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https://www.readbyqxmd.com/read/28339318/predictors-for-lymph-nodes-involvement-in-low-risk-endometrial-cancer
#1
Yfat Kadan, Abdul Saied Calvino, Andrew Katz, Steven Katz, Richard G Moore
Neutrophil-lymphocyte ratio (NLR) and BMI were examined as pre-operative predictors for lymph node metastases in patients with low-risk endometrial cancer. The study was a retrospective analysis of 534 endometrial cancer patients that underwent hysterectomy and lymph node dissection. Included subjects had a preoperative diagnosis of a grade 1 or 2 endometrioid carcinoma and no macroscopic extrauterine disease. We compared node-negative to node-positive patients to identify correlates of node-positive disease...
March 24, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28339064/extracellular-matrix-metabolism-disorder-induced-by-mechanical-strain-on-human-parametrial-ligament-fibroblasts
#2
Jie Min, Bingshu Li, Cheng Liu, Wenjun Guo, Shasha Hong, Jianming Tang, Li Hong
Pelvic organ prolapse (POP) is a global health problem that may seriously impact the quality of life of the sufferer. The present study aimed to investigate the potential mechanisms underlying alterations in extracellular matrix (ECM) metabolism in the pathogenesis of POP, by investigating the expression of ECM components in human parametrial ligament fibroblasts (hPLFs) subject to various mechanical strain loads. Fibroblasts derived from parametrial ligaments were cultured from patients with POP and without malignant tumors, who underwent vaginal hysterectomy surgery...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338206/impact-and-clinical-significance-of-embosphere-microsphere-artery-embolization-therapy-in-serum-vegf-expression-level-of-women-patients-with-uterine-fibroids
#3
H-X Ge, W Xu, D-Q Du, A-J Wang
OBJECTIVE: We aimed to investigate the effect of Embosphere microsphere artery embolization on the serum level of vascular endothelial growth factor (VEGF) in patients with uterine fibroid. PATIENTS AND METHODS: From March 2014 to December 2015, 128 women in child-bearing age with uterine intramural fibroids were enrolled in the patient group. At the same time, 128 healthy cases in child-bearing age were randomly selected and enrolled in the control group. Enzyme-linked immunosorbent assay was used to measure the serum level of VEGF, and immunohistochemical staining method was used to study the expression of VEGF in the uterine fibroids...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28336363/does-surgical-teaching-take-time-resident-participation-in-minimally-invasive-hysterectomy-for-endometrial-cancer
#4
Alexandra H Freeman, Allison Barrie, Liisa Lyon, Carol Conell, Christine Garcia, Ramey D Littell, C Bethan Powell
STUDY OBJECTIVE: To determine the association between resident involvement and operative time for minimally invasive surgery (MIS) for endometrial cancer. DESIGN: Retrospective cohort study DESIGN: Classification: II-2 SETTING: Integrated health care system in Northern California PATIENTS: A total of 1,433 women who underwent MIS for endometrial cancer and endometrial intraepithelial neoplasia from January 2009 to January 2014. INTERVENTIONS: Resident participation in 430/688 laparoscopic cases (62%) and 341/745 robotic cases (46%)...
March 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28335653/anesthesia-management-of-complete-versus-incomplete-placenta-previa-a-retrospective-cohort-study
#5
Sharon Orbach-Zinger, Carolyn F Weiniger, Amir Aviram, Alexander Balla, S Fein, L A Eidelman, A Ioscovich
PURPOSE: Placenta previa (PP) is a major cause of obstetric hemorrhage. Clinical diagnosis of complete versus incomplete PP has a significant impact on the peripartum outcome. Our study objective is to examine whether distinction between PP classifications effect anesthetic management. METHODS AND MATERIALS: This multi center, retrospective, cohort study was performed in two tertiary university-affiliated medical centers between the years 2005- 2013. Electronic delivery databases were reviewed for demographic, anesthetic, obstetric hemorrhage, and postoperative outcomes for all cases...
March 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28333263/loss-of-luteotropic-prostaglandin-e-plays-an-important-role-in-the-regulation-of-luteolysis-in-women
#6
Junko Nio-Kobayashi, Masataka Kudo, Noriaki Sakuragi, Toshihiko Iwanaga, W Colin Duncan
STUDY QUESTION: Do intraluteal prostaglandins (PG) contribute to luteal regulation in women? SUMMARY ANSWER: Prostaglandin E (PGE), which is produced in human granulosa-lutein cells stimulated with luteotropic hCG, exerts similar luteotropic effects to hCG, and the expression of PG synthetic and metabolic enzymes in the human CL is driven toward less PGE but more prostaglandin F (PGF) during luteolysis. WHAT IS KNOWN ALREADY: Uterine PGF is a major luteolysin in many non-primate species but not in women...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28320479/correlates-of-circulating-ovarian-cancer-early-detection-markers-and-their-contribution-to-discrimination-of-early-detection-models-results-from-the-epic-cohort
#7
Renée T Fortner, Allison F Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Giuseppe Matullo, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, María Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Jenny Brändstedt, Annika Idahl, Kay-Tee Khaw, Naomi Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks, Kathryn L Terry
BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases)...
March 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28319574/melf-pattern-for-predicting-lymph-node-involvement-and-survival-in-grade-i-ii-endometrioid-type-endometrium-cancer
#8
Muzaffer Sanci, Kemal Güngördük, Varol Gülseren, Tuğba Karadeniz, Mustafa Kocaer, Ozgu Gungorduk, İsa A Özdemir
The aim of this study was to examine the associations between microcystic, elongated, and fragmented (MELF) pattern and other prognostic factors and lymph node involvement, disease-free survival, and overall survival (OS) using a case-control group consisting of grade I-II endometrioid endometrial carcinoma (EEC) patients with/without lymph node involvement. The files of the patients were searched electronically for all hysterectomy specimens with a diagnosis of grade I-II EEC of the uterine body from January 1, 2008 to July 31, 2014...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28314056/joint-modeling-of-zero-inflated-panel-count-and-severity-outcomes
#9
E Juarez-Colunga, G L Silva, C B Dean
Panel counts are often encountered in longitudinal, such as diary, studies where individuals are followed over time and the number of events occurring in time intervals, or panels, is recorded. This article develops methods for situations where, in addition to the counts of events, a mark, denoting a measure of severity of the events, is recorded. In many situations there is an association between the panel counts and their marks. This is the case for our motivating application that studies the effect of two hormone therapy treatments in reducing counts and severities of vasomotor symptoms in women after hysterectomy/ovariectomy...
March 17, 2017: Biometrics
https://www.readbyqxmd.com/read/28287013/a-different-technique-in-gasless-laparoendoscopic-single-site-hysterectomy
#10
Gökhan Demirayak
The aim of this study was to show a different technique for a gasless laparoendoscopic single-site (LESS) hysterectomy and to present advantages and limitations of this technique. Women undergoing gasless LESS hysterectomy with a different technique were evaluated. A total of 14 LESS hysterectomies were performed using this gasless technique and rigid laparoscopic instruments by one surgeon. The mean age of the patients was 48.6 (±4.6). The average blood loss was 80 ± 35 ml. The average time between an umbilical incision and starting hysterectomy was 5 (±2,1) min...
March 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28285572/optimal-timing-for-performing-hysterectomy-according-to-different-phase-of-menstrual-cycle-which-is-best
#11
Jeong Jin Kim, Jun Hyeok Kang, Kyo Won Lee, Kye Hyun Kim, Taejong Song
The aim of this study was to determine whether the different phases of the menstrual cycle could affect operative bleeding in women undergoing laparoscopic hysterectomy. This was a retrospective comparative study. Based on the adjusted day of menstrual cycle, 212 women who underwent laparoscopic hysterectomy were classified into three groups: the follicular phase (n = 51), luteal phase group (n = 125), and menstruation group (n = 36). The primary outcome measure was the operative bleeding. There was no difference in the baseline characteristics of the patients belonging to the three groups...
March 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28285341/improved-quality-of-risk-reducing-salpingo-oophorectomy-in-australasian-women-at-high-risk-of-pelvic-serous-cancer
#12
Y C Lee, M Bressel, P Grant, P Russell, C Smith, S Picken, S Camm, B E Kiely, R L Milne, S A McLachlan, M Hickey, M L Friedlander, J L Hopper, K A Phillips
OBJECTIVES: The quality of risk-reducing salpingo-oophorectomy (RRSO) performed in Australasian women was previously reported to be suboptimal. Here we describe the quality of RRSO performed since 2008 in women enrolled in the same cohort and determine whether it has improved. DESIGN: Prospective cohort study of women at high risk of pelvic serous cancer (PSC) in kConFab. Eligible women had RRSO between 2008 and 2014 and their RRSO surgical and pathology reports were reviewed...
March 11, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28283262/uterine-viability-in-the-baboon-after-ligation-of-uterine-vasculature-a-pilot-study-to-assess-alternative-perfusion-and-venous-return-for-uterine-transplantation
#13
Marie Shockley, Katrin Arnolds, Benjamin Beran, Krishna Rivas, Pedro Escobar, Andreas Tzakis, Tommaso Falcone, Michael L Sprague, Stephen Zimberg
OBJECTIVE: To assess, in two separate groups of baboons, uterine viability after ligation of the uterine veins and uterine viability after ligation of both the uterine arteries and veins, respectively. DESIGN: Prospective, observational study. SETTING: Baboon breeding colony. ANIMAL(S): Six naïve female Papio hamadryas baboons with indicators of normal reproductive function. INTERVENTION(S): Three baboons underwent surgical interruption of the uterine veins bilaterally, and three baboons underwent surgical interruption of the uterine arteries and the uterine veins bilaterally...
March 7, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28277596/the-mccarus-volker-fornisee%C3%A2-a-novel-trans-illuminating-colpotomy-device-and-uterine-manipulator-for-use-in-conventional-and-robotic-assisted-laparoscopic-hysterectomy
#14
Melissa M Gutierrez, Jasmine D Pedroso, K Warren Volker, David L Howard, Steven D McCarus
PURPOSE: The purpose of this paper is to introduce a novel trans-illuminating culdotomy and uterine manipulator device. MATERIALS AND METHODS: The study was a prospective, non-randomized, non-blinded observational clinical study involving 50 female patients undergoing total laparoscopic hysterectomy (TLH) or laparoscopic supracervical hysterectomy (LSH) for benign indications. The surgeries were performed from March through May 2012 at two institutions. The primary study objectives were to demonstrate the safety and adequate clinical performance of the uterine manipulator device and to illustrate its potential widespread future use in minimally invasive gynecologic procedures...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28277472/transvaginal-repair-of-complex-rectovaginal-fistulas-using-the-porcine-urinary-bladder-matrix-as-an-augmenting-graft
#15
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: After the US Food and Drug Administration issued a safety warning concerning vaginal mesh implants in 2008, their use in correction of pelvic floor defects have decreased in the United States (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm479732.htm). However, we are still treating patients who have had complications associated with their use, rectovaginal fistulas (RVFs) being one of them. Rectovaginal fistulas are considered complex if greater than 2.5 cm, recurrent, associated with inflammatory bowel disease, or if they are proximal in location...
March 9, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28272673/comparison-of-three-different-new-bipolar-energy-modalities-and-classic-bipolar-in-vivo-for-tissue-thermal-spread
#16
Melike Demir Çaltekin, Serpil Aydoğmuş, Serenat Eriş Yalçin, Emine Demirel, Fulya Cakalağaoğlu Unay, Pelin Özün Özbay, Aslı Özdemir, Yakup Yalçin, Sefa Kelekçi
OBJECTIVE: The aim of this study was to compare three different new bipolar energy modalities and classic bipolar in vivo for tissue thermal spread. MATERIAL AND METHOD: This prospective, randomized, single-blind study was conducted between Septemsber 2012 and July 2013. Eighteen patients aged 40-65 years undergoing hysterectomy and bilateral salpingectomy for benign etiology were included in the study. Before the hysterectomy operation began, it was marked nearly distal third cm started from uterine corn and proximal close third cm started from fimbrial bottoms by visualizing both fallopian tubes...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272250/oxycodone-versus-fentanyl-for-intravenous-patient-controlled-analgesia-after-laparoscopic-supracervical-hysterectomy-a-prospective-randomized-double-blind-study
#17
RANDOMIZED CONTROLLED TRIAL
Nan Seol Kim, Jeong Seok Lee, Su Yeon Park, Aeli Ryu, Hea Rim Chun, Ho Soon Chung, Kyou Sik Kang, Jin Hun Chung, Kyung Taek Jung, Seong Taek Mun
BACKGROUND: Oxycodone, a semisynthetic thebaine derivative opioid, is widely used for the relief of moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl in the management of postoperative pain by intravenous patient-controlled analgesia (IV-PCA) in patients who underwent laparoscopic supracervical hysterectomy (LSH). METHODS: The 127 patients were randomized to postoperative pain treatment with either oxycodone (n = 64, group O) or fentanyl group (n = 63, group F)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28268196/prenatal-ultrasound-diagnosis-and-outcome-of-placenta-previa-accreta-after-caesarean-delivery-a-systematic-review-and-meta-analysis
#18
REVIEW
Eric Jauniaux, Amar Bhide
BACKGROUND: Women with a history of previous caesarean delivery, presenting with a placenta previa have become the largest group with the highest risk for placenta previa accreta. OBJECTIVE: To evaluate the accuracy of ultrasound imaging in the prenatal diagnosis of placenta accreta and the impact of the depth of villous invasion on management in women presenting with placenta previa or low-lying placenta and with one or more prior caesarean deliveries. STUDY DESIGN: Data sources: We searched PubMed, Google Scholar, clinicalTrials...
March 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28266815/efficacy-and-safety-of-elevate%C3%A2-system-on-apical-and-anterior-compartment-prolapse-repair-with-personal-technique-modification
#19
Daniele Castellani, Vikiela Galica, Pietro Saldutto, Giuseppe Paradiso Galatioto, Carlo Vicentini
AIM: To evaluate the effectiveness and safety of Anterior Elevate® mesh kit system (AES) in woman with symptomatic stage 3 or 4 anterior and/or apical pelvic organ prolapse (POP). MATERIALS AND METHODS: This retrospective, monocentric, single surgeon study enrolled between May 2010 and January 2013 fifty-six woman experiencing symptomatic anterior vaginal prolapse with or without apical descent (POP-Q stage 3 or 4). All women received a AES and 7 (12.5%) received a concomitant transvaginal hysterectomy...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28265843/validity-of-self-reported-fertility-threatening-cancer-treatments-in-female-young-adult-cancer-survivors
#20
Samantha C Roberts, Amber Knight, Brian W Whitcomb, Jessica R Gorman, Andrew C Dietz, H Irene Su
PURPOSE: Detailed cancer treatment information is important to fertility and pregnancy care of female young adult cancer survivors. Accuracy of self-report of treatments that impact fertility and pregnancy is unknown. This study assessed agreement between self-report and medical records on receipt of fertility-threatening treatments. METHODS: A national cohort study of female young adult cancer survivors reported cancer treatments via Web-based questionnaires. Primary cancer treatment records were abstracted...
March 6, 2017: Journal of Cancer Survivorship: Research and Practice
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