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https://www.readbyqxmd.com/read/29434271/adherence-and-quality-of-life-in-adults-and-children-during-3-years-of-slit-treatment-with-grazax-a-real-life-study
#1
Hampus Kiotseridis, Peter Arvidsson, Vibeke Backer, Vagn Braendholt, Alf Tunsäter
Respiratory allergic disease represents a global health problem, 30% of the population suffers from allergic rhinoconjunctivitis and 20% suffer from asthma. Allergy immunotherapy induce immunological tolerance and thereby modify the response to allergens and sublingual immunotherapy (SLIT) offers the possibility of home administration of allergen therapy, but adherence is more uncertain. The aim of the study was to investigate the adherence with GRAZAX in adults and children ≥ 5 years during three consecutive years of treatment...
February 12, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29433792/clinical-characteristics-of-influenza-virus-induced-lower-respiratory-infection-during-the-2015-to-2016-season
#2
Kazuhiro Uda, Kensuke Shoji, Chitose Koyama-Wakai, Munehiro Furuichi, Noriyasu Iwase, Seiichiro Fujisaki, Shinji Watanabe, Isao Miyairi
BACKGROUND: Influenza A(H1N1)pdm09 virus infections often manifest severe respiratory symptoms, particularly in patients with a past history of allergic disease. Most of these findings were reported during the 2009 pandemic. The purpose of this study was to detail the clinical characteristics of influenza virus-induced lower respiratory infection (LRI) during the A(H1N1)pdm09-predominant 2015-2016 season. METHODS: We retrospectively reviewed the clinical characteristics of influenza-induced LRI cases in children admitted to a tertiary children's hospital...
February 9, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29422821/twenty-years-observation-of-subcutaneous-pollen-allergoid-immunotherapy-efficacy-in-adults
#3
Andrzej Bożek, Izabella Krupa-Borek, Jerzy Jarzab
Introduction: It is valuable to determine the long-term efficacy of allergen-specific immunotherapy (SIT) and whether it can cure allergy. Aim: For this study, patients were prospectively observed for 20 years after completion of SIT to determine its effectiveness. Material and methods: A total of 1006 patients who underwent SIT for pollen allergy were observed for 20 years to assess the efficacy of SIT. The rhinitis symptom score (RSS) and asthma symptom score (ASS) were measured after SIT completion...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29402620/monitoring-of-mycoflora-in-outdoor-air-of-different-localities-of-ahvaz-iran
#4
M Fatahinia, A Zarei-Mahmoudabadi, H Shokri, H Ghaymi
INTRODUCTION: Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols and their density in the air is highly regarded. Identifying fungi with common mycological methods as well as molecular about 5% of people are prone to allergic symptoms of the respiratory tract caused by molds during their lives...
February 2, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29379542/clinical-and-immunological-effects-of-vitamin-d-supplementation-during-the-pollen-season-in-children-with-allergic-rhinitis
#5
Joanna Jerzyńska, Włodzimierz Stelmach, Błażej Rychlik, Paweł Majak, Daniela Podlecka, Katarzyna Woicka-Kolejwa, Iwona Stelmach
Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. Material and methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29361332/safety-and-efficacy-of-immunotherapy-with-the-recombinant-b-cell-epitope-based-grass-pollen-vaccine-bm32
#6
Verena Niederberger, Angela Neubauer, Philippe Gevaert, Mihaela Zidarn, Margitta Worm, Werner Aberer, Hans Jørgen Malling, Oliver Pfaar, Ludger Klimek, Wolfgang Pfützner, Johannes Ring, Ulf Darsow, Natalija Novak, Roy Gerth van Wijk, Julia Eckl-Dorna, Margarete Focke-Tejkl, Milena Weber, Hans-Helge Müller, Joachim Klinger, Frank Stolz, Nora Breit, Rainer Henning, Rudolf Valenta
BACKGROUND: BM32 is a grass pollen allergy vaccine based on recombinant fusion proteins consisting of nonallergenic peptides from the IgE-binding sites of the 4 major grass pollen allergens and the hepatitis B preS protein. OBJECTIVE: We sought to study the safety and clinical efficacy of immunotherapy (allergen immunotherapy) with BM32 in patients with grass pollen-induced rhinitis and controlled asthma. METHODS: A double-blind, placebo-controlled, multicenter allergen immunotherapy field study was conducted for 2 grass pollen seasons...
January 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350019/cypress-pollen-allergy-is-responsible-for-two-distinct-phenotypes-of-allergic-rhinitis-different-from-other-pollinosis
#7
L Pahus, M Gouitaa, T Sofalvi, K Alagha, D Gras, P Chanez, D Charpin
Different phenotypes of allergic rhinitis have been identified based on the seasonality of the allergen involved. Within pollinosis, importance has to be paid to the responsible pollen species. Guidelines for clinical management are mostly based on studies performed in patients with grass pollen allergy. Only few data is available on tree pollen allergy and more specifically on cypress pollen allergy. We focused on the clinical and biological features of cypress pollen allergy to determine whether it is associated with a specific phenotype of allergic rhinitis or not...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29343309/could-seasonal-allergy-be-a-risk-factor-for-acute-rhinosinusitis-in-children
#8
G Leo, C Incorvaia, A Cazzavillan, D Consonni, G V Zuccotti
OBJECTIVE: To evaluate the incidence of acute rhinosinusitis in children with grass pollen induced rhinitis during the period of grass pollinosis. METHODS: Children with nasal symptoms from grass pollen induced rhinitis but without rhinosinusitis symptoms were selected. Their parents were asked to complete a diary during pollen exposure to report nasal symptoms and drugs used daily. When rhinosinusitis was suspected, the confirmatory diagnosis of acute rhinosinusitis was made by fibro-endoscopy...
January 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29340327/trimethoprim-sulfamethoxazole-reduces-rates-of-melioidosis-in-high-risk-hemodialysis-patients
#9
Sandawana William Majoni, Jaquelyne T Hughes, Bianca Heron, Bart J Currie
Introduction: Melioidosis causes sepsis and death in the Top End of Northern Australia during the monsoonal wet season. Dialysis-dependent adults suffer higher melioidosis rates compared to low rates among renal transplant patients who routinely receive trimethoprim+sulfamethoxazole prophylaxis. Methods: We performed a prospective interventional study to determine the efficacy and safety of daily trimethoprim+sulfamethoxazole prophylaxis in hemodialysis patients during the wet season, from 1 November 2014 to 30 April 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29315922/the-use-of-omalizumab-in-allergen-immunotherapy
#10
Jennifer A Dantzer, Robert A Wood
Although omalizumab (anti-IgE) is currently only approved for the treatment of asthma and chronic idiopathic urticaria, it has also been studied as an off-label treatment for numerous allergic conditions, including use as an adjunct to allergen immunotherapy in the treatment of allergic rhinitis, asthma, venom hypersensitivity, and food allergy. We conducted a review of publications involving the use of omalizumab with allergen immunotherapy, by searching PubMed with key search terms of "omalizumab" and "immunotherapy...
January 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29310846/inhalant-allergen-sensitization-is-an-independent-risk-factor-for-the-development-of-angioedema
#11
Jacob E Kuperstock, Nicholas Pritchard, Michal Horný, Christopher C Xiao, Christopher D Brook, Michael P Platt
BACKGROUND/OBJECTIVE: The etiology and risk factors for angioedema remain poorly understood with causative triggers often going undiagnosed despite repeated reactions. The purpose of this study was to determine the relationship between inhalant allergen sensitization and angioedema. METHODS: A retrospective review of patients who had in vitro inhalant allergy testing from 2006 to 2010 was performed. Patients with a diagnosis of angioedema who underwent inhalant allergy testing were identified...
December 27, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29291522/aqueous-and-organic-extract-of-pm2-5-collected-in-different-seasons-and-cities-of-japan-differently-affect-respiratory-and-immune-systems
#12
Pratiti Home Chowdhury, Hitoshi Okano, Akiko Honda, Hitomi Kudou, Gaku Kitamura, Sho Ito, Kayo Ueda, Hirohisa Takano
Particulate matter with diameters <2.5 μm (i.e., PM2.5) has multiple natural and anthropological sources. The association between PM2.5 and the exacerbation of respiratory allergy and asthma has been well studied, but the components of PM2.5 that are responsible for allergies have not yet been determined. Here, we elucidated the effects of aqueous and organic extract of PM2.5 collected during four seasons in November 2014-December 2015 in two cities (Kawasaki, an industrial area and Fukuoka, an urban area affected by transboundary pollution matter) of Japan on respiratory health...
December 28, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29287194/potential-role-of-propolis-in-wound-healing-biological-properties-and-therapeutic-activities
#13
REVIEW
Ahmad Oryan, Esmat Alemzadeh, Ali Moshiri
Propolis is a resinous mixture that honey bees collect from the tree buds, sap flows, or other botanical sources. The chemical composition of propolis varies and depends on the geographical area, time of collection, seasonality, illumination, altitude, and food availability during propolis exploitation. The goal of this review is to discuss important concepts including mechanisms of action and therapeutic activities of propolis. The PubMed, ScienceDirect, and Cochrane Library databases were searched for the literature published from January the 1st 2000 to October the 1st 2017...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29279263/tear-osteopontin-level-and-its-relationship-with-local-th1-th2-th17-treg-cytokines-in-children-with-allergic-conjunctivitis
#14
A Yan, G Luo, Z Zhou, W Hang, D Qin
BACKGROUND: Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC. METHODS: Eighty AC children (seasonal and perennial AC) and twenty controls were enrolled in this study. Serum and tears of different time points (during and out of the pollen season) were collected and used for enzyme-linked immunosorbent assay (ELISA) of OPN and T-help cell related cytokines, respectively...
December 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29279062/comparison-of-the-effect-of-5-grass-pollen-sublingual-immunotherapy-tablets-and-drops-in-children-with-rhinoconjunctivitis
#15
Joanna Jerzynska, Wlodzimierz Stelmach, Pawel Majak, Rafal Stelmach, Anna Janas, Iwona Stelmach
BACKGROUND: One of the most important aspects of sublingual immunotherapy (SLIT) is the regimen of administration. AIM: To find any differences in symptom-medication scores between the two groups of SLIT tablets and drops, given pre-coseasonally (starting 8 weeks before the pollen season) in children with rhinoconjunctivitis allergy to grass pollen. The secondary outcome were the differences in lung function and induction of T-regulatory forkhead box P3 (FOXP3) positive cells...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29240930/britain-breathing-using-the-experience-sampling-method-to-collect-the-seasonal-allergy-symptoms-of-a-country
#16
Markel Vigo, Lamiece Hassan, William Vance, Caroline Jay, Andrew Brass, Sheena Cruickshank
Objective: Allergies are increasing, but the reasons for this are unclear. Although environmental factors are thought to be important, there is a lack of data on how they contribute to symptom development. To understand this relationship better, we need accurate data about both symptoms and environmental factors. Our objective here is to ascertain whether experience sampling is a reliable approach for collecting allergy symptom data in the general population, allowing us to map symptoms and understand etiology...
December 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29238339/comparing-the-healthy-nose-and-nasopharynx-microbiota-reveals-continuity-as-well-as-niche-specificity
#17
Ilke De Boeck, Stijn Wittouck, Sander Wuyts, Eline F M Oerlemans, Marianne F L van den Broek, Dieter Vandenheuvel, Olivier Vanderveken, Sarah Lebeer
To improve our understanding of upper respiratory tract (URT) diseases and the underlying microbial pathogenesis, a better characterization of the healthy URT microbiome is crucial. In this first large-scale study, we obtained more insight in the URT microbiome of healthy adults. Hereto, we collected paired nasal and nasopharyngeal swabs from 100 healthy participants in a citizen-science project. High-throughput 16S rRNA gene V4 amplicon sequencing was performed and samples were processed using the Divisive Amplicon Denoising Algorithm 2 (DADA2) algorithm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29233481/road-traffic-noise-and-determinants-of-saliva-cortisol-levels-among-adolescents
#18
Alva Wallas, Charlotta Eriksson, Olena Gruzieva, Tomas Lind, Andrei Pyko, Mattias Sjöström, Mikael Ögren, Göran Pershagen
OBJECTIVES: The understanding of determinants for saliva cortisol levels in adolescents is limited. This study investigated the role of road traffic noise exposure, noise annoyance and various other factors for saliva cortisol levels. METHODS: We collected morning and evening saliva samples from 1751 adolescents from the BAMSE birth cohort based in Stockholm County. Façade noise levels from road traffic were estimated at the residences of the study subjects and repeated questionnaires and medical examinations provided extensive information on various exposures and conditions, including annoyance to noise from different sources...
November 22, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29220768/analysis-of-airborne-olea-pollen-in-cartagena-spain
#19
M D Galera, B Elvira-Rendueles, J M Moreno, L Negral, M C Ruiz-Abellón, A García-Sánchez, S Moreno-Grau
Olive cultivation is of great importance in Southern Europe but olive pollen is the leading cause of allergy in many regions where it is grown. The best preventive measure for allergic patients is to avoid exposure. Thus, aerobiological monitoring networks must supply realistic pollen classes for the different types of allergic pollen. Even though those pollen classes are defined, they do not necessarily fit local data. Altogether, they should use predictive models to assess flowering intensity in advance. In this study, the Olea pollen degree of exposure classes (OPDEC) are defined based on percentiles and a predictive model is suggested for Cartagena, Spain...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29181536/pharmacologic-treatment-of-seasonal-allergic-rhinitis-synopsis-of-guidance-from-the-2017-joint-task-force-on-practice-parameters
#20
Dana V Wallace, Mark S Dykewicz, John Oppenheimer, Jay M Portnoy, David M Lang
Description: The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older. Methods: To update a prior systematic review, the workgroup searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 18 July 2012 to 29 July 2016 to identify studies that addressed efficacy and adverse effects of single or combination pharmacotherapy for seasonal allergic rhinitis...
November 28, 2017: Annals of Internal Medicine
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