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https://www.readbyqxmd.com/read/28713311/validation-of-spanish-language-evaluation-instruments-for-body-dysmorphic-disorder-and-the-dysmorphic-concern-construct
#1
Cristina Senín-Calderón, María Valdés-Díaz, Ma M Benítez-Hernández, Ma C Núñez-Gaitán, Salvador Perona-Garcelán, Rafael Martínez-Cervantes, Juan F Rodríguez-Testal
Dysmorphic concern (DC) refers to excessive preoccupation with a slight or imagined defect in physical appearance with social avoidance and behavior directed at controlling the defect in appearance. This study attempted to adapt the factor structure of two instruments that cover the DC construct, the Dysmorphic Concern Questionnaire (DCQ) and the Body Dysmorphic Disorder Examination Self-Report (BDDE-SR), to Spanish and establish their psychometric properties. A total of 920 subjects (62.7% women, Mage = 32...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28682229/-epigenetic-mechanisms-and-alcohol-use-disorders-a-potential-therapeutic-target
#2
Rémi Legastelois, Jérôme Jeanblanc, Catherine Vilpoux, Erika Bourguet, Mickael Naassila
Alcohol use disorder is a devastating illness with a profound health impact, and its development is dependent on both genetic and environmental factors. This disease occurs over time and requires changes in brain gene expression. There is converging evidence suggesting that the epigenetic processes may play a role in the alcohol-induced gene regulations and behavior such as the intervention of DNA methylation and histone acetylation. Histone acetylation, like histone methylation, is a highly dynamic process regulated by two classes of enzymes: histone acetyltransferases and histone deacetylases (HDACs)...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/28674175/enhanced-excitatory-connectivity-and-disturbed-sound-processing-in-the-auditory-brainstem-of-fragile-x-mice
#3
Elisabet Garcia-Pino, Nikodemus Gessele, Ursula Koch
Hypersensitivity to sounds is one of the prevalent symptoms in individuals with Fragile X syndrome (FXS). It manifests behaviorally early during development and is often used as a landmark for treatment efficacy. However, the physiological mechanisms and circuit-level alterations underlying this aberrant behavior remain poorly understood. Using the mouse model of FXS (Fmr1 KO) we demonstrate that functional maturation of auditory brainstem synapses is impaired in FXS. Fmr1 KO mice showed a greatly enhanced excitatory synaptic input strength in neurons of the lateral superior olive (LSO), a prominent auditory brainstem nucleus, which integrates ipsilateral excitation and contralateral inhibition to compute interaural level differences (ILDs)...
July 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28673574/ldl-c-levels-in-older-people-cholesterol-homeostasis-and-the-free-radical-theory-of-ageing-converge
#4
Mark T Mc Auley, Kathleen M Mooney
The cardiovascular disease (CVD) risk factor, low density lipoprotein cholesterol (LDL-C) increases with age, up until the midpoint of life in males and females. However, LDL-C can decrease with age in older men and women. Intriguingly, a recent systematic review also revealed an inverse association between LDL-C levels and cardiovascular mortality in older people; low levels of LDL-C were associated with reduced risk of mortality. Such findings are puzzling and require a biological explanation. In this paper a hypothesis is proposed to explain these observations...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28652690/combined-resection-recession-versus-combined-recession-retroequatorial-myopexy-of-medial-rectus-muscles-for-treatment-of-near-distance-disparity-esotropia
#5
Manar A Ghali
PURPOSE: To compare and evaluate the efficacy of two different surgical techniques for the treatment of near-distance disparity esotropia; combined resection-recession and recession-retroequatorial myopexy of medial rectus muscles. PATIENTS AND METHODS: This prospective study included 28 patients diagnosed with convergence excess esotropia who had worn their full cycloplegic refraction and/or bifocal glasses for at least 6 months and still had near-distance disparity esotropia...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28641777/role-of-parl-pink1-parkin-pathway-in-adipocyte-differentiation
#6
Ming-Yuh Shiau, Pin-Shen Lee, Ying-Jyun Huang, Ching-Ping Yang, Chiao-Wan Hsiao, Kai-Yun Chang, Huan-Wen Chen, Yih-Hsin Chang
OBJECTIVE: Adipogenesis determines the number of adipocytes which is increased when individuals become obese. Mitochondria undergo remarkable morphological and functional changes during adipogenesis. PTEN-induced kinase 1 (PINK1) is pivotal to maintain mitochondrial homeostasis in neural cells. The present study aimed at investigating effects of PINK1 on adipogenesis and energy metabolism. METHODS: Expression of presenilin associated rhomboid-like protein (PARL), PINK1 and Parkin, as well as the interaction among these proteins was temporally examined during adipogenesis...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28634598/previously-unrecognized-behavioral-phenotype-in-gaucher-disease-type-3
#7
Magy Abdelwahab, Michael Potegal, Elsa G Shapiro, Igor Nestrasil
OBJECTIVE: To provide a comprehensive description of abnormal behaviors in patients with Gaucher disease type 3 (GD3) and relate these behaviors to demographic, neurodevelopmental, and neurologic characteristics. METHODS: Thirty-four Egyptian patients with GD3 (mean age of 7.9 years) were enrolled in the study. They were selected based on parent report and/or physician observation of one or more abnormal behaviors documented in 2 settings and by 2 different individuals and/or by video recording...
June 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28590754/multilevel-approaches-within-the-local-pair-natural-orbital-framework
#8
Manuel Sparta, Marius Retegan, Peter Pinski, Christoph Riplinger, Ute Becker, Frank Neese
The linear-scaling local coupled cluster method DLPNO-CCSD(T) allows calculations on systems containing hundreds of atoms to be performed while reproducing canonical CCSD(T) energies typically with chemical accuracy (<1 kcal/mol). The accuracy of the method is determined by two main truncation thresholds that control the number of electron pairs included in the CCSD iterations and the size of the pair natural orbital virtual space for each electron pair, respectively. While the results of DLPNO-CCSD(T) calculations converge smoothly toward their canonical counterparts as the thresholds are tightened, the improved accuracy is accompanied by a fairly steep increase of the computational cost...
June 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28567428/acl-roof-impingement-revisited-does-the-independent-femoral-drilling-technique-avoid-roof-impingement-with-anteriorly-placed-tibial-tunnels
#9
John A Tanksley, Brian C Werner, Evan J Conte, David P Lustenberger, M Tyrrell Burrus, Stephen F Brockmeier, F Winston Gwathmey, Mark D Miller
BACKGROUND: Anatomic femoral tunnel placement for single-bundle anterior cruciate ligament (ACL) reconstruction is now well accepted. The ideal location for the tibial tunnel has not been studied extensively, although some biomechanical and clinical studies suggest that placement of the tibial tunnel in the anterior part of the ACL tibial attachment site may be desirable. However, the concern for intercondylar roof impingement has tempered enthusiasm for anterior tibial tunnel placement...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28556256/two-step-inversion-with-a-logarithmic-transformation-for-microwave-breast-imaging
#10
Paul M Meaney, Shireen D Geimer, Keith D Paulsen
PURPOSE: The authors have developed a new two-step microwave tomographic image reconstruction process specifically designed to incorporate logarithmic transformed microwave imaging algorithms as a means of significantly improving spatial resolution and target property recovery. Log transform eliminates the need for a priori information, but spatial filtering often integrated as part of the regularization required to stabilize image recovery, generally smooths image features and reduces object definition...
May 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/28533685/factor-structure-reliability-and-validity-of-the-japanese-version-of-the-hoarding-rating-scale-self-report-hrs-sr-j
#11
Aki Tsuchiyagaito, Satoshi Horiuchi, Toko Igarashi, Yoshiya Kawanori, Yoshiyuki Hirano, Hirooki Yabe, Akiko Nakagawa
BACKGROUND: The Hoarding Rating Scale-Self-Report (HRS-SR) is a five-item scale that assesses the symptoms of hoarding. These symptoms include excessive acquisition, difficulty in discarding, and excessive clutter that causes distress. We conducted three studies to examine the factor structure, reliability, and validity of the Japanese version of the HRS-SR (HRS-SR-J). METHODS: Study 1 examined its reliability; 193 college students and 320 adolescents and adults completed the HRS-SR-J and, of the college students, 32 took it again 2 weeks later...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28516374/role-of-lps-elicited-signaling-in-triggering-gastric-mucosal-inflammatory-responses-to-h-pylori-modulatory-effect-of-ghrelin
#12
REVIEW
B L Slomiany, A Slomiany
Infection with Helicobacter pylori is a primary culprit in the etiology of gastric disease, and its cell-wall lipopolysaccharide (LPS) is recognized as a potent endotoxin responsible for triggering a pattern of the mucosal inflammatory responses. The engagement by the LPS of gastric mucosal Toll-like receptor 4 (TLR4) leads to initiation of signal transduction events characterized by the activation of mitogen-activated protein kinase (MAPK) cascade, induction of phosphoinositide-specific phospholipase C (PLC)/protein kinase C (PKC)/phosphatidylinositol 3-kinase (PI3K) pathway, and up-regulation in Src/Akt...
May 17, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28506723/a-chronicle-of-surgical-thinking-and-doing-for-exotropia-innovations-and-rediscoveries
#13
Edward L Raab
PURPOSE: To review the evolution of theories and practices concerning surgery for exotropia over the last approximately 200 years. METHODS: Major ophthalmology texts and relevant references were reviewed to discover experience and thinking concerning the causes of comitant intermittent and constant exotropia and corrective surgical approaches. RESULTS: The concept that excessive divergence is the cause of comitant exotropia has given way to one recognizing that this disorder is a position of rest modified by convergence...
May 12, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28436894/online-learning-algorithms-can-converge-comparably-fast-as-batch-learning
#14
Junhong Lin, Ding-Xuan Zhou
Online learning algorithms in a reproducing kernel Hilbert space associated with convex loss functions are studied. We show that in terms of the expected excess generalization error, they can converge comparably fast as corresponding kernel-based batch learning algorithms. Under mild conditions on loss functions and approximation errors, fast learning rates and finite sample upper bounds are established using polynomially decreasing step-size sequences. For some commonly used loss functions for classification, such as the logistic and the p-norm hinge loss functions with p ∈ [1,2], the learning rates are the same as those for Tikhonov regularization and can be of order O(T-(1/2) log T), which are nearly optimal up to a logarithmic factor...
April 24, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28434937/defining-a-research-agenda-to-address-the%C3%A2-converging-epidemics-of-tuberculosis-and-diabetes-part-2-underlying-biologic-mechanisms
#15
REVIEW
Katharina Ronacher, Reinout van Crevel, Julia A Critchley, Andrew A Bremer, Larry S Schlesinger, Anil Kapur, Randall Basaraba, Hardy Kornfeld, Blanca I Restrepo
There is growing interest in the re-emerging interaction between type 2 diabetes (DM) and TB, but the underlying biologic mechanisms are poorly understood despite their possible implications in clinical management. Experts in epidemiologic, public health, basic science, and clinical studies recently convened and identified research priorities for elucidating the underlying mechanisms for the co-occurrence of TB and DM. We identified gaps in current knowledge of altered immunity in patients with DM during TB, where most studies suggest an underperforming innate immunity, but exaggerated adaptive immunity to Mycobacterium tuberculosis...
July 2017: Chest
https://www.readbyqxmd.com/read/28408285/from-epigenetic-landscape-to-phenotypic-fitness-landscape-evolutionary-effect-of-pathogens-on-host-traits
#16
Mark Jayson V Cortez, Jomar F Rabajante, Jerrold M Tubay, Ariel L Babierra
The epigenetic landscape illustrates how cells differentiate through the control of gene regulatory networks. Numerous studies have investigated epigenetic gene regulation but there are limited studies on how the epigenetic landscape and the presence of pathogens influence the evolution of host traits. Here, we formulate a multistable decision-switch model involving several phenotypes with the antagonistic influence of parasitism. As expected, pathogens can drive dominant (common) phenotypes to become inferior through negative frequency-dependent selection...
April 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28401699/sling-scoop-squirter-anatomical-features-facilitating-prey-transport-processing-and-swallowing-in-rorqual-whales-mammalia-balaenopteridae
#17
Alexander J Werth, Haruka Ito
Much is known about lunge feeding in balaenopterid whales, but many key aspects of structure, function, and behavior have not yet been explained in detail, especially with regard to concentrating, positioning, and swallowing large aggregations of prey. We describe a novel system of three integrated structural components, all of which are involved in sequential feeding activities (intraoral transport, filtration, and swallowing of prey) that follow lunge-feeding engulfment of prey-laden water in rorquals: 1) a hammock-like muscular sling comprising extrinsic lingual musculature along the midline of the ventral pouch; 2) the flattened scoop-like arrangement of caudal-most baleen plates converging in the oropharynx adjacent to the esophageal opening; and 3) a flow-diverting flange at the posterior dorsum of the lip, by a flow channel at the angle of the mouth...
April 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28400779/making-plants-break-a-sweat-the-structure-function-and-evolution-of-plant-salt-glands
#18
REVIEW
Maheshi Dassanayake, John C Larkin
Salt stress is a complex trait that poses a grand challenge in developing new crops better adapted to saline environments. Some plants, called recretohalophytes, that have naturally evolved to secrete excess salts through salt glands, offer an underexplored genetic resource for examining how plant development, anatomy, and physiology integrate to prevent excess salt from building up to toxic levels in plant tissue. In this review we examine the structure and evolution of salt glands, salt gland-specific gene expression, and the possibility that all salt glands have originated via evolutionary modifications of trichomes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28374658/the-inner-world-of-overactive-monitoring-neural-markers-of-interoception-in-obsessive-compulsive-disorder
#19
A Yoris, A M García, L Traiber, H Santamaría-García, M Martorell, F Alifano, R Kichic, J S Moser, M Cetkovich, F Manes, A Ibáñez, L Sedeño
BACKGROUND: Obsessive-compulsive disorder (OCD) patients typically overmonitor their own behavior, as shown by symptoms of excessive doubt and checking. Although this is well established for the patients' relationship with external stimuli in the environment, no study has explored their monitoring of internal body signals, a process known to be affected in anxiety-related syndromes. Here, we explored this issue through a cardiac interoception task that measures sensing of heartbeats. Our aim was to explore key behavioral and electrophysiological aspects of internal-cue monitoring in OCD, while examining their potential distinctiveness in this condition...
April 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28366343/the-french-sleep-disturbance-scale-for-children
#20
Benjamin Putois, Wendy Leslie, Marie Paule Gustin, Marie-Josèphe Challamel, Aude Raoux, Anne Guignard-Perret, Diane Weick, Jean-Baptiste Sauzeau, Vania Herbillon, Filio Zourou, Karen Spruyt, Patricia Franco
OBJECTIVE: The psychometric properties of the Sleep Disturbance Scale for Children (SDSC) have been shown to be accurate, even when translated into several languages. The aim of the present study was to translate, adapt, and validate the SDSC for a French-speaking population. METHODS: After forward- and back-translation, the tool was further translated and adapted into the French language. It was then pretested in terms of clarity on 33 French-speaking parents. Pretesting demonstrated that the questionnaire was well understood, indicating good clarity...
April 2017: Sleep Medicine
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