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https://www.readbyqxmd.com/read/29139310/pudendal-nerve-injury-impairs-anorectal-function-and-health-related-quality-of-life-measures-%C3%A2-2-years-after-3d-conformal-radiotherapy-for-prostate-cancer
#1
Eng Eric Yeoh, Rochelle Botten, Addolorata Di Matteo, Marcus Tippett, Jonathon Hutton, Robert Fraser, Phillip G Dinning, David Wattchow
PURPOSE: To compare GI symptoms, measures of generic and disease specific health related quality of life (HRQoL), anorectal and pudendal nerve function and anal sphincter morphology between (i) patients ≥2 years after 3D conformal radiotherapy (3D-CRT)±high dose rate (HDR) brachytherapy for carcinoma of the prostate and aged matched patients before radiotherapy and (ii) symptomatic and asymptomatic patients ≥2 years after 3D-CRT ± HDR brachytherapy. MATERIAL AND METHODS: Methodology included: (i) modified LENT-SOMA scales for GI symptoms, (ii) EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires for generic and disease specific HRQoL, (iii) anorectal manometry and terminal motor latency for anorectal and pudendal nerve function and (iv) endorectal ultrasound for anal sphincter morphology...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29138865/silencing-of-vacuolar-atpase-c%C3%A2-subunit-atp6v0c-inhibits-the-invasion-of-prostate-cancer-cells-through-a-lass2-tmsg1-independent-manner
#2
Pengcheng Zou, Yifeng Yang, Xiaoyan Xu, Beiying Liu, Fang Mei, Jiangfeng You, Qichen Liu, Fei Pei
Vacuolar ATPase (V-ATPase), widespread in eukaryotic cells, is extensively expressed in many highly metastatic tumors, of which the V-ATPase c subunit ATP6V0C is particularly associated with the invasion and metastasis of cancer. ATP6V0C was directly found to interact with LASS2/TMSG1 which is a new tumor metastasis inhibitory gene identified by our laboratory in 1999. In order to study the role of ATP6V0C, we generated small interference RNA (siRNA) targeting ATP6V0C and investigated its function on the invasion of human prostate cancer cell line PC-3M-1E8 with high metastatic potential and its interplay with LASS2/TMSG1...
November 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29138842/placenta-specific-protein-1-promotes-cell-proliferation-and-invasion-in-non-small-cell-lung-cancer
#3
Li Yang, Tian-Qi Zha, Xiang He, Liang Chen, Quan Zhu, Wei-Bing Wu, Feng-Qi Nie, Qian Wang, Chong-Shuang Zang, Mei-Ling Zhang, Jing He, Wei Li, Wen Jiang, Kai-Hua Lu
Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small cell lung cancer (NSCLC) development and progression are still unknown...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29137877/immune-analysis-of-radium-223-in-patients-with-metastatic-prostate-cancer
#4
Joseph W Kim, Min Sun Shin, Youna Kang, Insoo Kang, Daniel P Petrylak
BACKGROUND: Radium223 (Ra223) delivers high-energy radiation to osteoblastic metastasis of prostate cancer, resulting in irreparable double-stranded DNA damage. The effects of Ra223 on CD8+ T cell subsets in patients with prostate cancer is unknown. PATIENTS AND METHODS: Fifteen men with metastatic prostate cancer with clinical indication for Ra223 without any autoimmune or immune deficiency conditions were enrolled. Patients received a course of Ra223 50 kBq/kg...
October 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29137275/vinculin-and-filamin-c-are-two-potential-prognostic-biomarkers-and-therapeutic-targets-for-prostate-cancer-cell-migration
#5
Jianzhong Ai, Tao Jin, Lu Yang, Qiang Wei, Yang Yang, Hong Li, Ye Zhu
Prostate cancer (PCa) is one of the most common diseases for male population, and the effective treatment for metastatic castration-resistant PCa is still lacking. To unravel the underlying mechanism of PCa cell migration, we plan to analyze the related crucial proteins and their roles. In our study, we firstly identify the differentially expressed proteins using quantitative proteomics, and confirm their mRNA expression using quantitative polymerase chain reaction (qPCR). The alterations of these proteins at DNA and mRNA levels are obtained from cBioPortal database...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137265/c-met-creb1-and-egfr-are-involved-in-mir-493-5p-inhibition-of-emt-via-akt-gsk-3%C3%AE-snail-signaling-in-prostate-cancer
#6
Song Wang, Xiao Wang, Jiangfeng Li, Shuai Meng, Zhen Liang, Xin Xu, Yi Zhu, Shiqi Li, Jian Wu, Mingjie Xu, Alin Ji, Yiwei Lin, Ben Liu, Xiangyi Zheng, Bo Xie, Liping Xie
miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of miR-493-5p expression pattern and its function in prostate cancer remains to be elucidated. Here, we illustrate that miR-493-5p is frequently downregulated in prostate cancer, at least partially due to altered DNA methylation. miR-493-5p functions as a tumor suppressor in prostate cancer cells. c-Met, CREB1 and EGFR are downstream target genes of miR-493-5p. miR-493-5p inhibits EMT via AKT/GSK-3β/Snail signaling in prostate cancer...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136770/magnesium-valproate-ameliorates-type-1-diabetes-and-cardiomyopathy-in-diabetic-rats-through-estrogen-receptors
#7
Samir Rabadiya, Shradhha Bhadada, Ashvin Dudhrejiya, Devendra Vaishnav, Bhoomika Patel
Estrogen is known to exhibit cardioprotective and antihyperlipidemic action. Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues. No pharmacological evaluations for magnesium valproate (MgV) so far have been done for diabetic cadio-lipidemic complications. Based on the above context, current study was undertaken to evaluate the therapeutic effectiveness of MgV in cardiac complications associated with type-1 diabetes mellitus in rats wherein diabetes was induced by single tail vein injection of streptozotocin (STZ, 45mg/kg, IV) in female Sprague Dawley rats and treatment of MgV (210mg/kg, PO) was given for eight weeks to diabetic animals, after which, various biochemical and cardiac biomarkers, hypertrophic, hemodynamic and histological parameters along with immunohistochemistry of ERs in the left ventricle (LV) were estimated...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136406/the-interaction-between-androgen-receptor-and-semenogelin-i-a-synthetic-lxxll-peptide-antagonist-inhibits-the-growth-of-prostate-cancer-cells
#8
Peng Li, Jinbo Chen, Eiji Kashiwagi, Taichi Mizushima, Bin Han, Satoshi Inoue, Hiroki Ide, Koji Izumi, Hiroshi Miyamoto
BACKGROUND: We previously demonstrated that a seminal plasma protein, semenogelin I (SgI), functioned as an androgen receptor (AR) coactivator. Meanwhile, several short sequence motifs in AR coregulators, such as LxxLL (L=leucine), have been shown to mediate specific interactions with AR. METHODS: We investigated the role of the LxxLL motif within SgI in the interactions with AR and cell growth in prostate cancer lines in vitro. RESULTS: A full-length SgI with mutations in the motif (i...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29135694/impact-of-prostate-cancer-and-its-treatment-on-the-outcomes-of-ileal-pouch-anal-anastomosis
#9
Lei Lian, Jean Ashburn, Erick M Remer, Feza H Remzi, Manoj Monga, Bo Shen
BACKGROUND: There are scant published data in the impact of prostate cancer and its treatment on functional outcomes and quality of life (QOL) in patients with ileal pouch-anal anastomosis (IPAA). The aim of the study was to evaluate the influence of prostate cancer and its treatment on functional outcomes and QOL in patients with IPAA. METHODS: Patients with IPAA with prostate cancer were compared to age and pouch duration-matched controls without prostate cancer in a 1:2 ratio...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29134229/decursin-and-decursinol-angelate-molecular-mechanism-and-therapeutic-potential-in-inflammatory-diseases
#10
REVIEW
Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Lee
Epidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots of Angelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase C...
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29131367/influence-of-the-neural-microenvironment-on-prostate-cancer
#11
Christian Coarfa, Diego Florentin, NagiReddy Putluri, Yi Ding, Jason Au, Dandan He, Ahmed Ragheb, Anna Frolov, George Michailidis, MinJae Lee, Dov Kadmon, Brian Miles, Christopher Smith, Michael Ittmann, David Rowley, Arun Sreekumar, Chad J Creighton, Gustavo Ayala
BACKGROUND: Nerves are key factors in prostate cancer (PCa), but the functional role of innervation in prostate cancer is poorly understood. PCa induced neurogenesis and perineural invasion (PNI), are associated with aggressive disease. METHOD: We denervated rodent prostates chemically and physically, before orthotopically implanting cancer cells. We also performed a human neoadjuvant clinical trial using botulinum toxin type A (Botox) and saline in the same patient, before prostatectomy...
November 13, 2017: Prostate
https://www.readbyqxmd.com/read/29131323/validity-and-usefulness-of-a-single-item-measure-of-patient-reported-bother-from-side-effects-of-cancer-therapy
#12
Timothy P Pearman, Jennifer L Beaumont, Daniel Mroczek, Mary O'Connor, David Cella
BACKGROUND: The improving efficacy of cancer treatment has resulted in an increasing array of treatment-related symptoms and associated burdens imposed on individuals undergoing aggressive treatment of their disease. Often, clinical trials compare therapies that have different types, and severities, of adverse effects. Whether rated by clinicians or patients themselves, it can be difficult to know which side effect profile is more disruptive or bothersome to patients. A simple summary index of bother can help to adjudicate the variability in adverse effects across treatments being compared with each other...
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29129780/prior-radiation-therapy-decreases-time-to-idiopathic-erosion-of-artificial-urinary-sphincter-a-multi-institutional-analysis
#13
Melissa R Kaufman, Douglas F Milam, Niels V Johnsen, Mario A Cleves, Joshua A Broghammer, William O Brant, LeRoy A Jones, Jeffrey D Brady, Martin S Gross, Gerard D Henry
PURPOSE: Substantial controversy and conflicting data exist regarding device survival of the artificial urinary sphincter (AUS) in patients with prior radiation therapy. Herein we present data from a multi-institutional analysis examining the effect of prior radiation for prostate cancer on device survival. MATERIALS AND METHODS: A database was compiled of AUS cuff erosion patients including demographic and comorbid patient characteristics, functional analyses, and interventions...
November 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29129687/coatomer-subunit-beta-2-copb2-identified-by-label-free-quantitative-proteomics-regulates-cell-proliferation-and-apoptosis-in-human-prostate-carcinoma-cells
#14
Yuanyuan Mi, Chuanyu Sun, Bingbing Wei, Feiyu Sun, Yijun Guo, Qingfeng Hu, Weihong Ding, Lijie Zhu, Guowei Xia
Label-free quantitative proteomics has broad applications in the identification of differentially expressed proteins. Here, we applied this method to identify differentially expressed proteins (such as coatomer subunit beta 2 [COPB2]) and evaluated the functions and molecular mechanisms of these proteins in prostate cancer (PCA) cell proliferation. Proteins extracted from surgically resected PCA tissues and adjacent tissues of 3 patients were analyzed by label-free quantitative proteomics. The target protein was confirmed by bioinformatics and GEO dataset analyses...
November 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29128526/functional-analysis-of-cullin-3-e3-ligases-in-tumorigenesis
#15
REVIEW
Ji Cheng, Jianping Guo, Zhiwei Wang, Brian J North, Kaixiong Tao, Xiangpeng Dai, Wenyi Wei
Cullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various physiological and pathological processes, including neoplastic events. The substrate adaptors of CRL3 typically contain a BTB domain that mediates the interaction between Cullin 3 and target substrates to promote their ubiquitination and subsequent degradation. The biological implications of CRL3 adaptor proteins have been well described where they have been found to play a role as either an oncogene, tumor suppressor, or can mediate either of these effects in a context-dependent manner...
November 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29128271/predictors-of-patient-and-partner-satisfaction-following-radical-prostatectomy
#16
REVIEW
Cailey Guercio, Akanksha Mehta
INTRODUCTION: The diagnosis and treatment of prostate cancer adversely affects the physical and emotional well-being of patients and partners and has been associated with sexual dysfunction in patients and their intimate partners. AIM: To identify predictors of sexual satisfaction in prostate cancer survivors and their partners based on a review of the current literature. METHODS: We performed a comprehensive review of the PubMed database from January 2000 to May 2017 focused on the (i) prevalence of patient and partner sexual dysfunction related to radical prostatectomy, (ii) differences in patient and partner perspectives of sexual function and dysfunction, and (iii) predictors of patient and partner sexual satisfaction after radical prostatectomy...
November 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29127529/the-impact-of-prostate-cancer-diagnosis-and-treatment-decision-making-on-health-related-quality-of-life-before-treatment-onset
#17
Maarten Cuypers, Romy E D Lamers, Erik B Cornel, Lonneke V van de Poll-Franse, Marieke de Vries, Paul J M Kil
OBJECTIVE: The objective of this study is to test if patients' health-related quality of life (HRQoL) declines after prostate biopsy to detect Pca, and after subsequent treatment decision-making in case Pca is confirmed, and to test whether personality state and traits are associated with these potential changes in HRQoL. METHODS: Patients who were scheduled for prostate biopsy to detect Pca (N = 377) filled out a baseline questionnaire about HRQoL (EORTC QLQ-C30 and PR25), "big five" personality traits (BFI-10), optimism (LOT-r), and self-efficacy (Decision Self-efficacy Scale) (t0)...
November 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29127215/in-patients-with-localised-prostate-cancer-active-surveillance-is-associated-with-better-sexual-function-urinary-symptoms-and-bowel-symptoms
#18
Roderick C N van den Bergh, Marie-Anne van Stam
No abstract text is available yet for this article.
November 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/29126844/prospective-outcome-analysis-of-the-safety-and-efficacy-of-partial-and-complete-cryoablation-in-organ-confined-prostate-cancer
#19
A Barqawi, E Huebner, K Krughoff, C I O'Donnell
OBJECTIVES: To determine the rate of complications and change in IPSS and SHIM scores following cryotherapy treatment of low and intermediate risk prostate cancer. Secondary endpoint was change in PSA post-cryotherapy and biopsy-proven recurrence. METHODS: Enrollment occurred from 2007-2015 to assess long-term complications of cryotherapy. A prostate biopsy was performed at one year or in the event of biochemical failure. Subjects were staged and graded by standard 12-14 core TRUS biopsy...
November 7, 2017: Urology
https://www.readbyqxmd.com/read/29124512/synthesis-and-antiproliferative-and-apoptosis-inducing-activity-of-novel-3-substituted-3-hydroxy-2-oxindole-compounds
#20
Mona Nazemi Moghaddam, Razieh Jalal, Zohreh Zeraatkar
Anticancer role of oxindole compounds is well documented. Here, we synthesized new derivatives of 3-hydroxy-2-oxindole functionalized at position 3 (1a-f) which are expected to have antiproliferative activity in cancer cells. Human prostate cancer cell line (DU145) was treated with the synthesized derivatives at 40-μM concentration for 24, 48, and 72 h. Compounds 1-ethyl-3-hydroxy-1,1',3,3'-tetrahydro-2H,2'H-3,3'-biindole-2,2'-dione (1d), 5-bromo-1-ethyl-3-hydroxy-1,1',3,3'-2H,2'H-3,3'-biindole-2,2'-dione (1e), and 5-chloro-1-ethyl-3-hydroxy-1,1',3,3'-tetrahydro-2H,2'H-3,3'-biindole-2,2'-dione (1f) were found to significantly reduce DU145 cell viability at 48 and 72 h whereas no significant changes were observed up to 24 h...
November 9, 2017: In Vitro Cellular & Developmental Biology. Animal
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