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https://www.readbyqxmd.com/read/28326908/sublingual-immunotherapy-tablets-as-a-disease-modifying-add-on-treatment-option-to-pharmacotherapy-for-allergic-rhinitis-and-asthma
#1
Stephen Brunton, Harold S Nelson, David I Bernstein, Simon Lawton, Susan Lu, Hendrik Nolte
Allergic rhinitis (AR) with or without conjunctivitis (AR/C) is associated with a significant health and economic burden, and is often accompanied by asthma. Pharmacotherapies are the mainstay treatment options for AR and asthma, but guidelines also recommend allergy immunotherapy (AIT). Unlike pharmacotherapies, AIT has the ability to modify the underlying immunologic mechanisms of AR and asthma with the potential for long-term benefits after treatment is discontinued. Immunotherapy may also prevent progression of AR/C to asthma...
March 22, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28294587/vitamin-d-levels-and-allergic-diseases-an-italian-cross-sectional-multicenter-survey
#2
C Lombardi, G Passalacqua
Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28286602/climate-change-allergy-and-asthma-and-the-role-of-tropical-forests
#3
REVIEW
Gennaro D'Amato, Carolina Vitale, Nelson Rosario, Herberto Josè Chong Neto, Deborah Carla Chong-Silva, Francisco Mendonça, Josè Perini, Loraine Landgraf, Dirceu Solé, Mario Sánchez-Borges, Ignacio Ansotegui, Maria D'Amato
BACKGROUND: Tropical forests cover less than 10 per cent of all land area (1.8 × 107 km(2)) and over half of the tropical-forest area (1.1 × 107 Km(2)) is represented by humid tropical forests (also called tropical rainforests). The Amazon basin contains the largest rainforest on Earth, almost 5.8 million km(2), and occupies about 40% of South America; more than 60% of the basin is located in Brazil and the rest in Bolivia, Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname and Venezuela...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28286421/pharmacoeconomics-of-sublingual-immunotherapy-with-the-5-grass-pollen-tablets-for-seasonal-allergic-rhinitis
#4
REVIEW
Carlo Lombardi, Valerie Melli, Cristoforo Incorvaia, Erminia Ridolo
Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This particularly concerns allergen immunotherapy (AIT), that, based on its immunological action on the causes of allergy, extends its benefit also after discontinuation of the treatment. From the pharmacoeconomic point of view, any treatment must be evaluated according to its cost-effectiveness, that is, the ratio between the cost of the intervention and its effect...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28280371/evaluation-of-a-sublingual-immunotherapy-solution-in-olive-induced-respiratory-allergy-in-jordan-a-retrospective-observational-study
#5
Khaled Al-Asad, Sayed Al-Nazer, Anan Al-Faqih, Mohammad Jamil Hashem
BACKGROUND: Olive pollen is an important cause of respiratory allergy in the Middle East. In this study, the clinical characteristics of adults and children with confirmed allergic rhinitis (AR; with or without asthma) in Jordan were described, and the use of sublingual immunotherapy (SLIT) in a real-life clinical setting was assessed. METHODS: This retrospective observational study evaluated the clinical features of olive-induced allergy and the use of an SLIT solution of standardized extracts toward Ole e 1 given in a pre- and coseasonal scheme with a daily dose of 300 index of reactivity for two consecutive seasons...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28274229/exposure-to-phthalates-and-bisphenol-a-are-associated-with-atopic-dermatitis-symptoms-in-children-a-time-series-analysis
#6
Eun-Hye Kim, Byoung-Hak Jeon, Jihyun Kim, Young-Min Kim, Youngshin Han, Kangmo Ahn, Hae-Kwan Cheong
BACKGROUND: Despite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. METHODS: We surveyed 18 boys with AD (age 3-7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary...
March 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28270216/bifidobacterium-mixture-b-longum-bb536-b-infantis-m-63-b-breve-m-16v-treatment-in-children-with-seasonal-allergic-rhinitis-and-intermittent-asthma
#7
Michele Miraglia Del Giudice, Cristiana Indolfi, Michele Capasso, Nunzia Maiello, Fabio Decimo, Giorgio Ciprandi
BACKGROUND: Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating whether a Bifidobacteria mixture could be able to relieve nasal symptoms, and affect quality of life (QoL) in children with AR and intermittent asthma due to Parietaria allergy. MATERIALS AND METHODS: The present study was conducted as placebo-controlled, double-blinded, and randomized...
March 7, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28236796/cost-effectiveness-of-a-protocol-using-palivizumab-in-preterm-infants
#8
Yolanda Hernández-Gago, Marina Lombardero-Pin, Casilda Ortega de la Cruz, Pablo A Maciuniak, Alicia Díez Del Pino
OBJECTIVE: The main objective was to evaluate the cost-effectiveness of protocol use of palivizumab in premature established by consensus in our Hospital comparing it based on the recommendations of various Scientific Societies. As a secondary objective risk factors and severity of hospitalized patients attending the established protocol in our Hospital were analyzed. METHODS: The study period was 4 seasons with the expanded protocol (retrospective data) versus 2 with restricted or agreed protocol (prospective data)...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28236469/treatment-with-grass-allergen-peptides-improves-symptoms-of-grass-pollen-induced-allergic-rhinoconjunctivitis
#9
Anne K Ellis, Charles W Frankish, Robyn E O'Hehir, Kristen Armstrong, Lisa Steacy, Mark Larché, Roderick P Hafner
BACKGROUND: Synthetic peptide immunoregulatory epitopes are a new class of immunotherapy to treat allergic rhinoconjunctivitis (ARC). Grass allergen peptides, comprising 7 synthetic T-cell epitopes derived from Cyn d 1, Lol p 5, Dac g 5, Hol l 5, and Phl p 5, is investigated for treatment of grass pollen-induced ARC. OBJECTIVE: We sought to evaluate the efficacy, safety, and tolerability of intradermally administered grass allergen peptides. METHODS: A multicenter, randomized, double-blind, placebo-controlled study evaluated 3 regimens of grass allergen peptides versus placebo in patients with grass pollen-induced allergy (18-65 years)...
February 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28228426/probiotics-lactobacillus-gasseri-ks-13-bifidobacterium-bifidum-g9-1-and-bifidobacterium-longum-mm-2-improve-rhinoconjunctivitis-specific-quality-of-life-in-individuals-with-seasonal-allergies-a-double-blind-placebo-controlled-randomized-trial
#10
Jennifer C Dennis-Wall, Tyler Culpepper, Carmelo Nieves, Cassie C Rowe, Alyssa M Burns, Carley T Rusch, Ashton Federico, Maria Ukhanova, Sheldon Waugh, Volker Mai, Mary C Christman, Bobbi Langkamp-Henken
Background: Rhinoconjunctivitis-specific quality of life is often reduced during seasonal allergies. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (MRQLQ) is a validated tool used to measure quality of life in people experiencing allergies (0 = not troubled to 6 = extremely troubled). Probiotics may improve quality of life during allergy season by increasing the percentage of regulatory T cells (Tregs) and inducing tolerance.Objective: The objective of this study was to determine whether consuming Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and B...
March 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28182031/allergies-in-urban-versus-countryside-settings-in-poland-as-part-of-the-epidemiology-of-the-allergic-diseases-in-poland-ecap-study-challenge-the-early-differential-diagnosis
#11
Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Aneta Tomaszewska, Adam Sybilski, Bolesław K Samoliński
INTRODUCTION: The incidence of allergies depends on a number of factors, including adopting an urban "western" lifestyle, genetic predispositions, and different regions of residence. AIM: To compare the prevalence of allergic conditions (seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR), bronchial asthma (BA), atopic dermatitis (AD)) in a group of countryside versus urban residents in Poland. MATERIAL AND METHODS: The prevalence of allergic conditions in urban versus countryside settings was assessed using the translated and approved questionnaire developed for international ECRHS II and ISAAC studies...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28140507/google-trends-terms-reporting-rhinitis-and-related-topics-differ-in-european-countries
#12
Jean Bousquet, Ioana Agache, Josep M Anto, Karl C Bergmann, Claus Bachert, Isabella Annesi-Maesano, Philippe J Bousquet, Gennaro D'Amato, Pascal Demoly, Govert De Vries, Esben Eller, Wytske Fokkens, Joao Fonseca, Tari Haahtela, Peter W Hellings, Jocelyne Just, Thomas Keil, Ludger Klimek, Piotr Kuna, Karin C Lodrup Carlsen, Ralf Mösges, Ruth Murray, Kristof Nekam, Gabrielle Onorato, Nikos G Papadopoulos, Boleslaw Samolinski, Peter Schmid-Grendelmeier, Michel Thibaudon, Peter Tomazic, Massimo Triggiani, Arunas Valiulis, Erkka Valovirta, Michiel Van Eerd, Magnus Wickman, Torsten Zuberbier, Aziz Sheikh
Google Trends (GT) searches trends of specific queries in Google and reflects the real-life epidemiology of allergic rhinitis. We compared Google Trends terms related to allergy and rhinitis in all European Union countries, Norway and Switzerland from January 1, 2011 to December 20, 2016. The aim was to assess whether the same terms could be used to report the seasonal variations of allergic diseases. Using the Google Trend 5-year graph, an annual and clear seasonality of queries was found in all countries apart from Cyprus, Estonia, Latvia, Lithuania and Malta...
January 31, 2017: Allergy
https://www.readbyqxmd.com/read/28129069/placement-and-format-of-risk-information-on-direct-to-consumer-prescription-drug-websites
#13
Helen W Sullivan, Amie C O'Donoghue, Douglas J Rupert, Jessica Fitts Willoughby, Kathryn J Aikin
We investigated whether the location and format of risk information on branded prescription drug websites influence consumers' knowledge and perceptions of the drug's risks. Participants (Internet panelists with high cholesterol [n = 2,609] or seasonal allergies [n = 2,637]) were randomly assigned to view a website promoting a fictitious prescription drug for their condition. The website presented risk information at the bottom of the homepage, or at the bottom of the homepage with a signal above indicating that the risk information was located below, or on a linked secondary page...
January 27, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28124640/local-allergic-rhinitis-to-pollens-is-underdiagnosed-in-young-patients
#14
Anna Krajewska-Wojtys, Jerzy Jarzab, Radoslaw Gawlik, Andrzej Bozek
BACKGROUND: Local allergic rhinitis (LAR) has been observed in patients without atopy. However, LAR is still underdiagnosed in patients with perennial or seasonal nasal symptoms. OBJECTIVE: The aim of this study was to determine the prevalence of LAR in young patients with a previous diagnosis of nonallergic rhinitis or suspicion of allergy. METHODS: A total of 121 patients, ages 12-18 years old, with confirmed nonallergic rhinitis and typical seasonal nasal symptoms were examined...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28122395/memory-and-multitasking-performance-during-acute-allergic-inflammation-in-seasonal-allergic-rhinitis
#15
Katharina Trikojat, Angelika Buske-Kirschbaum, Franziska Plessow, Jochen Schmitt, Rico Fischer
BACKGROUND: In previous research patients with seasonal allergic rhinitis (SAR) showed poorer school and work performance during periods of acute allergic inflammation, supporting the idea of an impact of SAR on cognitive functions. However, the specific cognitive domains particularly vulnerable to inflammatory processes are unclear. OBJECTIVE: In the present study the influence of SAR on memory and multitasking performance, as two potentially vulnerable cognitive domains essential in everyday life functioning, was investigated in SAR patients...
January 25, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28121438/rna-seq-analysis-of-developing-pecan-carya-illinoinensis-embryos-reveals-parallel-expression-patterns-among-allergen-and-lipid-metabolism-genes
#16
Christopher P Mattison, Ruhi Rai, Robert E Settlage, Doug J Hinchliffe, Crista Madison, John M Bland, Suzanne Brashear, Charles J Graham, Matthew R Tarver, Christopher Florane, Peter J Bechtel
The pecan nut is a nutrient-rich part of a healthy diet full of beneficial fatty acids and antioxidants, but can also cause allergic reactions in people suffering from food allergy to the nuts. The transcriptome of a developing pecan nut was characterized to identify the gene expression occurring during the process of nut development and to highlight those genes involved in fatty acid metabolism and those that commonly act as food allergens. Pecan samples were collected at several time points during the embryo development process including the water, gel, dough, and mature nut stages...
February 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28120599/parietaria-pollination-duration-myth-or-fact
#17
R Ariano, L Cecchi, S Voltolini, O Quercia, E Scopano, G Ciprandi
Background. Even though the Parietaria pollen season may be rather long, it is commonly thought that Parietaria pollen is a perennial allergen present along the whole year. Objective. This study aimed at investigating the duration of Parietaria pollen season during a 10-year period in Italy, analysing also the annual pollen quantity and the differences among geographical areas. Methods. Pollen count was assessed daily for 10 years. Globally, ten Italian centers measured Parietaria pollen count. Start date, peak date, end date, duration (days), peak value, and seasonal pollen index were evaluated in each center...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28096738/clinical-management-expectations-and-satisfaction-of-patients-with-moderate-to-severe-allergic-rhinoconjunctivitis-treated-with-sq-standardized-grass-allergen-tablet-under-routine-clinical-practice-conditions-in-spain
#18
Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral, Carlos Puerto, Joan Serra-Batllés, Adolfo Vélez, Jonathan Vicente, Fernando de la Torre
BACKGROUND: Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX(®) is the most documented product in terms of safety and efficacy. The objective of this study was to identify the patients' expectations and level of treatment satisfaction, as well as the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX(®). METHODS: This was a non-interventional, observational, multi-centre, open-label study involving a total of 131 adult patients aged 18-66 years with confirmed diagnosis of grass-allergy and initiated treatment with GRAZAX(®) between June 2010 and April 2011...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28041857/immunoproteomics-of-tree-of-heaven-ailanthus-atltissima-pollen-allergens
#19
Fateme Mousavi, Ahmad Majd, Youcef Shahali, Farrokh Ghahremaninejad, Raheleh Shokouhi Shoormasti, Zahra Pourpak
Ailanthus altissima pollen (AAP) is considered as an emerging cause of respiratory allergy in United States, Italy and Iran. However, the allergenic composition of AAP is still unknown and has yet to be characterized. The present study aimed to identify AAP allergens using a proteomics-based approach. For this purpose, optimized AAP protein extracts were analyzed using 1D- and 2D- gel electrophoresis and confronted to twenty sera from individuals with respiratory allergy during the AAP season. Candidate allergens were detected using the serum from an allergic patient with clinical history of AAP pollinosis...
February 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28030920/sandpits-as-a-reservoir-of-potentially-pathogenic-fungi-for-children
#20
Anna Wójcik, Joanna Błaszkowska, Piotr Kurnatowski, Katarzyna Góralska
INTRODUCTION AND OBJECTIVE: Fungi belonging to various physiological and morphological groups present in the environment are potential human pathogens. Some of them are considered as emerging pathogens. Therefore, their presence in children's playgrounds should be regarded as health risk factor. MATERIALS AND METHOD: Sixty-eight samples of sand collected from 17 sandpits of different localities in Łódź, Poland, in autumn 2010 and 2011, and in spring 2011 and 2012 were evaluated...
December 23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
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