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https://www.readbyqxmd.com/read/28078662/low-immunoglobulin-e-flags-two-distinct-types-of-immune-dysregulation
#1
M Elkuch, V Greiff, C T Berger, M Bouchenaki, T Daikeler, A Bircher, A A Navarini, I Heijnen, M Recher
During the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a single-centre out-patient immunodeficiency and allergy clinic...
January 11, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28077477/the-global-asthma-network-rationale-and-methods-for-phase-i-global-surveillance-prevalence-severity-management-and-risk-factors
#2
Philippa Ellwood, M Innes Asher, Nils E Billo, Karen Bissell, Chen-Yuan Chiang, Eamon M Ellwood, Asma El-Sony, Luis García-Marcos, Javier Mallol, Guy B Marks, Neil E Pearce, David P Strachan
The Global Asthma Network (GAN), established in 2012, followed the International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Phase One involved over 700 000 adolescents and children from 156 centres in 56 countries; it found marked worldwide variation in symptom prevalence of asthma, rhinitis and eczema that was not explained by the current understanding of these diseases; ISAAC Phase Three involved over 1 187 496 adolescents and children (237 centres in 98 countries). It found that asthma symptom prevalence was increasing in many locations especially in low- and middle-income countries where severity was also high, and identified several environmental factors that required further investigation...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28069072/pansaid-paracetamol-and-nsaid-in-combination-study-protocol-for-a-randomised-trial
#3
Kasper Højgaard Thybo, Daniel Hägi-Pedersen, Jørn Wetterslev, Jørgen Berg Dahl, Henrik Morville Schrøder, Hans Henrik Bülow, Jan Gottfrid Bjørck, Ole Mathiesen
BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. No 'gold standard' exists after total hip arthroplasty (THA) and combinations of different nonopioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy. The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen alone and in combination in different dosages after THA. METHODS: PANSAID is a placebo-controlled, parallel four-group, multicentre trial with centralised computer-generated allocation sequence and allocation concealment and with varying block size and stratification by site...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28065802/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#4
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
December 30, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28065278/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#5
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28062882/anaphylaxis-in-children-experience-of-485-episodes-in-1-272-482-patient-attendances-at-a-tertiary-paediatric-emergency-department-from-2007-to-2014
#6
Sashikumar Ganapathy, Zaw Lwin, Daniel Ha Ting, Lynette Sh Goh, Shu Ling Chong
Introduction: Anaphylaxis is a predominantly childhood disease. Most of the literature on anaphylaxis has emerged from Western countries. This study aimed to describe the incidence, triggers and clinical presentation of anaphylaxis among children in Singapore, look for predictors for anaphylaxis with severe outcomes, and study the incidence of biphasic reactions. Materials and Methods: We retrospectively reviewed records of children presenting with anaphylaxis to our paediatric emergency department from 1 January 2007 to 31 December 2014...
December 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28058751/allergen-immunotherapy-for-ige-mediated-food-allergy-a-systematic-review-and-meta-analysis
#7
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars K Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. METHODS: We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and non-randomized studies (NRS)...
January 6, 2017: Allergy
https://www.readbyqxmd.com/read/28054723/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#8
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28052801/factors-that-determine-parents-perception-of-their-child-s-risk-of-life-threatening-food-induced-anaphylaxis
#9
Jennifer Ogg, Jayne Wong, Ming Wai Wan, Naomi Davis, Peter D Arkwright
BACKGROUND: Although food allergy is known to be associated with increased disease burden, factors that shape parents' perception of their child's risk of future severe or fatal anaphylaxis are poorly understood. OBJECTIVE: This study aimed to evaluate factors associated with parents' perceived risk of food-induced anaphylaxis. METHODS: A questionnaire-based survey of 202 parents was conducted in a single specialist center outpatient clinic that treats children with food allergies...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28045938/exposure-to-indoor-allergens-in-different-residential-settings-and-its-influence-on-ige-sensitization-in-a-geographically-confined-austrian-cohort
#10
Teresa Stemeseder, Bettina Schweidler, Patrick Doppler, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Martin Himly, Roland Lang, Joerg Zumbach, Gertie J Oostingh, Thomas Hawranek, Arne C Bathke, Gabriele Gadermaier
BACKGROUND: Exposure to indoor allergens is crucial for IgE sensitization and development of allergic symptoms. Residential settings influence the allergen amount in house dust and hence allergic sensitization. Within this study, we investigated allergen exposure and molecule-based IgE levels in a geographically confined region and evaluated the impact of housing, pets and cleaning. METHODS: 501 adolescents from Salzburg, Austria participated in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28045551/use-of-a-low-literacy-written-action-plan-to-improve-parent-understanding-of-pediatric-asthma-management-a-randomized-controlled-study
#11
Hsiang Shonna Yin, Ruchi Gupta, Alan L Mendelsohn, Benard P Dreyer, Linda van Schaick, Christina R Brown, Karen Encalada, Dayana Sanchez, Christopher Warren, Suzy Tomopoulos
OBJECTIVES: To determine whether parents who use a low literacy, pictogram- and photograph-based written asthma action plan have a better understanding of child asthma management compared to parents using a standard plan. METHODS: Randomized controlled study in 2 urban pediatric outpatient clinics. INCLUSION CRITERIA: English/Spanish-speaking parents of 2-12 year old asthmatic children. Parents were randomized to receive a low literacy or standard asthma action plan (American Academy of Allergy, Asthma and Immunology) for a hypothetical patient on controller and rescue medications...
January 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28043850/allergies-in-orthopaedic-and-trauma-surgery
#12
REVIEW
C H Lohmann, R Hameister, G Singh
Hypersensitivity reactions to implants in orthopaedic and trauma surgery are a rare but devastating complication. They are considered as a delayed-type of hypersensitivity reaction (type IV), characterized by an antigen activation of sensitized T-lymphocytes releasing various cytokines and may result in osteoclast activation and bone resorption. Potential haptens are originated from metal alloys or bone-cement. A meta-analysis has confirmed a higher probability of developing a metal hypersensitivity postoperatively and noted a greater risk of failed replacements compared to stable implants...
December 30, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#13
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28042003/the-prevalence-of-eosinophilic-esophagitis-in-pediatric-patients-with-ige-mediated-food-allergy
#14
David A Hill, Jesse W Dudley, Jonathan M Spergel
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association. OBJECTIVE: We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE. METHODS: Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy...
December 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28039077/pharmacokinetics-of-tiotropium-administered-by-respimat-%C3%A2-in-asthma-patients-analysis-of-pooled-data-from-phase-ii-and-iii-clinical-trials
#15
Ashish Sharma, Huib A M Kerstjens, René Aalbers, Petra Moroni-Zentgraf, Benjamin Weber, Ronald Dahl
Tiotropium is a long-acting inhaled antimuscarinic bronchodilator that has recently received marketing authorization for the indication of asthma with dose delivery via the Respimat(®) inhaler, in addition to its widely established role in the management of chronic obstructive pulmonary disease (COPD). This report presents a combined analysis of tiotropium plasma and urine pharmacokinetics at steady state from 8 Phase II/III clinical trials in asthma and delineates the effects of patient characteristics on systemic exposure based on the parameters fe0-24,ss (fraction of dose excreted unchanged in urine over 24 h post-dose at steady-state) and dose-normalized AUCtau,ss and Cmax,ss...
December 27, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28035215/the-role-and-choice-criteria-of-antihistamines-in-allergy-management-expert-opinion
#16
Piotr Kuna, Dariusz Jurkiewicz, Magdalena M Czarnecka-Operacz, Rafał Pawliczak, Jarosław Woroń, Marcin Moniuszko, Andrzej Emeryk
Allergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28034549/basophil-activation-test-is-a-relevant-biomarker-of-the-outcome-of-rapid-desensitization-in-platinum-compounds-allergy
#17
Pedro Giavina-Bianchi, Violeta Régnier Galvão, Matthieu Picard, Joana Caiado, Mariana C Castells
BACKGROUND: Rapid drug desensitization (RDD) has become a cornerstone in the management of immediate drug hypersensitivity reactions (DHRs) to chemotherapeutic agents. Because of the inherent risk of anaphylaxis during RDD, biomarkers to predict patients at risk of developing such severe reactions are needed. The basophil activation test (BAT) has been used in DHRs as a diagnostic tool. OBJECTIVE: We evaluated basophil CD63 and CD203c expression (BAT) as a biomarker to assess the safety and effectiveness of RDD in platinum compounds-allergic patients...
December 26, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28033731/real-life-clinical-practice-and-management-of-polysensitized-patients-with-respiratory-allergies-a-large-global-survey-of-clinicians-prescribing-allergen-immunotherapy
#18
Ulrich Wahn, Moises A Calderon, Pascal Demoly
BACKGROUND: The allermix survey was conducted to gain insights into the most frequently diagnosed allergies worldwide, the use of allergen immunotherapy (AIT) in clinical practice, and to identify current clinical approaches for the management of polyallergic patients. METHODS: The survey was conducted in 19 countries worldwide during 2016. Clinicians currently prescribing AIT completed an online questionnaire, designed to gather data on their daily clinical practice, most commonly diagnosed and treated allergies among their patients, awareness and adherence to recommendations and guidelines on AIT, the AIT format(s) that they choose to prescribe, and management of polyallergic patients...
December 29, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28032353/allergooncology-the-impact-of-allergy-in-oncology-eaaci-position-paper
#19
E Jensen-Jarolim, H J Bax, R Bianchini, M Capron, C Corrigan, M Castells, D Dombrowicz, T R Daniels-Wells, J Fazekas, E Fiebiger, S Gatault, H J Gould, J Janda, D H Josephs, P Karagiannis, F Levi-Schaffer, A Meshcheryakova, D Mechtcheriakova, Y Mekori, F Mungenast, E A Nigro, M L Penichet, F Redegeld, L Saul, J Singer, J F Spicer, A G Siccardi, E Spillner, M C Turner, E Untersmayr, L Vangelista, S N Karagiannis
Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both anti-tumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments...
December 29, 2016: Allergy
https://www.readbyqxmd.com/read/28029408/gut-microbiota-and-allergy-asthma-from-pathogenesis-to-new-therapeutic-strategies
#20
REVIEW
Y B Kang, Y Cai, H Zhang
Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are among the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of gut microbiota composition. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. Although still a relatively nascent field of research, evidence to date suggests that the gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature...
October 28, 2016: Allergologia et Immunopathologia
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