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https://www.readbyqxmd.com/read/28549705/association-of-grip-strength-with-risk-of-all-cause-mortality-cardiovascular-diseases-and-cancer-in-community-dwelling-populations-a-meta-analysis-of-prospective-cohort-studies
#1
Yili Wu, Weijing Wang, Tianwei Liu, Dongfeng Zhang
OBJECTIVES: Grip strength has been linked to risk of adverse health outcomes. This study aimed to quantitatively assess the associations between grip strength and risk of all-cause mortality, cardiovascular diseases, and cancer in community-dwelling populations. DESIGN: A meta-analysis of prospective cohort studies was conducted. SETTING: Embase, Medline, and PubMed were searched from inception to September 14, 2016. Study-specific most adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were combined with a random effects model...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28548946/prognostic-role-of-lncrna-tug1-for-cancer-outcome-evidence-from-840-cancer-patients
#2
Jia Liu, Jieru Lin, Yingqi Li, Yunyuan Zhang, Xian Chen
LncRNA TUG1 has been demonstrated to be aberrantly expressed in several types of cancer and maybe serve as a prognostic marker for cancer patients. However, most individual studies have been limited by small sample sizes and controversial results. Therefore, this meta analysis was conducted to analyze available data to delineate the potential clinical application of lncRNA TUG1 on cancer prognosis, lymph node metastasis and tumor progression. Up to February 20, 2017, literature collections were conducted by comprehensive searching electronic databases, including Cochrane Library, PubMed, Embase, BioMed Central, Springer, ScienceDirect, ISI Web of Knowledge, together with three Chinese databases...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548695/development-of-a-novel-bioabsorbable-implant-that-is-substituted-by-adipose-tissue-in-vivo
#3
Shuichi Ogino, Naoki Morimoto, Michiharu Sakamoto, Chizuru Jinno, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Yuki Sakamoto, Tsuguyoshi Taira, Shigehiko Suzuki
Recently, adipose tissue has been regenerated by combining scaffolds, growth factors, and/or adipose tissue-derived stromal cells (ASCs). However, the safety of growth factors and ASCs has not been confirmed in cancer patients. We reported the regeneration of adipose tissue in the internal space of a polypropylene mesh containing a collagen sponge (CS), without using any growth factors or cells. We herein explored the formation of adipose tissue, using the bioabsorbable implant containing CS, in rats. We prepared the implants without and with CS, using threads of either poly l-lactide-co-ε-caprolactone [P(LA/CL)] or poly-l-lactic acid (PLLA), and measured their strengths...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28548122/recommendations-for-reporting-tumor-budding-in-colorectal-cancer-based-on-the-international-tumor-budding-consensus-conference-itbcc-2016
#4
Alessandro Lugli, Richard Kirsch, Yoichi Ajioka, Fred Bosman, Gieri Cathomas, Heather Dawson, Hala El Zimaity, Jean-François Fléjou, Tine Plato Hansen, Arndt Hartmann, Sanjay Kakar, Cord Langner, Iris Nagtegaal, Giacomo Puppa, Robert Riddell, Ari Ristimäki, Kieran Sheahan, Thomas Smyrk, Kenichi Sugihara, Benoît Terris, Hideki Ueno, Michael Vieth, Inti Zlobec, Phil Quirke
Tumor budding is a well-established independent prognostic factor in colorectal cancer but a standardized method for its assessment has been lacking. The primary aim of the International Tumor Budding Consensus Conference (ITBCC) was to reach agreement on an international, evidence-based standardized scoring system for tumor budding in colorectal cancer. The ITBCC included nine sessions with presentations, a pre-meeting survey and an e-book covering the key publications on tumor budding in colorectal cancer...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28547937/lack-of-association-of-the-fat-mass-and-obesity-associated-fto-gene-rs9939609-polymorphism-with-breast-cancer-risk-a-systematic-review-and-meta-analysis-based-on-case-control-studies
#5
Jamal Jafari Nedooshan, Saeed Kargar, Hossein Neamatzadeh, Fatemeh Haghighi, Reihaneh Dehghani Mohammad Abadi, Niloofar Seddighi
Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28546519/association-of-three-single-nucleotide-polymorphisms-of-esr1-with-breast-cancer-susceptibility-a-meta-analysis
#6
Xu Hu, Linfei Jiang, Chenhui Tang, Yuehong Ju, Li Jiu, Yongyue Wei, Guo Li, Zhao Yang
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms of ESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype...
April 6, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28545201/treatment-experiences-of-women-with-reproductive-cancers-in-odisha-india-a-qualitative-exploration-of-enablers-and-barriers
#7
Sanghamitra Pati, Abhimanyu Singh Chauhan, Sandeep Mahapatra, Sabita Nayak, Sukdev Nayak, David Weller
Introduction: Cancer continues to be a major menace to our Indian society notwithstanding significant progress in diagnosis and treatment. In India cancer mortality rates in women are high compared to other countries, despite efforts to improve survival through the development of effective detection techniques and increased numbers of viable treatment options. Indian women’s advanced stage of disease at diagnosis is largely attributable to delay in seeking treatment. The present qualitative inquiry was conducted with the aim of capturing the treatment experiences of patients with gynecology cancer at a tertiary care hospital and understanding the barriers, enablers, stress and apprehension they experience during the treatment phases...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544151/the-emt-spectrum-and-therapeutic-opportunities
#8
REVIEW
Dominic Chih-Cheng Voon, Ruby Yun-Ju Huang, Rebecca A Jackson, Jean Paul Thiery
Carcinomas are phenotypically arrayed along an EMT spectrum, a developmental program currently exploited to understand the acquisition of drug resistance through a re-routing of growth factor signalling. This review collates the current approaches employed in developing therapeutics against cancer-associated EMT, and provides an assessment of their respective strengths and drawbacks. We reflect on the close relationship between EMT and chemoresistance against current targeted therapeutics, with a special focus on the epigenetic mechanisms that links these processes...
May 24, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28542622/meta-analysis-of-magnetic-resonance-imaging-accuracy-for-diagnosis-of-oral-cancer
#9
Marcelo Aldrighi Moreira, Luiza Silveira Lessa, Francieli Regina Bortoli, Abigail Lopes, Eduardo Picolo Xavier, Renan Antonio Ceretta, Fernanda Guglielmi Faustini Sônego, Cristiane Damiani Tomasi, Patricia Duarte Simões Pires, Luciane Bisognin Ceretta, Ingrid Dalira Schweigert Perry, Priscyla Waleska Simões
OBJECTIVE: To establish the diagnostic accuracy of magnetic resonance imaging (MRI) as an auxiliary means for the diagnosis of oral cancer through a systematic review and meta-analysis. METHODS: An exhaustive search of publications from 1986 to 2016 was performed of Medline, Embase and Cochrane (and related databases), including grey literature. Primary diagnostic accuracy studies that assessed oral cancer (target condition) using MRI (index test) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28540249/liquid-biopsies-for-bladder-cancer
#10
EDITORIAL
Douglas G Ward, Richard T Bryan
The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management. A number of approaches are being utilised to address these challenges in both urinary- and plasma-borne tumour DNA (tDNA), so-called "liquid biopsies". Next generation sequencing (NGS) and droplet digital PCR (ddPCR) allow detection of very low levels of such tDNA amongst a large excess of non-tumour DNA, the former permitting large mutation panels to be assessed and the latter potentially identifying ultrarare mutant alleles yet restricted for multiplexing...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28536325/association-of-three-single-nucleotide-polymorphisms-of-esr1-with-breast-cancer-susceptibility-a-meta-analysis
#11
Xu Hu, Linfei Jiang, Chenhui Tang, Yuehong Ju, Li Jiu, Yongyue Wei, Guo Li, Zhao Yang
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms of ESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype...
April 6, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28536303/implementing-a-fee-for-service-cervical-cancer-screening-and-treatment-program-in-cameroon-challenges-and-opportunities
#12
Geneva DeGregorio, Simon Manga, Edith Kiyang, Florence Manjuh, Leslie Bradford, Preetam Cholli, Richard Wamai, Rebecca Ogembo, Zacharie Sando, Yuxin Liu, Lisa Kennedy Sheldon, Kathleen Nulah, Thomas Welty, Edith Welty, Javier Gordon Ogembo
BACKGROUND: Cervical cancer screening is one of the most effective cancer prevention strategies, but most women in Africa have never been screened. In 2007, the Cameroon Baptist Convention Health Services, a large faith-based health care system in Cameroon, initiated the Women's Health Program (WHP) to address this disparity. The WHP provides fee-for-service cervical cancer screening using visual inspection with acetic acid enhanced by digital cervicography (VIA-DC), prioritizing care for women living with HIV/AIDS...
May 23, 2017: Oncologist
https://www.readbyqxmd.com/read/28536262/in-silico-and-cell-based-analyses-reveal-strong-divergence-between-prediction-and-observation-of-t-cell-recognized-tumor-antigen-t-cell-epitopes
#13
Julien Schmidt, Philippe Guillaume, Danijel Dojcinovic, Julia Karbach, George Coukos, Immanuel Luescher
Tumor exomes provide comprehensive information on mutated, over-expressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T cell epitopes, because neoepitope specific T cells often are tumoricidal. However, identifying tumor-specific T cell epitopes is a major challenge. A widely used strategy relies on initial prediction of human leukocyte antigen binding peptides by in silico algorithms, but the predictive power of this approach is unclear...
May 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28530213/-the-model-of-perioperative-risk-assessment-in-elderly-patients-interim-analysis
#14
Izabela Grabowska, Lucyna Ścisło, Szymon Pietruszka, Elzbieta Walewska, Agata Paszko, Benita Siarkiewicz, Piotr Richter, Andrzej Budzyński, Antoni M Szczepanik
Demographic changes in contemporary society require implementation of proper perioperative care of elderly patients due to an increased risk of perioperative complications in this group. Preoperative assessment of health status identifies risks and enables preventive interventions, improving outcomes of surgical treatment. The Comprehensive Geriatric Assessment contains numerous diagnostic tests and consultations, which is expensive and difficult to use in everyday practice. The development of a simplified model of perioperative assessment of elderly patients will help identifying the group of patients who require further diagnostic workup...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28529190/development-and-evaluation-of-an-interdisciplinary-postoperative-support-program-in-outpatient-clinics-after-thoracic-esophagectomy
#15
Takeo Fujita, Yoko Iida, Chihau Tanaka, Kumi Nakamura, Keiko Yamanaka, Junya Ueno, Yoshie Iino, Chitose Haruka, Hatoe Sakamoto, Hiroyuki Daiko
BACKGROUND: To support patients discharged from the hospital after surgery, we launched an "Interdisciplinary Postoperative Support Program" in outpatient clinics for patients who were discharged within 1 month after thoracic esophagectomy and their families. We introduce our program and clarify the patient's physical and psychologic status by analyzing the questionnaire provided from this program. MATERIALS AND METHODS: From August 2014 to January 2015, we conducted the Interdisciplinary Postoperative Support Program every month...
May 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28528350/prevalence-and-impact-of-severe-fatigue-in-adolescent-and-young-adult-cancer-patients-in-comparison-with-population-based-controls
#16
Hanneke Poort, Suzanne E J Kaal, Hans Knoop, Rosemarie Jansen, Judith B Prins, Eveliene Manten-Horst, Petra Servaes, Olga Husson, Winette T A van der Graaf
PURPOSE: The current study determined the prevalence of severe fatigue in adolescent and young adult (AYA) cancer patients (aged 18-35 years at diagnosis) consulting a multidisciplinary AYA team in comparison with gender- and age-matched population-based controls. In addition, impact of severe fatigue on quality of life and correlates of fatigue severity were examined. METHODS: AYAs with cancer (n = 83) completed questionnaires including the Checklist Individual Strength (CIS-fatigue), Quality of Life (QoL)-Cancer Survivor, Hospital Anxiety and Depression Scale (reflecting psychological distress), and the Cancer Worry Scale (reflecting fear of cancer recurrence or progression)...
May 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28524909/nonpharmacologic-pain-interventions-a-review-of-evidence-based-practices-for-reducing-chronic-cancer-pain%C3%A2
#17
Linda H Eaton, Jeannine M Brant, Karen McLeod, Chao Yeh
BACKGROUND: Pain is a common issue for patients with cancer and can be challenging to manage effectively. Healthcare professionals need to be knowledgeable about evidence-based nonpharmacologic interventions.
. OBJECTIVES: This systematic review critically appraises the strength and quality of the empirical evidence for nonpharmacologic interventions in reducing chronic cancer pain.
. METHODS: Intervention studies were critically appraised and summarized by an Oncology Nursing Society Putting Evidence Into Practice team of RNs, advanced practice nurses, and nurse scientists...
June 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28524706/cachexia-stage-patient-generated-subjective-global-assessment-phase-angle-and-handgrip-strength-in-patients-with-gastrointestinal-cancer
#18
Gislaine Aparecida Ozorio, Katia Barão, Nora Manoukian Forones
The aim of this study was to correlate patients with gastrointestinal cancer, classified according to different stages of cancer cachexia (SCC) as proposed by Fearon, with nutritional assessment tools such as PG-SGA, phase angle (PA), and handgrip strength. One hundred one patients with a mean age of 61.8 ± 12.8 yr, with 58.4% being men were included. 32.6% were malnourished according to the body mass index (BMI). A severe or moderate malnutrition had been diagnosed in 63.3% when assessed using the PG-SGA, 60...
May 19, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28507015/preserving-healthy-muscle-during-weight-loss
#19
REVIEW
Edda Cava, Nai Chien Yeat, Bettina Mittendorfer
Weight loss is the cornerstone of therapy for people with obesity because it can ameliorate or completely resolve the metabolic risk factors for diabetes, coronary artery disease, and obesity-associated cancers. The potential health benefits of diet-induced weight loss are thought to be compromised by the weight-loss-associated loss of lean body mass, which could increase the risk of sarcopenia (low muscle mass and impaired muscle function). The objective of this review is to provide an overview of what is known about weight-loss-induced muscle loss and its implications for overall physical function (e...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28504538/self-efficacy-for-coping-with-cancer-revision-of-the-cancer-behavior-inventory-version-3-0
#20
Thomas V Merluzzi, Errol J Philip, Carolyn A Heitzmann Ruhf, Haiyan Liu, Miao Yang, Claire C Conley
Based on self-regulation and self-efficacy theories, the Cancer Behavior Inventory (CBI; Heitzmann et al., 2011; Merluzzi & Martinez Sanchez, 1997; Merluzzi, Nairn, Hegde, Martinez Sanchez, & Dunn, 2001) was developed as a measure of self-efficacy strategies for coping with cancer. In the latest revision, CBI-V3.0, a number of psychometric and empirical advances were made: (a) the reading level was reduced to 6th-grade level; (b) individual interviews and focus groups were used to revise items; (c) a new spiritual coping subscale was added; (d) data were collected from 4 samples (total N = 1,405) to conduct an exploratory factor analysis with targeted rotation, 2 confirmatory factor analyses, and differential item functioning; (e) item trimming was used to reduce the total number to 27; (f) internal consistency and test-retest reliability were computed; and (g) extensive validity testing was conducted...
May 15, 2017: Psychological Assessment
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