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https://www.readbyqxmd.com/read/29902173/effect-of-tomato-variety-cultivation-climate-and-processing-on-sola-l-4-an-allergen-from-solanum-lycopersicum
#1
Elisabeth Kurze, Roberto Lo Scalzo, Gabriele Campanelli, Wilfried Schwab
Tomatoes (Solanum lycopersicum) are one of the most consumed vegetables worldwide. However, tomato allergies in patients suffering from birch pollen allergy occur frequently. Due to highly similar protein structures of the tomato allergen Sola l 4 and the major birch pollen allergen Bet v 1, patients cross-react with allergenic proteins from tomato as well as other fruits or vegetables. The aim of this study was to quantify Sola l 4 in various tomatoes differing in color, size and shape for identification of varieties with a reduced allergen level...
2018: PloS One
https://www.readbyqxmd.com/read/29890615/respiratory-condition-of-family-farmers-exposed-to-pesticides-in-the-state-of-rio-de-janeiro-brazil
#2
Rafael J Buralli, Helena Ribeiro, Thais Mauad, Luís F Amato-Lourenço, João M Salge, Fredi A Diaz-Quijano, Renata S Leão, Rejane C Marques, Daniele S Silva, Jean Remy Davée Guimarães
Pesticide exposure is a growing public health concern. Although Brazil is the world’s largest consumer of pesticides, only a few studies have addressed the health effects among farmers. This study aimed to evaluate whether pesticide exposure is associated with respiratory outcomes among rural workers and relatives in Brazil during the crop and off-seasons. Family farmers (82) were interviewed about occupational history and respiratory symptoms, and cholinesterase tests were conducted in the crop-season...
June 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29884969/ace-inhibitor-induced-angioedema-a-review
#3
REVIEW
William J Kostis, Mrinali Shetty, Yuvraj Singh Chowdhury, John B Kostis
PURPOSE OF REVIEW: This study aims to examine current knowledge on the occurrence, pathophysiology, and treatment of angioedema among patients who receive angiotensin-converting enzyme inhibitors. RECENT FINDINGS: Angiotensin-converting enzyme inhibitors (ACE-I), a medication class used by an estimated 40 million people worldwide, are associated with angioedema that occurs with incidence ranging from 0.1 to 0.7%. The widespread use of ACE-I resulted in one third of all emergency department visits for angioedema...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29872601/serotonin-syndrome-presenting-with-concomitant-tramadol-and-diphenhydramine-use-a-case-report-of-an-unlikely-side-effect
#4
Salman Khan, Shakir Saud, Imran Khan, Muhammad Asif, Osama Ismail, Arqam Salam, Tsu Jung Yang, Kim J Norville
Serotonin syndrome is a condition that occurs following the administration of serotonergic drugs. Interestingly, on rare occasions, it can occur with various drug combinations that can secondarily affect the serum levels of 5-hydroxytryptamin. Tramadol is an analgesic that has mu opioid receptor agonist activity and has also been shown to inhibit the reuptake of serotonin and noradrenaline. Diphenhydramine is a first-generation histamine antagonist prescribed to treat or prevent allergic reactions and can also be used as a sleeping aid...
April 4, 2018: Curēus
https://www.readbyqxmd.com/read/29798395/-an-analysis-of-spectrum-of-allergen-sensitization-among-patients-with-tree-pollen-allergy-in-beijing
#5
X Y Wang, H Y Ning, S M Chu, L Jiang, Y J Pang, W T Jin, S Q Wang, X Y Wang
Objective: To explore the feature of allergic sensitization of tree pollen and the relationship between tree pollen and airborne pollen in Beijing. Method: Two thousand five hundred and twenty-one patients with allergic diseases were enrolled between January to July in 2017 in an allergy department. All patients received SPT of 8 kinds of tree pollen. Result: ①The overall tree pollen positive rate of SPT was 49.3% (1 244/2 521). Male had a higher positive rate than female (56.4% vs 45.0%, P <0.01) while child group had a higher positive rate than adult group (55...
December 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29791010/new-eaaci-definition-on-pollen-season-mirrors-symptom-load-for-grass-and-birch-pollen-induced-allergic-rhinitis
#6
Kostas Karatzas, Nikos Katsifarakis, Marina Riga, Barbora Werchan, Matthias Werchan, Uwe Berger, Oliver Pfaar, Karl-Christian Bergmann
BACKGROUND: The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergens exposure time-periods. We evaluate pollen data from Germany to examine the new definitions on pollen season and peak pollen period start and end as proposed by the European Academy of Allergy and Clinical Immunology (EAACI) in a recently published Position Paper. The aim was to demonstrate the ability of these definitions to mirror symptom loads for grass and birch pollen-induced allergic rhinitis based on real-life data...
May 23, 2018: Allergy
https://www.readbyqxmd.com/read/29782182/a-specifically-designed-multispecies-probiotic-supplement-relieves-seasonal-allergic-rhinitis-symptoms
#7
Annabelle M Watts, Amanda J Cox, Peter K Smith, Isolde Besseling-van der Vaart, Allan W Cripps, Nicholas P West
BACKGROUND: Probiotics are purported to reduce symptoms of allergic rhinitis. This study sought to determine the proportion of participants with an improvement in the mini Rhinoconjunctivitis Quality of Life Questionnaire (mRQLQ) in response to a multispecies probiotic supplement with a Simon Two-Stage design. METHODS: This study was based on a Simon Two-Stage Design for p1 -p0  = 0.18 to account for seasonal variation in symptoms. Under this design, ≥10 patients are required to exhibit an improvement in quality-of-life scores to determine that there was sufficient activity for the supplement to be considered effective...
May 21, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29771037/-association-between-airborne-pollen-distribution-and-allergic-diseases-in-beijing-urban-area
#8
X Y Wang, Z M Tian, H Y Ning, X Y Wang
Objective: The aim of this study is to investigate the impact of airborne pollen in urban Beijing area on the consultation rate of allergic diseases. Method: A modified pollen sampler was used to monitor the distribution of main airborne pollen during Jan 1st 2015 to Dec 31 2015.The consultation rate of allergic rhinitis and asthma was obtained meanwhile among allergy, ENT and pneumology department. Relationship between pollen and consultation rate was analyzed by Pearson index. Result: ①Through the whole year of 2015 the total quantity of pollens amounted to 76164 grains...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770588/trends-in-the-prescribing-of-topical-nasal-agents-using-an-nhs-england-data-base
#9
Haroon Shakeel Saeed, Rosie B Wright, Samit Kumar Ghosh
OBJECTIVES: Our aim is to present data depicting geographical prescribing trends and expenditure related to topical nasal agent prescriptions across clinical commissioning groups (CCG's) in England. We assess if prescribing trends can act as a surrogate marker for allergic rhinitis (AR) and rhinosinusitis disease burden (RS). DESIGN: NHS England primary care prescriptions dispensed for topical drugs used in nasal allergy (BNF chapter 12.2.1) were accessed using OpenPrescribing beta software...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29759659/the-global-development-and-clinical-efficacy-of-sublingual-tablet-immunotherapy-for-allergic-diseases
#10
REVIEW
Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies...
May 12, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29742519/differences-in-reporting-the-ragweed-pollen-season-using-google-trends-across-15-countries
#11
Jean Bousquet, Ioana Agache, Uwe Berger, Karl-Christian Bergmann, Jean-Pierre Besancenot, Philippe J Bousquet, Tom Casale, Gennaro d'Amato, Igor Kaidashev, Musa Khaitov, Ralph Mösges, Kristof Nekam, Gabrielle L Onorato, Davor Plavec, Aziz Sheikh, Michel Thibaudon, Robert Vautard, Mihaela Zidarn
BACKGROUND: Google Trends (GT) searches trends of specific queries in Google, which potentially reflect the real-life epidemiology of allergic rhinitis. We compared GT terms related to ragweed pollen allergy in American and European Union countries with a known ragweed pollen season. Our aim was to assess seasonality and the terms needed to perform the GT searches and to compare these during the spring and summer pollen seasons. METHODS: We examined GT queries from January 1, 2011, to January 4, 2017...
May 9, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29714566/clinical-trial-results-summary-for-laypersons-a-user-testing-study
#12
D K Raynor, L Myers, K Blackwell, B Kress, A Dubost, A Joos
OBJECTIVE: To apply "user testing" to maximize readability and acceptability of a Clinical Trial Results Laypersons Summary-a new European requirement. METHODS: "User testing" (using questionnaire and semistructured interview) assessed whether people could find and understand key points. Findings were used to improve content and design, prior to retesting. Participants had a range of levels of health literacy and there was a higher education group...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#13
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29667465/association-of-serum-specific-ige-levels-with-asthma-in-autumn-pollen-induced-allergic-rhinitis-a-retrospective-analysis
#14
Le Cui Md, Jia Yin Md
BACKGROUND: Artemisia and Humulus pollen are the two most important aeroallergens of autumn allergies in North China. Cross-sectional data in 2001 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients with autumn pollinosis in North China. OBJECTIVE: We used this cross-sectional data to investigate the association of serum specific IgE (sIgE) levels to Humulus and/or Artemisia pollen with the onset of asthma in patients with autumn pollen-induced allergic rhinitis...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29649224/seasonal-asthma-in-melbourne-australia-and-some-observations-on-the-occurrence-of-thunderstorm-asthma-and-its-predictability
#15
Jeremy D Silver, Michael F Sutherland, Fay H Johnston, Edwin R Lampugnani, Michael A McCarthy, Stephanie J Jacobs, Alexandre B Pezza, Edward J Newbigin
We examine the seasonality of asthma-related hospital admissions in Melbourne, Australia, in particular the contribution and predictability of episodic thunderstorm asthma. Using a time-series ecological approach based on asthma admissions to Melbourne metropolitan hospitals, we identified seasonal peaks in asthma admissions that were centred in late February, June and mid-November. These peaks were most likely due to the return to school, winter viral infections and seasonal allergies, respectively. We performed non-linear statistical regression to predict daily admission rates as functions of the seasonal cycle, weather conditions, reported thunderstorms, pollen counts and air quality...
2018: PloS One
https://www.readbyqxmd.com/read/29620294/-seasonal-allergic-rhinitis
#16
Igor Salvadé, Laura Moi, Camillo Ribi, François Spertini
Allergic diseases are currently amongst the most frequent diseases of our time. Of all the allergies in the Western countries, allergic rhinoconjunctivitis is the most common. Its diagnosis is based mainly on the history and the correlation between symptoms and contact with the allergen. A step-by-step approach helps optimize diagnostic resources and minimize costs.
April 4, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29603916/phase-1-pharmacokinetics-and-phase-3-efficacy-of-testosterone-nasal-gel-in-subjects-with-seasonal-allergies
#17
Alan D Rogol, Natalia Tkachenko, Philipp Badorrek, Jens M Hohlfeld, Nathan Bryson
INTRODUCTION: NATESTO® testosterone nasal gel (TNG) is a liquid gel that is applied in the nose for the treatment of male hypogonadism. There is a reasonable concern that administration of TNG to patients with active rhinitis could modify absorption. Results from two clinical studies are reported wherein subjects with allergic rhinitis (AR) subjects are treated with TNG. METHODS: The 24-hour pharmacokinetics (PK) and relative bioavailability of serum total testosterone (sTT) from TNG (11 mg tid ) were determined using a phase 1 Latin-square design with 18 eugonadal AR subjects crossed over between asymptomatic, symptomatic-untreated, and symptomatic-treated (oxymetazoline) conditions...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29577619/cellular-and-molecular-mechanisms-of-vitamin-d-in-food-allergy
#18
REVIEW
Ashlyn Poole, Yong Song, Helen Brown, Prue H Hart, Guicheng Brad Zhang
Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29574559/how-do-storms-affect-asthma
#19
REVIEW
Gennaro D'Amato, Isabella Annesi-Maesano, Adriano Vaghi, Lorenzo Cecchi, Maria D'Amato
PURPOSE OF REVIEW: There are observations in various geographical areas that thunderstorms occurring during pollen seasons can induce severe asthma attacks in pollinosis patients. RECENT FINDINGS: An accredited hypothesis explaining the association between thunderstorms and asthma suggests that storms can concentrate pollen grains at ground level, which may then release allergenic particles of respirable size in the atmosphere after their imbibition of water and rupture by osmotic shock...
March 24, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29551533/immunotherapy-with-the-sq-tree-slit-tablet-in-adults-and-adolescents-with-allergic-rhinoconjunctivitis
#20
Mika J Mäkelä, Pär Gyllfors, Erkka Valovirta, Maria A Steffensen, Pernille M Grønager, Johannes Savolainen, Lone Winther
PURPOSE: The SQ tree sublingual immunotherapy (SLIT)-tablet containing allergen extracts with the major allergen Bet v 1 from birch pollen is currently being developed for the treatment of tree pollen-induced allergic rhinitis/conjunctivitis with or without asthma. The aim of this Phase II trial was to investigate the dose-related efficacy and safety of the SQ tree SLIT-tablet. METHODS: This study was a randomized, parallel-group, double-blind, placebo-controlled, multi-national trial conducted in Europe...
April 2018: Clinical Therapeutics
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