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https://www.readbyqxmd.com/read/28640128/association-between-polymorphic-cag-repeat-lengths-in-the-androgen-receptor-gene-and-susceptibility-to-prostate-cancer-a-systematic-review-and-meta-analysis
#1
Zhiqiang Qin, Xiao Li, Peng Han, Yuxiao Zheng, Hanyu Liu, Jingyuan Tang, Chengdi Yang, Jianzhong Zhang, Kunpeng Wang, Xiaokang Qi, Min Tang, Wei Wang, Wei Zhang
BACKGROUND: Previous studies have been conducted to reveal the relationship between androgen receptor CAG polymorphism and risk of prostate cancer, yet the results were elusive and controversial. Thus, this meta-analysis was performed to clarify this association. METHODS: To obtain the relevant available studies, online databases PubMed, Embase, and Web of science were searched until September 1st, 2016. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28623628/does-patient-preference-measurement-in-decision-aids-improve-decisional-conflict-a-randomized-trial-in-men-with-prostate-cancer
#2
Joseph D Shirk, Catherine M Crespi, Josemanuel D Saucedo, Sylvia Lambrechts, Ely Dahan, Robert Kaplan, Christopher Saigal
BACKGROUND: Shared decision making (SDM) has been advocated as an approach to medical decision making that can improve decisional quality. Decision aids are tools that facilitate SDM in the context of limited physician time; however, many decision aids do not incorporate preference measurement. OBJECTIVES: We aim to understand whether adding preference measurement to a standard patient educational intervention improves decisional quality and is feasible in a busy clinical setting...
June 16, 2017: Patient
https://www.readbyqxmd.com/read/28600706/effects-of-resistance-exercise-in-prostate-cancer-patients-a-meta-analysis
#3
REVIEW
M Keilani, T Hasenoehrl, L Baumann, R Ristl, M Schwarz, M Marhold, T Sedghi Komandj, R Crevenna
PURPOSE: The aim of the present meta-analysis was to quantify effects of resistance exercise (RE) on physical performance and function, body composition, health-related quality of life (HRQoL), and fatigue in patients with prostate cancer. METHODS: Trial data were obtained from the databases PubMed, MEDLINE, EMBASE, SCOPUS, and the Cochrane Library as of inception to 31st of December 2016. Thirty-two trials with 1199 patients were included. Results that were measured by using the same assessment method in five or more of the original studies were pooled in a meta-analysis...
June 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28590314/novel-imaging-in-advanced-prostate-cancer
#4
Hanan Goldberg, Robert J Hamilton
PURPOSE OF REVIEW: Prostate cancer (PCa) is the most commonly diagnosed noncutaneous cancer and second leading cause of death in men. Imaging evaluation of PCa is challenging because of the prostate's deep pelvic location, its complex zonal anatomy and its multifocal nature. Novel imaging modalities are needed to improve detection, reassessment in biochemical relapse, and disease progression in advanced metastatic stages. RECENT FINDINGS: Current imaging modalities have distinct strengths...
June 3, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28585779/the-impact-of-initial-cancer-stage-on-the-incidence-of-venous-thromboembolism-the-scandinavian-thrombosis-and-cancer-stac-cohort
#5
I L Gade, S K Braekkan, I A Naess, J-B Hansenx, S C Cannegieter, K Overvad, H Jensvoll, J Hammerstrøm, K Blix, A Tjønneland, S R Kristensen, M T Severinsen
BACKGROUND: Absolute measures of the impact of cancer stage on the incidence of venous thromboembolism (VTE) in distinct cancer types have not been investigated in a large population based cohort study. OBJECTIVES: To investigate differences in incidence rates of objectively confirmed VTE according to development of cancer in a large population based cohort study. Cancer type and stage at the time of diagnosis was taken into account. PATIENTS AND METHODS: The Scandinavian Thrombosis and Cancer cohort includes data regarding cancer types, stages and objectively confirmed VTE diagnoses among 144,952 participants followed from 1993 through 2012...
June 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28560056/maintaining-a-regular-physical-activity-aggravates-intramuscular-tumor-growth-in-an-orthotopic-liposarcoma-model
#6
Mohamad Assi, Frédéric Derbré, Luz Lefeuvre-Orfila, Dany Saligaut, Nathalie Stock, Mickael Ropars, Amélie Rébillard
Today, care teams within cancer centers encourage patients to be physically active, after diagnosis, based on data obtained mainly from breast, colon and prostate cancer. Intriguingly, the impact of physical activity (PA) on intramuscular tumors (e.g. sarcomas) has not been specifically addressed and, thus, could be mistakenly confounded with other cancers. In this preclinical study we assessed the impact of PA on intramuscular liposarcoma (LS) evolution. Four-week-old nude male mice were active by voluntary running on wheels, for six weeks...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28557849/monitoring-resistance-exercise-intensity-via-rpe-in-previously-untrained-patients-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#7
C M Fairman, R L LaFountain, A R Lucas, B C Focht
Exercise has been shown to be safe and effective for prostate cancer (PrCa) patients. The monitoring of resistance exercise (RE) intensity is an emerging area of interest in RE prescription. Rating of perceived exertion (RPE) is one of the most commonly used methods, but has not yet been validated in this population. Thus, the purpose of this study was to examine the relationship between RPE and RE intensity in PrCa. Data for this study were abstracted from baseline upper and lower body strength assessments from two previous trials (IDEA-P; Livestrong) in our laboratory investigating functional outcomes in PrCa patients undergoing androgen deprivation therapy (ADT)...
May 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28489754/relationship-between-srd5a2-rs9282858-polymorphism-and-the-susceptibility-of-prostate-cancer-a-meta-analysis-based-on-20-publications
#8
Cheng Fang, Zhong-Qiang Guo, Xiao-Yan Chen, Tong-Zu Liu, Xian-Tao Zeng, Xing-Huan Wang
The pathogenetic mechanism of prostate cancer (PCa) has not been understood completely, and gene polymorphisms have been demonstrated to play a critical role in the course. It has been reported that rs9282858 polymorphism of steroid 5-α-reductase type 2 (SRD5A2) may affect the susceptibility of PCa, but some researches showed different results. We therefore carried out a meta-analysis to clarify this relationship.Relevant studies were identified through PubMed and Chinese National Knowledge Infrastructure databases concerning the association between SRD5A2 rs9282858 polymorphism and PCa...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28479341/towards-intrinsic-r2-imaging-in-the-prostate-at-3-and-7tesla
#9
Mariska P Luttje, Laurens D van Buuren, Peter R Luijten, Marco van Vulpen, Uulke A van der Heide, Dennis W J Klomp
PURPOSE: Hypoxia is an important marker for resistance to therapy. In this study, we quantify the macroscopic effects of R2* mapping in prostate cancer patients incorporating susceptibility matching and field strengths effects. MATERIALS AND METHODS: 91 patients were scanned without endorectal coil (ERC) at 3T. Only when rectal gas was absent, data was included for analysis. Another group of 10 patients was scanned using a susceptibility matched ERC. To assess the residual contamination of R2 and macroscopic field non-uniformities, a group of 10 patients underwent ultra-high resolution 7T MRI...
May 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28447434/the-influence-of-different-muscle-mass-measurements-on-the-diagnosis-of-cancer-cachexia
#10
Susanne Blauwhoff-Buskermolen, Jacqueline A E Langius, Annemarie Becker, Henk M W Verheul, Marian A E de van der Schueren
BACKGROUND: Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored. METHODS: Prior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid-upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio-electrical impedance analysis (BIA)...
April 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28445975/functional-fgfr4-gly388arg-polymorphism-contributes-to-cancer-susceptibility-evidence-from-meta-analysis
#11
Si-Wei Xiong, Jianqun Ma, Fen Feng, Wen Fu, Shan-Rong Shu, Tianjiao Ma, Caixia Wu, Guo-Chang Liu, Jinhong Zhu
Fibroblast growth factor receptor 4 (FGFR4) is a member of receptor tyrosine kinase family. A functional Gly388Arg (rs351855 G>A) polymorphism in FGFR4 gene causes a glycine-to-arginine change at codon 388 within the transmembrane domain of the receptor. Although the FGFR4 rs351855 G>A polymorphism has been implicated in cancer development, its association with cancer risk remains controversial. Here, we have systematically analyzed the association between the rs351855 G>A polymorphism and cancer risk by performing a meta-analysis of 27 studies consisting of 8,682 cases and 9,731 controls...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445160/association-between-mmp2-1306-c-t-polymorphism-and-prostate-cancer-susceptibility-a-meta-analysis-based-on-3906-subjects
#12
Kaiping Zhang, Xianguo Chen, Jun Zhou, Cheng Yang, Meng Zhang, Min Chao, Li Zhang, Chaozhao Liang
Numerous investigations have addressed the correlation between MMP2-1306C/T polymorphism and prostate cancer (PCa) susceptibility. However, these conclusions were controversial. Thus, we conducted this current meta-analysis based on six studies from PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI) up to October 21st, 2016. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations. Additionally, different subgroup analyses and publication bias tests were performed...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28442297/vertebral-and-femoral-bone-mineral-density-and-bone-strength-in-prostate-cancer-patients-assessed-in-phantomless-pet-ct-examinations
#13
Benedikt J Schwaiger, David L Kopperdahl, Lorenzo Nardo, Luca Facchetti, Alexandra S Gersing, Jan Neumann, Kwang J Lee, Tony M Keaveny, Thomas M Link
PURPOSE: Bone fracture risk assessed ancillary to positron emission tomography with computed tomography co-registration (PET/CT) could provide substantial clinical value to oncology patients with elevated fracture risk without introducing additional radiation dose. The purpose of our study was to investigate the feasibility of obtaining valid measurements of bone mineral density (BMD) and finite element analysis-derived bone strength of the hip and spine using PET/CT examinations of prostate cancer patients by comparing against values obtained using routine multidetector-row computed tomography (MDCT) scans-as validated in previous studies-as a reference standard...
April 24, 2017: Bone
https://www.readbyqxmd.com/read/28415653/association-between-hif1a-rs11549465-polymorphism-and-risk-of-prostate-cancer-a-meta-analysis
#14
REVIEW
Xiao-Dong Li, Hao Zi, Cheng Fang, Xian-Tao Zeng
The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. Nevertheless, conflicting results have been obtained. Hence, we reevaluated this issue by means of this meta-analysis, with the purpose of providing more precise conclusion on this issue. The electronic databases of PubMed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) as well as other sources were searched for relevant reports concerning on the role of HIF1A rs11549465 polymorphism in the occurrence of prostate cancer...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402085/decision-aids-for-people-facing-health-treatment-or-screening-decisions
#15
REVIEW
Dawn Stacey, France Légaré, Krystina Lewis, Michael J Barry, Carol L Bennett, Karen B Eden, Margaret Holmes-Rovner, Hilary Llewellyn-Thomas, Anne Lyddiatt, Richard Thomson, Lyndal Trevena
BACKGROUND: Decision aids are interventions that support patients by making their decisions explicit, providing information about options and associated benefits/harms, and helping clarify congruence between decisions and personal values. OBJECTIVES: To assess the effects of decision aids in people facing treatment or screening decisions. SEARCH METHODS: Updated search (2012 to April 2015) in CENTRAL; MEDLINE; Embase; PsycINFO; and grey literature; includes CINAHL to September 2008...
April 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28352980/symptom-clusters-for-revising-scale-membership-in-the-analysis-of-prostate-cancer-patient-reported-outcome-measures-a-secondary-data-analysis-of-the-medical-research-council-rt01-trial-iscrtn47772397
#16
Agnieszka Lemanska, Tao Chen, David P Dearnaley, Rajesh Jena, Matthew R Sydes, Sara Faithfull
PURPOSE: To investigate the role of symptom clusters in the analysis and utilisation of patient reported outcome measures (PROMs) for data modelling and clinical practice. To compare symptom clusters with scales, and to explore their value in PROMs interpretation and symptom management. METHODS: A dataset called RT01 (ISCRTN47772397) of 843 prostate cancer patients was used. PROMs were reported with the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI)...
March 28, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28296724/meta-analysis-of-the-role-of-il-6-rs1800795-polymorphism-in-the-susceptibility-to-prostate-cancer-evidence-based-on-17-studies
#17
Tong-Zu Liu, Zhong-Qiang Guo, Ting Wang, Yue Cao, Di Huang, Xing-Huan Wang
Playing critical roles in immune responses, interleukin-6 (IL-6) has been proposed to be involved in the development of multiple cancers, including prostate cancer. The rs1800795 polymorphism in the promoter of the gene IL-6 can affect the transcription and expression of the gene, becoming a common target in association studies on tumors. We therefore carried out this meta-analysis to further discuss the relationship of this polymorphism with the risk of prostate cancer.Relevant publications were retrieved from the electronic databases...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28269511/enhanced-dual-stage-correlated-diffusion-imaging
#18
Farzad Khalvati, Junjie Zhang, Masoom A Haider, Alexander Wong
Prostate cancer is the most common form of cancer and third leading cause of cancer death in Canadian men. Multi-parametric magnetic resonance imaging (mpMRI) has become a powerful non-invasive diagnostic tool for the detection of prostate cancer. Among mpMRI imaging modalities, diffusion-weighed imaging has shown the most promising results in accurate detection of prostate cancer. Introduced recently, correlated diffusion imaging (CDI) is a new form of diffusion imaging which accounts for the joint correlation of diffusion signal attenuation across multiple gradient pulse strengths and timings to improve the separability of cancerous and healthy tissues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265239/determination-of-dosimetric-parameters-for-shielded-153-gd-source-in-prostate-cancer-brachytherapy
#19
Mahdi Ghorbani, Benyamin Khajetash, Najmeh Ghatei, Mohammad Mehrpouyan, Ali S Meigooni, Ramin Shahraini
BACKGROUND: Interstitial rotating shield brachytherapy (I-RSBT) is a recently developed method for treatment of prostate cancer. In the present study TG-43 dosimetric parameters of a (153)Gd source were obtained for use in I-RSBT. MATERIALS AND METHODS: A (153)Gd source located inside a needle including a Pt shield and an aluminum window was simulated using MCNPX Monte Carlo code. Dosimetric parameters of this source model, including air kerma strength, dose rate constant, radial dose function and 2D anisotropy function, with and without the shields were calculated according to the TG-43 report...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28227764/enhanced-dual-stage-correlated-diffusion-imaging
#20
Farzad Khalvati, Junjie Zhang, Masoom A Haider, Alexander Wong, Farzad Khalvati, Junjie Zhang, Masoom A Haider, Alexander Wong, Farzad Khalvati, Alexander Wong, Junjie Zhang, Masoom A Haider
Prostate cancer is the most common form of cancer and third leading cause of cancer death in Canadian men. Multi-parametric magnetic resonance imaging (mpMRI) has become a powerful non-invasive diagnostic tool for the detection of prostate cancer. Among mpMRI imaging modalities, diffusion-weighed imaging has shown the most promising results in accurate detection of prostate cancer. Introduced recently, correlated diffusion imaging (CDI) is a new form of diffusion imaging which accounts for the joint correlation of diffusion signal attenuation across multiple gradient pulse strengths and timings to improve the separability of cancerous and healthy tissues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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