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https://www.readbyqxmd.com/read/27917358/rigorous-solution-for-1-d-consolidation-of-a-clay-layer-under-haversine-cyclic-loading-with-rest-period
#1
Nina Müthing, Sabah S Razouki, Maria Datcheva, Tom Schanz
Presented in this paper is a rigorous solution of the conventional Terzaghi one-dimensional consolidation under haversine cyclic loading with any rest period. The clay deposit is either permeable at both top and bottom or permeable at the top and impermeable at the bottom. This exact analytical solution was achieved using Fourier harmonic analysis for the periodic function representing the rate of imposition of excess pore water pressure. The double Fourier series in the rigorous solution was found to be rapidly convergent...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27911727/role-of-the-bone-morphogenic-protein-pathway-in-developmental-haemopoiesis-and-leukaemogenesis
#2
REVIEW
Parto Toofan, Helen Wheadon
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage. Chronic myeloid leukaemia (CML) arises from a genetic alteration in a normal haemopoietic stem cell (HSC) giving rise to a leukaemic stem cell (LSC) within the bone marrow (BM) 'niche'. CML is characterised by the presence of the oncogenic tyrosine kinase fusion protein breakpoint cluster region-abelson murine leukaemia viral oncogene homolog 1 (BCR-ABL), which is responsible for driving the disease through activation of downstream signal transduction pathways...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27907833/development-of-a-scale-to-evaluate-young-children-s-responses-to-uncertainty-and-low-environmental-structure
#3
Amanda L Sanchez, Danielle Cornacchio, Tommy Chou, Ovsanna Leyfer, Stefany Coxe, Donna Pincus, Jonathan S Comer
Intolerance of Uncertainty (IU), defined as the dispositional interpretation of uncertain or ambiguous events as stressful and problematic, has been linked to excessive worry and other anxiety-related problems in adults and youth. IU has been conceptualized as a vulnerability factor for excessive worry and anxiety, but the historical absence of a supported measure of IU in young children has hampered longitudinal research needed to evaluate temporal relationships between IU and anxiety and the differential developmental pathways of IU leading to different anxiety disorders and depression...
November 21, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27891107/internet-communication-disorder-it-s-a-matter-of-social-aspects-coping-and-internet-use-expectancies
#4
Elisa Wegmann, Matthias Brand
Online communication applications such as Facebook, WhatsApp, and Twitter are some of the most frequently used Internet applications. There is a growing amount of individuals suffering diminished control over their use of online communication applications which leads to diverse negative consequences in offline life. This could be referred to as Internet-communication disorder (ICD). The current study investigates the role of individual characteristics (e.g., psychopathological symptoms, feelings of loneliness) and specific cognitions...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27878136/phenotypic-convergence-of-menkes-and-wilson-disease
#5
Boglarka Bansagi, David Lewis-Smith, Endre Pal, Jennifer Duff, Helen Griffin, Angela Pyle, Juliane S Müller, Gabor Rudas, Zsuzsanna Aranyi, Hanns Lochmüller, Patrick F Chinnery, Rita Horvath
Menkes disease is an X-linked multisystem disorder with epilepsy, kinky hair, and neurodegeneration caused by mutations in the copper transporter ATP7A. Other ATP7A mutations have been linked to juvenile occipital horn syndrome and adult-onset hereditary motor neuropathy.(1,2) About 5%-10% of the patients present with "atypical Menkes disease" characterized by longer survival, cerebellar ataxia, and developmental delay.(2) The intracellular copper transport is regulated by 2 P type ATPase copper transporters ATP7A and ATP7B...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27871306/akirin2-is-essential-for-the-formation-of-the-cerebral-cortex
#6
Peter J Bosch, Leah C Fuller, Carolyn M Sleeth, Joshua A Weiner
BACKGROUND: The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cells, disruption of cell cycle timing, excessive apoptosis, and/or incorrect neuronal migration signals can have devastating effects, resulting in a number of neurodevelopmental disorders involving microcephaly and/or lissencephaly. Though genes encoding many key players in cortical development have been identified, our understanding remains incomplete...
November 21, 2016: Neural Development
https://www.readbyqxmd.com/read/27834738/contribution-of-adaptive-thermogenesis-to-the-hypothalamic-regulation-of-energy-balance
#7
REVIEW
Ricardo Lage, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, Miguel López
Obesity and its related disorders are among the most pervasive diseases in contemporary societies, and there is an urgent need for new therapies and preventive approaches. Given (i) our poor social capacity to correct unhealthy habits, and (ii) our evolutionarily genetic predisposition to store excess energy as fat, the current environment of caloric surplus makes the treatment of obesity extremely difficult. During the last few decades, an increasing number of methodological approaches have increased our knowledge of the neuroanatomical basis of the control of energy balance...
November 15, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27829393/advice-given-by-community-members-to-pregnant-women-a-mixed-methods-study
#8
Bianca A Verma, Lauren P Nichols, Melissa A Plegue, Michelle H Moniz, Manisha Rai, Tammy Chang
BACKGROUND: Smoking and excess weight gain during pregnancy have been shown to have serious health consequences for both mothers and their infants. Advice from friends and family on these topics influences pregnant women's behaviors. The purpose of our study was to compare the advice that community members give pregnant women about smoking versus the advice they give about pregnancy weight gain. METHODS: A survey was sent via text messaging to adults in a diverse, low-income primary care clinic in 2015...
November 9, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27811276/ocean-mixing-and-ice-sheet-control-of-seawater-234u-238u-during-the-last-deglaciation
#9
Tianyu Chen, Laura F Robinson, Matthew P Beasley, Louis M Claxton, Morten B Andersen, Lauren J Gregoire, Jemma Wadham, Daniel J Fornari, Karen S Harpp
Seawater (234)U/(238)U provides global-scale information about continental weathering and is vital for marine uranium-series geochronology. Existing evidence supports an increase in (234)U/(238)U since the last glacial period, but the timing and amplitude of its variability has been poorly constrained. Here we report two seawater (234)U/(238)U records based on well-preserved deep-sea corals from the low-latitude Atlantic and Pacific Oceans. The Atlantic (234)U/(238)U started to increase before major sea-level rise and overshot the modern value by 3 per mil during the early deglaciation...
November 4, 2016: Science
https://www.readbyqxmd.com/read/27799577/high-ac-a-ratio-esotropia-do-we-really-need-to-be-using-bifocals
#10
Scott E Olitsky
INTRODUCTION AND PURPOSE: Most strabismus specialists use bifocals for patients with convergence excess esotropia whose distance deviation is small. While this is a popular treatment modality, there is actually no good data to indicate that this should be considered a standard of care. PATIENTS AND METHODS: In patients for whom the distance deviation is small enough to allow for the development of binocular vision, my preference is to simply observe these patients...
January 2016: American Orthoptic Journal
https://www.readbyqxmd.com/read/27787894/docosahexaenoic-acid-up-regulates-both-pi3k-akt-dependent-fabp7-ppar%C3%AE-interaction-and-mkp3-that-enhance-gfap-in-developing-rat-brain-astrocytes
#11
Sachin Tripathi, Rajesh Kushwaha, Juhi Mishra, Manoj Kumar Gupta, Harish Kumar, Somali Sanyal, Dhirendra Singh, Sabyasachi Sanyal, Amogh Anant Sahasrabuddhe, Mohan Kamthan, Mohana Krishna Reddy Mudiam, Sanghamitra Bandyopadhyay
The astrocyte marker, glial fibrillary acidic protein (GFAP), has essential functions in the brain, but may trigger astroglial scarring when expressed in excess. Docosahexaenoic acid (DHA) is an n-3 fatty acid that is protective during brain development. However, the effect of DHA on GFAP levels of developing brain remains unexplored. Here we detected that treating developing rats with DHA-enriched fish-oil caused dose-dependent GFAP augmentation. We investigated the mechanism promoting GFAP, hypothesizing the participation of fatty acid-binding protein-7 (FABP7), known to bind DHA...
October 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27734410/regulation-of-interleukin-10-expression
#12
Sascha Rutz, Wenjun Ouyang
Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota. IL-10 also functions to prevent excessive inflammation during the course of infection. IL-10 can be produced in response to pro-inflammatory signals by virtually all immune cells, including T cells, B cells, macrophages, and dendritic cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27662318/mitochondrial-dysfunction-and-synaptic-transmission-failure-in-alzheimer-s-disease
#13
Lan Guo, Jing Tian, Heng Du
Alzheimer's disease (AD) is a chronic neurodegenerative disorder, in which multiple risk factors converge. Despite the complexity of the etiology of the disease, synaptic failure is the pathological basis of cognitive impairment, the cardinal sign of AD. Decreased synaptic density, compromised synaptic transmission, and defected synaptic plasticity are hallmark synaptic pathologies accompanying AD. However, the mechanisms by which synapses are injured in AD-related conditions have not been fully elucidated yet...
September 20, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27647120/comparison-between-medial-rectus-pulley-fixation-and-augmented-recession-in-children-with-convergence-excess-and-variable-angle-infantile-esotropia
#14
Heba M Fouad, Mohamad A Abdelhakim, Ahmed Awadein, Hala Elhilali
PURPOSE: To compare the outcomes of medial rectus (MR) muscle pulley fixation and augmented recession in children with convergence excess esotropia and variable-angle infantile esotropia. METHODS: This was a prospective randomized interventional study in which children with convergence excess esotropia or variable-angle infantile esotropia were randomly allocated to either augmented MR muscle recession (augmented group) or MR muscle pulley posterior fixation (pulley group)...
September 16, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27634570/septin7-regulates-inner-ear-formation-at-an-early-developmental-stage
#15
Hiroko Torii, Atsuhiro Yoshida, Tatsuya Katsuno, Takayuki Nakagawa, Juichi Ito, Koichi Omori, Makoto Kinoshita, Norio Yamamoto
Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiological functions of many mammalian cell types including the regulation of microtubule stability, vesicle trafficking, cortical rigidity, planar cell polarity, and apoptosis. The inner ear, which perceives auditory and equilibrium sensation with highly differentiated hair cells, has a complicated gross morphology...
September 12, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27619163/cytokine-amplification-and-macrophage-effector-functions-in-aortic-inflammation-and-abdominal-aortic-aneurysm-formation
#16
COMMENT
Talha Ijaz, Ronald G Tilton, Allan R Brasier
On April 29, 2015, Son and colleagues published an article entitled "Granulocyte macrophage colony-stimulating factor (GM-CSF) is required for aortic dissection/intramural haematoma" in Nature Communications. The authors observed that the heterozygous Kruppel-like transcription factor 6 (KLF6) deficiency or absence of myeloid-specific KLF6 led to upregulation of macrophage GM-CSF expression, promoted the development of aortic hematoma/dissection, and stimulated abdominal aortic aneurysm (AAA) formation when the vessel wall was subjected to an inflammatory stimulus...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27591222/vagal-stimulation-targets-select-populations-of-intrinsic-cardiac-neurons-to-control-neurally-induced-atrial-fibrillation
#17
Siamak Salavatian, Eric Beaumont, Jean-Philippe Longpré, J Andrew Armour, Alain Vinet, Vincent Jacquemet, Kalyanam Shivkumar, Jeffrey L Ardell
Mediastinal nerve stimulation (MNS) reproducibly evokes atrial fibrillation (AF) by excessive and heterogeneous activation of intrinsic cardiac (IC) neurons. This study evaluated whether preemptive vagus nerve stimulation (VNS) impacts MNS-induced evoked changes in IC neural network activity to thereby alter susceptibility to AF. IC neuronal activity in the right atrial ganglionated plexus was directly recorded in anesthetized canines (n = 8) using a linear microelectrode array concomitant with right atrial electrical activity in response to: 1) epicardial touch or great vessel occlusion vs...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27588575/development-of-a-general-baseline-toxicity-qsar-model-for-the-fish-embryo-acute-toxicity-test
#18
Nils Klüver, Carolina Vogs, Rolf Altenburger, Beate I Escher, Stefan Scholz
Fish embryos have become a popular model in ecotoxicology and toxicology. The fish embryo acute toxicity test (FET) with the zebrafish embryo was recently adopted by the OECD as technical guideline TG 236 and a large database of concentrations causing 50% lethality (LC50) is available in the literature. Quantitative Structure-Activity Relationships (QSARs) of baseline toxicity (also called narcosis) are helpful to estimate the minimum toxicity of chemicals to be tested and to identify excess toxicity in existing data sets...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27583033/convergent-evolution-of-trna-gene-targeting-preferences-in-compact-genomes
#19
Thomas Spaller, Eva Kling, Gernot Glöckner, Falk Hillmann, Thomas Winckler
BACKGROUND: In gene-dense genomes, mobile elements are confronted with highly selective pressure to amplify without causing excessive damage to the host. The targeting of tRNA genes as potentially safe integration sites has been developed by retrotransposons in various organisms such as the social amoeba Dictyostelium discoideum and the yeast Saccharomyces cerevisiae. In D. discoideum, tRNA gene-targeting retrotransposons have expanded to approximately 3 % of the genome. Recently obtained genome sequences of species representing the evolutionary history of social amoebae enabled us to determine whether the targeting of tRNA genes is a generally successful strategy for mobile elements to colonize compact genomes...
2016: Mobile DNA
https://www.readbyqxmd.com/read/27537007/examining-the-construct-validity-of-affective-judgments-of-physical-activity-measures
#20
Michael Chmielewski, Margarita Sala, Rui Tang, Austin Baldwin
Affective judgments of physical activity have emerged as important predictors of physical activity and interventions targeting affective judgments are a promising approach to improving regular physical activity. Currently, measures assessing a variety of potentially distinct constructs are treated as interchangeable assessments of affective judgments of physical activity. Moreover, little is known about the construct validity of the purported measures of this construct. We review several components of construct validity; highlighting their importance for health psychology research...
September 2016: Psychological Assessment
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