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https://www.readbyqxmd.com/read/27913018/potential-impact-of-flowback-water-from-hydraulic-fracturing-on-agricultural-soil-quality-metal-metalloid-bioaccessibility-microtox-bioassay-and-enzyme-activities
#1
Season S Chen, Yuqing Sun, Daniel C W Tsang, Nigel J D Graham, Yong Sik Ok, Yujie Feng, Xiang-Dong Li
Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives. This study investigated the potential impact of flowback water on four representative soils from shale gas regions in Northeast China using synthetic flowback solutions. The compositions of the solutions were representative of flowback water arising at different stages after fracturing well establishment...
November 29, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27912996/alternative-exercise-traditions-in-cancer-rehabilitation
#2
REVIEW
Kathryn J Ruddy, Daniela L Stan, Anjali Bhagra, Mary Jurisson, Andrea L Cheville
Alternative exercise traditions (AETs) such as Pilates, yoga, Tai Chi Chuan, Qigong, and various forms of dance offer the potential to improve diverse outcomes among cancer survivors by reducing adverse symptoms and mood disorders, and by enhancing function. Additionally AETs have emerged as a potential means to address deficits in current disease-focused care delivery models which are marked by prevalent under-treatment of symptoms and physical impairments. Relative to therapeutic exercise in allopathic models, many AETs are comparatively affordable and accessible...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27911828/evaluating-the-evaluation-of-cancer-driver-genes
#3
Collin J Tokheim, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Rachel Karchin
Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have been developed to identify driver genes, but evaluation of the performance of these methods is hindered by the lack of a gold standard, that is, bona fide driver gene mutations. Here, we establish an evaluation framework that can be applied to driver gene prediction methods. We used this framework to compare the performance of eight such methods. One of these methods, described here, incorporated a machine-learning-based ratiometric approach...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909034/advance-care-planning-in-patients-with-incurable-cancer-study-protocol-for-a-randomised-controlled-trial
#4
Stephanie Johnson, Josephine Clayton, Phyllis N Butow, William Silvester, Karen Detering, Jane Hall, Belinda E Kiely, Jonathon Cebon, Stephen Clarke, Melanie L Bell, Martin Stockler, Phillip Beale, Martin H N Tattersall
INTRODUCTION: There is limited evidence documenting the effectiveness of Advance Care Planning (ACP) in cancer care. The present randomised trial is designed to evaluate whether the administration of formal ACP improves compliance with patients' end-of-life (EOL) wishes and patient and family satisfaction with care. METHODS AND ANALYSIS: A randomised control trial in eight oncology centres across New South Wales and Victoria, Australia, is designed to assess the efficacy of a formal ACP intervention for patients with cancer...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27903984/association-between-xrcc1-polymorphisms-and-the-risk-of-cervical-cancer-a-meta-analysis-based-on-4895-subjects
#5
Xianling Zeng, Yafei Zhang, Ting Yue, Taohong Zhang, Junxia Wang, Yan Xue, Ruifang An
The present meta-analysis was intended to explore the relationship between the x-ray repair cross complementing 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and cervical cancer risk. Several electronic databases were searched systematically and bibliographies of relevant papers were identified carefully. Then, a meta-analysis was performed based on eligible studies in various genetic models. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were employed to evaluate the strength of associations between the XRCC1 polymorphisms and cervical cancer risk...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901404/military-veteran-cancer-survivors-preferences-for-a-program-to-address-lifestyle-change-and-psychosocial-wellness-following-treatment
#6
Gregory P Beehler, Jonathan Novi, Marc T Kiviniemi, Lynn Steinbrenner
OBJECTIVE: This study aimed to understand military veteran cancer survivors' preferences regarding the delivery of post-treatment wellness services. METHODS: Thirty-three military veteran cancer survivors were interviewed about their perceptions of three models of health service delivery (home-, primary care-, and oncology-based services). RESULTS: Conventional qualitative content analysis revealed strengths and weaknesses of each service delivery model's content and structure (e...
November 30, 2016: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#7
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27896952/muscle-strength-in-breast-cancer-patients-receiving-different-treatment-regimes
#8
Oliver Klassen, Martina E Schmidt, Cornelia M Ulrich, Andreas Schneeweiss, Karin Potthoff, Karen Steindorf, Joachim Wiskemann
BACKGROUND: Muscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals. METHODS: Breast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0-III and aged 54...
November 28, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895872/investigation-of-factors-affecting-body-temperature-changes-during-routine-clinical-head-magnetic-resonance-imaging
#9
Myeong Seong Kim
BACKGROUND: Pulsed radiofrequency (RF) magnetic fields, required to produce magnetic resonance imaging (MRI) signals from tissue during the MRI procedure have been shown to heat tissues. OBJECTIVES: To investigate the relationship between body temperature rise and the RF power deposited during routine clinical MRI procedures, and to determine the correlation between this effect and the body's physiological response. PATIENTS AND METHODS: We investigated 69 patients from the Korean national cancer center to identify the main factors that contribute to an increase in body temperature (external factors and the body's response) during a clinical brain MRI...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27891193/in-epithelial-cancers-aberrant-col17a1-promoter-methylation-predicts-its-misexpression-and-increased-invasion
#10
Pulari U Thangavelu, Tibor Krenács, Eloise Dray, Pascal H G Duijf
BACKGROUND: Metastasis is a leading cause of death among cancer patients. In the tumor microenvironment, altered levels of extracellular matrix proteins, such as collagens, can facilitate the first steps of cancer cell metastasis, including invasion into surrounding tissue and intravasation into the blood stream. However, the degree of misexpression of collagen genes in tumors remains understudied, even though this knowledge could greatly facilitate the development of cancer treatment options aimed at preventing metastasis...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27890964/association-of-the-mdm2-snp285-polymorphism-with-cancer-susceptibility-a-meta-analysis
#11
REVIEW
Ping Wang, Meilin Wang, Sanqiang Li, Lingjun Ma, Shoumin Xi, Jing He
The mouse double minute 2 (MDM2) gene encodes a negative regulator for p53, and the polymorphism SNP285 in the promoter region of MDM2 gene has been implicated in cancer risk, but individual published studies had inconclusive results. Therefore, we performed this meta-analysis to obtain a more precise estimation between MDM2 SNP285 polymorphism and risk of cancer. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 16 published studies comprising 14,573 cases and 9,115 controls were included...
2016: Disease Markers
https://www.readbyqxmd.com/read/27889645/suppression-of-tumor-growth-and-muscle-wasting-in-a-transgenic-mouse-model-of-pancreatic-cancer-by-the-novel-histone-deacetylase-inhibitor-ar-42
#12
Sally E Henderson, Li-Yun Ding, Xiaokui Mo, Tanios Bekaii-Saab, Samuel K Kulp, Ching-Shih Chen, Po-Hsien Huang
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. This study was aimed at evaluating the efficacy of AR-42 (formerly OSU-HDAC42), a novel histone deacetylase (HDAC) inhibitor currently in clinical trials, in suppressing tumor growth and/or cancer-induced muscle wasting in murine models of PDAC. EXPERIMENTAL DESIGN: The in vitro antiproliferative activity of AR-42 was evaluated in six human pancreatic cancer cell lines (AsPC-1, COLO-357, PANC-1, MiaPaCa-2, BxPC-3, SW1990)...
November 24, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27888817/the-role-of-an-electronic-questionnaires-in-epidemiologic-studies-aimed-at-cancer-prevention
#13
Maksymilian Gajda, Małgorzata Kowalska
The growing number of people diagnosed with cancer is an important issue in public health. Evaluation of the population’s level of cancer-related knowledge is mandatory for planning effective prevention or intervention programs. Until recently, traditional methodology, using paper questionnaire or telephone-based interviews had dominated previous cross sectional studies related to this issue. Currently, the use of new research methods based on information technology solutions has been more frequent. Therefore, the aim of this paper is to review published data available in the PubMed database towards the identification of strengths and weaknesses of crosssectional studies conducted via Internet, a type of information technology solution...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27886163/alghedon-fentanyl-transdermal-system-afts
#14
Patrizia Romualdi, Patrizia Santi, Sanzio Candeletti
The efficacy of transdermal fentanyl for cancer pain and chronic non-cancer pain (chronic lower back pain, rheumatoid arthritis, osteoarthritis, neuropathic pain) is well established. Several formulations of fentanyl transdermal systems have been developed to improve the drug delivery and prevent misuse of the active principle. The addition of a rate controlling membrane to the matrix system represented an important advance. The design and functional features of Alghedon patch are compared with other approved generic fentanyl transdermal systems, emphasizing the distinctiveness of Alghedon patch...
November 25, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27885308/pancreatic-cancer-a-survival-analysis-study-in-oklahoma
#15
Margaret Wahutu, Sara K Vesely, Janis Campbell, Anne Pate, Alicia L Salvatore, Amanda E Janitz
BACKGROUND: Pancreatic cancer is among the most deadly cancers. Risk factors associated with the disease include age, race, sex, smoking status, and diabetes status. METHOD: We conducted a prospective analysis of risk factors and length of survival among pancreatic cancer patients living in Oklahoma between 1997 and 2012 (n=6,291). Kaplan-Meier survival curves were created followed by the log-rank test to compare difference in the survival time. Cox proportional hazard regression models were used to examine the strength of association through the estimated hazard ratios...
July 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27885076/estimates-of-radiation-effects-on-cancer-risks-in-the-mayak-worker-techa-river-and-atomic-bomb-survivor-studies
#16
Dale L Preston, Mikhail E Sokolnikov, Lyudmila Yu Krestinina, Daniel O Stram
For almost 50 y, the Life Span Study cohort of atomic bomb survivor studies has been the primary source of the quantitative estimates of cancer and non-cancer risks that form the basis of international radiation protection standards. However, the long-term follow-up and extensive individual dose reconstruction for the Russian Mayak worker cohort (MWC) and Techa River cohort (TRC) are providing quantitative information about radiation effects on cancer risks that complement the atomic bomb survivor-based risk estimates...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27883164/sarcopenia-trials-in-specific-diseases-report-by-the-international-conference-on-frailty-and-sarcopenia-research-task-force
#17
B Vellas, R Fielding, S Bhasin, F Cerreta, B Goodpaster, J M Guralnik, S Kritchevsky, V Legrand, C Forkin, J Magaziner, J E Morley, L Rodriguez-Manas, R Roubenoff, S Studenski, D T Villareal, M Cesari
Muscle atrophy occurs as a consequence of a number of conditions, including cancer, chronic obstructive pulmonary disease (COPD), diabetes mellitus, heart failure, and other chronic diseases, where it is generally a predictor of poor survival. It also occurs as a consequence of disuse and an age-related loss of muscle mass and strength (sarcopenia). The aims of the 2016, International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force were to examine how these specific chronic conditions have been employed in treatment trials thus far and how future trials using these patient groups might be designed for efficient identification of effective sarcopenia interventions...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27878317/-what-is-currently-available-for-sport-medicine-therapy
#18
U Tegtbur
After 30 years of age physical capacity decreases with increasing age by 5-20% per decade. High physical activity in daily life as well as exercise training of endurance, strength, coordination and mobility can delay the functional and anatomical loss of muscle, bone, cartilage and connective tissue by more than 10 years. In recent years, numerous concepts have scientifically been proven in the exercise therapy of internal diseases; therefore, similar to drug treatment, cellular mechanisms of exercise training adaptation are known in detail...
December 2016: Der Internist
https://www.readbyqxmd.com/read/27875280/malnutrition-identified-by-the-academy-of-nutrition-and-dietetics-and-american-society-for-parenteral-and-enteral-nutrition-consensus-criteria-and-other-bedside-tools-is-highly-prevalent-in-a-sample-of-individuals-undergoing-treatment-for-head-and-neck-cancer
#19
Urvashi Mulasi, David M Vock, Adam J Kuchnia, Gautam Jha, Naomi Fujioka, Venkatesh Rudrapatna, Manish R Patel, Levi Teigen, Carrie P Earthman
BACKGROUND: Using the Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition (Academy/ASPEN) Consensus malnutrition definition, we estimated malnutrition prevalence in a sample of individuals with head and neck cancer (HNC) and compared it with the Patient-Generated Subjective Global Assessment (PG-SGA). We also investigated the utility of the 50-kHz phase angle (PA) and 200-kHz/5-kHz impedance ratio (IR) to identify malnutrition. MATERIALS AND METHODS: Nineteen individuals (18 males, 1 female) scheduled to undergo chemoradiotherapy were seen at 5 time points during and up to 3 months after treatment completion...
October 7, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27873046/commercially-available-lifestyle-modification-program-randomized-controlled-trial-addressing-heart-and-bone-health-in-brca1-2-breast-cancer-survivors-after-risk-reducing-salpingo-oophorectomy
#20
Kathleen M Sturgeon, Lorraine T Dean, Mariane Heroux, Jessica Kane, Toni Bauer, Erica Palmer, Jin Long, Shannon Lynch, Linda Jacobs, David B Sarwer, Mary B Leonard, Kathryn Schmitz
PURPOSE: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. METHODS: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed...
November 21, 2016: Journal of Cancer Survivorship: Research and Practice
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