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REVIEW
Danielle Sansonetti, Jennifer Fleming, Freyr Patterson, Natasha A Lannin, Joan Toglia
PURPOSE: Self-awareness is a multifaceted phenomenon that comprises two main concepts: general awareness and online awareness. The latter is an emerging concept that requires further consensus on its definition. The aim of this paper is to define the key components of online awareness and identify approaches for measuring this concept for adults with neurological conditions. MATERIALS AND METHODS: Concept analysis using Rodgers' evolutionary method was used to systematically review and summarise relevant literature...
April 10, 2024: Disability and Rehabilitation
#22
JOURNAL ARTICLE
Jie-Qiang Xia, Yang-Fan Cheng, Si-Rui Zhang, Yuan-Zheng Ma, Jia-Jia Fu, Tian-Mi Yang, Ling-Yu Zhang, Jean-Marc Burgunder, Hui-Fang Shang
OBJECTIVES: This study aims to elucidate the role of peripheral inflammation in Huntington's disease (HD) by examining the correlation of peripheral inflammatory markers with clinical manifestations and disease prognosis. METHODS: This investigation involved 92 HD patients and 92 matched healthy controls (HCs). We quantified various peripheral inflammatory markers and calculated their derived metrics including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII)...
2024: Frontiers in Neurology
#23
JOURNAL ARTICLE
Gloria Vaghi, Andrea Morotti, Elisa Maria Piella, Micol Avenali, Daniele Martinelli, Silvano Cristina, Marta Allena, Valentina Grillo, Michele Corrado, Federico Bighiani, Francescantonio Cammarota, Alessandro Antoniazzi, Federica Ferrari, Federico Mazzacane, Anna Cavallini, Anna Pichiecchio, Elisa Rognone, Luca Martinis, Luca Correale, Stefano Filippo Castiglia, Dante Trabassi, Mariano Serrao, Cristina Tassorelli, Roberto De Icco
Stroke affects the interconnection between the nervous and immune systems, leading to a down-regulation of immunity called stroke-induced immunosuppression (SII). The primary aim of this study is to investigate SII role as a predictor of functional, neurological, and motor outcomes in the neurorehabilitation setting (NRB). We conducted a prospective observational study enrolling post-acute stroke patients hospitalized for neurorehabilitation. At NRB admission (T0 ) and discharge (T1 ), we assessed presence of SII (defined by a neutrophil-to-lymphocyte ratio ≥ 5) and we evaluated functional independence (Functional Independence Measure-FIM, Barthel Index-BI), motor performances (Tinetti Score, Hauser Ambulation Index) and neurological impairment (NIHSS)...
April 9, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Tiffany Li, Terry Trinh, Annmarie Bosco, Matthew C Kiernan, David Goldstein, Susanna B Park
BACKGROUND: Decades following the introduction of vincristine as treatment for haematological malignancies, vincristine-induced peripheral neuropathy (VIPN) remains a pervasive, untreatable side-effect. However there remains a gap in understanding the characteristics of VIPN in adults. This study presents a comprehensive phenotyping of VIPN. METHODS: Adult patients (n = 57; age = 59.8 ± 14.6) were assessed cross-sectionally following completion of vincristine (months post treatment = 16...
April 9, 2024: Supportive Care in Cancer
#25
JOURNAL ARTICLE
Giuseppa Maresca, Desirèe Latella, Caterina Formica, Isabella Veneziani, Augusto Ielo, Angelo Quartarone, Rocco Salvatore Calabrò, Maria Cristina De Cola
Background: Spinal cord injury (SCI) is a severe and progressive neurological condition caused by trauma to the nervous system, resulting in lifelong disability and severe comorbidities. This condition imposes serious limitations on everyday life, interfering with patients' social lives and compromising their quality of life, psychological well-being, and daily living activities. Rehabilitation is essential to helping SCI patients gain more independence in their daily routines. Home automation (HA) systems provide personalized support to users, allowing them to manage various aspects of their living environment, promoting independence and well-being...
February 23, 2024: Journal of Clinical Medicine
#26
REVIEW
Claudia-Gabriela Potcovaru, Teodor Salmen, Dragoș Bîgu, Miruna Ioana Săndulescu, Petruța Violeta Filip, Laura Sorina Diaconu, Corina Pop, Ileana Ciobanu, Delia Cinteză, Mihai Berteanu
(1) Background: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a tool designed to measure disability in accordance with the International Classification of Functioning, Disability and Health. Measuring disability is becoming increasingly important due to its high prevalence, which continues to rise. Rehabilitation interventions can reduce disability and enhance functioning. (2) Objective: The present study aims to assess the impact of rehabilitation interventions on reducing disability, as measured by the WHODAS 2...
February 22, 2024: Journal of Clinical Medicine
#27
JOURNAL ARTICLE
Kevin K W Wang, David J Barton, Leah McQuillan, Firas Kobeissy, Guangzheng Cai, Haiyan Xu, Zhihui Yang, Erin Trifilio, John B Williamson, Richard Rubenstein, Claudia S Robertson, Amy K Wagner
Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for these proteins in blood, and interrelationships in the acute and chronic time periods post-TBI have not been established. Our objectives were 1) to characterize acute-to-chronic serum NF-L and pNF-H profiles after moderate-severe TBI, as well as acute cerebrospinal fluid (CSF) levels, 2) to evaluate CSF and serum NF-L and pNF-H associations with each other, and 3) to assess biomarker associations with global patient outcome using both the Glasgow Outcome Scale-Extended (GOS-E) and Disability Rating Scale (DRS)...
April 8, 2024: Journal of Neurotrauma
#28
REVIEW
Sébastien Gionet, Maryse Lord, Vickie Plourde
Attention-deficit hyperactivity disorder (ADHD) is often diagnosed in children and adolescents with epilepsy, but clear clinical guidelines on how to make this diagnosis are still lacking. Without these guidelines, there is no consensus between specialists on how to proceed when assessing children with epilepsy for ADHD, which can negatively impact the quality of care being offered to this population. As a first step toward gaining more specific clinical guidelines, this scoping review was aimed at documenting the tools and procedures used to diagnose ADHD in children and adolescents with epilepsy over time and at determining whether the diagnoses were made in accordance with clinical guidelines and recommendations...
April 8, 2024: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
#29
JOURNAL ARTICLE
Song Zhang, Honglei Jiao
Ischemic stroke remains a major cause of disability and death. Kaempferol (Kae) is a neuroprotective flavonoid compound. Thus, this study aimed to explore the impact of Kae on cerebral infarction. We generated the middle cerebral artery occlusion (MCAO) mouse model to study the effects of Kae on infarction volume and neurological function. The oxygen and glucose deprivation (OGD)/reoxygenation (R) model of neural stem cells (NSCs) was established to study the effects of Kae on cell viability, migration, and apoptosis...
2024: Open Life Sciences
#30
JOURNAL ARTICLE
Kazutaka Uchida, Leon A Rinkel, Johanna M Ospel, William K Diprose, Mayank Goyal
BACKGROUND: Endovascular treatment (EVT) has become standard of care for patients with anterior circulation large vessel occlusion (LVO) stroke, with indications having recently expanded to late time-window and large ischemic core patients. There is conflicting evidence on whether EVT reduces mortality or only disability. We performed a meta-analysis of randomized controlled trials (RCTs) to assess the effect of EVT on mortality and severe disability. METHODS: We systematically searched PubMed, Web of Science, Scopus, and Embase on November 15, 2023, to identify phase 3 RCTs comparing EVT to best medical treatment (BMT) in patients with anterior circulation LVO stroke in a common effects meta-analysis...
April 2, 2024: Journal of the Neurological Sciences
#31
JOURNAL ARTICLE
Glen J Henson, Ingrid van der Mei, Bruce V Taylor, Paul Blacklow, Suzi B Claflin, Andrew J Palmer, Carol Hurst, Julie A Campbell
PURPOSE: People living with multiple sclerosis (PwMS) in metropolitan Victoria, Australia, experienced a 112-day, COVID-19-related lockdown in mid-2020. Contemporaneously, Australian PwMS elsewhere experienced minimal restrictions, resulting in a natural experiment. This study investigated the relationships between lockdowns, COVID-19-related adversity, and health-related quality of life (HRQoL). It also generated health state utilities (HSU) representative of changes in HRQoL. METHODS: Data were extracted from Australian MS Longitudinal Study surveys, which included the Assessment of Quality of Life-Eight Dimensions (AQoL-8D) instrument and a COVID-19 questionnaire...
April 5, 2024: Quality of Life Research
#32
JOURNAL ARTICLE
Aryane Caroline Silva, Kênia K P Menezes, Aline Alvim Scianni, Patrick R Avelino, Christina Danielli Coelho de Morais Faria
The objective was to investigate, through a systematic review, which independent variables predict health-related quality of life (HRQoL) one year after stroke. Searches were conducted in LILACS, MEDLINE, Scielo, Web of Science, and PEDro. The inclusion criteria were observational longitudinal studies, which included at least one independent variable measured at baseline, as a potential predictor of HRQoL measured 12 months after stroke. The predictors of interest were variables across all domains of the International Classification of Function, Disability and Health...
April 8, 2024: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
#33
JOURNAL ARTICLE
Laura Edwards, Vina Tesorero, Fattaneh Zonouzi, Piera Santullo, Phoebe Owen, Adam L Gordon
BACKGROUND: Frailty correlates with poor clinical outcomes and is not routinely assessed in neurorehabilitation inpatient settings. METHODS: We recruited adults from two neurorehabilitation units. We administered six validated tools for assessing frailty and collected data around length of stay, discharge, readmission and change in rehabilitation outcome measures. RESULTS: Seventy-eight participants aged between 31 and 84 years were recruited with a range of neurological diagnoses...
April 5, 2024: Journal of the Royal College of Physicians of Edinburgh
#34
JOURNAL ARTICLE
Heng-Fen Hu, Yu-Fei Sang, Yan-Qing Xiao
BACKGROUND: Ischemic stroke (IS) is a widely recognized disease characterized by high prevalence, mortality, morbidity, disability, and recurrence rates. It ranks prominently in terms of mortality, constituting 60%-80% of stroke cases. AIM: To explore the impact of comprehensive nursing care on the quality of life and swallowing function in individuals diagnosed with IS. METHODS: This study comprised 172 patients with IS admitted to our hospital between February 2018 to March 2021...
March 16, 2024: World Journal of Clinical Cases
#35
JOURNAL ARTICLE
Daris Francis, Kandaswami Kotteeswaran, Pramod Padinhare Veedu
BACKGROUND AND OBJECTIVES: The widespread presence of diabetic peripheral neuropathy (DN) and its related variables among diagnosed diabetes mellitus (DM) patients in Kerala lacks sufficient evidence. The objective of this study was to evaluate the frequency of DN and its related risk variables among those with DM who were receiving care at a tertiary health institution in Kerala. MATERIALS AND METHODS: This study was conducted in a tertiary health center in Kerala using a cross-sectional design...
March 2024: Curēus
#36
JOURNAL ARTICLE
Haizhu Chen, Ying Zheng, Hua Wu, Naiqing Cai, Guorong Xu, Yi Lin, Jin-Jing Li
BACKGROUND: Autosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized primarily by congenital microcephaly and intellectual disability but without extra-central nervous system malformations. This investigation aimed to elucidate the genetic underpinnings of microcephaly in a patient from a Chinese consanguineous family. METHODS: A comprehensive clinical assessment, including brain magnetic resonance imaging (MRI), electroencephalogram (EEG), and genetic analyses, was conducted to evaluate the patient's condition...
2024: Frontiers in Neurology
#37
REVIEW
Amalia Egle Gentile, Sergio Rinella, Eleonora Desogus, Cristiano Maria Verrelli, Marco Iosa, Vincenzo Perciavalle, Martino Ruggieri, Agata Polizzi
BACKGROUND: Motor Imagery (MI) is a cognitive process consisting in mental simulation of body movements without executing physical actions: its clinical use has been investigated prevalently in adults with neurological disorders. OBJECTIVES: Review of the best-available evidence on the use and efficacy of MI interventions for neurorehabilitation purposes in common and rare childhood neurological disorders. METHODS: systematic literature search conducted according to PRISMA by using the Scopus, PsycArticles, Cinahl, PUBMED, Web of Science (Clarivate), EMBASE, PsychINFO, and COCHRANE databases, with levels of evidence scored by OCEBM and PEDro Scales...
2024: Frontiers in Human Neuroscience
#38
JOURNAL ARTICLE
Cathérine Dekeyser, Matthias Hautekeete, Melissa Cambron, Vincent Van Pesch, Francesco Patti, Jens Kuhle, Samia Khoury, Jeanette Lechner Scott, Oliver Gerlach, Alessandra Lugaresi, Davide Maimone, Andrea Surcinelli, Pierre Grammond, Tomas Kalincik, Mario Habek, Barbara Willekens, Richard Macdonell, Patrice Lalive, Tunde Csepany, Helmut Butzkueven, Cavit Boz, Valentina Tomassini, Matteo Foschi, José Luis Sánchez-Menoyo, Ayse Altintas, Saloua Mrabet, Gerardo Iuliano, Maria Jose Sa, Raed Alroughani, Rana Karabudak, Eduardo Aguera-Morales, Orla Gray, Koen de Gans, Anneke van der Walt, Pamela A McCombe, Norma Deri, Justin Garber, Abdullah Al-Asmi, Olga Skibina, Pierre Duquette, Elisabetta Cartechini, Daniele Spitaleri, Riadh Gouider, Aysun Soysal, Liesbeth Van Hijfte, Mark Slee, Maria Pia Amato, Katherine Buzzard, Guy Laureys
BACKGROUND: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. METHODS: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#39
REVIEW
Serena L Orr
OBJECTIVE: This article reviews the assessment of children and adolescents presenting with headache, provides an overview of primary headache disorders, and reviews evidence-based management of headache in this age group. LATEST DEVELOPMENTS: In the last few years, new epidemiological data have shed light on less common pediatric headache disorders (eg, pediatric trigeminal autonomic cephalalgias) and psychosocial risk factors associated with primary headache disorders in children and adolescents...
April 1, 2024: Continuum: Lifelong Learning in Neurology
#40
JOURNAL ARTICLE
Fatima Salloum, Mohamad Farran, Houssam Shaib, Abdo Jurjus, Roni Sleiman, Mahmoud I Khalil
Obsessive-compulsive disorder (OCD) is a disabling disease characterized by distressing obsessions and repetitive compulsions. The etiology of OCD is poorly known, and mouse modeling allows to clarify the genetic and neurochemical basis of this disorder and to investigate potential treatments. This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice ( n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted...
2024: Behavioural Neurology
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