of-fs-lasik-for-myopia-centered-on-the-coaxially-sighted-corneal-light-reflex-or-the-line-of-sight
#5
Jing Zhang, Shi-Sheng Zhang, Qin Yu, Jing-Cai Lian
AIM: To compare visual quality after femtosecond laser in situ keratomileusis (FS-LASIK), between the coaxially sighted corneal light reflex (CSCLR) group and conventional ablation line of sight (LOS) group. METHODS: In total, 243 eyes (122 patients) were treated with centration on the CSCLR (visual axis) and 238 eyes (119 patients) treated with centration on the pupil center (LOS). Postoperative outcomes [uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA)], safety index, efficacy index, refractive outcome, ablation center distance from the visual axis, corneal high-order aberrations, subjective discomfort glare and shadowing incidence rate, and contrast sensitivity at 1, 3, and 6mo were measured and compared...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503437/comparison-of-postoperative-optical-quality-according-to-the-degree-of-decentering-of-v4c-implantable-collamer-lens
#6
Min Ji Park, Hye Min Jeon, Kyoung Heon Lee, Sang Youp Han
AIM: To evaluate the clinical outcomes of V4c implantable collamer lens (Hole ICL) implantation with regard to the optical quality assessed according to different degrees of decentering. METHODS: This included 49 eyes that received conventional ICL and 94 eyes that received Hole ICL. The eyes that received Hole ICL were divided into three groups according to the degree of decentering: group 1, central hole within 1 hole diameter (HD) from the pupil center; group 2, central hole within 1 HD to 2 HD; and group 3, central hole within 2 HD to 3 HD...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28501948/corneal-tomography-and-biomechanics-in-primary-pterygium
#7
M Vanathi, Sahil Goel, Anita Ganger, Tushar Agarwal, T Dada, Sudarshan Khokhar
PURPOSE: To study the Scheimpflug's imaging and corneal biomechanics in primary pterygium. METHODS: A prospective observational study of 55 patients with unilateral primary nasal pterygium was done. The normal fellow eyes of patients with pterygium were taken as controls. Clinical parameters noted included visual acuity, values of corneal curvature by doing Scheimpflug imaging, wavefront aberrations in terms of higher and lower-order aberrations and corneal hysteresis (CH) as well as corneal resistance factor (CRF) values by using ocular response analyzer...
May 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28486724/noncontact-quantification-of-topography-of-anterior-corneal-surface-and-bowman-s-layer-with-high-speed-oct
#8
Himanshu Matalia, Mathew Francis, Tarun Gangil, Rachana S Chandapura, Mathew Kurian, Rohit Shetty, Everette Jacob Remington Nelson, Abhijit Sinha Roy
PURPOSE: To quantify keratometry and wavefront aberration of the anterior corneal surface and epithelium-Bowman's layer interface using anterior segment optical coherence tomography (OCT). METHODS: Twenty-five normal eyes and 25 eyes with keratoconus were retrospectively analyzed. The anterior corneal edge and epithelium-Bowman's layer interface were segmented from 12 distortion-corrected OCT B-scans. Axial tangential curvatures and wavefront aberration were calculated by ray tracing and 6th order Zernike analyses...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28477155/the-cuticular-nature-of-corneal-lenses-in-drosophila-melanogaster
#9
Aaron L Stahl, Mark Charlton-Perkins, Elke K Buschbeck, Tiffany A Cook
The dioptric visual system relies on precisely focusing lenses that project light onto a neural retina. While the proteins that constitute the lenses of many vertebrates are relatively well characterized, less is known about the proteins that constitute invertebrate lenses, especially the lens facets in insect compound eyes. To address this question, we used mass spectrophotometry to define the major proteins that comprise the corneal lenses from the adult Drosophila melanogaster compound eye. This led to the identification of four cuticular proteins: two previously identified lens proteins, drosocrystallin and retinin, and two newly identified proteins, Cpr66D and Cpr72Ec...
May 5, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28463335/induced-axial-and-lateral-color-surface-contributions
#10
Andrea Berner, Thomas Nobis, Herbert Gross
Induced aberrations in general are higher-order aberrations caused by ray perturbations of lower order, picked up in the preceding optical system. Therefore, in the case of color aberrations, induced influences can already be observed at the second order. They are generated by the preexisting first-order axial and lateral color. The analysis of relevant designs surface by surface to identify performance dominating lenses is a key method for understanding and optimizing those systems. Hence, in this paper a formula for the surface contribution of axial and lateral color including second-order terms is derived and discussed differentiating between intrinsic and induced parts...
May 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28452081/heightened-brain-response-to-pain-anticipation-in-high-functioning-adults-with-autism-spectrum-disorder
#11
Xiaosi Gu, Thomas J Zhou, Evdokia Anagnostou, Latha Soorya, Alexander Kolevzon, Patrick R Hof, Jin Fan
Autism spectrum disorder (ASD) is marked by both socio-communicative difficulties and abnormalities in sensory processing. Much of the work on sensory deficits in ASD has focused on tactile sensations and the perceptual aspects of somatosensation, such as encoding of stimulus intensity and location. Although aberrant pain processing has often been noted in clinical observations of patients with ASD, it remains largely uninvestigated. Importantly, the neural mechanism underlying higher-order cognitive aspects of pain processing such as pain anticipation also remains unknown...
April 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28440441/preliminary-analysis-of-the-association-between-methylation-of-the-ace2-promoter-and-essential-hypertension
#12
Rui Fan, Shu-Qi Mao, Tian-Lun Gu, Fa-De Zhong, Min-Li Gong, Ling-Mei Hao, Feng-Ying Yin, Chang-Zheng Dong, Li-Na Zhang
The aim of the present study was to investigate whether methylation of the angiotensin I converting enzyme 2 (ACE2) promoter increases the risk of essential hypertension (EH). A total of 96 patients with EH were recruited and 96 sex‑ and age‑matched healthy controls. Methylation of 5 CpG dinucleotides in the ACE2 promoter was quantified using bisulfite pyrosequencing. Logistic regression and multiple linear regression were used to adjust for confounding factors and the generalized multifactor dimensionality reduction (GMDR) method was applied to investigate high‑order interactions...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28435324/symptomatic-central-nervous-system-involvement-in-adult-patients-with-acute-myeloid-leukemia
#13
Nael Alakel, Friedrich Stölzel, Brigitte Mohr, Michael Kramer, Uta Oelschlägel, Christoph Röllig, Martin Bornhäuser, Gerhard Ehninger, Markus Schaich
INTRODUCTION: Acute myeloid leukemia (AML) rarely involves the central nervous system (CNS). Little is known about the clinical course in adult AML patients since most studies examined pediatric patients. Therefore, this study analyzed the data of patients treated in three prospective trials of the "Study Alliance Leukemia" (SAL) study group for CNS involvement. METHODS: In all, 3,261 AML patients included in the prospective AML96, AML2003, and AML60+ trials of the SAL study group were analyzed...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28433446/functional-magnetic-resonance-imaging-to-assess-the-neurobehavioral-impact-of-dysphotopsia-with-multifocal-intraocular-lenses
#14
Andreia M Rosa, Ângela C Miranda, Miguel Patrício, Colm McAlinden, Fátima L Silva, Joaquim N Murta, Miguel Castelo-Branco
PURPOSE: To investigate the association between dysphotopsia and neural responses in visual and higher-level cortical regions in patients who recently received multifocal intraocular lens (IOL) implants. DESIGN: Cross-sectional study. PARTICIPANTS: Thirty patients 3 to 4 weeks after bilateral cataract surgery with diffractive IOL implantation and 15 age- and gender-matched control subjects. METHODS: Functional magnetic resonance imaging (fMRI) was performed when participants viewed low-contrast grating stimuli...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28427322/dental-pulp-pluripotent-like-stem-cells-dppsc-a-new-stem-cell-population-with-chromosomal-stability-and-osteogenic-capacity-for-biomaterials-evaluation
#15
Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori, Maher Atari
BACKGROUND: Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models. Frequently, immortalized osteoblastic cell lines are used in these studies. However, their uncontrolled proliferation rate, phenotypic changes or aberrations in mitotic processes limits their use in long-term investigations. Recently, we described a new pluripotent-like subpopulation of dental pulp stem cells derived from the third molars (DPPSC) that shows genetic stability and shares some pluripotent characteristics with embryonic stem cells...
April 21, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28423190/the-clinical-utility-of-genome-wide-non-invasive-prenatal-screening
#16
Francesco Fiorentino, Sara Bono, Francesca Pizzuti, Sara Duca, Arianna Polverari, Monica Faieta, Marina Baldi, Laura Diano, Francesca Spinella
OBJECTIVE: In this study, we expanded conventional cell-free fetal DNA(cfDNA)-based non-invasive prenatal testing(NIPT) to cover the entire genome. We aimed to compare the performance of the two test in a large general population of pregnant women, in order to assess the clinical utility of the genome-wide screening. METHOD: Genome-wide cfDNA analysis was offered to 12.114 pregnant women undergoing NIPT for common fetal aneuploidy. Sequencing data were analyzed using an algorithm optimized to identify aneuploidies and subchromosomal aberrations...
April 17, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28423035/genetic-profiling-of-putative-breast-cancer-stem-cells-from-malignant-pleural-effusions
#17
Verena Tiran, Stefanie Stanzer, Ellen Heitzer, Michael Meilinger, Christopher Rossmann, Sigurd Lax, Oleksiy Tsybrovskyy, Nadia Dandachi, Marija Balic
A common symptom during late stage breast cancer disease is pleural effusion, which is related to poor prognosis. Malignant cells can be detected in pleural effusions indicating metastatic spread from the primary tumor site. Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties. For the present study, pleural effusion aspirates from 17 metastatic breast cancer patients were processed to propagate CSCs in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28418084/epstein-barr-virus-infection-induces-genome-wide-de-novo-dna-methylation-in-non-neoplastic-gastric-epithelial-cells
#18
Keisuke Matsusaka, Sayaka Funata, Masaki Fukuyo, Yasuyuki Seto, Hiroyuki Aburatani, Masashi Fukayama, Atsushi Kaneda
Epstein-Barr virus (EBV)-positive gastric cancer (GC) shows a higher DNA methylation epigenotype. EBV infection can causally induce genome-wide aberrant DNA methylation, as previously demonstrated by in vitro infection experiments in the low-methylation GC cell line MKN7. However, whether EBV exerts DNA methylation remodelling properties in non-neoplastic epithelial cells remains unclear. We here performed post-infection time-series DNA methylation analyses using the immortalised normal gastric epithelial cell line, GES1...
April 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28407166/evaluation-of-the-true-wavefront-aberrations-in-eyes-implanted-with-a-rotationally-asymmetric-multifocal-intraocular-lens
#19
Vyas Akondi, Pablo Pérez-Merino, Eduardo Martinez-Enriquez, Carlos Dorronsoro, Nicolás Alejandre, Ignacio Jiménez-Alfaro, Susana Marcos
PURPOSE: Standard evaluation of aberrations from wavefront slope measurements in patients implanted with a rotationally asymmetric multifocal intraocular lens (IOL), the Lentis Mplus (Oculentis GmbH, Berlin, Germany), results in large magnitude primary vertical coma, which is attributed to the intrinsic IOL design. The new proposed method analyzes aberrometry data, allowing disentangling the IOL power pupillary distribution from the true higher order aberrations of the eye. METHODS: The new method of wavefront reconstruction uses retinal spots obtained at both the near and far foci...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28396804/impact-of-treatment-decentration-on-higher-order-aberrations-after-smile
#20
Ying Yu, Wenwen Zhang, Xinliang Cheng, Jianru Cai, Hui Chen
Purpose. To evaluate decentration following femtosecond laser small incision lenticule extraction (SMILE) and sub-Bowman keratomileusis (SBK) and its impact on higher-order aberrations (HOAs). Methods. Prospective, nonrandom, and comparison study. There were 96 eyes of 52 patients who received SMILE and 96 eyes of 49 patients who received SBK in this study. Decentration was calculated 6 months after surgery with Pentacam. HOAs and visual acuity after the surgery were examined for patients in both groups before and 6 months after surgery...
2017: Journal of Ophthalmology
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