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https://www.readbyqxmd.com/read/29036016/exercise-preserves-physical-function-in-prostate-cancer-patients-with-bone-metastases
#1
Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann, James Denham, Michael Baker, Robert U Newton
PURPOSE: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. METHODS: Between 2012 and 2015, 57 prostate cancer patients (70.0±8.4 years; BMI 28.7±4.0 kg/m) with bone metastases (pelvis 75...
October 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29030906/effects-of-interruptions-of-external-beam-radiation-therapy-on-outcomes-in-patients-with-prostate-cancer
#2
Yanqun Dong, Nicholas G Zaorsky, Tianyu Li, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Yt Chen, Robert G Uzzo, Mark A Hallman, Eric M Horwitz
INTRODUCTION: To evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer (PCa). METHODS: We included men with localized PCa treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) of escalated dose (≥74 Gy in 1.8 or 2 Gy fractions) between 1992 and 2013 at an NCI-designated cancer centre. Men receiving androgen deprivation therapy were excluded. The non-treatment day ratio (NTDR) was defined as the number of non-treatment days divided by the total elapsed days of therapy...
October 13, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28974267/efficacy-of-a-multi-component-exercise-programme-and-nutritional-supplementation-on-musculoskeletal-health-in-men-treated-with-androgen-deprivation-therapy-for-prostate-cancer-impact-study-protocol-of-a-randomised-controlled-trial
#3
Patrick J Owen, Robin M Daly, Patricia M Livingston, Niamh L Mundell, Jack Dalla Via, Jeremy L Millar, Steve F Fraser
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is a systemic treatment shown to increase survival in selected patients with prostate cancer. The use of ADT continues to increase for all stages and grades of prostate cancer despite known treatment-induced adverse effects. The primary aim of this study is to examine the efficacy of a targeted, multi-component resistance and impact-loading exercise programme together with a daily protein-, calcium- and vitamin D-enriched supplement on bone health in men treated with ADT for prostate cancer...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28969404/effect-of-green-tea-catechins-in-patients-with-high-grade-prostatic-intraepithelial-neoplasia-results-of-a-short-term-double-blind-placebo-controlled-phase-ii-clinical-trial
#4
Salvatore Micali, Angelo Territo, Giacomo Maria Pirola, Nancy Ferrari, Maria Chiara Sighinolfi, Eugenio Martorana, Michele Navarra, Giampaolo Bianchi
BACKGROUND AND STUDY OBJECTIVE: Several studies suggest a protective role of green tea catechins against prostate cancer (PCa). In order to evaluate the efficacy of green tea catechins for chemoprevention of PCa in patients with high-grade prostate intraepithelial neoplasia (HG-PIN) we performed a phase II clinical trial. METHODS: Sixty volunteers with HG-PIN were enrolled to carry out a double-blind randomized placebo-controlled phase II clinical trial. Treated group took daily 600 mg of green tea catechins (Categ Plus®) for 1 year...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28965787/reporting-erectile-function-outcomes-after-radiation-therapy-for-prostate-cancer-challenges-in-data-interpretation
#5
Ruud C Wortel, Luca Incrocci, John P Mulhall
BACKGROUND: Choice of prostate cancer treatment is frequently influenced by the expected chance of treatment-induced side effects such as erectile dysfunction (ED). However, great discrepancy in cited ED rates exists in the contemporary radiation therapy literature. AIM: To analyze the reported ED rates and cause of discrepancies and explore the strengths and limitations in the literature on radiation-induced ED. METHODS: We performed a PubMed literature search and reviewed the literature on ED rates associated with external-beam radiotherapy and brachytherapy from the past 10 years...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28917937/pyrazole-based-compounds-in-chitosan-liposomal-emulsion-for-antimicrobial-cotton-fabrics
#6
Ahmed Nada, Marwa Al-Moghazy, Ahmed A F Soliman, Gehan M T Rashwan, Taghreed Hosny Ahmed Eldawy, Ashraf Abd Elhakim Hassan, Galal Hosni Sayed
The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-Phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] and 1H- pyrazole-3 (1), 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (2) were synthesized, characterized and encapsulated into liposomal chitosan emulsions for textile finishing. The chemical modifications of cotton fabrics were demonstrated by infrared analysis...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28915684/lack-of-association-between-nat2-polymorphism-and-prostate-cancer-risk-a-meta-analysis-and-trial-sequential-analysis
#7
Feng Wang, Zhiqiang Qin, Shuhui Si, Jingyuan Tang, Lingyan Xu, Haoxiang Xu, Ran Li, Peng Han, Haiwei Yang
Previous studies have investigated the association between NAT2 polymorphism and the risk of prostate cancer (PCa). However, the findings from these studies remained inconsistent. Hence, we performed a meta-analysis to provide a more reliable conclusion about such associations. In the present meta-analysis, 13 independent case-control studies were included with a total of 14,469 PCa patients and 10,689 controls. All relevant studies published were searched in the databates PubMed, EMBASE, and Web of Science, till March 1st, 2017...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915683/association-between-8q24-rs6983267-polymorphism-and-cancer-susceptibility-a-meta-analysis-involving-170-737-subjects
#8
Man Zhu, Xue Wen, Xuefang Liu, Yingchao Wang, Chunzi Liang, Jiancheng Tu
Published data on the association between 8q24 rs6983267 polymorphism and cancer risk are inconsistent. Thus, we conducted a meta-analysis to evaluate the relationship between rs6983267 polymorphism and cancer risk. We searched on PubMed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) up to November 1, 2016 for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of this association. We included 78 case-control studies with a total of 73,996 cases and 96,741 controls in this meta-analysis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874884/quality-by-design-applied-liquid-chromatography-tandem-mass-spectrometry-determination-of-enzalutamide-anti-prostate-cancer-therapy-drug-in-spiked-plasma-samples
#9
Ask Sankar, Shanmugasundaram Palani, Ravichandiran Velayudham
This research article presents the Quality by Design (QbD)-finalised conditions for a method that uses liquid chromatography-tandem mass spectrometry for the determination of concentration of enzalutamide (ENZ), an atypical anticancer drug, in a drug formulation and in spiked plasma samples. Critical process attributes (CPA) considered to be the influential parameters in separation, identification, and quantification processes by ultrahigh-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (UHPLC-ESI-MS/MS) were organic content, buffer strength, pH modifier, flow rate, spray voltage, sheath gas, and auxiliary gas that alter critical analytical attributes, such as retention time (R1) and area (R2)...
2017: Analytical Chemistry Insights
https://www.readbyqxmd.com/read/28874332/the-relationship-between-incontinence-and-erectile-dysfunction-after-robotic-prostatectomy-are-they-mutually-exclusive
#10
Savas T Tsikis, Charles U Nottingham, Sarah F Faris
BACKGROUND: Urinary incontinence (UI) and erectile dysfunction (ED) remain the most common long-term complications of prostatectomy, with a significant impact on sexual health and quality of life. AIMS: To determine the relation between UI and moderate to severe ED and the risk factors for UI in patients undergoing robotic-assisted laparoscopic prostatectomy. METHODS: Patients in our institutional database who underwent robotic-assisted laparoscopic prostatectomy for prostate cancer (2006-2013) and who completed the University of California-Los Angeles Prostate Cancer Index and the Sexual Health Inventory for Men (SHIM) surveys at 12 months after prostatectomy were eligible for inclusion...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28872752/time-on-androgen-deprivation-therapy-and-adaptations-to-exercise-secondary-analysis-from-a-12-month-randomized-controlled-trial-in-men-with-prostate-cancer
#11
Dennis R Taaffe, Laurien M Buffart, Robert U Newton, Nigel Spry, James Denham, David Joseph, David Lamb, Suzanne K Chambers, Daniel A Galvão
OBJECTIVES: To explore if duration of prior exposure to androgen deprivation therapy (ADT) in men with prostate cancer (PCa) undertaking a yearlong exercise program moderates the exercise response on body composition and muscle performance. In addition, we explored the moderator effect of baseline testosterone, time since ADT, and baseline value of the outcome. PATIENTS AND METHODS: In a multicenter randomized controlled trial, 100 patients previously treated for either 6 months (short-term) or 18 months (long-term) ADT in combination with radiotherapy as part of the TROG 03...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28859870/the-natural-history-of-erectile-dysfunction-after-prostatic-radiotherapy-a-systematic-review-and-meta-analysis
#12
REVIEW
Thomas W Gaither, Mohannad A Awad, E Charles Osterberg, Gregory P Murphy, Isabel E Allen, Albert Chang, Raymond C Rosen, Benjamin N Breyer
BACKGROUND: Erectile dysfunction (ED) after treatment for prostate cancer with radiotherapy (RT) is well known, and pooled estimates of ED after RT will provide more accurate patient education. AIM: To systematically evaluate the natural history of ED in men with previous erectile function after prostate RT and to determine clinical factors associated with ED. METHODS: We performed a review of the PubMed and Medline, Embase, Cochrane Library, and Web of Science databases in April 2016 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement...
September 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28858475/dysprosium-modified-tobacco-mosaic-virus-nanoparticles-for-ultra-high-field-magnetic-resonance-and-near-infrared-fluorescence-imaging-of-prostate-cancer
#13
He Hu, Yifan Zhang, Sourabh Shukla, Yuning Gu, Xin Yu, Nicole F Steinmetz
The increasing prevalence of ultra-high-field magnetic resonance imaging (UHFMRI) in biomedical research and clinical settings will improve the resolution and diagnostic accuracy of MRI scans. However, better contrast agents are needed to achieve a satisfactory signal-to-noise ratio. Here, we report the synthesis of a bimodal contrast agent prepared by loading the internal cavity of tobacco mosaic virus (TMV) nanoparticles with a dysprosium (Dy(3+)) complex and the near-infrared fluorescence (NIRF) dye Cy7...
September 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28843375/mr-opera-a-multicenter-multivendor-validation-of-magnetic-resonance-imaging-only-prostate-treatment-planning-using-synthetic-computed-tomography-images
#14
Emilia Persson, Christian Gustafsson, Fredrik Nordström, Maja Sohlin, Adalsteinn Gunnlaugsson, Karin Petruson, Niina Rintelä, Kristoffer Hed, Lennart Blomqvist, Björn Zackrisson, Tufve Nyholm, Lars E Olsson, Carl Siversson, Joakim Jonsson
PURPOSE: To validate the dosimetric accuracy and clinical robustness of a commercially available software for magnetic resonance (MR) to synthetic computed tomography (sCT) conversion, in an MR imaging-only workflow for 170 prostate cancer patients. METHODS AND MATERIALS: The 4 participating centers had MriPlanner (Spectronic Medical), an atlas-based sCT generation software, installed as a cloud-based service. A T2-weighted MR sequence, covering the body contour, was added to the clinical protocol...
June 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28811991/systematic-review-of-the-outcomes-of-surgical-treatment-of-prostate-metastases-to-the-spine
#15
REVIEW
Michelle J Clarke, Camilo A Molina, Daryl R Fourney, Charles G Fisher, Ziya L Gokaslan, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Shreyaskumar R Patel, Y Raja Rampersaud, Jeremy Reynolds, Dean Chou, Chetan Bettegowda, Ehud Mendel, Michael H Weber, Daniel M Sciubba
STUDY DESIGN: Systematic review. OBJECTIVE: Surgical decompression and reconstruction of symptomatic spinal metastases has improved the quality of life in cancer patients. However, most data has been collected on cohorts of patients with mixed tumor histopathology. We systematically reviewed the literature for prognostic factors specific to the surgical treatment of prostate metastases to the spine. METHODS: A systemic review of the literature was conducted to answer the following questions: Question 1...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28774788/does-psychological-resilience-buffer-against-the-link-between-the-5-httlpr-polymorphism-and-depression-following-stress
#16
Christopher F Sharpley, David R H Christie, Vicki Bitsika, Nicholas M Andronicos, Linda L Agnew, Mary E McMillan
The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression...
July 31, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28738774/advanced-methods-for-analysis-of-testosterone
#17
Livia Alexandra Gugoasa, Raluca Ioana Stefan-van Staden
Testosterone is the principal endogenous androgenic-anabolic steroid in humans. The levels of testosterone in the human body are correlated with many hormonal disorders (hypogonadism, impotence, etc) mostly in men, and with many types of diseases such as: prostate cancer, metabolic syndrome, obesity, cardiovascular diseases and so on. Testosterone is extensively used among sportsmen willing to increase strength, aggressiveness, and recovery; making it the most commonly reported substance in steroid abuse. Fast, easy and cheap methods for the evaluation of testosterone are extremely needed in clinics and hospitals...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28731882/the-effect-on-bone-outcomes-of-home-based-exercise-intervention-for-prostate-cancer-survivors-receiving-androgen-deprivation-therapy-a-pilot-randomized-controlled-trial
#18
Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Young Deuk Choi, Eunju Choi, Youngkyu Song, Hosook Song
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25)...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28725242/focal-application-of-low-dose-rate-brachytherapy-for-prostate-cancer-a-pilot-study
#19
S Sara Mahdavi, Ingrid T Spadinger, Septimiu E Salcudean, Piotr Kozlowski, Silvia D Chang, Tony Ng, Julio Lobo, Guy Nir, Hamid Moradi, Michael Peacock, W James Morris
PURPOSE: To evaluate the feasibility and to report the early outcomes of focal treatment of prostate cancer using low-dose-rate brachytherapy (LDR-PB). MATERIAL AND METHODS: Seventeen patients were screened with multi-parametric magnetic resonance imaging (mpMRI), 14 of whom proceeded to receive trans-perineal template mapping biopsy (TTMB). Focal LDR-PB was performed on five eligible patients using dual air kerma strength treatment plans based on planning target volumes derived from cancer locations and determined by TTMB...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28724196/a-local-agreement-pattern-measure-based-on-hazard-functions-for-survival-outcomes
#20
Tian Dai, Ying Guo, Limin Peng, Amita K Manatunga
Assessing agreement is often of interest in biomedical and clinical research when measurements are obtained on the same subjects by different raters or methods. Most classical agreement methods have been focused on global summary statistics, which cannot be used to describe various local agreement patterns. The objective of this work is to study the local agreement pattern between two continuous measurements subject to censoring. In this article, we propose a new agreement measure based on bivariate hazard functions to characterize the local agreement pattern between two correlated survival outcomes...
July 19, 2017: Biometrics
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