keyword
MENU ▼
Read by QxMD icon Read
search

prostate cancer strength

keyword
https://www.readbyqxmd.com/read/29927081/overview-of-genetically-engineered-mouse-models-of-prostate-cancer-and-their-applications-in-drug-discovery
#1
Gianluca Civenni, Giuseppina M Carbone, Carlo V Catapano
Prostate cancer (PCa) is the most common malignant visceral neoplasm in males in Western countries. Despite progress made in the early treatment of localized malignancies, there remains a need for therapies effective against advanced forms of the disease. Genetically engineered mouse (GEM) models are valuable tools for addressing this issue, particularly in defining the cellular and molecular mechanisms responsible for tumor initiation and progression. While cell and tissue culture systems are important models for this purpose as well, they cannot recapitulate the complex interactions within heterotypic cells and the tumor microenvironment that are crucial in the initiation and progression of prostate tumors...
June 7, 2018: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/29908876/prostate-imaging-reporting-and-data-system-steering-committee-pi-rads-v2-status-update-and-future-directions
#2
Anwar R Padhani, Jeffrey Weinreb, Andrew B Rosenkrantsz, Geert Villeirs, Baris Turkbey, Jelle Barentsz
CONTEXT: The Prostate Imaging-Reporting and Data System (PI-RADS) v2 analysis system for multiparametric magnetic resonance imaging (mpMRI) detection of prostate cancer (PCa) is based on PI-RADS v1, accumulated scientific evidence, and expert consensus opinion. OBJECTIVE: To summarize the accuracy, strengths and weaknesses of PI-RADS v2, discuss pathway implications of its use and outline opportunities for improvements and future developments. EVIDENCE ACQUISITION: For this consensus expert opinion from the PI-RADS steering committee, clinical studies, systematic reviews, and professional guidelines for mpMRI PCa detection were evaluated...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29896435/the-value-of-contrast-enhanced-ultrasonography-combined-with-real-time-strain-elastography-in-the-early-diagnosis-of-prostate-cancer
#3
Ying Chang, Jingchun Yang, Hua Hong, Huijuan Ma, Xin Cui, Li Chen
To evaluate the performance of a combination of real-time strain elastography (RTSE) and contrast-enhanced transrectal ultrasound (CETRUS) for prostate cancer detection. Patients with serum prostate-specific antigen (PSA) levels of ≥4.0 ng/ml were prospectively enrolled between June 2014 and December 2016. 153 prostate nodules diagnosed by conventional ultrasound were prospectively enrolled and examined by CETRUS and RTSE before a biopsy. Multivariate logistic regression models were established for CETRUS, and CETRUS combined with RTSE to diagnose prostate malignancy...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29869394/optical-study-of-chemotherapy-efficiency-in-cancer-treatment-via-intracellular-structural-disorder-analysis-using-partial-wave-spectroscopy
#4
Huda M Almabadi, Prashanth K B Nagesh, Peeyush Sahay, Shiva Bhandari, Eugene C Eckstein, Meena Jaggi, Subhash C Chauhan, Murali M Yallappu, Prabhakar Pradhan
As cancer progresses, macromolecules, such as DNA, RNA, or lipids, inside cells undergo spatial structural rearrangements and alterations. Mesoscopic light transport based optical partial wave spectroscopy (PWS) was recently introduced to quantify changes in the nanoscale structural disorder in biological cells. The PWS measurement is performed using a parameter termed as 'disorder strength' (Ld ), which represents the degree of nanoscale structural disorder inside the cells. It was shown that cancerous cells have higher disorder strength than normal cells...
June 5, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29864112/hand-grip-strength-and-cognitive-function-among-elderly-cancer-survivors
#5
Lin Yang, Ai Koyanagi, Lee Smith, Liang Hu, Graham A Colditz, Adetunji T Toriola, Guillermo Felipe López Sánchez, Davy Vancampfort, Mark Hamer, Brendon Stubbs, Thomas Waldhör
BACKGROUND: We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: Data in two waves of NHANES (2011-2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value achieved using either hand. Two cognitive function tests were conducted among adults 60 years and older. The Animal Fluency Test (AFT) examines categorical verbal fluency (a component of executive function), and the Digital Symbol Substitution test (DSST) assesses processing speed, sustained attention, and working memory...
2018: PloS One
https://www.readbyqxmd.com/read/29772061/an-image-guided-radiotherapy-decision-support-framework-incorporating-a-bayesian-network-and-visualization-tool
#6
Catriona Hargrave, Timothy Deegan, Tomasz Bednarz, Michael Poulsen, Fiona Harden, Kerrie Mengersen
PURPOSE: To describe a Bayesian network (BN) and complementary visualization tool, that aim to support decision-making during online cone-beam computed tomography (CBCT)-based image guide radiotherapy (IGRT) for prostate cancer patients. METHODS: The BN was created to represent relationships between observed prostate, proximal seminal vesicle (PSV), bladder and rectum volume variations, an image feature alignment score (FASTV _ OAR ), delivered dose and treatment plan compliance (TPC)...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771950/biophotonic-detection-of-high-order-chromatin-alterations-in-field-carcinogenesis-predicts-risk-of-future-hepatocellular-carcinoma-a-pilot-study
#7
Richard Kalman, Andrew Stawarz, David Nunes, Di Zhang, Mart A Dela Cruz, Arpan Mohanty, Hariharan Subramanian, Vadim Backman, Hemant K Roy
PURPOSE: Hepatocellular carcinoma (HCC) results from chronic inflammation/cirrhosis. Unfortunately, despite use of radiological/serological screening techniques, HCC ranks as a leading cause of cancer deaths. Our group has used alterations in high order chromatin as a marker for field carcinogenesis and hence risk for a variety of cancers (including colon, lung, prostate, ovarian, esophageal). In this study we wanted to address whether these chromatin alterations occur in HCC and if it could be used for risk stratification...
2018: PloS One
https://www.readbyqxmd.com/read/29752463/personalization-of-prostate-cancer-therapy-through-phosphoproteomics
#8
REVIEW
Wei Yang, Michael R Freeman, Natasha Kyprianou
Castration-resistant prostate cancer (CRPC) remains incurable despite the approval of several new treatments. Identification of new biomarkers and therapeutic targets to enable personalization of CRPC therapy, with the aim of maximizing therapeutic responses and minimizing toxicity in patients, is urgently needed. Prostate cancer progression and therapeutic resistance are frequently driven by aberrantly activated kinase signalling pathways that are amenable to pharmacological inhibition. Personalized phosphoproteomics, which enables the analysis of signalling networks in individual tumours, is a promising approach to advance personalized therapy by discovering biomarkers of pathway activity and clinically actionable targets...
May 11, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29739772/associations-of-grip-strength-with-cardiovascular-respiratory-and-cancer-outcomes-and-all-cause-mortality-prospective-cohort-study-of-half-a-million-uk-biobank-participants
#9
Carlos A Celis-Morales, Paul Welsh, Donald M Lyall, Lewis Steell, Fanny Petermann, Jana Anderson, Stamatina Iliodromiti, Anne Sillars, Nicholas Graham, Daniel F Mackay, Jill P Pell, Jason M R Gill, Naveed Sattar, Stuart R Gray
OBJECTIVE: To investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score. DESIGN: Prospective population based study. SETTING: UK Biobank. PARTICIPANTS: 502 293 participants (54% women) aged 40-69 years. MAIN OUTCOME MEASURES: All cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate)...
May 8, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29712718/persisting-adverse-body-composition-changes-2-years-after-cessation-of-androgen-deprivation-therapy-for-localised-prostate-cancer
#10
Ada S Cheung, Alistair J Tinson, Stefan V Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associated with insulin resistance and decreased quality of life (QoL). Our objective was to assess whether adverse body composition changes improve after cessation of ADT. DESIGN: Prospective case-control study in a tertiary referral hospital. Thirty-four men newly commencing ADT (cases, median age: 67.6 years (interquartile range: 64.6-72...
July 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29700008/smoking-and-prostate-cancer-specific-mortality-after-diagnosis-in-a-large-prospective-cohort
#11
Ted Gansler, Roma Shah, Ying Wang, Victoria L Stevens, Baiyu Yang, Christina C Newton, Susan M Gapstur, Eric J Jacobs
Background: Prior studies of prostate cancer survivors suggest that smoking might be associated with higher prostate cancer-specific mortality (PCSM) after diagnosis with prostate cancer. However, most of these studies were small, and questions remain regarding this association's strength and whether it persists after adjustment for stage and Gleason score. Methods: This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study II Nutrition Cohort in 1992-1993 and June 2013...
June 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29684136/effects-of-a-group-mediated-exercise-and-dietary-intervention-in-the-treatment-of-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-results-from-the-idea-p-trial
#12
Brian C Focht, Alexander R Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M Fairman, Jennifer M Thomas-Ahner, Jackie Buell, J Paul Monk, Amir Mortazavi, Steven K Clinton
Background: Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome. Purpose: The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29670664/novel-model-for-cascading-failure-based-on-degree-strength-and-its-application-in-directed-gene-logic-networks
#13
Yulin Zhang, Maoxian Zhao, Jionglong Su, Xiao Lu, Kebo Lv
A novel model for cascading failures in a directed logic network based on the degree strength at a node was proposed. The definitions of in-degree and out-degree strength of a node were initially reconsidered, and the load at a nonisolated node was proposed as the ratio of in-degree strength to out-degree strength of the node. The cascading failure model based on degree strength was applied to the logic network for three types of cancer including adenocarcinoma of lung, prostate cancer, and colon cancer based on their gene expression profiles...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29614993/impact-of-resistance-training-on-body-composition-and-metabolic-syndrome-variables-during-androgen-deprivation-therapy-for-prostate-cancer-a-pilot-randomized-controlled-trial
#14
Jacqueline K Dawson, Tanya B Dorff, E Todd Schroeder, Christianne J Lane, Mitchell E Gross, Christina M Dieli-Conwright
BACKGROUND: Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS). Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS. This pilot trial investigated 12 weeks of resistance training on body composition and MetS changes in prostate cancer patients on ADT...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29611275/clinical-and-prognostic-significance-of-changes-in-haemoglobin-concentration-during-1-year-of-androgen-deprivation-therapy-for-hormone-na%C3%A3-ve-bone-metastatic-prostate-cancer
#15
Maria Ebbinge, Anders Berglund, Eberhard Varenhorst, Per Olov Hedlund, Gabriel Sandblom
OBJECTIVE: To estimate the strength of change in haemoglobin (Hb) concentrations during 1 year of androgen-deprivation therapy (ADT) as a predictor of survival in hormone-naïve patients with bone-metastatic (Stage M1b) prostate cancer. PATIENTS AND METHODS: The patients included in this study were taken from the randomised trial (number 5) carried out by the Scandinavian Prostate Cancer Group (SPCG), comparing parenteral oestrogen with total androgen blockade (TAB) in hormone-naïve M1b prostate cancer...
April 2, 2018: BJU International
https://www.readbyqxmd.com/read/29610962/are-clinical-guidelines-designed-according-to-guidelines-cross-sectional-assessment-of-quality-and-transparency-of-clinical-guidelines-in-urology
#16
Roderick C N van den Bergh, Piet Ost, Christian Surcel, Massimo Valerio, Jurgen J Fütterer, Giorgio Gandaglia, Prasanna Sooriakumaran, Derya Tilki, Igor Tsaur, Guillaume Ploussard
PURPOSE: Guidelines and recommendations become increasingly important in clinical urologic practice. This study aims to inform clinicians using guidelines on how to evaluate the quality of the methodology and transparency of these documents. METHODS: The guidelines on management of castration-resistant prostate cancer of the American Urology Association, European Association of Urology, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, European Society of Medical Oncology were reviewed using the AGREE-II tool (Appraisal of Guidelines for Research and Evaluation)...
April 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#17
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS AND METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions (table 1 in supplementary unabridged guideline, http://jurology...
March 28, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29569731/exercise-and-prostate-cancer-from-basic-science-to-clinical-applications
#18
REVIEW
Christian Campos, Paula Sotomayor, Daniel Jerez, Javier González, Camila B Schmidt, Katharina Schmidt, Winfried Banzer, Alejandro S Godoy
Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment...
June 2018: Prostate
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#19
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29561434/meta-analysis-of-cdkn2a-methylation-to-find-its-role-in-prostate-cancer-development-and-progression-and-also-to-find-the-effect-of-cdkn2a-expression-on-disease-free-survival-prisma
#20
Zipei Cao, Lijuan Wei, Weizhi Zhu, Xuping Yao
BACKGROUND: Reduction of cyclin-dependent kinase inhibitor 2A (CDKN2A) (p16 and p14) expression through DNA methylation has been reported in prostate cancer (PCa). This meta-analysis was conducted to assess the difference of p16 and p14 methylation between PCa and different histological types of nonmalignant controls and the correlation of p16 or p14 methylation with clinicopathological features of PCa. METHODS: According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, articles were searched in PubMed, Embase, EBSCO, Wanfang, and CNKI databases...
March 2018: Medicine (Baltimore)
keyword
keyword
104437
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"