S Petta, E Vanni, E Bugianesi, C Rosso, D Cabibi, C Cammà, V Di Marco, M Eslam, S Grimaudo, F S Macaluso, D McLeod, R M Pipitone, M L Abate, A Smedile, J George, A Craxì
BACKGROUND: The PNPLA3/Adiponutrin rs738409 C/G single nucleotide polymorphism is associated with the severity of steatosis, steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease, as well as the severity of steatosis and fibrosis in patients with chronic hepatitis C (CHC). AIM: To test in genotype 1(G1)-CHC patients, the putative association between the PNPLA3 variant and histological features of steatohepatitis, as well as their impact on the severity of fibrosis...
May 2015: Alimentary Pharmacology & Therapeutics