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Disability neurological assessment

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https://www.readbyqxmd.com/read/29331082/mechanistic-target-of-rapamycin-complex-1-and-2-in-human-temporal-lobe-epilepsy
#1
Delia M Talos, Leah M Jacobs, Sarah Gourmaud, Carlos A Coto, Hongyu Sun, Kuei-Cheng Lim, Timothy H Lucas, Kathryn A Davis, Maria Martinez-Lage, Frances E Jensen
OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) and Complex 2 (mTORC2) activities in the brain, as both pathways may represent unique targets for treatment. METHODS: Surgically resected hippocampal and temporal lobe samples from therapy-resistant TLE patients were analyzed by Western blotting to quantify the expression of established mTORC1 and mTORC2 activity markers and upstream or downstream signaling pathways involving the two complexes...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29316888/the-preventive-effect-of-sensorimotor-and-vibration-exercises-on-the-onset-of-oxaliplatin-or-vinca-alkaloid-induced-peripheral-neuropathies-stop
#2
Fiona Streckmann, Maryam Balke, Helmar C Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T Baumann, Wilhelm Bloch
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29316845/rho-inhibitor-vx-210-in-acute-traumatic-subaxial-cervical-spinal-cord-injury-design-of-the-spinal-cord-injury-rho-inhibition-investigation-spring-clinical-trial
#3
Michael G Fehlings, Kee D Kim, Bizhan Aarabi, Marco Rizzo, Lisa M Bond, Lisa McKerracher, Alexander Vaccaro, David O Okonkwo
Traumatic spinal cord injury (SCI) is associated with a lifetime of disability stemming from loss of motor, sensory, and autonomic functions; these losses, along with increased comorbid sequelae, negatively impact health outcomes and quality of life. Early decompression surgery after SCI can enhance patient outcomes but does not directly facilitate neural repair and regeneration. Currently, there are no FDA-approved pharmacologic therapies to augment motor function and functional recovery in individuals with traumatic SCI...
January 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29310670/the-comparison-of-clinical-outcome-of-fresh-type-ii-odontoid-fracture-treatment-between-anterior-cannulated-screws-fixation-and-posterior-instrumentation-of-c1-2-without-fusion-a-retrospective-cohort-study
#4
Suomao Yuan, Bin Wei, Yonghao Tian, Jun Yan, Wanlong Xu, Lianlei Wang, Xinyu Liu
BACKGROUND: Recently, the excellent outcomes of temporary fixation of C1-2 without fusion in the treatment of odontoid fracture had been reported. It is still unclear if this technique could achieve the equivalent outcomes as the golden standard technique of anterior screw fixation. The objective of this study is to compare the clinical outcome of two treatments of fresh type II odontoid fracture: anterior cannulated screws fixation (ACSF) versus posterior instrumentation of C1-2 without fusion (PIWF)...
January 8, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29306359/the-culturally-adapted-italian-version-of-the-barthel-index-icabi-assessment-of-structural-validity-inter-rater-reliability-and-responsiveness-to-clinically-relevant-improvements-in-patients-admitted-to-inpatient-rehabilitation-centers
#5
S F Castiglia, G Galeoto, A Lauta, A Palumbo, F Tirinelli, F Viselli, Valter Santilli, M L Sacchetti
The Barthel Index (BI) is widely used to determine eligibility criteria for inpatient rehabilitation and to monitor patients' recovery, irrespective of the illnesses that affect them. The culturally adapted Italian version of the Barthel Index (IcaBI) was recently validated. This paper reports the structural validity and inter-rater reliability of the IcaBI and its responsiveness to the results of inpatient rehabilitation. The IcaBI was administered to a cohort of 264 patients hospitalized in two rehabilitation centers in Rome, Italy...
October 2017: Functional Neurology
https://www.readbyqxmd.com/read/29297432/vitamin-d-deficiency-in-patients-with-tuberculous-meningitis-and-its-relationship-with-treatment-outcome
#6
G V Dangeti, S Mailankody, C Neeradi, J Mandal, R Soundravally, N M Joseph, S Kamalanathan, R P Swaminathan, T Kadhiravan
SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β). OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients, its association with treatment outcomes and correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF). DESIGN: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital in southern India...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29291174/clinical-study-to-assess-the-outcome-in-surgically-managed-patients-of-spontaneous-intracerebral-hemorrhage
#7
Yashwanth S Sandeep, M Raja Guru, Ranjan Kumar Jena, Veldurti Ananta Kiran Kumar, Amit Agrawal
Introduction: Spontaneous intracerebral hemorrhage (SICH) subtype of stroke is characterized by bleeding into brain parenchyma which is not accompanied by trauma. Emergency surgical evacuation of large size SICH increases the chances of survival but does not help in functional recovery of the patients. The present study was conducted to assess the outcome of surgical management in patients with SICH. Materials and Methods: All patients who were diagnosed with SICH and underwent surgical evacuation of the hematoma included in the study...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29285552/focal-cortical-thinning-in-patients-with-stable-relapsing-remitting-multiple-sclerosis-cross-sectional-based-novel-estimation-of-gray-matter-kinetics
#8
Lior Orbach, Shay Menascu, Chen Hoffmann, Shmuel Miron, Anat Achiron
PURPOSE: The aim of our study is to identify radiological patterns of cortical gray matter atrophy (CGMA) that correlate with disease duration in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: RRMS patients were randomly selected from the Sheba Multiple Sclerosis (MS) center computerized data registry based on stratification of disease duration up to 10 years. Patients were scanned by 3.0 T (Signa, GE) MRI, using a T1 weighted 3D high resolution, FSPGR, MS protocol...
February 2018: Neuroradiology
https://www.readbyqxmd.com/read/29277330/a-hidden-semi-markov-model-based-approach-for-rehabilitation-exercise-assessment
#9
Marianna Capecci, Maria Gabriella Ceravolo, Francesco Ferracuti, Sabrina Iarlori, Ville Kyrki, Andrea Monteriù, Luca Romeo, Federica Verdini
In this paper, a Hidden Semi-Markov Model (HSMM) based approach is proposed to evaluate and monitor body motion during a rehabilitation training program. The approach extracts clinically relevant motion features from skeleton joint trajectories, acquired by the RGB-D camera, and provides a score for the subject's performance. The approach combines different aspects of rule and template based methods. The features have been defined by clinicians as exercise descriptors and are then assessed by a HSMM, trained upon an exemplar motion sequence...
December 22, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29246614/perceived-embarrassment-and-caregiver-burden-in-essential-tremor-caregivers
#10
Sarah Kellner, Sarah Morgan, Jesus Gutierrez, Kathleen Collins, Brittany Rohl, Fanny Migliore, Stephanie Cosentino, Edward D Huey, Elan D Louis, Joan K Monin
Essential tremor (ET) is a progressive neurological disease associated with functional disability, diminished quality of life and, in some individuals, poorer balance, cognitive impairment, depression and sleep dysregulation. Individuals with ET may rely on family members and friends to act as informal caregivers to assist with daily activities and provide emotional support. There is a high prevalence of embarrassment among individuals with ET, which may be a result of the outwardly visible nature of tremor...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29245281/spontaneous-spinal-epidural-hematoma-mimicking-transient-ischemic-attack-a-case-report
#11
Chuqiao Li, Rui He, Xiaoqiang Li, Yulan Zhong, Li Ling, Fangming Li
RATIONALE: Spontaneous spinal epidural hematoma (SSEH) is a rare but highly disabling neurological emergency. The initial presentations are variable. Most patients of SSEH present with paraplegia or tetraplegia clinically, but recurrent hemiparesis with complete spontaneous recovery, mimicking transient ischemic attack (TIA), is a very rare initial presentation of SSEH. PATIENT CONCERNS: A 71-year-old female presented to the emergency department with 2 episodes of transient right hemiparesis in 5 hours...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245217/efficacy-and-safety-of-mobi-c-cervical-artificial-disc-versus-anterior-discectomy-and-fusion-in-patients-with-symptomatic-degenerative-disc-disease-a-meta-analysis
#12
Hui Lu, Lihua Peng
BACKGROUND: Total disc replacement (TDR) using Mobi-C cervical artificial disc might be promising to treat symptomatic degenerative disc disease. However, the results remained controversial. We conducted a systematic review and meta-analysis to compare the efficacy and safety of Mobi-C cervical artificial disc and anterior cervical discectomy and fusion (ACDF) in patients with symptomatic degenerative disc disease. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241812/exploiting-the-therapeutic-potential-of-ready-to-use-drugs-repurposing-antibiotics-against-amyloid-aggregation-in-neurodegenerative-diseases
#13
REVIEW
Sergio B Socias, Florencia Gonzalez-Lizarraga, Cesar L Avila, Cecilia Vera, Leonardo Acuña, Julia E Sepulveda-Diaz, Elaine Del-Bel, Rita Raisman-Vozari, Rosana N Chehin
Neurodegenerative diseases are chronic and progressive disorders that affect specific regions of the brain, causing gradual disability and suffering that results in a complete inability of patients to perform daily functions. Amyloid aggregation of specific proteins is the most common biological event that is responsible for neuronal death and neurodegeneration in various neurodegenerative diseases. Therapeutic agents capable of interfering with the abnormal aggregation are required, but traditional drug discovery has fallen short...
December 11, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29234493/what-are-the-risks-of-manual-treatment-of-the-spine-a-scoping-review-for-clinicians
#14
REVIEW
Gabrielle Swait, Rob Finch
Background: Communicating to patients the risks of manual treatment to the spine is an important, but challenging element of informed consent. This scoping review aimed to characterise and summarise the available literature on risks and to describe implications for clinical practice and research. Method: A methodological framework for scoping reviews was followed. Systematic searches were conducted during June 2017. The quantity, nature and sources of literature were described...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29230406/intraoperative-myelography-in-transpsoas-lateral-lumbar-interbody-fusion-for-degenerative-lumbar-spinal-stenosis-a-preliminary-prospective-study
#15
Yang Yang, Liangming Zhang, Jianwen Dong, Zihao Chen, Peigen Xie, Ruiqiang Chen, Lei He, Feng Feng, Limin Rong, Bin Liu
Aim: To investigate the feasibility and effectiveness of intraoperative myelography in determining adequacy of indirect spinal canal decompression during transpsoas lateral lumbar interbody fusion (LLIF). Methods: Seven patients diagnosed with degenerative lumbar spinal stenosis (DLSS) were prospectively included to this study. All patients underwent LLIF and subsequently received intraoperative myelography to determine the effect of indirect spinal canal decompression, which was visualized in both anterior-posterior and lateral images...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29223621/does-observation-of-a-disabled-child-s-action-moderate-action-execution-implication-for-the-use-of-action-observation-therapy-for-patient-rehabilitation
#16
Marie Alsamour, Maxime Gilliaux, Anne Renders, Thierry Lejeune, Gaëtan Stoquart, Martin Gareth Edwards
BACKGROUND: Research investigating action observation-execution priming has mainly manipulated congruent versus incongruent action, and aspects of action expertise/capability. More specifically, the literature suggests enhanced performance priming following action observation by actors closely matched to participant expertise. The aim of the present study was to extend the understanding of action expertise effects by investigating action priming in healthy participants after observing a mild hemiparetic child actor versus a neurologically healthy child actor...
November 15, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29220866/neural-correlates-of-fatigue-in-multiple-sclerosis-a-combined-neurophysiological-and-neuroimaging-approach-r1
#17
M Russo, A Calamuneri, A Cacciola, L Bonanno, A Naro, V Dattola, E Sessa, M Buccafusca, D Milardi, P Bramanti, R S Calabrò, A Quartarone
The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural white matter damage may subtend the cortico-subcortical functional disconnection described in patients with MS and fatigue...
September 30, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29216914/rasch-analysis-of-the-participation-scale-p-scale-usefulness-of-the-p-scale-to-a-rehabilitation-services-network
#18
Mariana Angélica Peixoto Souza, Wendy Jane Coster, Marisa Cotta Mancini, Fabiana Caetano Martins Silva Dutra, Jessica Kramer, Rosana Ferreira Sampaio
BACKGROUND: A person's participation is acknowledged as an important outcome of the rehabilitation process. The Participation Scale (P-Scale) is an instrument that was designed to assess the participation of individuals with a health condition or disability. The scale was developed in an effort to better describe the participation of people living in middle-income and low-income countries. The aim of this study was to use Rasch analysis to examine whether the Participation Scale is suitable to assess the perceived ability to take part in participation situations by patients with diverse levels of function...
December 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29214702/skin-injuries-and-joint-contractures-of-the-upper-extremities-in-rett-syndrome
#19
D Hirano, T Taniguchi
OBJECTIVES: The purpose of this study was to investigate the incidence and type of skin injuries and joint contractures of the upper extremities in individuals with Rett syndrome. METHODS: In 2016, a questionnaire regarding skin injuries and joint contractures was sent to 1016 directors of schools for special needs education and 204 directors of departments of rehabilitation [consisting of 130 facilities for persons with severe motor and intellectual disabilities (SMID), 73 wards for patients with SMID, and the National Hospital Organisation and National Centre Hospital, National Centre of Neurology and Psychiatry] in Japan...
January 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29212862/ataxia-with-oculomotor-apraxia-type-2-an-evolving-axonal-neuropathy
#20
Tahira N Choudry, David Hilton-Jones, Graham Lennox, Henry Houlden
A 23-year-old woman had presented initially to a podiatrist complaining of poorly fitting shoes during her adolescence. After extensive neurological review, she was diagnosed with ataxia with oculomotor apraxia type 2. This is a progressive autosomal recessive ataxia associated with cerebellar atrophy, peripheral neuropathy and an elevated serum α-fetoprotein. Within Europe, it is the most frequent autosomal recessive ataxia after Friedreich's ataxia and is due to mutations in the senataxin (SETX) gene. The age of onset is approximately 15 years...
December 6, 2017: Practical Neurology
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